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<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIT6</accession>
    <name>A0AAV6TIT6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003527">
        <property type="protein sequence ID" value="KAG8171807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIT6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13749" checksum="D3D5E9A50ABF4750" modified="2024-11-27" version="1" fragment="single">MVRPDSKKGIVEYLSNKFDKRHYLDATYRMMDKLHEQTPKIKELFFKNTLSLIPNKEISLVFFDVTTLYFESVEIDELRAFGYSKDHRFNTTQLVLALATNEDGLPLGYELFSGNTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJL1</accession>
    <name>A0AAV6TJL1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003745">
        <property type="protein sequence ID" value="KAG8171635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJL1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="322" mass="36467" checksum="CDD7BBF6921B233C" modified="2024-11-27" version="1">MANLKDKPTDLKKTVEYNRHNPPNNKSDFCIPLDKLITKFSENKNNHLCRYLTEVCENLRDFMSSYNKYQLSLGTQNTLVGEFFSPPILKLYSECAKLNNNLNESRRLSERSNSSIVTDQDPQDLRGELDVAHSKISTLEKKLEDMTIAMQDHLKNSVQLQVAKDSLETSYTTRSGELQDAAKAAAKSIETVYNEKCAMLEQLKDERISQAKKDDQHRVANLKIMKETLENITSNFYSNESEHIDRILKGITESRDKQDSQIQNALDKFSSIDLKLNQAVESLNSEVNNLKQQTPSAVVHLPSYASVAAINTHPAPIDLTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TK33</accession>
    <name>A0AAV6TK33_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003025">
        <property type="protein sequence ID" value="KAG8172172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TK33"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10268" checksum="A1A1921C91AC168C" modified="2024-11-27" version="1">MHKFSPEKFPRGRRHGGRATRREVRREGTQARLADTVIHQLNLGAQHCAPYIRRRTATIPTKTSSDVPPPLSPSARFPTTGGKKKTSDLQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TK38</accession>
    <name>A0AAV6TK38_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase-like protein 7A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003067">
        <property type="protein sequence ID" value="KAG8172135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TK38"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14934" checksum="E40F2B471A1B88FE" modified="2024-11-27" version="1">MEVVFYGALTTLWWCFHVCPPPIPPPLEIQQVFRDRWFSFIFVRILGPIFSPINLPLRKRTFSILGKHLEGRDMSKELEVLEIGIGGGANLPVYPENSRLTAVDMNESFKKYFSDNQRSIRMLSTRGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKB6</accession>
    <name>A0AAV6TKB6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003054">
        <property type="protein sequence ID" value="KAG8172146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKB6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31555" checksum="DED8C4BF15552D82" modified="2024-11-27" version="1">MAFWNLDLLSTAMGTERRTILAFCTSQGLLPTAKFCSENHPMVLYEQEGKVGVFRCRKKHQTGKDEKKSRADCIWFSLSKLPAKKIIYLSYCFSLDYSYDLAIRETSCLISKTSTETVADWYSSGREIVVAHLLDRQAADGPIGGAGKIVEIDESKFGKRKYNVGHVVEGSWVLGMYERDSKEFRLEVLLSGLGDPITGAHTQTIESNWRTVKHHLRQSGQPREKLADRLLEFLWRRELRLKPEDPFNAFLEVVKQYYPVATAGFSEHLYVILTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TM27</accession>
    <name>A0AAV6TM27_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002643">
        <property type="protein sequence ID" value="KAG8172516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TM27"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8988" checksum="F048A64C2C75ED2A" modified="2024-11-27" version="1">MQGFSLKENTKNVKPKRELPTAAGLFAGNRDGVPKKCAFCKKTNHEMKDCRSACNLDLNERMARLKKCGGCFRCLRPGHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMX5</accession>
    <name>A0AAV6TMX5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002242">
        <property type="protein sequence ID" value="KAG8172916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMX5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="158" mass="18249" checksum="59A8D7B3DC775D3F" modified="2024-11-27" version="1" fragment="single">KTKEREKASVSNVDETENTNVESAVSYTSETMKLVREVVHIEEGPQKNQSRGWLQDGKRALENHRMYLRQQSSTKQNSRQEHFKIGQPSTSKANFNNNNVNEETNMEIAQAEDENIIELEIVTENIPVECDVDDFLEERVNGSTIRKNVSQRRQRLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNP2</accession>
    <name>A0AAV6TNP2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001871">
        <property type="protein sequence ID" value="KAG8173331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNP2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="402" mass="43882" checksum="B2CE1282B214A19A" modified="2024-11-27" version="1">MPPGNARSIIYPDRVRHLSIGCHLPSQRIPLVVLKRLQLQSPLTKRPIPSYTPELEYPPNKKATKEPKLPFCKRILPNRSEIVDVYAAFGSDYSFLPRPLTPPEPEDITPPEPEDITPPEPEDTPPEPEDTVSEEEIESFLAELAGETEGNAADEPQPSSSITSSFISWLSDVAQGATPLPIETTLPTVAPVQLPTVTTQDRPSPFQPSRIETAEEMIEKQRAVRALYKSIGIETNTQVSPTKSTFITVPSSSISTSSSLLTGIRTQGGKMIQLVSKRKDKEQTSQPQTFQTNLSLLSDDAGMRKAEATATLVKLDRPSPFQSLKGVKVIKSTSSPPSRVKTAEEVVEKQLAIQALNKSNGIESTSNLGKEPGYSICYPKPDGSIVSWSVTWPSYPGLTSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPP5</accession>
    <name>A0AAV6TPP5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001640">
        <property type="protein sequence ID" value="KAG8173567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPP5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="8316" checksum="49FED22A3E29A302" modified="2024-11-27" version="1">MASSETKPDPAPSPGDLGTAHNSATISASTSPRSDTMWSPMFCPSQASSLPTFEYTLGTLLRKSFSVDVTVDPPLPGTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPV0</accession>
    <name>A0AAV6TPV0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001526">
        <property type="protein sequence ID" value="KAG8173713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPV0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="127" mass="14584" checksum="601FAF1769BA6BD1" modified="2024-11-27" version="1" fragment="single">ILAGKWVYKTVTNAHFSEERRHGRSAGGFFLPFGVYFLAHQLGEKPALYCWENKLFRKCSHPLGSARRRPIWERETFSAPGIPNDGGRQFSGFSSLTWKNPYARGNRRVSTSREEDTLPTAHRENKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQG6</accession>
    <name>A0AAV6TQG6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_000038</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001317">
        <property type="protein sequence ID" value="KAG8174112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQG6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8174112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12087" checksum="516E9557BB194985" modified="2024-11-27" version="1" fragment="single">CWEPLGYTLIAAPCSWAAGIGVYFQRISRHTDNNDDFVLGGRALAPFPVALSILATFTSALSLMGIPADVYMYGKKTWSFPTCFSSWLRFFATISSCRCSLVTTSLPCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQU5</accession>
    <name>A0AAV6TQU5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_020462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001449">
        <property type="protein sequence ID" value="KAG8173882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQU5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8173882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="198" mass="21960" checksum="FEFCCD40E88DD1B2" modified="2024-11-27" version="1">MHSVSSRWRKPKGRPNKRRRKASENALKQWQDIKTDEKENHSTDDEVLSSDAGIVTSDAEIVVKDMWSSLLKNVTCSECSSSSMQVITKSSFGLSNNLELTCGACGHSYGSTFSSNRSPLSKKFDVNNKFVRGFLSIGRGYAALETFSMILGIPAMNRKTFSNCLNELTSNNPEVKLKVLQLAWETEVALASFPNIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSS4</accession>
    <name>A0AAV6TSS4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001103">
        <property type="protein sequence ID" value="KAG8174967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSS4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="177" mass="20158" checksum="6ABA27F8BCA37774" modified="2024-11-27" version="1">MTLPPAQNDMLYIQPQHELYILSEEFLQNISTDYFSELDVEMPPPPPVNPVTSPRPETMSSQLNVEIPPPPPVNPVTSPRPETMSSQSRADMASSSEFTRKWPFQTDFVASPWTRRRQPLMKPPLESRRSLADISEAHVAKTSHTYHLMDMLGAEEMYEIKESAPDMCTEPMDLKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TT02</accession>
    <name>A0AAV6TT02_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001048">
        <property type="protein sequence ID" value="KAG8175182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TT02"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="111" mass="12620" checksum="0D98AED1E55C3178" modified="2024-11-27" version="1">MVLCQLAREIKNNPTFVFGYKGPNQRDFLLRHGFFHIVDVGTIGVPSLSLLKQLYGLPFSHCRVSLSKCALAAVQSIAAYMLQQNLIFFSLSSNSQFMCITERRDTLRSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TV05</accession>
    <name>A0AAV6TV05_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_029264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000950">
        <property type="protein sequence ID" value="KAG8175780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TV05"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="98"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8175780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="339" mass="38528" checksum="28000D62460ED843" modified="2024-11-27" version="1">MTNNRLESINGKIKSVVTKNSSLEGFISSFFSYIKSIRYERDREATTALLRVPDVFPPNSAEESYPKALLPYPFSRLLKQLEMSANTKMTEEGSLGNFTKYKGILLDVSPLTCQCLWHKSMRMPCAHVLSVRRKLNISMFDLNFCDPRWIKSNYLSVDHAFHQLPEPERQEECGISQIPDNVPKTCASRYRKLLPLLHKMADVASESTGEDFLKKDATLKQILGSRSVCGIRPVSDRPCNVKGSQLSIHLWFEHTASHGTTVIGLKRKKSCRPVPFTHKPRAERQVVMLKWFVPEAVASDALKKGKCIEEEDVEVDPTKISSSCLESFVNLDEVKHFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWG0</accession>
    <name>A0AAV6TWG0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000964">
        <property type="protein sequence ID" value="KAG8175681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWG0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053151">
        <property type="entry name" value="RNase_H-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47723">
        <property type="entry name" value="OS05G0353850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47723:SF24">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="45"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="289" mass="32575" checksum="2CF979139692F1EB" modified="2024-11-27" version="1">MPARDKSLYIGGRYVSAHDVESKNLKYFIDSAASESNINYFQNNIPSEVCAFTDGSKTEEGVGAGAIVYKDSTPVWAEMFRLNLYNTVFQAEALAIFKTLQWFKNSMYNSIDIYSDSLSSIMASAVLYPGSPIVLDIQNLCKDMINKSINIYWIKAHVGIFGNEVADALAGAAHDLSKHTENIKIPKSFLKKTLKDETLIRWQEDWDSSEKGSSTPRALLGPFCWLWFRWMVDGFPAPRDKAVNPLADRPGVWPFLSCPSMPSLIVTCGAFQRFSFLTPPRKFFLKMRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TX33</accession>
    <name>A0AAV6TX33_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_014889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000868">
        <property type="protein sequence ID" value="KAG8176545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TX33"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8176545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="637" mass="72428" checksum="05CB8AC7EEA0E4CA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TY80</accession>
    <name>A0AAV6TY80_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000881">
        <property type="protein sequence ID" value="KAG8176441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TY80"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="256" mass="29710" checksum="385576A3AC401F6F" modified="2024-11-27" version="1">MEKTLSFADTARTLKKADIYNAAYTTLPQNCVYLGKDLILVVSLNDWKVDVHLCQFVRNASGELVPSENEIILSPFLWVSLCNSMNNPSFIDLPTTFESFSLVENELFLAAIENRYVSMQRCGMQNNYERYFIPGTLTMEDHQWRRLKYTSKLISDILTEYLIKHELKSWILKEAENHPYQTVINKSGAEKALKTSLCGLMKTHLDRTMNTDFYSALTKVDLKQIAYEFVQENKPLLRFIGEELFDVTDFVRQLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYJ7</accession>
    <name>A0AAV6TYJ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-macroglobulin receptor-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_001988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000848">
        <property type="protein sequence ID" value="KAG8176849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYJ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="4">
        <location>
            <begin position="374"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8176849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="523" mass="58107" checksum="9719955D26E38315" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZ95</accession>
    <name>A0AAV6TZ95_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000778">
        <property type="protein sequence ID" value="KAG8177477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZ95"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="162" mass="17998" checksum="620C633476FD6335" modified="2024-11-27" version="1">MAIQQPRYLQITRISPPPTALLLALRRPPMMSPNPTVLLLALRPPPMMSPHATTLLLLLSTSNATATDLHSQQVGTTSDCIDKGIQAIPDFANAKINTVISIPSQILTNDDYSSDTDSGSDDSDSEWEPYPTDEESDYQPEEDFSEDLQMRNLMVKRLLRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZA1</accession>
    <name>A0AAV6TZA1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_006427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000830">
        <property type="protein sequence ID" value="KAG8176998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZA1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF133">
        <property type="entry name" value="SI:CH211-262I1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Helix-turn-helix" evidence="4">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="70"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8176998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29864" checksum="8E9B8E0F2E0ACA56" modified="2024-11-27" version="1">MLRLRNGLTLDLIAYIFEISQPTASRYFNGMVECIYQKLQTVSIWPGREQVREFMPFNFRSYCPDCRVIIDCTEFKMVQPFNVVEQQLTFSHYKNSNTLKALIGIAPSGGVTFISDLYCGSISDKEFFKRSGLLQLLEKGDIVLADKGFRIEEELIEAEIGLMQPLFLKEKIQFTIEERSKNKLVSCLRVHVERAISRIKVFKYFEGSILYNSLHNINEVFFIASWLTNFNRPLITVEIAKFPEDLEESEDFTTDNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZL8</accession>
    <name>A0AAV6TZL8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000775">
        <property type="protein sequence ID" value="KAG8177540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZL8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="10252" checksum="D2B99777CA0D36C4" modified="2024-11-27" version="1">MPKWRALTVENLLNTVQKIILDDGRKNPFKNGRPGKKKWYASFLRRNPGLEPRFSQGVSKGRAIVLPTEDELLPTEEEFLVDTLSVASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZX7</accession>
    <name>A0AAV6TZX7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_020441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000780">
        <property type="protein sequence ID" value="KAG8177413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZX7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="3">
        <location>
            <begin position="29"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8177413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="332" mass="36625" checksum="90BCF87B2330AA71" modified="2024-11-27" version="1">MGVKRDRESAGLAEGPSSETITEDEAALYDRQIRLWGMDCQKRLREAKLLVIGLNGLGVDYVKNLALSGVKSITLMDETPVSETDSSSQFFAVGHDGEGRASASLELIRNLNPNVEVTVDPSPIESLPASFFAGFTAVFATAQPVKELVRISKACHEHNVKFCCGQTWGFYGYGFFDFQSYKYSRVYKDAKGEQKTDLDLSCQYNPLEESLNVAAGKGIQKRICHVYPLFNIVNAFEEQHGRLPSPSSREEDLVHLKSLRATVLQDMGLEDAKKKECTSVFGELSPVCSVLGGIMANEMIKGISGQGIPIHNFVLFDGEESWAVTAHIRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0M2</accession>
    <name>A0AAV6U0M2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CREB-regulated transcription coactivator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_013193</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TORC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000826">
        <property type="protein sequence ID" value="KAG8177039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0M2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008140">
        <property type="term" value="F:cAMP response element binding protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024786">
        <property type="entry name" value="TORC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024785">
        <property type="entry name" value="TORC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024784">
        <property type="entry name" value="TORC_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024783">
        <property type="entry name" value="TORC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13589">
        <property type="entry name" value="CREB-REGULATED TRANSCRIPTION COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13589:SF15">
        <property type="entry name" value="CREB-REGULATED TRANSCRIPTION COACTIVATOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12886">
        <property type="entry name" value="TORC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12885">
        <property type="entry name" value="TORC_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12884">
        <property type="entry name" value="TORC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transducer of regulated CREB activity N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Transducer of regulated CREB activity middle" evidence="12">
        <location>
            <begin position="135"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Transducer of regulated CREB activity C-terminal" evidence="13">
        <location>
            <begin position="630"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="407"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8177039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="75914" checksum="43BC239F166587C1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U295</accession>
    <name>A0AAV6U295_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
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            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000762">
        <property type="protein sequence ID" value="KAG8177680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U295"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140293">
        <property type="term" value="F:ADP-ribosylglutamate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140291">
        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042278">
        <property type="term" value="P:purine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="15"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="192" mass="21478" checksum="2FA2C96A48C792B7" modified="2024-11-27" version="1">MFATLDKIPTWEEQTREYKKNDILNKKVSIFIGDITTLVVDAIVNSTDSMYSGGGGVDRAIHKAAGNAFDYECKSFGQLNIGQATISGGYNLPAKFVIHTAVPHDHDRKRLEECYWNSLAVALESGASTIAFPCLCTGRFGYPNKDAAHVALRTVRKFLEENESSVDRIVFCIFMPEDVSIYEDLMNFYFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U345</accession>
    <name>A0AAV6U345_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Araneomorphae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
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            <authorList>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000701">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U345"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="14086" checksum="14ACCE4458696C9C" modified="2024-11-27" version="1">MKRDAKKNPPLSEKSCRHVCEDHFDLEKDMENYIRYKLMGGRIFLKKGVLPHRFDCQTSKKETVAASTERAAKRKPSKDPNHPDWIPSIFDFSKKNENRNKSKVARYNRVKNRNAQVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3Q3</accession>
    <name>A0AAV6U3Q3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000713">
        <property type="protein sequence ID" value="KAG8178166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3Q3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8408" checksum="474208847146898E" modified="2024-11-27" version="1">MQPTLPAEVHADCFLVRYNETIIIRPIRDLAGCNLQLSLHCTHVGRGTEDLEVIHKQSAFDSWWKLLDYSIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U550</accession>
    <name>A0AAV6U550_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000651">
        <property type="protein sequence ID" value="KAG8179065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U550"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9479" checksum="256DD68DB66C1F6C" modified="2024-11-27" version="1">MSLYNLASAVICRNTDKPNIKTLDLPKAIKDLEKNFARLAAVSEKDYDSEIEDYVLDNLIELICAGEQQDRRIVAAIQHSETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5P6</accession>
    <name>A0AAV6U5P6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_024372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000644">
        <property type="protein sequence ID" value="KAG8179168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5P6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="689"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8179168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="725" mass="82120" checksum="A3F306680779AB1E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5Q9</accession>
    <name>A0AAV6U5Q9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_026735</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000640">
        <property type="protein sequence ID" value="KAG8179271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5Q9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8179271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="62553" checksum="A6C5AED7E55F36F7" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5S4</accession>
    <name>A0AAV6U5S4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">39S ribosomal protein L11, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_023620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000645">
        <property type="protein sequence ID" value="KAG8179158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5S4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000003">
        <property type="entry name" value="Mitochondrial ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="10">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="9">
        <location>
            <begin position="88"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8179158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="202" mass="23127" checksum="B624FDAD7A2A009D" modified="2024-11-27" version="1">MSKTARRVKGFRKIIQKVIHPPYVRTWIPAGKAMPGPPLGPHIGQRNINVALFCKDFNEKTKDIKEGIPLPTTIRIKPDRTFEIKFMNPPISYFVKQAAGCEKGSMSPGPKDWAGKISLKHVYEIAKIKSQDEVFDCVPLKEVCQQIIDEARTVGVETVVKLEEEEYREFLEKRKEIVEQQTLELDEKRKAKILRQAKAQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5X3</accession>
    <name>A0AAV6U5X3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_016540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000632">
        <property type="protein sequence ID" value="KAG8179365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5X3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00188">
        <property type="entry name" value="PLANTGLOBIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="8">
        <location>
            <begin position="38"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8179365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="193" mass="22511" checksum="CCBCE975FBF86EB4" modified="2024-11-27" version="1">MGCQHTTGATGGNPENRDCQTEDQFKLDEVDDEVEVEPVTSRQKELILETWKHLVDNISNVGVITFMNLFETHPDVQDVFMPFKGLTKEELRHSNELRVHVLRVMGFMQKVVARLDEAEKADNLLRELGKNHVMYGAPRKYVDIIGPQFVYSVKPSMTDHWSDEIEESLLQLFRYMAYIMKKAMLEKYQMREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6U4</accession>
    <name>A0AAV6U6U4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_003642</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000629">
        <property type="protein sequence ID" value="KAG8179386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6U4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00188">
        <property type="entry name" value="PLANTGLOBIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="36"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8179386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="199" mass="22773" checksum="1CE167F698508C36" modified="2024-11-27" version="1">MGCQQTKNTTCDNSSSVANCHGEKDIENDIEYRIPEVNDRQKELITETWKQLVDNISNVGVITFMNLFETHPSVQDVFMPFKGLSKEELSHSTELRAHGLRVMGFVQKIVARLHEPEKTEALLRELGRSHVMYGAKEEYVDLIGPQFVFAVKPSVADHWTDEVEESWLQLFRYMAAIMKMAMAECPDNGGQCRDGHTWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6V5</accession>
    <name>A0AAV6U6V5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-binding zinc finger CDGSH type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_012881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000589">
        <property type="protein sequence ID" value="KAG8180037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6V5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052950">
        <property type="entry name" value="CISD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491">
        <property type="entry name" value="CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491:SF3">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="7">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="7">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8180037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="206" mass="23967" checksum="22D674AA309E4059" modified="2024-11-27" version="1">MITSKSFKSEASDFKEVVFVPVTTDRFILFVLFLVYILKNKLKMALMCNFQKASYSLKVFSKRVTSLHSRSVTPLSSIFHCNYSSRRTPDVSDVPELNEPPLKKFYEAYYQPGNGRVHDKKPFKLRCTKGKIYYWCICGWSHDQPLCDGKCILPEMKIKLKPVVFKPTVTRDYWFCNCKQTKNRPFCDGSHNSEAVQTANSVIRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7A4</accession>
    <name>A0AAV6U7A4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000606">
        <property type="protein sequence ID" value="KAG8179733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7A4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF9">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="144" mass="15889" checksum="874842F04F2C9CD1" modified="2024-11-27" version="1">MAVRHVTGSARIISILNGLGHCISHSAVLEYDTDLAQMQLNSIDCLPVGIVSNIFATFVWDNIEFCEETVTGHGTTHSSTNGIIVQSKMHSDLDLSSVYLKSGRKSKKMKIDPPVNDIPNYFIGQQCNPKVPEITTCDKKKLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7G2</accession>
    <name>A0AAV6U7G2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000585">
        <property type="protein sequence ID" value="KAG8180119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7G2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12523" checksum="677CA362E55961C1" modified="2024-11-27" version="1">MGHWSSNSDGVVERKYWILQCRRTVRNSLKECKNCRRFDASRAEVVRAPLPDDRVKDAAVFQIIGIDFGGSLCLRTDEKAWFVLFTCAVVRAVHVGLVLSLSTSDSFLLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8Y7</accession>
    <name>A0AAV6U8Y7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000585">
        <property type="protein sequence ID" value="KAG8180116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8Y7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22955:SF77">
        <property type="entry name" value="ASPARTIC PUTATIVE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22955">
        <property type="entry name" value="RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="138" mass="16029" checksum="8FB2FA8EAC401923" modified="2024-11-27" version="1">MNSYTAILWSDSTVALSWIKGDPNRWKTFVCNRTTENLQHTTPAQWRHCPGTDNPADHLTRGTFPSQLLSLESWWQGPKWLTDVPENWPIRDLSYHPLVEVETRKTESQSFYVATTEPIIDMSRCSSYTKLLRVTAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UC17</accession>
    <name>A0AAV6UC17_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000517">
        <property type="protein sequence ID" value="KAG8181398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UC17"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="174" mass="20744" checksum="AD1792BEED39737C" modified="2024-11-27" version="1">MVNLPLNHRVVNLPLNHRVVNLPLNQRVMNLPHNHRLMNQSLNHRVMNLPLNHRVVNLQLDHRLVNLPLIHQVMNLLLNRRVKLLCNHRVILPLKQRVVKIPLNHRLRDLPLNHQMVNLPLKLRTKKVRIHHRVVNLQLNHRVMNLPLNHRMMHQPLNHQLVNLSLNHRAVEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCC2</accession>
    <name>A0AAV6UCC2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-carbonic anhydrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_007788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000489">
        <property type="protein sequence ID" value="KAG8181907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCC2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF208">
        <property type="entry name" value="CARBONIC ANHYDRASE XA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="282" mass="32132" checksum="14ECD6B5C2B6072E" modified="2024-11-27" version="1">MYQIVGPDYWGLLNPEWKLCNRGRRQSPIDIQPKILLYDPGLSRIEVEKHKANGTLKNTGHSVRFRLDPDSPAVMVSGGPLSYKYRIHELLLHYGRSDDRGSEHTISGHAFPAELQILGYNNQLYDNMSEAMPKTQGVIGIAILFQISNVSSPDLRLITSKLNQIVHKGQTQHISSISVAGILPDTSQFMTYEGSTTMPGCHETVTWIVLNKPIYITKTEIHHLRRLMQGDEKHPKTSLANNYRPPQSLYNRSVRTNVFNHDIGDNRCFDSGKLFYKERAFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCP0</accession>
    <name>A0AAV6UCP0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_014026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000496">
        <property type="protein sequence ID" value="KAG8181784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCP0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000005">
        <property type="entry name" value="TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="442"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="544" mass="60585" checksum="4409240FE9C38DD3" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDN7</accession>
    <name>A0AAV6UDN7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000497">
        <property type="protein sequence ID" value="KAG8181766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDN7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="101" mass="11475" checksum="AAE4F60599575AB8" modified="2024-11-27" version="1">MALTAQEKMVFKNVPLVHYTKIIPINHHSQFLQSLVDRMTARLCSDSDNNGQLLQDISVLNPKNTEPNVVRYGETKVKRQRGKQSKASEIALKIQNLCQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UER0</accession>
    <name>A0AAV6UER0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_017667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000452">
        <property type="protein sequence ID" value="KAG8182689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UER0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000012">
        <property type="entry name" value="Rh type C glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF60">
        <property type="entry name" value="RH50, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="7">
        <location>
            <begin position="50"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8182689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="480" mass="52624" checksum="6E59F63C2B9EB5BF" modified="2024-11-27" version="1">MSNKNNISRPPKRVEVFTVSEGRTDNREDNMNWASKKFGFTVLTIEIFLIVIYTFFVSYDTEAKPTKENLTSPERNTIQDYYPMFQDVNVMIFIGFGFLMTFMKRYGYSAVGLNLLLAAIAIQWAIVMQGVWNTQDGQIPINIVSLTGGNFASATVLITYGALLGKASPVQLLAVCVIEITVFACNEHLGVHIYQAADIGGSIFLHTFGAYFGLGVAYMLYSKDVEDNIKEGSNYHSDLFAMIGTVFLWMFWPSFNSALAVGEEQHRSVINTFVALLACCVVTFAVSSLADKNGRLNMVHVQNATLAGGVAIGSTANMMVHPFGAMMVGALAGIMSTFGYLLLTPYLVKRFHLHDTCGVNNLHGMPGILAGIVSAIVASMADETSYGYSLYRLYPGRAPSSNSTEFHRIALVTAQLEPGSGWSATGQAYAQLEALLTTLAVALLSGITTGYIIRMPIFDPPKKDQLFDDVDYWEVPEEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEX5</accession>
    <name>A0AAV6UEX5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="18">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">JTE90_004139</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:60648"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:143891"/>
            <dbReference type="ChEBI" id="CHEBI:143892"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="18"/>
    <dbReference type="EMBL" id="JAFNEN010000476">
        <property type="protein sequence ID" value="KAG8182201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16203">
        <property type="entry name" value="EFh_PI-PLCepsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08596">
        <property type="entry name" value="PI-PLCc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17114">
        <property type="entry name" value="RA_PLC-epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000085">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000238">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046973">
        <property type="entry name" value="PLC-epsilon1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046974">
        <property type="entry name" value="PLC_epsilon1_EF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF6">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="17" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="11" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="15" id="KW-1053">Target membrane</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="227"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="23">
        <location>
            <begin position="1335"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="22">
        <location>
            <begin position="2400"/>
            <end position="2562"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="2567"/>
            <end position="2693"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="24">
        <location>
            <begin position="2759"/>
            <end position="2836"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="24">
        <location>
            <begin position="2884"/>
            <end position="2961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="322"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="773"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="828"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1110"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1569"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="2275"/>
            <end position="2394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="2979"/>
            <end position="3007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="777"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="833"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1112"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1124"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1593"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="2292"/>
            <end position="2304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="2305"/>
            <end position="2331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="2336"/>
            <end position="2358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="2366"/>
            <end position="2381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="2980"/>
            <end position="2991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG8182201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="3023" mass="337974" checksum="069067786F91D3D4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF23</accession>
    <name>A0AAV6UF23_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000436">
        <property type="protein sequence ID" value="KAG8183015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF23"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="249"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="394" mass="45260" checksum="C117907D6B98BA31" modified="2024-11-27" version="1">MEKQARHIELASRIYKEDFKNSWRICGFNLMPFQEDHPVYGPWFMLGKTRESQWSVLVTKELHDGIKNIGFRLVRGEESDTWDMVTFSLGLKFEDGRFLKCIDRQVVGKESDTYYKYLVKTIKAELKEHLNETCPAPIQRELYDHFKACRIREQSGISDLLNGKGGPCENLAWGILQESANMEYSAEESKTDPNVNPSPDDLFQQENITVVCEIEYTYMMPDPVPEKKETEKDNLFADFGHLFTSGKFSDITLKCGNFNLPCHKAVLYTQSLLFKEFLDKTPPSQQHLIVNVNFDLPTFKAVLLYMYANELDEEFSKSEDNCWKMYKAAGLFGVPGLRSFCLEVLEENDDCKVNDSRDMFDNLSVLSVDNSNQKLPVDVLAPVTNTSTQTLISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGB8</accession>
    <name>A0AAV6UGB8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000450">
        <property type="protein sequence ID" value="KAG8182743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGB8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="481" mass="49959" checksum="461BAB19F9D73C12" modified="2024-11-27" version="1">MPLEDALKLVARNFHEHIRAQKETMERERAERGPYVGGVAADREIQFLLRMLADGRWVSLAEISDVIRYLSDRRDKMKASEGGDRVLSRAPIPASDIKLDVPFKPKDDIDVSKKEQDLQNRIINIMNQGAPSPIGNSQGLSSGLPNVNLPPPRSDQSRMGDDLNNMRSQAGLGSSGMPGLKSNTSAQDGLGVEKSAARADAPFSSSAAVTNPPSDGTSPTFINFDNASVQKALDNLMQSGPNLLKSISMTSSGSTPNHSLSGNASITSIHGMGSSSNEPMEMQRGNLGPRGPGGLSNIPGGDQMRGNMPMGPLRGPDGGMSNLGRPGPQRGPGPMSSDLGGPGSQRDMSDLGRPGGNLSDMGRPGQGSDMMGMGSQRSGYGDMGGMNSGRGFNSGGGGMTDSGMGAPRMSDLGRMDRPPPGIGSGGYSGPNQFGKFQGGSGPGNFGGSYNNSGNVGNNMPPRQGGYGGSQNMGGMGGPRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGY1</accession>
    <name>A0AAV6UGY1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000441">
        <property type="protein sequence ID" value="KAG8182906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGY1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="101" mass="11727" checksum="423B14FE0F95EFCA" modified="2024-11-27" version="1">MNILRNGHSFKIDGKDYFFKAVIIGTPADTLASNQLWGFKEGVAKAKRCWRTCVADRPYIFEKFFEEDFALRTTIDHLEKCDDLEEASPKTKKTNQQNLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIC4</accession>
    <name>A0AAV6UIC4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_008913</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000386">
        <property type="protein sequence ID" value="KAG8184132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIC4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8184132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="647" mass="73674" checksum="7699F71D04A951D6" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIJ2</accession>
    <name>A0AAV6UIJ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000413">
        <property type="protein sequence ID" value="KAG8183573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIJ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35846">
        <property type="entry name" value="PROTEIN CBG05131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35846:SF3">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="677" mass="76515" checksum="60F887F0056D12C5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJ75</accession>
    <name>A0AAV6UJ75_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000402">
        <property type="protein sequence ID" value="KAG8183834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJ75"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9508" checksum="CADAF301CCFFDAFE" modified="2024-11-27" version="1">MSYINACLACPFTCIPGKGTHDNNNLQNLKRSPLISVLFQLGIATSTELARLDLLVVVVKVLNSIESKLFLFFLNNVHSFRVALDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJH5</accession>
    <name>A0AAV6UJH5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_006774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000375">
        <property type="protein sequence ID" value="KAG8184371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJH5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8184371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="135" mass="15556" checksum="F0DE89D310395633" modified="2024-11-27" version="1">MKAKSETHWVIEIDPKSYESLAKISYVFINFKKCPLEPFVSVNHCKKCGKYGHTAKRCTESTPKCLKCGLSSHDNDQPCSFNCLNCSTNNSKLKRNEPTNHKSGYYRCPEFHKQRRQAFLRSGHDPGVWERVILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJI1</accession>
    <name>A0AAV6UJI1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000374">
        <property type="protein sequence ID" value="KAG8184407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJI1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="11047" checksum="438AE4C114120C90" modified="2024-11-27" version="1">MKSSGGLTRGRGITDSLPTRWTMGLAAFQNVCAEVENYCSCLSATTDQHIDMRCSRIRRDDDDATKLTEWFSNHNPFPNSPHLMSISSGLIGGEDVNCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UK78</accession>
    <name>A0AAV6UK78_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_012621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000370">
        <property type="protein sequence ID" value="KAG8184532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UK78"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="36"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8184532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="329" mass="36083" checksum="A11FA6FA29FD8D8F" modified="2024-11-27" version="1">MPSPVQNQPPLYQTTSPQNPPRRTSQQPARVSVKAPPFWRKNSEIWFQQIESQFELANITAELTKFHRVVPALQPEELSIVGVDLIITPAPVTPYTAIRNRLCAQYADTEDERLRELISGLQLGDKKPSRLLLDMKSKAGTDQRDPAEVTASPAPSQPRSADFSNFNGNVGQRGDISAPDAAGDFVQAESVGSTPPLHVKMTRKAERSPAICKPPSSQLAILLVPPSFRKKKSLKLQTTVFLGAGKLREPSLNPVGDGRAEMFRLYIKDKSTAAQYLIDTGVDVSVSSDTSHGCRETSPSRQTSVVCSKQNTYLNLWLKTLTAGFGFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULZ0</accession>
    <name>A0AAV6ULZ0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Swi5-dependent recombination DNA repair protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000363">
        <property type="protein sequence ID" value="KAG8184734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULZ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042429">
        <property type="entry name" value="SFR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28643">
        <property type="entry name" value="SWI5-DEPENDENT RECOMBINATION DNA REPAIR PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28643:SF1">
        <property type="entry name" value="SWI5-DEPENDENT RECOMBINATION DNA REPAIR PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32470" checksum="87C80AF5A7F2782D" modified="2024-11-27" version="1">MEEDINVKESDEESRGCISLTHSPYVGGNKMSSSLKDRLKRSRMHSSPLSRPSSSSFTTPVAPRSIPFANFNSSKEDSSLSVRQDSQNTMNEPCKNEAESALNIGSDFFICEKDSKVSNALVITETFQETSLEIGDNSSENPDVVLEHAKNTPITEVHQNIFDKPYGEIKEKASLNPIYSLKTDSEKANPNANQNLCLYSKEDIENAGDIEALHTMYSNLKKQSHEHEETLRKLKLVQQHHTKNNPDALNSLTTKWLRCTQLSLKRLYDLMPEPQKEEFYRKTRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMA6</accession>
    <name>A0AAV6UMA6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000375">
        <property type="protein sequence ID" value="KAG8184366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMA6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="128" mass="14788" checksum="CE42122000C99441" modified="2024-11-27" version="1">MSLFAPSLSKSVFLFRIGTETLPASQVIFTFRRMVLRSRTRRLSERSNSSVITDQDPQDLRCELEAAQSKITTLEKKNRRNDKFHAGKSKELCAISSGEGFPSVFLYYKKRIIARCCQNYRDGLQRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UP63</accession>
    <name>A0AAV6UP63_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000315">
        <property type="protein sequence ID" value="KAG8186057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UP63"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16000" checksum="96A0E89B20CFAF64" modified="2024-11-27" version="1">MVGLRHLPTFFVLRARKNFVKENSLCENCLRSHPRSSCTSSNCRRCNKSHNTLLHEDSTEVQAASGDPEVAQPETTSHFSRYPPSRQVTLMPTAIIEVLNIYGQKQPCKMLMDSGSQTSFISERCNSESHQALYPSGPSLQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPI3</accession>
    <name>A0AAV6UPI3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-CoA dehydrogenase 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_012001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000310">
        <property type="protein sequence ID" value="KAG8186177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPI3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF6">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="49"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="167"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="273"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8186177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="47600" checksum="012420A4DAB2D698" modified="2024-11-27" version="1">MGFLTFFSVSQGSIRSKMLKLARQCLHLSQKNFAKSFHTSNIRSALVFTQEHDELRKTVQKIIEKDINPFVDEWEEANIYPAREVFKKLGNAGLLGITRPTEYGGLGLDYSFTVAFIEELTKINCHGVPMSIAVHTDMATPALAKFGSEELRQEFLVPSIAGDRVSCVGISEVQAGSDVAGIATKAVRQGDDLIINGGKMWITNGAQADWMCLLANTREGPPHKNKSLICVPLDLPGISFQTNKKLGTCSSDNVQFFFDNVRVPAKNIIGEEGMGFVYQMIQFQEERMAGVIGVAPGCTRIIQETIEYCKERKAFGQPIIDNQVIHYTFAELQTEVEALKSLVYRAAAAMIDGEDVTLLASMAKLKGGRLVREVSDKCLQFWGGMGYTPEVNISRQWRDMRLLSIAGGSDEIMCAIICKYMGILPKLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URV3</accession>
    <name>A0AAV6URV3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000282">
        <property type="protein sequence ID" value="KAG8186985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URV3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="10088" checksum="B0D203EF385D064F" modified="2024-11-27" version="1">MNMQEQMCHLTPTKSNSKRKNILKTEEFDSMVRQTIQLINIVNANFTASAAKITGTAPRETETYTFVYEGALFRKSVVSVNVSGDRQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6US31</accession>
    <name>A0AAV6US31_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000284">
        <property type="protein sequence ID" value="KAG8186934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6US31"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18209" checksum="A62E195DEC27257E" modified="2024-11-27" version="1">METPTMGFLNSDCNRGGSRIFVTYPEGSISRHKIPAGNITSNFTIEPVAIKEALSIYLTRITINPSDGKVIFTDCESTLRVLQKGNTNHVQKINTLLFSIEEKRRYVYTSMDPGTRRRQGERRGRLSGQEGEEDHPDYNVIRRKTKALHYSSKKNFPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6US95</accession>
    <name>A0AAV6US95_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000310">
        <property type="protein sequence ID" value="KAG8186181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6US95"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043742327" evidence="1">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="139" mass="15912" checksum="6AA503DEDACCD895" modified="2024-11-27" version="1">MAIVVKSLVVLFAICFLWISVAAEESLSDDEKFAKFQKHLCEDRNRTFNEDMNSCFLTEPQAVIDASKDCVDRATPGLNGNLVDFLETACHDKEAYLKFDACNKEYEGKEEYRSQMEVDQNTVDCYNKMLTKYNLPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU58</accession>
    <name>A0AAV6UU58_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000281">
        <property type="protein sequence ID" value="KAG8187055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU58"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10548" checksum="9062AC1887DED3BE" modified="2024-11-27" version="1">MSQACVRASRKRDLDFTWQKRVFFFTSPCGEMFVWRQPFESRSSCRVIGSFQKVPLVCDLPLPTTLTPLTVALWVTSLGCTKIFRLFYVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWH3</accession>
    <name>A0AAV6UWH3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000233">
        <property type="protein sequence ID" value="KAG8188680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWH3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="130" mass="14538" checksum="4A1ACB3B1E5D5D3C" modified="2024-11-27" version="1">MGEANTPLRPKIIFLSTTAPLGYSKISPSRMDVKKCPPFMSRPPVYIQILTGHLLLPLRISGVSKSGHSIRGRICQTLNMSQGSIKGGEKVFLNLDKEQGGILWVRWFWVDIWNPGDIWNSPSVDDMSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWW2</accession>
    <name>A0AAV6UWW2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1</fullName>
            <ecNumber evidence="11">3.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_004643</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:75163"/>
            <dbReference type="ChEBI" id="CHEBI:78907"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:42305"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42584"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82605"/>
            <dbReference type="ChEBI" id="CHEBI:82606"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65221"/>
            <dbReference type="ChEBI" id="CHEBI:78911"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:42309"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:33751"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="EC" id="3.1.3.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33752"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78930"/>
            <dbReference type="ChEBI" id="CHEBI:78931"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42321"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.27" evidence="11"/>
    <dbReference type="EMBL" id="JAFNEN010000229">
        <property type="protein sequence ID" value="KAG8188830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWW2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14524">
        <property type="entry name" value="PTPMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000060">
        <property type="entry name" value="Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042165">
        <property type="entry name" value="PTPMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044596">
        <property type="entry name" value="PTPMT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46712">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46712:SF1">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="25"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="97"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8188830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="177" mass="20714" checksum="E0BDB37628549CE9" modified="2024-11-27" version="1">MLARATFYPSLFYNVVMERLSSRAWYDRIDENIILGALPFRTITEKLIEEENVRGVISMNEDFELQRWVTTEEEWKKKGVKFLQLHTQDIFHAPSQEKLARGVQFINDFIGTGSSVYVHCKAGRTRSATLVGCYLMNRHKWTPKEAVDLMRQRRAHILLGTKQLDALDIYYKNNVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXF5</accession>
    <name>A0AAV6UXF5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000221">
        <property type="protein sequence ID" value="KAG8189127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXF5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="10288" checksum="C452F6C1611A4DDB" modified="2024-11-27" version="1">MAFRRNVIYAIFISVSFRRLPIMLEKHAWLRDIPQKKPFFTITKKRPPQTGPPKGFEERPKGVVRMECPPEHSSFGDVPHEWNAVEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXI7</accession>
    <name>A0AAV6UXI7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">JTE90_004769</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000237">
        <property type="protein sequence ID" value="KAG8188537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070776">
        <property type="term" value="C:MOZ/MORF histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048589">
        <property type="entry name" value="SAMD1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF217">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21524">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V192</accession>
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            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
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            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
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    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="EMBL" id="KAG8189763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="158" mass="18175" checksum="1C7D3D6467F278B5" modified="2024-11-27" version="1">MILCTRKSKVAAAASHCLKSVPCICCIPRKMHSLLFNGVRRALEQGSKLKDLHQEYCINGVISIIQRSTLPKESHPNQFPILGDEFAIERNKISNKNRKGPKIKGKYAGHFHVFYIENTGLWEERIFQKKFPRRREIEFFFCETTFREAGINCCGNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1V7</accession>
    <name>A0AAV6V1V7_9ARAC</name>
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        <recommendedName>
            <fullName evidence="5">SEC14-like protein 2</fullName>
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        <name evidence="3" type="ORF">JTE90_000118</name>
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            <taxon>Chelicerata</taxon>
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            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
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                <person name="De Corte Z."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
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        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="75"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="2">
        <location>
            <begin position="267"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8190022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="46549" checksum="7EF9157989600E77" modified="2024-11-27" version="1">MSGYMGDLSPTQEKALEEIRTIFAGQLNSRQDDYLLLQFLRARRFDVKRTEEMLRKHLQFRDKFPEEYFLTEYQPPELLTKHLLPPLLGYDKEGCPVRIIHIGHQDVRGLVCCVRRPEIRKCITWFLDTDKEAMRKRSKETGVHIETRTFIFDLEGLSLRQIYHKDVYDLVLSFLRLYEGNFPENLKVAYIINTPPFFSWLFNMVKSLLTEDTVKKLKLFGYSGWKEELLECIDADVLPVIYGGTRTDPDGDPKCPSMIRVFSPIPKKYYLSNTNRLNPDSDPKVSRVQVGRRSKHSVPIRVDVSGSTVSWDIDVRAADVRAHLVYEGGATPEVVVEPVLVSGEYGTENGCYLAEKTGKYSLVLDNSYSLLRNKTVFYRIYVSTCTVPSSKELNANDKSCLITVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2F7</accession>
    <name>A0AAV6V2F7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myosin-M heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_004202</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000176">
        <property type="protein sequence ID" value="KAG8190699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000038">
        <property type="entry name" value="Myosin-M heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF5">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="1070"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1410"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="690"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="747"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="818"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="833"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="854"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8190699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1466" mass="165545" checksum="904C5066C50EFB9F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2Q3</accession>
    <name>A0AAV6V2Q3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000172">
        <property type="protein sequence ID" value="KAG8190889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2Q3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="253" mass="28541" checksum="A1274A9507DD51DF" modified="2024-11-27" version="1">MEQGVLRPSKSPWASPIHFVPKKDNTWRICGDFRALNKVTLPDRYPLPHIHDVANGMVERWHRVLKSALISVDPIHWSEALPMVLLSLRTAIREDLQASPSHLVYGSSLRLPCELFQGRKLSGVPQADFVHLLRTHMATLRPTPATDHGKHSPFVQKDLENCTHVFLRTDRVKKPLESPYQGPFLVTRRTNKVFTILLDSNTETTVSIDRVKPAYILPERSADSGDAPTLNSSSPLVQTKSGRISKPPVRFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V554</accession>
    <name>A0AAV6V554_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ADP-ribosylhydrolase ARH3</fullName>
            <ecNumber evidence="7">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ADP-ribose glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">ADP-ribosylhydrolase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">O-acetyl-ADP-ribose deacetylase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Poly(ADP-ribose) glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">[Protein ADP-ribosylarginine] hydrolase-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">[Protein ADP-ribosylserine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">JTE90_020676</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:77017"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="25">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="25">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="7"/>
    <dbReference type="EMBL" id="JAFNEN010000159">
        <property type="protein sequence ID" value="KAG8191421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V554"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140290">
        <property type="term" value="P:peptidyl-serine ADP-deribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4080.10:FF:000001">
        <property type="entry name" value="ADP-ribose glycohydrolase ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF24">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 25" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="25">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00042850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00043187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00043193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAG8191421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="348" mass="37989" checksum="AB430814DF420E98" modified="2024-11-27" version="1">MAEEVSAGLLSKFKGSLIGALVGDCLGAPFELKGKVSPKVLEKYINNLLNKGSKQIISYTDDTSMTLSIANSLVENGKVDPKDLAQKFVTEYLKPEYRCYGLHVVRVFQALKETDFEDVFLPAKAQFNGSGSYGNGAAMRIAPIALFGCQETDEFLKDAVERCSKVTHTHPDGYNGAILQCFAVHAALKSDSSKDLDPVDFLTQLENRMKNIETNKSAAPFCESLKKIKDIYLKNQEDISATEIAEYLGNGETAPRSVPTALYSFLRGMKPIPHFKCSNPFVRTIYFAISVAGDTDTIACMAGSIAGAYYGVEIIPEKLYKCCEAVDQVSKVAELLYAQDCQSNVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5I1</accession>
    <name>A0AAV6V5I1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5I1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="115" mass="12467" checksum="DE3F1176F3BC4D2C" modified="2024-11-27" version="1">MTSRLFQQVYRGLVTPLVTPKTNFPPNTGSLMSTTTGSPKSSSNNDMAMNVLKIGGGFAVGMYTGHVVTEQGIVPMDKMYGKDTDKEEEDKSEDKDKGKEAEDKGEEAKDAAKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V618</accession>
    <name>A0AAV6V618_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Iron-binding zinc finger CDGSH type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_006105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V618"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052950">
        <property type="entry name" value="CISD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491">
        <property type="entry name" value="CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491:SF10">
        <property type="entry name" value="IRON-BINDING ZINC FINGER CDGSH TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="6">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8191360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="124" mass="14088" checksum="10DB5C815B5B2E6F" modified="2024-11-27" version="1">MSVLNCLKRFPLQTRALFVNPTSKFSSEVVVKGVIAKRIPTYIELKADKTYAWCSCGLSKKQPFCDGSHQSDPNGLKPVKFTVAKAGRYLLCRCKQTNNRPYCDLTHVKTFIPESIRNMMKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V635</accession>
    <name>A0AAV6V635_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_007743</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23956"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52424"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.41" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000149">
        <property type="protein sequence ID" value="KAG8191947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V635"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23433">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000047">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF101">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0430">Lectin</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="17">
        <location>
            <begin position="180"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8191947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="315" mass="36221" checksum="44C29348A9EBE49D" modified="2024-11-27" version="1">MQDTLGLRIHFPFLYCRTTLFPTSSPVGSTLFFLRDNESTPTMAGGLFSIDKDYFEKLGKYDEGMDIWGGENLELSFRIWMCGGTLEIVTCSHVGHVFRKSTPYTFPGGTSKIVNHNNARLAEVWLDEWKEFFYAINPVAKKVAAGNVTERKELRKNLHCKSFRWYLENIYPESQMPLDYYHLGEIRNEITNKCLDTYNRKNGENVAVSHCHGMGGNQHLLQVFAYTKRKQIMSDDNCLDASSHRGPVKLVRCHGMGGNQLWGYDDMDKTIRHVNSGKCLDKPEPKDLTLPVLRDCDGRLSQRWIMKGKFKWQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V715</accession>
    <name>A0AAV6V715_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000139">
        <property type="protein sequence ID" value="KAG8192432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V715"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043709003" evidence="1">
        <location>
            <begin position="25"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="96" mass="11250" checksum="8CB077FC2299AFF9" modified="2024-11-27" version="1">MFRRNLLSLLLAVALILLSNFSQSEVSGAMIGANRHLLEVGDTGNYQQQYLRTMNPSRRFRVPRPPTELELLNALRKRQIRYHPCYFNPVSCFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8H8</accession>
    <name>A0AAV6V8H8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000150">
        <property type="protein sequence ID" value="KAG8191906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8H8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="187" mass="21152" checksum="C9D7ECA4C1018F6B" modified="2024-11-27" version="1">MTRSEVKSIRVTPPPPDLEFNKDEINEMSSREKSRGDGEERDAGWAVYTPKQLWGPNNNKTKWQKEMETPSPSSFTASLQPQLMTDRKKVIISKLDSQSKYQPNDKPQLSTTNKQKKDKHSFNHNNKNRYGRQQKPQLSSADSAIAHFQPGPPTSKAFSTAFIRGCWHGVPAPLLEVLKIEVPAPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8K5</accession>
    <name>A0AAV6V8K5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000146">
        <property type="protein sequence ID" value="KAG8192063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8K5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="9072" checksum="2F91D8793999B355" modified="2024-11-27" version="1">MSLGEKALKKAVSAQNVPKKRNRKPVLINCRSISANGAESFDDGLAERWIPIKLNSEVKDLEKEEFTMVRRVAGMEWQNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VC23</accession>
    <name>A0AAV6VC23_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ephrin RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_024534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ephrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000106">
        <property type="protein sequence ID" value="KAG8194202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VC23"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046875">
        <property type="term" value="F:ephrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02675">
        <property type="entry name" value="Ephrin_ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031328">
        <property type="entry name" value="Ephrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001799">
        <property type="entry name" value="Ephrin_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304">
        <property type="entry name" value="EPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304:SF29">
        <property type="entry name" value="EPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00812">
        <property type="entry name" value="Ephrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01347">
        <property type="entry name" value="EPHRIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51551">
        <property type="entry name" value="EPHRIN_RBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ephrin RBD" evidence="9">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8194202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="324" mass="36472" checksum="017EED899ED297BF" modified="2024-11-27" version="1">MPDSGYSSKKSAGYLYFARRGAEVHLHVNFRIDNTDHIIDVNKNNLPFEYDQVNIICPVYPHSNPGTSTEEENEEEEQYIIYNVSKEEYDSCRITNPNPRIIAVCDKPNQLMYFTITFRSFTPQPGGLEFVPGHDYYFVSTSTGDPEGLHQRMGGRCATHNMKVIFKVCCNPSSKPGIEDGSVHKTSPSNSSAPATPSSTIIHNTSSRPLNEVKSPFDRNYIHPPSVPASQATPSPKGMRPVTRIPPPPYHMRPYEVPIEDEMDRSPPADKNKEEVSKPPKRERAKNEELAGNAGPPTHRWSNGAYYCIVACLLYRLLQSLLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFR1</accession>
    <name>A0AAV6VFR1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BK channel</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Maxi K channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">JTE90_017277</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. Slo sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000098">
        <property type="protein sequence ID" value="KAG8194844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFR1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060072">
        <property type="term" value="F:large conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000035">
        <property type="entry name" value="Calcium-activated potassium channel slowpoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000005">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000015">
        <property type="entry name" value="Calcium-activated potassium channel subunit alpha-1 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="22">
        <location>
            <begin position="359"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="22">
        <location>
            <begin position="903"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="730"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG8194844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1253" mass="138289" checksum="4EC57951B3A1E441" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGH9</accession>
    <name>A0AAV6VGH9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000077">
        <property type="protein sequence ID" value="KAG8195822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGH9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8195822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="175" mass="18936" checksum="AA48F37B46AF7E92" modified="2024-11-27" version="1">MADLEKSDSDSHPENNLSWDLPSSSMSSGQLTDDPTRPYRKKYRSKSAVSTDPRSPYYTSQGFTVKDDPFKHGFTKAPSVSCVPGYDGHKYAEAASKSQLPFNGGIVGLNLSPDDPKAATIRQHYYPEGGWGYVVVVCAFLVEVISGGLQASFGLLILSVMSTFGKDATLVRTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VI56</accession>
    <name>A0AAV6VI56_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_013794</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000072">
        <property type="protein sequence ID" value="KAG8196309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VI56"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="202"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8196309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="241" mass="27175" checksum="715B00E8A345926F" modified="2024-11-27" version="1">MIYGKIRENLGKVNLDGINEVHAQCQLKVRLVSESMLFSSVTVRLEDMTQTQFLSPLFDYFLEGVAAIVPCPKDHIFIFNVQDDTDVDAKILNVSFSVRRPGSRDPDDYYPPHYLQERVYLNRAILARLANVKVLPFDDNLCVREPCVNFEECLSVLKFGNASGFIASDTLLFRPIYPVNTFACRCPKGFTGMKHKYECDTEVNLCYSSPCGPNGTCIRKEGGYTCLCRDGFTGKAYCHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIT1</accession>
    <name>A0AAV6VIT1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000069">
        <property type="protein sequence ID" value="KAG8196519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIT1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="66" mass="7419" checksum="F4016C99A1DC0266" modified="2024-11-27" version="1">MNQRESSNPSPNSPETTEVLFFIFLITFSLSPPPPCFLEGRGRDPPPKTEAYSAALLLFQDIQKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VK73</accession>
    <name>A0AAV6VK73_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_003572</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000068">
        <property type="protein sequence ID" value="KAG8196558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VK73"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043686600" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="10">
        <location>
            <begin position="25"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8196558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="195" mass="21294" checksum="8FDF98ED407258DB" modified="2024-11-27" version="1">MLSSFQTQVAVVIAFFLCWTPFHAQRLMAISIQEPTDTDFIVYSFLTNISGLCYYVSATINPILYSILSLKFRHAFRDTIGRCLGKGVQLGRRGGGRSSRTMSFFNSTLKTGLEMTDDVTVVSDVPEGQGSSNGGRKVSRLGVSHLVMKSSPAEPGSVKKLKKASTISTASQQLVEAFDDATVSDYIDQMKETQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKB4</accession>
    <name>A0AAV6VKB4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_012309</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000069">
        <property type="protein sequence ID" value="KAG8196493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKB4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071140">
        <property type="term" value="P:resolution of mitotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090656">
        <property type="term" value="P:t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058766">
        <property type="entry name" value="HHH_XRCC3_RAD51B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26169">
        <property type="entry name" value="HHH_XRCC3_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="84"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8196493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="330" mass="36844" checksum="5C17B75B60C82795" modified="2024-11-27" version="1">MSSAPLPKKPKLSLEVDDLSIHPQLIQKLKEAKLFTFKAVLHLSEAELQKNVKVSVNEANQIQKAVSQVLLLSQVLSAHCISNEERPYTKHKFSLDLLSSAGDNVDGIYTGTITEICGESGCGKTQVCLHLSIHAQKQLSMGGLDTKVIYIHSEGEFPIKRFMQMADSFKEDNPCFQELNLADNLILKKVFNFQQLMHVLQKGIPEFLNKLNHPKVIIIDSVAAVLRCEYETLSSRTLMIQKLALEVWKLANLYGMAVICVNQVSGSNKSTFDVPSLGLLWSNILTTRIRISRKPSEQSRTLRTLDVVYSSYLPNISTQFTISEAGVKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKS4</accession>
    <name>A0AAV6VKS4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eclosion hormone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000064">
        <property type="protein sequence ID" value="KAG8196761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKS4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008255">
        <property type="term" value="F:ecdysis-triggering hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018990">
        <property type="term" value="P:ecdysis, chitin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006825">
        <property type="entry name" value="Eclosion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04736">
        <property type="entry name" value="Eclosion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043585817" description="Eclosion hormone" evidence="1">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8593" checksum="CB03993F57019571" modified="2024-11-27" version="1">MAGLKHLLCILVLLAVFDANLSLNPTNVCLKNCAQCKLTFGSYFNGPKCAESCIKYRGLLMPDCNDVKTIHGFLNKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VL72</accession>
    <name>A0AAV6VL72_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_009056</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000070">
        <property type="protein sequence ID" value="KAG8196426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VL72"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8196426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="106" mass="12248" checksum="27ED33E746CBE1F7" modified="2024-11-27" version="1">MLVFIPVSKPDVCEQWGKSFNERSPSQTYRFKPSKGDLHKHVRIHTGVKPYQYELCNKTLTQKPDLQSHFLTYTGVNPHVCNVCHEAYLDRSTLQKHVLAQHSVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMZ1</accession>
    <name>A0AAV6VMZ1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000045">
        <property type="protein sequence ID" value="KAG8198029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMZ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="145" mass="16940" checksum="BB3C89D62594219A" modified="2024-11-27" version="1">MWRWWRISDVMRWWRRISDVIPPPTTASPELYTYQPKERQTHVSFPVKSRGCAKYSTWWAAQREGSTTNLVNGDELSNRERERKSSLLCVGYQFPTTEEATRHSTPFSAGSTYIHTKPAMSCTLLRIEKVLAKDHFEETSRLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQT7</accession>
    <name>A0AAV6VQT7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial proton/calcium exchanger protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Leucine zipper-EF-hand-containing transmembrane protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">JTE90_021047</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LETM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000032">
        <property type="protein sequence ID" value="KAG8199034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQT7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059005">
        <property type="entry name" value="LETM1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26561">
        <property type="entry name" value="LETM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="23">
        <location>
            <begin position="228"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="652"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="711"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="442"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="524"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="711"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAG8199034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="748" mass="85752" checksum="397284A9421AE276" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRM3</accession>
    <name>A0AAV6VRM3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000028">
        <property type="protein sequence ID" value="KAG8199334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRM3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8038" checksum="0EBCE38145581BAD" modified="2024-11-27" version="1">MPLGPTAQIIFQFGLSHQVKMARCILLSKVAQSDQTSTTSELHDIFPITDDLIYQNVLGVIIKKLVIRTIGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRX4</accession>
    <name>A0AAV6VRX4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nephrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_007119</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000035">
        <property type="protein sequence ID" value="KAG8198816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRX4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043563387" description="Nephrin" evidence="8">
        <location>
            <begin position="18"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="16"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="170"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="253"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="351"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="448"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="545"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="685"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8198816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="772" mass="85044" checksum="B5AC018A1858308B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT72</accession>
    <name>A0AAV6VT72_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_015093</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000034">
        <property type="protein sequence ID" value="KAG8198879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT72"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="241"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8198879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="294" mass="33883" checksum="73AC627C8C0B1E59" modified="2024-11-27" version="1">MNKPQSAGTSEILRSSQKDEEYLHYLRSLVADITQRCLGIPIWIKWREFSNTFSDALFYSLTTLSGLQTLGEEYSNIIQVNRTLKSVPPRWVRMTDVSFRTFGCYFLLKLQTWLEKEIAELSSATSEEDDPLLVNIKEYLPAVFKALGVMQRLHLIVFYLYGNYYSISKRLTGIKYVVIRRWLAKPDQQLSYKLLGWIAATQLCLSLAVTIYSKSTKSSLDSSTQLHSETSEELVTSKNQCSLCFEKRNSSTATPCGHLFCWSCITSWMQNKEECPLCRESFPPSKLILLQNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTZ7</accession>
    <name>A0AAV6VTZ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dystonin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_018921</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000019">
        <property type="protein sequence ID" value="KAG8200134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030056">
        <property type="term" value="C:hemidesmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21189">
        <property type="entry name" value="CH_PLEC-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000001">
        <property type="entry name" value="Microtubule-actin cross-linking factor 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.20:FF:000001">
        <property type="entry name" value="Microtubule-actin cross-linking factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000022">
        <property type="entry name" value="Short stop, isoform K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000040">
        <property type="entry name" value="Short stop, isoform N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000042">
        <property type="entry name" value="Short stop, isoform N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1290.10">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041615">
        <property type="entry name" value="Desmoplakin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035915">
        <property type="entry name" value="Plakin_repeat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF23">
        <property type="entry name" value="SHORT STOP, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17902">
        <property type="entry name" value="SH3_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21019">
        <property type="entry name" value="Spectrin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14102" checksum="882B807EAD450AB1" modified="2024-11-27" version="1">MTNGDRYASGIAYQRPHQITKKASCQMPFGNGLATRLDVVVKRKTPSKIKVTQHTTTTTPRTNKTVPSIAHSEKENCPPIFDMGHSLLPFSDHADKLLQSSLKIYASSLSLAGHPQVRDLALSIGYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVS1</accession>
    <name>A0AAV6VVS1_9ARAC</name>
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        </recommendedName>
        <alternativeName>
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        </alternativeName>
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                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
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    <comment type="function">
        <text evidence="8">Putative sodium-dependent amino acid/proton antiporter.</text>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
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    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="13">
        <location>
            <begin position="48"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8199869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="465" mass="50925" checksum="8F42D85F7E2F3E14" modified="2024-11-27" version="1">MATESTYILSDSNSVKSPQETNDTVGSTEDVKQLIIDDGPKNLKCNLAQTSFNYINSVIGSGIVGIPYALQQAGLGMGIILLLLIAVATDYSLCIMIKAGTAAGVTTYQALIQSQFGRPGYYFLTVAQFIYPLIAMISYNIIIGDTITKVLMRMFDVSRTSLLGNRHFIVLISTIFVTLPLSLYRTIVRLSLVSFLSLLFAVSIVVFVVIRAFTMAGEIAITPNAFQFVNSGFTEAVGVIAFAYMCHHNSFLLFDVLDNPTQKRWNLVTHISIGLSCLIIVVFGICGYVTFTGSVQGDLLENFCLSDDWANAARWIFTITIMLTYPIECFVTREVFENAFFKEKQSSLLRHSILTISLVVLTFALSTLTDCLSIVLELNGVLAAVPLAYVLPAAAFIKVTGKPYITKEKIPAILLATVGLTIAVIGTIKSFLDMWNGVSCSHGEKHESLDSDLVVQSIDVFYPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VW97</accession>
    <name>A0AAV6VW97_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_001936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000020">
        <property type="protein sequence ID" value="KAG8200079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="494"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="476"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="540"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="672"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1911"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1964"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1965"/>
            <end position="1974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8200079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2095" mass="235560" checksum="10868136893CFE24" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VX81</accession>
    <name>A0AAV6VX81_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_016850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000006">
        <property type="protein sequence ID" value="KAG8201374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VX81"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14698">
        <property type="entry name" value="bZIP_CNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.880.10">
        <property type="entry name" value="Transcription factor, Skn-1-like, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047167">
        <property type="entry name" value="NFE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411">
        <property type="entry name" value="NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411:SF55">
        <property type="entry name" value="SEGMENTATION PROTEIN CAP'N'COLLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043775843" description="BZIP domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="655"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="750"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="673"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8201374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="773" mass="87751" checksum="E93BC7E38D1D7536" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXA9</accession>
    <name>A0AAV6VXA9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_016875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000006">
        <property type="protein sequence ID" value="KAG8201404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXA9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06681">
        <property type="entry name" value="PDZ2_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06684">
        <property type="entry name" value="PDZ3_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06682">
        <property type="entry name" value="PDZ5_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06683">
        <property type="entry name" value="PDZ6_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06685">
        <property type="entry name" value="PDZ7_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000021">
        <property type="entry name" value="Glutamate receptor interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000023">
        <property type="entry name" value="Glutamate receptor interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043545">
        <property type="entry name" value="GRIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227:SF2">
        <property type="entry name" value="FI03335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227">
        <property type="entry name" value="GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="46"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="146"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="246"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="365"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="463"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="562"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="885"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="792"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8201404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1012" mass="110861" checksum="FBA6E09B71C9383F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYH2</accession>
    <name>A0AAV6VYH2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYH2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12439" checksum="1C8A6F30ADD2AD65" modified="2024-11-27" version="1">MNLIHNMPWTLTMCLQDPRKISLAYKMCNQQFRRKCALESHNKMHADEMCEGLLTLEHSESDESSDSEKKNLLIVLGKCGNQAYLKADKLCPPEVNLNDPMQIVRTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W0E6</accession>
    <name>A0AAV6W0E6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ras-related protein Rab-39B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_016795</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle membrane</location>
            <topology evidence="12">Lipid-anchor</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000006">
        <property type="protein sequence ID" value="KAG8201316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W0E6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000358">
        <property type="entry name" value="RAB39B, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8201316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24478" checksum="5A0B190F4EA69EA0" modified="2024-11-27" version="1">MVEPIFDYQFRIIVVGDSTVGKSALLRSFTEGKFTEICEPTVGVDFFARLIEVQDGVRLKLQLWDTAGQERFRTITWSYYRNSVGALLLYDITRRSSFEHLVEWLFEARRHIEPGRAVFEVVACKVDLESTRVVSTEEGKAFADSYGLSFIETSAKTGFNLEKTFVNLSQEIYDKVQCGELKVQDGWDGIKKGFSRSENTVHLLEAEAERDRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W2F6</accession>
    <name>A0AAV6W2F6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W2F6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="98" mass="11223" checksum="31A22B9B6A63B35A" modified="2024-11-27" version="1">MPSPIDYEQIAQAQKNDPELQSLLSNSNIFHFKKINLPDCEKAIFCDLSTGTARPYIPKQFREHVFANATQRVSLRGSKHLETRQDAVCVAVDRKRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W2V6</accession>
    <name>A0AAV6W2V6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell division cycle protein 123 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W2V6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39776" checksum="D78F83B2B6559971" modified="2024-11-27" version="1">MKVEDVRKCSFEKWYNAFTKVTIKSIILPLPDGFTSYILKDGIFLPKSSKEQCIAKRNSSDSEEEEVWEDSEEADVSEVPHFADFDKSIQDAIKTLGGKVFPKLNWSSPQDASWISFNNSCCCESVSDVYLLLKSSDFIVHDLTQRFLKCEDFVTDEESNKLMPDQEVEKFYLILRKWREIDTSGEFRCFIVNNTLIGISQREPSAYFEHIGRYKSDIVEDIVSFYQTHIHLKFPATNYVFDVYRRIKGRVCLIDFNPFGSVTDSLLFSWDELNSDSIKVDENRLPEFRFVDDNHGVQPRSLSYHAVPRDIVDISTGEDSFKLVDLLKMKIDEQKSSEDDENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W4A4</accession>
    <name>A0AAV6W4A4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W4A4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="171" mass="19830" checksum="D766A1D2D2D6EC61" modified="2024-11-27" version="1">MEPISLFPLPDLRSWHVIHHQILLASSPISEYQERCQHANHSEGGRTQKRPQKTITCGFPQTRVRHPHEGKILQRISSKRFFIKRTDEKQQLVPILSPNKFQKKRSEHHLGIMRRCKKTVPVQRLSLFGTMYKLPFCHTVSGGQTLLDIGIRRSTGYYESLVGSEKGKFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TD00</accession>
    <name>A0AAV6TD00_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006710">
        <property type="protein sequence ID" value="KAG8155755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TD00"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="146" mass="16220" checksum="864C8AA81387F1F6" modified="2024-11-27" version="1">MSLWSGRGNASAKKEGRGRPWETDQIQNLISLGEKKRAPKKGPKKGERGKGMHWAGFGIGWGQVPNFPCLGVQPRLHSTGERERWAPRRAAVQAKVNISLSDDEEDEISHGSDRTRILPREKKTITKTPKTQKKTTTSMGLSSPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TD82</accession>
    <name>A0AAV6TD82_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007507">
        <property type="protein sequence ID" value="KAG8155657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TD82"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19430" checksum="F4B626177E4EFE90" modified="2024-11-27" version="1">MRATFLILSLFFGRRTDRGNRPSVQHRGRAVRRRQDTELPTGESNCKLSLEMVTNDLNEKNQLSSVNRDEPPSAEGVKRGGALYPWIGIRSGRRRMCGKHLISAQVTPGNHQPPYRGGSCPPRGVSHTAASTTTPHRESHPGAPHSRQKGSSTLFLKWAYKGNPSFFIKFVPQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDH1</accession>
    <name>A0AAV6TDH1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006565">
        <property type="protein sequence ID" value="KAG8155823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDH1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="126" mass="14457" checksum="9D4D1F21F0E50681" modified="2024-11-27" version="1">MFLRFRKKPFHHRGTPTIKGPLYLILPQKYCHKIKYETSHSRQTVLDSPRPALHIAAGEETTRVEKDDKRVELATRTAFNSHPPAARCYDHNMHHIPTEIISAMERHGTGAGPLAEKLRREGSRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TF61</accession>
    <name>A0AAV6TF61_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG8161377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="21"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8161377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="10182" checksum="242CB85ADBDDB8F0" modified="2024-11-27" version="1">MGQVGPEGWRNPFRSETSAENANTCRVFSLADRKGNGVNIPQPDTEIGPSGPSAVNATDSETSDGGPGKSYLLFVRVRCPWNRLVRENRDACSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="35"/>
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            <end position="81"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8171120.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48036" checksum="F3DD6DA582341249" modified="2024-11-27" version="1">MGKQALTSHAVGKKHLDKDKYRQSTASVAVLFSSQRKSDGVSSTLAETASTTYTTPAEAASTTSSATDSSSISVPVPSTPIEGTSVGKNKPTERTYFVRDEVTKTEVLLCLLAVHRHQSVWDVSSLVDLLPLLFPDSEIASGVKLHKTKVSYGITYGLAPYFKEQLRETLLQCDMFAVGFDESLNKVSQNQQMDLVVRFWHPDKNEVCTRYLTSVFLGKSAVTDILIAFQNGLTGFDLKKMVQVSMDGPNVNKAFYSNLSSSLAENCEPDGPKLINFGTCGLHTVHLAFKTGCKNMQWEIVSFLRALYNLFQNVPSRRADFTKLTNSNIFPQKFFAIRWVENAKVAKRAIKILPAVQLYVKEIEQLKKNLKCHPKPKTTINVPQCNSYETVKDCVDDKLIICKLVFFQSMASFVEPFLTVSGEQASFSVFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG8171317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="9593" checksum="9C4EAD26671027A0" modified="2024-11-27" version="1">MEDENTTASVGDWCQVTYDDKLYPGEIKAKAEYLVSVMVPAGSYWKWPSKKDEILYPEECIIKRLDPPTVVNARGHFQFHNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIC9</accession>
    <name>A0AAV6TIC9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_003315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Arthropoda</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
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            <taxon>Araneoidea</taxon>
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            <taxon>Oedothorax</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003918">
        <property type="protein sequence ID" value="KAG8171475.1"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
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            <begin position="1037"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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        </location>
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        </location>
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        <location>
            <begin position="1875"/>
            <end position="1886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8171475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1913" mass="210006" checksum="5EBAF1248487FB17" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJR2</accession>
    <name>A0AAV6TJR2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011142</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
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            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003305">
        <property type="protein sequence ID" value="KAG8171982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJR2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="10994" checksum="F3CBBAFD92BC0031" modified="2024-11-27" version="1">MFDSFAARTPDLTIDLHVRTLRTSTRVSSGLVLSRACFHHLFGVPTVWPQTPPLPQVENAAGLRCARREGTGSECGRPPPALYFHFAAGLIQDPFTRATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKJ2</accession>
    <name>A0AAV6TKJ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003281">
        <property type="protein sequence ID" value="KAG8172006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKJ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="106" mass="11487" checksum="2CFD9D7E0EE19F54" modified="2024-11-27" version="1">MSIKLIPEPSSHNLELSKSFPAAGLDSHFVSSPVPSASAFGLNYVPSGYIDIKQNVQPSLSSSCPAPSRLQQPMQLGQQFLEARYGIFLSFESFLNIENKICGGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPS6</accession>
    <name>A0AAV6TPS6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Putative hydroxypyruvate isomerase</fullName>
            <ecNumber evidence="4 7">5.3.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_010540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate</text>
            <dbReference type="Rhea" id="RHEA:11952"/>
            <dbReference type="ChEBI" id="CHEBI:17180"/>
            <dbReference type="ChEBI" id="CHEBI:57978"/>
            <dbReference type="EC" id="5.3.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the hyi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="JAFNEN010001564">
        <property type="protein sequence ID" value="KAG8173654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPS6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008903">
        <property type="term" value="F:hydroxypyruvate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046487">
        <property type="term" value="P:glyoxylate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050417">
        <property type="entry name" value="Sugar_Epim/Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43489:SF6">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43489">
        <property type="entry name" value="ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="9">
        <location>
            <begin position="20"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8173654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="260" mass="29829" checksum="F8706B320893E08D" modified="2024-11-27" version="1">MRFAANVSMMFQNIRMLDRFQEAKRLGFSAIEAQWLYDFLIKDLREAREAADIPIVLINSPKCFEVFEPNSVGMACIPDQELNFLHSINLAVDYCKSLKCSKLHIMAGNLSDNSTFEECEQKYIKNLKTVSELLKLHNITGVIEPICKQVLPNYFMNSYENAVKYIKEVNSENIKLLLDVFHLHNIEGNVEEGVLKYLPYAGHIQVSQAPKRNEPFAEGPINYKNVFDILKTCGYTGEIGLEYIPTGPVPDFEWIKECKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQE1</accession>
    <name>A0AAV6TQE1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_014699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001570">
        <property type="protein sequence ID" value="KAG8173645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQE1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000300">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058999">
        <property type="entry name" value="EIF3CL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26569">
        <property type="entry name" value="EIF3CL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="280"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="487"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8173645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="533" mass="61879" checksum="8E336D84A1BE0E0D" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQK7</accession>
    <name>A0AAV6TQK7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001413">
        <property type="protein sequence ID" value="KAG8173939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQK7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043383759" evidence="2">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8173939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="139" mass="15484" checksum="4C6528E526D38597" modified="2024-11-27" version="1">MKLITAIFVVATLVLIKQCQSTKEKTSGFYCPKSGETNLMATTVSYSKINNKHLPQTADEDQSYMTDSSQTSGDAYEKAENSNRVRRSQPTNTFGLLNILMNPRRYILSQVSTVEPSATTPVLEVKSKMEDNSTLMSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQZ6</accession>
    <name>A0AAV6TQZ6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001419">
        <property type="protein sequence ID" value="KAG8173927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQZ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043428652" evidence="1">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="208" mass="22622" checksum="7DE2839766746D9F" modified="2024-11-27" version="1">MASSQTMLIAAVAAVLVASVAADDDGGCRDAGGDPTSVESFSASYYTANVVLHEESMLNITLGGGEAGMKLFKVVKQCLEDHQQCNADSVAYTFGQALARARSVSLQGYFKNIALTVGRSLFKFGILNCSNSVALSLEFLHFGFVEFNKYPKDLYNFENYMHNSVYSLVDLVLAHGISLEDTAQDIADTFYETYRDEQPDCKLGKSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRD3</accession>
    <name>A0AAV6TRD3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001326">
        <property type="protein sequence ID" value="KAG8174092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRD3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12843" checksum="30BFAB87FDDCE673" modified="2024-11-27" version="1">MQNRLLREPDLSLDRAVEFVRTSEISKRQIASMNAGPFVNTVAPDLHRGRGSGGSRLFRCQACGRIHQQRGCPAQGKPCFRCGDMGHFSNNVPGKATTDSPIFGGPGDRRHAPTDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRL3</accession>
    <name>A0AAV6TRL3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001198">
        <property type="protein sequence ID" value="KAG8174502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRL3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="136" mass="15637" checksum="BC0F7AA31F5031DD" modified="2024-11-27" version="1">MSAVVPTAGKTNNILLKYSAILLNTAILVFHVYDSAYLLYGLKLKSFGITFMLANSITFMHRYFLGRRFYSLKRIANIMSNFDIQENNRSKLVILIWIVLSTLLIRYSCWGLTCTTVEATLTLEVYLSQTRRQPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TS33</accession>
    <name>A0AAV6TS33_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_011415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001240">
        <property type="protein sequence ID" value="KAG8174363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TS33"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000104">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF14">
        <property type="entry name" value="CELL ADHESION MOLECULE DSCAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043798332" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="115"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8174363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="218" mass="23481" checksum="BDBF9A9318C4A665" modified="2024-11-27" version="1">MVILLFTFVVLQVRSTIAQDAPVIQPFNFPEFSTTGQTAIVTCAVSKGTRPLQFSWLKDGKDIENIPNASVHNGPGFSVLTVGPASKENVGNFTCVARNMHGQNSYTSQFILNEPPVWVNEPQDVRVIENDFLELICTASGHPLPKISWSKVTGDNSGPSTNIGSTSNAQIFSNGSLIINSIKHEDDGTYTCTVSNDIGTALQKTIAIVVSGKNKKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSC3</accession>
    <name>A0AAV6TSC3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001203">
        <property type="protein sequence ID" value="KAG8174483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSC3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7797" checksum="0AE5A37B40E10B9B" modified="2024-11-27" version="1" fragment="single">TMELKKTKDESKGKDKVKRELRIVMCVNSELLELAGDLKVPKFAEVTVEAKCQGFAESLFANEGICYQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTP6</accession>
    <name>A0AAV6TTP6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001044">
        <property type="protein sequence ID" value="KAG8175255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTP6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="439" mass="50287" checksum="1EA55FFBD82B9360" modified="2024-11-27" version="1">MSTRWKTFDKKKAPMKIVPVIQEVFSKINVDACGPLPVTPSGKRYLLTAMCLSSKYPDAVPVEDITSVTVVDALLQIFSRMVFPKVLQLDQGSSFTSALSTTFLEKFGIKVVHSSVYHPQSNPIERFHRTVKRVLKVLCLESGSDWEQAIYPALFALRTVTHESTGFTPAELVHGKNLRMPLTLLYEKWLDVEETEGEPVTEYVFSLINRMKRCQELAISKMEECQQKNKTWYDKRAVKREFRIGDLVLIFATFKSNKLSPHWTGPGKILRKLSETNYVVQLPGEKATSKVYHVNMLKPYYKRPEEINYLISDLEGENDEEQMEIPWLAGYYSRYIPMFSSIAAPLTDSLKGKARKGPITWTKECEEAFDKLKNCLCNYPVLYSPDYQKPFIVETDASDQGMGVVLSQLADNETEEHPIIYLSKKFTSVEKRYSVKVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTY2</accession>
    <name>A0AAV6TTY2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_020199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001115">
        <property type="protein sequence ID" value="KAG8174920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTY2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8174920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="172" mass="19307" checksum="2D62AEA66696F50B" modified="2024-11-27" version="1">MASEKCVVCSLEVKAESDSIQCTGLCKGVFHFYCAGFSEKSFRITEQRRLHWRCLKCQPAKAQTNKPSSLKASTEDNMIVHTEENLSPTTVVVQKSLVVETESSSNNPCNSGVPNTPETQSPFVNNFVTIPENQSDLKQFIAEQFKEFAKNLEFHNNIVSDLTKSINQLNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUC6</accession>
    <name>A0AAV6TUC6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_006639</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001038">
        <property type="protein sequence ID" value="KAG8175279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUC6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF8">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8175279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="502" mass="58879" checksum="981DC4EF9CF6B041" modified="2024-11-27" version="1">MFISTKTRTLRSDILKDVDTKLFKAIDRLIMDLELKQRKPPPNGLNGVKDGSNQLHKKSELPKELPPKEFILRNSTLTNLWENAHLRSVYNICLSLFVLLYLNITLFYCLNFQKLKEDLAVVAWTFGQFHIVTALWFGINLSIVFMLYPTFRFWATTRSFVKKQSLYDSIFCTLFVIYQLALLLIPARVIVTFNLPPVSSFTVLAEQSRLIMKTHAFVRENAARALRYKPHQDGDKEDSKPCPEVGKLMYFLFAPTLVYRDNYPRTPYIRWSYVAWNFLQVLCCIVGAYIPCTYFIVDTFNRVGIEPIPMVSFVATLAGSIFAGGILMFLVFYGMFHCWLNAFAEMLQFGDRMFYDDWWNCTSFAKYYRSWNMVVYDWLYSYIYRDMYTLLGRNRTGAMLVVFFISAVIHEYILAICFKFVFPLLFILFSTFGVILVFITRRQTSSFWNVFLWGSMFQGWGLLTVFYSMEWYARINCPRTLHSWLDYVVPRSVLCDVISLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUF9</accession>
    <name>A0AAV6TUF9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000979">
        <property type="protein sequence ID" value="KAG8175627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUF9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="215" mass="24109" checksum="21C32AAF986C7E26" modified="2024-11-27" version="1">MDISDLLKDWEFGELAQQFIENGINMEESESTSDSTLGSGAEFSSSSEANMNNHLPKRIKRSESGSNEEREPDVTPQKKPLFYPPPTSNDAHQKTNFEDLHCELNEHFEFMNKRQGKTEQSSDRSSTQGKQKKLLDFPGYFSIKKDPTTPCKSVSFSCATPTGQIYNIKQKSSTTKNKQTSSKSQQPPMDNSNFTVGNKSSSTFAEDSEKILLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXZ5</accession>
    <name>A0AAV6TXZ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000865">
        <property type="protein sequence ID" value="KAG8176568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXZ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="81"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="195" mass="22422" checksum="3E29C4DDFAD1EF1F" modified="2024-11-27" version="1">MPRVKKQGKHLYNIRKMPKRVDVPEIAEPSKNKNVVMNERLLNLSNVSEEDKIIQVSSKSKFVLIDIDMVNTLLLSAAFPECQQSQLKLNCKNNYGFAHKMELFCLNCNACINSSCSSKRLENTKGFEVNKFVTEAFLYFGKGYAAVEQFGMLLGMDVMSDKTFSEYTRIVFKDLEETTRKVLEDTRNRVKKPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TY07</accession>
    <name>A0AAV6TY07_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_006955</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; sulfate assimilation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000829">
        <property type="protein sequence ID" value="KAG8177012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TY07"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050428">
        <property type="term" value="P:3'-phosphoadenosine 5'-phosphosulfate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000001">
        <property type="entry name" value="bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000006">
        <property type="entry name" value="bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="41"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="223"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="386"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8177012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="616" mass="69635" checksum="457508D396AA22FF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZK1</accession>
    <name>A0AAV6TZK1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000803">
        <property type="protein sequence ID" value="KAG8177209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZK1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29744" checksum="CA711285A05E57AF" modified="2024-11-27" version="1">MLHSFISWYRCLWRYPNVLSSDNVGFVRRPSAQDCDIAHFYECVAQVTDFADGYSFQISSAEQLKESCKTKTKAVDCVKDFISKCMKREDREVFDLTAGGKSTLVQELCIEGSDINTGYLKHLDCWERISNDTQYCNDMFEKSQHMLMQDDVIERLRVFHACCNFEWHKQCKYKAAETQCLDDAKEYIEQVSTLLGGRILRTLCGTQGTYSNCYNQLYGVEAEDLDERYSKYSDVSSALGIGMRSDFDVVVVLALSLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1K4</accession>
    <name>A0AAV6U1K4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000757">
        <property type="protein sequence ID" value="KAG8177722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1K4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043349970" evidence="1">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9315" checksum="05F1AD02FE88F248" modified="2024-11-27" version="1">MKLVILLLVLPCFVRASKEQCSNVENAAPTRTAVRLKMVFAVKKKAAVNRVTSAVVAAAVQHPIGAVKIKRFAVLMEESAAVNTVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2V2</accession>
    <name>A0AAV6U2V2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Engrailed</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000703">
        <property type="protein sequence ID" value="KAG8178313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2V2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7743" checksum="2CB53360939BEA07" modified="2024-11-27" version="1">MDGDTTLFPINPKVEIHQESNRILPPQRDSDSEPDPRSIRAEVLYPPSHVSNPICSSPHPAAGSNRQVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3E5</accession>
    <name>A0AAV6U3E5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_002808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000721">
        <property type="protein sequence ID" value="KAG8178046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3E5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001329">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8178046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="209" mass="23225" checksum="0828DCF83BDAEE38" modified="2024-11-27" version="1">MATTKIPEQKVILCGEFGVGKSSLFRRFAMNTFVSSSDRHSTLGLDHFDKVFQMHGRNVRLQLWDTGGMERVASITSSYYKFAEAAILVFSLDSPDSFNILSQHLLDIVTYAESAKIFLCGNKTDLLSSTSSEDGPITDADIENFCEQCHNLVSGVYKTSCKTGEGVDEMFTDIAKQLVGNCRVKDVEQEIKDSFKVTERDEPNQSCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4W2</accession>
    <name>A0AAV6U4W2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_016132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000619">
        <property type="protein sequence ID" value="KAG8179562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4W2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18983">
        <property type="entry name" value="CBD_MSL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000024">
        <property type="entry name" value="Mortality factor 4-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF48">
        <property type="entry name" value="MORTALITY FACTOR 4 LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="7">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8179562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="366" mass="42146" checksum="3F5B647257F34909" modified="2024-11-27" version="1">MAPPPPEEVEEQEIINHKFKDGEKVLCFHGPLLYEAKCLKAQVKDKTTKYYIHYSGWNKNWDEWVPESRVLKYNEVNMQKRRDLEVINSKERKKSGKGGAKKDPKDRESSVLPPQEKTPKQKNKDAEASAASTSNETPTEPPKKKRMLKAEQNVETEEEYIQKIEIKIKIADELKHRIVEDWNCINREGKLASLPARIPVETLISDYVKQRTSVKGMTPNKESAIVEIMNGVKEYFNVMLGPQLLYDLELPQYNKLISEYPDSTPCQLYGVSYLLRLFTMLGGILVYTPLNEDSIHLISTNITDLQKYIAKWASTFFSNSDYIDGPEKKSIKKEIKDTKIKADYIDGPEKKSIKKEIKDTKIKAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5C9</accession>
    <name>A0AAV6U5C9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_023617</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000645">
        <property type="protein sequence ID" value="KAG8179155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5C9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047157">
        <property type="entry name" value="PHRF1/Atg35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="837"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="914"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="970"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="982"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8179155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1154" mass="130272" checksum="0873EDBBDB106BF4" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5U4</accession>
    <name>A0AAV6U5U4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_017801</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000609">
        <property type="protein sequence ID" value="KAG8179662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5U4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="7">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="6">
        <location>
            <begin position="174"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8179662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="379" mass="43552" checksum="35153CFCDAA808F4" modified="2024-11-27" version="1">MNAHKSQGCSPLTYKMSSKPVGLCLIINNINFSKSRTRDESKFDVSALRSLFEFLGFKVTVEQDLTAQEMTNCLEKLSKTPELGRVDSIIVYILTHGDRDKYNVDKLRGIDEEEVALTNVYEMFNHNNCEMLLGKPKLFFFQACRGKEEDLGCFKRLADTDATSFQTSDRSSFTLVHFPSLADTIVVHSTMPCHLSIIDKHQGSWLCQELIHVFTTDHSRHDLFTMLNTVSKRMENRTSGDKCKQTVHIEQFGVSGIVKFGLDKCKCQDIFEQVSIQDIFESSLFSKGLQSSLFSKVQSSLFFQSIAEQYFSQRIAEQYIFQKIAMQDFLQWSEQSFFQSIAEQYLSQRIADQSSFQRIAKQHFSQRIAEQSFFQRIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5W9</accession>
    <name>A0AAV6U5W9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000651">
        <property type="protein sequence ID" value="KAG8179051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5W9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="141" mass="15981" checksum="7E1589B7741E04B3" modified="2024-11-27" version="1">MTEQYGRNSDGSYQFLQVPGERHPRYARKLDPSTNQKVEFYPPDQGCIYMGDEPSRDDKPYWLQTEPPLSAHLYTLSRHVSTDFVTDVPCSSRPVRIPRFSRVPNYVKGTLYPGKGGTSNLTTTILLLIVLVTCLVVVVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6S7</accession>
    <name>A0AAV6U6S7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_011598</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000636">
        <property type="protein sequence ID" value="KAG8179334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6S7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18500">
        <property type="entry name" value="BACK_IBtk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="10" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="12">
        <location>
            <begin position="142"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="12">
        <location>
            <begin position="196"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="12">
        <location>
            <begin position="247"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="560"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="703"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8179334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1181" mass="133873" checksum="5CDFC38A5C886A6C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6U8</accession>
    <name>A0AAV6U6U8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_025081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000605">
        <property type="protein sequence ID" value="KAG8179749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6U8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040394">
        <property type="entry name" value="FBX25/32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123">
        <property type="entry name" value="LD30288P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123:SF7">
        <property type="entry name" value="LD30288P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="218"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8179749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="372" mass="43936" checksum="31AB0CC5734E198C" modified="2024-11-27" version="1">MPFLGKDWRSPGEAWVKTNEGWERKKILEYKSHGQPRYSRNRNVFHEKKRDTSNYEDPEFPYANSNLAYINNQVINECQPHCQITLKNTKEVIGFNNIGEAIQKLDFRNAVHDIRRFNYICKLLHLLITENLTTLSGRATAVLFAVLEEVAQQVASNQQNLHILHMLLNDLRRIIRKYYCWGRPLGSTLLWEQHLRTIDRICQFASDIQIKEPIEDGTHRLTDMPAAILREILLRLSDYKDLVNSAQACDDMKFVMDEQHIWRELCKFHFTREEIKVFFEEWKVKPVHAKIDWQVAFHQLRRKHGLKEEYTESLFLCRHCRCLFWKSFGHPCVDPSRSIDMDCMEDPNGTLVNTVPLYIPVPPQAFLSFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6X8</accession>
    <name>A0AAV6U6X8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000568">
        <property type="protein sequence ID" value="KAG8180312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6X8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="66" mass="8108" checksum="CB599415CD43C9B6" modified="2024-11-27" version="1">MIVQISPINWRLCEKLCNDMDRDHYQLLLHCEVRWLSKCNFNFNQNSFKQNQHIFTFVLKTRKSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U713</accession>
    <name>A0AAV6U713_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED19</name>
        <name evidence="8" type="ORF">JTE90_016358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000593">
        <property type="protein sequence ID" value="KAG8179985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U713"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019403">
        <property type="entry name" value="Mediator_Med19_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536">
        <property type="entry name" value="LUNG CANCER METASTASIS-RELATED LCMR1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10278">
        <property type="entry name" value="Med19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8179985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="294" mass="32843" checksum="3BD15D8B267BE69C" modified="2024-11-27" version="1">MISTKPNLFASCHRKLPYCTMLGDEEIRFSAEWCRSEVSRANLHLLLQKMADVGRRPESYSPKSSPRGSRSPVVPRQDSTGTLKTTISLGKTPAIVHSGPFYLMKEPPKSELTGATNLMTFYNLEHAYNKFCGRKMKDQLSAFLPNLPGNIDGPGSHDNSSLKSLIDKPPIGGKELLPLTGSQLSGFRLHPGPLPEQYRLMSQQPQKKKHNKHKKHKHKAGDTPTQESTQDVSIEGPHEKKHKKQRRHDEDKEKKKKKKEKKKKKKHGPDVVSGTSLPGPPSAMPHPSVVPKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U740</accession>
    <name>A0AAV6U740_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Caspase family p20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_017802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000609">
        <property type="protein sequence ID" value="KAG8179663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U740"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8179663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="130" mass="14959" checksum="B55484C0A3A7CB16" modified="2024-11-27" version="1">MTNCLEELSKNPELGRVDSIIVYILTHGDRHEVHNVDILRGIDEKEVVLKNVYKVFNHENCEMLLEKPKMFFFQACRGKKKDLGRFVRLGLDNTDITSFKTDDSTACISSCSVHNRHNCCSFYNAMSLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7G5</accession>
    <name>A0AAV6U7G5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_007957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000592">
        <property type="protein sequence ID" value="KAG8179989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7G5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="252"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="384"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8179989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="689" mass="80693" checksum="C94B9DE8635E9802" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9A2</accession>
    <name>A0AAV6U9A2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000557">
        <property type="protein sequence ID" value="KAG8180664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9A2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="318" mass="36455" checksum="A70FDB4B70B262CA" modified="2024-11-27" version="1">MAPLTAAERQRKRREKLKKDGQYEEYKKKHSLLMKKHRQVKADKVSKLPVAVQKELKELEKKKVRERVAKCRRNKSVKQPAENKSSPCKIYKSTSALGKAVARARRALPNSPRHKEIVVRKLFSSECNIDLTTSFNSSKSTSNHANAINSDTKIKIEEFYERDDISRMAPGRKDVVTIWERGAKIKQQARHLICTINEIYIMFKIENPSAVVGKSKFFELRPKHILLSSKLPHNVCLCIYHENFINAVNVLHQHNDAVPNYSYAFPEEIICVPASRNCWMNECQDSGAGVTDKNAKKTDSDNASAENYNVNNRDLFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9K9</accession>
    <name>A0AAV6U9K9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore complex protein Nup98-Nup96</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_012136</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000585">
        <property type="protein sequence ID" value="KAG8180121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21240">
        <property type="entry name" value="Nup98_GLEBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="13">
        <location>
            <begin position="798"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="654"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="654"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8180121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1854" mass="201331" checksum="D5B471071CA648FF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9Q1</accession>
    <name>A0AAV6U9Q1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_005930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000547">
        <property type="protein sequence ID" value="KAG8180844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9Q1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.70:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme atg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="337"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8180844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="667" mass="74065" checksum="C09D56349D8FF261" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAA2</accession>
    <name>A0AAV6UAA2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">DNA oxidative demethylase ALKBH2</fullName>
            <ecNumber evidence="23">1.14.11.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Alkylated DNA repair protein alkB homolog 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">JTE90_014779</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + 2-oxoglutarate + O2 + H2O = a 2'-deoxyguanosine in double-stranded DNA + glyoxal + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:70487"/>
            <dbReference type="Rhea" id="RHEA-COMP:17910"/>
            <dbReference type="Rhea" id="RHEA-COMP:17912"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:34779"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:189586"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:70488"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + 2-oxoglutarate + O2 + H2O = a 2'-deoxyadenosine in double-stranded DNA + glyoxal + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:70463"/>
            <dbReference type="Rhea" id="RHEA-COMP:17897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17903"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:34779"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:189583"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:70464"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + 2-oxoglutarate + O2 + H2O = a 2'-deoxyadenosine in single-stranded DNA + glyoxal + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:70459"/>
            <dbReference type="Rhea" id="RHEA-COMP:17896"/>
            <dbReference type="Rhea" id="RHEA-COMP:17904"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:34779"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:189583"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:70460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + 2-oxoglutarate + O2 + H2O = a 2'-deoxycytidine in double-stranded DNA + glyoxal + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:70467"/>
            <dbReference type="Rhea" id="RHEA-COMP:17070"/>
            <dbReference type="Rhea" id="RHEA-COMP:17905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:34779"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:189585"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:70468"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + 2-oxoglutarate + O2 + H2O = a 2'-deoxycytidine in single-stranded DNA + glyoxal + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:70471"/>
            <dbReference type="Rhea" id="RHEA-COMP:12846"/>
            <dbReference type="Rhea" id="RHEA-COMP:17906"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:34779"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:189585"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:70472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:30299"/>
            <dbReference type="Rhea" id="RHEA-COMP:12192"/>
            <dbReference type="Rhea" id="RHEA-COMP:12193"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:32875"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="1.14.11.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:30300"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + 2-oxoglutarate + O2 = a 2'-deoxyadenosine in double-stranded DNA + formaldehyde + succinate + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70443"/>
            <dbReference type="Rhea" id="RHEA-COMP:14236"/>
            <dbReference type="Rhea" id="RHEA-COMP:17897"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:139096"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:70444"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + 2-oxoglutarate + O2 = a 2'-deoxyadenosine in single-stranded DNA + formaldehyde + succinate + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70447"/>
            <dbReference type="Rhea" id="RHEA-COMP:17895"/>
            <dbReference type="Rhea" id="RHEA-COMP:17896"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:139096"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:70448"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + 2-oxoglutarate + O2 = a 2'-deoxycytidine in double-stranded DNA + formaldehyde + succinate + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70439"/>
            <dbReference type="Rhea" id="RHEA-COMP:14237"/>
            <dbReference type="Rhea" id="RHEA-COMP:17070"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:139075"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70440"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + 2-oxoglutarate + O2 = a 2'-deoxycytidine in single-stranded DNA + formaldehyde + succinate + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70435"/>
            <dbReference type="Rhea" id="RHEA-COMP:12846"/>
            <dbReference type="Rhea" id="RHEA-COMP:17894"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:139075"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:70436"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with PCNA homotrimer; this interaction is enhanced during the S-phase of the cell cycle. Interacts with nucleolar proteins NCL, UBTF and NPM1. Interacts with XRCC5-XRCC6 heterodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.33" evidence="23"/>
    <dbReference type="EMBL" id="JAFNEN010000537">
        <property type="protein sequence ID" value="KAG8181067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAA2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000004">
        <property type="entry name" value="DNA oxidative demethylase ALKBH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF1">
        <property type="entry name" value="DNA OXIDATIVE DEMETHYLASE ALKBH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="28">
        <location>
            <begin position="159"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00052800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00053025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00062909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00066725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00072134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00077989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00081727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAG8181067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="269" mass="31275" checksum="6F6763CC16DAF818" modified="2024-11-27" version="1">MQKSMDDKKRKSECVSDEDELATNAYYNEEYTIDELRDKRSQIGAYRNKKLAFTVINDNIDWTLIQRPDLNLKYGKIPDKHAADAILKQLEEEIQYFDGELTRVKVFGKWHNIPRKQVVFGEEGLSYTFSGISLPAKPWDACPVVKGLQNYVELVTGECFNFVLINRYKDGNDHMGEHRDNEKELNPDSPIVSLSFGEERPFVFKHKDSRGKNSKLDIAPLKIQLEPGSILVMEKPTNEFWYHSLPVRKNIKGVRVNLTFRQMIHVKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UB19</accession>
    <name>A0AAV6UB19_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-latrotoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_018891</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Homotetramer in membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cationic peptide 01 (latrotoxin) family. 03 (alpha-latrotoxin) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000516">
        <property type="protein sequence ID" value="KAG8181424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UB19"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="12" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8181424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="264" mass="29713" checksum="E61AE570F630A269" modified="2024-11-27" version="1">MDFSGLIASYRPPSAVEEDVLETLHKDQRSRQPLRRLADHIIRGMPSDCIREFIEEEKLMDCLDGPIHKGLRLIHYAVYQNEEDTVVLLLEYGASPNVMDEMGFSPVHLCAEKGYSRLIDILVSYGARIRFTEVNPEDQSFGVPPRACAADEPLRLAIRNCEHATAQLLLEHGANPSALYYLGEEINLVNPVDYRSVWKMEAFKYIEKLGVDLGIELCHEMAALRNVELGGFWDRSSVLTVSMLVVVCSRSCVVEESSTKIALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBQ4</accession>
    <name>A0AAV6UBQ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_006249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000555">
        <property type="protein sequence ID" value="KAG8180691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBQ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051325">
        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8180691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="309" mass="35521" checksum="3BB1059192767BC0" modified="2024-11-27" version="1">MVVIPFTVPGQKLLIDMNDMMIIDNFRLSAGAVLINEEQQTVCLIRDNTSGEYLLPKGGKKTFETLSNAAQREVFEETGYENEVASEHLLGIQFRPNISGKPGEHKVVYWYYSKLTSNVFHDGTQDEGEDFNSEWLLVEDAIDKLNFEEDKILVRRGFQTLLGTPLASHEADLQRWNSENQCIRMLTRPSTSIERGFLVTDVGRNKIILIRDCDTDSWKLPSESCIDSNMNLCGKPKDECAPFLFELKLDDEDVTVKQWYHLEVSYYDRIRERSVIAKDMLLIDKDDALKKLKNNLHEMNIVVSAFKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBZ7</accession>
    <name>A0AAV6UBZ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sec1 family domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000509">
        <property type="protein sequence ID" value="KAG8181529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBZ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="73718" checksum="729D75AE21931868" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCD1</accession>
    <name>A0AAV6UCD1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein FAM91A1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_018745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000511">
        <property type="protein sequence ID" value="KAG8181508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCD1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028097">
        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="3">
        <location>
            <begin position="368"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8181508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="92956" checksum="B3451D74A6CFA0DA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFJ5</accession>
    <name>A0AAV6UFJ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_003335</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000439">
        <property type="protein sequence ID" value="KAG8182957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFJ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="15">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="377"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="570"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8182957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="757" mass="84311" checksum="D1AF5557FA797489" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UG82</accession>
    <name>A0AAV6UG82_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000434">
        <property type="protein sequence ID" value="KAG8183044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UG82"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="71044" checksum="38C2F1C27B2F3D51" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGT1</accession>
    <name>A0AAV6UGT1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein transport protein Sec24C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_028053</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000410">
        <property type="protein sequence ID" value="KAG8183690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGT1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000020">
        <property type="entry name" value="protein transport protein Sec24D isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="9">
        <location>
            <begin position="513"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="10">
        <location>
            <begin position="590"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="12">
        <location>
            <begin position="839"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="11">
        <location>
            <begin position="935"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="8">
        <location>
            <begin position="1055"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8183690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1184" mass="130604" checksum="05B13C59B629A390" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGW2</accession>
    <name>A0AAV6UGW2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_015669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000435">
        <property type="protein sequence ID" value="KAG8183038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGW2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8183038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="402" mass="45101" checksum="5C7C8C82FC066FF8" modified="2024-11-27" version="1">MSGNGQDHQLPDAPEPVDDGQEEDDDDFGEFEGFEGGVERMQAQPAPSPWATFPDLLPVQSSPATPAEENQAAASSSRNQNLPGNSREMWQPQLPPNNGANHEEPRPMPQQMRTLNPPDVSLGTNQAVGGRVTPDNVHDAALAVVMDHLDNNIDARLPVAQLERLREQLDAAEQGRAVLEEQVVGLRQRNVELEQQVVSSQVQINDLHTRLQRNQEALEQRLSEMRQFNTADWRQDLRQIQEEIVAIKQTQLAERSELEASRQNLEEMRTGICNRLQVLESNIQREYIAMEHRLSKQFDEQCHQVKAAIETVVQQTAQQVTGNLSQLVCEAVQNSNCGDSQGNLLQSIKVELEKHKDQQKRVLEEERQRQLITVSSALQSALQHLNSAINNDSKVKDGNNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI53</accession>
    <name>A0AAV6UI53_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hermansky-Pudlak syndrome 5 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_002402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000406">
        <property type="protein sequence ID" value="KAG8183764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048066">
        <property type="term" value="P:developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056499">
        <property type="entry name" value="Beta-prop_HPS5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056445">
        <property type="entry name" value="TPR_HPS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287:SF18">
        <property type="entry name" value="BLOC-2 COMPLEX MEMBER HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287">
        <property type="entry name" value="RUBY-EYE2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23756">
        <property type="entry name" value="Beta-prop_HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23758">
        <property type="entry name" value="TPR_HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPS5-like beta-propeller" evidence="2">
        <location>
            <begin position="15"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="HPS5 TPR" evidence="3">
        <location>
            <begin position="1087"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8183764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1508" mass="169625" checksum="F533D53418BE42EA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULD9</accession>
    <name>A0AAV6ULD9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_006773</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000375">
        <property type="protein sequence ID" value="KAG8184370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULD9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8184370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="176" mass="19989" checksum="C784E5ECD2A5D3B3" modified="2024-11-27" version="1">MTHQSSISICASDDCYPMTSTGLENPPIGNLVCDGDTVVTPKEPLLIDLVDEESNGSEGRLIIDLGDDGDMCGDPLNLASHSSPTTSGLLQTPYVCFFCEKLFKKKKKLSWHLKYHTCQTLHLCPVCEKKFRRKRSYTDHMHVHSNEKHFKCAVCGETFKQKVRLQKHKKMHRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULZ7</accession>
    <name>A0AAV6ULZ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_022368</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000335">
        <property type="protein sequence ID" value="KAG8185437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULZ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000086">
        <property type="entry name" value="transcription factor E4F1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8185437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="288" mass="32660" checksum="24195B12AF1BE39D" modified="2024-11-27" version="1">MEKISKSNSPARKSYACHICYRTFNRLPRLQLHIRTHNNPSILVSKSLEKTSEENNEKDESPISPTSAEENVEIDIENVEIDIVVKTEYSDDEIPSKDKQQKNSKQKNSKDKLKLPHDCKLCPMKFPSRCQLMRHQLAHTEAKPYICKVCGRAFATIGNLSVHSRVHSPSHKSRKHSKDNPDDPPPVTPSPRKKESYQCEHVMEDILRKVGDSADGPGTDATKTQLCNKSVNSIKPSQSSFGATKAKEVKKNEYSLLTTRANFRPRARKSIIIQSIYSLNTTRKQYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMT6</accession>
    <name>A0AAV6UMT6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000329">
        <property type="protein sequence ID" value="KAG8185614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMT6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="59" mass="6576" checksum="C54FCCB16DF2D2E8" modified="2024-11-27" version="1" fragment="single">VGLDLYEGTVRNNRKAGVLEPAISKIKSLKFATEAAITILRIDDMIKLAPEQKDPRHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ20</accession>
    <name>A0AAV6UQ20_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_007331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000306">
        <property type="protein sequence ID" value="KAG8186310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ20"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.650:FF:000001">
        <property type="entry name" value="S1 RNA-binding domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.310">
        <property type="entry name" value="Tex RuvX-like domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050437">
        <property type="entry name" value="Ribos_protein_bS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF10">
        <property type="entry name" value="S1 RNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="863"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8186310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="926" mass="104049" checksum="61CF10DCF81FAA87" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URK4</accession>
    <name>A0AAV6URK4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Buccalin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000308">
        <property type="protein sequence ID" value="KAG8186263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URK4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010276">
        <property type="entry name" value="Allatostatin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05953">
        <property type="entry name" value="Allatostatin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043820808" description="Buccalin" evidence="2">
        <location>
            <begin position="34"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8186263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="51976" checksum="2DA71609A553F3ED" modified="2024-11-27" version="1">MADRRSTPALSRVTSPTTTIYILVFLFLQLSCATKEIPTRSNNKIEDETPSIADSVSIEQSKRIPQAYSFGLGKKNVELSDIDSQEEDLENEIAVALEDESESGKVKRDGKLERFSFGLGKKRASDARFNFGVGKREAHRHEDSRFAFGLGKRGPEDRFAFGLGKRGPEDRFAFGLGKRGPKDRFAFGLGKRGPEDRFAFGLGKRGPEDRFAFGLGKRGPEDRFAFGLGKRGPEDRFAFGLGKRGVDNRFAFGLGKRGPEDRFAFGLGKRGPEDRFAFGLGKRGPEDRFAFGLGKRGPEERFAFGLGKRDLKDNRFSFGIGKRSIEDDNRFAFGLGKRGIEDNSRFAFGLGKRGLEDNSRFAFGLGKRDKDEDHFVYDLGKRDDGYNRFAFGVGKRGETERVSPQQDGNARFGFGLGKREGTQSTQGLDKRETFNDDIDEYIKRRFSFGIGKRSVDPVMEFATSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTF2</accession>
    <name>A0AAV6UTF2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000287">
        <property type="protein sequence ID" value="KAG8186836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTF2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="483" mass="54249" checksum="84EB8D9610C8B8FD" modified="2024-11-27" version="1">MKYVTLKKMTSESSAMCRVSDNEMSYFQRRAREMLLLRREDHAWKEFCKTCTACDCISCRGTAVLAEQTSAEPPKLVKNTSSATRTQSKTLQTLNEIKTKLGQIDLALSKKTLPLKNSYSPSQASAEIKLPRSLSQTETSKNPTNVKHIDLIEKCLKQSIQRLQSSAPRKVASPQPSIKSNRGFFLPRELQQQRTIARNAYLASLSKSKSSLQPSSLIIKEKTSNKELKKRIQEVKTRGKVPKPKVIHKTRPKITLQSKIKETAKEGSSSQPTVFEDRNIEAATDGIVDDLVGETVLLLNRIRQKKSGTSNTLSHQAQQVDKDVVLHIPSPSKPVNKENAKSGSLQNWTKIRQTPFNLKLPKEENTLPKTPHLSHQDNHPETSNQMPSQSQSTLAKTSIFSDPVRLTVDPETSSSIERNRRDYARHLDKVARARKGNFDPCTLANMISEFLLDECIESVSKELVDIPGSLITDLCDQEFFLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXR8</accession>
    <name>A0AAV6UXR8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000227">
        <property type="protein sequence ID" value="KAG8188924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXR8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8434" checksum="C1DAA7F3A0627D5D" modified="2024-11-27" version="1">MSRWSKVSRSSDGWNVEVQLGNQHIPIQREESATPPLFTYEATEFRHSPRQWSVSSALGAARFMPLVSDQGRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZR7</accession>
    <name>A0AAV6UZR7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_025501</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000222">
        <property type="protein sequence ID" value="KAG8189071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZR7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="103"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="564"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8189071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="770" mass="88767" checksum="04751AF0B5C00BF6" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZW7</accession>
    <name>A0AAV6UZW7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_000114</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000196">
        <property type="protein sequence ID" value="KAG8190017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZW7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14548">
        <property type="entry name" value="R3-PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000009">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041201">
        <property type="entry name" value="PTPRJ_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18861">
        <property type="entry name" value="PTP_tm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="13">
        <location>
            <begin position="184"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="14">
        <location>
            <begin position="356"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8190017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="472" mass="55075" checksum="D7E3620BB3B70C9C" modified="2024-11-27" version="1">MRAHLLHSNIHEKKTFLSLKYVKKISSYVDYLFFVILGYELYPFNGTSSAEFIIGTEDCSNLEGYCNGPLKPGSSYKVKIRAYTAPEKFTDTVYSYTFQTDTDNTALLAGITVPLVLIFLLIIIVIAVKRRRRHGPFTKKATDCHIKDDSMSIPESEIITSRPVKLHNFADHYRFLSADSDFRFSEEFELLKHVGRDKPCNAADLPVNRPKNRFTNILPYDHSRVKLMPSDDEEGSDYINANYIPGYNSPREFIVTQGPLHSTRDDFWRMIWEQNCRSIIMLTRCVEKGREKCDHYWPYDTQPCYYGDIQVTILNESQFPKWTISEFKVCKLDQTRIIRHFHFTTWPDFGVPDPPQTLVKFVRTFRDRVIPDNKPIVVHCSAGVGRSGTFIALDHILQKVQKHDYVDIFSIVYEMRKERVWMVQNEQQYICIHQCLMCALEGVEDVDSMRQEVHENQGYEGIQNLEMNMMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1C8</accession>
    <name>A0AAV6V1C8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="34">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="34">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="35" type="ORF">JTE90_021879</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(2E)-geranial + NADPH + O2 + H(+) = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54860"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:54861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:11261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>heptan-2-one + NADPH + O2 + H(+) = pentyl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54836"/>
            <dbReference type="ChEBI" id="CHEBI:5672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:87362"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:54837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>heptan-4-one + NADPH + O2 + H(+) = propyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89484"/>
            <dbReference type="ChEBI" id="CHEBI:89719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:54853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>hexan-3-one + NADPH + O2 + H(+) = ethyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54844"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88764"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:54845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hexan-3-one + NADPH + O2 + H(+) = propyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54848"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89828"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:74111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:74112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:69819"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:69820"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>octan-3-one + NADPH + O2 + H(+) = ethyl hexanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:86055"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:54857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>octan-3-one + NADPH + O2 + H(+) = pentyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:87373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:54841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>sulcatone + NADPH + O2 + H(+) = 4-methylpent-3-en-1-yl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16310"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:54865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:31979"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15724"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.14.13.148"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:31980"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 33 34">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 33 34">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="35">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="34"/>
    <dbReference type="EMBL" id="JAFNEN010000217">
        <property type="protein sequence ID" value="KAG8189376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1C8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034899">
        <property type="term" value="F:trimethylamine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000159">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002257">
        <property type="entry name" value="Flavin_mOase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01125">
        <property type="entry name" value="FMOXYGENASE5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 33" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 33 34" id="KW-0274">FAD</keyword>
    <keyword evidence="7 33 34" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="15 33 34" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12 33" id="KW-0521">NADP</keyword>
    <keyword evidence="14 33 34" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="KAG8189376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="509" mass="57991" checksum="7018E4B05E0CBC59" modified="2024-11-27" version="1">METKGNKRICVIGAGSSGLTAIKACKEDNFDVVCYEKSDTFGGIWWYHSEDISGRPSVMRSTVINTSKEMCAFSDFPPPSKFANFMHNTSMIEYFRLYAEKFDLFQHVLYNHEVTEVNMADDYESTGRWTVTVKNTSKNESFTETFDGVLVCSGHHIYPNIPNFKGLDDFKGTTMHTHSLKSSDGFEGKRVLVIGIGNSAVDAAVEISKVSKQVYLSTRKGSWIFSRLAPHGAPYDVAFQKRFFEALRSIDYFDFSEKIMEYFLNFKFDHEKYGLKPKHGVFDAHVTVNDALPNCVVSGTVIVKQNVKNFTKGGVIFEEEDEVTNIDAVVMATGYEIKFPFLSEKILKVSENNIGLYKFVFPPHLKYPSLAFIALVQPLGAMFPIAEAQSRWFTQLMKENVQLPSTPEMEKEVEERRKANAAMFVDSLRHTVEVFWIPYMDEICSEFGAKPNLWKLAFTDPVLFLSCLFGPCTAYQFRLQGPHTWDGARESIFSVWDRVDEPFKTCKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1Q5</accession>
    <name>A0AAV6V1Q5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_001284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Identified in the spliceosome C complex. Interacts with SNW1/SKIP. Interacts with CDC40/PRP17; this interaction leads to CDC40 isomerization. Interacts with RBM22.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000177">
        <property type="protein sequence ID" value="KAG8190675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1Q5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8190675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="163" mass="18047" checksum="54A136BF13F5DE3D" modified="2024-11-27" version="1">MMSEEPSFVVLETTMGAVELELYWKHAPKTCKNFAELAKVGYYNNVIFHRIIPDFMIQGGDPTGTGRGGSSIFGKEFEDEIHPDLKHSGAGILSMANSGPNTNGSQFFITLAPCQWLDGKHTIFGRVNSGMRVIQRIAKVPIDNNDRPLEDVKVVKSSVKNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2S1</accession>
    <name>A0AAV6V2S1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_010834</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000169">
        <property type="protein sequence ID" value="KAG8190975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2S1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016318">
        <property type="term" value="P:ommatidial rotation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050769">
        <property type="term" value="P:positive regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048056">
        <property type="term" value="P:R3/R4 cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000279">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043395038" description="EGF-like domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="228"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="266"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="303"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="341"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="379"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8190975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="538" mass="58351" checksum="E3F31374C8A82804" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V440</accession>
    <name>A0AAV6V440_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calmodulin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_002601</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000178">
        <property type="protein sequence ID" value="KAG8190646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V440"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004178">
        <property type="entry name" value="CaM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036122">
        <property type="entry name" value="CaM-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02888">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01053">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81327">
        <property type="entry name" value="Small-conductance potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calmodulin-binding" evidence="9">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8190646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="245" mass="27120" checksum="CD6F61558CB8E704" modified="2024-11-27" version="1">MILIAGNFILPNLKNAAASVLRETWLIYKHTKLVKNICPGKVRLHQRKFLLAIYTLRKVKLEQRKLMDNANTISDMAKTSNSIYEIVGELSQRQLALEDRIQSATERIAAIQETLDSLPDLIACRILAARKPSVFHQPPGSGPSWASISSVNLPAAQRRGSCTLGVPTIVPSLWYLGELWFEKCYISKDKSVSLPPASRQRALVGQHLVGQPASGTNEGKLYLRRCPPSCPGPDRQTTSLVIVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V441</accession>
    <name>A0AAV6V441_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000175">
        <property type="protein sequence ID" value="KAG8190763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V441"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="135" mass="15319" checksum="44947464E6CEAEFF" modified="2024-11-27" version="1">METWTKIPLIHTSQGQTQQQVSKVEASSQNICRSAITTRNEFFQDGGRQLSRQRREVVRPMGMGERKKRIFGVGGMQRGALGPFSSTQSTARRRMLERKSWRRGPGSYLPPVELATTVTTAAHAHWRKGNFFKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V492</accession>
    <name>A0AAV6V492_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_019594</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000158">
        <property type="protein sequence ID" value="KAG8191530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06731">
        <property type="entry name" value="PDZ1_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06732">
        <property type="entry name" value="PDZ2_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06733">
        <property type="entry name" value="PDZ3_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06734">
        <property type="entry name" value="PDZ4_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06735">
        <property type="entry name" value="PDZ5_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000005">
        <property type="entry name" value="Membrane associated guanylate kinase, WW and PDZ domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000144">
        <property type="entry name" value="Membrane associated guanylate kinase, WW and PDZ domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000001">
        <property type="entry name" value="Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000003">
        <property type="entry name" value="Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000232">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316:SF40">
        <property type="entry name" value="LD27118P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316">
        <property type="entry name" value="MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="6">
        <location>
            <begin position="102"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="474"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="668"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="1108"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="1211"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="1319"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="774"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="863"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="774"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="825"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="889"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8191530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1409" mass="155289" checksum="149F966017B95F3B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5E4</accession>
    <name>A0AAV6V5E4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_022821</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000151">
        <property type="protein sequence ID" value="KAG8191832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5E4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002224">
        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
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    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017241">
        <property type="entry name" value="Toll-like_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037595">
        <property type="entry name" value="Toll-like_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="867"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="713"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8191832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="892" mass="102965" checksum="13A4EF7FC66AEBFD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5Z1</accession>
    <name>A0AAV6V5Z1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_008771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000153">
        <property type="protein sequence ID" value="KAG8191706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5Z1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043473550" evidence="3">
        <location>
            <begin position="20"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8191706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="778" mass="82766" checksum="0B283BD413F90F7B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6R8</accession>
    <name>A0AAV6V6R8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6R8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043865680" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13796" checksum="475B752297DCCBCD" modified="2024-11-27" version="1">MQQEGAFVVAVWPLATGLAPVPMATACVGVAGHRKCVKPAAAHLPPGRARFPLSLTCGSPWKPPPPPPHQWTAHQQMDERERTVIFGHLLFECSEPGPSRFFGSYRRTTGDGARHFVPRRRRAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V834</accession>
    <name>A0AAV6V834_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000152">
        <property type="protein sequence ID" value="KAG8191791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V834"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043989343" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11935" checksum="77C7750AC6375E39" modified="2024-11-27" version="1">MLTVVQLCFFVVCSGKVGLVPFFPKGWHGFCAVRRDFDRSGRVCEHFVLERLEIVNGCLLKCRLFVKTVYLMHKPFKDYSAWLLRTWSGKSFHPLSNICYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8W2</accession>
    <name>A0AAV6V8W2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_009961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000143">
        <property type="protein sequence ID" value="KAG8192198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8W2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061513">
        <property type="term" value="F:glucose 6-phosphate:phosphate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051337">
        <property type="entry name" value="OPA_Antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43826">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43826:SF3">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="4"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8192198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="427" mass="45430" checksum="F6388FCCC4C32DB0" modified="2024-11-27" version="1">MESVWVTLFVCVACYAYNRKSVSFVSPKLIEDGLDRSHAGLILSCQNGAFALSKFIVGVLSDKTNPRHVFIFGLLLSAAATLAFSSAPVTSISVLCGLWSLNGLAQGCGWPSCAKIIRQKASPSQFGTLWSVLSSGNNFSGSLSPFISSYIVLHYGWRTSVFSAGCASVVLGILGAAALKYSLGTDENSNKEHEKSTQQKSSKEGKDAADGSLIDLLLDPFLIMVSAGYFMVFCARSVLLDWGQLYLIEDRGRSHHEGSAFASSLETGGFLGQIAAGFITDKLINLFTGSSQSSVRLSVAVVSMLGSVSLLHALQVTVTEESSTAWITSLGFALGASLYGPIAIFGIVSTESAPAHLSGKSNAVAALAANLGAMTSGFPCCYLAKHYSWSTVFFILEVTTGVLLLIIFCFRNLQPKLLQKEAQKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBK4</accession>
    <name>A0AAV6VBK4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_028148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000132">
        <property type="protein sequence ID" value="KAG8193031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBK4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043383781" evidence="2">
        <location>
            <begin position="27"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="154" mass="16672" checksum="378E7A50705F1283" modified="2024-11-27" version="1">MMSCALVWKRMLVSTVLLLLSCCATALSRRSTTAGIYGRVVPIPAGTRAHYNLQNFAGPGTYKFGYDTGSGPNQSFRQEERGADGKVEGRYGYVEPSGALRVVEYTADAQGFHILKTRTLVPDMKPKAAVKVRTPFVGPLPPFIPTSYVVNLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VC53</accession>
    <name>A0AAV6VC53_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">sn-1-specific diacylglycerol lipase ABHD11</fullName>
            <ecNumber evidence="3">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha/beta hydrolase domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_023720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48596"/>
            <dbReference type="ChEBI" id="CHEBI:11152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:90605"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77107"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:77129"/>
            <dbReference type="ChEBI" id="CHEBI:186738"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75468"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38503"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:77272"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000120">
        <property type="protein sequence ID" value="KAG8193468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VC53"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="36"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8193468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="241" mass="27881" checksum="D1DBC141B597AB64" modified="2024-11-27" version="1">MEFNSSLPTDSKNKIVPVKLYSMMYTPENYDETLAPIIFIPGFFSTNRTYTSVRLKISRKTRRRIYVIELRNHGLSEYTDDFSLSHCIADFENFMETSNISRAVLAGHSMGGKLALAMALKHPDKIEKVIVEDANLVLSKHAREEYSKNLMLMKFLNRKLIELPSDVSESEAQRELFPHVAKFWPKVAKNFSKVKSQFRLPLCTNASDLYRRYSSISRRVVIYWSAKGLECFLQTFSEPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VC67</accession>
    <name>A0AAV6VC67_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_023734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000120">
        <property type="protein sequence ID" value="KAG8193483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VC67"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000437">
        <property type="entry name" value="Beat-IIIc, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="131"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8193483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="258" mass="28521" checksum="B2A079E07DEBCD31" modified="2024-11-27" version="1">MLTLYFTGSSWGKSVRVTELRVPPQAVFGQSVTLVCSYDLGTEELYVVKWYKDDLEFYRYEPKDDNQSVYFPQPGIDIDLSKSGKHMVHLKNVALDSAGTYKCQVSTDAPTYSCVQAVKEMNVIILPSEGPTISGGEGNYDFGDNVTLNCTSAKSKPAAKLSWLVNGKPVDDNETIDHGTIHITDNLEATSKTLQLPVTERLLSKGKVAIKCEASFYGTVAMISRDITIIEIDSASSCNFSNIFLLIIMFISLWPGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCQ8</accession>
    <name>A0AAV6VCQ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">tRNA (guanine(10)-N(2))-methyltransferase TRMT11</fullName>
            <ecNumber evidence="12">2.1.1.214</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">tRNA methyltransferase 11 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_029551</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the TRMT11-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 10 (m2G10) in tRNAs. This is one of the major tRNA (guanine-N(2))-methyltransferases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>guanosine(10) in tRNA + S-adenosyl-L-methionine = N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43128"/>
            <dbReference type="Rhea" id="RHEA-COMP:10355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.214"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:43129"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the heterodimeric TRMT11-TRM112 methyltransferase complex; this complex forms an active tRNA methyltransferase, where TRMT112 acts as an activator of the catalytic subunit TRMT11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="12"/>
    <dbReference type="EMBL" id="JAFNEN010000114">
        <property type="protein sequence ID" value="KAG8193817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCQ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="17">
        <location>
            <begin position="73"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="16">
        <location>
            <begin position="252"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8193817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="506" mass="58781" checksum="81D372843AEE52EA" modified="2024-11-27" version="1">MRSTAQLLVEVLVTSSRGFSNRDSSALKRPLCGVTRRSRCSTDFVHPSRPQNYFKYYLFYKMSKLFNYGRSVLLWYCHDFVNFRLQELYSISKMYNIKFEWLVEPSLKDPFFLINVSSQTDVEKIMSRTVLIRSAYELWAKSKTLTDIHSKMKDVPKSFSEPYRKKDVSFRILVESFGKKINLDYKVKRIEELEFMDFKGPIKLNNPDQSFVFMEYYGCDRNNSPEEPFQYFFGRWLADGQRLISHKINLSKRKFIGNTTMDPLLSLIMANMACVKPGDIVLDPFVGSGGILVSAAHFGGCVFGTDIDYLMLHGKAKPSRLNQKKRAPDENTRANMKQYGYESQYMDVLVADASLPLWRSPSFFDAIITDPPYGIRESTEKIGSEKNCKIPDHLAPNHIPSKVTYTLQDIIEDLLDFSSIHLKLHGRLVYWMPAFNEDFDKKQLPTHPCLELISFCNQALTEHSSRYLITMEKIKENNNSEEKSFVPESASNFRKKYFETNKKKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VD67</accession>
    <name>A0AAV6VD67_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000117">
        <property type="protein sequence ID" value="KAG8193621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VD67"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8112" checksum="CAFF68D63A6CE14D" modified="2024-11-27" version="1">MCVAGVELTLLDSKSIQRLGSGRTPLCPPDRSRRCPCANTRPWTERRCSCRGRCGQNNVLLMDIVKYVRCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDH0</accession>
    <name>A0AAV6VDH0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_027995</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus</location>
            <location evidence="13">cis-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000100">
        <property type="protein sequence ID" value="KAG8194680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDH0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="16">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="17">
        <location>
            <begin position="134"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8194680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="213" mass="24392" checksum="43A7455E7BE5D3CF" modified="2024-11-27" version="1">MILKTMLARIGDGLILAESVQHDEEEGKTNYEYHSQAKSLFRKLNAQSVAICSIETGPYYFHYLIHDNVCYLALCEKSFSKRLAFAYLEDLKNEFSTHYGRMAASATRPYTCIEFDTYMSKAKKSYSDNRARRNLTHLNTELQDVQRIMVQNIDDVLQRGAALSDLDSKASNLSLLSEKYKKDAHFLNMSSAYTKLAAAATVVFVVFLYFWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEC8</accession>
    <name>A0AAV6VEC8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Antifreeze glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_003599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000111">
        <property type="protein sequence ID" value="KAG8193998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEC8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043664048" description="Antifreeze glycoprotein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="37550" checksum="1B56301C02981934" modified="2024-11-27" version="1">MREVPRFCLILMLIGCVLFQATTLSAAPTPAALIIVKREATAATPATAATPATAAIPVTADTPATEATPATAATPATAAIAKRAAIAATAATPATPATAAKAKRAATAATPATPATPATAAKAKRAATAATPATPATPATAAKTKRAHPHSQMQHTQSTPATPATPAKAKRAATAATPATPATAAKAKRAATAATPATPATPAKAKRAATAATPATPATAAKAKRAATAATPATPATPATPATPATAAKAKRAATAATPATPATPATAAKTKRAATAATPATPATLATPATPAKAKRAATAATPATPATPAKAKRAATAATPATPATAAKAKRAATAATPATPATAAKAKRAATAATPATPATAAKAKRAATAATPATPATAAKAKRAATAATPATPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEF7</accession>
    <name>A0AAV6VEF7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000094">
        <property type="protein sequence ID" value="KAG8195079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEF7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="552" mass="63772" checksum="790FC9066ECC322B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHC7</accession>
    <name>A0AAV6VHC7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_001396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000089">
        <property type="protein sequence ID" value="KAG8195380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHC7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8195380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="107" mass="12622" checksum="FA01822B424AD473" modified="2024-11-27" version="1">MNHGRLLGVGKPSPLCPTIDDDKDPVFYRHPGNCSVYFLCSHGFAYEFQCPARLHFNLKEKICDYESTVNCTEAIKFYERYRRLRPTGQFEWGDFAREYACFFCKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHH3</accession>
    <name>A0AAV6VHH3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_001419</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000089">
        <property type="protein sequence ID" value="KAG8195407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHH3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042634">
        <property type="entry name" value="MOX-1/MOX-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328:SF7">
        <property type="entry name" value="BUTTONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328">
        <property type="entry name" value="HOMEOBOX PROTEIN MOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="309"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="311"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8195407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="389" mass="44172" checksum="7AB7E8BC7FDA2D3E" modified="2024-11-27" version="1">MHTNSLDKATPTSSNADKFWMQSKFPFLSNTDALVQPLTQKFEPYSNIFDTHNFTDFIDFMDLDGSSTTSDDWLCNDISLETSSDSFLEDCCSLDLSSPETKECNQKFEDIPTTDGTSSSEGLCYVCPDYQQKNENVRDTTPNFQGSTGDNELGKTSLDGFKNFSNSKCFGNQVNFGVSTLWTAKHFEKYFSSLCLPANAKIPHQSTTTPSQKQQRVVPESTSIDGLQESGTNVENNELDYTGGVMECDALGFDALTNHHTTRDLSSELLKLQKQINGTTELLLADDELNRALAERSFLSDSGNEDESGKPRKERTAFSKQQVQELEEEFAQHNYLTRLRRYEIAVALNLTERQVKVWFQNRRMKWKRTKGVHMRTKEKFIKEIIDTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIH8</accession>
    <name>A0AAV6VIH8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho GTPase-activating protein 29/45 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000077">
        <property type="protein sequence ID" value="KAG8195830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIH8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057028">
        <property type="entry name" value="RHG29_45_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24235">
        <property type="entry name" value="RHG29_45_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho GTPase-activating protein 29/45 N-terminal" evidence="2">
        <location>
            <begin position="46"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8195830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="197" mass="21694" checksum="6326E4AA852716B6" modified="2024-11-27" version="1">MDPLPPTTTSSPLAAGPAAARSLSVNSVSSEGSAESSAHLVEQEDIVVLTHDVRSFKEALGKLRRIFHPERDKTETMRVAAHERLGEVLRILRSILEKYPPIQSTELLMTAGTLIQQVKGYSYEDEKSDPSLFFDAIDQLALAFSSSYSNPVTSSGQRPLFRSSRDTLSAATTKEKKMLQIVKPQHIPRDGLTPKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJJ4</accession>
    <name>A0AAV6VJJ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxypeptidase</fullName>
            <ecNumber evidence="5">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_007822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJJ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904715">
        <property type="term" value="P:negative regulation of chaperone-mediated autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000335">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF201">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043104635" description="Carboxypeptidase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8196082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="459" mass="51946" checksum="17E3AA9FA53659DA" modified="2024-11-27" version="1">MTFLKLFIFVLSCLCITFATHPDEVLDLPGLSFGLNYKHYSGYLNATSGRYLHYWFVESQGSPSKDPLLLWLNGGPGCSSLDGFLSELGPLHVSADGKSLYNNTYSWNRIANVLFLEAPAGVGFSYADNKKYFGDDDSTSYDNYVALQHFFQKFPQFKKNDFYISGESYAGIYIPTLSVRVLTGPAKINFKGFAIGNGLLDEANRTNSIVFFAYYHGLIGVKFWNSLSQYCCNGIATPQTCNFANPDSSDCSNAVSKVQDLINGGELNFYNLYADCAHSPEKISRYLVDKRNLLRMFPKPTNVERDRLKDYLPCIDTSNLRKYLNQPAVRAALHIPTKVQEWEICSTDVENGYKQIYNTMFPQLLQLINSGKLKGLIYNGDVDMAANFLGDEWFADNLGFKVLADFKPWKFNDQIAGFVKSYKNLSYLTIKGSGHMCILKDIVEDYLRTLRIAICLWWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJK7</accession>
    <name>A0AAV6VJK7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATPase V1 complex subunit H C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_006584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit H is essential for V-ATPase activity, but not for the assembly of the complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000066">
        <property type="protein sequence ID" value="KAG8196675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJK7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF1">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="7">
        <location>
            <begin position="452"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8196675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="588" mass="69209" checksum="7DC323AA6BB16283" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VL06</accession>
    <name>A0AAV6VL06_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_013834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000072">
        <property type="protein sequence ID" value="KAG8196351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VL06"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118:SF12">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8196351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28734" checksum="019FD20C682C5938" modified="2024-11-27" version="1">MGYEVMQKIWKIFLYIFVNNLLFCVCELVDLTHPFDDSTFFWGTAKPLQIKTTFNGTKPGKGFWFQSEGICAGTTHSGTHMDAPCHVIEGGWSISDIPLHNLVVNAVVVDIRDDVGDDPDVHLQVGHLTRWEEENMKIPAGSLLLICTGWSRFWPDREKYLGTAGFDTRLMRFPSISGAAAKWLRQHRQIVGVGIDSITIDVNNGKEESHLSLLGGNIYALENLKDLHLLPATGARIFVMPALLKGASGAPCRVVAEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLD8</accession>
    <name>A0AAV6VLD8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_001553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLD8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18106">
        <property type="entry name" value="SpoU-like_RNMTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053888">
        <property type="entry name" value="MRM3-like_sub_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051259">
        <property type="entry name" value="rRNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191:SF2">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22435">
        <property type="entry name" value="MRM3-like_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRM3-like substrate binding" evidence="5">
        <location>
            <begin position="92"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="4">
        <location>
            <begin position="191"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8197622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="405" mass="45873" checksum="276D7E4FD09C7D25" modified="2024-11-27" version="1">MSLQKSLALRNLSKVCFFPRFYGTKVLRRKPIRVLNVPTEQTSLSSNENVSKIQLTKPVGDDVGFPKENESKIVVPEYEKLKQNDARFTKILTIIKNRKLREKDGRILLEGKRLINDAISAGMELKTIYFSKEKDLADINFKNQQKAEILKVLYKTLQVWSDLTTCPGVMGVFKRPTAEMLHVLSEPAVPVTLICDNIREPGNLGSLIRNAAAAGCENILLMKGCVDPWETKVLRAGCGGHFRIPIVNDIEWTHISNYIPKNSTILIADNSADIDGSSPTPEFINYDEVIEEDDEKKYVALNEFDQPLAIDETYNERSELQKYREINIPCYLYSSIKYPKESIVLYVGGESHGVDARITKLACDYGGKKVKIPMENCMESLNSTFAATIILYEIKKQFLELYVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM10</accession>
    <name>A0AAV6VM10_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_001608</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM10"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000043">
        <property type="entry name" value="Scratch family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000169">
        <property type="entry name" value="transcriptional repressor scratch 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF38">
        <property type="entry name" value="PROTEIN SNAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8197684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="299" mass="33047" checksum="70B42C10B06350E6" modified="2024-11-27" version="1">MPRSFLVKKVKHPVDHGNRWSYHEVSSPPVAIHYATDYDYDLPTKDPELQEVVATCHLHDRTNNGSKNDPPWIAYEEDEDEEMEDSPASSCNSSSSDESNNSTGSSKKAFLVDGRARRRKSGGGETGDAVVTRVCRYTCGECGKQYATSSNLSRHKQTHRSPDSSLAKKCPTCGKVYVSMPALSMHLLTHSLSHVCEVCGKAFSRPWLLQGHMRSHTGEKPFGCASCGKAFADRSNLRAHVQTHSPLKGHRCGRCNKSFALKSYLNKHFESACYRLEGLVPEEGGEEGDDESDHSTPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM83</accession>
    <name>A0AAV6VM83_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_027561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM83"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="163"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8196848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="472" mass="54779" checksum="450F5C2C1CD9CF43" modified="2024-11-27" version="1">MFPTFKLITGKVSTLSFQNVSKSFIHFPKKNLHKLNTTSKRDQQKLVLDLKSTPEQQNILAEGESRYYIENGLRKVYPYFYQHTVHCKGRWIDRTILDIYHDEFLYPIEHITQRILTGAVRVNGEIVSLDYRLKHADVLTSNTHRHELPVLATPIKVIYEDDNVFVIDKPPSIPVHPSGLYRFNTVTFMLAEEHNRKDVFLTHRLDRLTSGVLVIAKDRKKSRQLHDEMLVRNVQKEYLCRVDGEFPDGVVLCDKPLKQFYKKIGVSMVLPSGKPSLTEFQKLSFNGKSSVVLCRPKTGRTHQIRVHLQFLGYPIVNDPLYNSYCFGPNKGKDGEINKTYTNLLNDLVIKHSASWWLVNKATGEDPKPIVDYSKDVDEHLKLELHDQMNISPEDLYSSMSYGVIDEKLQGTVYRKDETRITSDNSCYFCSKVFRDPKPSNLVMFLHAFKYKGENWEFATEVPQWAQSDWDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP31</accession>
    <name>A0AAV6VP31_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_001564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP31"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="41"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8197634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="322" mass="37399" checksum="7B8DE44371DCF613" modified="2024-11-27" version="1">MSTNVAGKKIRPRYQDVDGWRLPCQFSPEAFRSTLAYKPRPDDLFIVTYPKCGTTWMQTIVSCIFRRGQPFQTGLEFFSQCPFLEMTGAEAALTMKRPGALKVHLPFHLTPYSPETKYIFVARNPKDCCVSLYHHTKNIPIFEFTEGDFDDFFEVFIEGETDFGDYFDNLLSWYEHRNDPNVLFITYEQLQEDIRTNVLKIAQFMGSQYKEALDKDEKILKDVILNSSFKFMKGRFSKQFADFAALPREEIQNNPDIPSGLKTLFGGETKAFNDDSTSNFVRKGIVGDWKNYFSPMQNARLMKKYRERTAGTDIPNLWGNYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSB5</accession>
    <name>A0AAV6VSB5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_000860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSB5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="22"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8199767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="841" mass="93608" checksum="D2A0B3C2D11A1F0F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSX6</accession>
    <name>A0AAV6VSX6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000030">
        <property type="protein sequence ID" value="KAG8199161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSX6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="237" mass="25847" checksum="4F47CF2FADA76064" modified="2024-11-27" version="1">MSVRLSVVSRVLFFCLYIWRDSLYFNHCFLVEEFVNFAKGFRITCIRQVRQSSVSPSRPEPGRNYQPVNLAARSSLPTACESSSETSYTPTSKCLNYHGYHLSCVKSCPGMQQQQTNALVSTLLEQVGIMSKYISTLQIPPPPVIHAAQSTAAPVPPAQCPPTAVISPSQFVTSIVSKSKSQYLLPLNKKPKVSTELPLSPPLPKNASVELSAMDTSSPPSHPIAETPGQAPQTPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTQ1</accession>
    <name>A0AAV6VTQ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphodiesterase</fullName>
            <ecNumber evidence="8">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_001898</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="8"/>
    <dbReference type="EMBL" id="JAFNEN010000020">
        <property type="protein sequence ID" value="KAG8200040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTQ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000003">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0140">cGMP</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="290"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="659"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="366"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8200040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="690" mass="79738" checksum="D9F6CD51BE971BA4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VV19</accession>
    <name>A0AAV6VV19_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_015899</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cholesterol(in) = cholesterol(out)</text>
            <dbReference type="Rhea" id="RHEA:39747"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000023">
        <property type="protein sequence ID" value="KAG8199913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004765">
        <property type="entry name" value="NPC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="2A060601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043888157" description="SSD domain-containing protein" evidence="18">
        <location>
            <begin position="23"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="710"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="783"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="817"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="878"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1152"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1176"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1201"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1244"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1277"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="19">
        <location>
            <begin position="676"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8199913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1332" mass="149167" checksum="D6CC6214001003C4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VV55</accession>
    <name>A0AAV6VV55_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_000612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VV55"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="36"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="36"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8200539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="630" mass="71760" checksum="58C3DB080498308F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVR4</accession>
    <name>A0AAV6VVR4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(+) ADP-ribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_002717</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.30" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000009">
        <property type="protein sequence ID" value="KAG8201042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVR4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="14" id="KW-1053">Target membrane</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="19">
        <location>
            <begin position="223"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8201042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="414" mass="46654" checksum="E032D7F8B232E336" modified="2024-11-27" version="1">MDLKLFEELLPTNDKYLMDLHTAASIGCEERVHDIIENAENKSFINHQNSSGWTPLMYAAGCANLRIVGLLLEEGAFTDLKNNEGHTALILASKCGSTDASGAFVNDRDNNGWSALSYASAFGHRSVVQLLVEKGAMVDQGDKVNGMTPLMLSSAAGHEMIVKDFLQLGLNPSVKSKSGDTARSLALKNGHHKVKNLVDAHMCSKRNYQLTNVRKTDPNGQMDLQMLLDELNLTKYYYVFENHGIDINMFFMLTEDDLKEIGIQLLGPRKRMCMAIAEWYKRNLSRGESEDPAFCSKLVLENKRLLQKKEELENQLSREIELRKTADHNLSEGIKTLKNFSDTIQRTMAYTLLLQEKAKQSHMNLKKLVCCTPDAHWTKLKSDLAIPLIDGIDSLLNDIHHHTYLALQQTNFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXC6</accession>
    <name>A0AAV6VXC6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_019886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000007">
        <property type="protein sequence ID" value="KAG8201247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXC6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000080">
        <property type="entry name" value="Putative synaptotagmin-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF252">
        <property type="entry name" value="SYNAPTOTAGMIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="160"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="290"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8201247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="430" mass="47871" checksum="E11B96C4A5DF65CD" modified="2024-11-27" version="1">MDEWAVALILIGVSVVVAAALVGMCRLLGGWTYLFAFVTGDKEERTQLASHEENGYITYPPPNYYPHSQNSRPQFIPQQSFSDSLKSVDVVVPPIPPPPDQPTNRRFSLDIARRASIDTDLPDILSVEGGSNAKLQRAMSCDSVCSDTSVVMDTMESPQNNGELEVAIEYSSKTEELIVMIIRARNLMAFDSTIAKVDSYIRVSLHPDESSIMQTALHRDNKDPEYNERFVFSAPRFSLRDRVLKCTAYTCDKSTNTVLGQSDLKLASVNLKEPHKSWLPLTDSKRRPVGCGELLFSLSYLPTAERLTVVLVKARNLVWAEGKESADPFVKIYLLQKGKKISKKKTSVKRGDRNPVFNEAMIFSVPAAALQNIQLRLTVAEYQAEGKTPSVGHIFVGPSCSGKALSHWNQMISAPRKPIAMWHPLKKREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VY22</accession>
    <name>A0AAV6VY22_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_022265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VY22"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8200643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="174" mass="18604" checksum="4611F5F5EE750A4C" modified="2024-11-27" version="1">MVGILYVAVIDEYGVTRQEATVPFSIRNAIRCLSGPLVGIMGQRFGIRTITFYGGVIASAGAALCYIAPNIVWVSVLWGGVHGFGFAMANTLFQVIVNQYFQKYRATASGIALSGACIGSLGFPVLLEWIIGTFGLSGGFLIVGGMVMHVLPPSLLLSSPQWIEHPEGYARLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZF3</accession>
    <name>A0AAV6VZF3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000011">
        <property type="protein sequence ID" value="KAG8200936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZF3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="9747" checksum="049CA3C81CBCF6B3" modified="2024-11-27" version="1">MKQPNKPKFKFRIDTLISHIKTRSQASHPYVQRAPPTPKQTCRLSCGLVITGDIMAAATRQIAKGPSLSSRSPSRITNESPCVFELPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZU7</accession>
    <name>A0AAV6VZU7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000007">
        <property type="protein sequence ID" value="KAG8201213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZU7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="255" mass="28666" checksum="CEFE79778D9144A9" modified="2024-11-27" version="1">MTFVAFRCGNVVREGSVRNRKNGRSCPPQNATPALVLVTFQKPARLQSKVDLCGSHIRSGSTFHSAPKILVSDDSFLANKFCSRVTCENVRKGLPAVSLLPYDKDVEEHAWERNKNHILNDFLFKGIIHATCLDAPDRRPATCCCCISIHNSVRPLWPCDACLIKYGARPPFLTGLIPIIRALRWHQERLKTAFNAGFYVSRNGNGKFSKLRLHSSSAPRDGPPQSKPDQTLMRPNQARSKRMARSRQQRAEESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W327</accession>
    <name>A0AAV6W327_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W327"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="9148" checksum="BDEDD0795CDE68CC" modified="2024-11-27" version="1">MHLLPFKVTKLLEIWQNSRIPPLNLDTRLRSKQKDSVNVLLVLRCDNFTDQKRFFVHRYFIPSLERNGIKRSLLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W4D2</accession>
    <name>A0AAV6W4D2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BCL2/adenovirus E1B 19 kDa protein-interacting protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_010504</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NIP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W4D2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097345">
        <property type="term" value="P:mitochondrial outer membrane permeabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010548">
        <property type="entry name" value="BNIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15186:SF5">
        <property type="entry name" value="BNIP3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15186">
        <property type="entry name" value="RE48077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06553">
        <property type="entry name" value="BNIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8202145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20885" checksum="FEDB2EB0FA932168" modified="2024-11-27" version="1">MSHSVKSVDEDMLIDSWVDLNATGEISRGSEGSQKRSTPIASLISSGKLEKLLWEAQRESCQSSLIGSGISSQRGSPKSPHSPVTEEAAVDETFPSQVLAGLRRHGSTDWIWEWSSKPEQRPPKEWKLKHPRPILSLRNSKVAKSGLFSPDIITILIVSNLLSVLIGCGIGFYMTKRAGGSEFFYWSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TD84</accession>
    <name>A0AAV6TD84_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Collagen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007268">
        <property type="protein sequence ID" value="KAG8155684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TD84"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="7746" checksum="F71FC86E668FA122" modified="2024-11-27" version="1" fragment="single">PSRSYGRTGSSRSDGPLVFPGDRDKPGPPGAPGSKGEVGLPGAAGPPGEKGEWACLVTPDPQEVEMDLMDLTDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TE17</accession>
    <name>A0AAV6TE17_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006325">
        <property type="protein sequence ID" value="KAG8156111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TE17"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
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        <location>
            <begin position="537"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8156111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="606" mass="69726" checksum="6E5EDE524139B71A" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TE39</accession>
    <name>A0AAV6TE39_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">JTE90_012840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Araneomorphae</taxon>
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            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006366">
        <property type="protein sequence ID" value="KAG8156048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8156048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="131" mass="14322" checksum="FD661040B1349B67" modified="2024-11-27" version="1">MGLAPTLGNSPGQGDLLQSPSPARSLLNATFPHALASGGFGAGLLPVHSPLLRESLRFSTHHVPRCILQRGEETTRVEKDDKRVELATRTAFNSHHPQPMLRSQYAPYSHRNNFRDGAHGRGPDHSQEAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEK1</accession>
    <name>A0AAV6TEK1_9ARAC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Erigoninae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005940">
        <property type="protein sequence ID" value="KAG8158045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEK1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8158045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="145" mass="16161" checksum="E299D13B44BEC85E" modified="2024-11-27" version="1">MIFKIRKSDSHSPCQYETKFNERSYPEGNIRGTATRWFISLTAARPDLPIDLTSEPLLDLHQSFLWASSCPGIVQHLWVPTCAPQTPPLPQVERGRVSGRPRPAREPGIPNAAEPPPACTFISPPGFIQGDPLTRRTCRLSFGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TH14</accession>
    <name>A0AAV6TH14_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
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            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004634">
        <property type="protein sequence ID" value="KAG8170962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TH14"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="114" mass="12453" checksum="D5150DA380AB1208" modified="2024-11-27" version="1">MGQPRSLRDRENPSKGRDFCQNETLLVFVSLPPKGKGGLKNSPKPRDREMGPWGTQVGFNATKLGDARRGPGEELFFSFFKIFVSPGNRSPGEKGPFLVKARALRCPGAPLLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TH35</accession>
    <name>A0AAV6TH35_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004369">
        <property type="protein sequence ID" value="KAG8171144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TH35"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="180" mass="20485" checksum="6952D46AF841F364" modified="2024-11-27" version="1" fragment="single">MFQGIESVFFTEIFERNSDSFASFSPNGFMLACAADCQALVWSVDTKAILHKFICDQPIDDIVWSPNSELIYCHISKQNSIQVWSVVNLTWRCKIEENPLSIADVFWAPDSQHLLVVSEFHIKITVWSLVSRSITVIENPKAIKDGVAFSSCSKYMALVEKKKSEDFVGIYTCDTWEVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TH95</accession>
    <name>A0AAV6TH95_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004537">
        <property type="protein sequence ID" value="KAG8171043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TH95"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="183" mass="21122" checksum="AA33B34FAAF3F69A" modified="2024-11-27" version="1">MGGVHSSLTKTPQCPEGYYCVTRSSIVASRLKGFGYRKLKAHVGKNNKVYWLRSDVAALVGKCEANVFPNNDGYSPRAVLDYPCLTSSRLLKTRQVSAVLKIHNKELSVLFEKAIQHRNPISWYVENKIPFRVLFQLPIHKQKVERSQLQTQRRMRINDNQKKCLPRKCKQLPKGFYTEDKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TI11</accession>
    <name>A0AAV6TI11_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004415">
        <property type="protein sequence ID" value="KAG8171106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TI11"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="9823" checksum="8BAE89A078AD9C83" modified="2024-11-27" version="1">MTIDLHVEPHYGHTPEFPLASSCPGLVPIFRRCQTCAAQTPPLPQVETRRVSGAAPPRGERGSRSGRPPRPCYFISPPGYYKTQTSRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIH2</accession>
    <name>A0AAV6TIH2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003855">
        <property type="protein sequence ID" value="KAG8171539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIH2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="294" mass="32311" checksum="E269BAEBE7ADC295" modified="2024-11-27" version="1">MSGILPPALSQPIGVLDCPAIDDSIVVSASAPPDLAGFAGPEPLSAFTSLTLDGVSEPLSELCADAPLTEELASISSNLATLLEEEGLPASPTPQRIVYNRYRVDPVGAEPNVSAARLKIFHYLKCLFEAASAADSPLDVAWASFLEDFDLDLLYAKVSRALDEVIPVIRVPKSHRRIPQRPRDTDSGAPLSRREARKQDYATFQKLFKKNPKRVLEKILDPPSEGFLFLVPPIFPTFGGMSCRCPRVLDPIRTFRTTPFLVATFRVFGFPLREMRLSGHDPSPLRLPDLTEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIH3</accession>
    <name>A0AAV6TIH3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003745">
        <property type="protein sequence ID" value="KAG8171624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIH3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="10029" checksum="9C80A8A8446D424D" modified="2024-11-27" version="1">MCASQWVLNKPGGEMKVQAGGGRPHSGSPFPRGRGAPETRRVPLVEVAEFERTRWDPKDGKLCPDRTRPEETLVEVCSGSDVQIDRQIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJD2</accession>
    <name>A0AAV6TJD2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003568">
        <property type="protein sequence ID" value="KAG8171793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJD2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="8916" checksum="C482C5532B7BE416" modified="2024-11-27" version="1">MFSNQDFFGDAEIHIERKISTMVGIYRSLGPLLVKLESITCKTSTGEAAQMRDYYRACEARVLKALIQVSLISISCKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJQ9</accession>
    <name>A0AAV6TJQ9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003652">
        <property type="protein sequence ID" value="KAG8171706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJQ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="239" mass="27183" checksum="505F7D05D2321B25" modified="2024-11-27" version="1">MQTSAFRVRDIAEERSELFLKSLADKRDIKAFKVELGTEEVKRSLHILQDVKKEKHDTEDQLSPKGCSSAAASSTSTDKDGLEIVYESPGSHLHPEYIQNPPEIENQVTTTNCKRAIQISYEDDNSNQDPQARKKLRILPVVIPDGIRQIISGIPDQILDIQELEAFFTHAKKKSRPLEIVKVYTSDVEGFKRQLLEISRKYYMSPNVGSNADIQFVKMLQGVLKRFENPPPRNVSMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TK21</accession>
    <name>A0AAV6TK21_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002856">
        <property type="protein sequence ID" value="KAG8172290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TK21"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="112" mass="12414" checksum="B91B04B7D56294DE" modified="2024-11-27" version="1">MEVIYIPAMTYAKTSGVIMTSIPPHTSHKMQPLDKTVFSPFKSEYFQASGEWMATPGNHEKPVTIYDVAQLVGKAYAKAFTPANILIGVLVTGIYPLTQILFKEEEFVSSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLH6</accession>
    <name>A0AAV6TLH6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002338">
        <property type="protein sequence ID" value="KAG8172815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLH6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="9999" checksum="3FF419E2757FE5FF" modified="2024-11-27" version="1" fragment="single">MCIREIIQVIDATGKIPAGILEGTSVSMGDYDECLDIEVTKKDEAPKTPEDVVFKGQYCMLELHRPETINRAIEDFQNGNVDTPIAKTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLW5</accession>
    <name>A0AAV6TLW5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002477">
        <property type="protein sequence ID" value="KAG8172671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLW5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="343" mass="38848" checksum="2286541ABD9B29E6" modified="2024-11-27" version="1">MKKRPKQRPIRVLVECNERLGPARDGFWGFTTEYPVDGGEDLMYPISIRELARCKIKYTSPALPDGVSAKIWNKVPDRVKAKLFTIWLRVGRVPESVLESRTIFLPKKEETVLPSDTRPISISSVVLRHFHKLLTGRLSELVEPKLDSKQCGFRPRDGIAFCISQLDRVLTDTRNEKRGLCLVSLDLCKAFDSISHQAIFYTLESMGLDKKFISYLRYVYGNGRTRLTYGGEESAPILPGRGVRQGDPLSPLIFNVVFDNVLRSVPDQLGLRCRGEWVSKLAFADDLVLCAENAVDLQHVLDMAMPVVRACGLKVNEQKSVSLTWLACGKDKRRIYDHRPTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TM77</accession>
    <name>A0AAV6TM77_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat-containing protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_012157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat GAD-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002468">
        <property type="protein sequence ID" value="KAG8172679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TM77"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001319">
        <property type="entry name" value="Gastrulation defective protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8172679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="45288" checksum="D1C1882AAAA9C7D0" modified="2024-11-27" version="1" fragment="single">GYDYDVKVWDFAGMGVSVQSFRSLRPCEAHLIKNIEYNVTGDSMLVVSGNAQAKILDRDGFELMECPKGDQYISDMSKTKGHCAMLNDGCWHPRIKEEFLTCSHDGSVRIWVMDEKTILKNVIKPRQQGGLRAVPITCRYSRDGLLVATACQDGSIQMWDHRKRYVNTCLLVQNAHERGTGTSSLAFSYNNRYVASRGGDDTLKLWDLRNFKQPVNIMGCLFNRFPMTDCNFSPDDSYVFTGVSLRKNETSGKLMFFNKDTFKLAYELEVGNSDVIRSMWHPKLNQVIASTKNGIVKVFYSPDFSERGAKLIVSKAKKKEKQNVMICEQQIITPHALPMFRVDRPKSTKKQMEKDRKDPLRSQRPDLPVTGPGQGGRIANAGSTLSSFIAQNLGLKRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TME0</accession>
    <name>A0AAV6TME0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_009836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002031">
        <property type="protein sequence ID" value="KAG8173142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TME0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8173142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="117" mass="13581" checksum="F4DC12856F442E6C" modified="2024-11-27" version="1">MKKCRKPETRKGLYTAFQSRCSKENYPLLQEIVQMRHKLANMLGYPNHASYETELLMSKSAETVSTFLSELLEKLRPMWAKEKEYISARIEGKRCKELGIPFDGKMNPYMTLPSTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMH2</accession>
    <name>A0AAV6TMH2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_023920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002284">
        <property type="protein sequence ID" value="KAG8172881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMH2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.420.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.470">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058626">
        <property type="entry name" value="MdtA-like_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058625">
        <property type="entry name" value="MdtA-like_BSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058627">
        <property type="entry name" value="MdtA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058624">
        <property type="entry name" value="MdtA-like_HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30158">
        <property type="entry name" value="ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30158:SF10">
        <property type="entry name" value="CATION EFFLUX PUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25944">
        <property type="entry name" value="Beta-barrel_RND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25917">
        <property type="entry name" value="BSH_RND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25876">
        <property type="entry name" value="HH_MFP_RND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25967">
        <property type="entry name" value="RND-MFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111369">
        <property type="entry name" value="HlyD-like secretion proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multidrug resistance protein MdtA-like barrel-sandwich hybrid" evidence="3">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Multidrug resistance protein MdtA-like alpha-helical hairpin" evidence="2">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Multidrug resistance protein MdtA-like beta-barrel" evidence="4">
        <location>
            <begin position="130"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Multidrug resistance protein MdtA-like C-terminal permuted SH3" evidence="5">
        <location>
            <begin position="217"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8172881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33437" checksum="FB812F62801FB47F" modified="2024-11-27" version="1">MEGQFVQKGDLLLVIDPRPYQASLDKAKAEYFQTFTQLKLAEDTLQRYAKLAEQDYISQLNYDQYMANFLEQKAVVGQSVADLENAKINLKYCYIHSPIDAITGKLQFKPGNYIDTNQDTTLTLLNQIDPILVDFSVPESDLFTIQKCSQKSFLKLYIFPTLEHTTCFEGQLTLIDNQINTATGAILLEGTLDNHDHLLWPGHFVDVRLVLEEKESLILPSEAIGVGQKGHYVYTINQNMEVETTPIIIGQRYENGTTSIESGISTNDIVIAQGLLDLYPGKKVHIQTWLNNKEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TS08</accession>
    <name>A0AAV6TS08_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001251">
        <property type="protein sequence ID" value="KAG8174333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TS08"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="158" mass="18086" checksum="B36E57605E4ABD85" modified="2024-11-27" version="1">MAVAYLSFFIERCLNQTTIRRLRIPLEDFFQCRIVGDGTDRSCNIENAQIGSFYTKEKGTPSFCYTIFSHWGNPGAEIEKIKRSEKIEIETYIDYSYQNKSAPIDLVQLPKHNGVTNPALQLAIHSRYLTVSPYAVGNGFFGGKHYTITLKQVCFLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TS29</accession>
    <name>A0AAV6TS29_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_024381</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001233">
        <property type="protein sequence ID" value="KAG8174377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TS29"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF76">
        <property type="entry name" value="NEUROPEPTIDE SIFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8174377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="268" mass="30255" checksum="42A6CD33AAA67ACB" modified="2024-11-27" version="1">MVLMVVVAFAVSWTPYFVVSLVTQWAQVNFLEEGHFFFTMLNLNLLAFLNSCVNPFIYAAMSARFRNGFLRYYGHSPTPSAQQNLLAAPESFGNGRDFLTLSDTRLYFTSRCFRLFCCFCMPVVEQKTTGQTDTRTRRVRFRCEPTCLIQSSSDGCSNVENNASLKTIVTPDNQKRSILKNHTRGSQGSFIAHYIKKNEKIIFNRKDPSAKDIPNIVKHAISNDIEERLKYLDGGRPLFAKCQLITTSSSIGLGSDCSEDKEISNTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TT54</accession>
    <name>A0AAV6TT54_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acidic leucine-rich nuclear phosphoprotein 32 family member A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_012610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ANP32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001047">
        <property type="protein sequence ID" value="KAG8175242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TT54"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000003">
        <property type="entry name" value="Acidic leucine-rich nuclear phosphoprotein 32 family member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF0">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8175242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="243" mass="27760" checksum="AFB18CC400911886" modified="2024-11-27" version="1">MEKRIELEKRGRLPSVIKELNLDNCRSTQIVGLTEEFVNLESLSLINVGLISLKGFPKLPNLKKLELSDNRISGCLNWLHGSPKLTHLNLSGNKIKDINTLKPLEEFKNLKNLDLFNCEVTNVENYRSEVFALIASLKFLDGYDREDREAEDSEADDDDANEEDSDGNEVHEDGDSEAEFDEDGEDEVEDELNVDDEEEDDDLDDEDADEEDDSEEGNEEEVDEEEESTRGQKRKRDAEEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TU92</accession>
    <name>A0AAV6TU92_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001051">
        <property type="protein sequence ID" value="KAG8175161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TU92"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="217" mass="24303" checksum="A724E1D911680113" modified="2024-11-27" version="1">MDTGVKASGFWDRIPVVGPVSLDRAIILQERSRRVIRRYDGEETTYFALIDPTMLPESAQDSTLGNSIEVVRMLFERLLVQTTRNLSPHDLIRIILEDDTLDRPISTFIMKVSDMSVDAIMNAVTKVLQSKDEIKLDAGFSVNVSIIRRPRGGGRNRRMVNPEVDRLKKGSVLTIPKDDSGLCCSSAILLGLAVHNTDPELRTLKNQSCDLLKRRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUL3</accession>
    <name>A0AAV6TUL3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001028">
        <property type="protein sequence ID" value="KAG8175333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUL3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="412" mass="47042" checksum="83E1515C314FF5EC" modified="2024-11-27" version="1">MQDYIEKNQVEVVLDETHKEEHLYYLPHHAVKKVSNGETEWRIVFDASSLSPGHPSLNDALETGPNLLPGILAPLLRFRLSKIAITSDRSQAFLQLILADEDKEATRFLWYKTTSTPDGKLCIEDEIVSYRFTRLPFGLASSPFLLSASLRELATMYKQTYPTATKHIENNTYMDDFVLGTSTDTEATILYQEMQQLTSRVKWDTDSDVFQIDVLAKIVEASREPVTKRILLKLMSKFYDPLGLLAPVAVVVKILFQDTWLSGIQWDELLPPAVAQQWHKWINELQCLNDIRIPRWIGFSENSDTTIHVFYDASERAYGACLYSRQTVDSSTSVSLICSRNKLAPIKKVTLPRLELLAALLGARLLQYFCKETNMNSYTAILWSDSTVALSWIKGDPNRWKTFVCNRTTEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVX6</accession>
    <name>A0AAV6TVX6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000918">
        <property type="protein sequence ID" value="KAG8176110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVX6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="181" mass="20417" checksum="98EF0A00404F69A6" modified="2024-11-27" version="1">MAESNEKPTITEELKALREQLKEVQEARIQQYEARICQYEKQIETDGVWRTDMAMELKAVRTQLQEAHQECVHYYQTRVSELQNEMLQRRGGDDAALPKVLAQENEMTKHPGYRCRCCGFTECGSCYDNVPFTSSSSDDDVDYMGSDSGVDDEGVVAPWTTAIITSDLLGCSPLAYPLKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWM4</accession>
    <name>A0AAV6TWM4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000950">
        <property type="protein sequence ID" value="KAG8175756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWM4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27716" checksum="F12AFCCA930BB08D" modified="2024-11-27" version="1">MEVQCISKHSKIPMGTEDTYAWTQTFEVLLGYVSSRIGKRDTVLRKAIPAAARLALTIRFLATGETQTSLHFQFRMGISTICGILMEVCTAIFSTMRADVIPTPSTEEEWREISTNRFRLFQTTIYGTPAKVKAYVLAACCLHNFLRMRILEREGMDAIQGEQLMTETEYSEWQQEAIAFVPLQRGNWRGNQQAKLVRHKFKSFSTRLVLLNFRNGNATFIKVYYCLPGNCFYTIPKMMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWW2</accession>
    <name>A0AAV6TWW2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_022456</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000900">
        <property type="protein sequence ID" value="KAG8176284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWW2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="169"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8176284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="368" mass="41353" checksum="22B092EF551EBBF9" modified="2024-11-27" version="1">MGHKGILESISSSEWATPVVPVVKRDGSIRLCGDYRCTVNKSVKPYTYPLPTVNEVLSTVAGGKVFSKLDLSQAYLQLPVDDATSRLLTLNTHKGLFRVKRLPFVELQAFLGLLNFYGSFLKRRSDILEPLHKLLQKDVPWEWTAEHEEAYKASKGLLTTDDLLVHYDEKLPLILTSDASSYGLGSVLSHLLPNGKEAPVAYYSRTMTKTERNYSQTDKEALAILAGVKKFHSYLLGRRFKIVTDHRPLLGIFNSTKPIPQMISPRVLRWSLSLQAYDYELEYRKGKDIANADALSRLPVSTPEFDVPQPADILLLESDTQFQVDSKLLAVSTKRDPVLSRTALWVSNGWLIIPQMSGSSLILREDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXF8</accession>
    <name>A0AAV6TXF8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000938">
        <property type="protein sequence ID" value="KAG8175940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXF8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25644" checksum="3E61A93C773B7CD5" modified="2024-11-27" version="1">MTRSSHRTTAPKICRTIKESLRACWTQELIAQAQPRTQTLLACLRALCAGSPETSIACLCVRLRERFFSSPKELQSLLDLLPSLTLQLGLAINTSKCSTIHLSDVTPRGHRLTPFFLNSQQLEVIPDHVPSSFLDTPIGFQLFQNTEEIEKILDLGKKIGESCLAHWQRLDAFKSFFFLALNFPMKTGQFSKDQLRQVDNEVRKFLKVTLNLVGPAVGGLQPLHLRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZ39</accession>
    <name>A0AAV6TZ39_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UFSP1/2/DUB catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_015591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C78 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000814">
        <property type="protein sequence ID" value="KAG8177143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZ39"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071567">
        <property type="term" value="F:deUFMylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF3">
        <property type="entry name" value="INACTIVE UFM1-SPECIFIC PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="3">
        <location>
            <begin position="21"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8177143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="214" mass="24614" checksum="CD7B1B90CB623468" modified="2024-11-27" version="1">MNLEEDIHNNLPFPSKLKKYALVRGSYLYYHYKCDGVNDAGWGCAYRTLQTICSWIVKQENIKYLVEIPSINDIQTALVKVGDKPESFINSRQWIGSLEISYCIDYFYKILCRILHCKDVKEVQSHTSSIFNHFQEYGSPIMMGGDRDCSSKGILGICETEIGMHLLILDPHCRGPTVSKENLQCEGWIKWLKIDDLDHSSFYNLCYPLLKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZT0</accession>
    <name>A0AAV6TZT0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000793">
        <property type="protein sequence ID" value="KAG8177276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZT0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="108" mass="12371" checksum="1618A4E5138F7AA8" modified="2024-11-27" version="1">MWHPCPSSLTLCPLTTAGGHPTSGVDELKKLFWSSHQHTLERHGGLFLSEPEAKFAKCMGQTTHRAMTREDIGTTWGRLIGNFSKEKVLLGDRQLLKEEIRNWFFYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0F5</accession>
    <name>A0AAV6U0F5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000783">
        <property type="protein sequence ID" value="KAG8177388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0F5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="143" mass="16384" checksum="24F6B252C1D921D9" modified="2024-11-27" version="1">MHVYWGQSVHLSCAIHMPDVESMGLGPLRWFHYSREKGKYAVLHRREKFIHTADHGLVVLAVGERDAGRYDCKLGASTLCSFNITVDTKTCSAPTEAEYRKVYSDWCHEFEKYKLAMKSWQNKQAKCQSVHPNDVTYQGATLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1V8</accession>
    <name>A0AAV6U1V8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_000801</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000734">
        <property type="protein sequence ID" value="KAG8177938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1V8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000010">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="17">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8177938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="9012" checksum="1C9B7B8A9FC0B054" modified="2024-11-27" version="1">MSRKQTPSEFLKQIIGRPVAVKLNSGVDYRGVLACLDGYMNIALEQTEEYVNSQLKNKYGDAFIRGNNVLYISTQKRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1W6</accession>
    <name>A0AAV6U1W6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">cAMP-dependent protein kinase type II regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_014707</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000732">
        <property type="protein sequence ID" value="KAG8177964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1W6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12099">
        <property type="entry name" value="DD_RII_PKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000017">
        <property type="entry name" value="cAMP-dependent protein kinase type II regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000108">
        <property type="entry name" value="cAMP-dependent protein kinase type II regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0114">cAMP</keyword>
    <keyword evidence="3 8" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="130"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="253"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8177964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="392" mass="44752" checksum="5A9101A7BB57E58B" modified="2024-11-27" version="1">MNRPRLEVPRELTSLLLDFTVNVLLEKPADLVDYAVNYFTKLREDGRSNNIVEPTTEVPSVTCEEDNLSDEDDEPPPVRKSQNQYSRRKSVFAEQYNPEDDEDDDVERLIYPKSDDQRQRLGEAVRNILLFRSLDLQQMQEVLDAMFERKVVPGDVVIQQGDDGDNFYVIDNGVYHIYVDTDQEKKKLVGKYDNVGSFGELALMYNMPRAATIEAASDGSLWAMNRQTFRRIVLKSAFKKRKEYEALLEGVPMLQTLENYERMNLCDALMPKAFSDGELIIKQGEDADGMYFIEDGNVKITMIKETEDNKEVEMEVITLPKGQYFGELALVTQKPRAASAYAVGNVKLAFLDVAAFERLLGPCMAIMSRNVDHYQKQVVELFGSEANISDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3Y9</accession>
    <name>A0AAV6U3Y9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000703">
        <property type="protein sequence ID" value="KAG8178314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3Y9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="8963" checksum="1DD51CEDABB0147E" modified="2024-11-27" version="1">MFSPMSLSCPISKPKGEAFNYYTCQLGLPPVSSYPHHLFTTSTAPSTFAPSPLKSSLPTPLSPSPTQEMSGDKAARKIALSFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4K6</accession>
    <name>A0AAV6U4K6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_016048</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000652">
        <property type="protein sequence ID" value="KAG8179039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4K6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15041">
        <property type="entry name" value="7tmB1_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF15">
        <property type="entry name" value="DIURETIC HORMONE 44 RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="12">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="13">
        <location>
            <begin position="102"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8179039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="402" mass="43964" checksum="FD48978E1A3C62D6" modified="2024-11-27" version="1">MAAAVDSEEECLLKYASQSPGWCPAAWDSLVCWPPAPSGDTLAYPCATLFPHLANDTVSVAFRTCSEDGQWSQNGWTNYSQCMQLDLQLQEEATPFVSPFSVSVVILVGSLISLVCLGAAVIIFTAFRSLYCCRIRVHRCLVLSLALHALFMVVVACAGLSPTLLSILDTTAWLCRGLVCIKCYASLSSVLWMFVEGLLLHASVASSVFEPQPYSFTLMHAIGWGIPGVCVVVWACLMWAYFESTSCWRGYGRSPLVWIVTGPMMAALTVNAVFLVNIIRILVTKMRSNVAIETKQIIKAARATALLFPLLGITHLLFCVNPGGDFEPLYMLTNAILQSSQGLFVAVLYCFLNSEVQSAVSAAYSRRRSSAWSVVRSGRSFRTYANSVTSGRHEEIALRDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U598</accession>
    <name>A0AAV6U598_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000651">
        <property type="protein sequence ID" value="KAG8179058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U598"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23698" checksum="752AF010A5E81FE7" modified="2024-11-27" version="1">MTLYDYTLQDYCLSAIAPRLRSVTQRYALPLPPSLQRKLFYAFDNSRSAKYQETLLAPPSWLDPAQPESCWKAARLLYLISLNWKKVNTLPRDVYAFFMQCDTSPATYLGFARKYHVVTECYVKTCHALPIVRLCHACCAREKTQPRFRDRMEGKSTFELERRHDTFYQKDPLLMAALKDTSVSWCAHCVTTPLFRVYRSVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U630</accession>
    <name>A0AAV6U630_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_026324</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000627">
        <property type="protein sequence ID" value="KAG8179425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043775810" evidence="4">
        <location>
            <begin position="22"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1428"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="5">
        <location>
            <begin position="1220"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1340"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1391"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="926"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="1417"/>
            <end position="1426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8179425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1576" mass="175843" checksum="90AC62D3E42357C3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U882</accession>
    <name>A0AAV6U882_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_020471</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000579">
        <property type="protein sequence ID" value="KAG8180175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U882"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002178">
        <property type="term" value="C:palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="7">
        <location>
            <begin position="19"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8180175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="142" mass="16279" checksum="9C612973190BC297" modified="2024-11-27" version="1">MAASVNRPSAENREKVQKIFIQRDYSEGTNVKFQTKFPAELDGLIDRHLFEQTINTLNRIYAEAEKTSATTFCESCLACLTSYVIYLCIETHYQKCLKRIAAYLEDQNETVWLPRGLLITDPIERGLRVIEISVLVDPSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U895</accession>
    <name>A0AAV6U895_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_023675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000588">
        <property type="protein sequence ID" value="KAG8180058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U895"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47048">
        <property type="entry name" value="PROTEIN SCAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47048:SF1">
        <property type="entry name" value="PROTEIN SCAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8180058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8416" checksum="8C49E45A554081DF" modified="2024-11-27" version="1">MSNTCPICFEDLVKKNRATPDICDHIFCFPCLEKWSKHGSYCPVDRKRFRRIVNLDSETVIQGTWKVILKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8A8</accession>
    <name>A0AAV6U8A8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000569">
        <property type="protein sequence ID" value="KAG8180304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8A8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="10779" checksum="4E93CD9D834945AE" modified="2024-11-27" version="1">MVIPGTPFPIQEQSVIPQQVPNTPRRSSWPLEGRCSSWLLTFLVRAPVTPHHRRPVAFVRPCHATDVLLGIFFLVRCLVLSFGKDVQVRCFDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8B4</accession>
    <name>A0AAV6U8B4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000586">
        <property type="protein sequence ID" value="KAG8180078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8B4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="189" mass="21594" checksum="217A5BF33993C0DD" modified="2024-11-27" version="1">MESSSEQPELPKSPCLIAKAVLLVFSMLIATFGLFFFAFHLHYWAVYSSLMLGEYHSSPVVCTLYIHQVYLATKEKLLETYSFRAIYILCFFVGKILAYSTVGFVAVGMAKHQRFSFNDGFYVAAIPSSIACCWAFLLAYESNRHMKKVTPPDDEEFHHIIELPLPTNENTKYDVHFHVTRTNPPSGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9T0</accession>
    <name>A0AAV6U9T0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_018226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000559">
        <property type="protein sequence ID" value="KAG8180608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9T0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF7">
        <property type="entry name" value="SI:DKEY-228B2.6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8180608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="246" mass="28646" checksum="60738D661017CE75" modified="2024-11-27" version="1">MVSSCCAFGCTKRYKKGDNIGFFRFPLKNKSRLDKWLKALRRTNWTPTSASKICGQHFQSGKPNSDENHPDFVPNIFMFAKPSTSLMSFNRRQKVLKKRSVIAETSVIQEDRTEAENDAADALLLFPSKVCEQEQPLSDKELIKKLYREIDYLRDEVKDLKQQVELLKNEEDPGVDMLSSPKKVSFYTGLPSSELFQIVDLRSKICLRNVERNLLCRHLQEGKNNCPNLRFCSPLEYRMFEFTWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UA41</accession>
    <name>A0AAV6UA41_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_015805</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000544">
        <property type="protein sequence ID" value="KAG8180880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UA41"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04115">
        <property type="entry name" value="Rab33B_Rab33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002685">
        <property type="entry name" value="RAB33A, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041822">
        <property type="entry name" value="Rab33A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043899515" evidence="8">
        <location>
            <begin position="22"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8180880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="234" mass="26472" checksum="38EF715AFDD42124" modified="2024-11-27" version="1">MMISQLILLSLKVTMSNLTESVSFEKQKKIFKIIVIGDSFVGKTCLTFRFCSGKFPTKTEATIGVDFRERSVNIDGETFKLQLWDTAGQERFRKSMIPHYYRNVHAVVFVYDVTKIQSFENLSHWISEFKHYQGTSPDIPKILVGNKSDCAHLKAVNTNMAQKFADSHDMPLFETSASDEGEANHVEAIFMTLAHKLKNHKPMMPSSLSPSYADTSVIQLKPDDSKADDKCCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAT9</accession>
    <name>A0AAV6UAT9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000515">
        <property type="protein sequence ID" value="KAG8181440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAT9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="142" mass="16685" checksum="DD6E9B966DBBE6B6" modified="2024-11-27" version="1">MKKSGSSLQLSLTPCHTSNNDHWCDLSTGLPRPFVPEQFRRQIFEHLHNISHPDVAATTKLICKQYAWPHMKKTIKLWVQTCEQCQRSMTSAIPRRYWGHLRYLMPVSPNSTLIWCALFHHPTIHLYPHLYPHDDRPLHQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBD5</accession>
    <name>A0AAV6UBD5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000503">
        <property type="protein sequence ID" value="KAG8181650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBD5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037189">
        <property type="entry name" value="HBS1-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109732">
        <property type="entry name" value="HBS1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="621"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="896" mass="100964" checksum="8D39A4524AC4263F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCZ0</accession>
    <name>A0AAV6UCZ0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_003160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25325"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:25326"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:25322"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoethanolamine + S-adenosyl-L-methionine = N-methylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20365"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58190"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:20366"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000535">
        <property type="protein sequence ID" value="KAG8181111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCZ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000234">
        <property type="term" value="F:phosphoethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307:SF2">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="55"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8181111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="132" mass="15308" checksum="F542B5DB54340D1C" modified="2024-11-27" version="1">MNVSSYGTRVRMLEYWAKFAPSLESMMLDKTAGQMHLDEQEEIFSLLPSLRNKRVLELGAGIGRYTGLLASEAYRVTAVDFMEEYINVNEQNNKRASNITYIAADVLDLQMPNKKQVESFCKFNFNYRVIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UD14</accession>
    <name>A0AAV6UD14_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_020449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000481">
        <property type="protein sequence ID" value="KAG8182089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UD14"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="129"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8182089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="442" mass="50625" checksum="8393E8AC6B233C8C" modified="2024-11-27" version="1">MATFNGLHLRIAYSDLEPFVIILDNVTLVLSGIMPDIVYNVARSMNISLTYIREPEDKYGTLENGTYSGMLGMLHRNEVDIIMNPILPDETLLDFAYLTNPITAEAYTMLSGKKSQDAGFFLYFSVLDATVWYAIVIAAVATTIASAFMFNNLRMKEKKWRRNSPGSSCTELCIEYFWVFLSYMLQQSPSEKYLLRNSKTKSSYLIQLMVVLWVIGVAFLVMNTFRSLLVSKLTLRKTAPYIDKLEDLLDTDETKGIAPVEIYIEDALENSGIDLYDMVWLKIKHNLWPGEEVFKDETIEDVQNGKFCIFHGHLILENRLSEFYSQNSYCNLHLSKNYFFPFPLVMALQKKLPLSFREDFNFRVTRSVDADIPGKYLKSALEISKLCTSYADNSLEPLGLKNIYGVLILWFAGIICAALVLFCERIYKHSCRDCCLPMDFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDC0</accession>
    <name>A0AAV6UDC0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_000063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000475">
        <property type="protein sequence ID" value="KAG8182209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDC0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="660"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8182209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1034" mass="118189" checksum="BF031A57E1F2DD42" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEA5</accession>
    <name>A0AAV6UEA5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_026173</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000451">
        <property type="protein sequence ID" value="KAG8182722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEA5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000009">
        <property type="entry name" value="Isoleucyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000111">
        <property type="entry name" value="Mitochondrial isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="67"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="726"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8182722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="922" mass="105747" checksum="2792FD23FB22D449" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEJ2</accession>
    <name>A0AAV6UEJ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_017009</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nudE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000503">
        <property type="protein sequence ID" value="KAG8181651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEJ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007100">
        <property type="term" value="P:mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="10">
        <location>
            <begin position="153"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="289"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="41"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8181651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="324" mass="37315" checksum="29A101FF0D94AE3B" modified="2024-11-27" version="1">MLLCKWKVYLFVTKIIGAAMQAQNLSFSSVEEERDYYKDLANEYEQKYQETKLELEEFQDSSRELEAELEAQLEQTEARNRELKSLSGRLQIECDSLKDKLQKLQHDSHTQISDLEDELGRVTATRDDLQKYIRELEQLNDDLERAKRAAVSSLEDFESRLNQAIERNAFLESELDEKEMLKVTVQRLKDESRDLRQEMVVHHRPVLEKSLSVDTKSDHVKTIVDSNKIKSELENQPEIPVKRLSCHQLNSSTPFTPSSRISALNIVGDLLRKVGALESKLASCRAYVKENSPKPEKEDAEKQSPIQSKRLISKSSQDCISLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFI5</accession>
    <name>A0AAV6UFI5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000444">
        <property type="protein sequence ID" value="KAG8182856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFI5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="7745" checksum="63E20E0F7BB41B3D" modified="2024-11-27" version="1">MDHFFDVSDRAMYSASVVDKATVRCFLASHIMAPPACLQINPVKLLLSDVQEAKFASANAVSGSPVFVNSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGD2</accession>
    <name>A0AAV6UGD2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_004254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000442">
        <property type="protein sequence ID" value="KAG8182888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGD2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000033">
        <property type="entry name" value="Polycomb group RING finger protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032443">
        <property type="entry name" value="RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825:SF29">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8182888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="503" mass="56731" checksum="6DEC8E0805B8586A" modified="2024-11-27" version="1">MQSPGKTKLVELNELLTCILCKGYFIDATTISECLHSFCRTCIVRYLQDNKFCPSCEVQVHKTKPLQNIRSDQTLQDIVYKLVPDLFKNEMKRRRDFYQQQDDLVLESIPSSSEKRGDVWGCDRLIFTPDDVISVSLEYSPLNEQLPVNFQANAYNLEKEKLTQYPKRYFNCPGALKVFHLKKLLQAKYGLIGSKKKVEVLYMHDLLKDQYTLVDLAYIYSWKRSEPLRLFFKITQEPPLKVSSELPENPLPSLPPCLPPKISSSMAAAPSSRHPSPPPSPQMAQEPNDVANQGANVPSKGSATLQSAKFQDASLLEPKELSGSVPTPIKGEQGSKMIPLGFEISATQGNGHKDKIEKAMVSELSSPKRINEVLAERIVSEANSNIDSRIKSCTIPLRSFEADFPPGCNFTDIATLPQLKSALKKTANFVDADRRFSDSQMLNLDVTKRRKSKKRVSFSVNLVQGEKRKSSDFFDEEATLEFDPVKKSEMIHLRKKVLSNKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHY6</accession>
    <name>A0AAV6UHY6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000400">
        <property type="protein sequence ID" value="KAG8183882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHY6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="221"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="378" mass="43320" checksum="C74F569BFBAB1CEA" modified="2024-11-27" version="1">MKKDYKYEMSLLTSSGEIKLGQELCDDLNRYCCFYKIEKNKIFGETSDSFLLQGALTLCCRIWQQKLKPGLCFLRTALHEVNFSWIIEGFSLDSDSIKRSLHEQEKFLLDTILYKYTTEEGTHRVRIELLPYYGKWSTFIRCHIDIGDESGNVISSNCTRPVVSWNWDVAIHSEECPDGHLRLEFKSLIAVEHPTPPDAAVGSSSTLSRDLLQLYRKKTFSDVTLNTDEDTSLSAHKNILAARSCVFEAMFEKDQTVEGRSGVVDIDDVDSETMDRLLVYLYSDSLEVELWWEQASALYYAADKYAILPLKQECAQVLMVAMTADNVCDVLVLADRHADEPLMSCAVDFLRYNQEVFSSPAWENLEKSNSINHLRFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI61</accession>
    <name>A0AAV6UI61_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-latrotoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_005188</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Homotetramer in membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cationic peptide 01 (latrotoxin) family. 03 (alpha-latrotoxin) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000395">
        <property type="protein sequence ID" value="KAG8183957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UI61"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03716">
        <property type="entry name" value="SOCS_ASB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="12" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="17">
        <location>
            <begin position="426"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8183957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="468" mass="51706" checksum="284A3E725A1A3665" modified="2024-11-27" version="1">MPSIACLQTLQRELADSIIRCAPLDDIRILLACGAKVNEPVTQGLRPIHYAAFQQYVEALNLLLVRGCDPDAMDEIGYTALHLCAERGYIDLVELLLEHKARVSFTELDLEDTALGNPPRATIADEPLRLAIKNGHYQVAEVLLKNGADPNARYFLGSEINLISPLNTKFLGLLLKYGADPNSKDRTGLTPLMKACRHPQGLLSAQILIKYGADVNAMTPERHDNRTVLHYAVLSGNLDTVKLLLKHGAVVKFSSDYMKPSPLDFSILRGNPEMAKLLIDSGADVNVGSPIIGCPLHIALSEKVDNKVEIIQMLLDCGADPNTVSVCDDGPLIKPPIGEYFNSCDHPTVDVVRLLLCYGARIVIKSQIHHPLGILKSVHRLHPESHPEVLDVVLDAAESYSAASINRSLLLTDQQRQVLLEHALTPPPLKHLLRVFIRNTFGFGPPVIKRIQHLPLPWLVKKFLMYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIQ4</accession>
    <name>A0AAV6UIQ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_028047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the villin/gelsolin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000410">
        <property type="protein sequence ID" value="KAG8183683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIQ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF45">
        <property type="entry name" value="SUPERVILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HP" evidence="3">
        <location>
            <begin position="967"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8183683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1030" mass="118358" checksum="DA9ADC750ADA376B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKC6</accession>
    <name>A0AAV6UKC6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000368">
        <property type="protein sequence ID" value="KAG8184600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKC6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="10827" checksum="E26DE3101AC4D70D" modified="2024-11-27" version="1">MTLPKTVEPISSPSNAIFSQTSSCELEVFLLHFRLVLDQFCGHFGGKKDRFRRREMRRVRGVPCSALSPEVPVKPEEAQTRILLRNKKGHRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKJ2</accession>
    <name>A0AAV6UKJ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000377">
        <property type="protein sequence ID" value="KAG8184323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKJ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="158" mass="18156" checksum="9BDD4257499EDEB6" modified="2024-11-27" version="1">MGRVRRALNSFFLSGDCWRFPKYQPMPEPKYKPNAIKDLFWAYDTNVATRDCFKRSVSSLPQMSRGRRRAQKVVLSLPPFRGEGVHVPREGEGGGLPGWSASRHLGGLGPPSTLLSWRQDSKEIAHLAEWRYICPHFYQSFFFIHEGGILVHETCEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKV9</accession>
    <name>A0AAV6UKV9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear cap-binding protein subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_016202</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NCBP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000357">
        <property type="protein sequence ID" value="KAG8184857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKV9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Chromatin target of PRMT1 protein C-terminal" evidence="5">
        <location>
            <begin position="461"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8184857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="618" mass="70644" checksum="27CA68AECBE0104B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UL80</accession>
    <name>A0AAV6UL80_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NFX1-type zinc finger-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_017065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000349">
        <property type="protein sequence ID" value="KAG8185044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000742">
        <property type="entry name" value="NFX1-type zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNFX1" evidence="4">
        <location>
            <begin position="507"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="702"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="3">
        <location>
            <begin position="1133"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8185044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1979" mass="227257" checksum="535DF00F44B056C2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UM71</accession>
    <name>A0AAV6UM71_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_004922</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transglutaminase-like superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000359">
        <property type="protein sequence ID" value="KAG8184824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UM71"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09443">
        <property type="entry name" value="LIM_Ltd-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000108">
        <property type="entry name" value="LIM domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053041">
        <property type="entry name" value="Transglut-like_Superfamily_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020:SF1">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8184824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="805" mass="92807" checksum="10236F4F118E33E4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMD9</accession>
    <name>A0AAV6UMD9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_019723</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000334">
        <property type="protein sequence ID" value="KAG8185464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMD9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903313">
        <property type="term" value="P:positive regulation of mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.230:FF:000001">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="14">
        <location>
            <begin position="98"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="12">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="12">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="12">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="987"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="987"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1010"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8185464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1115" mass="125019" checksum="03B90A568C225B80" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPM7</accession>
    <name>A0AAV6UPM7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000311">
        <property type="protein sequence ID" value="KAG8186145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPM7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="8382" checksum="6E07CFE034B8EA36" modified="2024-11-27" version="1">MWSGCCVGQIEEYLKNRWRRLDSNDSTCLCQKNIPWSSPNSFHLEQGRTFSNDCKQCENKGLSRDQLWCCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTB1</accession>
    <name>A0AAV6UTB1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_000188</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000262">
        <property type="protein sequence ID" value="KAG8187725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTB1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000017">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8187725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8687" checksum="8109D3A89DDD9A00" modified="2024-11-27" version="1">MSKAQPPELKRYMDKKLHLKLNGGRHVVGVLRGFDPFMNLVMDEAVEQVKEGENNPIGMIVIRGNSIVLLEAMERVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUB1</accession>
    <name>A0AAV6UUB1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000287">
        <property type="protein sequence ID" value="KAG8186841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUB1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="96" mass="10706" checksum="21C107CC5870B541" modified="2024-11-27" version="1">MDYSYLFVPQGRKKKVGDQNFFPHKNSDANAFVPFHAFLRARILSYCSRNISVGDEAALEISSSGFGDSGQVVRLLLMSSRAQALTRLRPCPHLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVI8</accession>
    <name>A0AAV6UVI8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVI8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="8063" checksum="B87A3CF5D3B723BF" modified="2024-11-27" version="1">MVSTAHVPYGTGVGYLLTPGAGYGGLGYSGAGLGYGGLSYAGAGLGYAGAGLGYAGLGASGLGYAGLGGLGYGGYGLGGLGYARYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWJ0</accession>
    <name>A0AAV6UWJ0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWJ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8188479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="43351" checksum="AB15726DB7D4781A" modified="2024-11-27" version="1">MAVVGYSRAAGNYKGSTSGYGQGGTGGNGGYGSGGSGGGGGYGQGGTGGTGGYGSGGTGGTGGYGSGGTGGTGGYGSGGTGGSGGFGSGGGTTGPGRNTAGGFGDSGRNTGTGGGYGGDNSGTGRNTGTGGGEYGGDSGGTGRNTGGGYGGRNTGGGYGSGGTGGGGGYGSGGPGGSGGLGSGGGGGGGGSGGFGRGGGGGGGGGGGGTIGGRGGSGGTGRNRGISGNGGTGRIGGIGGNAGIGNNGGVNSGGYGGGRTGGGEGDGGSRGSGGGSNGYDQNQNNGPSEPYKFDYQITDDDGNTNYRNEESDGQGTVRGSYGYTDNQGLYRIVDYIADANGFRANVRTNEPGTDAKNPSDVQMTVEDPPPGIQDRYSGSGDGFGGGIRRGGGVRTGGSGFGGGSGGNQGGGGNSGYGNQGGGNSVFGNQGGRGGNSGFGNQGGGGSSNFGNRGGFTAAASNNGFSRRRAGQRLGKSWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYK0</accession>
    <name>A0AAV6UYK0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_008469</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with the U2AF small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000213">
        <property type="protein sequence ID" value="KAG8189507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYK0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000074">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="138"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="248"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="355"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8189507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="458" mass="51204" checksum="766802CD35393075" modified="2024-11-27" version="1">MRGEKNTVTSALIKGDDKDKDWDRDRRRDRRRSRSGSRGRSGKKRSSRSRSRERKARSRSRERRAGGAAAGRNEVRQPRRRKKSLYWDVPAPGFEHISTQQYKDMQSSGQIPPSIYTTQGPVVGTVPVVGSTVTRQARRLYVGNIPFGCSEDEMMDFFNAQMHVCGFSQAQGNPILACQINLDKNFAFLEFRSIDETTQAMAFDGINFKGQSLKIRRPHDYQPVPGMSEIPNSAVPGVVSTVVQDSPNKVFIGGLPNFLNEDQVKDFLLSFGQLKAFNLVKDTATGLSKGYAFCEYVDTVSTDQAIQGLNGMQLSDKRLIVQRASVGAKNVQTNVPVQVQVPGMQVAQGPGPATEILCLMNMVVPEELMDEEEYEDILEDIREECTKYGTVKSVEIPRPIEGVDVPGCGKVFVEFNSIIDCQKAQQSLTGRKFANRVVVTSYFDPDRYHRRDFGMSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V022</accession>
    <name>A0AAV6V022_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000216">
        <property type="protein sequence ID" value="KAG8189413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V022"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8695" checksum="EA65827333BEBB32" modified="2024-11-27" version="1">MKLIPHKNVTVHDKLPSTRYTTKLPFRFRNVNKFLKKVPQKKDTKGGYPNCFLDRVQAHIVPRHRVDPERTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1M9</accession>
    <name>A0AAV6V1M9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="20">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">JTE90_022027</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:18106"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Mn(2+)(in) + ATP + H2O = Mn(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:66821"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Sarcoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="20"/>
    <dbReference type="EMBL" id="JAFNEN010000185">
        <property type="protein sequence ID" value="KAG8190384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1M9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02085">
        <property type="entry name" value="P-type_ATPase_SPCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000008">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000006">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000106">
        <property type="entry name" value="E1-E2 ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006413">
        <property type="entry name" value="P-type_ATPase_IIA_PMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01522">
        <property type="entry name" value="ATPase-IIA2_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 20" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="16 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="805"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="873"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="903"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="59"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG8190384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="947" mass="104121" checksum="CA33FF46480351E4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3Y5</accession>
    <name>A0AAV6V3Y5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_001296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000177">
        <property type="protein sequence ID" value="KAG8190688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3Y5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000029">
        <property type="entry name" value="Growth hormone-regulated TBC protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF10">
        <property type="entry name" value="GROWTH HORMONE-REGULATED TBC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="278"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="203"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8190688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="278" mass="31892" checksum="4464FD837374A9A2" modified="2024-11-27" version="1">MTHLEWCWFGGEEDNKAKVPQVHDLMVKTGVSWSMYVSKWFICLFAEVLPIETVLRIWDCLFYEGSKVLLRVAVTLVIKNQDKILAAKNFVEITEVFKSLPLGATVTECHTFMQAIFRVPGSFPRAHILRLREYCRGRVEQEQAHTKVLQEQQRQRAQEEKRLREERRIKEEEEKRIKEEEEKRIKEEEARLAAEEEENRGADELSPCDDAPQVNSSEGKENETEESKETDHVPNTTVISSSSSDSVKKVANGKQTSPIANENHSIAAAVESSPESYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V456</accession>
    <name>A0AAV6V456_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Msx2-interacting protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">SMART/HDAC1-associated repressor protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">SPEN homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">JTE90_020732</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM Spen family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000159">
        <property type="protein sequence ID" value="KAG8191485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12349">
        <property type="entry name" value="RRM2_SHARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12350">
        <property type="entry name" value="RRM3_SHARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21543">
        <property type="entry name" value="SPOC_SHARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000088">
        <property type="entry name" value="msx2-interacting protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000118">
        <property type="entry name" value="msx2-interacting protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000143">
        <property type="entry name" value="msx2-interacting protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Spen family transcriptional repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034173">
        <property type="entry name" value="SHARP_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034174">
        <property type="entry name" value="SHARP_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010912">
        <property type="entry name" value="SPOC_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50917">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="20">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="20">
        <location>
            <begin position="378"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="20">
        <location>
            <begin position="480"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="20">
        <location>
            <begin position="559"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="SPOC" evidence="21">
        <location>
            <begin position="5087"/>
            <end position="5256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
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            <end position="357"/>
        </location>
    </feature>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="3710"/>
            <end position="3719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="3761"/>
            <end position="3777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="3794"/>
            <end position="3812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="3874"/>
            <end position="3968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="4017"/>
            <end position="4036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="4067"/>
            <end position="4092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="4121"/>
            <end position="4147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="4149"/>
            <end position="4158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="4211"/>
            <end position="4241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="4408"/>
            <end position="4422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="4713"/>
            <end position="4724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="4837"/>
            <end position="4853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="4909"/>
            <end position="4923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG8191485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="5256" mass="588523" checksum="D193708B6E552CDD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V546</accession>
    <name>A0AAV6V546_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PiggyBac transposable element-derived protein 4 C-terminal zinc-ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000164">
        <property type="protein sequence ID" value="KAG8191198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V546"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="10271" checksum="06980E18741FF73D" modified="2024-11-27" version="1">MDLHFPIKSTRRRCTLCSRNRVQKRTSIQCSECKVALCSEKQNNCFQLYHQLICVYPWLQSRFVKPDKKHNDNDKPDKQCADVYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V804</accession>
    <name>A0AAV6V804_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000137">
        <property type="protein sequence ID" value="KAG8192607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="190" mass="20387" checksum="06C4304A38595E87" modified="2024-11-27" version="1">MSRYFAKEEKKNQEKRLLVFAKGRHYCRLEIGIARFCQAGAPASREEQGRDTPVTWTLPLNHAGTPVPEKCRRRDPPVSWNSPSNQAGAPASREEQGRDTSVSWTLSSFLAGTSSPAGAPGTHSSAIEGTRLRLWTPPSSPAGAPAPSKGLTITNVLVIALAPASTTTSLRGGTRHRTVPDISRKAGHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9S6</accession>
    <name>A0AAV6V9S6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000134">
        <property type="protein sequence ID" value="KAG8192863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9S6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8192" checksum="DAB9A2018EB21C19" modified="2024-11-27" version="1">MSDGGRPEEQDIEVLTRSIRNKACPIYIINACFTCRGSAYDHPAPKIPATAACETSLEDDPFSFGGKELETHTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9U7</accession>
    <name>A0AAV6V9U7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000124">
        <property type="protein sequence ID" value="KAG8193369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9U7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="85" mass="9173" checksum="1C0D7AF80820C72A" modified="2024-11-27" version="1">MSSEKDATSNTVPGIPDYRDVEVQVPMDIVPALMSLVTGLIVTSKSSNKGIQVKPKFKTRGTNPPKPPKHANVGFSTMEFDSVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBU1</accession>
    <name>A0AAV6VBU1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_009647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000122">
        <property type="protein sequence ID" value="KAG8193430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBU1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="95" mass="10600" checksum="EBDD2CD794AF8048" modified="2024-11-27" version="1">MDPDTKSFSCYAVSEALGETIVQTYTVAVVYPPSDPVITGYEKAKPVKAGDLQKFTCISTGGNPQATLKWFKNDKEVRFHCPNSLIRTVIIRRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCM1</accession>
    <name>A0AAV6VCM1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000103">
        <property type="protein sequence ID" value="KAG8194414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCM1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7441" checksum="3861A7A0ABF1FFD2" modified="2024-11-27" version="1">MNITANLNDSDKKSGTHPLTHVATIGRPPPDHAHTHSLPNDLGGNTPVYTPTQPHPSKGQIAETSYLVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFV4</accession>
    <name>A0AAV6VFV4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc transporter ZIP9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_001385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000089">
        <property type="protein sequence ID" value="KAG8195367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFV4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8195367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="32941" checksum="E4342E8C112C53A9" modified="2024-11-27" version="1">MGEVLVLLFLSSAMLIGCYMAGMIPLIVSLSEDKLQIVSVLGAGLLVGTALSVIIPEGVNTLYSSQIKQLEELRHMHKEAASTQETLVSPADMHGSMDFEPHSVIGVALVLGFIFMLLIDQISSNAQTHVRLPTTDIESPIKQDRQKITATIGLVVHAAADGIALGAAMTTSHTDIEMIVFMAIMLHKAPAAFGLVTFLMHEGLDRVRIRKHLLIFALAAPVMAIVTYFGISQSTKERLSSLNATGIAMLFSAGTFLYVATVHVLPEIALQSHHSGETDGKGFRKLELLALVVGALLPLLLSVGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VG30</accession>
    <name>A0AAV6VG30_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Complexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_029191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Positively regulates a late step in synaptic vesicle exocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complexin/synaphin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000097">
        <property type="protein sequence ID" value="KAG8194900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VG30"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.580:FF:000002">
        <property type="entry name" value="Complexin, isoform AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.580">
        <property type="entry name" value="Single Helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008849">
        <property type="entry name" value="Synaphin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705">
        <property type="entry name" value="COMPLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705:SF4">
        <property type="entry name" value="COMPLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05835">
        <property type="entry name" value="Synaphin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8194900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="16108" checksum="7A073CC401105B1A" modified="2024-11-27" version="1">MAAFVAKQMMGNKLNAVKGQMGGGGEAEAPEDREAAAELEQERLEALREAEERRKEKHKKMEEEREKMRQTIRDKYGIKKKEEEEEEEPLPEGSNLNRKKKTPAEIEAEDLDDFTRWRNNFEAQLGELRSTIESKCVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIA7</accession>
    <name>A0AAV6VIA7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_003547</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000068">
        <property type="protein sequence ID" value="KAG8196530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIA7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF236">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8196530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="663" mass="73892" checksum="FB7F4EB55D08CD88" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKA4</accession>
    <name>A0AAV6VKA4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000059">
        <property type="protein sequence ID" value="KAG8197099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKA4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8981" checksum="844129382AE5E93E" modified="2024-11-27" version="1">MYIKCTHENKEGLLIVHDWHQNSKSQGRLLFQFFRAIHMQPFQPRKPASYCWTSPLILFLYKRHYHCRNNQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKL5</accession>
    <name>A0AAV6VKL5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000065">
        <property type="protein sequence ID" value="KAG8196701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKL5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="134" mass="15224" checksum="30082D7E04F6DD5C" modified="2024-11-27" version="1">MYRLQTSFDSCYEWFDEKDLRSAPGYLIKYNNTKAPTPPNTPPSTYKNPSTVCQRFATLDNCINNLKKGISVMNSQLPLFPSSNCPFNDAYHSALYNRKRGFTRRNINHIIQDLDPGNPPASSQLESRVLFIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLR1</accession>
    <name>A0AAV6VLR1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trafficking protein particle complex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_006578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000066">
        <property type="protein sequence ID" value="KAG8196668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLR1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="548"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="587"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8196668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="78705" checksum="46B6014EFD0EFD22" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMT9</accession>
    <name>A0AAV6VMT9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_014892</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000055">
        <property type="protein sequence ID" value="KAG8197405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMT9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="76"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8197405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="163" mass="18560" checksum="8475204A07B1007C" modified="2024-11-27" version="1">MYSDETDYNPMPSSPTPTPIITNSSPTANSTIECSNEYCVPDEDYIGMIEAYIFPSTYEWVLISLHLTVFFVGIIGNALVCISVYRNHSMRTVTNYFIVNLAVADFLVILFCLPPSVLWDVTETWFFGSLMCKLVLYLQLSGYFQTATKDEYTDEKLSTFENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNE7</accession>
    <name>A0AAV6VNE7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_006804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000051">
        <property type="protein sequence ID" value="KAG8197758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNE7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06667">
        <property type="entry name" value="PDZ2_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06791">
        <property type="entry name" value="PDZ3_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000070">
        <property type="entry name" value="Multiple PDZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="33"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="193"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="347"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="490"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="680"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="945"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="1140"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="872"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1046"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="886"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8197758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1206" mass="132673" checksum="2116D990CBF82EB4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNG7</accession>
    <name>A0AAV6VNG7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_015300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000042">
        <property type="protein sequence ID" value="KAG8198202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNG7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043406304" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="101"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8198202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="223" mass="25366" checksum="920AA48E5DD73127" modified="2024-11-27" version="1">MQVFFFGALFLSVLIVFTATAHSDKGNSSIPGQILDHLPKRKISPLIDKFTIDYQILAKGEQSSLPAQIFEYLTAQLYYSQLELFNSDLKIDEIFRNIFQAVKELFLQNRLVLVNYLLYSSRNEGAKVLQFNKTSLEESGFDSSLDTKILIHGYTVELLNTSIYFDIIDKLLLSGNYNVILVDWTDYNQAPYYCAVGYAYLVGLDLANLIGFLLVRYSVTCTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP87</accession>
    <name>A0AAV6VP87_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_001572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP87"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043383787" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8197642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38967" checksum="5883ED841744F0BD" modified="2024-11-27" version="1">MFHKLVCLPLLAFINIMHCVSPPFNGDSTGTITTKHAVKHSQNLLEIYNNQHKVYSVPGSTQVYELPMRSKRGIVLIDEDFDVTPDLRVVEDKGPFDKKVDSIFKTTPRVYSISEESGSSETMSNDLILTKSFRTPRNVQMTKVLDHKTTTVAFGKSSVKKSTRFAEQDNFHERPRLLGQEWTTGADEDIDASGDGESSIVTNSSRTTIDENTSSKYTTPSTDDPDETTSSRYTTDEDTSSHVVDVTETSKKEVPDVQEDLCLNITCDSKDLLIVPNLTKAVPEGTNLTISCILPNATEQGLLKWYKFNSSDLLLLEENNVFTPLKNNPMNSGGKSVIFISGRGAGVLVNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPT2</accession>
    <name>A0AAV6VPT2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Eukaryotic translation initiation factor 2-alpha kinase 1</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Hemin-sensitive initiation factor 2-alpha kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_020268</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Synthesized in an inactive form that binds to the N-terminal domain of CDC37. Has to be associated with a multiprotein complex containing Hsp90, CDC37 and PPP5C for maturation and activation by autophosphorylation. The phosphatase PPP5C modulates this activation. Homodimer; homodimerizes in presence of heme, forming a disulfide-linked inactive homodimer. Interacts with DELE1; binds both to full-length DELE1 and processed form of DELE1 (S-DELE1) in response to stress, leading to activate its protein kinase activity and trigger the integrated stress response (ISR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000047">
        <property type="protein sequence ID" value="KAG8197889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPT2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054521">
        <property type="entry name" value="HRI2_3H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22949">
        <property type="entry name" value="HRI2_3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="140"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="217"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8197889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="619" mass="70409" checksum="32C25EE3B1D885B5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQW7</accession>
    <name>A0AAV6VQW7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_015121</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000034">
        <property type="protein sequence ID" value="KAG8198910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQW7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000287">
        <property type="entry name" value="PR domain zinc finger protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000382">
        <property type="entry name" value="zinc finger protein 35 isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8198910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="720" mass="83004" checksum="6C0AEA5B733DEED0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS46</accession>
    <name>A0AAV6VS46_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VS46"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="592" mass="68075" checksum="E96340183FB33C36" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT21</accession>
    <name>A0AAV6VT21_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA selenocysteine-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_015113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM TRSPAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000034">
        <property type="protein sequence ID" value="KAG8198901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT21"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000159">
        <property type="entry name" value="tRNA selenocysteine 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040434">
        <property type="entry name" value="TSAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041085">
        <property type="entry name" value="TSAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37457">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37457:SF3">
        <property type="entry name" value="TRNA SELENOCYSTEINE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17654">
        <property type="entry name" value="Trnau1ap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="5"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="95"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8198901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="315" mass="36176" checksum="77CF438DD504CA77" modified="2024-11-27" version="1">MNRKSTVWIGDLDSNIDEEFLVDAFRILGEPICSVKIIRKNTESLCYGFLDFPDEESAHRVLHRYNGKLIPNTSSKRFKLNHANYSKDSSLEKDYSLFVGDLGEDVDDLALFDAFVARYKTVKLAKVIYDNFGVSKGYGFVHFTSKTEYESALVEMQNAHIGSKSVRVSTAQQKSRTSVPSTPGSEEQQQWQQQYPGYDYQSYYAAWQTYQAQNPYYGYDQRYGAYGTAYQYPQQYPYADPQAATTTAETTPTAVPYAPSTYEIPETSIEEHDIPLDIDQMNQELMQRNEELYTALDESRWLPTENLDPPLIRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTR4</accession>
    <name>A0AAV6VTR4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_001913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000020">
        <property type="protein sequence ID" value="KAG8200055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTR4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043955763" evidence="3">
        <location>
            <begin position="18"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8200055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="139" mass="15729" checksum="95E15ECC8C1DAADB" modified="2024-11-27" version="1">MVFKVILISLCVAGSLANHYEHHEEHGHHPQPYKFGYDVHDHHGSQHRQEHGDGHGNVHGSYGFKDDRGIHRQVDYVADHHGFRADVKTNEPGTANQDPAHVHLHSSAHHELGHHGHHELGHHGLEHGHHGYGHDGYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVG4</accession>
    <name>A0AAV6VVG4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_000331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVG4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043110143" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8199466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="219" mass="23465" checksum="487A55DB9B8FC823" modified="2024-11-27" version="1">MLRFILPFICLVSSSIVFASGSSGTAAPKGPKVTDIVYFDISIGGEPAGRIEIGLFGKTVPKTVKNFVELATKHTTEPSTDGKLVGYKGSIFHRVIKDFMIQGGDFTNGDGTGGRSIYGDRFADENFKLSHYGAGWLSMANAGKDTNGSQFFITTKKTSWLDGRHVVFGKVIKGMSVVRKIESSKVSGSDKPVKEVVIADSGTLPVDKPFAVSKEEATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVH6</accession>
    <name>A0AAV6VVH6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_001935</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000020">
        <property type="protein sequence ID" value="KAG8200078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVH6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="11" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8200078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44225" checksum="FB4E3903FDD3E4A1" modified="2024-11-27" version="1">MRIGIVNVLRCKGIAIAKMLINAGCSTNVCARHPSIWICATSYSFKLTSDVVQLIVSMDNDNDLELTNELGENPLMMALRYGKYELDAISRMLHYLPERVWNTKSYLGNFILHAAASNRYADPAVIGMLVKKGADVNAVNRKIDTPLHVAVTFGTCTPDIVKALILNGALINDQNAFFQTPLIKGMVRELNPRALQMLFYAGARTDNQPGWCRLMLQFGLREYGREDENNFQSLKLVLKYALLNDPELEVKNLLLGMRAQEALISFVDECKTEIDENLGVEFCPNLTLLQCLQKPFQMRPILPYYILDKHDVDQMCAVLCENNIHVYLDDVAARIGRSVLTSSYLHSVYTVVPLKKGEKKIHLNYESILHVVKFLTNDVDILRLSLAFHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWG8</accession>
    <name>A0AAV6VWG8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_024950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000018">
        <property type="protein sequence ID" value="KAG8200162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWG8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043383799" evidence="2">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8200162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="250" mass="26767" checksum="CAD3BB5A49064978" modified="2024-11-27" version="1">MSKLSLIILLAVVCTLEANNFFYYPSTVGALNYQYNPYAPYVYSAYAVPVDCDKSGSDEGSSKESSESSESESSSKEVGESESGSSESSEGGEKAEGSSSEELKEGGESSSESSSSEESGEKKEEGKKEEGKKESKVKQVKYVFPPLSYPFPPTTAQQVVYSSPSYGYLPYRSAYSAIQQPTNYAVKSSGYNYQPYYGGSYTAPVARIVSSPVNKVVSYPGLTKTITFAPASGVGGPAGYWNGNVGYYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXK3</accession>
    <name>A0AAV6VXK3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IRF tryptophan pentad repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_000571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXK3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001346">
        <property type="entry name" value="Interferon_reg_fact_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00605">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51507">
        <property type="entry name" value="IRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRF tryptophan pentad repeat" evidence="2">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8200491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="245" mass="28382" checksum="0DA509A00518297C" modified="2024-11-27" version="1">MPPKPNYRLIPDFIVPNLEKETYGRHLVWDDKKKGSFKISRIHQSSEQWNDDCIAVYKAWSAMKNLWEPDDPKKCTKAKHRLITALRRNPVVEMLETEAAYYRFRIAAAKIEGEERTDKTLQQEKESYPYMEENVSPKNRGSNKNNNPPICSSRSSDPFQSNIKLLMALPERVSTVENKHDCVHTSCDFETEFNKEHFFTLDENSPELSNTPEKIYDCSDTCCCAVLLDSTLLSNERCIWHGVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXV1</accession>
    <name>A0AAV6VXV1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXV1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="10779" checksum="AF234BB3E1C78A28" modified="2024-11-27" version="1">MPSRAAKDMSDGLERLDLSYLGVCYPPDIDPMSVRRWEKAVSSGRMVHGKVVAECATLLGCFVGGKYVILDSGVVEVKVRKNFFNHLFGGGHVMVGDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZ77</accession>
    <name>A0AAV6VZ77_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_028814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000008">
        <property type="protein sequence ID" value="KAG8201152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZ77"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017156">
        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00276">
        <property type="entry name" value="C2B_Synaptotagmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="168"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="314"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8201152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="469" mass="52803" checksum="237B2649F5D4B11C" modified="2024-11-27" version="1">MNFKNLTIESETHIFKVSFRNFVDVKMLQLTENEKILILAICIGLLVLTTLITVCVVVPTCWLHVILKKISKKRKMKYGNKYGLEEGTFIKLAGAPQYTVECGPPIVRSNSKNNSLHNGGKNRKREDSTYSSMSSSSQGNASVSNYVSNHTSEASVDTPIIDIEQEVNYGQVTFSAWCRMSEENNLGELIIVLKEAQDLIPRSYGGTCDPYLTLQLFRDKSRKRWSKSSNVTLYEFRTASKKKTQHPIFKETFIMEVSKSDLKDGALKIAAFDDEKYANDSELGEITIPLREISFGRNGEENNTTRDFLEPKKEFGEILFGLSYLPTAERLTLNLTKAHNLKVTANSIENFAPFIRVLLMLNGKLLKKKKTTSRQATTSPVFNETLTFDVPPAQLDHIVFLVVASHRDPQEISSPDSPTSPPNNGSVVRKSRHIGKVVIGSSVKGLALNHWKAMKQSPRKQVTQWHILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W0A9</accession>
    <name>A0AAV6W0A9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_016810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000006">
        <property type="protein sequence ID" value="KAG8201333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W0A9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="57"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8201333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="187" mass="21004" checksum="AA821CA278A8D4FD" modified="2024-11-27" version="1">MRGGVMQKSSGEGRRRMLPCFGVATCVMLLLLAAGIRAVPEKIPIGAIFTPGTDELQTALKYSFHIHNTNDSQARFKVEPVIDIVDSEDPFKIARTLCLQMNRGIFTLIAPTGEASYDTLASYSNTFQVPFISPAFPELSSDRPAFYGLSLRPRYLRAILDVIIHYNWKVIYYLYDTDGGKFRLRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W142</accession>
    <name>A0AAV6W142_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W142"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11386" checksum="3277EAA5E68DC850" modified="2024-11-27" version="1">MTKAVPTKKFEVTQRFCHVVESFLQSRLDLMIFQRERKGCLAACFKDGLLLNGQERCRPPPPTTDSECCDLFLRHGHSYAYLMRCGHPFSGKEITARSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W519</accession>
    <name>A0AAV6W519_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MABP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_010392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W519"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF30">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN CRAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MABP" evidence="2">
        <location>
            <begin position="41"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8202021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="111" mass="12477" checksum="D1324E5AE1B2F057" modified="2024-11-27" version="1">MRSMDDKRVADYFVVARLQNNASPLDEISRDGNVPKDTHGLVPIVDVTVVIRSQGESIPKGFTCIELTPTGFPADLNHGSLRSPNVFFCYRRGRDKPPLVDLGYVDWRMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCU9</accession>
    <name>A0AAV6TCU9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006944">
        <property type="protein sequence ID" value="KAG8155720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCU9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043608156" evidence="1">
        <location>
            <begin position="28"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="180" mass="20279" checksum="D07E269C61C20A97" modified="2024-11-27" version="1">MVSADNGLLVLVFCFLGLPSPPRPCACWALRRPKVAISPFSLRVGIWLDPVQGLQPPGNKDGPRCPREILFVVDFFVFSHPLCWGSLLVGMGPEEGFVWGPSRYGFLFWVFSVGFDRNVVLSFFLGLPISEWWLTCSSRPWGHYRPGQLEQDIFGEQGSGKAITTKKLKKDFNKKAWLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEJ8</accession>
    <name>A0AAV6TEJ8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005792">
        <property type="protein sequence ID" value="KAG8161374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEJ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8161374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="10013" checksum="835D5BEFECD1C064" modified="2024-11-27" version="1" fragment="single">ISSPLAIVFFNKGYESNFDITPVSEELIFNNFNEFSIMIYGEFAFSVDTGNLKTMEALNESITLKDPFTKPGLTNRDIETINNLYECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFQ9</accession>
    <name>A0AAV6TFQ9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_011558</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010005096">
        <property type="protein sequence ID" value="KAG8170640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFQ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="173"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8170640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="492" mass="56373" checksum="FDC851CACF09B74D" modified="2024-11-27" version="1">MDTAQVDPFRYITIAAACMACFRSQHIPANLIAMMPSNGYINTTNFSRDSIRWLEWVAHQESITICHALNGAGEVKVGGISVDGFCQSTRTIYQFHGCFFHGCLQCFNPDVVNPVTSYTMKLLNDKTRENTEKLQRQGFTVVEMWEHDFKAEKKNNADLKSFLSTLEICDRLNPRDAFFGGRTNAVKLYHEGPSKYIDFTSLYPYCNKYSRYPVGHPEVLIPAVGETDIEGYFGIVKCRVLPPKGLLHPVCVYRCKDKLMFPLCRTCSETLQQTPCNHTPEQRSLTGTWISEELKVAVEKGYVILKLYEVYHFKESSVTLFKSYIDLFLKIKQEASGWPAECVTSDDKERYLASYLEVEGIQLDPSQIQFNPGRRAVAKLALNSFWGRWGMNRNKTHLQYVRSLEAFNKVLTDNTKTVEDIFFPNDDICGLQWRQEEGFLPQDITTNIFLAAFTTCHARLKLYSELFKLDRSVLYFDTDSIIYASNGHNDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGM1</accession>
    <name>A0AAV6TGM1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004839">
        <property type="protein sequence ID" value="KAG8170815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGM1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16269" checksum="984CB409548FC360" modified="2024-11-27" version="1" fragment="single">MFHFVLSIAVYGGGHAEVLDLTHNSEGGGVQFDDPGWMEHANSLKPLGLCILLNVCHSGARDYHTSFYDHLASLAMRNHLPLHNNGCLCDLAKQIGFSDSVVDYYRMEQLLGVFRRGLPSHSGALGVPRLRMPLPSMTAATLTDLHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGT9</accession>
    <name>A0AAV6TGT9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004719">
        <property type="protein sequence ID" value="KAG8170890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGT9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="66" mass="7362" checksum="63A5D4FFE58D0E8B" modified="2024-11-27" version="1">MVHGPARKLHYLTLGCSRANRGAHREPPPRAVLLRETSPSVPISGRDDSRGHELLQRKENLFPVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THA1</accession>
    <name>A0AAV6THA1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004414">
        <property type="protein sequence ID" value="KAG8171107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THA1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="144" mass="16200" checksum="D0238665BE13F412" modified="2024-11-27" version="1">MVTETALATVLPNLGPSGAKRLSLRSDTEIYEYSSLFHYVASKYHECRNPENCEACRNFHPMASAIPEPMHQESPHVLKQDPEFVNMSWTPFHDNMPTPPYQYMGMYQTQGGLSQGVLPYSPPTSPPNQPSANLRTHIQLNATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THC0</accession>
    <name>A0AAV6THC0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004469">
        <property type="protein sequence ID" value="KAG8171073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THC0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="228"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8171073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="378" mass="43096" checksum="863A33B9C0B77A90" modified="2024-11-27" version="1">MSIDELNRKLDAYLEHDVLTLRCRVWEENGSVSEPPVDCFAKTEIKIAQLNYRWILEDLMGPDGILKHKFKRSTGILNFSSGFPTIRIHVSTGETFDDDSIYLGSKEYNGSSTPLFSVCNIHLLDSYGSIVHSICGEAEFQNSNETWKFPFLAKHKLLSNTELYLPGGKLTLQCELSFSGDLVVNCVEFGKTDKEIFNSEKPNEDSVSDGQELWKENMRQFYSDGEFSDLLVRTPNREFPVHRAILCAQSEVFRGMLSHDMKEKNSGVIEINDFEDDTVSKLLLYLYTNSLSLDDIDYVLAKDLYFAADKYRITPLQKICSNHLIESIDSSNACDILLLAEQLRDLELKATARNLIASSPYEIMNSVTRNSRKEHLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TK62</accession>
    <name>A0AAV6TK62_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_011144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003448">
        <property type="protein sequence ID" value="KAG8171871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TK62"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8171871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10750" checksum="E3BFF08FD805CD05" modified="2024-11-27" version="1">MVMKKHSKEGRYEKEKPPPLPMDPVVGDIYNGKVTNIMQFGCFVQLESLRKRWEGLVHISQLRREADVDPVSGTWSRKDRGSKLSVVVHWSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLC8</accession>
    <name>A0AAV6TLC8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002460">
        <property type="protein sequence ID" value="KAG8172684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLC8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="82" mass="8392" checksum="6F39B24104DFB893" modified="2024-11-27" version="1">MGIVDSDSDIPLGSTDMGNVSHLVPSIHPFYALPTDAPNHSRPFTDAAGSPSAQGPTLGAAKALALTALALMRRPGVLEKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMQ4</accession>
    <name>A0AAV6TMQ4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002196">
        <property type="protein sequence ID" value="KAG8172971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMQ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="9415" checksum="4579E4F74270F6B8" modified="2024-11-27" version="1">MGLSKVFFRQYLADSWHLDKIGCLDTFHYLLGLMPQVELLSPQLMEGRLDLLGGQDPIALGKEAAKRLLANMKYAGSEEFWDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNK8</accession>
    <name>A0AAV6TNK8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposable element P transposase-like RNase H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_007592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001934">
        <property type="protein sequence ID" value="KAG8173263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNK8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="2">
        <location>
            <begin position="197"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8173263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="265" mass="30245" checksum="F20895766287AB13" modified="2024-11-27" version="1">MTILRLNYEWLWKVPTQSIFDDLQLSKQTTRTGFPFAGRFCFLDLMQHPKIIGGSKVKPPQKKKYSPQELESETGCCSNNFSTQAVSSDLQEQLTSANSTISDLEVQLLSANQAFADLKKQIDEELLHTSREIFTLAEENKKLKVQLQQQSTSITNNLLKVFPNRDQIKALQGTEKRHRLDSTEAIRRFEIRSRVLNEVLEFLKVNISSFCENERKCALLLDEMPITPSFEYDSSTCTYLGSSTFPGFACSALVIRIRGISSKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNM7</accession>
    <name>A0AAV6TNM7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_026593</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001705">
        <property type="protein sequence ID" value="KAG8173494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNM7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8173494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="282" mass="32565" checksum="75BF077310615F0D" modified="2024-11-27" version="1">MELEDLSSIKNRKKNNTIQTSESCKDKMESILELEEEENKLQQRKQENVYTNAGYREAVTHFVKTMQTVNRTYEGYSFEECKDVALKTINESCLRKILDLEECRDAWNEIVDDSCLMAIMNFTDCGDLGEMGSPYRQRSFSLEPKLKKRTVVSYQANELIKECSFNGESCSIKDLKLFQSLRYGNCFTFNKAESNSSRRLMTSKTGYRSGLHMTLDVRSRDYLPTSHTIGARVIVHPSSSDPDRENLGINISPGFETSVSLQSHISRLEYPYQDRCARLRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQ14</accession>
    <name>A0AAV6TQ14_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Senescence-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001333">
        <property type="protein sequence ID" value="KAG8174075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQ14"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15009" checksum="036A8C8B821BB9A2" modified="2024-11-27" version="1">MIGRADIKGSKSNVAMNAWLPRASYPCGNSSDTSCIKLVKSKGSIGPAFAVRIHTENQDQASFCPFALREVSVLAELALGHLRYYLTDVPPQPNNPPESVLGADRALQGGSALGARSVILTGRFPLNRVSKETMKAVVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRP3</accession>
    <name>A0AAV6TRP3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA endonuclease RBBP8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001190">
        <property type="protein sequence ID" value="KAG8174532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRP3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="12263" checksum="2CBEE8D270E6061C" modified="2024-11-27" version="1">MASTTAYPCPECKDYYAVHGEYVQESCRHRKRECRTPPGFWDLDFSDEPIPVEGRMSPPPRRNRYDVPEKKKVECRPLPLKRGWTRVIKDDPLWWQKPIECDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSV0</accession>
    <name>A0AAV6TSV0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_007384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001173">
        <property type="protein sequence ID" value="KAG8174636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSV0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF227">
        <property type="entry name" value="GLUCOSE DEHYDROGENASE [FAD, QUINONE]-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="88"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8174636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="184" mass="21051" checksum="3672122ACCB3F960" modified="2024-11-27" version="1">MLSGIGPKEHLRSLNWLPDKQVPWWPVACPTIHACGCYFRKLEDRQTRLMKLLRLHSSCRIRKWTGGIRPCHRRGEHSDSKTRLTSTGGLLSVSSSQYNSTLKTAFAKATSERDYGYRDTNRAKQTGYSKLQGTIRNGRRCSTAKAFLIPAQDRKNFHIFNNAHVTKVLINSRKVAYGVRFDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSY9</accession>
    <name>A0AAV6TSY9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001086">
        <property type="protein sequence ID" value="KAG8175042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSY9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="459" mass="52642" checksum="75DF5E535F86B824" modified="2024-11-27" version="1">MDAGALPSAGNLDIKDENTTRSSYKKCFRLLKMSILVCCVAGFSLQTAEFLNDFYKYPVVVSLEYEGIEEFPVPAFTLCSKYWYDFKYYCQKFPDKCETTEYPENFCEYHPQSCKRNATHGIVPTSFPPHYLSDRFLKIFAYNSSIFTVKGDYPTIITGPFFTVTDGVHECCFTSNNGFGINGLRKAKGSLLQDQISWFFHYFHRNSLQSEFFFTPEAAPYGTLYVHSPLHAFKKDDKSLIFKGGKSYVMSIRLSMKGLLPHPFESDCRDYELSWKRNNNTGPVSREMCEFECAEEDSSYFEKEYAVWSNKRLCTYLGEDSVRAEELEHWRMIAEKLKEDCECIVSCKRDCCFVFISLACEKDDIPVTYLKPKYNDVDLFIYIGGLMGCWLGMSLWTCTGILGRGISTLGRGISTLGRGISTLGSALSKYRRAKRAQRKQKKKPLTNKGSKKEEIKEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUC2</accession>
    <name>A0AAV6TUC2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_022641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001048">
        <property type="protein sequence ID" value="KAG8175218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23160:SF19">
        <property type="entry name" value="MYOSIN HEAVY CHAIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23160">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="496"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1334"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1614"/>
            <end position="1641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8175218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1690" mass="194914" checksum="5D5FD10DC9E4E88D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TV09</accession>
    <name>A0AAV6TV09_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_004165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000996">
        <property type="protein sequence ID" value="KAG8175473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TV09"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000124">
        <property type="entry name" value="Galectin-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF147">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="179"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8175473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="310" mass="35100" checksum="32B01920F86BDD37" modified="2024-11-27" version="1">MTSMITRPAIPYRGNIPRGIHEGKVIEIRGAVPHGADVFTVNLLTGLDSATSDRPLHLSVRFGPRVAVRNHLERNAWGVEERQGPFPFQHGAQFTITIVAEATHYKISVNHQHCWQFNHRMPLWRVSSILIDGMVQIERIEFINRPGSCVSPPVNPPILRFNSRGGSTLGPVYNPPIPYAYPIYGGLVQGMVMHISGIPTTNAERFHINLQTGPSTYNIALHLSARFQCQTLVRNTCVSGTWEREERDLPRFPFAPGLPFQLCIRVQKNRFAVELDGLHLLTFAHRLRPISNFDTLFIERDVQVTCIRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVW0</accession>
    <name>A0AAV6TVW0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000939">
        <property type="protein sequence ID" value="KAG8175898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVW0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9631" checksum="30B7258B0E991428" modified="2024-11-27" version="1">MKSGRVDTCYAIAMVFILQIVAIEIAHKKRSHTMNRYLNDIHKRPMNKGGICRNDIHWKRRVVLLEVLNPENENPLTMPDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWJ2</accession>
    <name>A0AAV6TWJ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_012391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000916">
        <property type="protein sequence ID" value="KAG8176138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWJ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="285" mass="32375" checksum="F94E210CB0AFAC1E" modified="2024-11-27" version="1">MNQIEVAMSHWCYDLTPAAAHSFSFIAFGECIAVCSIRIKMSHTRKQVNCPIIGSPRELSSIVLPTREDILRHYNWIRLQKENAGQYKPKMCEIYEEIAAKVEQIWNKASVPVLHRVRIISLIKREHEKLLNLLKSYHGRKKNFNFQHKVQAFKKEANALFDVAACKCNDFELCHCEKSRKVPIKEQPFITDQISARVMAIGSVDLRTAQQLQKRASRKMRDLNLEARIAELQKSELATSTESLETSGEYVVVEEDAVVVDVDKDISLAEGSDGAKSLPSTSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWR9</accession>
    <name>A0AAV6TWR9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000939">
        <property type="protein sequence ID" value="KAG8175929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWR9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="106" mass="11918" checksum="7FC27531BDCCD5B3" modified="2024-11-27" version="1">MSIYLTDADQELYKNFPVVISERKMKFDDEKVFCKEAEVGLTNACAQALKNRHARHRWVPTCEHGRLKSIGTSKWLKSRAKFTGASHDIAARRVGPMPGASSSSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXL3</accession>
    <name>A0AAV6TXL3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000911">
        <property type="protein sequence ID" value="KAG8176201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXL3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="10538" checksum="20CEFCEC4847BF2E" modified="2024-11-27" version="1">MSTLMCTLHKSPKLNSAIIQPKPNQAARKFGDPLIVAKDPFSHVLGACAATLVDREEPCGYGCRGAQHESPSPSHVPLATLTSRHFSTAGSACSRYLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1H9</accession>
    <name>A0AAV6U1H9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CFA20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000740">
        <property type="protein sequence ID" value="KAG8177876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1H9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="2">
        <location>
            <begin position="6"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8177876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="317" mass="35680" checksum="A67FB8370E2A7851" modified="2024-11-27" version="1">MSHNGQRYVELLSPTNKDILNAWKVLPGTKKVFDDKLKSFVFCLKGGKAPVPLLQWPKDKANVVLSHPIIVFQMFLAARDNILFDIRINCNNILKKRISLSSNQKTVSKTSLSVILPVTILNRETWSYLLVDIEEIVSSVWSRDSFRNVGSVCLSGNCSIKRIFTLRRDMVQNEEGVQFIKYDQIPKQMLLSKTSPPTYDFVICLNNSEAEENKSSTNSLANQSEVRQSTSSSLTSINGHYNFMKSASRNPSISKSNKNTGGLPLHTSNKSEYSFRDEDNRSKCSTVEDNSVSADHVLPLLSRLTFARALGEYTDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3F5</accession>
    <name>A0AAV6U3F5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_017466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000717">
        <property type="protein sequence ID" value="KAG8178119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3F5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043496187" evidence="3">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8178119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="154" mass="16950" checksum="CA8F7C64326E1925" modified="2024-11-27" version="1">MKSTTLSVFLLAAILSTTLAQQQRPNSTSRATAATNDAKVTAKSARSEFHHQHHGGGNFEHHFPHHFGGGHHLGGHHKEFDHYLMPLLVILGLGVLVMPLLSVLMTTMVGNVPVTTLVSGRKKREIFGEAAEDKVADLFKRFGKAYEAFNERNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3I2</accession>
    <name>A0AAV6U3I2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chorion peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_006288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000713">
        <property type="protein sequence ID" value="KAG8178149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3I2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000003">
        <property type="entry name" value="chorion peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF143">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043451038" description="Chorion peroxidase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8178149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="81553" checksum="AB749F565B7F1966" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4X4</accession>
    <name>A0AAV6U4X4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_014129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000659">
        <property type="protein sequence ID" value="KAG8178923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4X4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043596770" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="16"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8178923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="575" mass="64019" checksum="E75A6DE957C747E2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5Z2</accession>
    <name>A0AAV6U5Z2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000642">
        <property type="protein sequence ID" value="KAG8179248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5Z2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="10457" checksum="2CAB3E065BB21ECC" modified="2024-11-27" version="1">MLLSSLTLSSIHPKAPISNTTNYHSPNPPPNSPKKKKKSPNGKTLYSPPRKGKRTKNLGIKRERRGEISPSYPDDARMFPGCSGEKKTGNGEGTGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6G6</accession>
    <name>A0AAV6U6G6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_027205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KCMF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000623">
        <property type="protein sequence ID" value="KAG8179493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6G6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010646">
        <property type="term" value="P:regulation of cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02338">
        <property type="entry name" value="ZZ_PCMF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008598">
        <property type="entry name" value="Di19_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05605">
        <property type="entry name" value="zf-Di19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="345"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8179493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="468" mass="51269" checksum="B537D3E98B7DE33E" modified="2024-11-27" version="1">MSRHEGVSCDSCLKGNFRGKRYKCLVCYDYDLCATCYEAGASTTRHHTDHPMQCILTRSDFDLYYGGETASVEHPQSFTCPFCGRMGLTETVLIEHVAAEHSESSAEIVCPVCASQPGGEPNHMTDDFSAHLSLDHRNREIQDEPSSSRHTRRIPHAGRGTSSNRARRSQMQFTSAGGLASLSPNSRDSMDPIAELLSQLSSVRRSNLAQTNTTSQLQQLQMQLQMERQQAQMARQQLERMPRRQGASSVTSVVGGSLQTHFTVSLDAVSSSPSAAQAAGSSSRPQFLLSRCTDPVITEGEQQALEVEHAERSLFVQELLLNTLGEQFNTEELDSLVKVIDLNSSDPSGSYPDVNDNHSPRRDPVSAIPPDSPPQPHPEEVQQPRASNPEPLRPNLRVQNRGASSNSFGSSNNPVGRGSGAAQRVPLNSGGRPVNRTTPRERGSSPTRRKALRQVDDRNKTTEPPPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8C9</accession>
    <name>A0AAV6U8C9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_007465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000560">
        <property type="protein sequence ID" value="KAG8180510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8C9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052751">
        <property type="term" value="F:GDP-mannose hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055295">
        <property type="entry name" value="NUDT22/NUDT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31835">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31835:SF1">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="118"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8180510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="290" mass="32794" checksum="4BBCB37A34615542" modified="2024-11-27" version="1">MDLKDSLKILCSPGKGYSQSSISLEFSDEFCMKSHPLHASIETEWKKKLKESINLFNASKFRLHRIIFQQAYEDHSYPLKLYVGTTSYKDFIGTNCAPYAHKLVQDGLEKSNSQLYLSDPIGVGGLLVTSDDQLVFIKRSEKCAEMPGLIDRPGGHPEPSEVQTVTGQSLKDVDPSAIVEEIFQSVLKEIRDEVNIPVHELSQPILLGVGYNPNTWKRPSMEFYVRCNLSSDQVAALYKEQTQAESDESTEILIVPVAEVLKSCLENFKYFNKLTHPAKTALYFLKIFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8P2</accession>
    <name>A0AAV6U8P2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_016490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000575">
        <property type="protein sequence ID" value="KAG8180213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8P2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8180213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="496" mass="55752" checksum="E3AFFD6F3587572B" modified="2024-11-27" version="1">MELSNKSSREHSKCVMSCEAIGKSSVHALSQLSQAKSSCARVFWLVVFVVTVSGCAYQVYSFLYVYLQYQVLIDLKYQRVMALDFPAVTVCNLNGITLNHIDCVNKSLTWDQCHPIPRQTGSGQMGGSGGYGGGSGGLPLSRTLSYSLTSTSNTSELQKSYNELAKNLLNRYTKLDGMSRRCYGHRLDDFILKCSFNSVTCDYSDFEYFLSKQYGNCFTFNRKTENNLNAKPRIVKRAGPQSGLELVLDVGLNSYSKVTPSFGVRVVIHNPQEDPHPSQKGVNIPFGVESHLSLAKTSFHRLTSPYRDDCKNYPPTGGLNCVDECIQRVSMKLCGCVDPFLMAALPKKVLCNLLNETQTACMGRVLDVLSSNVEERLHTCDCRLPCFSTEYDVQLQNMVMNRALVMRSVMSDRHFGKSYEPEECRGEKALMPPTKLKVFFQTLDHKIYVQKPMFSYSELYSQLGGNLSLWLGLSFVAMYEFAEKVFLFVKVALHMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8T8</accession>
    <name>A0AAV6U8T8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000556">
        <property type="protein sequence ID" value="KAG8180675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8T8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="129" mass="14090" checksum="4FFC52D7AF14EB3E" modified="2024-11-27" version="1">MWTIPFISKGSTNKWVAYQQHQYTKPPFFLTIDLSPATREGPFELADPKGVCRAPKTPGPGSQTGRGYKKAPRRSREPESVGATANDDTLGSWLYRGNGARVEGLNADPTVGFRSLCTNFGRGWGAQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U926</accession>
    <name>A0AAV6U926_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_020472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000579">
        <property type="protein sequence ID" value="KAG8180176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U926"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19489">
        <property type="entry name" value="Rad51D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051988">
        <property type="entry name" value="HRR_RAD51_Paralog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047323">
        <property type="entry name" value="Rad51D_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048943">
        <property type="entry name" value="RAD51D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21794">
        <property type="entry name" value="RAD51D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="80"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8180176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="313" mass="34574" checksum="E201F636CACEB94D" modified="2024-11-27" version="1">MVMPRLFEGICPQFTQPVFNQCKQVGIKTVADFITQDPEILAKKMKTPFKDVLIIHRSLTVQFSGFTQSASSLFNDLLETISILDTGSKSLNRFLKGGVYTGEITEIHGPPGSGKTQFCLSVISNLILESNSTVLYLDTSGNFTGKRLLLMLQKSNDKQDFTKKLQNVKIMRIYDIYDLFDSIESLVSELNKQESRFSRHLKLLVLDSVTPLLAPCFGSKFLDAVSLINNLAQQLNGLCSDHKLSVLVCNNTVQAKGSLIKPALGMPWKYVPTVSLSIEKSNNPVHKIKTVKSCRSGLSGSVSFKISEAGITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U984</accession>
    <name>A0AAV6U984_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000559">
        <property type="protein sequence ID" value="KAG8180634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U984"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8797" checksum="B175C04A43DA5B00" modified="2024-11-27" version="1">MSTPRRKVGGGNDTTGHKKLQSDDEVLNAVKTKKKQGQCFSARHILLFSVVRPLKHSQFVRHAIDSLENTMAKKRPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UB22</accession>
    <name>A0AAV6UB22_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000564">
        <property type="protein sequence ID" value="KAG8180436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UB22"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="115" mass="12216" checksum="55F47C9D173EB63A" modified="2024-11-27" version="1">MSGEYPDSSKPEPPEESHATPLCVMTLLVPSSAHFGPLGLSDSPVLESFGDVHLHLGEHSNPPSLVGEYCGGSRQKSRGNCTPFHCIKGRGEGKSIKVGRELIARAFVFDCHSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCY7</accession>
    <name>A0AAV6UCY7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000473">
        <property type="protein sequence ID" value="KAG8182242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCY7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19596" checksum="56AAB65BDB6D571B" modified="2024-11-27" version="1">MFGKLGSVNRCFALQICSDSNVIPFLRELGLIKDHLKCPKCSADMKLKPERKISDNLVWICRNSENRKTCGCKRSLREDSWFRNSKMTLQEVFLLTYELVKRVKHRHIIEEYGFAESTICVWRRYNWSEYATTVLPIKRKRKPAASSTASASIAGSSTSPLPSTSIAGSSDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDK3</accession>
    <name>A0AAV6UDK3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_017330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000507">
        <property type="protein sequence ID" value="KAG8181580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDK3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF11">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="170"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8181580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="269" mass="29500" checksum="1F2F8D943A01892C" modified="2024-11-27" version="1">MFSKLDNILCLERKRENRKSSFLIRDILNEDDEDDEEVIVADEEDFHPGPSLLALPQGGALWDTAGAVYSQPLVQHHEDLLAARGLQRGGLCTSSSLSLCCLNCPPQSWHTGFGDMISPSSLPIHSNTPIALVPSAAATVSWSASAEAAAAAGNPIKECTGGGGKGGRKVRRNRTVFTELQLMGLERRFDCQKYLSTPDRAELARALNLTQLQVKTWYQNRRMKWKKQVMQGGCTVPPTKPKGRPKKNSIPSLNETRTANELAALKDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEW6</accession>
    <name>A0AAV6UEW6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_008610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000482">
        <property type="protein sequence ID" value="KAG8182075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
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    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        </location>
    </feature>
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            <end position="164"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8182075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="391" mass="43747" checksum="01392A3E4F3D68B2" modified="2024-11-27" version="1">MSVVQVVAHITPLNSVPSSSPNLLTTSQLGDPISVETRVITDPRNGLQYTMETAIIVKKYSEASDGSVEAECEGIPGLVCAPLSCPMLGKIRAGEENKCANLSLPYSICRENIPQLAAPESEKTQKLKVKFNLKSVVRKGPQGKESFETDNLGNEMDEPSASAKKTGRDLVKGLMRYIIEGECLICGLVDLGMNTAQHLSEHISKNSYRCTCHHLPFHTPRSLYVHMLNKCDTYLYTCEVCGTRYQRKHLLTVHELKNHTELAAPFEASEEVFRQNVPSCYSCSSCGDRLTLMDDINLHQDLHGRETTFQCLFCGRRFAELGALQSHVHVRVVAKKFACKVCTEEFSSTRALQVHQVSHTKDPWVCTMCGDKKFYFEKTYVKHMKLIHGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHJ9</accession>
    <name>A0AAV6UHJ9_9ARAC</name>
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        <recommendedName>
            <fullName evidence="2">BAH domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="3" type="ORF">JTE90_006467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000425">
        <property type="protein sequence ID" value="KAG8183273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BAH_dom"/>
    </dbReference>
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        <property type="entry name" value="BAH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
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    <dbReference type="InterPro" id="IPR048924">
        <property type="entry name" value="BAHCC1-like_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056841">
        <property type="entry name" value="TNRC18_BAHCC1-like_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12505">
        <property type="entry name" value="PHD FINGER TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12505:SF24">
        <property type="entry name" value="PROTEIN WINGED EYE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21744">
        <property type="entry name" value="BAHCC1-like_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3_TNRC18"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="2363"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
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        <location>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8183273.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIY2</accession>
    <name>A0AAV6UIY2_9ARAC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">JTE90_004906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Arachnida</taxon>
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            <taxon>Araneomorphae</taxon>
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            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000424">
        <property type="protein sequence ID" value="KAG8183286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIY2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="8186" checksum="1637E97C068CF87F" modified="2024-11-27" version="1">MSFLGKGKKQDLLVVCEELGEEVDHLSKVPEIKKVIVGSESYDEIEVKIEMLDRIIEERLRSEENEKQEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKU7</accession>
    <name>A0AAV6UKU7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_018719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
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            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000377">
        <property type="protein sequence ID" value="KAG8184313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKU7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="1">
        <location>
            <begin position="51"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="2">
        <location>
            <begin position="216"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8184313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="551" mass="62973" checksum="08E1AEB39D4147AA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULC7</accession>
    <name>A0AAV6ULC7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000375">
        <property type="protein sequence ID" value="KAG8184355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULC7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="148" mass="17194" checksum="9A1EF98ED2C817F1" modified="2024-11-27" version="1">MDPQDAGNYRPIALTSCLCKLMEQMVNARLVYCLEEKGALSPFQSGFRHHRSTVDNILLLETSIREAFVRNRHLVSIFFDMEKAYDRTWRYGILKDLYHLGFRGNLPVFIQNFLKTRVKFVSDPLCLETFTNEKVSLKAASSAWCCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNL5</accession>
    <name>A0AAV6UNL5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000315">
        <property type="protein sequence ID" value="KAG8186045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNL5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="7633" checksum="C7386F3D3DF56F00" modified="2024-11-27" version="1">MFKVTGILGALDDRESMSVSSVPTTEMPSQVPLRATPVSMPSPIECSTPSIELPVHNQEEAPPQSLASSPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UP55</accession>
    <name>A0AAV6UP55_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_019768</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000334">
        <property type="protein sequence ID" value="KAG8185514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UP55"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16744">
        <property type="entry name" value="RING-HC_RNF185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000062">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8185514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="208" mass="22746" checksum="CDA4FFE38A28F76E" modified="2024-11-27" version="1">MEGCDITSASFKKLKTKRRTTRSTLNYSKNSFNSMPETEGATGGAEEASTAEGTFECNICLDTAKDAVISFCGHLFCWPCLHRWLETRPTRQVCPVCKAAISKDKVIPIYGRGGAQQDPRDKLPPRPPGQRTEPDNNAGQTFPGFGDGGFHMSFGIGAFPFGIFASSFNFGDTRPAPAPGAPEYDDDQFLSKIFLYIAIAFIIWLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UR97</accession>
    <name>A0AAV6UR97_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_015656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000293">
        <property type="protein sequence ID" value="KAG8186719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UR97"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8186719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="204" mass="24022" checksum="2D4A95C5503B4251" modified="2024-11-27" version="1">MGAYKYMQELWRKKQSDVMKFLLRSRCWYYRQMNTVHRAPRPTRPDKARRLGYRAKQGYVVYRIRIRRGCRKKQVPKGRTNGKPKNVGVNQLKPVRNLQAIAEERVGRVCKALRVLNSYWVAQDATFKFFEVILVDPAHNAIRNDPKANWLCDAVHKHRELRGLTSASKKSRGLGKGNKYAQTMGGSRRACWKRRNTLQLHRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URE7</accession>
    <name>A0AAV6URE7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000286">
        <property type="protein sequence ID" value="KAG8186891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URE7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="96" mass="11126" checksum="40333D7DF879C24A" modified="2024-11-27" version="1">MSALSTDLPPKLRIVIGFHSRSGFFTSFSWIHPPSFFPPFGGEGFERSIKMSLVMFCSRERLWVLKELVLASGRVYEDGCKRVNDIKEIFIRIHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6US64</accession>
    <name>A0AAV6US64_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_012374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000301">
        <property type="protein sequence ID" value="KAG8186455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6US64"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="5"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8186455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="132" mass="15899" checksum="32CAD7D6D8ED119C" modified="2024-11-27" version="1">MTKEDYKKRLVVFFSEKLDADKNGYISWDDYRLMALRTTFQQNNGEYNEDIHRKYLTHSRNMWESLCNDIGGSKDGKVNFQDLVNFLYDLTSKTRHFEELPDFLQNLAIEVFHMIDKKCDMLWDKDEFRFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USD6</accession>
    <name>A0AAV6USD6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_011682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000274">
        <property type="protein sequence ID" value="KAG8187312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USD6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052268">
        <property type="entry name" value="SAM_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20843:SF0">
        <property type="entry name" value="PROTEIN AVEUGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20843">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043428667" description="SAM domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="65"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8187312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="149" mass="17317" checksum="26A507E1092D0270" modified="2024-11-27" version="1">MISIFCFVWLFVMEESTFRKVRKEKPDKDKAANMTNKNSVSSTNSGKDNDNSANTNARPKLVFFWTNAEVLKWLRRHCEEYHTLYASLFLENDITGRSLLKMNDSTLERMGIKEKVHREVICTEILKLKLKSDILELKDLQKKKGGDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USH0</accession>
    <name>A0AAV6USH0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_020032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000277">
        <property type="protein sequence ID" value="KAG8187154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USH0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF76">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="389"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8187154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="611" mass="67967" checksum="A565F02B230D1BAB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USR5</accession>
    <name>A0AAV6USR5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000272">
        <property type="protein sequence ID" value="KAG8187432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USR5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="839" mass="95587" checksum="B051E85FF6852429" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTH1</accession>
    <name>A0AAV6UTH1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">small monomeric GTPase</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_008441</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000268">
        <property type="protein sequence ID" value="KAG8187555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTH1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000371">
        <property type="entry name" value="RAB40C, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-0636">Prenylation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SOCS box" evidence="17">
        <location>
            <begin position="180"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8187555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="272" mass="30717" checksum="D77B370EA9A4DC75" modified="2024-11-27" version="1">MSRTAPTIRSSHPKSYDYLLKFLLVGDSDVGKQEILGGLEDGSQESPFCGSSGVAYKTTTILLDGKRIKLQLWESSGQGRFSTIIRSYSRGAQGIILVYDITNKWSFDGIDRWLQEVEEHAPGIPKILIGNRLHLAFKRQVSEGTAETYARKHSMVFFEVSPLCNYNITESFVELSRMALLRNGMERLWRSNRVLSLQELCCRAIVARTTVYSIEQLPLPIPLKSCLKSYSMTTYNSRPHLLLKASLKKQPRPPHHPCDSLTSQCRKSCSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTM6</accession>
    <name>A0AAV6UTM6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Amiloride-sensitive sodium channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_000405</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000284">
        <property type="protein sequence ID" value="KAG8186935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTM6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8186935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="44701" checksum="04ABE92E59FE0BC2" modified="2024-11-27" version="1">MQVDSPDSVSLPAIGFCNNNRLRRTAMCTLDPDKCKWNQSNFCHLYPKYCVKDKDPMMAVPDDFNRTFTNRSFEYLNVVGQRREDLVEHCLIWTDTISICNNLVSEPVVNWAGYPNTCFTMESLWGQPDAQPRSIPVTSKVIVYLSMHPEEYLEHSQKAQAHVLVHDPRVHGNPTRDGIILLSGKQYNIYVSQTVTERQPAPYRTNCTDYLKMWRENGGRGPLTGRSCAEKCKMERMLQSVGCVPQSISYPNNNTICNRSMDKDPSLEIMKGCSRECAEACHETTYHLRAEVHDEHSEKCPTEDINCKQEYMLLHFLFNRFEVTTFVHERKFESVSLFSYIGGYMGMWLGVSLVALFDLAETLVNLLVIYPFSQSSRRKARVAEVADWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU20</accession>
    <name>A0AAV6UU20_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000251">
        <property type="protein sequence ID" value="KAG8187995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU20"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10487" checksum="9DA4DE05AE9FB889" modified="2024-11-27" version="1">MIHEKNTVEYISDFCNRKLALSHRGLCIIRVVLLLAPFSSSLESCNVCDRLNNAIHPRYEIPQDFYNSLGLEADKAGNIVFFVLVYFSKCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUU4</accession>
    <name>A0AAV6UUU4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000272">
        <property type="protein sequence ID" value="KAG8187418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUU4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="7931" checksum="393F9A4497684CD5" modified="2024-11-27" version="1">MQRRKNVPNRPFSTKYEFQTILNAQPSNPSAKGLAASRSLDRKGTGVRPDRCGYLHADDSSRAPVTGADRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVY6</accession>
    <name>A0AAV6UVY6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000258">
        <property type="protein sequence ID" value="KAG8187823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVY6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="9202" checksum="566F7B5D880C1950" modified="2024-11-27" version="1">MKTPNTCLLKETELLLKGNEIWPTRFKLWHKKIAGNLEVNGMECHLRRWVDGEECSFGVSLTNRNVPFRRSGMLVREVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWL7</accession>
    <name>A0AAV6UWL7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_008074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWL7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000007">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8188509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="253" mass="27858" checksum="BBFE3C4BC38DAD28" modified="2024-11-27" version="1">MSSIGTGYDLSASQFSPDGRVFQVEYAQKAVENSGTAVGLRGKDGVVFAVEKLVTSKLYEAGANKRLFTVDRHVGVAGAGLIADVRQVVETARNEAATYKADYSDAVPLKYLKDRVAMYIHAYTLYSSLRPYGASVIMGAYEFDGPQMYCIDPSGTSYGYYGCAIGKAKQAAKTEMEKLKLKDMTCEQLVKEAAKIIYIVHDEVKDKNFELELSWVGKITNGKHEFVPKNVFQEAEKYAKAAVEDDDSDEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXE6</accession>
    <name>A0AAV6UXE6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000251">
        <property type="protein sequence ID" value="KAG8188026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXE6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043753490" evidence="1">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="10450" checksum="FBB7B48EA9F49EE0" modified="2024-11-27" version="1">MKIFISLALLALIVVCMGEEKRCYSQEDCDNGYCCTGGITPWLKGSCKKLSEEGESCDPNPPTTGKYFLNCPCKENLKCDDSIMIVGKIRCIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXR1</accession>
    <name>A0AAV6UXR1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 91</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_007994</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR91 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXR1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141039">
        <property type="term" value="F:phosphatidylinositol 3-kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056327">
        <property type="entry name" value="ARMC9_CTLH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039724">
        <property type="entry name" value="WDR91"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23138">
        <property type="entry name" value="CTLH_Armc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="ARMC9 CTLH-like" evidence="9">
        <location>
            <begin position="54"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="258"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8188424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="683" mass="75761" checksum="13A02C0A3B6C1A8A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UY24</accession>
    <name>A0AAV6UY24_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-taxilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_025480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000222">
        <property type="protein sequence ID" value="KAG8189044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UY24"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="267"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="381"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="533"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8189044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="72341" checksum="57CB14BDF67E2658" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UY25</accession>
    <name>A0AAV6UY25_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000245">
        <property type="protein sequence ID" value="KAG8188251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UY25"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="9110" checksum="98F399D4BD186684" modified="2024-11-27" version="1">MDGRTEKGVFFRFWRENELGIPLRPLATKWEGPSMFEDYVWEWSSMECLFFLGDCPRNGKSSKWSFRHLRNVRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UY70</accession>
    <name>A0AAV6UY70_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000234">
        <property type="protein sequence ID" value="KAG8188663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UY70"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="10535" checksum="5341FDAC6820FCD3" modified="2024-11-27" version="1">MSPEHRFVLSSGRALHSDEGSSWSGLVCKLIVMGDTGTPCSVCMPGSLRTSIRYSDSIASSNPHIRASTMISTCNLIANSQSSSLFDMPSISTCVFSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZX1</accession>
    <name>A0AAV6UZX1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000230">
        <property type="protein sequence ID" value="KAG8188806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZX1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="734" mass="84039" checksum="11D217820BE94EA9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0L0</accession>
    <name>A0AAV6V0L0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000213">
        <property type="protein sequence ID" value="KAG8189523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0L0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="269" mass="30610" checksum="279936EC022C9048" modified="2024-11-27" version="1">MAIDVYNDSRLMTLSANSWPLRSLAKIHSDSQIATYREHGLDASFTPCASVFHYRNPNTYREMLDVVADTVMTPVLEELKAADCFSLQVDGSVDKYCIENIFITARYVTKSSGIKNVFLGESFSDKHGAEAHRSDLVYTDLEAMVSEVKHWRLCLKSVTTYYRTSAVRTGELKAISLETENKFLRFPTYFEVRFVEHLVHLASCCILGNLLAMQKHWNAVIESKHSNRIERATARGLAKVWISGGDKELLTALMIDVMRVIRNLQKDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2A8</accession>
    <name>A0AAV6V2A8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_009089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000199">
        <property type="protein sequence ID" value="KAG8189950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000008">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="9">
        <location>
            <begin position="559"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="346"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="390"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1112"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1112"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1132"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8189950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1472" mass="167311" checksum="315CF19C36E2D587" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2K5</accession>
    <name>A0AAV6V2K5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_017862</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000179">
        <property type="protein sequence ID" value="KAG8190597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2K5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="3">
        <location>
            <begin position="101"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8190597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="283" mass="33070" checksum="C7D38458EB15D526" modified="2024-11-27" version="1">MKCGQNKDPDGFTLVTNKQKRRKNKSKKCNITTPSLPQSEVEVFKRSKIETIQKDLYYSTFFSTFIENLNQALNNILQPLKHHPTEIMNVTDNFNNLDISSSNEVDIVCYGLGHFITCMIARYQLAFLLSLKEVLHADTVTVFDPVFLVEEKCFLKELGFDVLEVNEEAKRPIFRKTIFFMPHCDLPLYDNLLSANWNENGLPNLIIIGNSFQNYFLKTPERELKRKAKYVFYSWEIVTENTICNNFQFTDVFNDLSVHYFQSKDLATFQKFDICDIDDENIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2U1</accession>
    <name>A0AAV6V2U1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000169">
        <property type="protein sequence ID" value="KAG8190995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2U1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="161" mass="18233" checksum="7469BB69E9ACE636" modified="2024-11-27" version="1">MFSHIRRSHSGCSLPSWLITPGPVLMKNHVHPNKYHPLVQEVELLEANPEYARVRFPDGRETTVNIRHLAPRGLQPPQVPANNRGSLDRPGPEHPLTRCDHLQSENPDKLESANVSPPEVFDMLPETENENQASELSPEISPKLSTSSRIRRRPAYLSRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3Y7</accession>
    <name>A0AAV6V3Y7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000166">
        <property type="protein sequence ID" value="KAG8191122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3Y7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="109" mass="12066" checksum="F13FC88C876FC3AF" modified="2024-11-27" version="1">MLCLTNENKRCFYSVFYIGCSGRFGPSFLLGLRIGMVNQGKRLAVCKRVKTNIDNTGVRTIRMARVKKKPRDSFTSGIVGDINIAGTDGSLTTCFVLGVVWLVFVLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4N4</accession>
    <name>A0AAV6V4N4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aminopeptidase NAALADL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">N-acetylated-alpha-linked acidic dipeptidase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_012355</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position. Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000155">
        <property type="protein sequence ID" value="KAG8191639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4N4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.40:FF:000001">
        <property type="entry name" value="N-acetylated-alpha-linked acidic dipeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF77">
        <property type="entry name" value="GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="18">
        <location>
            <begin position="383"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="17">
        <location>
            <begin position="696"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8191639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="818" mass="92212" checksum="907661050BF37788" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5Q1</accession>
    <name>A0AAV6V5Q1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">IRS-type PTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_021967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000163">
        <property type="protein sequence ID" value="KAG8191233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5Q1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005104">
        <property type="term" value="F:fibroblast growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005068">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008543">
        <property type="term" value="P:fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01202">
        <property type="entry name" value="PTB_FRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038742">
        <property type="entry name" value="FRS2_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF55">
        <property type="entry name" value="FI23523P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="7">
        <location>
            <begin position="16"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8191233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="464" mass="52246" checksum="CFB20F301CFC86AE" modified="2024-11-27" version="1">MSIINIMGCISSRILVDDTTRPVFHVWNIDEDGHYIKSCQIQVTDTDLVLHQRGEPPIVWPLQSLRRYGFDTELFSFECGQHCPTGPGIYAFKCKEAEALFNALQECLLVPRSDSEVVNGDDTEPHSSLLDDPFLKPQPGPSSTLEHESRIMSLVRRAMPSAPVPTPSLPPKRRKFWKLAEYLSEGSIVGLPPLGSFNSGKKFLPRCCMIGTCINASKQHYMNNKVLRKTTCGSCRTCSLNMCVVQTNARTMTYSDRAKQADYGNVLDHGGHPRNCVHCCCDFKPTQKVSCSADDCPLHFNNCVDQITNYARLEKNNRMLGEKSTLRKEKLYQMQQPHVYTHIPTPVPKWPKTKSMSWRSLPQCDTHKATPKRSASHFYAEEKGKENVADSEDPKTGYLKLDSTLLRKHDSEDGSLSVVSSLSSKEGSDPEMYAKIDFEKTDELAEEARMEQEALLHVATQTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6B9</accession>
    <name>A0AAV6V6B9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_003279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000162">
        <property type="protein sequence ID" value="KAG8191268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6B9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="130"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8191268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="461" mass="52027" checksum="6A13FF2BE154AE9E" modified="2024-11-27" version="1">MKTIGNQFHTSEKYNHPEPLFSKPLHAFNPSRTIVIQNFLSEAESHVQSFVAMFGIVEICDLIKEDAPSCLAVVQYKYKRSAADALLAMPYCQVRGSNLVVNLLWNGPYENISSITQGVRRSFKECAEKRVVCVGHLPRVVTEGEVRRRCERYGRVDSVQVQPQEQGAFAYVVFGSAFSAAVANYCLRNSSTSNAALMLGYSENGSPVLLGPVRVRPLDQYTVPLTAFDVRCICTRFLDYSRTKGLFVNMQRKLPSHHFFRPGVPDYCVRIPTTQVKGVSLFLEVLLFGGDFLKNADDISEMAYQLCQHKYLFRFTVDFGLHKPIMTYDDGLTRTNNNQHFLRWNSFLVLDLQICFPWDCSAASEPRLEPRIQGMNHIHSDLDPKAEEGSASWFGVALRHSTISLAPMGSVSEETQHRNKVKFLVAEGLPFVRLAGSCDDINTYQLPIHVYSENKANLKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7M4</accession>
    <name>A0AAV6V7M4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_017987</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000139">
        <property type="protein sequence ID" value="KAG8192457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7M4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070935">
        <property type="term" value="P:3'-UTR-mediated mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12412">
        <property type="entry name" value="RRM_DAZL_BOULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000167">
        <property type="entry name" value="protein boule-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034988">
        <property type="entry name" value="DAZ_BOULE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176">
        <property type="entry name" value="BOULE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176:SF57">
        <property type="entry name" value="PROTEIN BOULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8192457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="340" mass="36886" checksum="A79131489B4BB155" modified="2024-11-27" version="1">MATGGRDEFRSGNNPDGTIIPNRIFVGGISENTDEDDLWELFSKYGEVKSTNIVLDKAGISRGYGFVTFETEEDARKVLADNEQHRLILHGRNLNIAKAVKKQPYGRASETSSAHSAPIVWPTQAYSGSPAGFSRDSVYYPQTTWPFMWPQFYLQQQCQYPPTAQSGYPQYIYSLAPPSDYPYAPAAPGASSDYSEASSADSVESVKSRPKQQPVSTSATDYERGRQSRSKISAASQSSGSTSSITRSSTGSAEAPASYMHSAPVHHMHHPVFATKTINGVAVMAYPRSFVMGSPVIHVKDGDSDNVFSELGYLQSPITPPATPLASIPCDFGSNAESIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9B3</accession>
    <name>A0AAV6V9B3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VWA N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_009722</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9B3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013608">
        <property type="entry name" value="VWA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF67">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08399">
        <property type="entry name" value="VWA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043921980" description="VWA N-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="VWA N-terminal" evidence="9">
        <location>
            <begin position="127"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8192698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="251" mass="29118" checksum="F8DB5B03A72EA5AF" modified="2024-11-27" version="1">MALKIFTISILALVLTNFNLSTAYDGFPSKEEISKWVELLQNSLLLDLDKYTGIKKLEKTYDDLRRAKLHKIDGPSLVHKMSSDITKYLEKKMGALEKLAEAAEKTIETYKFDPNINFTVQKFLNMKNFTDDDSRLVYSEKFNKPVNFSYSGVHIPVEIYEESIEILNGLNWTSSLDEVFRENAEEDPLIMQQYFGSYSGFMRTYPASKWIVLPQKPGFPDLYDVRLQPWYVHASSSPKDMLILNGMHYMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAW7</accession>
    <name>A0AAV6VAW7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_014595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000134">
        <property type="protein sequence ID" value="KAG8192811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAW7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8192811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9670" checksum="55387282508561E8" modified="2024-11-27" version="1">MFNPVLQIYFLNVATVLRLTTVVATPLLYFGSCRDLRHENYSKLSSTRHFHPSDCCNDTSTRDYHEPDEGKELVNLTDRHKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VB29</accession>
    <name>A0AAV6VB29_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000134">
        <property type="protein sequence ID" value="KAG8192886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VB29"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="98" mass="11003" checksum="5485EB1ED733AAB8" modified="2024-11-27" version="1">MSPPASQHPTILSLFSRPRSLRDPDRLLPRCNWRWDHGCLSPSDVTHTRPVYPNGRSAPAALRSRAAATTRGVRIDINRGHPHQHAETEAEPAQTHEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VB96</accession>
    <name>A0AAV6VB96_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_011424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000113">
        <property type="protein sequence ID" value="KAG8193864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VB96"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF42">
        <property type="entry name" value="FI18455P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043473539" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="286"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8193864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="359" mass="40723" checksum="7EBD8871B72AB346" modified="2024-11-27" version="1">MKRQTAGPKLWVSLLACLLSALHILPLSLHIGADAATALKFRRINSTLFHTRLQPQASIGVARRLPSPWAAKLVALRSSRTRADEEVTTTEALTTTQTSQGDETETPTLETNVTVANEDSFRKRSHQDPQQDDSPQRSVVWPARSRGAAASRRLRLPSPTTPAPIVLLKLLQPKPTRPAIYSLDGFVPKPSIQRVVSTEPPPHFQAKNLQLLGSAPRRRKAHRYSKVEEADDAEEEFYLDQETDGRRRKRKRKNKKKNLVSRYTAFARKGVPGEDFPVYTYIPQTEFDCGLQPGLYADPFTDCQVWHMCPGGNLSPRHSFLCPNGTIFNQKKRICDWWYNVDCHKHSRRIRSPDFLIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBC2</accession>
    <name>A0AAV6VBC2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">High-affinity choline transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_013670</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000112">
        <property type="protein sequence ID" value="KAG8193975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBC2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000008">
        <property type="entry name" value="High affinity choline transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF4">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="553"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8193975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="63130" checksum="7AA555A79918F057" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VC48</accession>
    <name>A0AAV6VC48_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000104">
        <property type="protein sequence ID" value="KAG8194340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VC48"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="106" mass="11596" checksum="255B996953D645F7" modified="2024-11-27" version="1">MHGKARGRLTCCLVEKQWEIGLPSEVGDCARNRPEEKFGEWFGGEKMTRLENGTMPTHLSPGNINPDALLECTKGVGEIDGAVESNGNEVTQARSVIAQKRASKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF15</accession>
    <name>A0AAV6VF15_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Ankyrin repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_028425</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000090">
        <property type="protein sequence ID" value="KAG8195274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VF15"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140036">
        <property type="term" value="F:ubiquitin-modified protein reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002091">
        <property type="term" value="P:negative regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000057">
        <property type="entry name" value="Ankyrin repeat domain-containing protein 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF31">
        <property type="entry name" value="LD31969P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="13" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="15" id="KW-1053">Target membrane</keyword>
    <keyword evidence="9" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Ankyrin repeat" evidence="19">
        <location>
            <begin position="155"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="468"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8195274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="533" mass="60882" checksum="625131EE1A6EAE86" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VG42</accession>
    <name>A0AAV6VG42_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000095">
        <property type="protein sequence ID" value="KAG8194979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VG42"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="116" mass="12431" checksum="49F1DE7FFBDD75A4" modified="2024-11-27" version="1">MCDLLVGKPDLPVGYPRLKSSTIQRKSSWDTRYEGAKTPDTTTPPAAEPSTNGMCVRPSDSSSETSPDVEHSSNTQSHTPTKNSPTSSASSSNNSVATIMDVVSDFCFVIYTVKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGA8</accession>
    <name>A0AAV6VGA8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_026391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000099">
        <property type="protein sequence ID" value="KAG8194746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGA8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF77">
        <property type="entry name" value="LD25952P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8194746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="373" mass="41445" checksum="E2DC089B49A0EC88" modified="2024-11-27" version="1">MAVANTEEKFLSAVEIIRSLPKSGSIQPSNDTKLKFYSYFKQATEGPCDAPKPSFWEVVNKAKWDAWSRLGNMSREEAMKKYVEEFVRTIQQYSLDDLDDPSLINEYSSLMGPYIEYAPKHIQDNYMLMNGKKTLNNNSEDYSEAGIPSNGNSSKNYSNDYHKPAADYPLNGHSVNGNDSDSDEFSDTLERVNDEDSPEDSTSNNKPLNNNDPLISAKGPNIVNVRGGNYQRFPTGRTGDSASAGPSGNGGNHMPQQPRGSSNQPSASSSTLMGGGGGRRGGDPNSELSSEVGEQLAMAVIRLQHIMEQVVVRLDSLETLLTQRTRTTMQVSNKKSSRWSIFGISPKLAVLIFAWPFIAQYLMYLIRKRQRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGK0</accession>
    <name>A0AAV6VGK0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000078">
        <property type="protein sequence ID" value="KAG8195775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGK0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8449" checksum="02C497F831F69233" modified="2024-11-27" version="1">MFRSSKNGRNQLGHKHTRSISGTTNFQFHLGCYPQVSASQEWDHRSAQGVVKRYKNNQQFVWPRGKRSSKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGK3</accession>
    <name>A0AAV6VGK3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000099">
        <property type="protein sequence ID" value="KAG8194718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGK3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="297" mass="34022" checksum="C9127EF0BB53A6CE" modified="2024-11-27" version="1">MGEGPEYYVLVQKLLPKLTAVEFLKLALANLDVITIETEEALLLLDKVMYKTATISKDFKMHLLTPEIQEKFQQRMKQMKLDEDNFMKMLEPYENSKGPYVKPPVVPEPKPAPDISQRQYKPDIPEKVPVAPSTEKKQAAYGSSARTVEKREAPKRRARSSSSSSSSSSPEETEPSYQDKIAKLQNEIARLNATKSTEQRSQPPATKYSFSLKKPEMPPRSRQMYRPSPPEEESYFEKGGSSSRPREPRSERGDRDRDHREPEPFSPRRSSKESYSPPRGYRGGKGYRPPFSYKRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VH51</accession>
    <name>A0AAV6VH51_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VH51"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="9915" checksum="EC58E15B2A618F86" modified="2024-11-27" version="1">MRYSNVAINSTLSRGIQSKRITKYILISLELPLSLILSKCPADPVDLTALARSADAAQLQPSALPAANATLAAAARGTKSASAATASAAVHPSAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VH62</accession>
    <name>A0AAV6VH62_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000087">
        <property type="protein sequence ID" value="KAG8195471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VH62"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="116" mass="13373" checksum="2A401F9C8FD5B573" modified="2024-11-27" version="1">MSALRTERSKRAAAEKHICLQVCDGKLMLRRSHKYCSQVQGQLNISGYNKCDFIVSTGTGELFIEEIAKDTIFWDNIMIPKLREFYLKSILPEIADSRIRRGLMCREPTEVKGIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHN9</accession>
    <name>A0AAV6VHN9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000082">
        <property type="protein sequence ID" value="KAG8195651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHN9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="8173" checksum="B063CCB1CFA215D5" modified="2024-11-27" version="1">MWYVLPCDNVWYSTVIYHFPRCKCVPTHAFIGSMRFIIVGGGHPLLASRKAFFPKQQEHILGGKRHISNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIX5</accession>
    <name>A0AAV6VIX5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000077">
        <property type="protein sequence ID" value="KAG8195842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIX5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000061">
        <property type="entry name" value="Ets DNA-binding protein pokkuri"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="2">
        <location>
            <begin position="44"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8195842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="131" mass="14819" checksum="D957E7CAFFE06ADD" modified="2024-11-27" version="1">MLCSQAADPLPPMAWPDRGISSLTGRMWDSASLRRIIEDFSSSRHLPVPSTRNAEPTLPSDPTQWSRDDVRQWVSWISSTQSLPPVHLDRFSMNGKALCLMSIDMFVARVPLGGKLLYKDFQLRLSRALYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJ77</accession>
    <name>A0AAV6VJ77_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_007854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJ77"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="258"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8196118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="39261" checksum="EB3C2BEF548E3F3D" modified="2024-11-27" version="1">MSSIECDLRNESLERPESGENVYDGSEFEKGYSKFVSFEELKGSNGYLDNDTLTLRCRMWKTGFDIPTSVKWEAHSRIKVSKLHYTWILKNISVANGVFENEFNKSVDITEYFTEDTDINLQLFKKGNLGECSLQFGIEMTKLKKNYFWIAVVHLMDAGGSVALSAQGEYLFYRSNEKLLWNFPLISKDKICINKKLCLPNNQLTLRCELSFADNNKLETFEFRETNEQESTTMDKQSDLQEVWIKNMQLCYKEGKFGDFIIRTPNRQFLVSRNILSAHSEVFDAMFERDMKERKTGIVDIEDLEDDTVSNVLKYVYTSTPDYTDYGIEALQKSVRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJR3</accession>
    <name>A0AAV6VJR3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000076">
        <property type="protein sequence ID" value="KAG8195933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJR3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8343" checksum="B1C5253616003B94" modified="2024-11-27" version="1">MCQNSRSPVPILSSHNVFMQSHSRVHNVADDGKNDKAFTAVVAPESSCSTMVGNASTMAERKSAEPKQNLQMRTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLC7</accession>
    <name>A0AAV6VLC7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial ribosomal protein S18C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_023206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000065">
        <property type="protein sequence ID" value="KAG8196697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLC7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8196697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="16347" checksum="D1ED3E95503730C0" modified="2024-11-27" version="1">MNLFNIPRFLLKASLKCPSLISRHSITATRSITSDKKDEDMFISDIPNPFEAKPRVCIACKYKIPLDYKNPRLLSQFISSYTGFVYDKHITGLCDAQQKRLITAVKTARMFGYLSWYLKPKKYLRDPKLFDPFAPSRPNPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLN4</accession>
    <name>A0AAV6VLN4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_014505</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000064">
        <property type="protein sequence ID" value="KAG8196772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06705">
        <property type="entry name" value="PDZ_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05609">
        <property type="entry name" value="STKc_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1480.20:FF:000001">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000008">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037711">
        <property type="entry name" value="MAST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF414">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08926">
        <property type="entry name" value="DUF1908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140482">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="538"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="813"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="17">
        <location>
            <begin position="1091"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="890"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1056"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1183"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1413"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1811"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="890"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1067"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1186"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1218"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1241"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1291"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1329"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1356"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1433"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1456"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1811"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1825"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1878"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1889"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1923"/>
            <end position="1987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8196772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1987" mass="219832" checksum="9EDFF81680D8B82E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM43</accession>
    <name>A0AAV6VM43_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_011298</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000058">
        <property type="protein sequence ID" value="KAG8197135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM43"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000193">
        <property type="entry name" value="Zinc finger protein 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF58">
        <property type="entry name" value="ZINC FINGER PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="394"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8197135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="502" mass="55550" checksum="863D32F3F31E9DC7" modified="2024-11-27" version="1">MKEGSEGGGGSDGIPTSRDADSTVFNGIVNGPVSVVASQPRRLLSDRPPTMGVTLASLGAEVASSALALSERGGLPMGGTTLANALLGITMDISRSSNGSSGNGETMAGGIHSTNSNNGKAMKNDSNQKRDKEFVCNICNRSFGYKHVLQNHERTHTGEKPFECKECNKRFTRDHHLKTHMRLHTGEKPYHCSHCERQFVQVANLRRHLRVHTGERPYACKLCCSRFSDSNQLKAHVLIHQGVKPYECLKCSGRYRRRHHLVHHKCPKDEANMGKPRRGRRPKAYEQLPTSMPMPSPVLKERLSTPVADLFSPPVPPPVTMTSVIQRNNHSPPMQQPPAAHMHQAMRNHIFSLQHHLGLAQNSNGRFHHDIIQSGPLDMSVSSAVAPNNSVSVIVQGPRNNNSYRHHNSGSHVDRALDLSNSRSDSEAEPIEEEVDEEDDLLDDGLDSESDVEDERQEHLRLIACSWKVGHHDDHLRRGNNNGEKYDGEDSNMTALQLTTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPF3</accession>
    <name>A0AAV6VPF3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOST seven transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_029384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000046">
        <property type="protein sequence ID" value="KAG8197990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPF3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF2">
        <property type="entry name" value="RE59932P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043395061" description="GOST seven transmembrane domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="9">
        <location>
            <begin position="290"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="560"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8197990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="586" mass="67042" checksum="63F4DEB1037C6017" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VR32</accession>
    <name>A0AAV6VR32_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitoferrin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_021595</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VR32"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000263">
        <property type="entry name" value="Carrier protein MRS3/4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000029">
        <property type="entry name" value="Solute carrier family 25 member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF20">
        <property type="entry name" value="MITOFERRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="12"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="109"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="200"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8198347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37538" checksum="FFE17A28D87883EF" modified="2024-11-27" version="1">MEFDDYETLPSSSTATHMVAGSFAGIMEHCLMYPVDSVKTRMQSIKPHPKAIYRNIPEAFSKMIRYEGLFRPVRGMPAVMLAAGPAHALHFSCYEKGKRLLSGTENGVGSPLAQGLAGAISTLLHDAIMNPAEVVKQRMQMYGSPYRTCSDCFTKVMKAEGFRALYRSYTTQLTMNIPFQSIHFMTYEFCQDLTNHHRTYNPMAHMISGAISGAFAAAITNPLDVCKTLLNTQEQQVLNSLKIKEAQISGLFNAATTVYRFSGFKGYFRGLKARVIYQVPSAAISWSVYEFFKYTLVLKYQTQQHTYKPDHNPLIAHASSIENTGASSIGGIPVVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSX4</accession>
    <name>A0AAV6VSX4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 183</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000034">
        <property type="protein sequence ID" value="KAG8198873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSX4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026509">
        <property type="entry name" value="TMEM183"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20988">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 183A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20988:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 183A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="41130" checksum="38663CA71835A23F" modified="2024-11-27" version="1">MSKGGKKEARKNFEIESDIKLSDFANSSASGGRIRKSVGKNFIKNAKEITKNEEEEEILWYDRDLDEFEFLDLGNGVKKKQLKTKASSGESFKGPGIQFPIDVWYLIGQYVKPEDVKLFANICKDSYKVSRSFSFWMEMYRRFYKPVDHLPTRLQPECIEQEFCLKSSVIRALYLMYPKFITQLSSRLPNTDVVNELSNLCCSSMWRLQVNEKWVFHFKFQNVTHSSDTRITYRVAIKDLWTNHGEKQDVYVNHNPDAGCKILRFTSSYFMVVSQKVIGSRLSGVRISLAHDMRRHKLQLMFRHSNYNQSDNRSNMSKDNSGSYSDIVEFDAVENVMVLNWWHPQYPLGYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTE8</accession>
    <name>A0AAV6VTE8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000028">
        <property type="protein sequence ID" value="KAG8199326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTE8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8492" checksum="A7A39B4D1832D6FC" modified="2024-11-27" version="1">MECLSTSTHSVRPRTEGHTRAPIYPLQQKSDPNRCVHQPFKLERTGVSGYSSPPSVLSISTAEQVVEYDIMGGAGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VV79</accession>
    <name>A0AAV6VV79_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000012">
        <property type="protein sequence ID" value="KAG8200862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VV79"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="9782" checksum="CA6969C621D00960" modified="2024-11-27" version="1">MWRRAQLQDRRGYSEYREAKEKNPVHHHGSELPVRHHIRVFIVLPHLRRYDTDLLQDLPQFRVCVHVWCTLWGWHPPSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVG2</accession>
    <name>A0AAV6VVG2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_000575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVG2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF28">
        <property type="entry name" value="NEUROPILIN AND TOLLOID-LIKE, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="25"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="153"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="448"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8200497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="570" mass="65033" checksum="37F49A1B65E60B5F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VX75</accession>
    <name>A0AAV6VX75_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VX75"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10466" checksum="837B90D150BC4B08" modified="2024-11-27" version="1">MAQVNVVDTAVHLPTADIIPDQKGNGPRLLNLDTFSQRDERWILILWPWARICASGCSCPPVTLSGNFIRPSVYRKISPHFRNSVCRSDMDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYD5</accession>
    <name>A0AAV6VYD5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DDB1-and CUL4-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_022340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYD5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000492">
        <property type="entry name" value="LEC14B homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="453"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="495"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8200731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60466" checksum="112D6A2A6C81E0AE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W276</accession>
    <name>A0AAV6W276_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W276"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="11940" checksum="EF110B9E95AADD1D" modified="2024-11-27" version="1">MQTQKVMHPSYSIGPFTENKQAHSEIPDTFVIDFLIDYSRGQLPAAPCPLLFLSQQRPKGPPKLTGQCLCNRRCLIAPPRLKRSCYYTEAVHEWGMLVKEKTGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W3Z4</accession>
    <name>A0AAV6W3Z4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W3Z4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8202082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12836" checksum="A7218D687E670B40" modified="2024-11-27" version="1">MSLIRVSRVFRIFHHHLSARGKALLCLLEPASLSLKLRTNLRFMIADTASDIHEDLLDEELAIFSKRPTLRRFPKVRNFHQLSRALSTFYNLQISQTFHSSPDFPTLKCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDL4</accession>
    <name>A0AAV6TDL4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006531">
        <property type="protein sequence ID" value="KAG8155868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDL4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="157" mass="17899" checksum="C128F360CE1FA378" modified="2024-11-27" version="1">MSQSRVRRHNKRPVLRHACLIVEDKHILLSGQPGIPLDLSHVSPFQKKPFHHRGTPIHQMAPVFDIAPRNIGHKIKYETSPHRQTVLDSPLPRCYCSGRGNNKGRKDDNRVEFGPRARHSTHPPRTRCATITISHFPTEIISAMERPARGPDHSQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDY5</accession>
    <name>A0AAV6TDY5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006325">
        <property type="protein sequence ID" value="KAG8156103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDY5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8156103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="403" mass="45304" checksum="9623383BFC21CB95" modified="2024-11-27" version="1">MRRRDDDDVPSGRTNGPDDEATATGGRRTASDARPRCRATTTGRPASRRARDDATSGDETDRQTGRARATTGDDRTRARRRRRLRDVRKRGDVDARRGGEGRTRTRTDADGRGDSAQAATRARRADDGTARCEHTTRRTVTYATRRRARRRTTVRRRTGRHDATTTYDAADATRGRGCGDVTTLTTRAAREDDDATAGERDATRRRRRDGTDARRRRLPRTRAYTTQRARDESRRHSSERREREPTHGRSTDSDDAKSTRRDSQRNTRPRTTRTDDVQTRRTQGRTTAQTPSQDDDAIDAGRARAIADDIAGTTQRQTDAYERRRDAAPRADDGTTYYKTGRAYVRKRGRSLARTGSTDADDDSYDCRGRDVRVIRPAAGRKAATTRTSAAGLTEETVRRDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THT5</accession>
    <name>A0AAV6THT5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004251">
        <property type="protein sequence ID" value="KAG8171250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THT5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="149" mass="16489" checksum="CD9089DDCACDA01A" modified="2024-11-27" version="1">MNKQIYFGTDLPENGFSRQGRSFVPSLFSPFVVHQSAAVWSIWATSTRHSAVAPKVRGNSLMTDGDRETPAPLRVSGDPVRQAPCGRAEFKPPAARALGGDYDALVCRRLFTVRGESFPLVRNIQYISLITGLILFYPQRNSSNILYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJ86</accession>
    <name>A0AAV6TJ86_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003603">
        <property type="protein sequence ID" value="KAG8171743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJ86"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="119" mass="12973" checksum="DE2DDB376E466C02" modified="2024-11-27" version="1" fragment="single">PKKPHPPEEPPQTPFPPPSVKHPRGVFPNQWSSSRPSGEAGGHAQEWSKKGPGLTHNPPRGVAAPGTHKGLRGDFQYDRIDKRITRMLAEKPNMDYAGSNVNLVITSSNMTLSVMESGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJC2</accession>
    <name>A0AAV6TJC2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003360">
        <property type="protein sequence ID" value="KAG8171939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJC2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="98" mass="11230" checksum="761E1953C52AA1BA" modified="2024-11-27" version="1">MALYFYIRTTLPDSLTDGERIDRFLKDIKRVYPGVNGEPLKLKVLDEPTPESMGISHLMPKEKATTSQASLTVDTDDEDDDLTYIDNIDDDPDWDMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKT2</accession>
    <name>A0AAV6TKT2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002786">
        <property type="protein sequence ID" value="KAG8172372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKT2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="258" mass="27105" checksum="D8897CE63A775BC7" modified="2024-11-27" version="1">MGSALICPLPVSKTLSGATSNSSNVKCDKPYIPRSQVAYGPRRGIPIRVGETPTPPPKYLNKRPTRQRERVLLPSSSVSAPLLGVQASSEPEIPLNLNLPSTSSDISISIPGFNVSLDEKGPDGSAPPPDGSVPSIVISDTCDSTLVDEQISAKSLNAARSPVVSIDQGLVQESHLITSDPIIVSETCAPVVGLVPGVMADSSLFDSADTSRLDPTVVNPTVVYPIVVTLPLLLLTLLLLTLLLPMLSLILLLLPRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TL93</accession>
    <name>A0AAV6TL93_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002429">
        <property type="protein sequence ID" value="KAG8172737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TL93"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="506" mass="57229" checksum="F7C937523BA726A0" modified="2024-11-27" version="1">MKITFVNECGDSNLQLTKSWSSVKSVLCGDLLLNGSKQLLHLKDTSFYAWQDSCIISDLSSSNPVDILCQAQDSDVSMSRAIPGLLAKVQKGKSMIAEAESKISKKIEATLDALIRLKDCSSENELHHVSSFQESLVDIILHNDENFRTNKDVSVYTKTLKVLNHWIKCIDNRCIICWTFMNTDEKSIFNPTLLTTIPNQQIQSTQKLFILKCDSFTINDECRRDINPGEKFSVLASLDMPEFHVKDIEMAVILSWYKATSSEFENEIYLPMRDKTLTPHQMNLKAVVSAEHVFKTQLKDISTAEHLACMKVVQQRIVLQVFTLHSDVTQFENILLTTAYGAAHLLLLENSEVKCLVFKSANLPLFGVHMIFNSLSLKTLEIEAFTKDDNESSLLIQFLYQQLPEDIIILPQGTTLSEFHEHQHQAICTMKEEVDLLLSTISIHNVTEKMGPDNLPSLNEAGTVVIPKETFLRVRKALVKKECTTDNVVQEMTCLRFSNDKPMGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLR9</accession>
    <name>A0AAV6TLR9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002506">
        <property type="protein sequence ID" value="KAG8172643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLR9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043966933" evidence="1">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="113" mass="13049" checksum="E5B8EA40CA3230CD" modified="2024-11-27" version="1">MLLCSVVFVLSVSGSEKSSGYEVLYDCLHKHICDCNFGLEYQTCFYQLPKPIIDNFEKLAHQKFPEITNIRQSLYPVWHVLCKEPKEVFKYLSVLDQFPSLGDQKKGVSMIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLX6</accession>
    <name>A0AAV6TLX6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002578">
        <property type="protein sequence ID" value="KAG8172571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLX6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="12820" checksum="07299080A73E31D6" modified="2024-11-27" version="1">MELGETVDQSMKNACLRQLIEKLPNYDKEYVKAMLTSCGGRNERKEEEQRQSETERQERIEIQRLVTERIRLETERQVEMQRMETERFEKERAYELENYELLTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMG6</accession>
    <name>A0AAV6TMG6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_029439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010002416">
        <property type="protein sequence ID" value="KAG8172751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMG6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="79"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8172751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="322" mass="36781" checksum="19A67BD82892EBD6" modified="2024-11-27" version="1">MDKTGVERLLLVVPKKYRNDLKAFCHEGTSGHLGVTKTKDIFSRHFFWPQCYKEIEDYVRSCDRCQRVGKPFDKKKAPMKIVPVIQEVFSKINVDACGPLPVTPSGKRYLLTAMCLSSKYPDAVPVEDITSVTVVDALLQIFSRMGFPKVLQLDQGSSFTSALSTTFLEKFGIKVVHSSVYHPQSNPIERFHRTVKRVLKGLCLESGSDWEQAIYPALFALRTVTHESTGFTPAELVHGKNLRTPLTLLYEKWLDVEETEGEPVTEYVFSLINRMKRCQELAISKMEECQQKNKTWYDKRAVKREFRIGDLVLILLHLKATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMP6</accession>
    <name>A0AAV6TMP6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_001068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002226">
        <property type="protein sequence ID" value="KAG8172933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMP6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="690"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8172933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="733" mass="84901" checksum="D5C800CDA89C4CE1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMX0</accession>
    <name>A0AAV6TMX0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010002153">
        <property type="protein sequence ID" value="KAG8173008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMX0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF8">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="326"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8173008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="732" mass="84601" checksum="A3AF1F00D669127C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TN24</accession>
    <name>A0AAV6TN24_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002196">
        <property type="protein sequence ID" value="KAG8172961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TN24"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="172" mass="19605" checksum="7A9C9ED631BAF6F7" modified="2024-11-27" version="1">MSCHSSSPACDLVATATFMFHQSDLVPRRMVFTVVTDPSQQYVIEPLKDTCTFSYSDVVLNQDKMNNPIALPKVSRQKNNVFRVHVNHLREFLKGEFNRQHLQDARPAIGCLDVTTYLYLMELMPNVSILPPNLMEGKMECLELGKDPIVSGQLAGDRLFARLHYVTDDWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNF8</accession>
    <name>A0AAV6TNF8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002047">
        <property type="protein sequence ID" value="KAG8173126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNF8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9638" checksum="3A97D89705D7C685" modified="2024-11-27" version="1">MGPLCPLNVVPSVNFGLRGKRGLVRATYPFPSVPYQLPRWVMRQTMVVTGEGEIGVFKFRRGSLRNGYHIQGRQQARKLPTPGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TP14</accession>
    <name>A0AAV6TP14_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001779">
        <property type="protein sequence ID" value="KAG8173428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TP14"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="212" mass="22020" checksum="B693103225EA3056" modified="2024-11-27" version="1">MLLTNKLSDLGSNTLNDLINKLNESFAKIDGTNATPAGVNAMLGTLKDKVVKASELPTKVIEKAVVDVLVPALATVGTGTSKQVYTKADADTAFVQTSGLTNTLKTEVVKPAVVDVLVPALATVGTGTSKQVYTKADADTARTLALNTKVNVDGSNAGAIVNALTKDPTFINAAKIHANAGDAGFQSAVREVISQPYFDIPADDSTPITAYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQY4</accession>
    <name>A0AAV6TQY4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_002895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001286">
        <property type="protein sequence ID" value="KAG8174218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQY4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043978169" description="MD-2-related lipid-recognition domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="2">
        <location>
            <begin position="31"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8174218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="135" mass="15008" checksum="3F17ED9AA65C75CE" modified="2024-11-27" version="1">MCLVTAGKGCVAEMKAFLICLLACVALSTATKFEDCGSKQVTVKNVDVQDCPDGPERCTLEKDATKSISIVFEATNSSSRAIEVRLYSWQNTWPWQFDDDHHDGCKGYGLQCPLKIGDTYTGDFYIIVATRYYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TR44</accession>
    <name>A0AAV6TR44_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001338">
        <property type="protein sequence ID" value="KAG8174054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TR44"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="189" mass="22439" checksum="4B96F2DC32DB5ACF" modified="2024-11-27" version="1">MKLLFLIDRIDNLKSILILEDDNLKQMWKSRYWRKDATVRKHIHFVMVQRFLGERDVQASSEMLLFDCLNILENRKDLRDLWEKTNDLFKGANIADFLAHGNPILQTIGNILREEDLPSEFIGNIMELIKDVDAMRALSEMWVKTKLCKESKFLAAVESDEQDEHMDLRKRIKKCSRWKEYASLLPLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRY0</accession>
    <name>A0AAV6TRY0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001176">
        <property type="protein sequence ID" value="KAG8174622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRY0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="331" mass="38968" checksum="9B09BB5113BB86CF" modified="2024-11-27" version="1">MASLAGEKSAGNFSSSGEWNDLQSFKLACWGSNPENVLRLWPIVRKDALSEICSGRFRVRAVFLKRSDFWFKFWVCYLRLQMKQSKKVNDPVDVSKLLIFVMMKSNVGAARYLLDDSLVCHIPNLANRYLTRLRSKFDSTTFVFLVNHFNEEDSKTFLNLHSVECLLRCLTWPLLQFFLPLTELVWPGFDFDANIETLLKEVLMKIKQTKEPASYENIFKTLWVKTPIQYRLRFITNNTYIILSDLFSGYDLQQAMAELAKVGQENRIQLLDLFIENANVVMSLSVEDSKYRSFKTILEKYFADKLIENYEDCYKTMTYAYYEFDYFFFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSD2</accession>
    <name>A0AAV6TSD2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_017430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001132">
        <property type="protein sequence ID" value="KAG8174835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSD2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015889">
        <property type="term" value="P:cobalamin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002157">
        <property type="entry name" value="Cbl-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051588">
        <property type="entry name" value="Cobalamin_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559:SF18">
        <property type="entry name" value="TRANSCOBALAMIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559">
        <property type="entry name" value="TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01122">
        <property type="entry name" value="Cobalamin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043596764" evidence="9">
        <location>
            <begin position="21"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="640"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="851"/>
            <end position="853"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="610"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8174835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="874" mass="99374" checksum="2BD77A56A2B37EB6" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TT25</accession>
    <name>A0AAV6TT25_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_024233</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001145">
        <property type="protein sequence ID" value="KAG8174767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TT25"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004995">
        <property type="term" value="F:tachykinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001681">
        <property type="entry name" value="Neurokn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043809440" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8174767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="176" mass="19826" checksum="03FBB0B46967BD40" modified="2024-11-27" version="1">MMITVVSVFTLCWLPLNALIVAGDEHDSVWQFPHIVYIWFVCHWLAMSSTAYNPLIYCWMNSKYRDGFIHVFRHLLPCLSLSSKRRGMTFNSSINRNGFNRGTNNTIYTSIRSSGCRTSQISRSLVLVKGHHKVCARTDSDRTVQVVGTLSKTVKIRNGNSEASTGLDSAMDSTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTJ2</accession>
    <name>A0AAV6TTJ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_021969</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001102">
        <property type="protein sequence ID" value="KAG8174971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTJ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005041">
        <property type="term" value="F:low-density lipoprotein particle receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000045">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF5">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043451033" evidence="11">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8174971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="209" mass="23569" checksum="4F500D8D05C2BD0B" modified="2024-11-27" version="1">MLWWNFSILILILFVQLIAGSKCPENGWIDCGNGKCVAQIWRCDGDNDCGNLKDEENCQRDIKPKPCPGFQCVEDGHCIPETWHCDGEQDCGDNSDELGCDGETLDYPCIGFRCKDRHCIPETWRCDGRMDCPDESDEEGCPIGFQAISLKTNKYEGFLESLGQKTNALPTELLQLFCVFNLNIIGYIVRICRGDTLPFSYAPGSWYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUD0</accession>
    <name>A0AAV6TUD0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Myosin-VIIa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_005242</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000973">
        <property type="protein sequence ID" value="KAG8175650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016461">
        <property type="term" value="C:unconventional myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17092">
        <property type="entry name" value="FERM1_F1_Myosin-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17093">
        <property type="entry name" value="FERM2_F1_Myosin-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd13198">
        <property type="entry name" value="FERM_C1_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01381">
        <property type="entry name" value="MYSc_Myo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000013">
        <property type="entry name" value="Unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000075">
        <property type="entry name" value="unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000036">
        <property type="entry name" value="Unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000051">
        <property type="entry name" value="Unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057130">
        <property type="entry name" value="Myosin_VII_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041793">
        <property type="entry name" value="MyoVII_FERM_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036106">
        <property type="entry name" value="MYSc_Myo7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF33">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21998">
        <property type="entry name" value="FERM_C1_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24123">
        <property type="entry name" value="Myosin_VII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="17">
        <location>
            <begin position="63"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="16">
        <location>
            <begin position="1013"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="15">
        <location>
            <begin position="1260"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="1568"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="16">
        <location>
            <begin position="1712"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="15">
        <location>
            <begin position="1866"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="12">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="883"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="156"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="2007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8175650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2007" mass="232080" checksum="6A4976A07231FB61" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUE1</accession>
    <name>A0AAV6TUE1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001048">
        <property type="protein sequence ID" value="KAG8175221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUE1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="200" mass="23335" checksum="BC155FA2319BB59A" modified="2024-11-27" version="1">MPYRETAMKYPKRRNGSEYYSNSAAEPFLKDENGRERYARDKNGNEIYPRRRHTLFSRNEEGQEYYARDKNGNEFYPCLNGQSVVIPERLAKFANNTQRYPSDAKGNEYYLQHQGKPYLLRQESGETYWAKTRKGVPMIPWNELQVTDNRPYVCTRDAVGNCVYVHETDLPPSLQSICNCLCHCTTICPKVLDLLLKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TW67</accession>
    <name>A0AAV6TW67_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neuroguidin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000896">
        <property type="protein sequence ID" value="KAG8176310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TW67"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34910" checksum="302E190FFDD1CEDE" modified="2024-11-27" version="1">MDVNPSDLNLEDVQEALKLVKEVPTLATNVSQTVQNILEKFQNNELETDKGLSFLDLKNHALLNYVMNLTYIILQKLTGKKIENCSAIDRLVQLRIVLEKMRPIDEKLKYQIDKMQSAVVNGSIDSTDPLRYKANPDSLNVEDEEETQEKKKESDIYVPPKISAAYYDEDNTLEGRKKKILERSQKRALSSSVLYELQKEYDTGPEEIRETIDPYKIKLNQEMKERERYEEEYMLRLPMTKKQKHESRQLLTVTNFDAKFDDISALEMESNDVSLKKRSSGKKSKLSKKYGKKKGKKKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXL5</accession>
    <name>A0AAV6TXL5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000849">
        <property type="protein sequence ID" value="KAG8176752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXL5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19152" checksum="3533A6985BC63269" modified="2024-11-27" version="1">MIVSNNFEFTMEGKKNDIISTLNTVDKAIIEEKKRKLVPVIKTIIFCRVQNIPLREHRDDGSLAESSNASTTEEVEDLTGGGLCKVVLVELQNPCLDISNCRGQAFDGGSNTSGKYQGLQARIAKIQPLAIYSHCANHRLNLVISKASSTPSIRNAVGGISSVAIFFENLLRGCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TY90</accession>
    <name>A0AAV6TY90_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleosome assembly protein 1-like 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_006521</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000825">
        <property type="protein sequence ID" value="KAG8177045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TY90"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8177045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="39918" checksum="90893F2DC0C8EDBC" modified="2024-11-27" version="1">MANLLLSNPLYSLPKSVRRNVLALKNLQLQHVHTEVEFFKELHQLEMKYEKIFEPLYEKRAAIVSGAVIPTEEECKFQNETEADISNELEKLKGDTETDNEKTEEPDIKGIPEFWLTAFKNAPAVADMIEEYDEPILQHLTHVKAETSFEPMSFNLEFHFEPNEYFTNTVLTKYYEMRCTPDESDVFAFEGPEIVKCKGCTIDWKKGKNITVKTIKKKQKHKARGAVRTVTKTIANESFFNFFAPPTPPENEDDMDEETQSILNNDFEVGNLIKDRIIPHAVLFFTGENLIDDDFDEEDEDDEEEYDEDEDEESEEDDENDSSTRKKSRGQTGDKTQAPPECKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U034</accession>
    <name>A0AAV6U034_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000778">
        <property type="protein sequence ID" value="KAG8177458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U034"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47456:SF5">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47456">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14641" checksum="AEBBB577413E8EB8" modified="2024-11-27" version="1">MKQDNSCEALHIIKSWNPNGNPCYGMVDFAAEEIGALETIFPGILVFICSFHREQAWNRWYSKYQNVTVPKAEALARLREVANAGTEGELQDALTKLKSWEYYNFTPLKDYFEKAWFPEIKRWALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4K3</accession>
    <name>A0AAV6U4K3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_017604</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000660">
        <property type="protein sequence ID" value="KAG8178907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4K3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8178907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="531" mass="57714" checksum="663AABF261806970" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U692</accession>
    <name>A0AAV6U692_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000646">
        <property type="protein sequence ID" value="KAG8179154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U692"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7519" checksum="07D14C84D0B002B5" modified="2024-11-27" version="1">MCAMKVDVAWSPTEINRFITIGTDVQLYEVEDVTERNVKPPGISISENTFANVISTSSEHQYLKVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6E6</accession>
    <name>A0AAV6U6E6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposable element P transposase-like GTP-binding insertion domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000606">
        <property type="protein sequence ID" value="KAG8179729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6E6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="1">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="124" mass="14278" checksum="5AE29F21151A107F" modified="2024-11-27" version="1">MAKCLGATLEHPDPVLWFPHPADPQENVHIILDVCHMLNLIRNCWATLKCFKFDGRRIEWRYINYTRYKKRKMIKRVPPSSDPALDFAVLPDSHPAVPAVVQEEFVALPCEQPPVITTESKCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBH5</accession>
    <name>A0AAV6UBH5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000490">
        <property type="protein sequence ID" value="KAG8181887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBH5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="10675" checksum="804342966FCF4461" modified="2024-11-27" version="1">MGYSEIHRQNWSSLEVHREGSVTYLCCPQDRWAFEDGHQKRGGGGGGRRDMSLVSIYTSATQRCGHQNHTISFHPKYGHTPTEDHRIAAFDCPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBL9</accession>
    <name>A0AAV6UBL9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000533">
        <property type="protein sequence ID" value="KAG8181123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBL9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11796" checksum="A693E35EDFB4C232" modified="2024-11-27" version="1">MKISFRHLQLFTVCKDRAPASGLNRSWVFNNKIEKISLQKFLFLAETGLGRFQFGANGGRGARYLTHFHPAIPFGRRHSLHFCARFLQTTSSSVKPLSTRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UC70</accession>
    <name>A0AAV6UC70_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_018081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000497">
        <property type="protein sequence ID" value="KAG8181774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UC70"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="133" mass="14923" checksum="E739E0FFE2E0B75E" modified="2024-11-27" version="1">MKTFNAKHNEKSPTLSSPVASVSPANPKTDDRKNKRRKKKRIKKVPKKTGQNNGMDNTSLEDLRLSARTEFEHERDMLLTTLASVVKIICFLRERENGRAKSLFGILSSLVGIACCALFELTASFNQSIDRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDB8</accession>
    <name>A0AAV6UDB8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000493">
        <property type="protein sequence ID" value="KAG8181853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDB8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="9207" checksum="4FD1423DADDB3268" modified="2024-11-27" version="1">MAKLTKEVHTKNLSGHSRNRCLTTDLQQKADCFCWSHWSKTSGGEGMPPPFTVQIETLKVRNCWDVREENNFFLDACYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDT0</accession>
    <name>A0AAV6UDT0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000483">
        <property type="protein sequence ID" value="KAG8182013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDT0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="143" mass="16724" checksum="87CCBCD79ABDD0D9" modified="2024-11-27" version="1">MDTEIVYDVMDPKDIKIEMVEPQSENIAKPAITRNATKVNSRKSKSRQQSFKLFILRVKKQILLKESVGKLAMEELDNFLVHMMKQLKMELFWMNHVNNNMTVTPQQLEYAFKLCFPPRLAAASNEYGRMAVQAYFDCLESER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UE92</accession>
    <name>A0AAV6UE92_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thyroglobulin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_003982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000493">
        <property type="protein sequence ID" value="KAG8181835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UE92"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF3">
        <property type="entry name" value="NIDOGEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043899513" description="Thyroglobulin type-1 domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="85"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="114"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8181835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="145" mass="16404" checksum="4F187F41AA8F2598" modified="2024-11-27" version="1">MKCVLLILVVVVAVAWARPQSDCEKHRENAQKIPTIMKLIPKCKENGDYEELQCYEDSSFCVCYDKKGHPASPISSKIKECGCNLKRKQKIDSGHDNPYIPQCEDNGKWAKKQCWDFNKSCWCVDEEGNNPTGKISSDGSKLVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UG86</accession>
    <name>A0AAV6UG86_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000445">
        <property type="protein sequence ID" value="KAG8182843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UG86"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044011962" evidence="1">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="162" mass="18514" checksum="DC8DE0E9F5D512F1" modified="2024-11-27" version="1">MRNIRISILLLRVSLVACAWTLTLGQGGVITPRYAILQRTHYEWLPQITDYDMDQAFVVAEHVIKAKRAHEEKIFKGGRIMQPGQYPSSARHQHLLAPNKKASKMERATEKFEEATNVIKDMFTSPKKHVLKPPTRMKVPSLKAALPGGLPWPLQCWWMPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGJ9</accession>
    <name>A0AAV6UGJ9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_017668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000452">
        <property type="protein sequence ID" value="KAG8182690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGJ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF60">
        <property type="entry name" value="RH50, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="7">
        <location>
            <begin position="60"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8182690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="511" mass="55926" checksum="EBB142AC95B89AEA" modified="2024-11-27" version="1">MFHDVRTTGNQSTVSKNIATIADKENMPMPHATSVNPLIPKMAANSRKFAIVVIIIQIIFIICFAFFVEYGEDMDAASPKNFYLDSSKAAESNLHQYYPMFQDANMMIFFGVGFLYSFLAKYGYSGVGLNFIISAVAMEWSLLAHEWWNSVNGKIRIDITSFISGEFSAASAVIAIGGVFAKVGPLQIVVFTLIEVLLYTANEHFCVTAFKISDVGGSVSLHMFAGIFGCAAAYTLDKGSVVQNNPNERTSYSSNLFTMVGTLLLWAYWPSFNAALSSSGNLQYRSVVNTYLSLLGSCVAVFAVTTLIQEEKKFTMSHIQNATLAGGVAIGATADLMVQPYGALLIGSIAGTLSVLGFQHFSPFLAKFKIYDPCGINSLHAIPGFFAGISSIVLAFMATEEKYGHNLYKLYPAMAPYSNTSSLIEIQSHSPDVQPGFERSPQMQACFQFLYVVEVMAAAVATGLATGFLLRSKMFDPLEEKHMYLDEVLWVMPECKEKTKTTSINNSTSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIJ3</accession>
    <name>A0AAV6UIJ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000391">
        <property type="protein sequence ID" value="KAG8184011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIJ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="11171" checksum="20820A1E0D10E010" modified="2024-11-27" version="1">MKSCQQWTACSQQWNITPLSPRSPSRNAIPFGETKRKPEMRTLRKLDISFQRKTGRAIFEKEMARISQSGSRNKHRKEWTGIFGARYYLFYRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJM2</accession>
    <name>A0AAV6UJM2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000372">
        <property type="protein sequence ID" value="KAG8184452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJM2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="220" mass="24414" checksum="77FCD4058D3B35F2" modified="2024-11-27" version="1">MISVENIASELCNFKQQSCDRFTSLEEMIIQSKPGINKVVDADVNVPSANLVDNIDKNGFTTSSGKTFADVVSLSDPKTLPLNQVNKRGQQSTPKPVISGTSKISKLMPATRFPRRAAAFVSRLNPSTQAIEVQDFLSSLKLSHLKCVKMKTKFNSYSSFHIEILESDLQVLLDDGLWPEGCIIFKFFGRLKQDQILMDPNVNDIRNSSSSMIGDGHRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKL1</accession>
    <name>A0AAV6UKL1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">JTE90_019357</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="JAFNEN010000363">
        <property type="protein sequence ID" value="KAG8184761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="25">
        <location>
            <begin position="45"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1162"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1168"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1173"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAG8184761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2070" mass="228121" checksum="2ABD0F10353CF898" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKR5</accession>
    <name>A0AAV6UKR5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000359">
        <property type="protein sequence ID" value="KAG8184821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKR5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="175" mass="20046" checksum="E77A8D35A93CF8C3" modified="2024-11-27" version="1">MGKANDLDYEELLVTYNKLARFVEHIDNELSIFVIFGTLFNSGIMYHFISSFLHINFLSGWHYSTFLKLFCFNSLLSLFAFTATAAMVNEASIEIATYAWTMRTSDIHSAMSLQRFQFRVAQQIYLTIWKTSPIRRGFFIKIIGVIFTYALLVDQLNPSQSAITVHLNSSASLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULV4</accession>
    <name>A0AAV6ULV4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000341">
        <property type="protein sequence ID" value="KAG8185269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULV4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="157" mass="18562" checksum="2E57B5E15D9496EF" modified="2024-11-27" version="1">MADVVRSRSSHSKNSRGRGKDKYKDRKKDSPRKKHRFDNGRSTKVSTPKDYDRKFEDHSSSRHWEDCRDSHKKFDETVYSRPQYDCYKDESLLNNHAMLNGQINFGDRFNNHVSGEYRFNSNDNLNGESAASLKADIVDLRKQVEFFYQENILIVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMR8</accession>
    <name>A0AAV6UMR8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_017043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000349">
        <property type="protein sequence ID" value="KAG8185019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMR8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="136"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8185019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="331" mass="36262" checksum="86EC3E919102E6E9" modified="2024-11-27" version="1">MGVIEFRTSFIPHVRSNHHLDFRTSSTKGTKWTGAFCSIASLSCAPPQKNNKIRTISDKRLLEQTVTGSVRCKMHELNLKGTHHQSSGFVFVSGGRRLASNFDSRTEVSGPGGLTLVIPWVVTQEVDGLKKSPGGLTLVIPWVVTQEVDGLKKDPSVGTQAQVSARFLSGYINKNISPVNVIGQSRLSVKNLERRWWVYRRNNDDRIIDLCVDMSEGGLNIILYSEDNGITAKAIIEGLKCARRLSLWPGPSGQAPRLQSRPRYTTGTATIEAGRSGPSGQAPRLPSRPRYKTGTSTIEAVALALVARLHASHPDPGIKRALPPSRRSLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNW6</accession>
    <name>A0AAV6UNW6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 19">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="13">IMP dehydrogenase</shortName>
            <shortName evidence="13">IMPD</shortName>
            <shortName evidence="13">IMPDH</shortName>
            <ecNumber evidence="13 19">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_023911</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13 19">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13 19">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13 18">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="13 19"/>
    <dbReference type="EMBL" id="JAFNEN010000341">
        <property type="protein sequence ID" value="KAG8185303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNW6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 19" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 13 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 13 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 13 19" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="109"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="174"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="13 14">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13 14">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <begin position="269"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <begin position="319"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="359"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="382"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8185303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="512" mass="55362" checksum="695457FD7231EC80" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPF2</accession>
    <name>A0AAV6UPF2_9ARAC</name>
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        <recommendedName>
            <fullName evidence="3">GMP synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_023289</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="EMBL" id="JAFNEN010000330">
        <property type="protein sequence ID" value="KAG8185589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0AAV6UPF2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000008">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000044">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Class_I_gatase-like"/>
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        <property type="entry name" value="GATASE"/>
    </dbReference>
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        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
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        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
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        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 11" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="12">
        <location>
            <begin position="238"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="265"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8185589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="715" mass="79010" checksum="1B1B14880E008F7C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPF3</accession>
    <name>A0AAV6UPF3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000330">
        <property type="protein sequence ID" value="KAG8185578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPF3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="723" mass="81969" checksum="4662009144419035" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQU1</accession>
    <name>A0AAV6UQU1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_019931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000296">
        <property type="protein sequence ID" value="KAG8186610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQU1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21989">
        <property type="entry name" value="HMG-box_HBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049523">
        <property type="entry name" value="BBX_HMG-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052412">
        <property type="entry name" value="CC-Dev_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059:SF10">
        <property type="entry name" value="HMG BOX TRANSCRIPTION FACTOR BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059">
        <property type="entry name" value="HMG-BOX TRANSCRIPTION FACTOR BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="41"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8186610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="720" mass="81295" checksum="B1C0B26424BD846F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URD2</accession>
    <name>A0AAV6URD2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bardet-Biedl syndrome 7 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_024118</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of BBSome complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000287">
        <property type="protein sequence ID" value="KAG8186876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URD2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016575">
        <property type="entry name" value="Bardet-Biedl_syndrome_7_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056334">
        <property type="entry name" value="BBS7_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056335">
        <property type="entry name" value="BBS7_hairpin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056333">
        <property type="entry name" value="BBS7_pf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056332">
        <property type="entry name" value="Beta-prop_BBS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074:SF4">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23360">
        <property type="entry name" value="BBS7_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23349">
        <property type="entry name" value="BBS7_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23361">
        <property type="entry name" value="BBS7_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23743">
        <property type="entry name" value="Beta-prop_BBS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011091">
        <property type="entry name" value="BBS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="BBS7 beta-propeller" evidence="6">
        <location>
            <begin position="23"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 GAE" evidence="4">
        <location>
            <begin position="378"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 platform" evidence="5">
        <location>
            <begin position="495"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 helical hairpin" evidence="3">
        <location>
            <begin position="600"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="335"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR011091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8186876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="717" mass="80649" checksum="D53A2C6810743D8C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URX0</accession>
    <name>A0AAV6URX0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000303">
        <property type="protein sequence ID" value="KAG8186398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URX0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11825" checksum="819CE7F401DCE429" modified="2024-11-27" version="1">MGGWSLFNNSYILSNPLVQWDTSIVVLDSEKVSYNPLKRLTVQRVKDLLSTEIYIINTHEVSDYRTFYFFAVGDTQSAGEKRGRWVSVHLRRGLDGIGEEKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USN2</accession>
    <name>A0AAV6USN2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000291">
        <property type="protein sequence ID" value="KAG8186748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USN2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7723" checksum="A075F4A0111A0B72" modified="2024-11-27" version="1">MEVATAGVAVVWCSGHQASQLCCRHEFECELDIWSWADQVFRLSWVYEQVPNLLETLFVELDLVSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USP2</accession>
    <name>A0AAV6USP2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000289">
        <property type="protein sequence ID" value="KAG8186789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USP2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9733" checksum="133E8D6654834CC6" modified="2024-11-27" version="1">MSTTRLHKRVPNITLYVICETLPYRVVLCIVGGRGSVITLGGHLAPPPPALSVCYILWHPWREKFLYGGRGCHFFVMEGGRCEKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UT84</accession>
    <name>A0AAV6UT84_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Growth hormone-inducible transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_009534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000272">
        <property type="protein sequence ID" value="KAG8187465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UT84"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10431">
        <property type="entry name" value="GHITM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035871">
        <property type="entry name" value="GHITM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8187465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="36007" checksum="DB4B264F908F21EF" modified="2024-11-27" version="1">MAAALFIVRPTLHLLNKNACLKTSLLSVKNSMANQSKTYANEGRSAFRRSRLSTRSPTLKERLMAPQQGTAINLGQGLLLGASAFGIGSLCYYGLGLSSQPGAVEKSMIWPQHVKDRIKSTYAYFGGSMIITAASAYAVSQSPKLLNLMMRNSWLAIGATFAAMIGSGMIVRSMPYTEGISGKHLAWLAHCGIMGAVVAPMCFIGGPILMRAAWYTAGIVGGLSTVAACAPSEKFLYMGGPLACGLGVVFAASLGSMFLPATTALGAGLYSISMYGGLVLFGAFLLYDTQKIVHKAENYPVYAYRPYDPINASISIYLDTMNIFIRIATLLAGGGSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUS4</accession>
    <name>A0AAV6UUS4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000251">
        <property type="protein sequence ID" value="KAG8188050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUS4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="250" mass="28991" checksum="9CC7838D5FBEA914" modified="2024-11-27" version="1">MSLEWFKIILFGDSLVQRSFEPNNGLWGTLLANRFQRVCDVIPRGFGGYTSRSGRIVLPHIFPENLSNVEAFIIFFGANDYSGVDDPSGHHVPLEEYSENIKNMIKYIEKIGVAKDKIILISPGPYCDEKWLKFCEQLGRTFPKREKELAAKYAEECQNIAKELGVDIVNIHEEFMKDEDWPKYLLDGVHLSREGSFLVYELLMQILEKRMKMSELLMPYWRDINHILPANATPELCLQKSVSYYFPVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UV09</accession>
    <name>A0AAV6UV09_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_029076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000248">
        <property type="protein sequence ID" value="KAG8188151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UV09"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8188151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="755" mass="86177" checksum="C5B8E452D29461D5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXW8</accession>
    <name>A0AAV6UXW8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Actin-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_019072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000218">
        <property type="protein sequence ID" value="KAG8189315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXW8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000538">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8189315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="44544" checksum="1EAF7A3186C7A09A" modified="2024-11-27" version="1">MDSQGRQVIVCDNGTGFVKCGYAGQNFPSFTFPSLVGRPIIRAAHKIGDIEVKDLMVGDEASKLRSMLEVAYPMENGIVRNWDDMCHIWDYTFGPSQMNIDPKNCKVLLTEPPMNPLKNRQKMIEVMFETYEFAGSYIAIQAVLALYAQGLLTGVVVDSGDGVTHICPVYEGYALSHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYIGYNIEQEQKLALETTYLVEPYTLPDGRVIKLGGERFEAPEALFQPHLINVEGQGIAELVFNTIQAGDIDIRPELYKHIVLSGGSTMYPGLPSRLEREIKQLYLERVLKGETEKLAKFKIRIEDPPRRKDMVFIGGSVLAEVMKDKDTFWLSREEYLEKGLNVLEKLGAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYX9</accession>
    <name>A0AAV6UYX9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000213">
        <property type="protein sequence ID" value="KAG8189546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYX9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="11335" checksum="CC9879AA0A8007D2" modified="2024-11-27" version="1">MCGWRHPHACDVRLEKTARLRCAAGDTRTPAMCGWRHPHACDVRMETSARLRCAAGDIRTPAMCGWRHPHACDVRLETSARDVDVVDICRDVDVETYVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZ04</accession>
    <name>A0AAV6UZ04_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZ04"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10128" checksum="F100D63953E2655D" modified="2024-11-27" version="1">MVDVINNHGLLYKCSLHFSIIGLILLNLKSFVFCRPRGVAVFGGGGSGHYAEVSENWGVLSQPTKVLLYIFCAIICILLAIGIYRLVKWCIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZF7</accession>
    <name>A0AAV6UZF7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Deubiquitinating enzyme A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_018464</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000220">
        <property type="protein sequence ID" value="KAG8189173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZF7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF4">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="46"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8189173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="209" mass="24417" checksum="F866DDB6EACBF890" modified="2024-11-27" version="1">MDKSLTKPLTKRRRRTKPKPLVYINSQSNKRKLNPNKFNHSRDGTFRIYPMREDGNCLFRAMAYYVLGNQKENGFVRHLIARHISRNFSNYIDFIGEEHAIYLQRMYQAGEYGGHIEILAFTEIFGCAVDIYHQDHPDDSPLRVGSASEALPLIYCGITDSGHYNVLLPLSTPNLDVESHKDYIRRLRERSCRRFGNSMENFKVLEKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZI1</accession>
    <name>A0AAV6UZI1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_009072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000199">
        <property type="protein sequence ID" value="KAG8189930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZI1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8189930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="162" mass="17975" checksum="CEC7C43E7F772A4E" modified="2024-11-27" version="1">MITAGKGHIVAVSSVAGLRGWLYLADYSASKFAVHGMMEAMEEEIRILGLTNTIHFTTACPMTIDTGMNQNPTTRMPCLAPILNVAETAEVIVNAVLMNDRIITVPRKLLFPLLFVRLFPRKVAQQVFDFLDYNTKPNRPNRGEQQGTMSHEQSNSVNIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1I3</accession>
    <name>A0AAV6V1I3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SKP1 component POZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_022480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000207">
        <property type="protein sequence ID" value="KAG8189665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1I3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="4">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="310"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8189665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="441" mass="53332" checksum="0A3346751F2DF88B" modified="2024-11-27" version="1">MGYHQKQARKYRKGNREFGLILNMHFVKFKSSDGIIFELDKNAIEMSATFCTMVDALGDKDDGVILLNKFNSTILRLVVDWMNHHVDDPFPDDERRIEGFRDDYYNSELYDYDLELLKDCSIHILFQLSLAANYLEVDGLMVFASMGIANILKAKNLLHLKPKIDSCIRRLHLKVTEDMSAESEEMIEYHKAVEEMQVLIDEIVEFQPRVNYQLHCNNRKLTKEEEEEEKEFAERVAEMQNDIDEVIELDPVNVQRLAASLSIDETNNTTFAFREQADTANGESYEWYGVDWQRRIQETQEKEWLHIVQVKEWQRKVEEMQEKERKFHQEMEEERQRRVHYEEWQCRVQDEELQRKVKKMQEVIQKFLQEKEVERQRRVQYEEWRRRVQYEEWQRRVQFAAWQRGVQDAIEWQRKVEEMRVEEQKILQEMDEEELHMLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V201</accession>
    <name>A0AAV6V201_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000195">
        <property type="protein sequence ID" value="KAG8190067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V201"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="209" mass="23436" checksum="60D6045EC0F0F6FF" modified="2024-11-27" version="1">MTCPSLIACCFLYRGITVRGADNEGWGRPTPLHLSSERTTSVRGAVLLRGILTSPKHQRIQTQHGRFPFPLEPEVFSVVQQQQTPMHTTSSLVSIINCPRDAFGRQSNNPPRNYVLRDGVVQIDGMHRPEVLSVVQQHQPPMHTISSLVSIINCPRDAFGRQSDISPRNYGLRARGGRNKSMEWYGMVRGDPNLKKRSTRSTHDLLIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V540</accession>
    <name>A0AAV6V540_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000152">
        <property type="protein sequence ID" value="KAG8191789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V540"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="41697" checksum="65AA361D8B0F0847" modified="2024-11-27" version="1">MSKAENLQCVPEREFLARWRIKNASMFGIKENQSEISPTFKVPFLGNTKWYLKLLFRLPGKRNIMCFLWRNTDDEGPEYVKVYYSISVGSSYSAELQTFSKNSRSFNPRLIDQDEFHEKVFRGNSKDVLQIECRLWPDSGTEVLIPTSPYPVGIEMVTTIQKETRSIFQKIPDFSKFREGQVIAFHLDSAESADSVPKLICRLWMKQQTTKVLLHEAADNLQFDIMLKCNVRLLDAFGVRHSLYHGSAVFHERSTNTMNFHFALSNEQLMEKKDLYLPGDELLLHWEFAYTSNKNIASFVERTLYDETSDLQVKRELKWGIYLERKYNEHRLFFRLLAFLAVVLSVLPHLLYDNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5W3</accession>
    <name>A0AAV6V5W3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000150">
        <property type="protein sequence ID" value="KAG8191872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5W3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043697812" evidence="1">
        <location>
            <begin position="24"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="163" mass="18385" checksum="3C60D60A20B07B1F" modified="2024-11-27" version="1">MFSMKIIYLPSLIIAIILKYSESEFLYYSETSINNIFDEISNLTPSKNSENFNTLSFVDDTIEITVPNGTEFESSDLAIDLSNQSDTNKFSETVTKGNIDHIKVEPLTSHLIEHASPLNDRASEKNMPDEMADNMSKGFFLLKNMQIKRSASSKDANLITEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6G4</accession>
    <name>A0AAV6V6G4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Arginine-glutamic acid dipeptide repeats protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_003272</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000162">
        <property type="protein sequence ID" value="KAG8191261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11661">
        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000052">
        <property type="entry name" value="Arginine-glutamic acid dipeptide (RE) repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.50:FF:000004">
        <property type="entry name" value="arginine-glutamic acid dipeptide repeats protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002951">
        <property type="entry name" value="Atrophin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859">
        <property type="entry name" value="ATROPHIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859:SF11">
        <property type="entry name" value="GRUNGE, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03154">
        <property type="entry name" value="Atrophin-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043720042" description="Arginine-glutamic acid dipeptide repeats protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="13">
        <location>
            <begin position="27"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="136"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="12">
        <location>
            <begin position="244"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="191"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="299"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="537"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="702"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="969"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1238"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="548"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="576"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="765"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="810"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="862"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="980"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1006"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1018"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8191261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1376" mass="151934" checksum="FFD6CAB18516768B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6S4</accession>
    <name>A0AAV6V6S4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycerophosphocholine cholinephosphodiesterase</fullName>
            <ecNumber evidence="4">3.1.4.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Choline-specific glycerophosphodiester phosphodiesterase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Ectonucleotide pyrophosphatase/phosphodiesterase family member 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="ORF">JTE90_017953</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41003"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:34071"/>
            <dbReference type="ChEBI" id="CHEBI:74344"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:41004"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28733"/>
            <dbReference type="ChEBI" id="CHEBI:75561"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:41116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41091"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:75757"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:41092"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41127"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74966"/>
            <dbReference type="ChEBI" id="CHEBI:75529"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41128"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:75542"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:41120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40999"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64489"/>
            <dbReference type="ChEBI" id="CHEBI:75536"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:41000"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36083"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15850"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:36084"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:44721"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>glycero-2-phosphocholine + H2O = phosphocholine + glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:144950"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:61685"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:19546"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>sphing-4-enine-phosphocholine + H2O = sphing-4-enine + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41095"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:58906"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41096"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.38" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000139">
        <property type="protein sequence ID" value="KAG8192419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6S4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047390">
        <property type="term" value="F:glycerophosphocholine cholinephosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF66">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE CHOLINEPHOSPHODIESTERASE ENPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00046203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00049092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="KAG8192419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="419" mass="48181" checksum="5125A145C4662214" modified="2024-11-27" version="1">MCIVRLYPESHGIVQNYMYDEARDDLFLMALHSNASHAHWWNDAEPVWVTAEKRDLKSAVYWWDGCQVLIQGKKPTKCEEYANYWVWGKVNKDTMNAMTETLDKFQKDSFRLGLVYYEAVDANGHFRGPGSEDRVRSLKDIDTILNNIQDEIAKRGMENQVNLIVVSDHGMTAIDGDAPKVINIEKSIDIKNIRLMLDRGAVSMILPVHGKEDKLYGDLKKANIQGLTVYKKNQIPDHYHFKKHKLVQPILLVADEGYVIKALSDPKKMKPYAERIFKGYHGYDPYKVKDMRTIFYARGPSFKKGFTSPPLEMVDHYNAICKAMGMVPLPNNGSWARTKELMTGNALRPETHVGPDKKPKSVKFNKNKSISSNKKKNVFKGKRKNSAHYNEGQQWNVIFASIFVVFIGRKLAQRNFFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V780</accession>
    <name>A0AAV6V780_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine repeat adapter protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM89 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000153">
        <property type="protein sequence ID" value="KAG8191743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V780"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039499">
        <property type="entry name" value="LURA1/LRA25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46949:SF1">
        <property type="entry name" value="AT07979P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46949">
        <property type="entry name" value="LEUCINE REPEAT ADAPTER PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14854">
        <property type="entry name" value="LURAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8191743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24566" checksum="16E9061144BED196" modified="2024-11-27" version="1">MRFTRVARLPSAPGDNLDDICYWVAESHTIPMASLQGLPPLPKSLSGLLNFSSAQWKEMERLHTMRTMIQQDLTRGIAERSNLQRVPSHSNSVENDPSDHGSPSESSGQSRAGRLDVQLALLRKEMVGLRQLDMSLLCQLWSLNESIHEYKQLMQDRMSVSLSPTHPSSPGWDNGLDSPSSEEHTNNKSFEHNLEEQNETARKLSSVDSGSHSSLEFGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V820</accession>
    <name>A0AAV6V820_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_026811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000152">
        <property type="protein sequence ID" value="KAG8191776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V820"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8191776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="177" mass="19238" checksum="4C445AFF19C370E2" modified="2024-11-27" version="1">MPILNDYSRDKDIRKDTEQYLIMGYIVFQMVGYTCLGWLVDKGFVEISNYVAANSLCMGLACCAMRFSSSFVALFLATAAFSTFLAALSSSVPTLVYEFIGKSLQSMAISSALVLLAPLSFSIAPLIGYFRGNLGSYDGGMYLMTAICVGCAVLIFMLPHIQKCGEKKKDNLSAAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8R0</accession>
    <name>A0AAV6V8R0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Anaphase-promoting complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_027770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000144">
        <property type="protein sequence ID" value="KAG8192123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8R0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000019">
        <property type="entry name" value="Anaphase-promoting complex subunit 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028841">
        <property type="entry name" value="APC10_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="8">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8192123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="179" mass="20800" checksum="E43C47E5174C14EB" modified="2024-11-27" version="1">MSFDPLKEEREGRVREVGAQAVWSLSSCKPGFGVDQLRDKWLETYWQSDGPQPHLVNIQFRRKTTIQYVYLYADYKLDESYTPNRISVRAGTHFHDLHEIEVTELSEPSGWVRIPLKDDDDQPIRTFIVQIAILSNHQNGRDTHLRQIRVHSPVENHCFAAIKFPMLTSIECASYSSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VA65</accession>
    <name>A0AAV6VA65_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000134">
        <property type="protein sequence ID" value="KAG8192849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VA65"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="134" mass="15223" checksum="A0F6075B7D31CA5E" modified="2024-11-27" version="1">MGDSYFLQPTLDSERFLEEASKNGCSKFVLLIEQSAGNGIPRNIPVALKAVIERKVANHKQINDLRFTRSNKIVVVTPNLEVQPARPEFDVSPEIYPYTSYEVVLDLHDSDYHSIIIDVDLNLKPLPSRRTTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAZ8</accession>
    <name>A0AAV6VAZ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000129">
        <property type="protein sequence ID" value="KAG8193130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAZ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="106"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="301" mass="35223" checksum="461BFEE9F870AD90" modified="2024-11-27" version="1">MLDRDPKTARIGEEILPFEIGHIPEYFQKKAEVELHETPEKIVQCTRKLKELAKRDDILCDVDFTDDILVQYLRMRKYDVDRALETLQTAVKFIRKYPENFCNFSFEETVKALTQHVLTIFPSRCQDGCAIFLIELDKWKLDQFSLREFKQLLVLVLFQALQMHPMTQVNGFKVIFDVKITSLRLLKILTPHNMWLLYHGTQECVPGRFKGIHIVNDSIVFKTAWLILKHFFSEKLKKRIHFHSSPKGLLDHFPKSVLPVSYAGEAEDYNPAQETWLKNVMTPEKLDKLGGGLFKNLEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VB91</accession>
    <name>A0AAV6VB91_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000117">
        <property type="protein sequence ID" value="KAG8193626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VB91"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="189" mass="21723" checksum="7CBB6019D74D4E06" modified="2024-11-27" version="1">MPLSETGNAYFNGPCKIAKEELQQSVERQPILWRNVIRGLFGYRDVALRVSDSGGIVFSAKRTQVLYFGQKPMDCLLSDSRTVLIKYFHPILTTIPHRQSKNEANKVNKPNQIHRTLEIKVPISWNRPSYRRVVDIAPAIAAAPFPTKSHFKPLGHYGERKVLLVANQEMPQRWDDKDKNESKFDTCFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBC5</accession>
    <name>A0AAV6VBC5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDP-D-glucose phosphorylase 1</fullName>
            <ecNumber evidence="5">2.7.7.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_022986</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30387"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:62230"/>
            <dbReference type="EC" id="2.7.7.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GDPGP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.78" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000124">
        <property type="protein sequence ID" value="KAG8193358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBC5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080048">
        <property type="term" value="F:GDP-D-glucose phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026506">
        <property type="entry name" value="GDPGP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058865">
        <property type="entry name" value="GDPGP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058866">
        <property type="entry name" value="GDPGP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20884">
        <property type="entry name" value="GDP-D-GLUCOSE PHOSPHORYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20884:SF8">
        <property type="entry name" value="GDP-D-GLUCOSE PHOSPHORYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26216">
        <property type="entry name" value="GDPGP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26217">
        <property type="entry name" value="GDPGP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GDPGP1-like N-terminal" evidence="14">
        <location>
            <begin position="50"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="GDPGP1-like C-terminal" evidence="13">
        <location>
            <begin position="219"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF26216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF26217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8193358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="375" mass="43021" checksum="FFD9F948D98ED49D" modified="2024-11-27" version="1">MNTVGGAYHVKPPMISKSGSFIHTMALTISYDNEEFFFITRRDSGEKSLIDEQLQTIWSDKVATGCFKYELGDLSTKQLFGKYGFVVQLNENRATKRRKPQLVFDVAMEFNPHEFHFGKVPEKEVIFIIQPQHWLEREKNSHVLLINVSPLEYCHSLLVPSIEKCLPQILKADEFRLAVELMLKSKDSFFRIGFNSLGAFASVNHLHFHAYYLKYELFIENAPTKHLVDSISNPCAVYELLDFPAEGFVFEILEDIHVFDVTRSVVKLTDCLLANNIAHNVFLTRGRPLSKPTTDYSELNALRIYVWAREAHYGVKDGNSFNVAVCELAGHIPMKDQESFKNITEEAIASELYKACHETFTAVRPIIKNMFHENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCW6</accession>
    <name>A0AAV6VCW6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCW6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="9054" checksum="A81DAFCDE4FE3D29" modified="2024-11-27" version="1">MPNACARNCIWVRMNGGHWTKGSFQVTWRAQSRAVLVDVFSGVELQFGCLDFASTEGATEGEFEGRLWPSRNSRFVIVVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VD88</accession>
    <name>A0AAV6VD88_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000114">
        <property type="protein sequence ID" value="KAG8193850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VD88"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="112" mass="12148" checksum="BB980D12C01FD68B" modified="2024-11-27" version="1">MQSHPYFSWTRWSTETVHPIVTKPSNVSSPNHITTKPLSPKPYLHLPNPLGGPFGAIPSPPNREDQADPSSPASVLSPASAEAPQKQSPTKGGMLRRSGIPRKRPRLRPGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDL8</accession>
    <name>A0AAV6VDL8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">c-Myc-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_005041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AMY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000115">
        <property type="protein sequence ID" value="KAG8193743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDL8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026060">
        <property type="entry name" value="AMY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168">
        <property type="entry name" value="ASSOCIATE OF C-MYC AMY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168:SF0">
        <property type="entry name" value="C-MYC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02028">
        <property type="entry name" value="CMYCBINDINGP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8193743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12722" checksum="DAD4A117CD084EAD" modified="2024-11-27" version="1">MSVSPDVHSFCLNKNHVSPTVDSVREEFRKYIENEAVLNVLTRVLKDLYEKETKPTDPLNFVITKIGALSFDGREIASLKDEIRDLRALIKDLQEENGYLKEKLEQQTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDQ0</accession>
    <name>A0AAV6VDQ0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nuclear envelope integral membrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_028387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000110">
        <property type="protein sequence ID" value="KAG8194045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDQ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019358">
        <property type="entry name" value="NEMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13598">
        <property type="entry name" value="AT07567P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13598:SF1">
        <property type="entry name" value="AT07567P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10225">
        <property type="entry name" value="NEMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043978200" description="Nuclear envelope integral membrane protein 1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8194045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="47833" checksum="4949803CD5681480" modified="2024-11-27" version="1">MSFFKKANQICLLLFIFFSTFSHVVLFSEQSTSGASNVVQLKPNEILPKQDNINFKIFCYNSIPKSILYLWRTVHLVFEKVPLSYEIFPGVNETEVEDKHAENSVWFKPSWFSGQQTYVDFPAFSNYCLGISTEENYAIQLQVRTINYWRLLQFIIGLLLFVSAPSLSRNPFFHYTSAISLGVLGSVLVILYVISRFIPKKTTSYALLFFGYSFILYIFQSIWKDISEIINRNLDIVVAYCLCAALISFVICYRFGPVENVRTFNIIQWSMQTLAAILIYLSSEYREVSTAIILIVIGLRQIPGKWIKAIQMLWYRYFPPKRALLSKEEYIHQGEVETKKALDELRKYCSSPECNAWKTISQLRDPIKFAGFIESGHHVSFEDSFAHAAVGYDCETDDESDAEESSFRGNGVLQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VE00</accession>
    <name>A0AAV6VE00_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_011501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000113">
        <property type="protein sequence ID" value="KAG8193951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VE00"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052278">
        <property type="entry name" value="Chordin-like_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46526">
        <property type="entry name" value="CHORDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46526:SF1">
        <property type="entry name" value="CHORDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043933260" description="Secreted protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20606" checksum="7D44D0F1DCCB143C" modified="2024-11-27" version="1">MCRALLVALAVCATLVQISSAASERKKIRPPLVEEAGRRKLQKQTHCQFGNHSYELEERWRPDLGPPFGMLFCMRCECIPATVFLSSFTKKSGSTFRMRPSDKMSPPKLGTLIGGRRAHVLTCQIHGTYDPFLPTTAIQELMSPLAFRARCCQPPKNHKNRPVSDFWNVRTPTKDAHPPSGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFW0</accession>
    <name>A0AAV6VFW0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000096">
        <property type="protein sequence ID" value="KAG8194946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFW0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="21590" checksum="8E9021E3351A6423" modified="2024-11-27" version="1">MLRSLSTVRKAINSSKNFRTPFTASRVITRNSSVTTWNKDWKPGPYPRTEEERLAAAKKYNLIPEDYEPYPEDEGMGDYPMFKKFHNESRDQFEPYDYWCLKRNFGEPVHTDVDIFQEDKINFQLKMPFPLWQQFIYLMGGLSIFWGILYYDLTHPYNQRKVPKQFPLDGMTYYTFEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VG13</accession>
    <name>A0AAV6VG13_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_021410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000096">
        <property type="protein sequence ID" value="KAG8194949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VG13"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000001">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000008">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000007">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF4">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="89"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8194949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="406" mass="47054" checksum="900F4A26868FBC03" modified="2024-11-27" version="1">MASSSNVSVDESFANTTNGSIVPEQNGYDNSEGAVDRFGFIGSKTPNLSSALPVEILRHRELKWLEMLENWDLFMTKKYKKVRERCRKGIPPALRARSWQYLCGAKFYMDNYRHKFTELDGAAGDPRCVDDIKKDLHRQFPSHEIFVHSQGHGQADLFRILKAYSLFNPTVGYCQAQAPIAAALLMHMPAEQAFWCLVAICEKYLPGYYSPGLEAIQVDGDILFGLLKKASPTIYKHLKKQRVEPILYMTEWFMCAFSRTLPWSTVLSLGMFLRKSKGRTYSYMTEWFMCAFSRTLPWSTVLRVWDMFLCEGVKVLFKVAIVILKSVFAKTETLKNCPSMYETLETIRHIPEEYLQEDYLVQQILKLNINEHDMEKEHQRQVAKRRTIREQQTMQEQVNGKSKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGC6</accession>
    <name>A0AAV6VGC6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_029614</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JAFNEN010000094">
        <property type="protein sequence ID" value="KAG8195032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGC6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF12">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8195032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="256" mass="30685" checksum="DD9EA6F5DC4086E1" modified="2024-11-27" version="1">MSVFEDISNFLYAEDYHDRALIKHPSIIITTVFVYLLLVKWIIPHLMRNRKPFSLKWAMIIYDFGQTFVNAYLTYNLFTFSFSLWDERCMMKTNPNLPVYQKRINVIAWRIYLVKIADLIDTIMFALRKKDDQVSFLHVFHHCLMCVLVMFFLRSLDKTSMGYFLGVGLSINTTVHVFVYFYYGLAAFGPHMNKYLWWKKYLTQFQIVQFFVVLSYIGYGWATGCEEVGRMEVSLFVYVLTILFLFFNFYKKYEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGF6</accession>
    <name>A0AAV6VGF6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptor Mth2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_023335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000092">
        <property type="protein sequence ID" value="KAG8195158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGF6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043899542" description="G-protein coupled receptor Mth2" evidence="7">
        <location>
            <begin position="19"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="644"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="718"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="9">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="8">
        <location>
            <begin position="486"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8195158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="91270" checksum="1308083B5AA6CFAD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGU2</accession>
    <name>A0AAV6VGU2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Obscurin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_023344</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">A band</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000092">
        <property type="protein sequence ID" value="KAG8195170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000345">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000873">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000033">
        <property type="entry name" value="Muscle M-line assembly protein unc-89-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="palladin isoform X1"/>
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        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
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    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF3">
        <property type="entry name" value="STRIATED MUSCLE PREFERENTIALLY EXPRESSED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="948"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="14">
        <location>
            <begin position="1040"/>
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        </location>
    </feature>
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        <location>
            <begin position="1229"/>
            <end position="1338"/>
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        <location>
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        <location>
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    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="2002"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="2078"/>
            <end position="2167"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="2172"/>
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        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="2265"/>
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        </location>
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    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="2360"/>
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    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="2556"/>
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    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="2651"/>
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        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="2744"/>
            <end position="2859"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="2871"/>
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        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="2966"/>
            <end position="3057"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="3066"/>
            <end position="3155"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="3186"/>
            <end position="3280"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
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        </location>
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    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="3401"/>
            <end position="3490"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
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        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
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            <begin position="4238"/>
            <end position="4488"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
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            <end position="451"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
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    <feature type="region of interest" description="Disordered" evidence="11">
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    <feature type="region of interest" description="Disordered" evidence="11">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1429"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1447"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1458"/>
            <end position="1472"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1473"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1484"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1511"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1560"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1570"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1628"/>
            <end position="1716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8195170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4545" mass="509004" checksum="EA8E2C94CD1FADAC" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VH93</accession>
    <name>A0AAV6VH93_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_001142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000076">
        <property type="protein sequence ID" value="KAG8195907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VH93"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000413">
        <property type="entry name" value="Karmoisin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF312">
        <property type="entry name" value="KARMOISIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="47"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8195907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="519" mass="56380" checksum="C5CF76D9FD3F80D8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHA2</accession>
    <name>A0AAV6VHA2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000095">
        <property type="protein sequence ID" value="KAG8195026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHA2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9583" checksum="E89F4C0ECDC8B244" modified="2024-11-27" version="1">MCNKPFAIAPALHPSVISAKESVPVSCEVPVTCSKPPTSEEWTLVTSKRHPRLAIKSNSKLHVVCQFDSHVLLVGLSRAKYVFLKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VI38</accession>
    <name>A0AAV6VI38_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase PPP1R11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein phosphatase 1 regulatory subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_001379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000089">
        <property type="protein sequence ID" value="KAG8195361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VI38"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8195361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="119" mass="13506" checksum="2B135A2480017BFB" modified="2024-11-27" version="1">MAERQPLKSNEGESSTIVVDTEETEPGQEPASARMMLKKPKSKKKVAWSSDTVDNEHMDKKKSKCCCIYEKPKAFGESSSESEDECEHCKGHTDHKRKQPKENPSQDENHSQPIENKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKQ5</accession>
    <name>A0AAV6VKQ5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_007501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
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    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
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        <property type="entry name" value="Fibrinogen-like_C"/>
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    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
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    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
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        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="F5_F8_type_C"/>
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    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
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    </dbReference>
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    <dbReference type="SUPFAM" id="SSF56496">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
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    </dbReference>
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        <property type="entry name" value="C_TYPE_LECTIN_2"/>
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    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043731173" evidence="6">
        <location>
            <begin position="20"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="361"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="8">
        <location>
            <begin position="935"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="1226"/>
            <end position="1342"/>
        </location>
    </feature>
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        <location>
            <begin position="1368"/>
            <end position="1494"/>
        </location>
    </feature>
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        <location>
            <begin position="1570"/>
            <end position="1588"/>
        </location>
    </feature>
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        <location>
            <begin position="1582"/>
            <end position="1597"/>
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        <location>
            <begin position="1602"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1609"/>
            <end position="1627"/>
        </location>
    </feature>
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        <location>
            <begin position="1621"/>
            <end position="1636"/>
        </location>
    </feature>
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        <location>
            <begin position="1641"/>
            <end position="1653"/>
        </location>
    </feature>
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        <location>
            <begin position="1648"/>
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        </location>
    </feature>
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        <location>
            <begin position="1660"/>
            <end position="1675"/>
        </location>
    </feature>
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        <location>
            <begin position="1687"/>
            <end position="1705"/>
        </location>
    </feature>
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        <location>
            <begin position="1996"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="2003"/>
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        </location>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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        </source>
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            <dbReference type="PROSITE" id="PS01180"/>
        </source>
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            <dbReference type="PROSITE" id="PS50022"/>
        </source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAG8197249.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2032" mass="230510" checksum="FF0A61CA1CACF633" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKT1</accession>
    <name>A0AAV6VKT1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">INO80 complex subunit E N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_014515</name>
    </gene>
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        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000064">
        <property type="protein sequence ID" value="KAG8196783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000827092">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TBRG1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA REGULATOR 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <end position="106"/>
        </location>
    </feature>
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            <end position="43"/>
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            <end position="176"/>
        </location>
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        </location>
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        <location>
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            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24237"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8196783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="381" mass="41932" checksum="2FB6A9683A98AAAC" modified="2024-11-27" version="1">MDRDIFNEFLSDDGSPHLGRNVVVHSSNEPESSSSPFFNPSQSSSSIIEKRAERISNDIYREKYRKLKRYVKDFVFENAAICDEVARVQEKILIAKEERRFLLKKLQAFQILKDGSTQVPTAPSTSAVPTSSKNTAAEAQEPSVKKKPSGKKRPAPKTTEEGAPKPKPKRRKVPTDKRLVTQIPLDAAGRPIFPIVLGPLTIHSLGVIISDRPGFHTEQCIFPAGFCSSRTYASLKNPVSQCLYQCTVTDSSFGPRFEITPEDDPGHSFVGSNPNEVHIALLKALNAACGKEVVSIDGQGAKFFGLSHPTIQNLIQSCAGARKCLDYRWVQFEVAKLAEGEEDTITKDFDPTVNFDVLIHVIKESTQVVSTSSGLVVKKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLL7</accession>
    <name>A0AAV6VLL7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_014180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000067">
        <property type="protein sequence ID" value="KAG8196623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLL7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000004">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="758"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8196623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="888" mass="99188" checksum="24AD85DB6ED08570" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM27</accession>
    <name>A0AAV6VM27_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_020124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000049">
        <property type="protein sequence ID" value="KAG8197847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM27"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006670">
        <property type="term" value="P:sphingosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="157"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8197847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="443" mass="50227" checksum="CD75DF6D26A2F8A5" modified="2024-11-27" version="1">MMSESLSFGSRISSLITHLRDPYLVSGFQNFFGVYLVDSVSNGNVNSLKNDKEANDKTKTKRSNIITIKYDRFDGDNFLRHRKTPSSGSENSKNSPFTSDGEEISDVDTDLEYTAQCKIENKFWYYFFSFGAGLGYEMFYASFFPFWIWNIDGAVCRRVINVWVLIMYVGQAMKDIVCWSRPAAPPVIHLEPQYVVEYGMPSTHAMVGAAVPFSFLYFTLHRYEYDVIYGILIAIGWCILVCCSRLYMGMHTVLDIIAGLVLVTILMSIILPFSDLIDNFQLTNPYSPLITIAFMLVLQLIYPNADRWTPARGDSAVIMGTGTGFALGSCLNYYQGFIRGPALPPPYMIMWPGYKVFGLALLRAMIGISCIVATRAVFKNFTHALLCFIMRVDSRDLKSKQKILVEIPSKFIMYTAIGFVITYVSPFVFRLLCIERETAFTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VN56</accession>
    <name>A0AAV6VN56_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CIP2A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_021316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000053">
        <property type="protein sequence ID" value="KAG8197586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VN56"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042510">
        <property type="entry name" value="CIP2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048701">
        <property type="entry name" value="CIP2A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23161">
        <property type="entry name" value="PROTEIN CIP2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23161:SF2">
        <property type="entry name" value="PROTEIN CIP2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21044">
        <property type="entry name" value="CIP2A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CIP2A N-terminal" evidence="3">
        <location>
            <begin position="22"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="664"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8197586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="968" mass="110041" checksum="DCAE4F19EB9144DB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNM5</accession>
    <name>A0AAV6VNM5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_021566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNM5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF70">
        <property type="entry name" value="NK7.1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="263"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="265"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8198315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="514" mass="55906" checksum="1CBEDC8AD1787FBE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP69</accession>
    <name>A0AAV6VP69_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phosphoglucomutase-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_013448</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000056">
        <property type="protein sequence ID" value="KAG8197321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP69"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000035">
        <property type="entry name" value="Pgm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="52"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="221"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="337"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8197321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="68291" checksum="2D7E22CDD372BEC5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQS5</accession>
    <name>A0AAV6VQS5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_001814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000033">
        <property type="protein sequence ID" value="KAG8199019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQS5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8199019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="19373" checksum="90E8C4428BC2CC8F" modified="2024-11-27" version="1">MPKVKSGSKVIHPNSRKASQLSREEHRGLKLDRRKRESDLRMRAKLRKLRWFRDNVDQSKGVYTSEEVHELIEKYLQRFSEEDKKLEEQRSIKGRRFQERLGHEYKTKFAIEREKTLYETPHVGIEVPNLTTKAAFEFLIKWNGESNFVPAIDMVTVSKLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRW3</accession>
    <name>A0AAV6VRW3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRW3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="82" mass="9240" checksum="B1FC161E042C5E7D" modified="2024-11-27" version="1">MISTNQLLSRLYTSLYDLGYSNLGVPVGFLVWLFRLLNSQLAVQQFLAFGPFQAKIFALPVTGWCYLSNTSTKKKSTPVVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS62</accession>
    <name>A0AAV6VS62_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_021562</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VS62"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF12">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043820836" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="10">
        <location>
            <begin position="16"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8198311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="256" mass="29445" checksum="AB96542C5F6EF99A" modified="2024-11-27" version="1">MFGLFLCKFVPFVQGSTVFLSAATVSAIAIDRQKNVLNLLPTKRRIQNKEVIGIITAVWTISLVLSSPVPYAQTIKKVGLPHFYTYEKCVEKWPWSTAKGAYTVVILIMQFLIPALVLVTTHLKIESHLNVAKKRSNNSSRPSVDRVEIERHRHRRATYILMIASAVFGITWLPWNIFSLIADFYPECMSAENLYLGFVICHIIAMTSTTTNPILYGWLNSNIRKEILVVRDELRRVISIKKRRERAHRRNTIEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VW27</accession>
    <name>A0AAV6VW27_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000011">
        <property type="protein sequence ID" value="KAG8200895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VW27"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="143" mass="16776" checksum="5C2F94287EF44990" modified="2024-11-27" version="1">MEVSAYASDRRNCCTFSRTLRRPGGVGRLEFLWLRAYGLEELIAEILNENSQARHLSNERLYDGWLGRYMVLLKAKNPRQRTDVQESIKFIDSFLRSSDQFQLLPSPFFIHHYEQSVLSQSFPLVEDFDLSKNGTIQTEWHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWD2</accession>
    <name>A0AAV6VWD2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000012">
        <property type="protein sequence ID" value="KAG8200872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWD2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="216" mass="23776" checksum="4FDAD9F22262F5B5" modified="2024-11-27" version="1">MLRQRLVRQGAMNISSGSDSTMSSPTPVRKRRSSQDSKMYTQVSSESMDSLIGGLPASKSVDGKPRYGRRHSMAASVLYVDIQKPSLKSALNSALKKVSSACSVLSSAQSSTFNLNPPKNKDQVEEDVIILPHVLATFQKAYMPPIPPNCTLQTTKFQVNRRFSTDCPPPSYMEAWNIPSVGTRQKLARQQEVVVSSRGSSTDDEAVVHMEDRLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWZ7</accession>
    <name>A0AAV6VWZ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">JTE90_000656</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWZ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000055">
        <property type="entry name" value="Polycystic kidney disease 2-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000020">
        <property type="entry name" value="polycystin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF183">
        <property type="entry name" value="AT14535P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 19" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="19" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="18" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12 19" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="622"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="637"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="646"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG8200586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="806" mass="93068" checksum="6AEFF265AC1B7B4E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXB9</accession>
    <name>A0AAV6VXB9_9ARAC</name>
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        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">JTE90_028576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000016">
        <property type="protein sequence ID" value="KAG8200401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007624">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ENOX"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001:SF4">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER 1-LIKE PROTEIN"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <location>
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            <end position="238"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8200401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="591" mass="67472" checksum="5B1F464296F88360" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TD90</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006544">
        <property type="protein sequence ID" value="KAG8155842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TD90"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="324" mass="36262" checksum="7158B47A81F4A935" modified="2024-11-27" version="1">MMYRPSQTTHLKSVLGADRARTRRPARLGLERGILTGTLSRLTDHPYPRSLRIELADFPYHIVSIVTKRLFTLGTFLRYGVLTRQRKINTISPRIFQGPQRRQPDTARDACFYENQRPPIFRTSRFQGQRNLTKKRYSSPGPPSTSPPSSVRYRLGPKDLSPCPVGNLNPIPFPVGRGDNTSMCLAFRQRLASERNFSDPLGPTDPCSTAVPWNPSPLQSPQLSLEYLLLPPRSAPVAAPGGSRPGILQSTHGHRDPPTHCMRRNLHDGSSAVAARYRAHAGASSIFRSKFCFVGELLQHSLANFRLPWHRPLSRATTTFHGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEU3</accession>
    <name>A0AAV6TEU3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulator of rDNA transcription protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005947">
        <property type="protein sequence ID" value="KAG8158041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEU3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8158041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14070" checksum="F126A9989F980543" modified="2024-11-27" version="1" fragment="single">MIGRADIEGSKSNVAMNAWLPRASYPCGNSSDTSCIKLVKSKGSIGPAFAVRIHTENQDQASFCPFALREVSVLAELALGHLRYHLTDVPPQPNNPPESVLGADRALQGGSALGARSVILTGRFPLNRVSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGK7</accession>
    <name>A0AAV6TGK7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fructose-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_028191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004625">
        <property type="protein sequence ID" value="KAG8170970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGK7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01516">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00330">
        <property type="entry name" value="glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447:SF0">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE 1 CLASS 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8170970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="58714" checksum="5B9111373791CC00" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIM3</accession>
    <name>A0AAV6TIM3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003584">
        <property type="protein sequence ID" value="KAG8171765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIM3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="8400" checksum="595CFD96BDD491EA" modified="2024-11-27" version="1">MASPTHFGQQPRSRDLLQSPSPARSLLNATFPHALASGGFGAGLLPVHIAVTKGIPVGFFSSAYLLLKFSGFISSDLRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJ44</accession>
    <name>A0AAV6TJ44_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003377">
        <property type="protein sequence ID" value="KAG8171927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJ44"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="350" mass="40447" checksum="D40787F2D841F2D7" modified="2024-11-27" version="1">MSVVERIYVCPRTVSKDDLSAEKEAIVSDFNNLVFENIPCSDSSNINYNDGKEADPFDKIATYYGRQKNVFLFISLLRNCEFSALILNKIKGKCSTEQFESFIERTTLYLTRIKQGEITAREFLNGDHFPGAFFNGYHCGEKKNFHENLNVNFTQSTQFLDVQDIFIRKIDCRESGELLRVKIFENGLRAVTVEKDQDARKYSFSKNAACQLVLKNDKSSLYLDIIAGKVANVEREVGDVRATLTKVSEVSDELLNYSEILINLQSLKEVLLAYFDEKRMLDERDWFVQEQCLPIKTFEDLENWKPAEHQHVTERLLKRKKAEGPKTLVCHDMRGGYLDDRYGFISLNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJ76</accession>
    <name>A0AAV6TJ76_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003336">
        <property type="protein sequence ID" value="KAG8171957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJ76"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="40"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="211" mass="23629" checksum="8ED4C44A49CFAF79" modified="2024-11-27" version="1">MDDTSTSGGEGEEDNDFCFLPCPKNPSLDVEDFRRRLVLAHNGYRKLHGAPNLSHLQELEDAAQMWADTIAARGIKLYCEKLYNTGENLCSIDIINSVPSAEGIVHNWYKEIKNYSFANPDGDAAPFTSARCYGALAPTSASVLPLCPDSPDYLWWCDTTQGAIPTCPESSRETSCRGCPREVRRLWTTPRRSSGLIQDRGVWFLRMPTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJB0</accession>
    <name>A0AAV6TJB0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003429">
        <property type="protein sequence ID" value="KAG8171887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJB0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="154" mass="17403" checksum="5B6B238CF01B9F3C" modified="2024-11-27" version="1">MSVVDYVATCSFMWINKKCLPSKIAFVSVHEPSVVFTVEPDPSTCYFSMQDVLLNMSLPANPFDVKKEPGEAFVVPVWDMERYISRDFHTKYLERQDIWEKGIVGCLDIATYNYLFPLLPLGTVKYLGITNVSPTLEAQHAAQVLSNNNSGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJS2</accession>
    <name>A0AAV6TJS2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003355">
        <property type="protein sequence ID" value="KAG8171943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJS2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="49" mass="5241" checksum="98CA1C35A5194611" modified="2024-11-27" version="1" fragment="single">MEPSPASVLRLSLEYLLLPPRFLTGAAPGGRTPGHLQRTPPRTLLPHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMZ3</accession>
    <name>A0AAV6TMZ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002125">
        <property type="protein sequence ID" value="KAG8173038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMZ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="134" mass="14849" checksum="D3F46B635DF02E92" modified="2024-11-27" version="1">MDGLPLFSSSSQAFWPILAKCSNVNQLSNLSFSPLEFILVWANPPVVPNFDMFVKEATHLFHNGIVLNGIKVKIVIEGFICDAPANAFIMGVKSHTGYSSCTKCTASGTWYHNRVTFHDLNAEDRFHVGEKSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNU3</accession>
    <name>A0AAV6TNU3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001713">
        <property type="protein sequence ID" value="KAG8173482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNU3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="134" mass="14602" checksum="3051721D53A293E1" modified="2024-11-27" version="1" fragment="single">MIQFSFRELALALRLQTDRELGQDPQRRPCSPPVACPCPPPAPPSLPSPPHEEREGGGRPREEQVRIPARSPGEGTRTERAGEASGGRTLPCGRPDVLDPPPPSDHQMAFMPDTVARRGGGWSRNREAVPQWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPW6</accession>
    <name>A0AAV6TPW6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001456">
        <property type="protein sequence ID" value="KAG8173872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPW6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043417324" evidence="1">
        <location>
            <begin position="19"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="187" mass="21452" checksum="08FAD53EBE1E8489" modified="2024-11-27" version="1">MNLLMALTLLKTVWFVSCEVNPFEEYEEAISECNEAFYCKINNPQLVMDVNLSGGPKFTKMIIEWTKEMAHYDVPYDGSVEYFGNYSKHFCALPREEKREINRKYFDVGCEFYMDNCANTKSEECVRFMNYLWENQAAGMKIIAQGHCLEVAKLLPLPEEMKQMAEVTSKAVNAAKNALASVTNIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQQ0</accession>
    <name>A0AAV6TQQ0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transferrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001249">
        <property type="protein sequence ID" value="KAG8174342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQQ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001156">
        <property type="entry name" value="Transferrin-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485">
        <property type="entry name" value="TRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485:SF29">
        <property type="entry name" value="TRANSFERRIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00405">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51408">
        <property type="entry name" value="TRANSFERRIN_LIKE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transferrin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="115" mass="12863" checksum="2E0F6591B5B4B207" modified="2024-11-27" version="1" fragment="single">MKKYYGLQPIASEFYQKPEDTYFAVAVLRRASDVKYVYQLRGLRSCHSGLDRPAGWYFFLSVPRGETCNRVGAMADFFEGGSCAPGANDPSINPGRVRRDDLCRLCAGDARGLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRV4</accession>
    <name>A0AAV6TRV4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_019713</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010001169">
        <property type="protein sequence ID" value="KAG8174649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRV4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Retropepsins" evidence="9">
        <location>
            <begin position="287"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="10">
        <location>
            <begin position="491"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="810"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="840"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="888"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8174649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="903" mass="102422" checksum="7B17F47532C8D1C1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRX6</accession>
    <name>A0AAV6TRX6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001262">
        <property type="protein sequence ID" value="KAG8174288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRX6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="176" mass="19626" checksum="DE398E293A0C31FC" modified="2024-11-27" version="1">MKELYNPIVSSLEEIKCWDDKDTSSGADVLLTAICQSEYIVSLVSAEKLLSYTLILCQKLQSSDADLWAALNYADYVLQSLKSLREKVDEFSVLFQEAQKMVELNGTTIKRLLGLIIGNNAKIALCNGAAMTQLETAGLEVSMPVQPGRPQRSWISMARRPWKNRALQEVGRILSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSP8</accession>
    <name>A0AAV6TSP8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_017615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001109">
        <property type="protein sequence ID" value="KAG8174937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSP8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="61"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8174937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="398" mass="44765" checksum="5D0CA805862576E4" modified="2024-11-27" version="1">MKVKHNTVHYIETTGPPIHSKPRRLNPKIYEEVKNEFQFMIDQGICRPSKSPWSTPLHIVSKASGDIRPVGDYRRLNSVTIPDRYPIPHIQDFSNALHGKCIFSKIDIVRAYFHIPIHPEHIPKTAANGLVEEFHRPLKAAIKAYNTDRWSDALPTILLGFRTTFKDTLQATTSELVYGTTIRLPGEFFEPTPSETPPNQLVEDLREHFANIRPAPTSSHGKPKVFIHPHLHRCTHVFLRTDKVCKPLQPPYEGPFKVLLRREKTFRIAIGRREVEVSLDRLKPAYYCAADEPPPTTSSNTPTGASPTANDPTTPSDNGPDLRTPTAPSNIEQETPPGDATAPEPSQVPRTTVPRRSSRPRPQTETKTTRGAADDTIPKPILKTSSGRTIRQPLRFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTI0</accession>
    <name>A0AAV6TTI0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_021290</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001157">
        <property type="protein sequence ID" value="KAG8174740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTI0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8174740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="180" mass="20579" checksum="217DEF853223D13E" modified="2024-11-27" version="1">MQSNQEVCIQMCVQERNYDSCGCVDPTFLIPATLNFSLCDLRNETDICCLDRVDSGSCDCPLPCVSTYYNEMVSTSTLMKSRYNNTLLDEYSNNTRTDEINLYDRVDLKMYYSTLESSVYQQKKMFEESELFSHLGGELGLWLGLSLVALFEMMDDAMYLLKFVISTACKTSKKDCDNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TU36</accession>
    <name>A0AAV6TU36_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000996">
        <property type="protein sequence ID" value="KAG8175477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TU36"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="114" mass="13352" checksum="D876940EC5AD4878" modified="2024-11-27" version="1">MGPSPFKFNQICLSRIATENTPSSLFLFFSRLFPVAEACEFHLSTLQMKEDYNEMEMANNRLNPINNTVYHWHNKWRLLNLGPRSAIGLIEKLKEGKNRHICEEKGITHLLWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUB9</accession>
    <name>A0AAV6TUB9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001048">
        <property type="protein sequence ID" value="KAG8175213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUB9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="204" mass="23256" checksum="C6F09D64F330BF45" modified="2024-11-27" version="1">MAVWKKWVLKPAKTSRSFRRFAQTAKSVTHLKAIVKKNKALEFAIKRIFNKTTAKVALGATVVGVGISYINDYIQSNSGCFIKSNNSVCKVKELSCCQPEQVQDVPFCKMSSSLLKPDTCKGFNEDAEKSCCRYCDCKFNDCLPNQTMECRRPTISEALSHYAQAWTTSFWQAITDMFPWLIWIFSILAVLFAVWFGRKMVKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUM5</accession>
    <name>A0AAV6TUM5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001026">
        <property type="protein sequence ID" value="KAG8175348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUM5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043697775" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12132" checksum="E210BDB229C92791" modified="2024-11-27" version="1">MNSLTIPLLFVLLCSAVFSEASCSPGDVKPRERRGIAGGYNRTTHYVTQGNLGSAIGRFSYNTLCFSVSWVPFKGCTYPPKTGGGTDPGTGTTDPSVTCGPKPDPADDMCCLCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVS7</accession>
    <name>A0AAV6TVS7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_002361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000955">
        <property type="protein sequence ID" value="KAG8175728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVS7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="115"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="248"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8175728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="364" mass="41474" checksum="43F27206D2037FD9" modified="2024-11-27" version="1">MASEGKQLPPTQRSCCKLVLRLLFSHVGLFLLVCLYAAFGSWIFVSIEYDYETYRRKERMIRSIDVNDSIAYLSALFYYLRDKASAEEWNKRVYTELKSLDRFIVGVAKNFSYDSTMDEEEWDREWTFGNGLLYTVTILTTIGYGHVTPHTQLGKIVTILYSLIGIPLTFIFLANIGDVMASGVRYAYSRLCCRWCRGQRRRNEYNREMVAQMGGRLPALSTDDVGNESFMPTSKIQIPILLNLVLISLFILLGAGIFANLEDWDMLSSGYFTFVTLTTIGFGDYYPGSAFQGYKGDITKTLSLMGTCFYMMLGMALVSMCINLMQEQLTSKVRWVAHEVGLIQLPDIEDTDDKPLTNLSEEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TX39</accession>
    <name>A0AAV6TX39_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000864">
        <property type="protein sequence ID" value="KAG8176587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TX39"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="192" mass="21438" checksum="B10AB3F0C258A1AD" modified="2024-11-27" version="1">MKIVPVIQEVFSKINVDACGPLPVTPSGKRYLLTAMCLSSKYPDAVPVEDITSVTVVDALLQIFSRMGFPKVLQLDQGSSFTSALSTTFLEKFGIKVVHSSVYHPQSNPIERFHRTVKRVLKVLCLESGSDWEQAIYPAMFALRTVTHESTGFTPADLVHGKNLRTPLTLLYEKWLDVEETEGEPVTEYVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TX58</accession>
    <name>A0AAV6TX58_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_024238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000864">
        <property type="protein sequence ID" value="KAG8176575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TX58"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="10116" checksum="049AA32B0417FC90" modified="2024-11-27" version="1">MSATRTKVITLYKNLLFLGKDYPKGYDYFKTRLKESFLKNKEVKDKAQIEMLLTRGQYIIKELEALYMLKKYRTLKKRYYSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYC5</accession>
    <name>A0AAV6TYC5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_003382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000849">
        <property type="protein sequence ID" value="KAG8176751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYC5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51457">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEN" evidence="2">
        <location>
            <begin position="61"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="250" mass="28297" checksum="5F41384755E62C20" modified="2024-11-27" version="1">MNIAMAYQKYLEVLKKEAIAKEEKLAHLKEKAKKYKQKYRAAKEEVQTASYREPESLKEIGPNVRVPEAKLALCRGTDSLKYTGDLMEVVFGSDVLASHVLKGIRGRSKTSVLDPLKVRDIEAHVVLKFGVDRRNVRYAMRIKLNYMHKLYKRRAAYNERTGLTIWKTVSVPGSSADIPGFSAEIPEEDGDVGAADGPSMVEPSFLDPTKKKKRTAVQFLMDQHEAKVARTEARQEARMNRPLSSLLEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYG9</accession>
    <name>A0AAV6TYG9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Solute carrier family 35 member B1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_012847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000842">
        <property type="protein sequence ID" value="KAG8176903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYG9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8176903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39478" checksum="94C024C00AFE79F5" modified="2024-11-27" version="1">MKTEPVVIAVDDFSRAGANKLFDDTALYLNSAASEGRMASNKKLFICAVGILVCFFYFGILQEKITRSTYGKSDKFTFTSMLVFVQCLINTIFAKIMLHTLMKQGQDSTRHLYYFCCGFSYLGAMVASNMALQHVNYPTQVVGKACKPIPVMILGVLIGHKRYPLSKYMFVLMIVVGVCLFMYKERPAAAVATKETLLGMGEILLLISLMLDGFTGAIQDRMRAEHQSKSGHMMYNTNLYSTLILAIVVLVSGEIWGFLVFMEKYPYILYDMFLFSIMSALGQVFIYLVVSDFGPLMCSIITTLRKFFNVLGSVLFFGNVLLPRQWAGTALVFTGLVLDGVYEKKGKKKAADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYW1</accession>
    <name>A0AAV6TYW1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000822">
        <property type="protein sequence ID" value="KAG8177068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYW1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25889" checksum="7526756D979C3539" modified="2024-11-27" version="1">MVEQMHRPLKAAIKAYNTPRWTSALPTILLGFRTALREDLQASTSELVYGRTLRLPGEFFEASPREANAKQMVEDLNDHFNEIRPVPTKPHGRRSTFVHPSMKDCTHIFLRRDAVKGPLQSVYEGPYKILKRTEKTLELEVKKDNRTVSLDRVKPAFLAQRDDTIQESMMPGVPAKPTIPESATPGVPAKTSTRPTLQTEEQSSSVPATRATRWVAEYTSPSILRCTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZK2</accession>
    <name>A0AAV6TZK2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000776">
        <property type="protein sequence ID" value="KAG8177510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZK2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="114" mass="12806" checksum="6BB6D55E36221143" modified="2024-11-27" version="1">MPNPQSSAKVLRHPWYKKACPHIPDGARRYRPSCRIPRTEKEREGPGVCVGPLFIRKEGHNQHGASSGCGDSWQRGPFFPLTILARVFTLGCALSWRLISLDGSHRFCFGIFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1F9</accession>
    <name>A0AAV6U1F9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000748">
        <property type="protein sequence ID" value="KAG8177814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1F9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="96" mass="11297" checksum="0E2564C7A5465750" modified="2024-11-27" version="1">MPRSSGKVFKKRKGKFYPKKNVPVPNTGEKKCARENKLSNLDESYAEFQEDHDTYDWIAAARTYGPSEKLNEFESLREEGIRLTAQFEYNQRIELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2F8</accession>
    <name>A0AAV6U2F8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_008340</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000758">
        <property type="protein sequence ID" value="KAG8177716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2F8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048878">
        <property type="term" value="P:chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000009">
        <property type="entry name" value="aquaporin-4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8177716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="30623" checksum="CFE96CC545DD8D37" modified="2024-11-27" version="1">MSDIPIIDRSRRKMSFKQKLRNMLGHEEFKKANIYKALLAEFLGTGMLVLVGCGSTTLWDKKSAPSVVQIALAFGIIMATVVQSICHISGGHINPAISLGCLVAGHCSILRAVLYLIVQCLGAVAGAAILWSITPGDLDSKLGMTALGKNMNGLRALGVEIIITFILVVTVLSVIDHKRKDVNGSAPLAIGLSITACHLWAFKFTGASMNTARTFGPAVIMNNWEHHWVYWLGPLAGGFIAGLLYKWVFEAPKAEEDKLPPDPLREDSEEGSSEPPKRPPPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2K0</accession>
    <name>A0AAV6U2K0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ycf1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000712">
        <property type="protein sequence ID" value="KAG8178193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2K0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="13590" checksum="85E57A9E54610C3C" modified="2024-11-27" version="1">MICNKNRKYRNKNNAEEERKRNLAFLRKTTEKHHFEMWQTEKNYFEQWEKRSSRNNFPLFFSHKGIFKNREKSNFSKRYSEAPSLCFWDLNCITSRLASLPELPKHSRNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2Y4</accession>
    <name>A0AAV6U2Y4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_011846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000733">
        <property type="protein sequence ID" value="KAG8177954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2Y4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8177954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="188" mass="21162" checksum="10491789CAA55638" modified="2024-11-27" version="1">MGYRLLDPTTNRVVVSRNVKFNEKKKPKDTVISDASHNNTEGTVADTPHDDNFEDGAPLSDNNLEDADQHSDDNLEDGSSSEDDNVDVGSPPDTDDSRRPRRDVKLPAKLHDYHLYQAFTVNLVPESFEDFEKLSSKEQVPWGKAMNQEMESLKKNKVWELVDLPNVEMHCHASGCCVSKETTSTKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5X6</accession>
    <name>A0AAV6U5X6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000651">
        <property type="protein sequence ID" value="KAG8179064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5X6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="195" mass="22403" checksum="0E8549D19901FCBD" modified="2024-11-27" version="1">MYPTDRHRDAAIAMEPRAAGLLNEACSILHWVPQPENVVDGNMNYGIAIQELLIAMFGSSEQEDVRDFNKVAFWQIEAVLADQHLDPCLAYHPDKCFTHAIYLEVSVPLVYELIIEKWHMFMPPMVGFCMLGELLMKSVYSFPFPPLYYEAPVTCDGGCGQKVFLQRRTHRRFVYHMTGCYSHPDDEYTSPDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7H0</accession>
    <name>A0AAV6U7H0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_006268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000597">
        <property type="protein sequence ID" value="KAG8179905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7H0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="70"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8179905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="354" mass="37400" checksum="130C6FE169F718D6" modified="2024-11-27" version="1">MSAACSEAICWKLMGVGVSISFLSSCCQIRGIGLLMFWSLVTSPPLPQRALADATGADQITKLLLLSVCVLVAQSISNAGITHAAVWAACCSYITQATPANLRSSAQGVLQGLHHGLGRGCGAVIGGIFVNYFGTQVTFRGYGFASLIVLILFVFVNYYKRDKGFASFQDDQEPDTVVEETAHLAPHGVPSNPMARSISKQNMGGPPQRMGGGNNNEGGGYGYGTANANSTGGYLGVPEGGGGYAGDVQNYTSDFNMNKTPVRPPVEAGGAITRRALAAAFNPKGILAQAASPEAAYEYEFIRRDFEAYDEVTSLAGNLNQNLSSKQDVLVGPKPKTQTYNLQPGNNTEVAYDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7Y8</accession>
    <name>A0AAV6U7Y8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_024214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000569">
        <property type="protein sequence ID" value="KAG8180299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7Y8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF5">
        <property type="entry name" value="VENT HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8180299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="768" mass="85445" checksum="71671839CFE37F67" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7Z8</accession>
    <name>A0AAV6U7Z8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000606">
        <property type="protein sequence ID" value="KAG8179709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7Z8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="132" mass="13903" checksum="4397783D24EC3179" modified="2024-11-27" version="1">MSAPSPDKAKDAGQKDGASAGQDPSCGGIQKAFDAYAKLSGSKDGKIKCDSVQQWIKKAGISGVSDDDVKKHFGKDGGLDLNEFKQGIEKLAKDKKQEKEDILKKLSSAMPSGGAATEKMDDIKSKLGGEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAR3</accession>
    <name>A0AAV6UAR3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_023747</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000550">
        <property type="protein sequence ID" value="KAG8180778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAR3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002466">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000534">
        <property type="entry name" value="zinc finger protein 674"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8180778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="359" mass="41570" checksum="1B8A611034013377" modified="2024-11-27" version="1">MEEVYNPDLTKTVTTSDTPVVVYVSTKRFICDRCHKGFKTNNALYHHILTHTNERPYKCHVCGKGFNNRGNLKTHSVIHTHEKPFVCPACGRGFNHKGNLQVHMRVHTQERPYACDRCGRRFTQKATLNTHILMHTQEARFECEVCGRRFRQKVNMKVHLQTHSKTKYECPECGHRVRQKASLKKHMELKHQRTGGPTVYLCWCGEKIKKIDDMRAHLESHVKEDVESSDDENSRGNDEESMDNEEVSIRIGEVSSMNNEDSRGNDEESMDNEEVSRIKEEESMDNEEISIRIGEDSMDNEEESRGNDNEESRGNEDVYSEEALEIVESEENEKPVDNEDSMEIVVNVEFLKAEEDDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBK6</accession>
    <name>A0AAV6UBK6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Talin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_023564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000517">
        <property type="protein sequence ID" value="KAG8181401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10569">
        <property type="entry name" value="FERM_C_Talin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17089">
        <property type="entry name" value="FERM_F0_TLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17090">
        <property type="entry name" value="FERM_F1_TLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12150">
        <property type="entry name" value="talin-RS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000005">
        <property type="entry name" value="Talin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000002">
        <property type="entry name" value="Talin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000003">
        <property type="entry name" value="Talin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000001">
        <property type="entry name" value="Talin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.10:FF:000001">
        <property type="entry name" value="Talin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.10:FF:000002">
        <property type="entry name" value="Talin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.10:FF:000006">
        <property type="entry name" value="Talin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000007">
        <property type="entry name" value="Talin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000028">
        <property type="entry name" value="Talin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032425">
        <property type="entry name" value="FERM_f0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037438">
        <property type="entry name" value="Talin1/2-RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057346">
        <property type="entry name" value="Talin1/2_VBS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015224">
        <property type="entry name" value="Talin_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036476">
        <property type="entry name" value="Talin_cent_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054082">
        <property type="entry name" value="Talin_IBS2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049108">
        <property type="entry name" value="Talin_R4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054060">
        <property type="entry name" value="TLN1-like_RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015009">
        <property type="entry name" value="Vinculin-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981:SF1">
        <property type="entry name" value="RHEA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981">
        <property type="entry name" value="TALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16511">
        <property type="entry name" value="FERM_f0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21896">
        <property type="entry name" value="Talin_IBS2B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09141">
        <property type="entry name" value="Talin_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21692">
        <property type="entry name" value="Talin_R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25177">
        <property type="entry name" value="Talin_VBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21865">
        <property type="entry name" value="TLN1-like_RS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08913">
        <property type="entry name" value="VBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109880">
        <property type="entry name" value="A middle domain of Talin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="6">
        <location>
            <begin position="90"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="7">
        <location>
            <begin position="2312"/>
            <end position="2551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2476"/>
            <end position="2546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8181401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2562" mass="274950" checksum="D3E0597CC2ECB278" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDP3</accession>
    <name>A0AAV6UDP3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000468">
        <property type="protein sequence ID" value="KAG8182329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDP3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="98" mass="11485" checksum="9291B52310AD29E8" modified="2024-11-27" version="1">MEGGDFFITVLDINILKVWSPYGRLLCITTHKNRILQSIRNVKGQIISLFTQQITRTNCGQEDPLTLISHPTFSRHFISRMDPFIHFYLLMDDRFLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEF7</accession>
    <name>A0AAV6UEF7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000461">
        <property type="protein sequence ID" value="KAG8182470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEF7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="171" mass="19093" checksum="1725F2C6533119EC" modified="2024-11-27" version="1">MIIHHGLEPVQSLLVPTRDVKTVRPQSCSLDLLLNLASCQEHVFFNCRSNEDRVSLRDISAVIFTGDPQGYASSGCLAVSPCFFKGDFRGVSRNVDSLTRFLSFRRLHSPRDFQRSRVVPPSIPHPARAKPCSVHLKPVSGLFDYAYSRLSCSVAWVSSRPPKFPAFSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF44</accession>
    <name>A0AAV6UF44_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_026064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000490">
        <property type="protein sequence ID" value="KAG8181906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF44"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="798"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="887"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="955"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="461"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="564"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="649"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="890"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1158"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1185" mass="135555" checksum="9A5F712EABE9AAA2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFT2</accession>
    <name>A0AAV6UFT2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tubulin--tyrosine ligase-like protein 12 SET-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000435">
        <property type="protein sequence ID" value="KAG8183034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFT2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057954">
        <property type="entry name" value="SET_TTL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027749">
        <property type="entry name" value="TTLL12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46088">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46088:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25556">
        <property type="entry name" value="SET_TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin--tyrosine ligase-like protein 12 SET-like" evidence="1">
        <location>
            <begin position="71"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="625" mass="73383" checksum="9CB59E60010E5E0F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UG50</accession>
    <name>A0AAV6UG50_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_029510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000430">
        <property type="protein sequence ID" value="KAG8183152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UG50"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000032">
        <property type="entry name" value="Transcription factor GATA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="295"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="349"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="393"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8183152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="510" mass="54366" checksum="39A17005AEE7F5F5" modified="2024-11-27" version="1">MERCPVPWSETPPPSSIPAPSQLHHPPPTDDPHNHMDQATSDTEGPTPTTSRRGSLQPASRTPTPTSSVPPDAIQLAYSSAVENDAVGGMTVIRGMKSLSPDESGHSPVGGEQLVYQTLGDSNGFIGQYAAASGVGYSTGGFSPAPVDPPSPYDKYSYVKVGTYAQGDVHMVQGYDPDGSRPLSPSNVVYTTYQYPSQEVPSSNAHHPMWGPLGNAGSSPYLTGLGSPIMESGDPNGRGGQGYAPYIGNSTYLLASGNDNGWSTLPPMGSSSYMQEGRRTQYIDPPPEYSRIPEPPPQHQCAMCGTTDSTPWRRDSAGQFVCNTCGIYKNGVGSRASAIRPPRRLTTSRRVGMTCSNCSTTDTTLWRRNTQGEPVCNACGLYYKLHQVNRPISMRKDSIQTRKRKPKSTGSSKTKSSNSSSSNGRNGSSNKSPLSQPSSSSGIYHHQMAEGGRLSPLLPSSAALSQQLPHFAPLDPHSPPEHIVLEHGLMLETSSGPSSVISMAPNHKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI80</accession>
    <name>A0AAV6UI80_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_002947</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000404">
        <property type="protein sequence ID" value="KAG8183794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UI80"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015842">
        <property type="term" value="P:aminergic neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17384">
        <property type="entry name" value="MFS_SLC18A1_2_VAT1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000145">
        <property type="entry name" value="Chromaffin granule amine transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="663"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="795"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="830"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="862"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="888"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="930"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="996"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1029"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1055"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1089"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="125"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="664"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8183794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1163" mass="126950" checksum="CA27C0F309A920F4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIC8</accession>
    <name>A0AAV6UIC8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000414">
        <property type="protein sequence ID" value="KAG8183548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIC8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="154" mass="17184" checksum="3EE24E4CFD716556" modified="2024-11-27" version="1">MPAAMRSPPTKVQCSIPNCVQIVPSTIRRSHARAATAKSLHQKSSARSLIVVQIVPSTIRRSHARAANAKSLHQKSSARSLIVVQIVPSTIRRSHARVASAEEQKNQVNTTIITTTTTRQHHWLYNAILQYCPTQCLPTFKTNISNCHNMYIYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJN4</accession>
    <name>A0AAV6UJN4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_018728</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000377">
        <property type="protein sequence ID" value="KAG8184322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJN4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004935">
        <property type="term" value="F:adrenergic receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15059">
        <property type="entry name" value="7tmA_alpha2_AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002233">
        <property type="entry name" value="ADR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF189">
        <property type="entry name" value="ALPHA2-ADRENERGIC-LIKE OCTOPAMINE RECEPTOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01103">
        <property type="entry name" value="ADRENERGICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="97"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="275"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="375"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8184322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="634" mass="70211" checksum="B4D49A222581EBF4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJR7</accession>
    <name>A0AAV6UJR7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_002308</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000372">
        <property type="protein sequence ID" value="KAG8184461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJR7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00782">
        <property type="entry name" value="MutL_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair endonuclease MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="205"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8184461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="417" mass="47113" checksum="50142E88056CC446" modified="2024-11-27" version="1">MAIILLDTKTINRIAAGEVIERPASVVKELVENAIDAGSSEIEIKIESGGRNLITVTDDGNGIEKEDLELAFMRHATSKLSDNELIEIKHLGFRGEALPSIAAVSRIKLSSKARGASEAWSISYEGGEKVGEVIPCSLLEGTYIEVRDLFFVTPNRLKFLKTERAETQAIVDIVNNLAMINYSIGFTLTSGNKKLLKYVKQTLLFNRLCEKEEFQSNSLEVKEEEEGIKLTGHICKPTISRGNSTQIYTFVNGRPIKDNLLVGAIRYAYHDFIPSDRYPFTALHLEIPYDQVDVNVHPNKSEVRFQNKKLLYEIVRRGIIKTLSTRFAAGGQGIEEELTFDDSKSQEQVNSEEKKNQKGFYEKRPSLLENHLMKEFNAPDERRQSLPETFKYGESLPQKGTIVLEREQIDLIEKPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJV4</accession>
    <name>A0AAV6UJV4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Metalloendopeptidase</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_004577</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Zinc metalloprotease. Provoques deadhesion of endothelial cells from cell cultures, and also degradation of fibronectin, fibrinogen and gelatin in vitro. Its role in the venom is not fully understood but it might act as a spreading factor that facilitates diffusion of other venom toxins. Alternatively, it might be involved in the proteolytic processing of other venom toxins or it might play a role in extra-oral digestion of prey.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="JAFNEN010000374">
        <property type="protein sequence ID" value="KAG8184405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJV4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF850">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11 12" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043105528" description="Metalloendopeptidase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="14">
        <location>
            <begin position="69"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="304"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8184405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="435" mass="48905" checksum="F1BDFB81DE3F3DAA" modified="2024-11-27" version="1">METLWKVTVAIASILINQCAVCEEFEGIDEKLQLTLLGSSETANGLRLLEGDIVQDKIDIVAGKPSSMKALPSKGGLWLERVIPYVFHETVNKSTGDVIQSAMMEWEKKTCLTFVPRTTEKHFLRFRTDRSGCFTFVGKKHTNGQDVNLGPGCEHLQIAMHEIGHSLGFYHEHSRRDRSSVLKILWHNIEKGMAGQFSPGNDAARNVPYDVTSIMHYNPMSFSSRLFEKNTMVTLDPRLQTLIGKYRGLTFRDVKLANIIYSCDDDCPNKGKLQCKNEGYLSPYNKGSKSCSCVCPPNTKGKTCETVTGDYYGISVCGGEILEERTIETPGYPNRNVNESCSWQIKAPNGRRVQVTFEDFSFRPRMDKPDNKYNGFCVYEHIEIRTSNKDEGQFYCGEDISPGTAMTSTTNHLLILIRADTKGQGRGLKARIKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJZ7</accession>
    <name>A0AAV6UJZ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enkurin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_008910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000386">
        <property type="protein sequence ID" value="KAG8184128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJZ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027012">
        <property type="entry name" value="Enkurin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052102">
        <property type="entry name" value="Enkurin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490:SF0">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490">
        <property type="entry name" value="ENKURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13864">
        <property type="entry name" value="Enkurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51665">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enkurin" evidence="7">
        <location>
            <begin position="174"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8184128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="271" mass="32286" checksum="21270746217E6673" modified="2024-11-27" version="1">MTEFQKILISKKFKEIEPHTENIYNLVPISTNEQTKRTLKYESIYSNLTKAFYESIKKPHQTMGYAEVSLKPPQEFLKKHTRETRPRPNKEEIHTRCLNSDHKKPPVPRRHEIPLILNENRNFIEQNRLNALRKPALKPAKKYADSRRGDTFFLEFSGLVPKFTRKQEFGKTPKYLVLRKKDLEDSKKAFQNSNAESKLIKLSHEERDDLLEGLRANWEYLNSKYITLPLKIDTKSMKTRKLDLERQLDLLEHDIYFLEKNEENDIYILPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKL4</accession>
    <name>A0AAV6UKL4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Locomotion-related protein Hikaru genki</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_010207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000385">
        <property type="protein sequence ID" value="KAG8184166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKL4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="174"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="274"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="333"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="392"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="451"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8184166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="55810" checksum="39511363A5FC3241" modified="2024-11-27" version="1">MEKFYGDTVTREGCLPPDVLVNGTSLPAGGAAAGGGAEDFTSVQEVQFLGVIGPLDQKRVCKIKCLNGVWVGPLCTIDQEGKKFQPMLRQCFLSPPPPDVLVSFDGRDLAFGEGGVGDLALPHGSVLHMRCSEVGMFKFVGESSVRCGNGQWNAPPPVCQPTSIQKNFSTEVAPTITYNVVSGDAGITKTGQIVILPNSIIHFDCLWQRQEGNPSWTWTATHRQYPTAWAISVEERGWKYRLSVYYAKETDDGIFTCTTPKGHSNEVHVRVRNIQCPTIDSLDRNRVMAVEGNTMHSQARFACMEGFNLIGPEEITCTASGAWSEAPPYCEVIQCQPLNLEDPHLRAGASNRSYGARVMFSCPPGYRLVGPPVIICLKNQTWSDVMPTCEAIECDPPLAPSNGRLLDTGRYLTGDFVQFTCNAGFVIVGESITVCNDQGEWTFPPPTCKPACEFPGEPAHGHVIPTKFHYDIGEMVQVECIQGFRVLGSRVLRCTSTGHWSSPLAHCRAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULU7</accession>
    <name>A0AAV6ULU7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000368">
        <property type="protein sequence ID" value="KAG8184601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULU7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="8762" checksum="FF7C268AC114E69C" modified="2024-11-27" version="1">MTEEVPCRSRLSNGMTSCRAARCPRRSDKEERRKSAAGRGRCHGDTRGFAIPRPTHARSDRPPTTTTHDPTTSAFATTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UM16</accession>
    <name>A0AAV6UM16_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_019748</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000334">
        <property type="protein sequence ID" value="KAG8185490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UM16"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000001">
        <property type="entry name" value="Fatty acid-binding protein, adipocyte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8185490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="129" mass="14311" checksum="A4B4BD72BA10136F" modified="2024-11-27" version="1">MANLLGSFKLVSSENFGDFLKEIGVGLVTRKMAETSKPTVEIKQEGAEYVIKTLAFKNSEIRFKLGEEFEENRLDGATVKTVVTLEGGKLVQKQFGDKEVTITREVDGDTLKVTCQSGTVVSTRVYQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNI8</accession>
    <name>A0AAV6UNI8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000343">
        <property type="protein sequence ID" value="KAG8185186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNI8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="11503" checksum="979DD830C1812C3A" modified="2024-11-27" version="1">MATPTHSEIISKAQRWQHQQHSSLLSKAQRWQHQHIQRFFQKLKDGSTNTFRDLSKAQRWQHQQHSELLSKAQRWQHQQHSELLSKAQRWQHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQL6</accession>
    <name>A0AAV6UQL6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THSD1 third Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_004444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000316">
        <property type="protein sequence ID" value="KAG8186024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQL6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038877">
        <property type="entry name" value="THSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056219">
        <property type="entry name" value="THSD1_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311">
        <property type="entry name" value="THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311:SF3">
        <property type="entry name" value="THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24311">
        <property type="entry name" value="THSD1_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043832091" description="THSD1 third Ig-like domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="THSD1 third Ig-like" evidence="4">
        <location>
            <begin position="233"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8186024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="718" mass="80514" checksum="4CCC946FB70549DA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQR3</accession>
    <name>A0AAV6UQR3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000330">
        <property type="protein sequence ID" value="KAG8185611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQR3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02636">
        <property type="entry name" value="R3H_sperm-antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034068">
        <property type="entry name" value="R3H_sperm-antigen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017330">
        <property type="entry name" value="SPAG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13498">
        <property type="entry name" value="SPERM ASSOCIATED ANTIGEN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13498:SF3">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037943">
        <property type="entry name" value="Sperm-assoc_antigen_PAG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="2">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8185611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="229" mass="26284" checksum="A401C2C278B03B36" modified="2024-11-27" version="1">MSDLLGSILSSMEKPPSFSGERNKLLQKQKKIIEKQQAAQKEKLTKFREKIEKDINEFIQDPLKQKHKYSPMDKVYRNIIHDVADIAGVCAYAFGEDEVDRYVMVFKKEFAPSEDELNAYRNGEEWDPIKAKELALLKEQQKLSEVEDSKKRKLEVEPTTNYAFKYEKLLGKESGVAAARIATPNKTFGFVSSELKKDQRSIEQTLADIQAKKKLKKDNDAQESTSEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UR81</accession>
    <name>A0AAV6UR81_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hydrogen voltage-gated channel 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_005741</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000282">
        <property type="protein sequence ID" value="KAG8186967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UR81"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="82"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8186967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="275" mass="31252" checksum="C2C49B6E0A81CE00" modified="2024-11-27" version="1">MMKATMQARAQCCILFSCFCSRKLVRQVGMEKSNEIHLGVESSNTNNGSSFSITTDTEEDPSIRPLMSFREKLCKLFESHKFQLAIIALVLVDCLIVIAELILEAKHHELSDKTLPHALHIMSIAILSVFVVEILMKIYAFRMEFFHHKFEIFDALVVFLSFALDIYFWEQEGIDLIIVLRLWRVARILNGVVMSVKTAADNKLHKEKRLREGLEQELTKCRTYATGLEQEVESLHSLLKKHGITEIPPSVVDKSQMGVTISVVAEVNKTAPESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URG5</accession>
    <name>A0AAV6URG5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_000394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000284">
        <property type="protein sequence ID" value="KAG8186921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URG5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="667"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="677"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8186921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="743" mass="86318" checksum="56A313BD1FB9A881" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URK9</accession>
    <name>A0AAV6URK9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000320">
        <property type="protein sequence ID" value="KAG8185926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URK9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="984"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1196"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1208" mass="134415" checksum="6B064AD199A40BE5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWU0</accession>
    <name>A0AAV6UWU0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000254">
        <property type="protein sequence ID" value="KAG8187931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWU0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="164"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="330" mass="36492" checksum="D62472E37372342E" modified="2024-11-27" version="1">MQSAMASEEGCVTMTWEIKNFDLLLKEDLFDSLLSPAWKIEETKGKKKDGLSDAWTVSVREVPCVEGGISSVSCSMKACNGINLVKGAMDVTDLEGYTRFIMMPDKDLNIALQLELMIAYHRVCQGQLALHSPTKIAGHKNVSGEGSCSLGRDFLHLYREGMLSDVTLHAEDPRRSFSAHRSILAARSPVFRAIFEESSGGQSVDMDGVDSETVGRMLVYLYGHSLEDLGWREASALYCAADKYGVVRLKEKCAAILEACLTADNARDMLVLADGCSDKALVERVVLFILDHEEVVSSAQWEELERDNSALAAKIVKQLFLRRGKRMRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXQ1</accession>
    <name>A0AAV6UXQ1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000248">
        <property type="protein sequence ID" value="KAG8188116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXQ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="13801" checksum="4ACE37AEA57057F1" modified="2024-11-27" version="1">MTSPARQTAGSLSVSRTRTWSEGHAQRFQGRGPPFRGREGSMSGFIREGRAHPFSRHPLDDGIGWPRGSVVDTGVFNLAYRREPWMLGFRVVFVNPCFAGVAESSWSGSASGIFEGGERRSVQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYE4</accession>
    <name>A0AAV6UYE4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000216">
        <property type="protein sequence ID" value="KAG8189415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYE4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="8112" checksum="9C0341B1C44A83BE" modified="2024-11-27" version="1">MEFNDETSSAFLSHSSPQIPSCHPVDPSSLSCRSLLVCERVEQKYRKLYSISTTWNENICTAYKFSLSHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZ54</accession>
    <name>A0AAV6UZ54_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000207">
        <property type="protein sequence ID" value="KAG8189670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZ54"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="9289" checksum="86BA8C873F198CD1" modified="2024-11-27" version="1">MNARRRLDCNHQKVKLVVKMTFQDLFMGAVRVERGERLLRKFIHWERRARVENTQVDTVRHRRDEAWTFRYLSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V055</accession>
    <name>A0AAV6V055_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000200">
        <property type="protein sequence ID" value="KAG8189892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V055"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="140" mass="15828" checksum="DFEA5173781F5956" modified="2024-11-27" version="1">MSTLLGQTKHWKRRLQKICRWGEGVGSILEKEAQDENKDWERQEGRMQRDEAVFRDCCALIRPQGGHLSFGKVECLRDNPDLEHLPGVVCVGMCTTWCFRIGETIGQIGGLDLDKGGVESGQREEDDLSGQEKTPPRNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0P8</accession>
    <name>A0AAV6V0P8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_026601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000212">
        <property type="protein sequence ID" value="KAG8189557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0P8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040362">
        <property type="entry name" value="RELCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32059">
        <property type="entry name" value="RAB11-BINDING PROTEIN RELCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32059:SF0">
        <property type="entry name" value="RAB11-BINDING PROTEIN RELCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8189557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="43033" checksum="4F75181A9AD1986E" modified="2024-11-27" version="1">MADNLESAGEMSLTIPIDVPKSDCDKNLKSDQEEIKESTLDKLATKLLKNNFILTALELHTELVESGRELPRLRDYFSNPGNFEKHIQETEISPVLPRTSSVQTFDSLDFTRYSDDGERQVDERVAVLEFELRKAKETIKALRTNLTVATESDPNTPTSASSKCVAQESVKPHEKRALNFLINEYLLYNSYKLTSITFSDENDDQDFEDWDDVGLNIPKPQNLLQLYRNYNKYIYLNNEVFNKETQTDAPPTVEKPDVCTVESCGLEKTQLLEKITKLTYERDELAQMSEDKEKFEQLVKSLKRELNMLKMSSTVENTEKSSHFVSADDKKSLDSADAQEYVIVQKHVENPVAINSDMMREDSESPGLNQNPSSTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1P4</accession>
    <name>A0AAV6V1P4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_008458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000213">
        <property type="protein sequence ID" value="KAG8189496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1P4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19723">
        <property type="entry name" value="bHLH_TS_ASCL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000029">
        <property type="entry name" value="Achaete-scute family bHLH transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="98"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8189496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="223" mass="24531" checksum="6986E925891BD145" modified="2024-11-27" version="1">MESTLAMRAAVAFDGRCRSRGDAEGVRHPYGVGRFVDPAAWMGAVVQQRRADGPPPKYRPEVPQALLASDPPGSQLPSPMHPLGHQQQQHKGPFVTNNAMARRNERERKRVRLVNHGFATLRQYLPQGNSRKKLSKMETLRSAIEYIRQLQHLLDPVTSHFDPNSAHAEWQSAMTSDSASGSAMGAWEEAMGWASQRSPGSAGSSPQTSLSPDTDLIDFSSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2E6</accession>
    <name>A0AAV6V2E6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_006687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000182">
        <property type="protein sequence ID" value="KAG8190522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2E6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10974">
        <property type="entry name" value="CE4_CDA_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000003">
        <property type="entry name" value="CLUMA_CG003232, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF6">
        <property type="entry name" value="FI03450P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043910833" description="Chitin-binding type-2 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="4">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8190522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="533" mass="60241" checksum="F6BA15140EDCB0E0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4B6</accession>
    <name>A0AAV6V4B6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_018551</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000156">
        <property type="protein sequence ID" value="KAG8191622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4B6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000015">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000064">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043764727" description="Cadherin domain-containing protein" evidence="13">
        <location>
            <begin position="24"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="30"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="151"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="276"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="369"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="476"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="589"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="734"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="840"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="951"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1049"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8191622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1111" mass="123857" checksum="3C44B3F391C795D9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4M3</accession>
    <name>A0AAV6V4M3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000155">
        <property type="protein sequence ID" value="KAG8191624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4M3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8254" checksum="28CCC9CADCD7032B" modified="2024-11-27" version="1" fragment="single">GRSKESVTEIEQLVDEPLEELLPTEEAPETSKNIDRLAEQESGPSNRGQAKSSQSKACIKPIQAKRFIKKITYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V560</accession>
    <name>A0AAV6V560_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_019810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000150">
        <property type="protein sequence ID" value="KAG8191875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V560"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02904">
        <property type="entry name" value="Macro_H2A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000013">
        <property type="entry name" value="Core histone macro-H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.220.10:FF:000002">
        <property type="entry name" value="Core histone macro-H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035796">
        <property type="entry name" value="Macro_H2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Macro" evidence="11">
        <location>
            <begin position="189"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="121"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8191875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="372" mass="39894" checksum="CD5FBC3D0C609856" modified="2024-11-27" version="1">MSGRGGKKSKKSTSKSTKAGVLFPVARFARYLRNNTHHQRIGALAPVYTAAVIEYLTAEILELAGNAARDNKKARVTPRHILLAIANDEELNRLLRNVTIASGGVLPRIEPELLAKKKGNKFATMPSPRSNPPSPGPVVVAKKSKPNYTSPGTRKNTRKPAASATGKGKGKGKAGKDNPNTATASGAFTMLSEKKLFLGQKLTVIQGDIIKVTADALLHPTNSTLSMNDDVGQALEKSGGKEFQQEVKTLSSNLPLEIGNAVICPGHNFLAKYVIHCNLPAYGPANAPEQMEKAVKNILTLADEKNLKSIVIPSISTGASSFPKQQAAHLILKGISNYFVNCMSSTLKQIYFVLHDMETIGVYTSELAKLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5F2</accession>
    <name>A0AAV6V5F2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000165">
        <property type="protein sequence ID" value="KAG8191135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5F2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="10207" checksum="A3F613584F3D1638" modified="2024-11-27" version="1">MEYPQRKKPFFKRPRKLPLSHRYPKTFYFSIVGVSLLVFFSKPIYDTIYHPPTVDYFALEPEERRRLVDEQRRKGGFIVPLRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5G1</accession>
    <name>A0AAV6V5G1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_010316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000172">
        <property type="protein sequence ID" value="KAG8190891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5G1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8190891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="368" mass="42420" checksum="E3D6AAD4B3B0499B" modified="2024-11-27" version="1">MEEIPLELFINAVLSNYSLENSSYTDNLFENDESLPYYGEYLARFQSQYILYHGYLTLAFCIFGITANILNIIVLTRRKMISPTNAILTGIAVADMLVMLSYLPYTFHTYIRTEISDIERYSYGWTLFTLFHSLFTVVCHTISTWLTVTVAIWRFLFISFPQNASIWCSMFRAKWAIAMTYVFSAIFCIPIYLTFTVYVFKSTAGDIMYRVDFSEIASQHNRLLEKTNFWIFSVITKLVPCVALTGISLGLIKVLYERNKRRQILKGSANNDKHHDRTTRMLLAVLLLFLFTEFPAGLLSLLSGILGSDFHQHVYMNVGEVMDALAMINSAINFIIYCSMSQQFRNTFALMFFPRFFKTALHSVTASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6G6</accession>
    <name>A0AAV6V6G6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000154">
        <property type="protein sequence ID" value="KAG8191678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6G6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="118" mass="13161" checksum="1EE8041EE0E3D579" modified="2024-11-27" version="1">MSSRLFLSLYRGLVRPQVTPNSSFSTSSISLKILGDKMTEFKDSVEKDGKKLVEKAEAELEKAETELEKAEDKMAEVHEKYDNDIGGFLQNAEDDIEAISESVEKKSKGQTDAVEDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V781</accession>
    <name>A0AAV6V781_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000146">
        <property type="protein sequence ID" value="KAG8192062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V781"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7901" checksum="2FF40140F86949C6" modified="2024-11-27" version="1">MAQNFPILQSQGAHSRLRAAPEMANIDTPFIWDWTEVNRGSITRKDLEQVLISDWVCFFPSHGKSNELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7P4</accession>
    <name>A0AAV6V7P4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_019827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000150">
        <property type="protein sequence ID" value="KAG8191893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7P4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043395046" description="C2H2-type domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8191893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30890" checksum="2FCB4F2C4ADB1754" modified="2024-11-27" version="1">MSETKICLILGLTLLQSHSDQQVYVLFKLPKVSPGTTTQPAPVSENLAHLDISKGKGLKKTINLPRSSLATIKEKKEYLKKCLNCGVTYTSSYWFSKHSKDCILKKPSLGSIPEGLSLLTKPPSMSEGSSCMAPQDVVKESSDASPTSMSEGSSYTAPDDVPVESSDRNPLSLSDVVSENVSESSSDVVPTSSPENKTGKGITYPRQCSRCKKFYRNKDCFRYHLQKSNDCRYVYFIAGKSDPLRNSIYPRKCLVCCRTFASRSGFCMHKRKCKPYESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7Z1</accession>
    <name>A0AAV6V7Z1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7Z1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="7870" checksum="BC05813F3DD2CC4D" modified="2024-11-27" version="1">MSSCTNSFIYVLLNKHYRDAYGQLMCLLKHTGSTTRSTSCEGALDASRTTHLRGEDKSNQSQLSVSRELAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8A8</accession>
    <name>A0AAV6V8A8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Zinc finger protein DPF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_018024</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the requiem/DPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000139">
        <property type="protein sequence ID" value="KAG8192501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8A8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15619">
        <property type="entry name" value="PHD1_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15530">
        <property type="entry name" value="PHD2_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000005">
        <property type="entry name" value="zinc finger protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025750">
        <property type="entry name" value="DPF1-3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF5">
        <property type="entry name" value="D4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14051">
        <property type="entry name" value="DPF1-3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="308"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="365"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="166"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="232"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8192501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47854" checksum="C3E5201709455FA8" modified="2024-11-27" version="1">MADETLSVRTEYLERLKSILSDSFYKDAMEHAASYNTRLCLERKMRLPFLDQQTGVAQSDCALWMHKWQRMPGKTDGQLYSYPARRWKKKRRQYLMNNFYLARRMKEVESSEAENHQSTNENSMSGVQENENGADKVAEDSKDSWYKDFDDAAETFDMVAEVDDPDTDVEDYEETYVRKKKKKIRATNRKSDQSSRGRKRADRYDYTDLEKPYVCEICGARYKTRPGLSYHYSHGHNNDSTDNTEEETNYTPPKPSAAPPPPAPAPPPLAPPPQSMQPSMSSWPGPSSTEDGPLTPRPPSEKGNTLPSTYCDFCLGDSIENKKTRMPEELVSCSDCGRSAHPTCLQFTPNMTASVKKYRWQCIECKSCGICGTSDNDDQLLFCDDCDRGYHMYCLTPPLSEPPEGSWSCHLCIEEYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8X9</accession>
    <name>A0AAV6V8X9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000138">
        <property type="protein sequence ID" value="KAG8192548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8X9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11472" checksum="37F23C41A7C72E77" modified="2024-11-27" version="1">MRSEKSITTNNQGDTEGSPQRKKPAPRFTDGEDEFREEYLPMSFYTQQIRAASTANTNPSSAVGENSDSYSNSEDTQIYDLEGNEVQGATASTPITHRDKKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V972</accession>
    <name>A0AAV6V972_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histidine ammonia-lyase</fullName>
            <ecNumber evidence="3 9">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_009745</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>L-histidine = trans-urocanate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 9"/>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V972"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006548">
        <property type="term" value="P:L-histidine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000007">
        <property type="entry name" value="Histidine ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000003">
        <property type="entry name" value="Histidine ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021922">
        <property type="entry name" value="Par3/HAL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006871">
        <property type="entry name" value="PRK09367.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12053">
        <property type="entry name" value="Par3_HAL_N_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Par3/HAL N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="631"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8192722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="710" mass="77534" checksum="55B400F2C94454B2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9R7</accession>
    <name>A0AAV6V9R7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000134">
        <property type="protein sequence ID" value="KAG8192848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9R7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="205" mass="22843" checksum="DF1668C62E38D4E4" modified="2024-11-27" version="1">MKINGVSVPDAFVQANCLAELYRSEEVPGGIPFSLAGEEGAWYNRSLSLSGRGRGEGRAIPEVSNIKILGIFSKTLSFTYYFTNLQMKCLKKLNAVRVLASTLGGARTKFLINIINSTIRSSLEYGCQVFLTTNKTDPRKLEVIYNQGLRFACGLPKWSPIPVTFAEANEPPLRTRLQLLAEKFVVKQAALKFGQLDLHRNHNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAQ3</accession>
    <name>A0AAV6VAQ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAQ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="10040" checksum="A122213BC7942930" modified="2024-11-27" version="1">MLNLLELLSEDAGSLRHDVVEMAKSQWSKSGRASDMKVSRGHGRPRIEWKRKEDADGADLDLCVKVGCSFCHGTPSIQDRIDSPWVIEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBP1</accession>
    <name>A0AAV6VBP1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000111">
        <property type="protein sequence ID" value="KAG8194014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBP1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="329" mass="36349" checksum="19FDE22CAF932A0B" modified="2024-11-27" version="1">MENSKSIQRTQINRNDSFYKIYVSSSPFKTNNAQSQFFNIDSNSPQCIRCGRDMKGFQSVFVTICLPNMQPKSEKGMASNIPSFRKQSSFAGMGQRNIIDTDDVSSSDGNPISTISINIRSTDGSCPLCQNNTSFTSQPEIDYVSRIRYHSGTCNDSNDSGESSTGNIASPSSPERYPISDNVGCKFHTPVISNVESSDEILSNLSNKDQFVANESLHSTSRGIPNDRDGDIFTHPARRLENPIKTDIIKKFEIIADTSFTPCNDCHVAVVDATRPSDDDQQTVCLMFQVSNVTDITEAYLRKYECHLPSNIDVGIGVNPDVLVDNGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VC17</accession>
    <name>A0AAV6VC17_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Selenoprotein P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_028389</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000110">
        <property type="protein sequence ID" value="KAG8194047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VC17"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008430">
        <property type="term" value="F:selenium binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001887">
        <property type="term" value="P:selenium compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007671">
        <property type="entry name" value="Selenoprotein-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037941">
        <property type="entry name" value="SeP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10105:SF2">
        <property type="entry name" value="AGAP003297-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10105">
        <property type="entry name" value="SELENOPROTEIN P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04592">
        <property type="entry name" value="SelP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043955753" description="Selenoprotein P N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Selenoprotein P N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8194047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="459" mass="52001" checksum="885702A7F8B0311B" modified="2024-11-27" version="1">MGVHRWLLGPVICLIVAQASSLESLRKHFRTYGMTDLRFMIVNSNLQHAQQIVHELQNRVSFDVHQDTKENNVWGLLEGGKDDIYVYDRCGRLAYYIPFPLSIMNHQEGDLVTSAILATYYRSPCGTTCDKNSSTLEDFLNKAAVEESPVDSTTEEAVVTTELSPNPTVDAVSTVESDSSLLEEGVESKANESYVRYDYPTYDETLEDYDDNETDTKHDHAFFNSLYSFFFNSTREVSNTNETLSSNASLTDTNHDQTFHNSLYNRIVKPDTTEKPKVKDEEMNQISAPLNISDQIISESLNNTTPADTESTTIRTLKPKPDRCAEADQSVCRTWSKKRLLRAHDCCSTIEDESSHQMLRYCKNFGKKRCKKIKTILKCCIKTSLFETTTIPIPTDEEDTVATTTVQPVTTSVNEIVCCRDVEEGKLCRVSEEPTCRLGEYLQVDNPEVEEAPREDKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCP1</accession>
    <name>A0AAV6VCP1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_013283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCP1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043809471" evidence="2">
        <location>
            <begin position="22"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8194535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="307" mass="34247" checksum="460311B17FCC1CB0" modified="2024-11-27" version="1">MWMYRFAVVVVVCLTCKETHSLELEEFLSSLSSKKDENSSEEIQEISDISQDQLLKIAKRSGMMAQPQPISSNDALSNEKLLQMLQQLQSMNNKQQNLPVYSPEYVQPLSQMSKAQRSHRALDSSQSSNINGNNAYSYLKPNSMPLTQDQQNSIQSQQQTQYRYNPQYTATAIQKHTSQAKSMHPATSNQRETNKEDRQGHYPYESQAHDSGYSYGHGQARSPVYAHESQYSHPEPVHKSILPIPQLSIKFDPLGLLKLLLSGLPRPLFNLNGKIFLGLELGKGAGLTVGAGPAPHYGGSKNLITIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEF8</accession>
    <name>A0AAV6VEF8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000110">
        <property type="protein sequence ID" value="KAG8194028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEF8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="384" mass="43624" checksum="37E6655F85C216F4" modified="2024-11-27" version="1">MAFPFEDRPIPPERVIPNVMSVIQHMQQVQENVDNAIHNHNLRDASNLVHGRIDNQLRNASQGISICIDRLQRIWADRANRPFPRDDENIRHDPDDYQLVIENVHRGVAQPASPTEISLKKPSSPKKPSSPPPPSPPRNRGSGQNSRSGSPVDGQNQQPIEVIVVEMRDLPVQQRVEVQAPADIVNRPAFPLSEEDDLYAEPKRKRVAVETQKQEQRVPPMTVAAHEVDTIEVLPQSPPRIALSQHPGAALEQRTAGGPMRIRRWLRPASPEHRETATARQGGQARNNRASSSKPYKRPERLANYRLHNPASQQNTAHFEHQWRTDFVAQAWRHEPDLELKEFPEVQRVPAPLRRLGCQFLPDVPVRRAGALRRSQRLAAQRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF04</accession>
    <name>A0AAV6VF04_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_026396</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000099">
        <property type="protein sequence ID" value="KAG8194751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VF04"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043944447" description="acid phosphatase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8194751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="427" mass="50105" checksum="77602D0E032B4FE2" modified="2024-11-27" version="1">MKLLLFSLTCVLCQVQPIFSAQNSKLLFVQFLYRHGDRNPINLYPNDPNPESAFKGGLHQLTLLGRKQHYALGKHFRSMYRNFTTFSPYEIAVVSSYADRCVMSAETNLASFFPPNSEWSFENNVNWQPIPIRYLPKAEDKYLEDDSYCPRADEEEKRILYSPEGQQFMAEHKEMYENLTLMSGKDLANWTQASYFHDTIFIEKKYNLSVPSWVEPYYEELTNVSNLAFFWTFNSPLMHRLRAGPLIQRLINNMNDKIAGTLKDLKFQVFSAHDTTIAVVLDALNLFNMIQPPYASTLLFELHEMPNGANALRMLYMNSSRPEERIEEPHVLILEGCSEFCPLSYFINYTKDLMPEDWEQECKLDKTLAEKIKDQKFSIYWLFLFVGVVIASIGVYAVWRIYSRKQDKQKKLRDYLWPEDPAYSFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VK38</accession>
    <name>A0AAV6VK38_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sulfite oxidase</fullName>
            <ecNumber evidence="6">1.8.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_011333</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Energy metabolism; sulfur metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.1" evidence="6"/>
    <dbReference type="EMBL" id="JAFNEN010000058">
        <property type="protein sequence ID" value="KAG8197175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VK38"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02111">
        <property type="entry name" value="eukary_SO_Moco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.650:FF:000002">
        <property type="entry name" value="sulfite oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8197175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="568" mass="63566" checksum="5AD4AF23F2D67E46" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLA9</accession>
    <name>A0AAV6VLA9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_013137</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000061">
        <property type="protein sequence ID" value="KAG8196993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLA9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8196993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="271" mass="28916" checksum="9EE3081CED12894D" modified="2024-11-27" version="1">MGGQANIFVFLSVRRVTVSGIGGFRENTGCTVVSESLSSLQGLGLELVLTFVVAFTMCATHDPERKAMGSDSLAVGLAYLVCTLIALPATGASMNPARSLGPAFVSNTWTNHWVYWAGPVLGGLLAGLIYEYIFDSPKKVLPVIKDREDSERDTSDAKDDTDSKCSSALSPRTHLPQSQMVVQPTTSASGGPYYRPLTPHEGPTRPHSRGAYSSAKYIASPQPSGHQQHSQAATTYYSTMPRGSSSAGSVNGACGGYRSWNDYGNSTQFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM36</accession>
    <name>A0AAV6VM36_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM36"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF237">
        <property type="entry name" value="NEPRILYSIN-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="230" mass="26318" checksum="F1F25E13DD8CD49E" modified="2024-11-27" version="1">MGNFYYSYRDSATNNPTVMNAFYAPYSNFIALPSGIFGYPYYKYGRIDSINYGGIGTVIGHEISHAFDTSGRKYDHIGNKRNWWTNETLYKYAEKAQCFIDQYNNFTDPLSPVKANGRVTLKENIADNGGVKSAFKAFRLHLALSGEYFSYRKRLPELPASPEQLFFLGYASIWCTNMSDELAKRYNEFDSHSPSKIRVNVPLSNFKEFAKAFKCKAGSPMNPIHKCNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQQ0</accession>
    <name>A0AAV6VQQ0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQQ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="160" mass="17432" checksum="22626C7BB5D4F651" modified="2024-11-27" version="1">MPLNFATKVGSEGRGRENNGHVSSSKKWHSSGQLKITPKKSGLPFGGCSFLLCLKNTPWEDADKGCGEEGDAREDRWVAWLTVHGPPRWAVKPGDKSSVAANGWRREICLLSLGLLSTRRSDFDHEAPAASSGLTRLGQNTISCEAIIDPGRPHSHLQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VR36</accession>
    <name>A0AAV6VR36_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calponin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_026436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the calponin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VR36"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21207">
        <property type="entry name" value="CH_dMP20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001997">
        <property type="entry name" value="Calponin/LIMCH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF24">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00889">
        <property type="entry name" value="CALPONIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="24"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8198533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="186" mass="20925" checksum="29EE954D02A5CC3D" modified="2024-11-27" version="1">MSYRGPSYGLSAQIANKIAAKRDKQLEAEVLEWIQEILGEALPNGSYEEILRDGVILCKVVNTLSPGIVKKINTSGGQFKMMENINNFQEAVKKYGVADLDVFQTVDLWERRNIPQVTQCIMSLGRACYLHPEFPGPFLGPKPADRNEREFTEEQLRMGETIINLQYGTNKGANQSGQNFGNTRHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRD1</accession>
    <name>A0AAV6VRD1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000029">
        <property type="protein sequence ID" value="KAG8199244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRD1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="111" mass="12392" checksum="40B82A8874996F1A" modified="2024-11-27" version="1">MNIARQALASDLIIGGVSFITAPRPPSLAECRLACDSIIYYRDRGETIGMSHPSPCPHEHGLPSRRRRLVISSSNQPITHRLKVNHDSVHTSSELDSLKFNTTRITRSEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRI9</accession>
    <name>A0AAV6VRI9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor COE DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_021621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRI9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3180:FF:000004">
        <property type="entry name" value="Transcription factor COE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3180">
        <property type="entry name" value="Transcription factor COE1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032200">
        <property type="entry name" value="COE_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038173">
        <property type="entry name" value="COE_DBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003523">
        <property type="entry name" value="Transcription_factor_COE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018350">
        <property type="entry name" value="Transcription_factor_COE_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10747">
        <property type="entry name" value="TRANSCRIPTION FACTOR COE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16422">
        <property type="entry name" value="COE1_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01345">
        <property type="entry name" value="COE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Transcription factor COE DNA-binding" evidence="3">
        <location>
            <begin position="44"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8198376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="260" mass="29000" checksum="AD6D926719B536B7" modified="2024-11-27" version="1">MMFGLPDSGLQPRGPMATLKEEPLTSAQLGSVRTGWIQPAMIDQTAGSVGLGRAHFEKQPPGNLRKSNFFHFVIALYDKAGQPVEVERTAFVGFVEKEQEVEGQKTNNGIHYRLQLLYANGVRQEQDLYVRLIDHVKREAVPYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDREAKQNDNHSNLATPPEITLVVRGAPTDNGVACHPAFIKRQIDTGAPRLLHQRPSSNWNPCHSQTPLPPQTESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUC9</accession>
    <name>A0AAV6VUC9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUC9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="108" mass="12443" checksum="10FA2FDB78954116" modified="2024-11-27" version="1">MRCDHATEFHGTGSVPALLHPSLSLPYPQEESSRDEAQFLARTHMQNSPPYMQSRLNDRDEGMFAVVPANRFCYVPAIVDFQIRVGYNTAFHSIHTWSRVLRSFFQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVB3</accession>
    <name>A0AAV6VVB3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_000822</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVB3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016402">
        <property type="term" value="F:pristanoyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000007">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000010">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF390">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="153"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="16">
        <location>
            <begin position="300"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="14">
        <location>
            <begin position="507"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8199726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="695" mass="79242" checksum="B8757F39D349954F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVX1</accession>
    <name>A0AAV6VVX1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Adhesion G-protein coupled receptor G6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_006399</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000013">
        <property type="protein sequence ID" value="KAG8200820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053066">
        <property type="entry name" value="ADGR_G7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767:SF1">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043989354" description="Adhesion G-protein coupled receptor G6" evidence="8">
        <location>
            <begin position="28"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1393"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1432"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1462"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1505"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1543"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1593"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1618"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="267"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="692"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="846"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="10">
        <location>
            <begin position="1228"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="11">
        <location>
            <begin position="1395"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1668"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1671"/>
            <end position="1687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8200820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1705" mass="194085" checksum="BA9C5808B601517D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VW18</accession>
    <name>A0AAV6VW18_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adenylyltransferase and sulfurtransferase MOCS3 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UBA4 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-like protein activator 4 homolog</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.-</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">Sulfurtransferase</fullName>
                <ecNumber evidence="11">2.8.1.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_015784</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="11"/>
    <dbReference type="EC" id="2.8.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JAFNEN010000012">
        <property type="protein sequence ID" value="KAG8200880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VW18"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000014">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028885">
        <property type="entry name" value="MOCS3/Uba4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004281">
        <property type="entry name" value="PRK05690.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="340"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="11">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="11">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="113"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8200880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="439" mass="48358" checksum="A5EFC61FB5F7F93D" modified="2024-11-27" version="1">MEEEIKRLKHLISQRDAEIARLNSLLENKVDFSNYFSEKLEANPSLTLTSDEISKYSRQLILPEIGVEGQIRLKQTSVLIIGAGGLGCPAAIYLAAAGVGHIGIIDHDVVDVSNLHRQVAHKYSSVGQSKSESLKNSLKNLNPEVEISTYSVLLSSENIKDIIKPYSILVDATDNVPTRYLLNDAAVLYDKYLVSGSALRFEGQLTVYNYKDGPCYRCLFPKPPSAGAVTNCSESGVLGVITGVIGCLQALEVIKIAVGLEPNYYKKLLLLDGLGGRFREIKLRSRVADCNVCGQNPTITELIDYEEFCNLPATDSNANVSLLSESDRISCSDYKKIVDSGRKHVLVDVRPSNEVAICSLPNSVNVPMNKIALPATAEKLKDLVEMLDCKDNFVVCRRGNDSQKAVLELRKLVSQSVWQDIKGGLHAWHDEIDPTFPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VX46</accession>
    <name>A0AAV6VX46_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000010">
        <property type="protein sequence ID" value="KAG8200995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VX46"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="111" mass="12521" checksum="9B00E0DE59C6F096" modified="2024-11-27" version="1">MVIRTATISTPHPQARPQTSKNHSVPRVAKKKKCQPDETLQGHSNVPDKYVMTLRRTGHCPEWPRKDKEEEDAGVKVWSCFEIGHSMGVIHLRGIGHFGLGKWGFFGGMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYI7</accession>
    <name>A0AAV6VYI7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cleft lip and palate associated transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_027264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYI7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF14">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="604"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8201779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="73120" checksum="F7AE69D268C54B10" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZE8</accession>
    <name>A0AAV6VZE8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Down syndrome cell adhesion molecule-like protein Dscam2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_002743</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000009">
        <property type="protein sequence ID" value="KAG8201069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20956">
        <property type="entry name" value="IgI_4_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000017">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000104">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000719">
        <property type="entry name" value="nephrin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056754">
        <property type="entry name" value="DSCAM/DSCAML_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25059">
        <property type="entry name" value="FN3_DSCAM-DSCAML_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1292"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="17"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="116"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="228"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="321"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="412"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="509"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="600"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="695"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="792"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="893"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="994"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="1178"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1370"/>
            <end position="1396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8201069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1564" mass="173516" checksum="E427F033B5B3FEDA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W1A5</accession>
    <name>A0AAV6W1A5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W1A5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="109" mass="12258" checksum="A74924CF53479A4E" modified="2024-11-27" version="1">MDSNSQSQERASKPLRLKLNMEEDDIRSWKTPGFPISNNTTICVDTFATFYEQSVVLLTLVSDIFSQFREIVSGDQWGWGTRDPPWARVGTTHSGAISPSTPANLVFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W4F4</accession>
    <name>A0AAV6W4F4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histone acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_027462</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W4F4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043992">
        <property type="term" value="F:histone H3K9 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015019">
        <property type="entry name" value="LAMTOR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009464">
        <property type="entry name" value="PCAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08923">
        <property type="entry name" value="MAPKK1_Int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06466">
        <property type="entry name" value="PCAF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01278">
        <property type="entry name" value="MAPKK1_Int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 15" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="386"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="16">
        <location>
            <begin position="620"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8201993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="839" mass="96258" checksum="934D0701E6D239AA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W646</accession>
    <name>A0AAV6W646_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W646"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8202091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="11639" checksum="7DFC2ED933321323" modified="2024-11-27" version="1">MPLIIQPLDKKPLITYLPTTEVTVPPNNTKGSIDQQFTLPPRQRPPNLNGNRIRLLTTGAKEARCQMQRSITGSYANPGLFKPTFHSKIDSPSLTAHLSLINAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCM9</accession>
    <name>A0AAV6TCM9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007615">
        <property type="protein sequence ID" value="KAG8155651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCM9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8155651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11284" checksum="C16326B08195E589" modified="2024-11-27" version="1" fragment="single">MEFSSSTRVYLYIGFDGKRPGKPPAIPNFQPQSAQTRPGRSCVTFIPRPTTCLDFFKWPYLATERAKVFSDPQWTVKVGQGLLWHGARFSIVSKTVSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFK7</accession>
    <name>A0AAV6TFK7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005173">
        <property type="protein sequence ID" value="KAG8170588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFK7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9656" checksum="9180DB5618320688" modified="2024-11-27" version="1">MKSPTGSRDMVKTRKSVEHRQNAKVSSTVNVYRNMVKTCLRHMVRTRTIYEHRTRKSVERLKLEKVSSTVKTQKSRAHQKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFS6</accession>
    <name>A0AAV6TFS6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005316">
        <property type="protein sequence ID" value="KAG8170512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFS6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="188" mass="20154" checksum="47387EDFDB2A3797" modified="2024-11-27" version="1" fragment="single">AFPNPDDPQVRIANPLQREVDDCLQMTKSWRKQLQMARTMCTALERLVVQPIGMGTVEHVRTSTILQGALTSRAGVIKGDGGNSSFLPVSSALSPAPVEVILSTSPALTSPNSPGNTDGLTQATNLPPPTTTLVVPLQSSGPYYIVTQGKYQENGDTLSDFVNLVCQEAQNSNTSSQVLYFNSFELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TI08</accession>
    <name>A0AAV6TI08_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003883">
        <property type="protein sequence ID" value="KAG8171507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TI08"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9657" checksum="F50820AB73B4D3B6" modified="2024-11-27" version="1">MGPSVLRYRRNPFRSETSAQTQTHARVVSLPTERNGVNSPQPGHGRWSFGPSAVTQPNSETSTEDPGKVYLFLCKKFVSPDRLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIU4</accession>
    <name>A0AAV6TIU4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Recombination activating protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003490">
        <property type="protein sequence ID" value="KAG8171840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIU4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="6615" checksum="AFDA61E27ABB95CA" modified="2024-11-27" version="1" fragment="single">MWIQDKEFEVEIPIDSLVSTAGLTVLQPPQCEEIEDHELAAIQGCSIFIAGVNHSITVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJD6</accession>
    <name>A0AAV6TJD6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003459">
        <property type="protein sequence ID" value="KAG8171865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJD6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="64" mass="7260" checksum="929B9CEC046DEAB2" modified="2024-11-27" version="1" fragment="single">GAKVFGRFVPFDFAVVYGHGGLAHSPKRIWPSLQKIHEKLTSFERARGMGRNSTSIYGEEFYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJK4</accession>
    <name>A0AAV6TJK4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003357">
        <property type="protein sequence ID" value="KAG8171940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJK4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="8885" checksum="C852391C26B5E3D5" modified="2024-11-27" version="1" fragment="single">CIKARNRGPDLGKKTPPKVGELSLCDGSIDAASLIRGKSSCIQRNLNNAFLSPPGGQFLCQLSVSIPKAICQAKLMDDVASQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TK66</accession>
    <name>A0AAV6TK66_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003377">
        <property type="protein sequence ID" value="KAG8171926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TK66"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10883" checksum="77611FF3A72C678B" modified="2024-11-27" version="1">MYPEDLEPVFVDECLHLKPFSVQNTPKEKRSITLTGIINVLPHFDAVEIYPNRNIALGMVLSAPATNCTGERSFSTLRRVKNYLRASTSHIDVIIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKB2</accession>
    <name>A0AAV6TKB2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002967">
        <property type="protein sequence ID" value="KAG8172210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKB2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="7972" checksum="356290515F5515C9" modified="2024-11-27" version="1" fragment="single">KKSSVDWSDMRQRMRDRRNAASKACTCCTVFANAASKACTCCTFFASSVFLCFFYVAVIYGVSIAMVVIVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLS0</accession>
    <name>A0AAV6TLS0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002736">
        <property type="protein sequence ID" value="KAG8172411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLS0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8363" checksum="8B4DF080C1C30557" modified="2024-11-27" version="1" fragment="single">IPYLKGGCMGFHWIYSLINELKLLKIFSLLLGGIRTWNDDSWRNLKVFHYINPPELAADEFRRSGLVVVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLV9</accession>
    <name>A0AAV6TLV9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002196">
        <property type="protein sequence ID" value="KAG8172962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLV9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8420" checksum="A6B2B95CC69A2BE0" modified="2024-11-27" version="1">MDFDMLIFEDNLGTVWMPPAIPVHDPRQQLPPQRQPAYGDPREYQMPPAFDYGSEPQQEALNLSKWQTFTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNS5</accession>
    <name>A0AAV6TNS5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001895">
        <property type="protein sequence ID" value="KAG8173298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNS5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="104" mass="11978" checksum="F22F7B6D45504CBC" modified="2024-11-27" version="1">MRHKPRRSVLKEFLMKFVHNVRRQIAVLTESLIQNPAIETLVTMAESQQEIIIYPKFTVAIGTRDCCIQTVSFCQMVRQMTHFHSLSVGKGTQLASNRESGSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TP09</accession>
    <name>A0AAV6TP09_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_022463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010001683">
        <property type="protein sequence ID" value="KAG8173513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TP09"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="249"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8173513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="441" mass="50413" checksum="FE8D2C60A6AFAAAC" modified="2024-11-27" version="1" fragment="single">PLVEHNDEESKQPRVWCVGSSGYTFRKSSVWKRQEHSHKVRQCLQEQTEKGEILQEGPGVGRKLYRIIRIIARGRPISSTAQRARDDVCLYDFVKCYDVVKETKSSLETYKFEFGYVKKRKRECLVSHKIYNVQQNPENYFYSLLLLFKPWRNPLKGHYETYTEAFNTCKEDLLSAVEHHDKLEEIRPAKYEVETLVSDPAQNSKYEADHEKNYKADEINKIEAAGAMVEFRDALANEKENSAVLADSMNTDQKRVFEYVTNKLTGNDGVLRHFVSGVGGTGKSFLIRVLKSWVKKNLKKEVAVCAPTGIAAFNINGLTLHRLLQLPIEHGGVQEYKSLNDDVLQILRSDLKDMVLLIIDEISMVSNISLLYIHLRLSKIFNTLLEDDGWFGKINILFFWRLTSASPCYAASTFHRIDNIGSGKVLVVPACNTHLAGPVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQ17</accession>
    <name>A0AAV6TQ17_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001512">
        <property type="protein sequence ID" value="KAG8173733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQ17"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="256" mass="28686" checksum="E2D31E1578695897" modified="2024-11-27" version="1">MATGGIEENKLENYRNNIQVISVLPSYDGESDSCQHFFGLFSELADLSKWSDQERVTIVKSRLKGNALRLMSDMSRSDLQSPVIDRLKLTRFIDALPAEYQLEVLKFAPDGFDKAVELTSKIQVALQFTKQLQVNERILNSQKPKYLSRSATIQIVNGSGVRFVSCVELTLNLGGQKLKQVFYVTKDIRENNLSGIIGCDFIRDKNVSVHLQEQFIGLSGLKIPFLGCTERVNTVVVTELPASLVNKLLDLERLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQI1</accession>
    <name>A0AAV6TQI1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001479">
        <property type="protein sequence ID" value="KAG8173814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQI1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="35453" checksum="C02C713543C9BDC2" modified="2024-11-27" version="1">MDFCDRRNIKEYYELLVEYGYDDLNVIVETLTKEEIDDVFKSAIPKAGHRAKLWLAVRKEKEEASKVNVSNQKVCAEKSEESSSVGSSAAWQKESLGWVPFPRKPISIFFNAVLKEMHGCIWDDLPYEDSFRKVFNSEKVRQYSYEKKLASIETKLNFITSDNMAAAGTLLDNEPMPYSGSNIKRNIGSLVELQSRVDAIKIEVIEHDTSIMLGNGGPRLPYLRFHHRNNNQTLARLNELLDKIEAVIKQLQKCEERKRKMTKWEMEGIKIQDTGRDSGSDIKRLSQKNRVLYIVWTMMRFGGEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRB5</accession>
    <name>A0AAV6TRB5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_029300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010001226">
        <property type="protein sequence ID" value="KAG8174412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRB5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000006">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="88"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8174412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="489" mass="55284" checksum="1F1A5948C3E36BE2" modified="2024-11-27" version="1">MCLACQSKTALSPHQNHSSVGVLFGPSKFDKILAAFPELTNPSHIPNGRPDTKVLHYIETKGPPVFSKAHRLSPELFEVARQEFEFLMAQGIIRPSKSAWASPLHMVKKPNGEWRPCGDHRRLNAITIPDRYPLPHIHDCTQIFHGKTVFSTLDLARAYHQIPVNHEDIEKTAVITPFRLFEFVFTPFGLRNAGQTCQRYMHQVLSGLDFCIPYLDDILIASSNESEHEDHLKQVLDCLRQHSLKLNPSKCNLGKPSVAFLGCLITSTDTLSRVTAVQKHDIDFSTMAEEQNADPELAELLANPESSLKLQHLETGKNQKLYCDVSTGSLRPYVPKKLRRSVFEHLHNLSHPGIKASRKLIQQRYVWPGMMADISTWARSCVECQRSKIHCHTHSPSQRFTLTSRRFEHIHLDIGGPLPPAVIGLDRLKPAFTDQENVGQQFSESAKPVHQESQLIPTEQAKTGNEHNCPKLPITTRSGRTVRFNPRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TT93</accession>
    <name>A0AAV6TT93_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_019085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001077">
        <property type="protein sequence ID" value="KAG8175090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TT93"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF7">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8175090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="262" mass="29584" checksum="3748234A75DAC386" modified="2024-11-27" version="1">MLGTEQGALLSCNRKFKDPREVVSACYPSSTGPVLAIERNTFFPKLFASCSTWDVKVWSEDLAVSPMFNLLSKDGYVTDVAWSNTNAPFLFVTKTTGCLELWDVLVKNQDPILSFKLESDGLVCVHPKQQCEQIACGTGNGCIHLLEVPKYTSFSNKHEKNLLSSMIDREGKREKLLEGMTREQRARERINKEKNNVSASMESTVMYSVDEVEENENGNIKEFDSNLNSELNDEEVDDTVEEVPFFDLLFVDTLKSILKNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTW9</accession>
    <name>A0AAV6TTW9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_009146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFB5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000994">
        <property type="protein sequence ID" value="KAG8175512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTW9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1220:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8175512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="8293" checksum="733B2701D54F5A43" modified="2024-11-27" version="1">MVYVMKGILVECDPSMKQFLLHLDETNAFKKKFIIEDLDETHLFIAADMLEVLQTRIDDLMDMISFPLAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUG7</accession>
    <name>A0AAV6TUG7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000983">
        <property type="protein sequence ID" value="KAG8175570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUG7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="180" mass="19730" checksum="315016E63AFB9BC9" modified="2024-11-27" version="1">MGTDRHENYTISLGFSRANRGAPDTARDAVLLREQRPYLRTSRFQGHELLQRKDNSSPGLPSTSPSSVALPHLVPKDLSPCPGWGILTPFPFGRQRDKHEHVFAFRQTSRFGTDFSDPLGQTDPCSCDPFNCCSHGTLLQLQSSRFSLEHLLLPPRSAPVAGSRPAPSTHATATLLLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUK0</accession>
    <name>A0AAV6TUK0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001060">
        <property type="protein sequence ID" value="KAG8175141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUK0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="101" mass="11094" checksum="797801A75CEAC4F4" modified="2024-11-27" version="1">MINSGLIQVTTVVSIEHHSLGISHINQNGGRKFARKACNSRGRNPATLSDTVRALCSKMERIQHYNPTHRVPNTEAAKQKAECSSKPAAHGYRTASKIPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUP1</accession>
    <name>A0AAV6TUP1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich and transmembrane domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000958">
        <property type="protein sequence ID" value="KAG8175717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUP1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13592" checksum="26BC6B547CC4FFB5" modified="2024-11-27" version="1">MAYPPQPTYSAYDQQPPQPCCGYPPNPQQPYYPQPPQPGSHQQPGCQPQPDMPPTVAQPTGGSYYPGQPPTQTIFCPVHARQAEDGLDHLCLLWCGLLTCCCWCPLVCPCMFCSKLMSTSSTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUV5</accession>
    <name>A0AAV6TUV5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001009">
        <property type="protein sequence ID" value="KAG8175406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUV5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10140" checksum="D7A6E7269F3C9315" modified="2024-11-27" version="1">MNSVERPEKRSWISWEKGSVDGSMRHRAEGVGKVDLRHAELLAVHLVPANLPGDEEVVLGGSIEGQEHGDESKLSLVKQNSVVRIQSQLFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVN2</accession>
    <name>A0AAV6TVN2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000958">
        <property type="protein sequence ID" value="KAG8175713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVN2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031793">
        <property type="entry name" value="KICSTOR_ITFG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16317">
        <property type="entry name" value="INTEGRIN ALPHA REPEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16317:SF1">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN ITFG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15907">
        <property type="entry name" value="Itfg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="204" mass="22893" checksum="EC0E9C5387C06592" modified="2024-11-27" version="1" fragment="single">NASNLTTPKHHPLASSRMRNPNISSEILGGITGTTNGIKRNTLIAVATLDGTLMLVDGDETLWSLQVDHQLFALTKLDLLGDGDEEVVACAWDGLTYMVNQQKQSVRFQFDGPVTTFTCGKYSVIPGTSVNVFVYATFQNRVYIYYDVHLPRFRIHNFLETTQSHEEINSLLPQFPIDREDSQQLKNLLQFCAYGFPLDMTGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVN8</accession>
    <name>A0AAV6TVN8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001006">
        <property type="protein sequence ID" value="KAG8175426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVN8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043596767" evidence="1">
        <location>
            <begin position="23"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="203" mass="21974" checksum="AD68E02A4E4E7F0C" modified="2024-11-27" version="1">MHLIIFFAKVTLLIILRQEVNAAKGDNSCKLPAPVESFSASLYTALTVSTDPKITNSLELKGGEGALKFYTVLKKVLEGFGVCNAEMAAFTGARPIASGETLTLQDYFSKKSVTFGGVLYHNGLLGCGNSVSMSLDLFAHIRKVLKSLDQSKIESQLQGVMQGVVQFYMDLGLDLEDVTQQTSDEFADNFKDNNKCKAVAASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVV1</accession>
    <name>A0AAV6TVV1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000950">
        <property type="protein sequence ID" value="KAG8175758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVV1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="163" mass="18506" checksum="8FC9D41BAF867999" modified="2024-11-27" version="1">MYVDDEEVKNQVAKLEKRWDNISALPKTHETHCVRTEGVNTVRYSMTSKTDGKVFSFKKLSLDAVARPSSIIVADQNVDVIPFGKWVLVGFTSDRGSAHQFVGQIIGQTNDNITVKFLKKSGQKYIWPIKEDIADVQKTQIRKILSEPSTDSREKLYFSELPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWS8</accession>
    <name>A0AAV6TWS8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein alan shepard</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_021342</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Has a role in the perception of gravity.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000903">
        <property type="protein sequence ID" value="KAG8176239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWS8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12650">
        <property type="entry name" value="RRM1_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000383">
        <property type="entry name" value="Sex lethal, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034775">
        <property type="entry name" value="Elav_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="159"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8176239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="340" mass="38149" checksum="60249BD18DA4A6EA" modified="2024-11-27" version="1">MLQAFRHYRVVESKETINNDLRKTGIDRNRIHIYNNSIWIGSVNAQTDAEIYNCFMYLTCKEPKETGQRSKIADLAELVGPRLRNFAFELFFKKDPNAVNIYEFFESEEAKMCNYDEEEYALFAKNIQKAVKFYFVTDLMNGMEGGGQQNGGGCEDSKTNLIVNYLPQTMTQEEIRSLFSSIGEVESCKLIRDKVTAGQSLGYGFVNYVRAEDAEKAISTLNGLRLQNITIKLLCGVASLRVCWQVSYARPSSEAIKGANLYVSGPPRPSPNRTSRLSSPPSGASSPPEFCVITSQVIVADFCNSDDPDNVECKRDDDALDQLAFLLIKARSEGKCVKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXM9</accession>
    <name>A0AAV6TXM9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000862">
        <property type="protein sequence ID" value="KAG8176603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXM9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="143" mass="15860" checksum="9DB6353C0A877639" modified="2024-11-27" version="1">MGIESSIPNTSAQTTDLDLSMESNGGIRASTPNVPYPIATHQPITTDPTPAAAATAYERKKRKRTPTMSNIMEQASSILSNIQGPSGSRESSIDIQAKYWSNRLHNIKNPELFAKLRMEIEITLMRYEQEDRELSEGGFNFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYB4</accession>
    <name>A0AAV6TYB4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000889">
        <property type="protein sequence ID" value="KAG8176371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYB4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="556"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="634" mass="73252" checksum="2666A094E1F3E37A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZ60</accession>
    <name>A0AAV6TZ60_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_003408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000849">
        <property type="protein sequence ID" value="KAG8176777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZ60"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043496185" evidence="2">
        <location>
            <begin position="18"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="202" mass="23479" checksum="3D41576BED626780" modified="2024-11-27" version="1">MAHSILLLWCIASTVASQAFIPAARVRRDISDTTEPAELTTTESPTDEEKATTIEETLTTFFDAEKDLRIRARKVEEFRFLDDSFRIDEARRAARTTAEDPRIRATAEETKSTTEGVQANETESAEDTLGKSLMQNLLEIMEAEYKCRQEVTRLLTEETRRMKEILAEFDAKEETRTLAHMEEENRKYAMYLRQKERMKDFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0Y7</accession>
    <name>A0AAV6U0Y7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="6">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_002528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="6"/>
    <dbReference type="EMBL" id="JAFNEN010000788">
        <property type="protein sequence ID" value="KAG8177301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0Y7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048821">
        <property type="term" value="P:erythrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042541">
        <property type="term" value="P:hemoglobin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="182"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8177301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="580" mass="64235" checksum="6117FE815FB72787" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U296</accession>
    <name>A0AAV6U296_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 20">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="20">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">JTE90_017438</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23956"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52424"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Golgi apparatus membrane</location>
            <topology evidence="2 20">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="20"/>
    <dbReference type="EMBL" id="JAFNEN010000717">
        <property type="protein sequence ID" value="KAG8178088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U296"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23433">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000047">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000005">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF101">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 20" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 20" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 20" id="KW-0430">Lectin</keyword>
    <keyword evidence="17 20" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="21">
        <location>
            <begin position="456"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG8178088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="587" mass="66816" checksum="A740D4B6F6B1E44D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5D8</accession>
    <name>A0AAV6U5D8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exophilin 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000654">
        <property type="protein sequence ID" value="KAG8179008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5D8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024845">
        <property type="entry name" value="NHS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23039:SF9">
        <property type="entry name" value="LOW QUALITY PROTEIN: NHS-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23039">
        <property type="entry name" value="NANCE-HORAN SYNDROME PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15273">
        <property type="entry name" value="NHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="176"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1220" mass="136357" checksum="CEA76E20C997DAC2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5U8</accession>
    <name>A0AAV6U5U8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000627">
        <property type="protein sequence ID" value="KAG8179417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5U8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="121" mass="13488" checksum="7EF2C7AE372C81E4" modified="2024-11-27" version="1">MSYPESLPSQRLQKSTAKAAKSPTSDTPRHTSEVMNNSNDTKKKKDIIWARGHLNERKTGALMSLYSRFFYETADLPSAGSDLPPCNYARATRGIPPLINEGIVVMPINRRPGPLCTWLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6W8</accession>
    <name>A0AAV6U6W8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_002831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000603">
        <property type="protein sequence ID" value="KAG8179792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6W8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12402">
        <property type="entry name" value="RRM_eIF4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033107">
        <property type="entry name" value="EIF-4B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="90"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8179792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="572" mass="64195" checksum="EBCB5A583E65E88C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U876</accession>
    <name>A0AAV6U876_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_025977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM121 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000601">
        <property type="protein sequence ID" value="KAG8179810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U876"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026624">
        <property type="entry name" value="CECR6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032776">
        <property type="entry name" value="CECR6/TMEM121"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47399">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47399:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14997">
        <property type="entry name" value="CECR6_TMEM121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8179810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="348" mass="39762" checksum="6460004DB214F35A" modified="2024-11-27" version="1">MTQTESPCSCSVKLVQHVLDCLGLLLIIVLQGSILDYYLILHNGGNAAWYFWFLADFLILIAFMAAAVISYRYYQKKDRQRKNNENPVKVKKSASVMRLGSLPLVYAVWFIYSSLLTAKVILLFKLDVAQSLDADSAFGPQLLKVIIASAAVVFLLLVETHNNAEPHSDHQSYIYFLITSTVFEIFDSVTFLGILFPMQSKIILTYPLENAVLVLSCINFILPTMTLYKLSLSEFGHQPRSVGLQLLYKFLHLGLVNIPYFVIRVYLWSLYDHDVTLFLLKNILAVIITLRTLVPDLKFWWSSFQQSRRKRHTFFKGAMELGAVYEITDNVGDENILPEEKKVHSTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8R0</accession>
    <name>A0AAV6U8R0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_016352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000593">
        <property type="protein sequence ID" value="KAG8179979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1291"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1431"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1604"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1706"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1465"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1564"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1635"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1223"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1307"/>
            <end position="1321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8179979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1729" mass="193505" checksum="EFA333B635D9711A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAI1</accession>
    <name>A0AAV6UAI1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_017322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000507">
        <property type="protein sequence ID" value="KAG8181572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAI1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF9">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043338907" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="26"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8181572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="188" mass="21213" checksum="45ED9B3BDDD7057C" modified="2024-11-27" version="1">MVNSRKMVPLVSFLAALRILTEAQSCNNGVGKLMFERVADYKLSGNGNSNFGGTRRAEVITRKDLPIRVLSECIRRCAEDRTTTQHVPQCRSFDFMPGKRLSPVPNHEGNDVLSSSRNSVVAEYEDSTCYLYYDQASPDGMETLVRQHDVWHFNEVCITCEFKIVFFCGVVYVVVGLSVNCYICILHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCA5</accession>
    <name>A0AAV6UCA5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000484">
        <property type="protein sequence ID" value="KAG8182002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCA5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="9611" checksum="624607A395A43544" modified="2024-11-27" version="1">MNQSTCYIKKQVRSTSQPPQKIPYRSNEAFYRLHTPDWTSNKRRTPYRNNDPKNEYHSYNNPLKEMKENRLFYFIDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCR7</accession>
    <name>A0AAV6UCR7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_015285</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000504">
        <property type="protein sequence ID" value="KAG8181643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCR7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8181643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="506" mass="57860" checksum="766D138A9B8FADBB" modified="2024-11-27" version="1">MRRRVLKSLVKAGVVLICVSGYFYQTLEFLLLYLTYPTVVDIQVSIPSEIEMPAISICSTNGVNPAKLCELGDYCLTGDSLDPSAVCEGFPAICVAENALSHFTAVNYDKFFRENNIKNGTSEFLKMPLKDYLECKIISGVSERPCDLDNVLLGSYYGTDQTPNFCYTLFSHWKNPKAEVQKVKKSETINLRAQFDCTFKIETVSEPPVPPLHQFNCMSFPAVQLSLHSRHRVDSPFVKGVNLEAGRKYRVTIKQDEKHLLPPPYQTNCTEYMPDWVARGGVGPLSQVMVVEECKLNASLQKLGCVPFSVNYPHNETICKYCQDCPEAKLIEQECAQLLSYYNQPCDSIDYIMNAEEVVINIEKIFSSVFTKFDEVVIVKTMGYDCSDNKRYNRECQSVEIDIDFDEFEITNISYIPKFETLEMFSVIGGYTGMYLGISIVAIYDFAESLMTFLVSYVRKSRRRRNKQRANRSAKDVWRQQGWDGYQYPSAGVRKRSMQYQPRDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDS8</accession>
    <name>A0AAV6UDS8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000502">
        <property type="protein sequence ID" value="KAG8181670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDS8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="108" mass="12092" checksum="D7E7B8F86079C92C" modified="2024-11-27" version="1">MGHYTYCIGIIYKIQGLPHFPCQYFQLRKKHKVAIKCTAGITTTCLPGRKLLFQHIKSTPSIGRFYLSPGIQLFETQPVAKQLGQVLTILLNISSANAHICDELVCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UE45</accession>
    <name>A0AAV6UE45_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bursicon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Bursicon subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_004720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of burs and pburs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000472">
        <property type="protein sequence ID" value="KAG8182264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UE45"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038098">
        <property type="term" value="P:sequestering of BMP from receptor via BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283:SF7">
        <property type="entry name" value="BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283">
        <property type="entry name" value="GREMLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043989329" description="Bursicon" evidence="10">
        <location>
            <begin position="25"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="11">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="43"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8182264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="165" mass="18141" checksum="7B37EDE0F6F19CEF" modified="2024-11-27" version="1">MSLASLSVVACCLLQATLWSLSEGRGEVCHLRPVIHVLQQPGCIPKPIPSFACQGSCSSYVQVSGSKFWQVERSCMCCQEMGEREASIGIFCPKASPRFRKIVTRAPVECMCRPCTAVDEASVHPQEFSPMLTAPKELLLKDMPQSPEAYHIRGEFGPDKEIPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEF9</accession>
    <name>A0AAV6UEF9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_017726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000505">
        <property type="protein sequence ID" value="KAG8181606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEF9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051963">
        <property type="entry name" value="Adhesion_GPCR_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930:SF4">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043686576" evidence="5">
        <location>
            <begin position="21"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8181606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="313" mass="35659" checksum="5CC3C7A5576FAFAA" modified="2024-11-27" version="1">MALLLPIFLVFVGLVISGKGAPITCPSTEDLRPCTCQRVSYGLEVMCAKFNTSSHLLRAFRILRDYNVNTILLHGLYINEVLPADLFDGMKVSAIRVEKSKLMFSRPAFSGLDPWLHVLNVAQDSFVRSEERFSLAKLTKLNELIVQKIHLDRVEDKWLNEKVPNVHKVDLDFNDIGLLEDHAFANLQSLTFISVAENRIKVIKRSMFPNPALKLTRIDLSYNEISYLPEDFFVGMPSLKEIIFPGNDLKSLHEATWTPVWEQLSQIILSENSIDCDNSIKWIKKYREPRQLAGTCVLPKSLTGHNIKDLYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEN2</accession>
    <name>A0AAV6UEN2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_014827</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000500">
        <property type="protein sequence ID" value="KAG8181696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEN2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="15">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8181696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="277" mass="31029" checksum="AEF5552AEE9935BE" modified="2024-11-27" version="1">MKHYLRNIYCHCCVSKLCAIINFPKDPERRKEWESKVKKPNFKATDNSKICSKHFTPDCFEQGKFGGTWLTADAVPTIFEWEQPKSAKLPTLAVVPKSSAKVLAVAVVPRGSARVAVMPQRSATVLAVSVVPQGNNKMPAVEVLPQSNAKMLAMTVVPKSSAKVPAATVVSESSENKLPQKRKNSDVESSAPNISPTTFENKKRLCYFGDFNENTVIDPENARKFFHLAKSEVVSKNKEIRSLRKEQKRLKKRVAKLIKMLYEFRERHIIAGDVSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGX7</accession>
    <name>A0AAV6UGX7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_017097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000436">
        <property type="protein sequence ID" value="KAG8183009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGX7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF24">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 3, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="97"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8183009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="426" mass="49153" checksum="0A5E5AD4161399A7" modified="2024-11-27" version="1">MSISVLLFKIFRVVGLFFLAAHMTIVFLFSGLLFNLLQLILYKTLYNTNRTLYRKLNYYLIYWSWSQILAIYEWRSNSACTVYGDPESVHSFGKEHCIVLMNHKYDIDWVISWFMANHLRMLGNAKASAKKALRNIPVIGWGWIFGEMIFLDRNWAKDKLTLGDKLDKLASYEDPIMLLYFCEGTRFTKEKHKASMEFAKARNLPLLEHHLCPRTSGFNFTAKHLKGKVPAVFNIQLGFPNSEKKPTFSNLLRGYSFNADLFFERIPLDDVPTESDEATSKWLHELYQKKDKLMDDYYKNQKFPGEGTKVGRSYRSLFNSLFWNIFIGVPWAYLIFKVLTTGNMFLVSIVTTVFVMLFTVMFYMLRATKADKGSSYGTDKKSPAKVKNGATKEDNAVNDTAETTKGGVESAEEKILQNKEATNNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGY3</accession>
    <name>A0AAV6UGY3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000460">
        <property type="protein sequence ID" value="KAG8182536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGY3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7744" checksum="1DF22554A4BC147C" modified="2024-11-27" version="1">MEATSMLVDFMEAKSMLVDCMEAALPLERTFMEASMVEMYMELTRSTEELLILEYSFQAVAKCQLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI40</accession>
    <name>A0AAV6UI40_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase p58-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000401">
        <property type="protein sequence ID" value="KAG8183850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UI40"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase p58-like C-terminal" evidence="1">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="10388" checksum="6C9B4A5BB4B695B9" modified="2024-11-27" version="1">MKRCQELAISKMEECQQKNKTWYDKKAVKREFQIGDLVLIFATFKSNKLIPHWTSPGTILRKLSETNYVVQLPGEKATSKVYHVNMLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJL2</accession>
    <name>A0AAV6UJL2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000402">
        <property type="protein sequence ID" value="KAG8183821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJL2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.740">
        <property type="entry name" value="Crisp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042076">
        <property type="entry name" value="Crisp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013871">
        <property type="entry name" value="Cysteine_rich_secretory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08562">
        <property type="entry name" value="Crisp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57546">
        <property type="entry name" value="Crisp domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="42"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="261" mass="30084" checksum="20CD2F1D4EEFBA11" modified="2024-11-27" version="1">MKILIGAIILVSYIFFGSSKLSRPKLYGNAIPYDQLDPTTNGTKRKILLAHNYFRSIVDPPAADMLELSWHEEAASDAQRWSEACQLLLHDNVTGRWTDDFGSCGQNIFVANVQVPWFFAIKVWFMERQNFTYGEDLNNANVVGHYTQMVWYSTHKVGCGFNYCPVNNITKFPYFSYVCNYCPIGNYPERFDRPYTNGTACSECEGYCKFNKLCTNGCPYADFWTNCDVFNSTHHSWLCDDENTERFQSCRSTCRCNGKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJP8</accession>
    <name>A0AAV6UJP8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Histone-lysine N-methyltransferase PRDM9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_029336</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000407">
        <property type="protein sequence ID" value="KAG8183755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJP8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19193">
        <property type="entry name" value="PR-SET_PRDM7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044417">
        <property type="entry name" value="PRDM7_9_PR-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="15">
        <location>
            <begin position="206"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8183755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="77515" checksum="B742DEA424D0E4EF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKE7</accession>
    <name>A0AAV6UKE7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_017774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000354">
        <property type="protein sequence ID" value="KAG8184920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKE7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652:SF67">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8184920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39700" checksum="172E5298CD034DEA" modified="2024-11-27" version="1">MCFLQEISAHYRKEYLEDYPESKTKDVELGLYSESVVSLRCSRQKGKSNQTKGNNNVILSANENSGIVISVQSVKFDNSCNTGESIKFQSTDKMFMVCDRYFDPKIDVDGMVFKSNNVTVSYLNKQTITPYCKFTVTAFTTPPCSMNNNFRCSNGICIWKNLICDYKNNCGDNSDEAYDVCRQEHVSGHMFLYYIFVPPMLITILILLCCCLQGSIILPPRYGPDEVFYLYNRGYQAYPLASTPDYTQAPQNLQRMIDYNTNQRLPNQNEPSTSKQASEEQDNEQQNSNQNKETKSNKEPRTSSQQNSTMSTRNSEKRSKEEQESSERNRNSNKETSKNISETNKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKJ4</accession>
    <name>A0AAV6UKJ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_013200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000382">
        <property type="protein sequence ID" value="KAG8184223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKJ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048370">
        <property type="entry name" value="ZSWIM4-8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619:SF0">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21055">
        <property type="entry name" value="ZSWIM4-8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8184223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1071" mass="119718" checksum="77569DCD74EBF298" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULH8</accession>
    <name>A0AAV6ULH8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000372">
        <property type="protein sequence ID" value="KAG8184481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULH8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="183" mass="19850" checksum="417C693B87C5E1FF" modified="2024-11-27" version="1">MESETNPDSSRSPSPCSEDKTSEEISTKLLRAVHLKHPKTDLPTTESSKRQTPELISTFSVASLLAGTKSHSPRPTLWSPSDFYMPDPHHRLESSLSPGLKSPDICVPVSEMYLMDRILDGSHPGYLGPHHARIPHPLPGVWASGRAHLAGQRPMGPPPTSAGQWAAAISLQAANPPGKMRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMH7</accession>
    <name>A0AAV6UMH7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="7">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_004923</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000359">
        <property type="protein sequence ID" value="KAG8184825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010000359">
        <property type="protein sequence ID" value="KAG8184826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMH7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000116">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000237">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8184826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="305" mass="33840" checksum="193296FBE2C42B0C" modified="2024-11-27" version="1">MADQNGAANSNLEMTVIEALKDHPKGVTQKDLEALIPSLSVVELVQVLNKFISQDKINLMRKGKQLVYVIKDGSSGKKPLAGTDVEDKVIYEAVKRAGNDGISSKELKYACNLPQPQITKILKSMEAKRLVKSVVSASKKKVFMLFGLEPSHAVTGGTFYSGQEFESEFVDVLGDQCYRYLQQAKALAEKHSDPLSQRRAAFKSSKEICDYINSLKISKVELKMSDIENILESLVYDAKVEKSVSMSNTFKDTGSENFYRIVKPLLLNAGLMRMPCGVCPVFKDCGAGRDISPSTCIYMKEWLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UN12</accession>
    <name>A0AAV6UN12_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000349">
        <property type="protein sequence ID" value="KAG8185021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UN12"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11033" checksum="A9AFEA4D028FCBD5" modified="2024-11-27" version="1">MSQYGMDSLLLYFGGRRLVQAHFLPKQHSSTKHTPLFNQFPTTRTNANDSVVGNHPSMKVGLLIIPTANIHQTPSWGSLGGVYCLCSYKNTQTRILGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNF3</accession>
    <name>A0AAV6UNF3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_014580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000347">
        <property type="protein sequence ID" value="KAG8185105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNF3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="6">
        <location>
            <begin position="514"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="913"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8185105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1264" mass="143848" checksum="327C63F8477C3FC4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNJ5</accession>
    <name>A0AAV6UNJ5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_005129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000344">
        <property type="protein sequence ID" value="KAG8185150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNJ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="LDL-receptor class B" evidence="2">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="361"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8185150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="398" mass="44203" checksum="E38B3CB7F3174190" modified="2024-11-27" version="1">MSILLLQNCFDSPHAVQFFLTFFIHHLQTTSSLRSRFTMNRLLLQNLGDSPVLIHLLDSPSTDFFHCMLNHCTASSLCVSFFTLSCLVTADDQDGSASLLYCDDDIRNFSLASGTDSLLMSGIKRPLVVDYHMKSKVFFWIDSNSNINKAPLWQEGARPSVLRRGVISYGLAVDWIHNLIYWTDHSIGVSRLDGSMARTVLKEEGTNPQAIVLNPAEGFMFCLAIDLDIQSIFWVDYTLNYLHSCKFDGNHRKVLIAKITNPTSIDIYGQHVYFVTQGKGYEALHKLSKVDGSGWTKVFDGKRSLRSLKIFDPSKQLEGYDVCGDDNGGCSHLCLPTSGHTFSCACPNDLNMSSDNHTCLNSDGSPATTPSSTTNAPPSQLPFTVFQTNFPSNTGNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPQ3</accession>
    <name>A0AAV6UPQ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000302">
        <property type="protein sequence ID" value="KAG8186420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPQ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="171" mass="18933" checksum="1B0F39541F0FE0D6" modified="2024-11-27" version="1">MMMNSYFEQGGFYNGGPTATETQNPYRFPQSLLVPPYGQNPGSAAPRNAHESSAPYGGGDPNSCKMYNSSDSTFKAECLVKEQNGFSQAVVKEMVNSWPAAMARASEQMRSFATENSAAPRGTEWQQCCQTSPPIGQTHSNTFYPWMAVQGLYSIVTFHNSHLLHSNFYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQR5</accession>
    <name>A0AAV6UQR5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_003536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000318">
        <property type="protein sequence ID" value="KAG8185978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF502">
        <property type="entry name" value="BETA-2-GLYCOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="348"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="464"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="645"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="762"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="879"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="996"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1171"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1344"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1675"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="350"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="647"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="764"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1027"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1202"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1383"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1711"/>
            <end position="1738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8185978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2212" mass="245383" checksum="EE15D50C1AEE739D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UR28</accession>
    <name>A0AAV6UR28_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000284">
        <property type="protein sequence ID" value="KAG8186922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UR28"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7665" checksum="7FFB39FC94E830B2" modified="2024-11-27" version="1">MGARTVVKPSKYQKKDTSRPLWDPDNDFAQRFECLGRLLAIVKAYGKSPFSCDNSGILYTKIKLGQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URD0</accession>
    <name>A0AAV6URD0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000311">
        <property type="protein sequence ID" value="KAG8186161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URD0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="29794" checksum="851DBE1BD9B2B5FC" modified="2024-11-27" version="1">MIALLLLFAFYCFLLVFVEFFGLDVFDLWDICLLMFWHRTFQLMNTRCWKHRLILLVIKFLYAEILVGLFIIKQLYYLIKMMWTGFLSPILYVVLLSKIMKLFRQFKRYLKEQWSSIVDILDELEVLIYNFLMQVWWNMEEYLPEPWMDLLEYLLEVLTELLYFIWQLVTFLPFFLIYQILLFYNLFVDFCGRKRPREDEACFVVDDEIQVFTSRGEIRFGMEEAKDLSRTRRMYWLFYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URL0</accession>
    <name>A0AAV6URL0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_004856</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000278">
        <property type="protein sequence ID" value="KAG8187110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URL0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF284">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="86"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8187110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="316" mass="35990" checksum="35189980264F775D" modified="2024-11-27" version="1">MRQCITPHERLAATLRFLATGMNFEELKFVTAISPQRLGVIIPETCLAILKNLRAYMMIPRTQEDWKAVAQEFEDKWNFPNCVGAVDGKHIRITPPCGSGSTFWNYKHFHSIVLMAIASANYEFICCEVGTNGRISDGGAIKTTEFYGDLISGNLNLPPPEPINGSLLAFPYVFLGDEAFALRPDFMKPFNVKSLNARRRIYNYRLSRARRTVENAFGILSNRFRILHTSINLDLRKIEIVVLTCCILHNFLRRNCASYISEEDVSDNSNNERMLTPLENNNGGNISNQAKLVREMYVDYFNEEGAVEWQNERVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USF7</accession>
    <name>A0AAV6USF7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000281">
        <property type="protein sequence ID" value="KAG8187039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USF7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20229" checksum="88325DBA4319A922" modified="2024-11-27" version="1">MRVRGGAHYSRADSEHSIIVATDTGEEEESADFYWCFVSSLRVDVFAFLAANKFKRPFSPHTRQTYRKKKPFSQRSEEEISGFASLFARIVVVVSLLRFFRVELFPFSGDLQPMSDFTVAGDDRSMFLFLYKIKERISGARRTAPFLTFCKSQLYSLTCGNTPYLDFTSPPRILLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USM8</accession>
    <name>A0AAV6USM8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000288">
        <property type="protein sequence ID" value="KAG8186812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USM8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000855">
        <property type="entry name" value="Peptidase_C5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00770">
        <property type="entry name" value="Peptidase_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="21419" checksum="8B8A6C63357E7006" modified="2024-11-27" version="1">MKIYFRGVKTANELIDVFNVIKNELCWWFVSKTTPKKSRKNTQEIGHWVAFFYNNKVLDFFDPAGQSIEDQKKEIKDFLQNFQISSTVSEVNCVVQEGTMQSPNSIYCGEYCIFFMKHLTLGLSPRFICKFLRSHQDGKERDDHVVHEVETLNSASLEIYNEHRSNIPYFLEKIEEMKSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTQ9</accession>
    <name>A0AAV6UTQ9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gamma-tubulin complex component 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_005739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000282">
        <property type="protein sequence ID" value="KAG8186965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTQ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="305"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="811"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8186965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1155" mass="132654" checksum="2AED8B0636A7728C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTV3</accession>
    <name>A0AAV6UTV3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Spectrin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_005779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spectrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000282">
        <property type="protein sequence ID" value="KAG8187010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTV3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045169">
        <property type="term" value="C:fusome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045170">
        <property type="term" value="C:spectrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042062">
        <property type="term" value="P:long-term strengthening of neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048790">
        <property type="term" value="P:maintenance of presynaptic active zone structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000006">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000013">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000020">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0117">Actin capping</keyword>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8187010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="80998" checksum="B904304DA3FE209E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUA1</accession>
    <name>A0AAV6UUA1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000278">
        <property type="protein sequence ID" value="KAG8187100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUA1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10211" checksum="E1C19C353ED6CDEF" modified="2024-11-27" version="1">MKKSKKKLKVNISPPSSSQEIENSDSGDILSVGITSDTEDEYKDSDLVDVILDIGTSESEIESDSSSDSDVASIFTRTRTGRTASTWKIKKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UV37</accession>
    <name>A0AAV6UV37_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_005519</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000264">
        <property type="protein sequence ID" value="KAG8187667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UV37"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21376">
        <property type="entry name" value="cwf21_SRRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047489">
        <property type="entry name" value="SRRM3_cwf21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="7">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8187667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="265" mass="29681" checksum="33FE4CF701D0C1C6" modified="2024-11-27" version="1">MYNGIGLVTPRGSGTNGYVQRNMAFVQKSKEKVSYKTEEDIKRLDAMSNRKPNQGILAHERKRTIELKCLEMQELMEDEGYPEDEIETKVAMFRQMLVDKEGAGEKEIPKDEFGRPLQQSAYVTTSAAGRYKRILSPLPPLGGGENRKVCGRGLPRGVYGIDLPRVPSMGRRACCCCGILFREMRGSFSTVWWSPLLPDAALANGALVGGAYILQAQCVLAYTQVRRSWSLRYDAYFGWPRGGTMSWSDLKGIRSKVCKKAQHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVV3</accession>
    <name>A0AAV6UVV3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000254">
        <property type="protein sequence ID" value="KAG8187944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVV3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="85" mass="9672" checksum="33E6B601B137519B" modified="2024-11-27" version="1">MVTHISQADPEVPIADTEPRKSDHREHGWETGQGYVRNTTLPFHFGIRSQTECQSTYHPIPNCSPSHHQIAQQKIVSFCCIENSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXN5</accession>
    <name>A0AAV6UXN5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXN5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="694" mass="79045" checksum="FB86D429BF3F6679" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UY80</accession>
    <name>A0AAV6UY80_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Nicotinic acetylcholine receptor alpha 1 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">JTE90_009186</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000230">
        <property type="protein sequence ID" value="KAG8188793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UY80"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19031">
        <property type="entry name" value="LGIC_ECD_nAChR_proto_alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000013">
        <property type="entry name" value="Acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000012">
        <property type="entry name" value="Acetylcholine receptor subunit alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000022">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit alpha4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043097271" description="Nicotinic acetylcholine receptor alpha 1 subunit" evidence="18">
        <location>
            <begin position="22"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="20">
        <location>
            <begin position="26"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="21">
        <location>
            <begin position="247"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG8188793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="59378" checksum="91944F3C6EA8C4DA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYZ9</accession>
    <name>A0AAV6UYZ9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_018283</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000228">
        <property type="protein sequence ID" value="KAG8188878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000298">
        <property type="entry name" value="ATP-binding cassette sub-family A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000327">
        <property type="entry name" value="ATP-binding cassette sub-family A member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1076"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1117"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1158"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1192"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="506"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1379"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="826"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8188878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1725" mass="194006" checksum="CAD0450EC8C51848" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZC9</accession>
    <name>A0AAV6UZC9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000207">
        <property type="protein sequence ID" value="KAG8189696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZC9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8383" checksum="D997889984C49843" modified="2024-11-27" version="1">MKDRFTTSSDVTLQPPRYNQHGKKSYNASISSKHSQRLKKNIGKRAKSDAFAELSAANASTGNQFIGRKWTRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZD7</accession>
    <name>A0AAV6UZD7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000202">
        <property type="protein sequence ID" value="KAG8189822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZD7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="8126" checksum="987702073FCAA2E7" modified="2024-11-27" version="1">MSIPEARFEPTNFGNQDQSSRPSLGLMDWESVRNSVTPISCYKRFQEGRLLTSENRQVKVNIPYMVNDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V092</accession>
    <name>A0AAV6V092_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_021890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000217">
        <property type="protein sequence ID" value="KAG8189388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V092"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15669">
        <property type="entry name" value="ePHD_PHF7_G2E3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051188">
        <property type="entry name" value="PHD-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059102">
        <property type="entry name" value="PHD_PHF7/G2E3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042013">
        <property type="entry name" value="PHF7/G2E3_ePHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420:SF42">
        <property type="entry name" value="G2_M PHASE-SPECIFIC E3 UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26054">
        <property type="entry name" value="PHD_G2E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="41"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="171"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8189388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="670" mass="75273" checksum="F84A753173A76197" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V294</accession>
    <name>A0AAV6V294_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylyl cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000179">
        <property type="protein sequence ID" value="KAG8190624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V294"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018616">
        <property type="entry name" value="GUCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400">
        <property type="entry name" value="GUANYLYL CYCLASE DOMAIN CONTAINING PROTEIN 1 GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400:SF1">
        <property type="entry name" value="PROTEIN GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09778">
        <property type="entry name" value="Guanylate_cyc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23987" checksum="178D77DBD0B49B66" modified="2024-11-27" version="1">MGGGARDLNSIEIPLVHVKQHLSWDCGISAVMMVLSDKDRLYMKENLDEVSIKEGFDKSTWTIDLAYLLHKFGDFYLRVLSKDAQRINDRFETADSNGVKVEKRSVGMDEIVDHLGSGNPAIVLVNANLLFCDTCTCHAKKCLMQVLGCCNSSFSYQGHYIVLCGFNKRDKKVFYRNPSVFDKVCTIPYDSFEVARKSFGTDEDVLFVYFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2P4</accession>
    <name>A0AAV6V2P4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000178">
        <property type="protein sequence ID" value="KAG8190642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2P4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="218" mass="23439" checksum="06122926DCE1D1FF" modified="2024-11-27" version="1">MKLCVVRGEEIVPYLSVYPRRGELRLGHHHADPEDGHDERVVADPPPLLEERLPPPEPVPDAGPRGRRGAPASPPAAGPRRPRGRTALDLLRRGQVDRARSHIFEAADGAVHADGRPRPGASGHPRPTEGGPHEARGHPYRRRGGIGVTSPADGLFVFDGALMVRMRRRTTDEGIFVASAGGGIPSSVWVGGCWDWETGVCWKGAKPSGMVAKNIDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V499</accession>
    <name>A0AAV6V499_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase assembly protein COX19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_006077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the COX19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V499"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8191329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="10295" checksum="B06224371CD7A09C" modified="2024-11-27" version="1">MSSLTFQQKPFFPSPPDKGSFPLDHEGECKKQMLQYLLCMNRKENQNSECRLLAKDYLGCRMDKNLMAREDWPSLGFNEKVEESTKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4U3</accession>
    <name>A0AAV6V4U3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_024869</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000175">
        <property type="protein sequence ID" value="KAG8190736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4U3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000100">
        <property type="entry name" value="Cyclic nucleotide-gated cation channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF4">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="497"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8190736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="529" mass="60559" checksum="0051DCB96F879740" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V673</accession>
    <name>A0AAV6V673_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000157">
        <property type="protein sequence ID" value="KAG8191573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V673"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="188" mass="20746" checksum="8CAFF2550254E6A8" modified="2024-11-27" version="1">MKSSNVTVTSFVEELCLKVYNFFFKGTSANPDCSIPPLSENRDGTAVMDITCCYDVSFPASSEQSANMPDDANMPDESFRDTSTPLPTPTPSSSSASQPRIIAARRILKKCKRNANASVRAADSMAAAAKARQEAFQKETSGQLKLQQLQMEHAQQEHEARMAAINAERLSHKAKKMYYEAKLVKLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAL1</accession>
    <name>A0AAV6VAL1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_025607</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000133">
        <property type="protein sequence ID" value="KAG8192898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAL1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF73">
        <property type="entry name" value="SODIUM_CALCIUM EXCHANGER MEMBRANE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="763"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="61"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8192898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="793" mass="89227" checksum="69AA6EDE339BB79A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBG7</accession>
    <name>A0AAV6VBG7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_009629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000122">
        <property type="protein sequence ID" value="KAG8193403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBG7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026521">
        <property type="entry name" value="THAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47696">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47696:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8193403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8739" checksum="85BD017AA8DC5E5F" modified="2024-11-27" version="1">MSCVAFGCYNNSSKKIAGITFHRFPKEEILRKEWAKAVKRDNWNPSKHSFFVQRDFAEGEVVPGVKHDNPNPFLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBU2</accession>
    <name>A0AAV6VBU2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cullin-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_003734</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000119">
        <property type="protein sequence ID" value="KAG8193523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBU2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000142">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000009">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000014">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000017">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000004">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="12">
        <location>
            <begin position="403"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8193523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="778" mass="90674" checksum="FDAA183DA2A1A425" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCZ0</accession>
    <name>A0AAV6VCZ0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCZ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="10855" checksum="3A7F3E9542AC7A39" modified="2024-11-27" version="1">MINPPQSDQNSFLAPLTHHLQFDVTDPPFSFPLPGREPIGWCFRDFPTLSPPTSCRMRRKSVPNGSVGKVERNYFFSVHLNHEKATPEKMKFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VE81</accession>
    <name>A0AAV6VE81_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000104">
        <property type="protein sequence ID" value="KAG8194363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VE81"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="338" mass="35050" checksum="680860E013DB58C3" modified="2024-11-27" version="1">MYPGLRYTRLLYPILLFPRRLFPRLLSPRRLPETTVPETTVPETTVPDTTVPETTVPDTTVPETTVPGTTEPETTVADTIVADTIVADTIVADTIVPDTTVPGTTVPGTTVPGTTVPGTTTTAPETTEPETSVTETTVPETTVPETTVPETTVPGTTVPETNAPETTEPETTVPETTVSDTTVPDTTVTDTTVPGTTVPDTTVPGTTVPGTTVPGTTVPETTVPETTVPETTVPETTVPETTVPETTVPETTVPETTVPETTVPGTTVPGTTVPGTTVPVTTVPGTTVPGTTVPENTVPETTVPETIVPETTVPETTLPETTVPETIVLETTELASIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEM7</accession>
    <name>A0AAV6VEM7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Unconventional myosin-XV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_023338</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000092">
        <property type="protein sequence ID" value="KAG8195162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEM7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF26">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MyTH4" evidence="7">
        <location>
            <begin position="112"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="6">
        <location>
            <begin position="272"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8195162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="69884" checksum="B5EFE05CDDC4E196" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VG76</accession>
    <name>A0AAV6VG76_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SAM and SH3 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_003116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000101">
        <property type="protein sequence ID" value="KAG8194643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VG76"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051725">
        <property type="entry name" value="SAM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058666">
        <property type="entry name" value="SASH1/NUB1_homeodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301:SF11">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301">
        <property type="entry name" value="SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26285">
        <property type="entry name" value="SASH1_Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="444"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="521"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="966"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="852"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8194643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1038" mass="116006" checksum="BD16C07D62132F89" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGE8</accession>
    <name>A0AAV6VGE8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000084">
        <property type="protein sequence ID" value="KAG8195562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGE8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10619" checksum="BEBB45E37B087809" modified="2024-11-27" version="1">MARETYKNTHLIADYKKKKPRHKKDMKERVWPTHEWADGRFPFPPEQVGAPTTIHGSRHPTRTPGPTLSHTTQLLDNNSGSKSLLFAISTETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHS9</accession>
    <name>A0AAV6VHS9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000081">
        <property type="protein sequence ID" value="KAG8195673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHS9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="191" mass="21177" checksum="03466B0314F35918" modified="2024-11-27" version="1">MIMDTLSGVLSGDTGPGTFSLSFDTFKLLGSDIGDLEPPKSTFPTVDIRLVQPRIKKEDGEEGSEAEDDTLNTPVSTSADVSTFFCTDTTISDPVPITDILDSETCLTLRSCDALLQSYRMLWDSGVSSNLRTRNIKGKTFKEKKLEEWPDDFLTNREFLSGSGLVEWDRLADLWIYLNVVTRAFGAMLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VI41</accession>
    <name>A0AAV6VI41_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_023847</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the HMX homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000073">
        <property type="protein sequence ID" value="KAG8196294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VI41"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000053">
        <property type="entry name" value="H6 family homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051300">
        <property type="entry name" value="HMX_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="62"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="64"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8196294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="191" mass="20716" checksum="710BF490C2B60B20" modified="2024-11-27" version="1">MYGLCQPSSSSPPADDFLNSDSRASSPLSSGAVTDDTPAAHGGTGSASNADSDGKKSGKNNRRKKKTRTVFTRSQVFQLESTFDMKRYLSSSERAGLAASLHLTETQVKIWFQNRRNKWKRQLAAELEAANMAHAQRMVRVPILYHDTGSSSVTATENSSLSVATYPSLYYHHASFANSQSGARAPLPSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKW1</accession>
    <name>A0AAV6VKW1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_007555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKW1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051606">
        <property type="term" value="P:detection of stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421:SF29">
        <property type="entry name" value="GUSTATORY RECEPTOR 5A FOR TREHALOSE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8197309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="51870" checksum="0D0DA4F711BCA87A" modified="2024-11-27" version="1">MHHLLGLEQRVRGTPSRCRFCGRAMHRISPVLKPHQHRGSTRQGKHEGKQYSCSAVLRPVITTLRLVGVCVLPNLGCRLWAVGITVFRLMYLGSCISNMVLNNSFAFEYISVVLTTTSSLLASNLLNLSRAELRKAVDKLDYTIKQLPTGKGSLKNCFRRVIGLTLIGWFYLLLRLVAVICVVDNAPAQFQFQSIFYSKPPDYFTDIASYICVAFVSSLEVLFIQGALIFTPVLFMSVCMILSEAYSEHNRVIVNLVGPTEDLGNEFNKVRSFHEKLCSLVTYMDSIFGKIIFFWFLFLIVTVCMDITQLFTDDTLLKNKTQDDVFFFSLKVIYSVLSFLGTCATAAGVSQEAHASLPTVHALTLRTSRMDLDTKLQIQFFLNRLTSPTVGLSGWNFFTINKGFILNVSAALVTYTVVVIQMNPKAMRVIHHLVAQTVNNGTSPNTNAENNESVNNNSTNSSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLM7</accession>
    <name>A0AAV6VLM7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_007233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000054">
        <property type="protein sequence ID" value="KAG8197494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLM7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043888143" evidence="2">
        <location>
            <begin position="26"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8197494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="138" mass="15246" checksum="447D886085B00D3A" modified="2024-11-27" version="1">MEISFYVLLVLACLVLLLAMWVCSGSSTQKWGPDLTLELPPHMLQEVFFGPQKKKNNGGFNKSYPAPSAPSELPGDPLLCNEHKMGVSAPPPTRYHRPAPKPPVFVDMESAVKVLPSQFAPKHKLRPVFSTFSTEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM20</accession>
    <name>A0AAV6VM20_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_014520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000064">
        <property type="protein sequence ID" value="KAG8196788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM20"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8196788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="283" mass="32128" checksum="CA1DF75931A4A7E4" modified="2024-11-27" version="1">MDLNTSDSRGQQSLSSPDKVISPFTTPGDTSDRNFLPSTSSGCNPKLLYFTPVPVIRHTDAVAKRKLTFCVPSVNCDLTLQSNVEESSTVHLGSVTNRPLRGRPSAKDIKELHRLRAVSKFKCTECPMGFQRKKSLATHMLTHCAEKRHDCSYPECGKRFTQFSHLTTHWRVHTREKPFVCTAQNCNSRSTFKRGKCVYHPGKNLIRQDETPEKIVERLSSNQENMSETEVTWVMEHITKKQIGTATTPQEDPLDVLIGARYLMFYINNCHAKVQNEKLGMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPF1</accession>
    <name>A0AAV6VPF1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="4">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2B</fullName>
            <shortName evidence="4">MOCS2B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_001639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + cyclic pyranopterin phosphate + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MoaE family. MOCS2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPF1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.40:FF:000002">
        <property type="entry name" value="Molybdopterin synthase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03052">
        <property type="entry name" value="MOC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028888">
        <property type="entry name" value="MOCS2B_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8197717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="151" mass="16919" checksum="159CC89A04FCF73D" modified="2024-11-27" version="1">MDCIKITTDKINIPEALSLLSHPSCGATATFMGTTRDNFEGKKVKQLSYEAYGSMAVKELHKISDSMKTRWKVKNVVLIHRIGTVPVCETSVLVAASSPHRKDALEAVSYGIDVIKAEVPIWKKEEYEDGTYEWKENCECSKKFGDVCDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPJ8</accession>
    <name>A0AAV6VPJ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hypoxia-inducible factor 1 alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_017379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000039">
        <property type="protein sequence ID" value="KAG8198514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPJ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF17">
        <property type="entry name" value="PROTEIN SIMILAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="453"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8198514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="66075" checksum="CAA395417E8B46C7" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VR87</accession>
    <name>A0AAV6VR87_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondria-eating protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Spermatogenesis-associated protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_021636</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIEAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VR87"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035694">
        <property type="term" value="P:mitochondrial protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035695">
        <property type="term" value="P:mitophagy by internal vacuole formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026169">
        <property type="entry name" value="MIEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771:SF1">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="15">
        <location>
            <begin position="638"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="512"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="580"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8198392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="835" mass="94261" checksum="56A124CF9FECD1E0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRH0</accession>
    <name>A0AAV6VRH0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_000332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRH0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8199467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="279" mass="31149" checksum="00B109463CEBDD00" modified="2024-11-27" version="1">MTRLYDPTSKLPKRRNHSGRHKSRDKEYLANYGAPNGYITMLFGVWRGIEMGWLHDYTGSYDPGFYTSGLMIAIGGLMLFFIPCVQSGVKKREDKHQYTVEITLSPTKSLSPVPSHGTSANPDCSIQPLSENRDGTAVMDINCCYDVSFPASSEQSENMPDDANMPDESFRDTSTSLPTPTPSSRSASQPKIIAARCILKKCKRNANASVRAAYSMAAAAKARQEAFEKETSGQLKLQQLQMQHTQQEQEARMTAINAERLSHDAKKMYYEAKLVKLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSU0</accession>
    <name>A0AAV6VSU0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSU0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8799" checksum="F6D1FE83FFF29C05" modified="2024-11-27" version="1">MFFYATTSALCNHGNPSIFSQSFKISAGDVQSTDLMSLDLLFLRGLENAQDVDAQEYSAIKSKIFFSRRNPRNDIKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT48</accession>
    <name>A0AAV6VT48_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000029">
        <property type="protein sequence ID" value="KAG8199250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT48"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="13"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="167" mass="18749" checksum="805AF4755BFA1B3F" modified="2024-11-27" version="1">MTEPTPVVAAIKIPQYNHSDPALWFQMCEATFELGTPKPVTEGKTKYNYCVAHLPPETASLVRDILLSPATDDPYKTLKEALIDRSGESGHQEILRLLQGEHIGDRRPTELLRVMKRRAAAHQVPDKLMLELFLQHLPSHVQTVLAAVTPLTLDKAALYKETCCFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTF7</accession>
    <name>A0AAV6VTF7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000035">
        <property type="protein sequence ID" value="KAG8198776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTF7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="373" mass="43427" checksum="D1A813052409D824" modified="2024-11-27" version="1">MATRSLLFFLDRSQYDVIKSCGGVQGYLPNFCLVYEEAYDFYNLHLAAVETNYHLYEKHFGANVCNTCFKVFCRVWIKSECTCNNLAYSPDWLRRESTSSLDSQIRTSERCESFGCLSVKGLRSTSFEQEIDIGACLEPSWLKPQAEKCLPVSKIENSQVFSTHAIGNNFTISTAEDCGNRNTAKEAFNLSTQNPAPPNRDNTELYQVTSESAPFPLPQDTGKCLSCQQNKNCLSYSPRKRFEKKREKFHAVEFFRERPFRDWQYFFGRRMEMVGWNENGLEKYNRSYYEMWEQLSLDLKSHVQSVEEAKAMLISHLNEQSGKNIDHSIWKKFIAAKRQLASTKRTIYCEVVISSRGYLKYNFPLSNYQRFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTW0</accession>
    <name>A0AAV6VTW0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_009339</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTW0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13990">
        <property type="entry name" value="STKc_TLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000037">
        <property type="entry name" value="Serine/threonine-protein kinase tousled-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF23">
        <property type="entry name" value="TOUSLED-LIKE KINASE, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="467"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="67"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="401"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8199491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="760" mass="87314" checksum="BDA8C5A9FC9A6595" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWU5</accession>
    <name>A0AAV6VWU5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWU5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="345" mass="38667" checksum="0B2D89CAA9E5CE73" modified="2024-11-27" version="1">MQLYSRIDNIRLVTGIMMLESKKELAVLETNLSSTSTKRSPFHLLSSIFSKKKSNSLDNDPPANKPTEFQSCSTANLYQAQHSVPKRCSTTPGPLDDYAADANFFSSATRRKNLKIDLETLHLSRQDNPYLKTLERFSLPEDTILTCADLNSLAEKALLQSEWHIDADGDVDIHQHLVRSPPPQFPQNITHFIYSQANSPKRQANQSNNTRVEDYSPEKRKKPLNPVHNKKETGTLDPGIREVLEYQKSQLIAGLQHSLNIGQAKFGTAPAHYTPVQVKARWTQDSGSKTLEKQVPHATSSLPGLTSCYFEMEGRRATLGPIRIGRTLSDSICLDNKLRKIGSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCS8</accession>
    <name>A0AAV6TCS8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007178">
        <property type="protein sequence ID" value="KAG8155693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCS8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="210" mass="23317" checksum="DF03B6D0BDE3586B" modified="2024-11-27" version="1">MLWGSQAAETKFKKPQNLVVKTISLKSSYPNAQTTSLTPKKTPIPKPIKPLVKKSSSVIKQRKRRIPTPKPPLQEFDIPPSILKQLEESIAKIEQKDDKQCKSSTIVTASLPSKVAVAPAQEEPTLPSYTASLVKELTQILQLPEYGEVKVKITVSPAGKIIELLVLQAESKANKLYLEKCLPNIVLPKYNEKVTLNNEQTFTLTFCNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCV2</accession>
    <name>A0AAV6TCV2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006804">
        <property type="protein sequence ID" value="KAG8155740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCV2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11137" checksum="55529032048ED4B3" modified="2024-11-27" version="1">MSPPGLSWEKIEGGGDLSSPDDPSFVAWRCLRKKRGKTDWSKSLWGNRVVCFTRFWDEDCLALSPGLCYVSIARRPEILTDPRDLYSPGPLLGNPEKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TD34</accession>
    <name>A0AAV6TD34_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_001018</name>
        <name evidence="3" type="ORF">JTE90_005999</name>
        <name evidence="5" type="ORF">JTE90_009303</name>
        <name evidence="6" type="ORF">JTE90_010932</name>
        <name evidence="8" type="ORF">JTE90_013565</name>
        <name evidence="9" type="ORF">JTE90_021206</name>
        <name evidence="7" type="ORF">JTE90_022064</name>
        <name evidence="2" type="ORF">JTE90_027507</name>
    </gene>
    <organism evidence="2 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006607">
        <property type="protein sequence ID" value="KAG8155781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010005824">
        <property type="protein sequence ID" value="KAG8160595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010005410">
        <property type="protein sequence ID" value="KAG8170458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010005401">
        <property type="protein sequence ID" value="KAG8170461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010005257">
        <property type="protein sequence ID" value="KAG8170534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010004965">
        <property type="protein sequence ID" value="KAG8170746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010003402">
        <property type="protein sequence ID" value="KAG8171906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010002445">
        <property type="protein sequence ID" value="KAG8172697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TD34"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8160595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8170458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8170461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8170534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8170746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8171906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8172697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13772" checksum="DBB10C098C85731E" modified="2024-11-27" version="1">MFHRFRKKPFHHRGTPTIKGPLYLILPQKYCHKIKYETSHSRQTVLDSPRPALHIAAGRGNNKGRKGRQASRVGHAHGIQLTPTRSPMLRSQYAPYSHRNNFRDGAARHGGRTTRREAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TE80</accession>
    <name>A0AAV6TE80_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Torsin-1A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_017470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006159">
        <property type="protein sequence ID" value="KAG8156230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TE80"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002276">
        <property type="entry name" value="Torsin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049337">
        <property type="entry name" value="TOR1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF2">
        <property type="entry name" value="LD13476P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21376">
        <property type="entry name" value="TOR1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Torsin-1A C-terminal" evidence="8">
        <location>
            <begin position="211"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8156230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="270" mass="30759" checksum="78A178EE0FB10FA2" modified="2024-11-27" version="1" fragment="single">LEQDLQDHVFGQHFVDHIIPRSLKGHIQNKNPKKALVMSFHGWTGCGKNHVSQIIAKNLYRKGTESAYQHLYIGSRDFAHKHDIYKYKATLRKDIEESTKKCGRSLFIFDEVDKMAPGVLDALKPYIDYHDQLDGVNYRKNIYIFLSNAGGTNITAVALKFWSEGKTREDITLKDIEHSISKGAFNEIGGLQHSEIVKRDLIDVYVPFLPLERKHVKQCASAALRRKGVIPNDKVLNKIANQLVYAPPETELYSVSGCKKIEHKVELFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEH8</accession>
    <name>A0AAV6TEH8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006135">
        <property type="protein sequence ID" value="KAG8156246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEH8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850">
        <property type="entry name" value="SORTING NEXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850:SF2">
        <property type="entry name" value="SORTING NEXIN-5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8156246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="61" mass="7036" checksum="F8E6F989944311D5" modified="2024-11-27" version="1" fragment="single">EMLLTRTNMLVEYENANKALDKAKPHKKQAAEETKLAAEKAFEDCSDIARQEASTFHKFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFD9</accession>
    <name>A0AAV6TFD9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Senescence-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005228">
        <property type="protein sequence ID" value="KAG8170547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFD9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41197" checksum="6A70EB7EB4B375FF" modified="2024-11-27" version="1">MVVRTTGLSTKKHEPSVRTCGSSRNEQDYYRNDDHQWVKTNLSRDVKRNEGPAFAVRIHTENQDQASFCPFALREVSVLAELALGHLRYHLTDDRPSQKPPESVLGADARYKEAARLGPRSVILTGRFPLNETAADIGYGPARKLHISIGFSRANRAHRHRKRRGLLHENRHLSRTSRFPGDTNLTKKRKNLPGSVGRLGVRLRYRTGPKDLAPCRVGEYNPIPFRSQRDQTRACVAFSADVSTFGTDFSITRTDAPCSTALHGNPSPASVIKALTEYCYSPRSALSPPWRSAGSRPAPVNARHRDFLLTAALNLQRKLCRSGPGSGPTLSVIIFRASCFVGSCYTLLSDSGFHDAIVDCLEQPKHLSWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGY5</accession>
    <name>A0AAV6TGY5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004576">
        <property type="protein sequence ID" value="KAG8171002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGY5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="236" mass="25940" checksum="A9B205D430320733" modified="2024-11-27" version="1">MSQPFGFPCTEQGFFYPQRRVPGGFPLGKTCADRGRETGARKLHYLPRFLKGPNRAPPDTARDAVFFYENSVPISGRADSRDPETPYKEKKIFPGGLPRTSPEFGCVTAPVPERTYFPCPGVGGKINPLPLLVGSPRGQKPSLGLRFGRRLAFWNGIFSDPFWGRPDPWFNAVHKGKPLFQLQSPRSHLRDLLLPPKICTGGAPKAPGSPRDPLKHATATPPTHARGKPPRGEALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TH77</accession>
    <name>A0AAV6TH77_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">6-phosphogluconate dehydrogenase NADP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_006943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004312">
        <property type="protein sequence ID" value="KAG8171189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TH77"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="3">
        <location>
            <begin position="185"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8171189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="474" mass="50907" checksum="413878F58C6943FB" modified="2024-11-27" version="1">MSATKEIQKTSKKSSKNSSKLIKPDKIKKEPLDPVSLDQPSLILPSTSDKEPLDSVSLGQTSLISLPSTSDIKTEPCDSQKGKRKFYSQSKANIKVEKKAPVGGYIKICKRSASDISNDSEDDLNGVDKNLSSILDGPMSDPCSSSSAGPSGSSSSSSAGPSGSSSSSSAGPSGSSTKQFVTTKKIGFLGLGMMGRQMVQRLLDTEHSVTFWNRSACVDYNSFLQQGAKAAPNPAAVIQECDIIICCVSDSVAVQSVVFGKYGVLEGLNKQKGNKSYVEMSSIDLKTSEDVAAFITDRRGRYLVAPMIGQRQDVTNNSIIILAAGNQEVFNECTSMFAAWSKKVFYTGIEVGKATKFSLLLNMMIATTYSALSENLAVVERSGTSPRDFMDFMSIIGHSDFAFPSLMDMGRKMLSNNDTVNTPVKHLQKNLFSAISLGNEFDQPLQLAVAAYSQFTRALAHDPDSDVSSIHKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THZ5</accession>
    <name>A0AAV6THZ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_005785</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004433">
        <property type="protein sequence ID" value="KAG8171095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THZ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000620">
        <property type="entry name" value="Zinc finger protein 263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF106">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8171095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="447" mass="52568" checksum="03AD91A43D7EBB0A" modified="2024-11-27" version="1">MSIPKESILYEIITSKSNDPIADENNAVDISIDVLDAHSIPVFTCNACFQNFLTKQLLQQHERTHTSAQENGNLNYGCVLCDYCFILQRDLEDHMDEHEKVYLHTCKECEKSFFYSYILQKHLLKHKQQFVCNVCRESFDDKNRLHEHEHLHLVNHLDENSILRFACELCSVMFPLKVDLETHYNDSHEGFNRFPCPMCNESYFFSFMLSRHKMTHMELKNVQCELCPTSFKTKKELNIHMKHKHLEKQFKCMECGKTFSLKRLLLRHNVSHTTLRPFPCSICGLAFKFKQNLDRHILTHTDTKYECKKCDQSFTRPSGLRNHMKLHNREPLACKECGKTYMSHTMLSKHIVQEHPEDTSARLYTCGICGKSSSFECKYCSRTFLQRPHLLAHHQFHHRGMELVFELPIQCTYCKQSCLLEAGLQKHHAKYNPSLEIKHQLNSEDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKS9</accession>
    <name>A0AAV6TKS9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_006724</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002946">
        <property type="protein sequence ID" value="KAG8172233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKS9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8172233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="192" mass="21888" checksum="A2484D0478B060C2" modified="2024-11-27" version="1">MFLHLPCGFDEGGPKIQFPRVQLALDYKQREFVAHSLLQQVLTAHWLEEFRSWPRLSLASKMLHCFVRFLMLPFLSLASFSDAMCWRIDSTSGKSCNVSSVDDAALVHEALFSVVLAKLAYFCQQSSRLGPFQVSMSRIVLQIAYFLAFCLLVITTFSIALTRMYAYYDGMKRKDKDGNTTTQLSTFSTFCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLC3</accession>
    <name>A0AAV6TLC3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002678">
        <property type="protein sequence ID" value="KAG8172468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLC3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="64" mass="7028" checksum="B03DFED0F4402759" modified="2024-11-27" version="1" fragment="single">VGYGRCLTDKPGKNNLLQDTEFQQPPGQLYPVKRECEFGVWAQFQNFSPFHARGAGAGGVSMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLP5</accession>
    <name>A0AAV6TLP5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002274">
        <property type="protein sequence ID" value="KAG8172887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLP5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="193" mass="22437" checksum="EB971BACC3219ED6" modified="2024-11-27" version="1">MARRQLSRTMTANQPKMNSMATDMGKLFLDGMFSDLTINVGFRKFRAHTAILAARSQVFVAMLQSDMKEKTEKTLAIDSDPEVFEHFLYYLYTGKARKMSVATALSLLLLADKYDIKDLKSEMVDFTRFHLSTSQVLDIFVAADLCNVDILRNEALHFIHCNLREIMRNKEWKTFRNRVDLVDEILEYMRSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLV2</accession>
    <name>A0AAV6TLV2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_019477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002615">
        <property type="protein sequence ID" value="KAG8172541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLV2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8172541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="119" mass="13748" checksum="763F91EECE75960C" modified="2024-11-27" version="1">MIVYYLSFIYPSPLYFHVYVVNVYYCVLITILSISIGETDLRQLLWCDKAMGRNRMDPSTLMTGSSPAEGLSHAPQTPQAIRRKGGQEVIQRRNLGRRRPSTRQRSHQSHMKTFAQVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPK7</accession>
    <name>A0AAV6TPK7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_000692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010001590">
        <property type="protein sequence ID" value="KAG8173631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPK7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8173631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="164" mass="17878" checksum="E1E66AE08B32158A" modified="2024-11-27" version="1">MALPRCYFDMSADGEPLGRIVFEIRADVVPKTAENFRALCTGEKGFGYKGSIFHRVIPNFMCQAGDFTHHNGTGGRSIYGDRFEDENFSLKHTGPGVLSMANAGPNTNGSQFFITTVKTSWLDGKHVVFGIVVEGMDVVKRIESYGSQSGKTNKTITVADCGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPW1</accession>
    <name>A0AAV6TPW1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_023755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010001706">
        <property type="protein sequence ID" value="KAG8173491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPW1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8173491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="338" mass="39386" checksum="90C3466B2CCEF1B1" modified="2024-11-27" version="1">METVLRGLSYEACLVYLDDIVIVGKEFNDHLINIRKVLTKLRYAGLKLSLSKCHFFRREVKYLGHIVSSAGVQTDPDKTEAVKNWPRPKDVHVLRSFLGLSTYYRRFVKGFSMIARPLHRLTEKQQKFTWTSECDEAFDHLKSVLTSASILAYPEPDKMFILDTDASKEGIGAVLSQEVDGKERVIAYFSKSLSKPERNYCVRRKELLAIVKAVEHFHHYLYGRRFLVRTDHASLTWLLNFKFPDLKIARWNQRLQEYDIKIEYRKGSSHGNADSLSRRPCPETCKHCTNAESKYGYEQPMVRLVNISYRILLSCYLYRILTLGVTRVCEKANWKTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQ35</accession>
    <name>A0AAV6TQ35_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_013055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001386">
        <property type="protein sequence ID" value="KAG8173974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQ35"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043395008" description="Neurotransmitter-gated ion-channel ligand-binding domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="3">
        <location>
            <begin position="53"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8173974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="186" mass="21232" checksum="A4A0805A75083D1E" modified="2024-11-27" version="1">MMKFTYCVFILVCFEYSFAVCEKNGIRNKRSGEGHADEEGSENDDEGHHEDHTAVLDSLFEHYDTSSSPTHGTGEPTVISVNFQLLSLDDISDTKMELVIDSRVTFFWKDSRLVTPECRDEGDCEDRFDLKSRESALWTPDLYVLNSRLARDHDHPTRNGMLYLIASGKVFLSKRYGCSNICTLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQA8</accession>
    <name>A0AAV6TQA8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001394">
        <property type="protein sequence ID" value="KAG8173963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQA8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8366" checksum="8802260141E7645C" modified="2024-11-27" version="1">MIFSSIPGSTSWYDPQELEYHYGQIVPSLPILRRAHLIPLPCRTDKVRFPPTQQNYIQGALDETCTQSGFLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQR5</accession>
    <name>A0AAV6TQR5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_022545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001242">
        <property type="protein sequence ID" value="KAG8174357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQR5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002142">
        <property type="term" value="C:stereocilia ankle link complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000079">
        <property type="entry name" value="Whirlin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF29">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="135"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8174357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="241" mass="27008" checksum="FE447501DEE4BBFF" modified="2024-11-27" version="1">MIYPYHEAARAVLSRLKAIALTQRHQRSPVSPRSPRSPHSPLARSPISRSPIMPRSPRSPRSPVSRSPCLLSPTSTPDSLQVPHIKVRRHRSLPDPHAIQARKKQQQVERMQQQRSNSVRLPGHRTIPEGNGRFRIIVKKTRPLLGIAIEGGADTTQPLPRIISIHNAGAAFDAGGLKVGHVILEVDGIQMSRRPHAEVAQLIAHAFYGTDRDQVEFLVVETNRSTEHEVRRTSIMVFDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSL4</accession>
    <name>A0AAV6TSL4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001190">
        <property type="protein sequence ID" value="KAG8174546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSL4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="150" mass="17199" checksum="DE177DB8268E0B27" modified="2024-11-27" version="1">MFRLYLTRTNGPPIVIKPDTDLLNFQFNDIQRDYISPWTLNSFSYPDNSIPQDAIAYSIRGIDQVLPLAARIIMDLNKPVACVDTATFYALINALPKEFDLGYIHPSRIDFSDLYNPVEVGRNVLQQLEKEQERCDSLNDDDDDVVILDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TT88</accession>
    <name>A0AAV6TT88_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001143">
        <property type="protein sequence ID" value="KAG8174786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TT88"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22307" checksum="5AF3142CEFE544AD" modified="2024-11-27" version="1">MQIDTGACVSILPEYLYRGIPELKRKPLIGDKVSLTTYQGEPWMCWLKLRSTFKIKKLKKKYAKVFGPQIGEIKGKEVNLHLKPNTVPKFCKARPLPYTIKPLVDKELDVLERAGIIARVPYSDWLTPIVVVRKSSNAIRMCADYKVTLNPVLETEHYKLPTTEEMFSQLAKEFFFSHLDFASAYQQLKVSPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTC7</accession>
    <name>A0AAV6TTC7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001134">
        <property type="protein sequence ID" value="KAG8174831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTC7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="146" mass="16544" checksum="1FF882892F0680E3" modified="2024-11-27" version="1">MESSNSSSEFPNGTPNNQITDSNSKKTWVPKSRPVPSDRKHGKKREHSPEKEWGKGKSPTRKNPDNSREDEGKDKPKEELQFQPTQQPPISIHAASTSTYPTNGYATSDYYAVDPNQNNYMMPQYNMYNTMNQWGASVSSSMPPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTI4</accession>
    <name>A0AAV6TTI4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_012651</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001152">
        <property type="protein sequence ID" value="KAG8174751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTI4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="15"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8174751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="254" mass="28886" checksum="C37FFCE24B1308C7" modified="2024-11-27" version="1">MRPSKSQYSSPLHMVPKKDSTDWRPVGDYRALNNQTVKDKYGVPNILDFTAELHGKTVFSHIDLVKAYHQIPINPSDVHKTAIATPFGLFESTRMQFGLCNAASTFQRFIDNVIRELPSTYAFIDDILVASTTEEEHLAHLPAQQTDGELTKIINSEETSLKLRKQACPFVPVDVVCDVSTGSPRPFVPQQLRKAIFDHFHNLSNPGISSTYRLISSRAAVKPDWRFYMYHRCQPIVPLRGYAHSLQLMEYPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TV72</accession>
    <name>A0AAV6TV72_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HID1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001020">
        <property type="protein sequence ID" value="KAG8175374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TV72"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="850" mass="95445" checksum="44A9054CF653DFCB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWN3</accession>
    <name>A0AAV6TWN3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000914">
        <property type="protein sequence ID" value="KAG8176179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWN3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="294" mass="34532" checksum="8048467CE2418C46" modified="2024-11-27" version="1">MYCQRQICRVPQVLSQERSYQITCRIQYSQNEGRKLDKVWTTLWNKVNGHPNVQPLIQVYWTTETTSFLMPYYSKNIAQEIDDMFCKNKKDGFEKVKKWLREVLSAMEYLESKGLCHLKLMSRYIFIAKDGRAVVGGLSRLNLANKPMESWDHKLLSVYFPPEFHPLNSFDGKFFDRWAYGILACECLTYLALRDVVKSSKNWRKHVYPTMCYIMDENNFTGFIRSAFPWGEKITDNEAKLALNFVQGFLRKDPKKRISPSDAMQHKFLGQDDEIGTGPDDMWTNHTFSFNLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYE0</accession>
    <name>A0AAV6TYE0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kynurenine formamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_015249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000821">
        <property type="protein sequence ID" value="KAG8177105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYE0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118:SF12">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043697780" description="Kynurenine formamidase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8177105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29780" checksum="D52B84881B155B34" modified="2024-11-27" version="1">MRVLLIFMCVAFGVYGAPLTRQMVDMTYTFDETTPYHPTLKKYERDTLVINEDPKDPYSAWIQLEEYASSTHAGTHMDAPRHFNKNGKTIDQLDITNFIAPAAVVDITRKAELNPDAEATVEDLLHWESVTGQNLNGTILMLRTGWGKKWGDKAAYYGAPVENPNPSQLHYPGISSVAAQWLVDNRNILGIGIDTVSFDSGASKGYPAHKILLGHGIFALENVAKMEDIPIYGAELHVMPMKIGGGSGAPTRVIAIFPEVVLPSTYFCHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYG1</accession>
    <name>A0AAV6TYG1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000844">
        <property type="protein sequence ID" value="KAG8176888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYG1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12320" checksum="4B27FA5F4644F222" modified="2024-11-27" version="1">MDGCVLAGCGAFFVVGIVLGWLLLHRKRGQPIQRTLVIAECIQPQLQCKPVPCQHPYYRVISECSEKPIEEQVRRDSCYKIQMPQSQNSKTYVPTPTGNNGKLSRSSVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYM4</accession>
    <name>A0AAV6TYM4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_003410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000849">
        <property type="protein sequence ID" value="KAG8176779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYM4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8176779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="13983" checksum="07E43D79AF44C527" modified="2024-11-27" version="1">MVSQKEKNYTCAACFAAFQTKQELKMHGSVHSDERPHLCCFCSSLFKQKTALDQHLKLHTGIKPYVCEDCNRSFTSKQNMQVHHARIHAIMKSGGNPRDLLPDDVKQETLDILETWTGPEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYU6</accession>
    <name>A0AAV6TYU6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SUEL-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_010164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000796">
        <property type="protein sequence ID" value="KAG8177247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYU6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22828">
        <property type="entry name" value="Gal_Rha_Lectin_EVA1_EVA1C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46780">
        <property type="entry name" value="PROTEIN EVA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043361242" description="SUEL-type lectin domain-containing protein" evidence="3">
        <location>
            <begin position="32"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="4">
        <location>
            <begin position="51"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="4">
        <location>
            <begin position="141"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8177247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="394" mass="43348" checksum="BBDE8AA1DC3C0940" modified="2024-11-27" version="1">MRGIVFHQKMDTNLLLLHLGLLFCLVLGVLGRAEDEYGLWHRTLTPFQAHACDGEALQLECTPSTVISVHYVSYGRQVNAGHLCPGSATRGAAAHCDSSKGALQVIHRRCHKSTNCRVLITPSLFGVDNCPGARKFIEVVYKCRPDCLIAQSDETIRSLCSGRQNCSLMADDRTFGNPGCRQGNKYLKIAYNCVEKELLLPNVRRSEDYSIVTTSFPAWASGLDLSAGHSFRPRGVSDTTTDSSSRTSSSDMQSDEVPADYRRDPTSLSGNQEVVGFMSDWVAAHKHMKGNKDKLILYLSISLAVGFVACISVLAGRYVIIRLESRRSSRADISANHLEDPFLGEHVLDHYDPPRVDTPPPPPPLPSTSSFRKDSEVLPRAPVNTGSDLNHYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0J2</accession>
    <name>A0AAV6U0J2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_021143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000748">
        <property type="protein sequence ID" value="KAG8177810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0J2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8177810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="207" mass="23945" checksum="F51E7D70BBF97D92" modified="2024-11-27" version="1">MEPIPSPQEILSTKKGKPSCLILDGFKYRIHRTTKCNIRWTCTEEKQSKCKGSVTTNLNHQVLRQVIHSCIPNPVAIDVKRKLAVVQKKEYVKNRRCPFLFFDGTFQSCPRQFIQLYTVHVDLGSTKEKTKVFPVLYALLPDKKQVTYTDLLHQIKIRCPSWKPKLIKLDLNKPQSTVVGRNCLKRKFLVVISILISVYGEKFKTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0Q9</accession>
    <name>A0AAV6U0Q9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 14">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_015931</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 14"/>
    <dbReference type="EMBL" id="JAFNEN010000783">
        <property type="protein sequence ID" value="KAG8177377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0Q9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000003">
        <property type="entry name" value="Signal peptidase complex catalytic subunit SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S24/S26A/S26B/S26C" evidence="15">
        <location>
            <begin position="34"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8177377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="177" mass="19923" checksum="5E15241B120AE2C8" modified="2024-11-27" version="1">MLDCMEDLKRMNKRQLVYQVLNFGMIVSSALMIWKGLMVVTGSESPIVVVLSGSMEPAFHRGDLLFLTNHRQDPVRVGDIVVFKVEGRDIPIVHRVLKIHEKGNGTVKILTKGDNNSVDDRGLYAPGQLWLEKKDIVGRARGFVPYVGIVTILMNDYPKFKYAVLGCLGLFVLIHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1D1</accession>
    <name>A0AAV6U1D1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000719">
        <property type="protein sequence ID" value="KAG8178060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1D1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11362" checksum="9FEFE6D3A3B2AD01" modified="2024-11-27" version="1">MINQGICRPSKSSWASPLHMVPKKDGDWRPCGDYRRLNNVTKPDRYPIPHIHDVAQQLEGKTIFSTIDLFRAYHQIPVREEDIQKTAVITPSVFSSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1U2</accession>
    <name>A0AAV6U1U2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_024607</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>glycine + S-adenosyl-L-methionine = sarcosine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57433"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.20"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19938"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000738">
        <property type="protein sequence ID" value="KAG8177898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1U2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017174">
        <property type="term" value="F:glycine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006111">
        <property type="term" value="P:regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046498">
        <property type="term" value="P:S-adenosylhomocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046500">
        <property type="term" value="P:S-adenosylmethionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901052">
        <property type="term" value="P:sarcosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000113">
        <property type="entry name" value="Glycine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.46.10">
        <property type="entry name" value="Glycine N-methyltransferase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014369">
        <property type="entry name" value="Gly/Sar_N_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16458">
        <property type="entry name" value="GLYCINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16458:SF2">
        <property type="entry name" value="GLYCINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000385">
        <property type="entry name" value="Gly_N-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51600">
        <property type="entry name" value="SAM_GNMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="7 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="14">
        <location>
            <begin position="45"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000385-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8177898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="275" mass="31682" checksum="B9E45C8E3496E885" modified="2024-11-27" version="1">MDAQADAIVADGWDNYIGDVDHRLANYAEFLVEFLKKKNSRHIYMDAACGTGIDSIMLLENGFKVTSVDSSDNMVKLTLKKRWKRREERAFNEWVIQKADWLTLPQKLAKPDKGFDAIICIGNSITYLLDMGDIQLAIQNFHYMLKPGGWLIIDHRNYGAILVSGCWPKTNIYFNGKIFNDNTVENTSKLIIRDVCVGVSSDKETDLSNYTKENGTSHKKKFRFINFPLQLKDFTRDLKEVFGKGSKYEVYGDYKPLESFENPAFFIHFIQKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U221</accession>
    <name>A0AAV6U221_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 5">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_029445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 5"/>
    <dbReference type="EMBL" id="JAFNEN010000714">
        <property type="protein sequence ID" value="KAG8178139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U221"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000001">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="8">
        <location>
            <begin position="154"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="9">
        <location>
            <begin position="327"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8178139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="514" mass="58944" checksum="9F028FB5819928BD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U278</accession>
    <name>A0AAV6U278_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">JTE90_026719</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the type II pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000766">
        <property type="protein sequence ID" value="KAG8177641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U278"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000025">
        <property type="entry name" value="pantothenate kinase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="79"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG8177641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="762" mass="86519" checksum="5B93E51249D700E8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2L3</accession>
    <name>A0AAV6U2L3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Down syndrome cell adhesion molecule</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_024066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000720">
        <property type="protein sequence ID" value="KAG8178053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2L3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
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        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
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        <property type="entry name" value="Down syndrome cell adhesion molecule like 1"/>
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        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="103"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="203"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="304"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="405"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8178053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="55820" checksum="4455A6A19304CD4E" modified="2024-11-27" version="1">MVFQMPPVIDAHYFRESITVDEEARTKLMCVVIQGDPPMRFRWLKGGQTFLAHGDTTVQTFEDTSIVTFKKVVSSDRGQYTCVAANVASSTNRTMNLVVNVPPQWTVEPRNVSVVLGHRVWIDCAAVGFPAPSILWKKLLHSESSAGDFTYVHSNPRAHRFNNGTLVLSDVQETDAGAYLCQATNGIAAGLSKIITLQVLVPPKFKEPFQTKTVTEESNTTLRCIASGHAPIVITWQKDKSLIDIVKRGRFSIRDIADSQQTMSELQILKTHRNDTGTYSCSAVSDIGTDEATIQYTVQGKPDSPSNISIVNVTSRSVTLQWDVRHDGNSHVTGSVVQYQSISDSSWNGQTSQLIVSGSESLATLRSLTPITLYFIRIVAENMLGHSAPSDVINATTAEEAPSGTPREVQVHSTGAQSMKVSWKPPPDDVTNGQIRGYSIGYRVSSASEAYTFKQVERSSTTANGEKEALSTYITGLQPFTKYDIVVKAFNSAGMGPKSAKITGKTLETEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3Z5</accession>
    <name>A0AAV6U3Z5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein RFT1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_026555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000695">
        <property type="protein sequence ID" value="KAG8178456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3Z5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8178456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="526" mass="60428" checksum="9C930F0AFA0C1A9A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5Z0</accession>
    <name>A0AAV6U5Z0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Fibropellin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">JTE90_016418</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000638">
        <property type="protein sequence ID" value="KAG8179313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000368">
        <property type="entry name" value="Delta-like 3 (Drosophila), isoform CRA_b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000014">
        <property type="entry name" value="Membrane cofactor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000279">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000109">
        <property type="entry name" value="Notch homolog 4, [Drosophila]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000146">
        <property type="entry name" value="Putative neurogenic locus notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000053">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000018">
        <property type="entry name" value="Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000309">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="EGF-like" evidence="25">
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    <feature type="disulfide bond" evidence="20">
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    <feature type="disulfide bond" evidence="20">
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    <feature type="disulfide bond" evidence="18">
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    <feature type="disulfide bond" evidence="18">
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    <feature type="disulfide bond" evidence="18">
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    <feature type="disulfide bond" evidence="18">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAG8179313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="31">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3560" mass="389391" checksum="C3380CC979228644" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6R1</accession>
    <name>A0AAV6U6R1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_017791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000609">
        <property type="protein sequence ID" value="KAG8179650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6R1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF14">
        <property type="entry name" value="TTF-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="390"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8179650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="53206" checksum="EFF4005C5FF8F6FB" modified="2024-11-27" version="1">MVDEASDSLIHEQVSFCIRTVDDSLIINEDFISLYETPNTESQTLFIILKDIFARLDLSMDNLRGQCYDGASNMSVEDSLRHLTSMRDIMALAKDLINTVRESNKRMGLFRTIRYESANDQAGLRPLCPTRWTMRASSISRILKNFEELLEFFETFSVEDKTEAGYKCAGYRESMFQFKTYFFLRLYCHAMNPVENVNEKIQSPHLSVADLENIYEGLICILKGRRDSFENFWELCLKEKPSQVEPPSLPRKRRIPKKYENNESSSSSPHTFKTLKEYYKALYIEVCETVQSCITERFASTGLTEVIAVEQECLLLVNRGETNFEKSTEFFKSDLDIERLCLLLNMLADIANKKKLVLKNMRDVRKYIIQEPAVGEMLCKVVKCIKLLQVVPITTATSERSFSGLKRLKSYLRSTMGQKRLNNLAVLHAHRDVLDELDIRPVINDFIFTNSVRRSTFAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7D8</accession>
    <name>A0AAV6U7D8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000592">
        <property type="protein sequence ID" value="KAG8179987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7D8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="133" mass="14567" checksum="B3587DD1F3A7458B" modified="2024-11-27" version="1">MGVGVPRSLGISNSFREILGADSSGYSEIDRFWSSCKNKEMLQSAAATSFIEKAKMANFTTVLSRTITGDNDSRNAKIVMNKEVQICSDLRTFVEEADGRIVMHLFHAVQSGDITLYYSGCISNSSKALNVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8C5</accession>
    <name>A0AAV6U8C5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000578">
        <property type="protein sequence ID" value="KAG8180201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8C5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="414" mass="48189" checksum="F061123C81142489" modified="2024-11-27" version="1" fragment="single">DSDKYKYQDAYYWKDGPNENVELVGFRVFNDSKEDLQEKQIDMPDEEETKRESQISSETEIEMMESNHQISSVSSQAVVPSSDEVLPAKDILLQTAKADLPFPMITNFPDVVVKIGKNKFPTTKKVLCDYSEYFYERLASNKERLCVLKVDEKFVNPEAFKTILQFLCFKQPFTGQNLTKEVIHTATFLGMPLIICKIETILYHRIGSVENALAKLSLISEMREHLEKCPSVANLPFKKTQVTVKGQRGNLKDKHLLEMCHLEHIWKEKEWFFKASIERDRERSICEKIVMRPHVLVEKAESLTLWVFNVFNHNYKDAVYVNLEDYKKSLEDGLRGCTEFLANRIEEVALRSDCLTWNKALIDMMDEAMTKDEDAVTNQSFLQRTLKEKRLMVWELHKSECKILNPGLKTTDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8Q1</accession>
    <name>A0AAV6U8Q1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000559">
        <property type="protein sequence ID" value="KAG8180630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8Q1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF14">
        <property type="entry name" value="TTF-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="4"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="247" mass="28338" checksum="5AA7D710B6F7ADED" modified="2024-11-27" version="1">MTNRSVVSQLNEQLDSDMKKGRLALETIFTTVQFLCRQGLAIRGHEDVYSNFFQLLELRKNDVPELKDWLGRSGYKWTPHDIQNEIIDLLGKSVLKKVLASIKKTEHFSIMVDEASDSSIHEQMSFCIRTVDDSLIINEDFIGLYETPNTESQTRFIILKDIFARLDLSMDNLRGQCYDGASNMSVEDSLRHLTSMRDIMALAKDLINTVRESNKRVGLFRTIRYESANDQAGLRPRIPDSMDYAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9J9</accession>
    <name>A0AAV6U9J9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3'(2'),5'-bisphosphate nucleotidase 1</fullName>
            <ecNumber evidence="15">3.1.3.57</ecNumber>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">3'-phosphoadenosine 5'-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Bisphosphate 3'-nucleotidase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Inositol-polyphosphate 1-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_015809</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:70319"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:83241"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70320"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15553"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58282"/>
            <dbReference type="ChEBI" id="CHEBI:58469"/>
            <dbReference type="EC" id="3.1.3.57"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15554"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.57" evidence="15"/>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000544">
        <property type="protein sequence ID" value="KAG8180884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9J9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004441">
        <property type="term" value="F:inositol-1,4-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000006">
        <property type="entry name" value="Bisphosphate nucleotidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF5">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0452">Lithium</keyword>
    <keyword evidence="7 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="18">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8180884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="182" mass="19647" checksum="2C275700899FA7E7" modified="2024-11-27" version="1" fragment="single">LLDHVTVLIGLAVNGKAVGGVIHQPFYNYQHEEDITKLGRTMWGIVGAGGSGVSHQVPPEGKRIITTTRSHSNPIVNSTIAAMKPDEVLKVGGAGHKVLLLIEGKAHAYVFPSKGCKKWDTCAPEALLHAFGGKLTDIQGKPLKYHADVEHPNNQGVLATYVETTHEWYTKNVPKETTEALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9K0</accession>
    <name>A0AAV6U9K0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000559">
        <property type="protein sequence ID" value="KAG8180553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9K0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8343" checksum="315FEB89989C0AA4" modified="2024-11-27" version="1">MRVQLLVARLGIKASSKLGLKLKTNIMLQKAPVMTTPPEDVISLYSGICIGHLSRDGTKGCSYALTASPKLQHLGGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCI4</accession>
    <name>A0AAV6UCI4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasomal ubiquitin receptor ADRM1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_028263</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May function as a proteasomal ubiquitin receptor. May promote the deubiquitinating activity associated with the 26S proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000498">
        <property type="protein sequence ID" value="KAG8181724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCI4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2020.20:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.70:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="11">
        <location>
            <begin position="15"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="10">
        <location>
            <begin position="281"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="195"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8181724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="406" mass="43002" checksum="CB77BA303041F449" modified="2024-11-27" version="1">MTRPFLFGGSSSSQSQNKYLVEFRAGKMSMKNMVVSADKRKGLVFVYQTDDSLMHFCWKDRTSGIVEDDLIIFPDDVVFKKVPECTTGRVFVLKFKSSSRRCFYWLQESKTDRDNEYCCKVNQYLNNPPASGSSRGGASGSLGGSSTPSGGAAGLQSELSNLGDGDLQNLLNNMSQQQLIQLLGGVGGISQMPSLSSLLGGSRPSSGQSVSSSSESTHSIAETTPPARTTSSTAASTQPAATPAPVAAAATTAAASSSNPNIQLSDLQNILSGLTLPPGAEGAPKPSVDLSSAITAEALQPLFSNQELMDRVRTFLPPEASSTPIDSEQLRSTVQSPQFQQALGMFSAALQSGQLGPLMQQFGMTDDVVAAATSGDMDAFVRALQRSKESSKDKKDEDKDEDMALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDG6</accession>
    <name>A0AAV6UDG6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase regulatory subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_014823</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000500">
        <property type="protein sequence ID" value="KAG8181691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDG6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09942">
        <property type="entry name" value="SH2_nSH2_p85_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 3-kinase regulatory subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000100">
        <property type="entry name" value="phosphatidylinositol 3-kinase regulatory subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032498">
        <property type="entry name" value="PI3K_P85_iSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035022">
        <property type="entry name" value="PI3kinase_P85_nSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF10">
        <property type="entry name" value="PI3K21B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16454">
        <property type="entry name" value="PI3K_P85_iSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00678">
        <property type="entry name" value="PI3KINASEP85"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="150"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="396"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="671"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8181691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="777" mass="87715" checksum="C5DDA17CDFFD58A4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEL6</accession>
    <name>A0AAV6UEL6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein phosphatase 1 regulatory subunit 37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_017144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP1R37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000477">
        <property type="protein sequence ID" value="KAG8182193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEL6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF9">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="809"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8182193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="902" mass="97431" checksum="C0205CB4C7D0F645" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEX9</accession>
    <name>A0AAV6UEX9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID 150 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_001471</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000494">
        <property type="protein sequence ID" value="KAG8181816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEX9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000018">
        <property type="entry name" value="transcription initiation factor TFIID subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000003">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="9">
        <location>
            <begin position="271"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="10">
        <location>
            <begin position="521"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="11">
        <location>
            <begin position="641"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1075"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1128"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1075"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1140"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1173"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1196"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1220"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8181816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1230" mass="139571" checksum="FF3562F06E0BE2FC" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEZ7</accession>
    <name>A0AAV6UEZ7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_002662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000474">
        <property type="protein sequence ID" value="KAG8182231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEZ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052286">
        <property type="entry name" value="Wnt_signaling_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24364">
        <property type="entry name" value="LP06937P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24364:SF18">
        <property type="entry name" value="LP06937P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043876883" evidence="4">
        <location>
            <begin position="22"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8182231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="285" mass="32940" checksum="766DC18ABF9B48BA" modified="2024-11-27" version="1">MRMFHRELTLIICLAAVLVSAEMGCPSQEDVRPCECDPSENIMYPIVTLTCTKIDDSEVIQRVFENTKRYYFRTFALVESNLSYIPHMTLDDVKVITLSLYNVTLKYMFDEAPTDDTFLRELKAVRVKVLSGWDWKQLAGFKQLEQLDILDTPLKKLPADFRSSDHVPEEGNIRNFILMYNKISTVPSDMFSDMPLLGMVSLRGNMMAVLSEATFQPVVMSQLRYLDVTENPIQCDCRIAWVLQERRERISGKCYAPKALRDKAFNKLTREDIRCSNILLHSLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF25</accession>
    <name>A0AAV6UF25_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_017673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000452">
        <property type="protein sequence ID" value="KAG8182695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF25"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8182695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="58264" checksum="B496EC95AEDEC810" modified="2024-11-27" version="1">MEVTWLEDLVRQATDFFINNFVLNAVVVILVLVFLFSTRRGKNGKLPPGPFGLPLVGYVPFLTGNLHFDFVKLGKKYGDVFSLKLGMETVIVLNGMNVIKEAFSKAEFLGRPPHSFFSWITKHSPFFALGVPVWREQRRFFLHTMRDLGLGKSSVENEIESEIRHFLDVLRSHKGSPIDPIEPLSPSMSNNICALVFGKRYEYGHPDRQMLDSGLEDLVASNSQAAMPTFYPWIRHVPFIKKILGLGKAMAAGERICSFFRHEIEKRMKTFDTNVVRDFIDGYLHQMEDKKDDPTSSFNIDILVDTVLDLFAAGSETVRTTIQWCIYITAAYPEVQKRVQKELNDVLGRDRRPEFQDLRRLPYTNAVILEVMRWRTVVPINIMRYTVADTSVGGYHIPKNQIVMANFWAVHNDPSLWKDPETFKPERFLSADGKSVVKSGNLIPFSVGKRSCPGEAMANMEVFLYFSHILNEFEIAFPDGYKPTFDATLTATYKLNPYKVKFNERKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFD3</accession>
    <name>A0AAV6UFD3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000431">
        <property type="protein sequence ID" value="KAG8183135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFD3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="276" mass="30707" checksum="FE1BF4A1D74BE496" modified="2024-11-27" version="1">MGLCMSRCYTEVRRLSCWKPSSGIDDRDRLVDFDMFLDDQPAPRPLSISSWLSCVRGQFLVVSYVVFSLLSLEKELESSDVSLLHDSESEESDTLFELGFDNESLELQEEATVEAIKEAIKVKGIAEESTELVNPAKLAVDHAALWKLEKFYMDGKESSIERAGESSHASDGQLKDQATGSSPSSSVDLEWENEDGLSPVTHFSAREDPSSDTADCSQLSTPVSNGNEELEWDGHFTSTHITQLDMETERLISEIESEYCYWDSVISLSSGPTFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFJ9</accession>
    <name>A0AAV6UFJ9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulator of rDNA transcription protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000443">
        <property type="protein sequence ID" value="KAG8182871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFJ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15142" checksum="0EB6CF870BAC2912" modified="2024-11-27" version="1">MIGRADIKKSKSNVAMNAWLPRVSYPCSNSSDTSCIKLVKSKGLIGPAFAVRIHTENQDQASFCPFALREVSVLAELALGHLRYHLTDVPLQPNNPPESVLGADRALQGGSALGARSVILTGRFPLTRVSKETMKAVVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGH1</accession>
    <name>A0AAV6UGH1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IDLSRF-like peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_002854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000416">
        <property type="protein sequence ID" value="KAG8183472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGH1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053103">
        <property type="entry name" value="IDLSRF-like_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20967">
        <property type="entry name" value="PROHORMONE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20967:SF0">
        <property type="entry name" value="PROHORMONE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8183472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18265" checksum="59BF9A07EC7A3348" modified="2024-11-27" version="1">MLPADTDRCHPTQPFRCPGDRTVCISIQYLCDGAPDCADGYDEDPRLCTAAKRPPVEETANFLHTLIMNHGPNYLEKLFGNKARDALAPLGGMQKVAIALSESETLEDFGKALHLMRSDLEHLRNVFMAVETGDFSLLKSLGIRDSELGDVKFFLDKLVSTGFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGS7</accession>
    <name>A0AAV6UGS7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ionotropic receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_000450</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000445">
        <property type="protein sequence ID" value="KAG8182846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGS7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="12"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="127"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8182846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="50176" checksum="DB89FDC0EE51E73D" modified="2024-11-27" version="1">MKKFRVRYGTWVPFATFKYDKDNKKVLGGIVGDVYEGMKTFLGQFEYESHIQPDNTFGARLPSGSFSGMIGAVFNNETDIAGPFQISEGRSFGVEFTTPLGFSQIGIMSGMVPTNKDPFLIFSIFSMPVWITLFASLALVSATTTLIYHVLPSTEKRPLPEVFAKYFWAFQTSLVDENFGSSDRWFTRHICHSPSFRMLQLLWFIGPGLVLLYSYQGGIISAFAANKFKPKIATVEDLINDKSIGVISYHNAYPQKFFENLAGTKYSSIWARMKDHMLQFDLAGTVPKWMDSVENGENIFTTESTYLRYLVGYRFLKTGKCGIRVSNIDMGSTYIAIGFRKEYHGTDFLKRFNRGLRRFTEGSLAHLRLLHSNLYYDICTGVSSSTTKALGLSDLFGAFIVLGTGITVSILVFFAEVYVSRRSRTKVHWIPKAKVNDIVGNLSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UH06</accession>
    <name>A0AAV6UH06_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000459">
        <property type="protein sequence ID" value="KAG8182566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UH06"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10481" checksum="D8B3B4A75199682D" modified="2024-11-27" version="1">MSDVMGHGKGCATYVNCPKKQMARTPITDADEHLAESNMQEPRLSDTLSVLSGRGRSNLMYELAEGTGRNWEVDVFLYVHILKLLKLIMPDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJT8</accession>
    <name>A0AAV6UJT8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000392">
        <property type="protein sequence ID" value="KAG8183998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJT8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="244" mass="27597" checksum="F09ED0AF362733B3" modified="2024-11-27" version="1">MYAVSLINKNGKEVTCQEDSSNQTNDGSASNVFYIDTKNVLDALTPTSNTLTVCCKMWQEELNTEGLRICSELIEVSHLWTAENFKSYSFFSDTFIERNIRFFLTFDRKDESRQYTLIIGAAPINNDDTLNFVVYDNSIKDGGGKIESSLLLIFRFATRVEVKFVFSAKPNQTVHFRSICTVQSQFTRLQIPFIESTGQSKKDKSANGASYIYCGDFLNCDFPSQLCAHIMKICNSSFQVVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKE4</accession>
    <name>A0AAV6UKE4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TTF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000367">
        <property type="protein sequence ID" value="KAG8184634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKE4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF23">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="34093" checksum="A35E18096BD4987C" modified="2024-11-27" version="1">MVNEILDENPESFGNPMNAEKIVNDREKAYIRHFPENNFFILKADGTKEKREWHFYSETSDSAFCYVCKMFSKTGSQFSTRGCSDWKNISRRICEHKRSLDHRQSMFDFSKRSQQKGLIDTELIKQFENERQYWRHILKRVVATVKFLSSLGLAFRGNNESEGEGNYFSCLKYLAEFDPFLASHIKRYANHGQGSSTLREAEGAADPQPTWRIGQDHQEFDEGICWKYMGDANDPALREAEQQRLLQFVDRKSLRLDSPSVKQRVLKILNLRGGSIKTIRNVMREFAGNMGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UM99</accession>
    <name>A0AAV6UM99_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000341">
        <property type="protein sequence ID" value="KAG8185264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UM99"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="106" mass="12153" checksum="930401F17324BBF9" modified="2024-11-27" version="1">MTLAGQKLPRLYLLRMQEAEFTNQNFKYSSVHGTKRSRLNLLRHEKLNSIDSVTHLCRTKTLRLTCETLQEGLNVTTNSTDYTLCGPKTVHVFDLLRTARSLTVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMC9</accession>
    <name>A0AAV6UMC9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoprotein TPR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_023894</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000341">
        <property type="protein sequence ID" value="KAG8185282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="406"/>
            <end position="429"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8186959.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="48982" checksum="3BF3DD35B2C31865" modified="2024-11-27" version="1">MKIIKTCNLYLCFIVLGMCVAVPGPTLLDLQHLVHTDTKNIAFIYTARSIGYLVGSLGGGVLFDLLTRKQFVLTLFNLATAVTMLGIPWCRSIVALTAFMVGNGASLGVLDTGGNVCCLNLWGKDSGPYYQALHFAFGVGGLIAPLIAAPFLGSYSLGPVDLGGNNNSSNNNLFFINSTQSLNSNFLNGTFSSVFSKIPTVTYAYTIIGGIALLVTVLFLLVCIVDPVDANEQRTEEGQLRNRSVTFTFTIVFLTLILMFVETGTEIGYAQMLTSYAVKSSLRLSETVGSYMTSTFWAAFTISRFVSVFLAIKLSSLTLIFADIIITSVGSLILVFLGASEEWALWLATVLLGIGIASFFPAAVGWVEQYLTVTNKMAATFTVGAAFGEMVIPYTISYYIDEIPEVLLYIVPVSTVLSAIVVFIMYLILRKTQSKYVKDEGTVNPVCTSTVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USA3</accession>
    <name>A0AAV6USA3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000298">
        <property type="protein sequence ID" value="KAG8186533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USA3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="37"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="372" mass="42728" checksum="022CDFC8FDE327B9" modified="2024-11-27" version="1">MLMSGLREQFWVLKARKTIRDCLRKCTICQRFNNKHSEAQPGILPADRVSDTAIFEIVGVDLAGPLYIKGGQKAYIVLYTCAVYRAIHLELVTLLSTEAFLQSLRRFIARRGRPKIIYSDNGTNFVGANRVLKAVDWKRVSFQAVDHKIQWKFNPPSAACWGGWWERLIQMVKRILRKILGRAALTYEELLTVSCDCEQVVNTRPLTYVSEDVDVVAPLTPSMFLHEVKTSGVPDIDEVDNSELNKRSKHLQEIREVLRSRFRSEYLGQLCQQSFKDKLKNPIAVGDIVLLEDPNKKRTFWSMARVLKLITGKDGHKRLALIKTETTELLRPVQRLYRLELDIPINDKAEELINSEIVKTRSGRISKPPNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USZ5</accession>
    <name>A0AAV6USZ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_024099</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000287">
        <property type="protein sequence ID" value="KAG8186853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USZ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000502">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="10">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="457"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8186853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="489" mass="55191" checksum="C426698500D557B0" modified="2024-11-27" version="1">MSFRIVRSSKFRHIFGQPLKREQCYDNIRITSNSWDSSFCAVNPKFLAIVIEAAGGGAFMVLPLHKTGRIEPNYPLVTGHRGPVLDIVWCPFNDNVIASGSEDGIVRVWQIPDGGLVRPLTDPIVELIGHQRRVGLVLWHPTANNVLLSASADLKILIWNVGTAETLCSLTHPDLIWSVSWNWEGSRIVTTCKDKKIRIYDPRSGDMEQEAMGHEGAKPQKAIFLRNGLLFTTGFSRMSERQYSLRSEVAIAEPIVLEELDTSNGILSPIYDPDVNLLYLTAKGDSNIRYFEITDEPPFVHYISTYQSTEPQRGVGHMPKRGCDVHMCEIARLFKLHTKGFCEVITFTVPRKSELFQDDLYPDTLADTPAMSAEEWAGGKDSDPVLMSLKDGYKPKAQEFKLSKSKSNILDRMPSKAREKTEGVPKEKLDEIMEEIRKLKGTILKQEVRIRELEKRIEEAPRSTDLEGGQNQVNNNHHEPPVNILVDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTC6</accession>
    <name>A0AAV6UTC6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_022903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000270">
        <property type="protein sequence ID" value="KAG8187510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTC6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF0">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="696"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="792"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="955"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1096"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="724"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="799"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="819"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="851"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="929"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="955"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="996"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1025"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1055"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1107"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1125"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1166"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1193"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1215"/>
            <end position="1226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8187510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1226" mass="137788" checksum="B9318D3DD4F4EEFF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUW8</accession>
    <name>A0AAV6UUW8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_012113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000244">
        <property type="protein sequence ID" value="KAG8188280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUW8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098687">
        <property type="term" value="C:chromosomal region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12578">
        <property type="entry name" value="RRM1_hnRNPA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000040">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein A2/B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026:SF14">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026">
        <property type="entry name" value="HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="103"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8188280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="279" mass="30103" checksum="925B2E6F8985F66F" modified="2024-11-27" version="1">MSEKSEPEQFRKLFIGGLNYKSTEESLKAHFEQYGEIVDCVVMRDPHTRKSRGFGFITFGRASQVDDAQAARPHKIDGREVEPKRAVPREDSGKPEAQVTVNKLYVAGLKEDLGEEDLREHFGEYGNIVSVNVVVDKTTGQRRGFAFVEFDDYDPVDKACLQKHNVKGRRLEVKKALSREEMGNLRAKKDQRSGRGGGGEWRTADEFDRGGYGGGGYGGGYGGYNDGYGGGYGGGYSDGGYGGGGYGGGPMRGGGGGYSNRSAPYGRGGSRGGYGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVV1</accession>
    <name>A0AAV6UVV1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_008007</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVV1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF5">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 44 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8188440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="131" mass="15738" checksum="3CA05D7FFA63D3EE" modified="2024-11-27" version="1">MYSMHVIGPLKDPHLKRQDFDKILSELDEPICPYCKRIFSSRGNLRRHMEIHIMSDRKRFQCDICLKKYKRKDYLKEHKMTVHSPNNKWKFLRIATDDYYKEVGISKAFNLKKKVEKVNDVFPLVGVNNHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVV9</accession>
    <name>A0AAV6UVV9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_016940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000273">
        <property type="protein sequence ID" value="KAG8187396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVV9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="6">
        <location>
            <begin position="169"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8187396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="495" mass="56246" checksum="51834093E62C9576" modified="2024-11-27" version="1">MLRYPSLVSLNICRRLYSTQLSLNVKETLTRKPIDQKILVQGWVQTVRKHKKSCFVDLIDGTCLELLQEFSLILANSKASLAKGIGLFEEGNKKFFCGLPQYGSSIKVEGSLIKSKYQGQEVELIADTWKTIGACAEDYPFQYRTKYTSEHIRQYPYLRPRTRRFSSILRVRNHASMAVHKYFQDKGYCFIHTPIITQNDCEGAGEVFSVELKEKVKATPSNTTENKNTSDEIKVLKDENLTNNATLSNEESSEKFFGAPAFLTVSGQLHLEAIASSFGGGVYNFGPTFRAESSRTRLHACEFQMIEAEIAFITSLEDLFKAVENCIKEIIENITQNCVNEIQFLSQDLKNHDTYINNLLSKPFVQMSYEESISILQKSKDPIKFGEDLSAKHKISLIKHCDNIPVFAYCFDLFASYGGEICGGSLREEDVEKLRAKYAFDENSSLSWYLDLRKYGCPPHGGFGIGFERLLQSILGISNIRDIVPFPRRKYDCKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWE7</accession>
    <name>A0AAV6UWE7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWE7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043876892" description="Cuticle protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8188504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="18827" checksum="FA58F3917F13C9B0" modified="2024-11-27" version="1">MISKALILAAVVAVAVSHYIPEPIHHAPKPYAFGYSVKDHHGEQHREESGTGGHAVKGSYGFTDARGVHRQVEYVADGAGFRAKVKTNEPGTAPQSPAAVDMVSTAHVPYGTGVGYLLTPGAGYGGLGYSGAGLGYGGLGYAGAGLGYAGAGLGYAGLGYGAPGLGYAGAGLGGLSYGLGGLGYARYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UY77</accession>
    <name>A0AAV6UY77_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ankyrin repeat domain-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_008952</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000242">
        <property type="protein sequence ID" value="KAG8188311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UY77"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF13">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="11" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="320"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="638"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="779"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="515"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8188311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="90355" checksum="503CEE1265E89E4D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZS9</accession>
    <name>A0AAV6UZS9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyl-CoA synthetase family member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_000130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000196">
        <property type="protein sequence ID" value="KAG8190035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZS9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052091">
        <property type="entry name" value="Beta-ala_Activ/Resist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394:SF1">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="Beta-prop_ACSF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrrolo-quinoline quinone repeat" evidence="2">
        <location>
            <begin position="618"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8190035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="949" mass="106168" checksum="7ED48EF1E03165A9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0B6</accession>
    <name>A0AAV6V0B6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000218">
        <property type="protein sequence ID" value="KAG8189281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0B6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="119" mass="13095" checksum="4061FC03E6953796" modified="2024-11-27" version="1">MFVCINPSMHIHGTFDLSPFPPWKSRQTVSEMRLLKAGKLQDDEVFMSLMVHPKITSTKHHTNPILPIPPSNLHPLFVHSVPVSRGDSSAAKASAVFALSQIVGCRVSAGSPLPRSWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0S9</accession>
    <name>A0AAV6V0S9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000195">
        <property type="protein sequence ID" value="KAG8190069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0S9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="10890" checksum="0BB58278E40D29C7" modified="2024-11-27" version="1">MFKRSKIFGLSSGPHANNCKDSRKEPDFVTFPSRNLVDSQKSEKYRINISNPEFCAGTDYAVKQTSAVKQTLPVHKTMQYRSQPLFRNQHLFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1Q6</accession>
    <name>A0AAV6V1Q6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000185">
        <property type="protein sequence ID" value="KAG8190414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1Q6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10409" checksum="3E8588F2F52EAE06" modified="2024-11-27" version="1">MSRNSLNNGHRGQQNCMKLLFAANTDSTHDKPQSVKSLVLGNVGYFTQNDRPECHKSIMGFHSGSLSGGSFTWMSKSFTSWDLRGQIPMRVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2P7</accession>
    <name>A0AAV6V2P7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein wntless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_023027</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exosome-like vesicles. Postsynaptic wls is required for the trafficking of fz2 through the fz2-interacting protein Grip.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with wg; in the Golgi. Interacts with Vps35, a component of the retromer complex; wls stability is regulated by Vps35.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Presynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the wntless family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000195">
        <property type="protein sequence ID" value="KAG8190055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2P7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061355">
        <property type="term" value="P:Wnt protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053936">
        <property type="entry name" value="WLS_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009551">
        <property type="entry name" value="Wntless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449:SF2">
        <property type="entry name" value="PROTEIN WNTLESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21883">
        <property type="entry name" value="WLS_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless GOLD" evidence="20">
        <location>
            <begin position="71"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="19">
        <location>
            <begin position="277"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8190055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="563" mass="65952" checksum="FE30E4DE78105913" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4W1</accession>
    <name>A0AAV6V4W1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_026809</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000152">
        <property type="protein sequence ID" value="KAG8191770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4W1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8191770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="545" mass="62121" checksum="9553A2ADF2CF0E39" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5S3</accession>
    <name>A0AAV6V5S3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000146">
        <property type="protein sequence ID" value="KAG8192044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5S3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="8978" checksum="DDB175AF6C0DEDB4" modified="2024-11-27" version="1">MYPLSVRWTKSRGPVIMAVIWASAVALSSLQLVHGKAEKFTYAGQEFYDCTEVWEELDGKNGKGDGFCYHVELKPVSYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V622</accession>
    <name>A0AAV6V622_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000149">
        <property type="protein sequence ID" value="KAG8191932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V622"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="172" mass="19512" checksum="5906BFE6BB64CCCE" modified="2024-11-27" version="1">MQEQALASRATKKIKAKTKDGRGGWKNHFCLIPLSGGGTRETDRFMFRADDVNAMTRQNYLRAASVEEKRTASSGCQQRGPIPWSTNICCFASPAMAFSTQKRGTAAIRRSLCDETKICFTQHVGEACLTFAFTRQFHACGKKCQELWFEQKRFRYSCELCCSPIYNHTTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V626</accession>
    <name>A0AAV6V626_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000145">
        <property type="protein sequence ID" value="KAG8192087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V626"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="161" mass="18023" checksum="C6B00756436C044E" modified="2024-11-27" version="1">MVSKLLWNCINSPRIRSVCWDSNFDAPNSGSVDRIRTTHAWEISGKNSAVVRRTSVYPSKDNGAYERNLWIFVDTSSAQNCVLLSCTTSTSSSLVTMAVEDIIKVQLSQMTTAAMVFAEERLLRGGLETRAIVVEKSIKLNAFKASGIKLVSWWSLFQRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6K5</accession>
    <name>A0AAV6V6K5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Microtubule-associated proteins 1A/1B light chain 3C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_006089</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6K5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17236">
        <property type="entry name" value="Ubl_ATG8_MAP1LC3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000149">
        <property type="entry name" value="microtubule-associated proteins 1A/1B light chain 3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027731">
        <property type="entry name" value="MAP1A/MAP1B_LC3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8191343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16077" checksum="B8FF81A62D5CE671" modified="2024-11-27" version="1">MNKLFPDQSDKHGGATGTFKQRKTLATRKEEVENIRTKFPTKIPVIVERYHKESQLPLLDKTKFLVPQELTVSQFLTIIRNRMHLGANQAFYLLINNRSIASMSKTVAEVYLESRDEDGFLYVTYASQEMFGQCTSILKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V795</accession>
    <name>A0AAV6V795_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="19">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_018005</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:74111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:74112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:69819"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:69820"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:31979"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15724"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.14.13.148"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:31980"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18 19">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="19"/>
    <dbReference type="EMBL" id="JAFNEN010000139">
        <property type="protein sequence ID" value="KAG8192477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V795"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034899">
        <property type="term" value="F:trimethylamine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000159">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18 19" id="KW-0274">FAD</keyword>
    <keyword evidence="4 18 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18 19" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 18" id="KW-0521">NADP</keyword>
    <keyword evidence="10 18 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8192477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="519" mass="58135" checksum="00E2B70AE7545281" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V932</accession>
    <name>A0AAV6V932_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_019104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000135">
        <property type="protein sequence ID" value="KAG8192786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V932"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8192786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="687" mass="75592" checksum="40928E4543993D50" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VA50</accession>
    <name>A0AAV6VA50_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_003763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000119">
        <property type="protein sequence ID" value="KAG8193555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VA50"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000017">
        <property type="entry name" value="dnaJ homolog subfamily C member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF7">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8193555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="230" mass="25355" checksum="BB1750FA91F27965" modified="2024-11-27" version="1">MDRASRKLSTTGESLYQILELPKTSTKDEIKKKYRQLALKYHPDKNLDDPLAADKFKEINRAHTILSDETKKNIYDSYGSLGLYVAEHFGESNVNAYFVLSSGWCKALCCFCGIITGCFCFCCCFFCCCCNFCCGKCKPQIPDDDEECDKNEDGNASDTENEETKFKVRVENQGPSSSSSTPIVTQPSPSSSQPPPSTSAAIPLPPPDSQVSEKTSLKEKPQPTYATSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBB7</accession>
    <name>A0AAV6VBB7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000128">
        <property type="protein sequence ID" value="KAG8193168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBB7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="259" mass="29707" checksum="FCA9565C963B93BC" modified="2024-11-27" version="1">MSYAKYGKSAHLHLSAKRKLRDFRKGNNKKKIPLVSVIDDNTRNLSTLHGSTVRLDLDLKQQDATFYNSFNYKALAQTTDNRCPPDEFSSNTYNWLVEYEDESYIDNTELYPDLLPLGTEPELGGFFVNEGQLKMKCVVEPFKFGNVNQEKEIVRNPIKKPIISKKMRKKDFGIQQPKPNLSKKRGPKNDVNAKLDSILMVLLKGRMNAQNPSANINSKEVRAFRFPKAPVNNIPVIRHDFLSFQPRIKLPGKKLVNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBT2</accession>
    <name>A0AAV6VBT2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000106">
        <property type="protein sequence ID" value="KAG8194220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBT2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10299" checksum="59A4EE04F8CC4FF3" modified="2024-11-27" version="1">MDLGPSVLDLHSRPHSLIRLKGGPILPLGSTPMGYLKRSEEGIGRGCKNMLAGGCRLKRVCSQIESLRHEFWMILGWGVTRLQHLMSVFNIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDI6</accession>
    <name>A0AAV6VDI6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Orcokinin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000101">
        <property type="protein sequence ID" value="KAG8194617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDI6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043809472" description="Orcokinin" evidence="1">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="25981" checksum="30E135DFFDB958E7" modified="2024-11-27" version="1">MILYVSYFLLVVIESTILVSGQGGPRQNQLRLARDDKSLKPTFNGADVIYALIRTRSLDQFGGSQLIRTLDPLTGGQITKSVDQLATDAALDNFKGGEVIAVLDRLTGGDILGSLESVEGMEVLEALEKSVHAHGLHQHPKRTLDTLTGMAFGLSKRFDSLSGSTFGMSKRDFDEIDNVGFTGFAKRAPGGRGRGSTLALAKKNFDEIDRAGFEGYEKKNFDEIDRAGFESFEKRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDT8</accession>
    <name>A0AAV6VDT8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_024559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000106">
        <property type="protein sequence ID" value="KAG8194228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDT8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF96">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8194228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="574" mass="64386" checksum="170152989A205B67" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VG10</accession>
    <name>A0AAV6VG10_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_021414</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000096">
        <property type="protein sequence ID" value="KAG8194953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VG10"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000068">
        <property type="entry name" value="ALG5, dolichyl-phosphate beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="38"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8194953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="293" mass="33639" checksum="C5D15CAA125855B1" modified="2024-11-27" version="1">MPHIVRYEEEKYYLDSTSGTSSKKLFPSLDDEHSLYLSVIVPAYNEESRLPIMMDECLEYLENRLKRGAGFSYEVIVVDDGSSDATTKVALKYAGDYGSEKIRVLTLVKNRGKGGAVRLGMLSARGKYLLFADADGATKFQDIEKLEEEMKKSSAVNKNSVVIGSRAHLEQEAIASRTFFRTILMYGFHFLVWFFAVRTVRDTQCGFKMFTREAARGLFQVLHVERWAFDVELLYIAEKTRMSITEVSVNWTEIDGSKLVPVWSWLQMGVDLVLIWVKYQLNIWNVRDNKKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGF2</accession>
    <name>A0AAV6VGF2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuole membrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000092">
        <property type="protein sequence ID" value="KAG8195156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGF2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="47967" checksum="2B65897C15E3730C" modified="2024-11-27" version="1">MSESGDIAVKSRKSYENLATNGGIDNTFSMQYEASSLSNQTKQWIAIREDRKNLVLWKRPFTTLQYFVKELFINFYEYGTKLLQHQKVVLTSLLFIALSVVIYRYEGPHQKYVGRIEKEFLRCAYWIGLGVLSSVGLGTGLHTFVLYLGPHIAAVTLAAYECNSLDFPQPPYPDEIICPEGDYSNIVITIFMIMAKVRVEAFMWGMGTALGELPPYFMAKAARLSGQEHDDEDMKEFEELLQLKKGKGEQSYYYKAKQFVQKLVERVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAVIKMHIQKLFVIVAFNERQVHDLVSKMKFIPYIGKYLHAPLEEFLAKQKANLHRKHGTPGVSEGTWISWVYEKLVILMILYYVLSIVNSMAQSHHKRLNKRQRTSSKVATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHC2</accession>
    <name>A0AAV6VHC2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000076">
        <property type="protein sequence ID" value="KAG8195937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHC2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="66" mass="7411" checksum="A33A767A60C30F12" modified="2024-11-27" version="1">MVVIPFTETLLHCQGVLCSVSSTTNLNIHPQFDKPNEKSQSRETSSSIKPDIRIHSSFLSETQTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VI49</accession>
    <name>A0AAV6VI49_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000084">
        <property type="protein sequence ID" value="KAG8195549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VI49"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8406" checksum="771C1F5992C0D9BE" modified="2024-11-27" version="1">MDVSGSRSYLRRSSGTFMRENSSSERCIRILIDPTDVFWKESGMSVLVAFHSNDAWRSIPETVTRFFCYFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VI87</accession>
    <name>A0AAV6VI87_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_001100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000076">
        <property type="protein sequence ID" value="KAG8195861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VI87"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="81"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8195861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="252" mass="29232" checksum="F080B5D263E8C1D5" modified="2024-11-27" version="1">MEIVCYGVFTAVWWITSITLWPAVLLVKYFKFFRDKWFSWFVKILHPYLSPKLQMMRKKAFMSFDKHWPRRNMPQQHLEVLEIGIGGGEGNLKFYPENTNLTALDMDDDFKKPFTGHVKKNSQINSARAVVGSAEDMHMIEDSSMDFVVSSYVLCSVQDVHLVLKEVKRVLKPGGKFLFLEHVAYSKNHWSHLIVQKCAAPLWKVFFYGCVLDRDIGKTISQAVFSTVEMESDFPSSMWLFIRPQIFGVATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKX8</accession>
    <name>A0AAV6VKX8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_011303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000058">
        <property type="protein sequence ID" value="KAG8197140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.60">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032023">
        <property type="entry name" value="GCC2_Rab_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051841">
        <property type="entry name" value="MT-Golgi_org_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18902:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18902">
        <property type="entry name" value="NUCLEAR MITOTIC APPARATUS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16704">
        <property type="entry name" value="Rab_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="7">
        <location>
            <begin position="1925"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="941"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="40"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="216"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="311"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="482"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="583"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="712"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="853"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1018"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1294"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1434"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1602"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1881"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="948"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8197140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2000" mass="229653" checksum="173B7C7941972988" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKZ6</accession>
    <name>A0AAV6VKZ6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_009586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000071">
        <property type="protein sequence ID" value="KAG8196368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKZ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8196368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="188" mass="22068" checksum="F9F7BD94668C9097" modified="2024-11-27" version="1">MPATTLDIERGLEVAVIFDIKNCLPTCPMCLDTFSFRYQLEWHFQWKHRSEGNLFLCNECNEAFTESTDFKSHLTSVHNSLDILHACEKCGLRFKTDLELRQHHLTHKNERPYTCENCFRSFAKKNAFEQHLLTHVGRKVPELHKCRGCFSRRSFSLNHSKNRISECRYITCMRERVCAHGVGRTLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VL41</accession>
    <name>A0AAV6VL41_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VL41"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="296" mass="33502" checksum="2B04D364073AD68D" modified="2024-11-27" version="1">MIQLVIGQIYFDTEGPIMDDKGRMIGVTDNSESLKIRWNLVIKQGKSNKTTITHFDWKPKDEKDKGKPPIDEMIPDNKDKDKDKTPIDEKVPGDKDDQMKMIPDDIDEKMKRIPDDKDDQMKMIPDDKNKDKTPLEEKIPNNKDKTLTPAPLVQVYVVASGNGGAHTNIGDGGYYGRNNGYALSTGSATEDGKNKWSGGFSWDEKDWKDAQPRIPSQDWTQSSSWRIEDQKDINKHIAQIDGQSGGGGMVMSLSDDKLGEASTKYRISYLGLNLKPQSLAARTREKLLNWRLRFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMW4</accession>
    <name>A0AAV6VMW4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_013502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000056">
        <property type="protein sequence ID" value="KAG8197378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMW4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="59"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8197378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="458" mass="50881" checksum="332DA7735CB8C840" modified="2024-11-27" version="1">MAIDEVSEIISSDEEENDESEDDEEEEMEAEEIEEVEPAEGAEENSTTRVYLPQAGEDQENLECDESAYICYHVIKTGSPCLSFDILCDDLGEDRADQFPLTMTVVAGTEVKRVTGNQVLVMKLANMQKNKKKEEKDEDSEESDSESEDEDEKPVLTCAPIKHSGGVNRLKVTTLGSYQFAASWSELGKVHLWDLSPQLEALNDPRAMAAYVQAGSGSVQPEFTFTGHAHEGFAMQWSPLTSGMLATGDINKNIYLWKPMEGGTWNVDKRPFTGHTASVEDIQWSPTESNVLASCSADRSIRIWDMRAAPNKACMLTKNDAHESDVNVIGWNKTDPFILSGGDDGKLRVWDLRQFPDSSPICTFKYHTAPITSVEWHPTDHSVFAASSEDHSVSQWDLAVERDDTEEEGSETKDLPPQLLFLHLGQQEVKEVHWHAQMPGVMASASIAGLNVFRTVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQ30</accession>
    <name>A0AAV6VQ30_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_020318</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000047">
        <property type="protein sequence ID" value="KAG8197942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQ30"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000145">
        <property type="entry name" value="Glutamate receptor, metabotropic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000162">
        <property type="entry name" value="GPCR_3_mtglu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00593">
        <property type="entry name" value="MTABOTROPICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="9">
        <location>
            <begin position="75"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="9">
        <location>
            <begin position="506"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8197942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="563" mass="62276" checksum="8A03329CCD1097A8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQ64</accession>
    <name>A0AAV6VQ64_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_029367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000046">
        <property type="protein sequence ID" value="KAG8197972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47644">
        <property type="entry name" value="AGAP008221-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47644:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="1467"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1529"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1652"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1406"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1421"/>
            <end position="1431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8197972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1755" mass="195825" checksum="7B45F31F7B2E986F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VR59</accession>
    <name>A0AAV6VR59_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000030">
        <property type="protein sequence ID" value="KAG8199129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VR59"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7521" checksum="51471D196FC49E4A" modified="2024-11-27" version="1">MLLVSRSIDGLQDTEVRSRNVTISHELFPIPATPERVLEATEALMARELIPALFQEHSCSTLGRGKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRJ2</accession>
    <name>A0AAV6VRJ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein sprint</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_006884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000043">
        <property type="protein sequence ID" value="KAG8198131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRJ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01776">
        <property type="entry name" value="RA_Rin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF104">
        <property type="entry name" value="PROTEIN SPRINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23268">
        <property type="entry name" value="RIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="312"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="503"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8198131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="68081" checksum="9290EE381E6B1E9A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTJ9</accession>
    <name>A0AAV6VTJ9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">adenylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_021043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000032">
        <property type="protein sequence ID" value="KAG8199029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTJ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8199029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="191" mass="20876" checksum="125E4B219759D095" modified="2024-11-27" version="1">MADVKVPVIFVIGGPGSGKGTQCERIVQKYGFTHLSTGDLLRAECASGSERGARLVDIMKSGALVPNDEVLALLKNAIVDNVSKSNGFLVDGYPREVGQAVEFEKQVCSCTFLLFFDVPDDVMMSRLLERGKTSGRADDNEETIAKRLDTFHKFTQPILDHYGDKVKKVKATGKVDEIFAQVTQIVDACKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W0U1</accession>
    <name>A0AAV6W0U1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_027384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W0U1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF16">
        <property type="entry name" value="LHFPL TETRASPAN SUBFAMILY MEMBER 6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8201906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10088" checksum="8745BF4F46B1265D" modified="2024-11-27" version="1">MFLNHLTGLIAVLNDLLEASISVLIAAGCCIYPNGWSSREIRDVCGPESDAYRLGTCEISWSLYLLCGGVGILLLCVILSLKASRVKPNSFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDR9</accession>
    <name>A0AAV6TDR9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_021104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006335">
        <property type="protein sequence ID" value="KAG8156084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDR9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000195">
        <property type="entry name" value="Methyltransferase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF37">
        <property type="entry name" value="FIRE DANCER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="64"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8156084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="252" mass="28520" checksum="DDD2AC2D3A94CC82" modified="2024-11-27" version="1">MGDHPQQDDERQARSLALEKAYVHDVYDHFSGGGAPPVDAPRYRPWPRVRHFLMELEPGSLVADVGCGSGKYLDINPDLMKIGCDRCAPLVVQARSKGEVLRCDNLRLPFRDDTFDAVLSVAVVHHFATTDRRVAAIREITRVLRIGGKVLITVWAMEQRHRKFDSQDVLVPWHQPVKSSSEAEREVTSTTRDDDILVYHAYSHVSDHEKGQQQQGQSIRRGKKYRNGRGRYTVKNFVLGFTMILVPSSCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEI2</accession>
    <name>A0AAV6TEI2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_009674</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006236">
        <property type="protein sequence ID" value="KAG8156183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEI2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052795">
        <property type="entry name" value="RREB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46451">
        <property type="entry name" value="RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46451:SF1">
        <property type="entry name" value="RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8156183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="142" mass="15815" checksum="A383873A13D87CFC" modified="2024-11-27" version="1">MVLISMRVTRSNGPDLDACLRDPNGPDLDACYEIPMVLISIAQLDQHMKSHTGIKPYVCEDCNRSFTSKRNMVLHHARIHTIMKPGGNPRDLLPDDVKQETLDILETWTGPDAKVVVETDTGTMETDEDTGPEAEVVEVLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEY3</accession>
    <name>A0AAV6TEY3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005606">
        <property type="protein sequence ID" value="KAG8170364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEY3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="106" mass="10510" checksum="498CF94AF05E4955" modified="2024-11-27" version="1">MAVGPRPREPGNPNFTVGRHEGRSFPQGRNPTGGRWGNKFRNGGFGPQGAKAKKMVLATSNRGVARGRNSGGSQVGGGGPGPSGGGQGRRGGKGGGSAGQGNGDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFP8</accession>
    <name>A0AAV6TFP8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005519">
        <property type="protein sequence ID" value="KAG8170406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFP8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="143" mass="16154" checksum="C66EB644D022DA39" modified="2024-11-27" version="1" fragment="single">GIQVHYIQTRSKFGKSRFLVYPCFSKHLRLDGHSPASVKNLKKRTSVSMEYLTIDAGQDEMFDSSARPGILFALHSPYEPVNPYLKGALMKPGRSYQVHIQLHISFSVLKNEINVLTWARLARGTIRPSISPFVCSSIPFDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGI4</accession>
    <name>A0AAV6TGI4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_006938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010004648">
        <property type="protein sequence ID" value="KAG8170944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGI4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="48"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8170944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="302" mass="34991" checksum="DA2650ECBBF34FA1" modified="2024-11-27" version="1">MKTTHKVRERFYWDKLKSDVDKWCRTCSTCTARKGPNTRTRGRLQRYNVGAPFERIAIDVLGPLPQTTNGNKYILVVMDYFTKWPEAYVIPNQEATTVAEALLQDWICRFGVPLLLHSDQGTNFTSAVFTGLMDLLGVTKTRTTPLHPQSDGMVERLNRTILNHLSLFTHRNQNDWDQKLPLFLLAYRSAVHETTGLSPSQMLMGRELRLPCDLLFGRPPDDPSSPVEIFEDLKARLEDVHLFARERIDINTSRMKTRYDAKSHEPAFEIGDKVWFWNPKRRKGLSPKLQTFWKDPIPWSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGP8</accession>
    <name>A0AAV6TGP8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004564">
        <property type="protein sequence ID" value="KAG8171012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGP8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="353" mass="40583" checksum="8DA9BD0735A94623" modified="2024-11-27" version="1">MDEEWTIKRDYDASIENMKLNLAQKALYKWRLFCERKKQRKAYKNSEPLSPWLPMLMHTEYVTSGATNPFVIYKKHCALSRITDSKLKEIEKKSGWEPFETSHFESLSNQSPLPPAYLHTTGIVQYFKLGLVFVSYPDDVVSYFTEWMCQKFNLPSLPDARNKELASYSYVINGGRTVVSVTAIILGMENIGDCNEFMKGISAIILCCPSSFPNIMNFNVFVEKFDVLLKEANLLSAFPLFTIILDTNQKCNVLNQLSSFLDKRIYPEGCFSTLKMNHLPVRSGYVSNSSEVAKALKWLIVNQESRPILLCATLQNYLEDSYASAFNTLFWKISLEEFKPLVMVIQLFLSQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGV8</accession>
    <name>A0AAV6TGV8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004683">
        <property type="protein sequence ID" value="KAG8170920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGV8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="9312" checksum="26DCC971CFD631D7" modified="2024-11-27" version="1">MDATKLNPNQVLVTEGRYEECDKATSTSGTVSNLLFSNHEEARYEDFATMPTMQPNHGFGLSDCRAIQRHRCVSFASKNVSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THK9</accession>
    <name>A0AAV6THK9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004173">
        <property type="protein sequence ID" value="KAG8171308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THK9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF39">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="221" mass="25312" checksum="DEAB2D39FB339BEA" modified="2024-11-27" version="1">MNEDQIAQMKNLIWKYMKCFSNVPGKTELVMHDIKLSEEQSILSKPYRTSPRQNAILKTEIQKMLDLKIIEIGFSDCTSPMILVEAPEERIEIVSSAQCITVLDLSKGYWQIPLTERAQRLAAFVTNFGTYKPLRMPFGIQNAPYEFSKMVYQLLEGCEDRYIPIFSSIAAPLTDSLKGKARKGPITWTKECEEAFDKLKNCLCNYPVLYSPTRLPKTVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIA0</accession>
    <name>A0AAV6TIA0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003900">
        <property type="protein sequence ID" value="KAG8171497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIA0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="40" mass="4659" checksum="89FCA1FE7F4341DD" modified="2024-11-27" version="1" fragment="single">MFEAESEKYETGRASDSCGLPQQERRTPSLRRNTTNNLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIA1</accession>
    <name>A0AAV6TIA1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003957">
        <property type="protein sequence ID" value="KAG8171457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIA1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="8761" checksum="A5429EC895D24101" modified="2024-11-27" version="1" fragment="single">VVFSEEAKEKIKELSTNSSVGSTEKGAAVKLLTSIDLINEVPDRQAVTTISAERKCVNSQGSTRCIDAAVLQYAQSRSFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIG4</accession>
    <name>A0AAV6TIG4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004089">
        <property type="protein sequence ID" value="KAG8171363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIG4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="129" mass="14044" checksum="92C259DACE54728D" modified="2024-11-27" version="1">MEPFSTSVLRFSLEYLLLPPRSAPVAAPGGLTPGTFNARHRDPPTHCGVNLHEGSSGRSGPRIPTSWPSSDCLEQTNTFHGSHEASRIGPYGFWFYPRASSLYQKGPLGHSIPFVRPLSAKGILTPFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJL7</accession>
    <name>A0AAV6TJL7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_027898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003440">
        <property type="protein sequence ID" value="KAG8171876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJL7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8171876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="223" mass="25538" checksum="D9A42AF51CD7E41A" modified="2024-11-27" version="1">MIAGHTIIKVIAGLTEDQIAKYNAALSQAGIQAKKIIDDALAQVEEMRANVKNILEEEDKKMSKLIEEKVAKFKFEYTSFVLSYKLLKKVIKNVLNNKRNKSKFSSEETEKFRKDMLEYYKKSSEKYKKLDAEVNQMMNEALDKANSIIKHNRQQLDQTLDDNAHSNLKKVTDQVEKALGDLQANTASIAADAVKKIMHERKDDKRSSEVISSFSRDLNKKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLU3</accession>
    <name>A0AAV6TLU3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002431">
        <property type="protein sequence ID" value="KAG8172734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLU3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="195" mass="22116" checksum="BBFD15F903F5E820" modified="2024-11-27" version="1">MVCTVRSDERLEEIFKYERAYPPSLFDESGLMRKGSKSSMVTVLFPDSNETSIIKNSEKVSYIIDGGHLLHRVVWRRPATFKQICEQYSNYVTSHYGPATVVFDGYNEGNTKDEEHLRRSRSTTNIEVKVEDSINVNINQSEFLANSKNKMSLISLLTVHLQRRGGCTVNQASGDADLLIVLTAIVKLRKELKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQC9</accession>
    <name>A0AAV6TQC9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_012043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001591">
        <property type="protein sequence ID" value="KAG8173630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQC9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015889">
        <property type="term" value="P:cobalamin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002157">
        <property type="entry name" value="Cbl-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051588">
        <property type="entry name" value="Cobalamin_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559:SF18">
        <property type="entry name" value="TRANSCOBALAMIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559">
        <property type="entry name" value="TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01122">
        <property type="entry name" value="Cobalamin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="209"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8173630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="290" mass="32621" checksum="73E412602A20D154" modified="2024-11-27" version="1" fragment="single">MEKICGLLPMQPQPYFTFEGRQMRIDFRSDSYVDRSYSGFSAEYSFIDSVPPPTTTRTPPTTTRTPPTTFPSPIVTRSPREGLNDEVSLAKKKIVDWFMGLRRKGTQTKKWGHQLPRIAVALFLADQENFQLGNSTVYEMNTELTIQLLSKLQGGGHLKRRDLSIYIPALMVACVDPRNFYGRDLVAELRSDIESNNGTGSPFELLVLCNAGDAMSDRDVQRMATIFDSQHRPFWTDNQAMATLALACASAQPGVTVDERTLLDMAQELKKRQFRNGTVDNIKTTALVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRE7</accession>
    <name>A0AAV6TRE7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_024162</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001359">
        <property type="protein sequence ID" value="KAG8174016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRE7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="8" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="9" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8174016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="58711" checksum="61C20C405C815F8E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TS63</accession>
    <name>A0AAV6TS63_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IRF tryptophan pentad repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_020615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001118">
        <property type="protein sequence ID" value="KAG8174885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TS63"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001346">
        <property type="entry name" value="Interferon_reg_fact_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51507">
        <property type="entry name" value="IRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRF tryptophan pentad repeat" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8174885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="351" mass="40211" checksum="D45CFED8A2189AE8" modified="2024-11-27" version="1">MKGRYNPDETNYYMFSKQRFGAALKKQCSVRQLPSENRYVKEYQLLMDGDERKAMIHIGNLDSELQLYCRTKKWVVMATIGFGDDPFPNLGGLHSPGRRTPPNRARSRSPSLMRDLDFLDNLNFDSFLQNPPSNGNRGRSSPVLPELDVNSSDFVDHVQSPGRRTPSHGNRGRSSPVLPELDVNSSDFADHVQSPGRRTPAEGTRVSPNAFDHLDFDSVEFDRPLRVDIPDATVRAIHIPDPAVELNAIHNPDPFVESRPDSPEPPGIPRNTGRRRPGPRNRHLRWSGDRQTLEYNLGDQRIQFHNEEGEFATQKLPKRPCRLLLSHCSKNHPVRRDRPRNTVIRLRRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TS73</accession>
    <name>A0AAV6TS73_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prolow-density lipoprotein receptor-related protein 1-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_006649</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001201">
        <property type="protein sequence ID" value="KAG8174491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TS73"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032485">
        <property type="entry name" value="LRP1-like_beta_prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16472">
        <property type="entry name" value="DUF5050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043540700" description="Prolow-density lipoprotein receptor-related protein 1-like beta-propeller domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Prolow-density lipoprotein receptor-related protein 1-like beta-propeller" evidence="9">
        <location>
            <begin position="95"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="6">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="6">
        <location>
            <begin position="149"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="6">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8174491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="457" mass="50615" checksum="90226D165F88D461" modified="2024-11-27" version="1">MLNLRLAASMCVFTLSCLVTADDQDGSALYCDGDIRNFSLASGSDSLLMSGIETPRVVDYHIKSKVFFWTDFRNKINKAPLWQEGARPSVLSGVDSHGIAVDWIHNLIYWTEYNNGAIGVSRLDGSMVRTVLKERRINPHAIVLNPAEGFMFWSDCGLRHNIQRCTMDGTNRKVIVKEDIEIVNSLAIDLDSQRIFWVDYIKRHLSSAKFDGNHRRNLITGQKTPRSIDIYGQHVYFVAFQGRHNAVYKASKIDGSGLTKVFDGKETLRSLKVFHPSKQLEGYDVCGDDNGGCSHLCLPTSSHTFSCACPNDRNMSSDKFTCLNSDGSVLTTPRLTTNAPSSHLPFTIPQTNFTSSTGSEVTPSLNTNASTSQLPLLVFQTNVGSTTEMNKNVDATIGSSCTYGIFAVVIASVVLIAVAGMWIFRKLLKRTAAKISIQNIVQRRNCEENNLYTEALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSA0</accession>
    <name>A0AAV6TSA0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001204">
        <property type="protein sequence ID" value="KAG8174478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSA0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF2">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="101" mass="11686" checksum="EDF23567CC877355" modified="2024-11-27" version="1">MYSCGTLQKKRRHLPKELEGIKLKEQGSSHTFQCKEERIYSVPLGWTKKRIGILSTNVNDNIVKVKRRKGADKNEINCPLAFSLYNKYIGGVDLADRNRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTT6</accession>
    <name>A0AAV6TTT6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_017436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001132">
        <property type="protein sequence ID" value="KAG8174841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTT6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043753470" evidence="2">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8174841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="149" mass="17141" checksum="63B15C9CD2B87311" modified="2024-11-27" version="1">MTSTRYFFLFLCLAVLSSMALTQGVLISKYLQLQATPLWVKLSPRDDSRDTVLRRVKRPNQRIYLYFKTESLGCLPNPINLSMKFSPNGRPPPLAAPYRSAKSSDASPRDREETWFANQDLGSTEDPGRVEDWWMVKGWISLRRGEVHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUJ8</accession>
    <name>A0AAV6TUJ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_001513</name>
        <name evidence="4" type="ORF">JTE90_019715</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001021">
        <property type="protein sequence ID" value="KAG8175369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010000393">
        <property type="protein sequence ID" value="KAG8183980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUJ8"/>
    <dbReference type="SMR" id="A0AAV6TUJ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000527">
        <property type="entry name" value="Calmodulin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8175369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8183980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="149" mass="16811" checksum="6B44A8917FC7027B" modified="2024-11-27" version="1">MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVTMMTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWS4</accession>
    <name>A0AAV6TWS4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000918">
        <property type="protein sequence ID" value="KAG8176103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWS4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="85" mass="9430" checksum="296F731982CC7879" modified="2024-11-27" version="1">MKPQSVSMPQVTTLKFTDTSKTIKHCVIAIADFETITVKHSTVLPSTSKSFNAAIETHEPVSYGLIVIDSNDKILYQEYYAGSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TY58</accession>
    <name>A0AAV6TY58_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_011280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000898">
        <property type="protein sequence ID" value="KAG8176296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TY58"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF41">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043641721" evidence="5">
        <location>
            <begin position="24"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="7">
        <location>
            <begin position="42"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="6">
        <location>
            <begin position="52"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="220"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8176296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="295" mass="33332" checksum="40DB8B2F90351A05" modified="2024-11-27" version="1">MNPHSVITCNILFALFWVQKILCCYLPYQVGKSYGICEYLSPSLVRRADWGAADATGPLDCFWDPVDLIILHHTATKPCTTTDECKKAVKDIQEAHMKEKMWLDIGYHFLIGGDGKVYEGRPWYKVGAHTKYHNKFSLGIALIGDFDKECPDPVMLDLIPKIIFCGVEKGYVDPDFYLIGHRDAYCTTCPGDAFYKVIKKWPRFPRIVPIPTYTCDANETTTETPTTTAAPTTTPAPTTTTPKPTTTTPEPTTTTSKPTTAKPEATTDKDKYFVVVVPKPKFPWYLPWQTAEEWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYJ9</accession>
    <name>A0AAV6TYJ9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000866">
        <property type="protein sequence ID" value="KAG8176561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYJ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="115" mass="13293" checksum="1D130DAF77E7FDFC" modified="2024-11-27" version="1">MEPASRTDVDPNRSNKLDKAEKRLFEVMMSKVFNLRIVSGTMEGQNKWAKVLINWGKEKQFMQQCNTGSLDFDENYGKILECGFGDNIPSYPEVVNKLYEDIKENICLVKLKTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYX3</accession>
    <name>A0AAV6TYX3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="6">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_029421</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="6"/>
    <dbReference type="EMBL" id="JAFNEN010000791">
        <property type="protein sequence ID" value="KAG8177285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYX3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="9" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="9" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="15">
        <location>
            <begin position="82"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8177285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="260" mass="29621" checksum="833E4F9C4CD4D39B" modified="2024-11-27" version="1">MASTLTKISHVLGANLRNVCHQKMAARCVQSSVGVKENLSMFDPQQVKLLDEMCIAVDPNDKVIGPRTKKDCHLMENINKGLLHRAFSVFLFNTKGELLLQQRSDAKITFPGYYTNTCCSHPLYLDSELEEIKALGVKRAAQRRMAIELGVDLGSIAANEFLYMTRILYTAPSDSQWGEREIDYVLLVQKDVQINPNPNEVKDCIYISKENLKGFLDGVEEEGYKITPWFKLIAETFLPKYWDNLNNLKPLRDHKTIHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZ67</accession>
    <name>A0AAV6TZ67_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_021764</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000810">
        <property type="protein sequence ID" value="KAG8177173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZ67"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1770:FF:000001">
        <property type="entry name" value="Cytochrome b reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF0">
        <property type="entry name" value="LD36721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="36"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8177173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="264" mass="29700" checksum="8416DAEC519DBB83" modified="2024-11-27" version="1">MHFSQQEEERLIGAIMDSPSLDESQELGLFKVWLLISQLLGVVCIALVSAWCGKYLGGFAWQEDPKHQFNHHPFFMVLGLVFCYGNALLVYRVFRNQRKRSLKLLHFGLHSVALVFCIVALKAVFDSHNLAQPNPTPNLYSLHSWLGLTAVILFALQYVCGFVAFLFPGLTKLWRTKYLPLHVFFGLAIFVMVVAAALMGITEKLAFPGDYYKSPPTAVLGNLLGVCLIAFGLMIVYLVANPTYRRRMLPEEVQLQLEQSGSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZE8</accession>
    <name>A0AAV6TZE8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_009849</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000811">
        <property type="protein sequence ID" value="KAG8177156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZE8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="38"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="159"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8177156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="468" mass="54322" checksum="A248F01BEFE3104B" modified="2024-11-27" version="1">MILEFVIVEFPVLKLWKCDYIFSTTLFLNINKRLVMHFRVAVGEYFPFLILKMDNSQIQMTGPLAEAFQILANRANFTYSLLRAEGDVWGSLGPNGWTGLLGMLARNEVDFALGPFTMSYSRWKAFPMSVPMYADVVEMLVPSLDPNISLFNMVTVFSYQVWIMLLFSMFSFCMLLSTLDVYENVDKCFIRSFLNNFWDVTRTLLQKPKLRRPTGYQRVMLVVLWLLITLVISSIFCGVIQADLLLRRATKIDSIEDLNNSLDVLPIIEDQSSIYSAFKDGQSDIFQSIYAKALRSPEKSILTFKNMSTVGMDFVYAKSFAMITDGMGLRHFLRKRHREGLPCNFRLARETLWPLWKAIAFGDAFPKEWIRKFNGILRRLFESNWLYQRMIHEFSDYTECLRDGQEIGVETLNMRHVLGVFIIWGIGILVSTVVFLAEVYCLKKPTPKKFVKGPIYHGRIVYRSTLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0F3</accession>
    <name>A0AAV6U0F3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000793">
        <property type="protein sequence ID" value="KAG8177272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0F3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="202" mass="22611" checksum="F9830C292AD1A13F" modified="2024-11-27" version="1">MRISHGGVSGFTGLWFGFRTEVFYSVVEKEIHIEKCKQNSQQAFEYSLSLNIYIECIVPVHPIERESRRSLAERGADAGRRSERPLPHLSLWRWLLTFPPVAFCRPLPVRPVERSLPAQLSLFVGGLTKMANKRKTKDKRKPPSSSTSAPQTLTTSESESLSNYDDDVSRSLTFKEKPSWQVSLAALLAAISKGSTGSCKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1C7</accession>
    <name>A0AAV6U1C7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclin-dependent kinase 5 activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_015683</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Heterodimer of a catalytic subunit and a regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cyclin-dependent kinase 5 activator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000706">
        <property type="protein sequence ID" value="KAG8178272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1C7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016533">
        <property type="term" value="C:protein kinase 5 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000025">
        <property type="entry name" value="Cyclin-dependent kinase 5 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004944">
        <property type="entry name" value="CDK5_activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401">
        <property type="entry name" value="CYCLIN DEPENDANT KINASE-5 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03261">
        <property type="entry name" value="CDK5_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009324">
        <property type="entry name" value="Cdk5_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR009324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8178272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="343" mass="38612" checksum="F018EB8CBE926A64" modified="2024-11-27" version="1">MGTVLSISPRDRKPSYGEYTLNGFNYEQLNSNTKNKERNGNIVANLNQTHNTNFKKHSLFLNALSWKTLTSSSRRRGDKNKNGSRQPLDNLNNMVVDNKKNIQKSASCYNLKTSTVSALDMVVRANNASNDHNNKALAPPPSSKPSVLSASNLVRPLMNHINNNHLAPSGGTGRNKAVASSPSQQHRKTVIQASTSELLRCLGEFLCRKCWKLRDLQPADAVLWMRSVDRSLLLQGWQDIAFINPANVVFLYLLIRELVTDDIEDEKELQSVVLTCLYLSYSYMGNEISYPLKPFLVDDSKDKFWDRCLLIIDLLSGEMLRINSEPSFFTEVFTELKGCCSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2R4</accession>
    <name>A0AAV6U2R4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cathepsin L</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_017460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000717">
        <property type="protein sequence ID" value="KAG8178113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2R4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043608164" description="Cathepsin L" evidence="7">
        <location>
            <begin position="22"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="115"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8178113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36742" checksum="D79052DE1484DB8A" modified="2024-11-27" version="1">MSLKLSLVAVLMFVAINCVASFDSDLDDHWYNFKKTFCKVYTRREESTRREMFEVNVRDIFRHNLEHDLGKHTYRKGLNQFADLSHNEFVRQMNGYKGVKVNNSTAPFPQFTTPVPTAADWRDMGIVTPVKNQKQCGSCWAFSTTGSLEGQHALKTLKLVSLSEQNLVDCSGPEGNMGCEGGLMDQAFDYIKQNGGIDTESSYPYTAQDGTCYYKKASSGATCTGFVDIPTGDEKALQKAVAAVGPVSVAIDASQESFQFYQGGIYNEPQCSSEQLDHGVLVVGYGTENGKDFWLVKNSWDTTWGDKGYIKMARNQDNQCGIATQASYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U327</accession>
    <name>A0AAV6U327_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000663">
        <property type="protein sequence ID" value="KAG8178852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U327"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="10593" checksum="E5B098736517A63C" modified="2024-11-27" version="1">MDWPLGKVIEIIPGKDNVNRLVRLQTASSQLLRPIQRVFLLEVSSSWCKSFASDVSRAFKMPDNIPSPSSEVPDSVPYKTSRGRVIKVPQRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4N3</accession>
    <name>A0AAV6U4N3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Kinase D-interacting substrate of 220 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_010099</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000651">
        <property type="protein sequence ID" value="KAG8179069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052771">
        <property type="entry name" value="Neurotrophin_sig_adaptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057092">
        <property type="entry name" value="SAM_KIDINS220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116:SF0">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23307">
        <property type="entry name" value="SAM_KIDINS220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="8" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="9" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="700"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="KAP NTPase" evidence="13">
        <location>
            <begin position="443"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Kinase D-interacting substrate of 220 kDa-like SAM" evidence="14">
        <location>
            <begin position="1195"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1284"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1481"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1612"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1289"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1506"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1531"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1554"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1615"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1628"/>
            <end position="1649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8179069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1723" mass="193371" checksum="A50721211F49B4B8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6N2</accession>
    <name>A0AAV6U6N2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000595">
        <property type="protein sequence ID" value="KAG8179962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6N2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="9247" checksum="C6D591C7F5EBC747" modified="2024-11-27" version="1">MADFPTPLLPISHTVYFGTSLATSLAAVGTGLDDVDAVDSNSGKADAESEPLVGVVGVEHKDADLDLHRKESPLLTTPLEVTLKFLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7A1</accession>
    <name>A0AAV6U7A1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metalloendopeptidase</fullName>
            <ecNumber evidence="4">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_027914</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Zinc metalloprotease. Provoques deadhesion of endothelial cells from cell cultures, and also degradation of fibronectin, fibrinogen and gelatin in vitro. Its role in the venom is not fully understood but it might act as a spreading factor that facilitates diffusion of other venom toxins. Alternatively, it might be involved in the proteolytic processing of other venom toxins or it might play a role in extra-oral digestion of prey.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3 4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000577">
        <property type="protein sequence ID" value="KAG8180202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7A1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF883">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="5">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8180202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="203" mass="24113" checksum="A7238D90830B156E" modified="2024-11-27" version="1" fragment="single">LWLLTPQTYAESESVSRRHSRNFNRSQCHMKSRILKAMKYIQDRTCLQFIPKKSTSKNYIRFFNGDGCYSHWGWTGGEQPVSLGDGCDYFGTIVHELTHAIGFDHEQNRSDRDDYITIFYQNIEPEFVDQFQKLRPSENRLINKFDYDSIMMYGDTAFSIDGYKKTMKPKKKGVKLVDAYYKMPTDSDIYRINWLYMCQDYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8C2</accession>
    <name>A0AAV6U8C2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_020812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000600">
        <property type="protein sequence ID" value="KAG8179829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8C2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46595">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8179829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="116" mass="13253" checksum="C1D04D0B26A935FD" modified="2024-11-27" version="1">MVQRLTYRRRLCYNTQSNRVKISKTPGGRLVYLYPGKPGKIPRCGDCHLRLRGITHARPRELSALSKRQKTVTRSYGGSRCGKCVRSRIIRAFLIEEQKIVAKVLKAQQITSKPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8H8</accession>
    <name>A0AAV6U8H8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_023357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000581">
        <property type="protein sequence ID" value="KAG8180148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8H8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902742">
        <property type="term" value="P:apoptotic process involved in development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070782">
        <property type="term" value="P:phosphatidylserine exposure on apoptotic cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF10">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8180148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="529" mass="61289" checksum="AC5353D8784B2B65" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8I7</accession>
    <name>A0AAV6U8I7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_025358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000558">
        <property type="protein sequence ID" value="KAG8180652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8I7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="103"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8180652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="576" mass="64901" checksum="59F25FC5096AEAF4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8P7</accession>
    <name>A0AAV6U8P7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_016499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000575">
        <property type="protein sequence ID" value="KAG8180223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8P7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF41">
        <property type="entry name" value="GEO08203P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="34"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8180223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="138" mass="15525" checksum="5BE25C61D1F67B04" modified="2024-11-27" version="1">MFRTEDPASVLNGAVTTVLQRLRRLSQQQNKRTDQSYTLSEVSVHCNRNDCWIVVGDNVYDVTPFLDKHPGGFDVLMEQAGRDATMAFYGAGHHPSTFDMLEPFHIGNLAQHERVNIIGTVSNHSVWSRDRAKIVVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U999</accession>
    <name>A0AAV6U999_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_022762</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000564">
        <property type="protein sequence ID" value="KAG8180413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U999"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="947"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="225"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="297"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8180413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1083" mass="123585" checksum="08F55D12EF2E9D24" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UA50</accession>
    <name>A0AAV6UA50_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine palmitoyltransferase 1</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Long chain base biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Serine-palmitoyl-CoA transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_013170</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000528">
        <property type="protein sequence ID" value="KAG8181200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UA50"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000049">
        <property type="entry name" value="serine palmitoyltransferase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="113"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8181200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="482" mass="54296" checksum="B94BD1E80442CF6A" modified="2024-11-27" version="1">MSAVIEESPPETTFELYEMFVAFLQAPTYHLALEAVLVIWVFWLIFHKSYKPRRNELTEKEKDQLIAEWTPEPLVPHSDENNLPPHKPGFVTGKVGKFVTIDDKQYLNTVTHNYLGLVEHEKLEEAALKSLRKYGVGSCGPRGFYGTVDIHLELEAKLAKFMRQQEAVLYSYGFSTISSAIPAYAKHGDIIFCDEGVNFAVQKGLVASRSQICFFKHNDTDDLERLLVQQAEQDKANPKKAKVTRRFLVVEGIYMNYGDICPLPKMVELKNKYKVRLFIDEACSFGVLGETGRGVTEHYNIPIEETDLVTSTLEAAIPGYGGFCVGTSFIVDHQRLSGLGYCFSASLPPLQAGVAITALEILESDPSIVENLKKNCLYMHKKIQKIPDLITYSDPLSPVKHLYVAEPLQRTHAMNKLGRIVLYAFQKENVALTIAQYLDIEEHKLPPPSIRLIVTALLTEEDMDRIATVLNKACQNVENSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAI0</accession>
    <name>A0AAV6UAI0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000539">
        <property type="protein sequence ID" value="KAG8181011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAI0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="288" mass="31803" checksum="B07EFF75E70DE084" modified="2024-11-27" version="1">MYGDLSDKNLNQSSSSVSDMHSGAVMGHENLYLLDDSGNIPESSDSESVSSRQIFQLTSIEAQPSGTQSTENPSLPQTTTWRRDAVTRPDRSRTDLKSKYKNLKAASRKRLADEKLEIFLTGGGSKKISATEADALLVANGAVVRPLLNSWDSDAPYEAVTSDKLLSGVNDTRILRDIRGDVEEPENRCQLVTRKDLQNVKSSMGIGTTSISHVVPDELSVKVFVEQMADNILCYKEQNTGHYVLDKTDFMLAFMMPLQRKMLAEFGSDRICIDSTHGQLAMASNFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAS8</accession>
    <name>A0AAV6UAS8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_017503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6"/>
    <dbReference type="EMBL" id="JAFNEN010000521">
        <property type="protein sequence ID" value="KAG8181334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAS8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF8">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="104"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8181334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="347" mass="38322" checksum="218AA43EFEAEBA2F" modified="2024-11-27" version="1">MALHLTSKNICRTVYNKHTLLTSNAKSFINPLQSIKSNEQLRGYSRRRSWFKAKKPAYDIVDLCEVGTRRSVPEFVPKPPYAATGIENEPESQIQILDAESVRCMRNSCSLAKILLDEVARHIKLGVTTDELDAIAHSTCINFGAYPSPLNYRGFPKSICTSVNNIACHGIPDSRKLKKGDIISVDISVFYNGFHGDCASTYFVNQPDPMAQKLVEVAQLCLLEGIKVCHHGQKFCAIGNTISNLAKSQGFSVIPAFCGHGISSSFHCSPNILHYENEEPGIMQKGMIFTIEPVICEGAPDIVILEDGWTASTEDNSRSAQFEHTILITEEGAEILTVPDKFKPQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBD6</accession>
    <name>A0AAV6UBD6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_010938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000529">
        <property type="protein sequence ID" value="KAG8181163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBD6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043753475" description="Lipase domain-containing protein" evidence="6">
        <location>
            <begin position="30"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="156"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8181163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="543" mass="60251" checksum="B0A656311542C4C3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCD3</accession>
    <name>A0AAV6UCD3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenosine deaminase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_008838</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000519">
        <property type="protein sequence ID" value="KAG8181363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCD3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00443">
        <property type="entry name" value="ADA_AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000033">
        <property type="entry name" value="Adenosine deaminase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8181363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="351" mass="40303" checksum="0C0934A67D2C1AEC" modified="2024-11-27" version="1">MNSRNDDVYNFIRSIPKVELHAHLNGSLSNRTLKKLVSLKLEMNPDINKEYLSIPCLSPVRDLNQCFEVFSFISKVVDNPHAVYMAAVDTIEDFYNDGVRYLELRTTPKENDQDMTQETYIQSVLKAITHTTETTCKGMIVKLLLSIDRRRPLKYAETTLKVAQQLIGECSNIIGIDLSGDPSQGHIKNFLPILERGKQLGLKLAVHVAELPDQHEEVELLLKMQPDRLGHGTFLHPDKNGSSRNFELLKQLQIPLEICLTSNVACKTVPSYEDHHFKLFHKINYPCVLCTDDKGVFNTSLSDEYYLASQHYSLSKDDLFKISYESISYSFCTELEKSLLRQHWEEFKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCE7</accession>
    <name>A0AAV6UCE7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000539">
        <property type="protein sequence ID" value="KAG8180946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCE7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="412" mass="45917" checksum="D2F9A69B48EAA690" modified="2024-11-27" version="1">MSSLPSDDGSSRTTPPAFSALSPFAIEQDMSPRSGGSAPPKLIVTEARLCSPRKICRDMIFCKNSLNAHITTIKSQLEMLDNLGPNEVADREFFLIDLGNAKAFALSYRKKLESYRVCPIAGYKLSHAWNTDFQVLPSTSTSDMPPTPTSTLKALSPPATLASAHTDTLLHWGCYPGTLLRIKMSKNHAVVLFVDEDDAPGVVCTSWIAETNDCCIYPNVKTNEARDRYLKEIHTPEDNWAICRIKILKYYRKFEFALRNSKHAEETSHLESETEEEPVLYTKRKIRERHIVLPGEENSEAAPKRRRILEMRTSLPSLPPFPKPLIHHRSESPSPTRSSSQSLQDSSPGIHESGWRSPSVSTGASTQMLITQLKLLNSKIGYFMSDVSQALTELKSEVKWIKERLSGGSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UD92</accession>
    <name>A0AAV6UD92_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000462">
        <property type="protein sequence ID" value="KAG8182442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UD92"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000051">
        <property type="entry name" value="Peripheral plasma membrane protein CASK isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="13936" checksum="16391BB78A5216F6" modified="2024-11-27" version="1">MNVMAEDEILFDDVYELREIIGKGPFSMVRRCVHRTTGQQFAVKVVDVAKFTSCPGLSTEDLKREATICHMLKHPHIVELLETYSSDGMLYMVFEYMEGSDLCYEIVKRAILGFAYSEAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDH3</accession>
    <name>A0AAV6UDH3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000460">
        <property type="protein sequence ID" value="KAG8182532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDH3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="304" mass="33779" checksum="3D330605180DEB98" modified="2024-11-27" version="1">MATISDTTLEFFSKATAEQWSYMFSKYKDALKAKAARRTKKGGPEELIRMDTWYQEELPKLIHSRKELYITHEELVQLTKWKLMREKFRPNLIDLVRINTEKAVLTHSKKAFKRLPNLGGAIAMLTCLKGVGPATASAILAAAFPDQAPFMADICMLSTPGVETMDYTVAEYLNYTLELKKKADYLNSLDPTQEWNPHKIELALWAHFVAGAVETTILADLPSSEGTTQEAKISNAKDTESNSREDSSATPEKPVAEKRPLSDEDDSVDTVDSFVSAGSSNDPSDFTASKNGNGHEPPTKKLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEC3</accession>
    <name>A0AAV6UEC3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine kinase</fullName>
            <ecNumber evidence="2">2.7.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_021720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.3" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000458">
        <property type="protein sequence ID" value="KAG8182582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEC3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004054">
        <property type="term" value="F:arginine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07932">
        <property type="entry name" value="arginine_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000006">
        <property type="entry name" value="Arginine kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.135.10:FF:000003">
        <property type="entry name" value="Three-domain arginine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="entry name" value="ATP:guanido phosphotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022415">
        <property type="entry name" value="ATP-guanido_PTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF38">
        <property type="entry name" value="ARGININE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="Guanido kinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00112">
        <property type="entry name" value="PHOSPHAGEN_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="12">
        <location>
            <begin position="43"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="13">
        <location>
            <begin position="153"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="156"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="314"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="343"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8182582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="390" mass="43896" checksum="C36C966735DF4FB0" modified="2024-11-27" version="1">MEHRSIAVALISATAAAVAVAYFYWSKRIGSSSKMVDQEVLDQLEAGFEKLQNAKNCKSLLKKHLTREIFDNLKNRKTAMGATLLDIIQSGVENLDSGVGVYAPDAESYTLFGELFNPIIEEYHVGFGPSDKHPARDFGNVNSLVNVDPKGEYVISTRVRCGRSLEGYPFNPCLTEQQYREMEEKVSSILSGMTGELKGTYYPLTGMDKATQQKLIDDHFLFKEGDRFLQAANACRYWPTGRGIFHNDNKTFLVWANEEDHLRIISMQKGGDLKQVFKRLTDAVNTIESRLPFSHDERLGFLTFCPTNLGTTIRASVHIKVPKLAKNYDQLEAIAGRYNLQVRGTRGEHTESEGGVYDISNKRRMGLTEFQAVKEMQDGILELIKMERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEL2</accession>
    <name>A0AAV6UEL2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000445">
        <property type="protein sequence ID" value="KAG8182850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEL2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="37221" checksum="D406D20E3E623306" modified="2024-11-27" version="1">MSRIRKRCWTIINRIGNFFRCNRNTEEENPHSESEDLSDTYLDHELLHQDLEQEQPNDTQVLKFDSFDSDIDYISSDYTNESTESFRLVTTTSDKYPYDEFQKVYISKGEDRDKVDGNEKECFEPRSEEMSNDFHGEIKTLVREESDDNGNPELKMKGPNSVVIVNGHEFDVQRTVLRRESIYFEEALAGPENKLLVLHINSEECQGCFNIAYSYLCAKAVNQEHLFGHLKSKPRTLLLKEEFLALWDTDIFDPNYTKIVAATKIQAAFRGYRTRKQLSNNEDPKIRKWYSNYSMTSVFESEIRKDIVGQTPRFEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF64</accession>
    <name>A0AAV6UF64_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000434">
        <property type="protein sequence ID" value="KAG8183060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF64"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="141" mass="15970" checksum="B7806ACC9608B97B" modified="2024-11-27" version="1">MLSLVDQNPVMEPTSQKLLNNNTQEAVELLGLSSSDSLDSPSFTNFQAPKLKRKVRFKKPFRSHSRQKAGRSTSPKPCQCDFGGGLRVVSCFVVLAVVCALLWYVMTLSTRIQELQAKFAAYYFYFHCSIARYLNFTMNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UH12</accession>
    <name>A0AAV6UH12_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_013038</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000420">
        <property type="protein sequence ID" value="KAG8183347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UH12"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF59">
        <property type="entry name" value="ADIPOKINETIC HORMONE RECEPTOR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="313"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8183347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="730" mass="83538" checksum="B31A0D1A5F8A38F2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UH27</accession>
    <name>A0AAV6UH27_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000410">
        <property type="protein sequence ID" value="KAG8183682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UH27"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="698" mass="81011" checksum="816C11954E329A7B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJI3</accession>
    <name>A0AAV6UJI3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like modifier-activating enzyme 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_006860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">E1-like enzyme which activates UFM1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000396">
        <property type="protein sequence ID" value="KAG8183933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJI3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071566">
        <property type="term" value="F:UFM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071569">
        <property type="term" value="P:protein ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000066">
        <property type="entry name" value="Putative ubiquitin-like modifier-activating enzyme 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF9">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="9">
        <location>
            <begin position="47"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8183933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="397" mass="44253" checksum="687CF71F9701863A" modified="2024-11-27" version="1">MSITEADLNLRIKQLEEELRLERAKKEHKPREKIEQISSEVVDSNPYSRLMALKRMGIVDNYETIRNYTVAVVGVGGVGSVTAEMLTRCGIGKLILFDYDKVELANMNRLFFQPHQAGLSKVDAAAKTLYDINPDVEFATHNYNITTVENFKHFMHTLQTEGGKNGGIPVDLVLSCVDNFEARMAINTACNELGLRWFESGVSENAVSGHIQFVKPGETACFGCAPPLIVASSIDEKTLKRDGVCAASLPTTMGVVAGFLVQNVLKYLLKFGKVSDYLGYNALEDFFPTMTLKPNPDCDDSLCRQRQREFNSRKRDEPKVVEKAEKEIVHEENDWGICVVSETAEVEEGGKSEEKSDLAQGLKLAYEKPPVIEDDDSNCVDVHEQSLEDLMSQLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULC6</accession>
    <name>A0AAV6ULC6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_002315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000372">
        <property type="protein sequence ID" value="KAG8184468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULC6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072">
        <property type="entry name" value="ENZYMATIC POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072:SF49">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="5">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8184468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7749" checksum="C39A43828BDDE9F1" modified="2024-11-27" version="1">MFILDTDASKEGIGAVLSQEVDGKERVIAYFSKSLSKPERNYCVTRKELLAIVKAVEHFHHYLYGDGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UM63</accession>
    <name>A0AAV6UM63_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000377">
        <property type="protein sequence ID" value="KAG8184321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UM63"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="10105" checksum="AB5C383554DA89CA" modified="2024-11-27" version="1">MLSVFIPKEIRPPFEQEKKSICRPIIFFDVPLGIRLHTAIFHTDLKWVGRVCFPTLVGGNTMESLRNPNVNPTEAMDSGDPREMNIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNI5</accession>
    <name>A0AAV6UNI5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_002022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000324">
        <property type="protein sequence ID" value="KAG8185796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNI5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8185796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10350" checksum="4C1F8FB7275CE37C" modified="2024-11-27" version="1">MAALRNVVCFCVYACLCTVSTVGAFALFHVHDEREELRENIRRVMTPLMALGVVLKLVFGDEFQAHHLHPHHPHPRALPLPHHPSQHLLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPF8</accession>
    <name>A0AAV6UPF8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_005427</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Zinc metalloprotease. Provoques deadhesion of endothelial cells from cell cultures, and also degradation of fibronectin, fibrinogen and gelatin in vitro. Its role in the venom is not fully understood but it might act as a spreading factor that facilitates diffusion of other venom toxins. Alternatively, it might be involved in the proteolytic processing of other venom toxins or it might play a role in extra-oral digestion of prey.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="JAFNEN010000314">
        <property type="protein sequence ID" value="KAG8186074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPF8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="11">
        <location>
            <begin position="116"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8186074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="315" mass="35511" checksum="F264505089B10F09" modified="2024-11-27" version="1">MQHSRWLAGRRGLTNRAWIFFATLLKVTLVQIVLVGCAYSLRFPRTRALIVILPNISTGAGVQFPPQWSEIQELFNNTDGLYPENDVEALLARNALYGQAMGDIIFVKASVGVFQAAVKDVGFRWPGYPGHGTIPYVIDDSLSEITDIIDKAIEQYHTKTCIRFTKRTTEKDYLRLFYGQGCSSYVGRIGGQQDVNLGSGCDFVGTVVHELGHAVGLYHEHQRSDRDDYIQVFIDNVQEGYESNFDITPVSEELIFNNFNEFSIMIYGEFAFSVDTGNLKTMEALNESITLKDPFTKPGLTNRDIETINNLYECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQF2</accession>
    <name>A0AAV6UQF2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000323">
        <property type="protein sequence ID" value="KAG8185843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQF2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="323" mass="36763" checksum="D1763F770C423556" modified="2024-11-27" version="1">MSRLKRNGPFGRSWTIVCDVTEAETLWSLLRLVDLDAPQLFLRPPKNISMYTHDGCSFTRILCYISTNCGNGTAIRESAEYIRSKIDYPFAMFSFDLDLGTNTHLNSSFLHTPDGELYKYNGEDYELIPLKSFEISQNKQVRKLSEATLWTGRLPSEVTDEGFIYLPSTEEGITNMTKDSGGKWMIYNSGSNMTRHDEFFLAMTSLYQEGIFVGLKASTAKDCGETPPMLSNTTSLQSCRFVRKGALIFCYTADSEDKKDVLRAATAIRSVIENECVMYYKTNSASIKGTYKHEGKRYATKYMHTVSGGFYERDHLNRFKMFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQH7</accession>
    <name>A0AAV6UQH7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_027642</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000291">
        <property type="protein sequence ID" value="KAG8186742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030159">
        <property type="term" value="F:signaling receptor complex adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039911">
        <property type="entry name" value="JIP3/JIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886:SF4">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886">
        <property type="entry name" value="JNK/SAPK-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="287"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="690"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8186742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1296" mass="143630" checksum="925D525EBDEE02C5" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URJ0</accession>
    <name>A0AAV6URJ0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_005860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000305">
        <property type="protein sequence ID" value="KAG8186328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URJ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000824">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF20">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043775822" description="RING-type domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8186328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="406" mass="45399" checksum="84103836635F5935" modified="2024-11-27" version="1">MFRSGFVVYLMLSICAVDASIEIFDKYGRKVETFPDREAPFDDDFVTMEGFMESATPPDACSSLAPPSFLTNFTMGRFVLINGSEDCGFMLKVRNAEKAGYDVAVIFDPFPAPFQFNIRTFPIPSYELNLQVVLISYGDGVIIRNNYLYNHSYEHNFLIKLRPNTPDITYYMYLFGAVIGVCFFVMLLFMMCLLIKCIQEKRRSRRNRLSSRQIKQIPTAKFTKGDQYDVCAICLEDYNEGDKLRILPCSHAYHSKCIDPWLMNNRRNCPLCKRKITFGDSGDESDSEDSELTSPAENTPLLSSPSNTRAATSWGTFVVAVERPNNGSGPSAMPSPFPHIGSASAPTNDDSENPFLSADDDMEGLLPPPVNSINGGVDNLAVVFNEEVNDDLSPSDQPSNRLFCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URJ2</accession>
    <name>A0AAV6URJ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_016170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000280">
        <property type="protein sequence ID" value="KAG8187072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URJ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="149"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8187072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="508" mass="57711" checksum="85556F89C40C697B" modified="2024-11-27" version="1">MKLYAANGTSIPTFGEKLLHVDLNLRRSLPWPFVIAAVSHPILGADFLKNFGLLVDMKNNRLIDTSTGRKVSAPVIALSYGTISLLAQDSKYKDLLSEFPEIIKVSNPVKINHQVEHHIETTGPPVFSRARRLTPEKLAIAKQEFQYMINQGICRPSKSSWASPLHMVPKKDGDWRPCGDYRRLNNVTKPDRYPIPHIHDVAQQLEGKTIFSTIDLFRAYHQIPVREEDIQKTAVITPFGLFEFPFMSFGLCNAAQTFQRFIHSILQDLDFCTAYIDDVLVSSKDEKEHMHHLRLIFQRFQEYGIRINPSKCNFGQPEVNFLGYRITAQGTQPMEDKVSAIVNFPKPSTVQEMRRFLAMNNFYRRFISRAAETQAPLFQFLKGAKKNDKRQIIWTEEAEKAFQQCKNDLATQPILAHPSSSATISLAVDASDSAIGGVLEQIAHHAAPVRYPSQQPSPLKPRFLPARVRPWESSSLSQVEEMPLLHLLTSKTTTLHPVGRNLIRRPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6US67</accession>
    <name>A0AAV6US67_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000281">
        <property type="protein sequence ID" value="KAG8187049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6US67"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="148" mass="16911" checksum="A37BAC68D680AA83" modified="2024-11-27" version="1">MHVNSPVFLPIRTYSFSDISLVTFHLGPFLSALSRPQLDCRLGALGPLLGEDSSDPRIELRGGGLNLCESKKAYDAKAEVWFRNFRDKNIEKPFLEIGGVWRSEDTKLCESIRMPAECLFLKVLQPAPWWKAHNQLDRLLMQASEQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTI6</accession>
    <name>A0AAV6UTI6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_009516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000272">
        <property type="protein sequence ID" value="KAG8187444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTI6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF154">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043473553" description="Ig-like domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="25"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="115"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="238"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="324"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8187444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="689" mass="77709" checksum="45C31802E11C7A76" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVV6</accession>
    <name>A0AAV6UVV6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000253">
        <property type="protein sequence ID" value="KAG8187959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVV6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="650" mass="74429" checksum="6B7501EF1E05449F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWF1</accession>
    <name>A0AAV6UWF1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_009882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000251">
        <property type="protein sequence ID" value="KAG8188003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWF1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040171">
        <property type="entry name" value="USBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019536">
        <property type="entry name" value="USHBP1_PDZ-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23347">
        <property type="entry name" value="COLORECTAL MUTANT CANCER PROTEIN MCC PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23347:SF6">
        <property type="entry name" value="FI17904P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10506">
        <property type="entry name" value="USHBP1_PDZ-bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="685"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="539"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="754"/>
            <end position="795"/>
        </location>
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    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="855"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8188003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="959" mass="108027" checksum="07DA4E7F616E4DB1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXG0</accession>
    <name>A0AAV6UXG0_9ARAC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000248">
        <property type="protein sequence ID" value="KAG8188156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXG0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="11691" checksum="A40911E140102E66" modified="2024-11-27" version="1">MTNHTQPQHGPESRTTIFRIHPSSPIFQIASAIDSAAPHSLYHNAPPHTALKGHPLKVRGGRALYYLEEVSYKMFMWSEDMGGRWCGRHLFSSSGRGVSSICKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYJ2</accession>
    <name>A0AAV6UYJ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_020225</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000216">
        <property type="protein sequence ID" value="KAG8189411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="CDD" id="cd05748">
        <property type="entry name" value="Ig_Titin_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000440">
        <property type="entry name" value="Bent, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000031">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002083">
        <property type="entry name" value="Protein CBR-UNC-22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000160">
        <property type="entry name" value="Titin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000003">
        <property type="entry name" value="Titin isoform E"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000127">
        <property type="entry name" value="titin isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000214">
        <property type="entry name" value="titin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000056">
        <property type="entry name" value="twitchin isoform X4"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000006">
        <property type="entry name" value="Uncharacterized protein, isoform F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000567">
        <property type="entry name" value="Uncharacterized protein, isoform G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000051">
        <property type="entry name" value="Uncharacterized protein, isoform J"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="258"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
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            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
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            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="963"/>
            <end position="1049"/>
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    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1155"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1256"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1452"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1553"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1752"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1851"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="1950"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="2047"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="2146"/>
            <end position="2241"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="2245"/>
            <end position="2335"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="2343"/>
            <end position="2438"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="2444"/>
            <end position="2539"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="2640"/>
            <end position="2733"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
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    </feature>
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            <end position="2927"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="2935"/>
            <end position="3028"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="3034"/>
            <end position="3129"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="3227"/>
            <end position="3321"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
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    </feature>
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        <location>
            <begin position="3426"/>
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        </location>
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    <feature type="domain" description="Fibronectin type-III" evidence="17">
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            <begin position="3523"/>
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        </location>
    </feature>
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        </location>
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        </location>
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    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="3817"/>
            <end position="3909"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="3916"/>
            <end position="4010"/>
        </location>
    </feature>
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        <location>
            <begin position="4014"/>
            <end position="4103"/>
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            <begin position="4111"/>
            <end position="4206"/>
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            <begin position="4212"/>
            <end position="4307"/>
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            <begin position="4311"/>
            <end position="4400"/>
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            <begin position="4407"/>
            <end position="4500"/>
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            <begin position="4506"/>
            <end position="4601"/>
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            <begin position="4605"/>
            <end position="4693"/>
        </location>
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            <begin position="4700"/>
            <end position="4793"/>
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    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="4800"/>
            <end position="4895"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="4994"/>
            <end position="5092"/>
        </location>
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            <end position="5193"/>
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            <end position="5286"/>
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            <end position="5388"/>
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            <end position="5489"/>
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            <end position="5590"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8189411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="5706" mass="632810" checksum="534C3410BDA782D6" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYK4</accession>
    <name>A0AAV6UYK4_9ARAC</name>
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        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_013782</name>
    </gene>
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        <name type="scientific">Oedothorax gibbosus</name>
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            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
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        </lineage>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="412" mass="46745" checksum="1B4CA9FDD5450A05" modified="2024-11-27" version="1">MYKNHTFPMEDGPIEDISIDMVDHCSFELNFSMYNFPNNASLTEPLTWSEYVKIALYVVVLVVALVGNISVILTVALNRSMRTTINLYLVNLAVADLFICLFCMWVPMVNSLTQPIYSLGEVFCKLNPFAQMTCLTSSVLTLCAISCDRFIAILFPLHVRITKQRTSGVLSAIWTVSGTVALPFLLVRKYNTYQWRDLSEPVCDDDWPLEERWDSDLGVCIRTYPMKQLYYTFVTVTLFFLPVAIMAVAYALIICRLWRTRAPGESNVANLNVQHRAKKKVIKMVCVVLVGFVACWSPLQVTVLYSEFVHSASQFGELPFWFGGFQYFSMFLAYFNSALNPVLYGGFNNNFRQGLCNVLQCAYAKQLRRPQFSQKSRTTHLSGSSTRVNGVGPVTRAIELHSIRETSHETNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYM0</accession>
    <name>A0AAV6UYM0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription cofactor vestigial-like protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000217">
        <property type="protein sequence ID" value="KAG8189337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYM0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001223">
        <property type="term" value="F:transcription coactivator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006627">
        <property type="entry name" value="TDU_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028184">
        <property type="entry name" value="VGLL4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17604:SF7">
        <property type="entry name" value="TONDU-DOMAIN-CONTAINING GROWTH INHIBITOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17604">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15245">
        <property type="entry name" value="VGLL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00711">
        <property type="entry name" value="TDU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34533" checksum="0856870332FD0C13" modified="2024-11-27" version="1">MDALDNREPSLKELPTRELKLKRHQVRRDSPTIAPVRLRLKNNNSPLNSESDFQKCFSDRSVSSSPESVTNEHSQIFMTSSCKSSPQMNSLPSSPLTIESNYDSHDDFNSTTPSNYIEHEDYDQPLDMSRKRPQEVILDSEITHRKQLRPSVITCASALLRTPCNLSDLAHQMCATNVSDYNSHEISNNQSCLKNPQGHITENTDSEDARPGHRREIVSGSCDPVIDEHFRRSLGKDYQHIFSKSTSSSVSITVDDHFAKALGDTWHQIQQSKSVTAESEPTNNTTKSLQPQQPPPYLQQPPEIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZR4</accession>
    <name>A0AAV6UZR4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_013731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000219">
        <property type="protein sequence ID" value="KAG8189197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZR4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051606">
        <property type="term" value="P:detection of stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421:SF29">
        <property type="entry name" value="GUSTATORY RECEPTOR 5A FOR TREHALOSE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8189197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32328" checksum="9184A5B0D66F3EFA" modified="2024-11-27" version="1">MFRLPTKSYQGIVQKEDVYIFILALLNGFLVSTIMVINILFLKQTHKARMDSQKFFGMVLSTDMRKYYMYTHYFLFVFTSTFSLVTQMFVSLLSFNTFLGLSKDIKKYRESLAKLVANNYKDEVCIHDYLVGFRRIVDCISGVEAGFSYTNLFLIGANVSSFFIFFSIAVSAENGYHQTAVAALITSVLLLSLIQFLSMVGTAARVCKEDDALKKLVIRCSEKAFSDFQGKVSLSKLHCFALLADTIRGTPLELTGGDMFVIKDNFILSVAGVMLTYGVLIFQFGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0T5</accession>
    <name>A0AAV6V0T5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000184">
        <property type="protein sequence ID" value="KAG8190425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0T5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10337" checksum="69946EC8DF3068B9" modified="2024-11-27" version="1">MQGERLNRLGSPDRYVSKVLRLLFQHQYSPALVHPQPPTHFRAEKTDRLVILSSGSEPSVRFRTPPFLPYHSTGLPDMSRDGVGGASGFRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V219</accession>
    <name>A0AAV6V219_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_009081</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000199">
        <property type="protein sequence ID" value="KAG8189941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V219"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.530">
        <property type="entry name" value="DNA polymerase alpha-primase, subunit B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043034">
        <property type="entry name" value="DNA_pol_alpha_B_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013627">
        <property type="entry name" value="Pol_alpha_B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08418">
        <property type="entry name" value="Pol_alpha_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="10">
        <location>
            <begin position="198"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="321"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8189941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="573" mass="64248" checksum="4A9C6D44A55CCAEA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V461</accession>
    <name>A0AAV6V461_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor-like protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_021167</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000157">
        <property type="protein sequence ID" value="KAG8191562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V461"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04157">
        <property type="entry name" value="Arl6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000457">
        <property type="entry name" value="ADP-ribosylation factor-like protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041839">
        <property type="entry name" value="Arl6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 16 18" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="9 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8191562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="189" mass="21448" checksum="77C814B160D69E64" modified="2024-11-27" version="1">MGLFDKLAYFLGIKKREANVLIVGLDNSGKTTIINHFKPEEQKSMEIVPTVGFNVDRFKMKSLSFTAFDMSGQGRYRNLWEHYYPEAQGVIFVIDSSDALRMVVAKDELEMMLQHKDIKDRSIPVLFFANKMDMREALSSVKVSQALGLDRLKNKPWHICASNALTGEGLGEGVEWLSDQLRSSVLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V464</accession>
    <name>A0AAV6V464_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000162">
        <property type="protein sequence ID" value="KAG8191284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V464"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="348" mass="41031" checksum="8AD9173DB0A43FE1" modified="2024-11-27" version="1">MDDQGSSWTSPTKSVPWPPPRHRVSELRKKFERSPKKKYHPQEERYNQDQFQNQEEIQYQEDGYNQEENDWQRYIDDYQNDFDPNERYSNQDAYHESYRDEFQEPSFANVSEFKTTGYHEGRSHTGHKESPINESSDEEVRSPRARIPHHSKVPGLIYSTDEESSDEQEIRRRKNDPSRRHDPGHLALIYSSDEEEELAKEEANRRYRELFRKFYPNDDTTFPESVQRRETPDYPPEDHLESQDKPVPGSSSRRASQNNGAGNVTEVPPQPAIERRGLLGSPDENLWRGIRDMKDSVLQPKRLQKPKKYIEFAFEKGFLYPPTIKFIIRLGVPLIQPTINILPPVNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9X5</accession>
    <name>A0AAV6V9X5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9X5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9918" checksum="ADF03A788CF26637" modified="2024-11-27" version="1">MVQGLNSNPAHPMHLTNTNTLTIKPRLLPPNHHKLCPVPIRFRVHQSGRPRPTEDTGRSRQFTDLGFWDEQCLSGPVSPFVIWRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VA03</accession>
    <name>A0AAV6VA03_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000132">
        <property type="protein sequence ID" value="KAG8192938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VA03"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="7995" checksum="2E70AAE42855F877" modified="2024-11-27" version="1">MFHPFWAVRGNHHANAVVTSARNHARSRGSSSMAFCRRMHLELCSLISEIPMEGSSKTALSGSSLFEITFEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VB24</accession>
    <name>A0AAV6VB24_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="9">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_029563</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="9"/>
    <dbReference type="EMBL" id="JAFNEN010000114">
        <property type="protein sequence ID" value="KAG8193829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VB24"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000001">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8193829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="439" mass="50119" checksum="54C8398DD529B658" modified="2024-11-27" version="1">MKNEFTLCVKRFFQINRTLKMSKLTTAILPNLRRNLLKINHLSNRSNGSYYSQISNNAAKENKILDYLRAKIEATGPISVADYMKEALISPCSGYYMSRDVFGTSGDFITSPEISQIFGELIGIWYFNEWSRIGQPQPLQLVEFGPGRGTLTDDILRVFSKLTSPSQYKLSVHFIEVSPHLRQVQMSRLCPENLNESSYDKSFITKYGFPITWHPHLTTVPEAFSLYLAHEFFDAMPIHKFQKTQDGWREILIDFKDNELRYIISRNPTAASKVLIDEKEERDHIEVSPESGILLESILKRIEEDGGIALIADYGHMGTKTDTFRAFKEHKLHDPLKNPGEVDLTADVDFKYFSELAKNKAVVVGPVSQASFLKNMGADIRLEKLMQFADAANQKSLKTGYEMLTSPDQMGERFKFLALYPTILEDFLTKYPPAGFDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VC40</accession>
    <name>A0AAV6VC40_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_003022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000109">
        <property type="protein sequence ID" value="KAG8194077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VC40"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="160"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8194077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="197" mass="22137" checksum="2FFD30310C68AD24" modified="2024-11-27" version="1">MFALQRIQRELKDIFQNKEASQRMFKLDMVMDSLLELRGEIAGPSGTPYEGGLFVLKIKVPQTYPFTPPEISFVTKVWHPNISSVTGVICLDILKDQWAGSMTLRTVLMSLQILLATPEPDDPQDATVAKQCIENPEMFELTAKHWTQVYAGAPKTPSDFDAKIKILLNMGVEENKARDALSCCSWNLQEAIDALFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDY2</accession>
    <name>A0AAV6VDY2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA ligase</fullName>
            <ecNumber evidence="19">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">JTE90_021375</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="19"/>
    <dbReference type="EMBL" id="JAFNEN010000096">
        <property type="protein sequence ID" value="KAG8194914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDY2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070421">
        <property type="term" value="C:DNA ligase III-XRCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07967">
        <property type="entry name" value="OBF_DNA_ligase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000085">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000003">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031916">
        <property type="entry name" value="LIG3_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16759">
        <property type="entry name" value="LIG3_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00347">
        <property type="entry name" value="ZF_PARP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="22">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="23">
        <location>
            <begin position="468"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="24">
        <location>
            <begin position="871"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="101"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="725"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="731"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="745"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="761"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="826"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG8194914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="957" mass="108673" checksum="CE1D684248378509" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VE90</accession>
    <name>A0AAV6VE90_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_008184</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the VPS35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000095">
        <property type="protein sequence ID" value="KAG8195012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VE90"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031748">
        <property type="term" value="F:D1 dopamine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099639">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099175">
        <property type="term" value="P:regulation of postsynapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.660:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8195012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="781" mass="89616" checksum="694BB936A6C31931" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEF1</accession>
    <name>A0AAV6VEF1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000094">
        <property type="protein sequence ID" value="KAG8195072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEF1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="9061" checksum="661FD65584888A37" modified="2024-11-27" version="1">MIPASTICNSFGFFYESFDVKLSTILTHPLHKPVNEVSHHFPVNPTLTFPNDQTTRIPEINNRDINSCEFKPEETEPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGP9</accession>
    <name>A0AAV6VGP9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_017220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000098">
        <property type="protein sequence ID" value="KAG8194778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGP9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000327">
        <property type="entry name" value="ATP-binding cassette sub-family A member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="381"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8194778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="677" mass="75526" checksum="C6D2D1F450AA4DFB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHZ2</accession>
    <name>A0AAV6VHZ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_002207</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000084">
        <property type="protein sequence ID" value="KAG8195587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060429">
        <property type="term" value="P:epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000100">
        <property type="entry name" value="protocadherin Fat 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF93">
        <property type="entry name" value="CADHERIN-99C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043417346" description="Cadherin domain-containing protein" evidence="14">
        <location>
            <begin position="26"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1309"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="133"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="260"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="370"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="504"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="591"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="691"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="793"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="894"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1005"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1124"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1426"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1426"/>
            <end position="1452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8195587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1513" mass="164028" checksum="46E851E89371575B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJY4</accession>
    <name>A0AAV6VJY4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJY4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="9042" checksum="0D03E7D5AC60D18A" modified="2024-11-27" version="1">MQNVPQQNLKKRGLLKRSRALTMETEDRIGLFKTSLKSLPEYESVGLDPTDLAAEEVRPFPSIPDRMLKHLGLFGVFVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKI8</accession>
    <name>A0AAV6VKI8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Scavenger receptor class B member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">SR-BI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_003581</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Caveola</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000068">
        <property type="protein sequence ID" value="KAG8196568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKI8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF110">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8196568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="527" mass="59894" checksum="CF4A43ED60D2A19F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKN5</accession>
    <name>A0AAV6VKN5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_013493</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000056">
        <property type="protein sequence ID" value="KAG8197367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKN5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF352">
        <property type="entry name" value="BCDNA.GH04802-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="125"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="279"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8197367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="384" mass="43073" checksum="95781B5934C8FA3E" modified="2024-11-27" version="1">MALERKRSSRRPPPRRSVRPQENKCRRCCRKFTAFMFSHVGLCALVVGYSILGAFCFQALEAEHGEQTTSDVQQRRADAVRRLWAITDQLNVLYKDNWTRQVREEVRSFQSDLVHAIREGYDGKEGAGTQWTFSGAFLYSLTVITTIGYGNIAPRTPSGKIATVFYAIVGIPLMLLYLTNIGDILAKAFRYLYSRACNACDAGRRVRRTDAYRVQHAVATLSRGVDEEEEKYRRMGMQPPMTREDEIRIEPIPEMSSEVGGGSTKSSRVSVPITLCMVILVSYISGGAVLFSLWEGWNFLDGSYFCFVTLSTIGFGDLVPGDSVISEGGSQEKLVMCSLYLLFGMALIAMCFNLMQEEVIHKVRTCGRRIGILKDTEAEDDDMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNG3</accession>
    <name>A0AAV6VNG3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_001850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000045">
        <property type="protein sequence ID" value="KAG8198010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNG3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="241"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8198010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="342" mass="37184" checksum="943FD06CDFF154B0" modified="2024-11-27" version="1">MNGYVGRQKWLIAINRSDLSEEKMTWLKVCQEHFVTGMPAHLEDVQHTDWVPSKNLGYGKDVSATSYSRYQRAKNRSKVPLSSGSISNLNDDAAASFDGDAAASFDGDAAASFDGDAVAPLDAEAVARLDAEAVAPPDAEAVAPLDAEAVAPPDDEAVAPPDDDTVAPPYDDGVAPLDDDGVAPLDEGAVIVLRDNTKRGRTISVQTETTMQDLIALQLSYDAAVSELTEVKERLRKMSLNRGFNVKDEVELYCAEIKVPAFTKGKKQLSPLDIENTRALAHVRIHVERVIGVLRQKYRILHDIMPISLIKKTTKDAPSTVDQIVYVCCCLTNMCPSVVPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNL1</accession>
    <name>A0AAV6VNL1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNL1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="185" mass="20773" checksum="DA216F13E652A40D" modified="2024-11-27" version="1">MKTLLELFNENGHVAALSADRAKQFDSVCYKSATEFKESFQTNTRETRLDDFYITLIGKDKEFRDLINVIKMVLTFSHGNASVESGFSINKDMLVENLHETSLIALRTVYDGVKSNGGIENVKIIEELMNHSRIILKMNTSHKTLSVVSDLKRLYRLHHNTCIVDGQGSIPGTSKRCVASALVMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQF7</accession>
    <name>A0AAV6VQF7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQF7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF9">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="342" mass="39121" checksum="3DB7305A93795E16" modified="2024-11-27" version="1">MSLTIDYFKQLHYDFIPKGSYIQDKMKTILYTSFLVVILQYVTSINAVTQSELIHHVEADPELEAYLREAIENFREQMKEGIDAIQMPILDPLELSQLNINVRENLATLDLHIKTITVEGLSSFTFHDIYPDLESYFLKVNLTIPSVESWGTYDLNGKLLKIFPLKGNGNFQINITQAEIVGLTVQCLSIFKLTHLKPNLEEMYLGINLTLPEIYMSGNYSVNGKLVKILPIYGDGSFYMNATDIKISGFGQLAFTNETIQMSLLKLDLHWEHLAVNMENFLGGGSFAKVLQQVVPKVGRDIFYGYKPLIMEKLEKFMQEMVNEKLEEECVKDIIKVIIPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQH0</accession>
    <name>A0AAV6VQH0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_015088</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000034">
        <property type="protein sequence ID" value="KAG8198874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQH0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20024">
        <property type="entry name" value="FH_FOXJ2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF2">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8198874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="445" mass="49524" checksum="98645ECD4EAC664B" modified="2024-11-27" version="1">MGDLDRSLTSMDWLPRLNVRGPVNGANAHDGNSISCENSRNCRQKDGKPPYSYATLISYAINSSTSKKMTLNEIYNWICSNFPYYREAGDGWKNSIRHNLSLNKYFRKVPRPKDDPGKGSYWAIDHTPSEVDDCRRRKCRQRDKVFPYSPDNSSSNSLSSPVHCHQMTASCSQPNQQMTAHMNPERTNMVNSHPAFQEMGHASGHMMASDSVSSCCNHNPQQFNMNTSQAQDTERLSSSNFVQGLDWLRENAKMPGNGSVQDNDISHYPMNDKISAEHFVQSLDWLRESAKMSGNGLQDIDMSHFQTMMENIKARDPSMSLLSQDQLADLNSSLNALFSQSGVLQPASSPAASADTMQPCYGSQQVNTTYSRESCMHSSAPNSNNSPHNISAESSNLSYHSQAESSPLPLPSHVSLNSSVHTTPGSQTGDDNDEIEDDFNWDKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQQ7</accession>
    <name>A0AAV6VQQ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase kinase kinase kinase</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_015295</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="EMBL" id="JAFNEN010000042">
        <property type="protein sequence ID" value="KAG8198197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQQ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06613">
        <property type="entry name" value="STKc_MAP4K3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000031">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021160">
        <property type="entry name" value="MAPKKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF18">
        <property type="entry name" value="HAPPYHOUR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038172">
        <property type="entry name" value="MAPKKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="15">
        <location>
            <begin position="584"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="491"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="491"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="24"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038172-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038172-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8198197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="926" mass="104880" checksum="9A2F10CDF177ACBA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRV0</accession>
    <name>A0AAV6VRV0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_011829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000028">
        <property type="protein sequence ID" value="KAG8199369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRV0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF9">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8199369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="224" mass="25057" checksum="F662B47056D09418" modified="2024-11-27" version="1">MEVFQNYEDQEIDMYLDLHAHTGLLGTFVYGNSYTDVYRFQRHSLFPKHLSYCAPDFSLEHTAYNKDRNKQGTSRRFLSSFLDEKVNCYTLEVSFHGYEVPKGNSSTAIHVYDEAEYLRLGESICHSLLDYYCATKYIPPEEVPPSVRESCCKGSRANKLQQQQQSSNQSSSPHHVAAASGMTGNVKKSATAKGKAAKTKPAATSKTSEEPHAQKPKVASAKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRY3</accession>
    <name>A0AAV6VRY3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FAM133B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_009466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRY3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026766">
        <property type="entry name" value="Fam133"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31911:SF1">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 133 MEMBER B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31911">
        <property type="entry name" value="PROTEIN FAM133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8199632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17932" checksum="80BF00D5F6B613D5" modified="2024-11-27" version="1">MGKRDTRYAYMNPIAMARARGPVSSGGPSMRDYMNRERPSWEEVKEILRKKKQGSSTLAAWEDRMNEKFRKELKRNREKLLKENSSDKKKLKKKRSSSSSPRLSENTSEKSAHSSKHKHKKSKRKRDHSDKEEDCLDSVSTKLAKKNKHKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS21</accession>
    <name>A0AAV6VS21_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="8">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_015117</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="8"/>
    <dbReference type="EMBL" id="JAFNEN010000034">
        <property type="protein sequence ID" value="KAG8198905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057493">
        <property type="entry name" value="PH_RdRP-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25359">
        <property type="entry name" value="PH_met_RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH-like" evidence="10">
        <location>
            <begin position="152"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="9">
        <location>
            <begin position="487"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP C-terminal head" evidence="11">
        <location>
            <begin position="1075"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8198905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1485" mass="170802" checksum="5BB83AD4B4EEB37F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS77</accession>
    <name>A0AAV6VS77_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_009378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VS77"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042869">
        <property type="entry name" value="ARHGAP11A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15670">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15670:SF4">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="60"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8199537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1176" mass="131430" checksum="E03BDADDA661A9FB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSA3</accession>
    <name>A0AAV6VSA3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_000259</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSA3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF159">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 74D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="620"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="812"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="827"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8199390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="840" mass="91447" checksum="39BBB3AED9566624" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSJ9</accession>
    <name>A0AAV6VSJ9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000025">
        <property type="protein sequence ID" value="KAG8199657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSJ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8080" checksum="6F890D86EEB974EA" modified="2024-11-27" version="1">MSSKTASRYLAIFPSHRSVKPAAKTFARPSATFSTAEPFFSPLPLTILDLVSEDFTYTCVDTGEIDRRTFVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTD2</accession>
    <name>A0AAV6VTD2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase III subunit RPC8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA-directed RNA polymerase III subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">DNA-directed RNA polymerase III subunit rpc8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_009370</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With CRCP/RPC9 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination. Interacts with CRCP/RPC9. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTD2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000130">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004519">
        <property type="entry name" value="RNAP_E/RPC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00448">
        <property type="entry name" value="rpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="14">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="15">
        <location>
            <begin position="77"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8199528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="195" mass="22485" checksum="FEFAEF2B8F7043D4" modified="2024-11-27" version="1">MKDIIRIPPSKFRKPLTEAVAEELRLKFANKIVKDVGLCIALFEITKLEDSYIFPGDGASHTGVFFSYVVFRPFMNEVLVGKIRSCSREGVHVSLGFFDDILIPKDELQHPSRFDEKEQLWVWVFSSEESGQSHDLFMDRDEPIRFRVLEGTFVDTTPTCPEMETAETEEKERRIPYYITGSINQPGLGLLSWWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUB6</accession>
    <name>A0AAV6VUB6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_000605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUB6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="20"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8200532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="573" mass="63460" checksum="E5E67EA3AF08E2A1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYJ9</accession>
    <name>A0AAV6VYJ9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYJ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8202107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="115" mass="13133" checksum="8944B374CEC6B6D1" modified="2024-11-27" version="1">MHSLRKPSNLHPGFLDLTKQYKKIICQKIISDVPSLLQDYLLKKVPEVTTVTVPPELEALFGKNSNKMCGVSPSDIDKYSRLLFPVCFVSFNMMYWIIYLHISDTLGEDNVALQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYT0</accession>
    <name>A0AAV6VYT0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_020523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000011">
        <property type="protein sequence ID" value="KAG8200883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYT0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8200883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="195" mass="22178" checksum="C36E520FDC73330E" modified="2024-11-27" version="1">MEQAVFLQGRAKDGKCLLRDGYLFRIGKRTPKKSYYTCLVSKCSSTVCLDPDEKMVLSSNGIEHNHAANPAEIEVRKFHQKLRQNILDQPNTAIPQLYKETLSSIHASSEVLSQIPTFSGIKNYMYKVRASVRPPLPKTMEELQLDGIWSKTTDGSDFLMVDEGIGDNRIMIFCTLENLKLLCSGKNYLWMEPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEE3</accession>
    <name>A0AAV6TEE3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005912">
        <property type="protein sequence ID" value="KAG8158689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEE3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8158689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="212" mass="22578" checksum="E092567F13C5A044" modified="2024-11-27" version="1" fragment="single">SYQGNFGTSPWSTLGRNKADDSGPFAAAKGLGPQQRTGPQNNGPFQGSLTSLRGEQHFPQGLGRRISQNGVIPGGFPFPFFLKSSPSGGGEIHYAAGLATLQDPAPQQEGVGEDIELDNLFTHRTSLTDQTGSGGGPTAEENQNVRVCANEYSNNFFIAEYNAGRAQTTLRNKSSRPQSSYSNDGTGTVPSRNNPAKQKRKEGETNETTTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEK0</accession>
    <name>A0AAV6TEK0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005865">
        <property type="protein sequence ID" value="KAG8159483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEK0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8159483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="156" mass="16956" checksum="F0C265484A88730A" modified="2024-11-27" version="1" fragment="single">SVLKVLTLVFATTTKIFTGGGSRRAPPPGTFPKHATAPSHSLRGKPPRGKLCRAARYGAQSWSAFPFSGVVFLWSVVCYTPLSEFRFPGPLVRLSRATNPFLWGLMSVSHRTPLNPGPLVLSHSASSAYQKWPPALSSCLVRLQSCKGDFSPIFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFL4</accession>
    <name>A0AAV6TFL4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005173">
        <property type="protein sequence ID" value="KAG8170589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFL4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="117" mass="14630" checksum="18DCEFDD361D8948" modified="2024-11-27" version="1">MKLKTRSRTQLKKYETENELKKYETENELKKYETENELKKYETENELKKYETENELKKYETENELKKYETENELKKYETENELKKYETENELKKYETENELKKYETENEIQNPAQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGT0</accession>
    <name>A0AAV6TGT0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004555">
        <property type="protein sequence ID" value="KAG8171024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGT0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="156" mass="16659" checksum="05C2C52CF27526AC" modified="2024-11-27" version="1">MGLAPTLGNSPGQGDLLQSPSPARSLLNATFPHALASGGFGAGLLPVHSPLLRESLLVSFPPLIYMLKFSGLSHGSRLTTSRAAYCSGARKQQGKKDDKRVELATRTAFNSHPPAARCYDHNMHHIPTEIISAMERHGTGAGPLAEKLRREGSRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJQ2</accession>
    <name>A0AAV6TJQ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003163">
        <property type="protein sequence ID" value="KAG8172069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJQ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8562" checksum="98F8E6C5025FD21E" modified="2024-11-27" version="1" fragment="single">MDLYAGYISNREEPVYAMLAAVSIGAIFTGDLPFLGSQAVINKLKQVNPKILLTIDRFMYNRQEINLLDNIKEIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJR8</accession>
    <name>A0AAV6TJR8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003487">
        <property type="protein sequence ID" value="KAG8171843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJR8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="253" mass="27918" checksum="EDB3B7329348D2C4" modified="2024-11-27" version="1">MGTTVTKIHYLPGFSRPPEAQPDTPQKETRVLFNENSVPISGRSPISRDTNSYKEKITLPRVLLSKTSPSSVGVLPREEHLVPKDLSPFRVWGYYPFFLSVRAARHTRACVCGFSADGPSLRNGFLLPILGPTTHVQTAVHMATLLQLHPSGFSLEVFATTTDLHRWRLPGGSRPAPSTHAPRPSYSLRRKNPTTREALPSGPGKGPQRWSVHPFSWLVASVGEFVYTLLSEFPTSMAIVRLSEQPPLSMGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKB3</accession>
    <name>A0AAV6TKB3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitinyl hydrolase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002894">
        <property type="protein sequence ID" value="KAG8172279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKB3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40452" checksum="3A80D7EBE5B273F1" modified="2024-11-27" version="1" fragment="single">LDDADEPRSEVSVLFEEESLGITEEEAWLYDDDDELFMENPLPEQIGDGIAPPDVNQMDTLVKASGFWDRIPVVGPVSLDRAIILQERSRRVIRRYDGEETTYFALIDPTMLPESAQDSTLGNSIEVVRMLFERLLVQTTRNLSPHDLIRIILEDDTLDRPISTFIMKVSDMSVDAIMNAVPKVLQSKDEIKLDAGFSVNVSIIRRPRGGGRNRRMVNPEVDRLKKGSVLTITKDDSGLCCSSAILLGLAVHNTDPELRTLKNQSCDLLKRRAIQLHSQTGVPEGPCGFTEVAIFERHLNVQVVIISTENMNQVVYKGAERPKKVYLWFNNNHYDLIRSPKGFYATNEYCEECVVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLD8</accession>
    <name>A0AAV6TLD8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002657">
        <property type="protein sequence ID" value="KAG8172483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLD8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="102" mass="11205" checksum="953932DF4FDEE24B" modified="2024-11-27" version="1">MFTEPPSVTVSGNEASCRRSLVNESTRDEEADDDRLSDTLRKYVFKDVTHSQMGNKRRPCGGKRPRNTARRPPPRNKGGAGHQTTHGIAVPTGKEATTTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLU0</accession>
    <name>A0AAV6TLU0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002698">
        <property type="protein sequence ID" value="KAG8172441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLU0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="65063" checksum="5D010F5FE0E570CE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNR6</accession>
    <name>A0AAV6TNR6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_020249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001954">
        <property type="protein sequence ID" value="KAG8173249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNR6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000400">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8173249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="476" mass="53280" checksum="0B4D5248910C4BA4" modified="2024-11-27" version="1" fragment="single">VRFGEVGGNTLGFFGSVFGPSGESVLAHGHQGAIHVWTHNEAKDSWLPGLSFGGHYSAVEDLDWDPDGQFVLSCSADQTTRLHAPYVTEDSKNSWYEIARPQVHGYDMVCLTVLNRFKFVSAGDEKVLRVFEAPRSFAETLKNLTKLDSSAYLKNSLVEGASVPSLGLSNKAVFSEDIIKSVSIEDEESQKHPKDRYPDFYYTPTLLTAPPTEETLLQNTLWPETQKLYGHPYEVFTVTSNHAGTIVASACKASKLEHAGIILWDTTTWKQIDYLTFHALTVTQLEFSPNDEYLLSVSRDRMWALYRYSPGEMPLYKKIANLDKKSNVHTRIIWSCSWSFDSLYFCTSSRDKKVAVWGQKAPQGDEPSEFSLCLQPLEVEDSASAVSFAPRLVDKKYLIAIGLENGSIVLSLWCCKDSWNVLTKLDQTIAHHLNINRLRFSPVTGEAGCNKKDANVLQLASCSNDHHVKIYDICVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNV9</accession>
    <name>A0AAV6TNV9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_009855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001909">
        <property type="protein sequence ID" value="KAG8173282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNV9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF45">
        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043361237" description="Kazal-like domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="124"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="181"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8173282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="218" mass="24174" checksum="019C00B209327D9C" modified="2024-11-27" version="1" fragment="single">MHSLAAIVVLCFGCCTGFAVGQLRDPDLFEPVLDYDILPGLESTDYVRVRDDRERRFLAGLVIEAGRHTLFPELYSPEAPREVAAVATSQEGLDQEESNPFDVLDTKPGPIKFYETSGQPELEESYLNRLNRRGRVECPEECPVYKPVCGSDGKVYTSECQLRKENCGSAPVSAGPWSKCHGKHYLCPTRCLDISDPVCASDGRVYSNVCVMRKNNCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPC0</accession>
    <name>A0AAV6TPC0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001540">
        <property type="protein sequence ID" value="KAG8173695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPC0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="2">
        <location>
            <begin position="153"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8173695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="277" mass="29942" checksum="C7758B6CBFB6155D" modified="2024-11-27" version="1" fragment="single">MLLLQSNVQPPFKVLNLLSKFSTSALTSVSESHLSSEESCNSSTAEAVFESPDSLNRGCVSFGLLSGCVSMTTTVGEGTLRPLGYFDYIKREGMSSTSSSRNGAEKPDTTNEENGPAPDSQGESSAEKAKYNQLIDAFNLLQAKMAACGHSLDPKLPKIVVIGPENSGKTSVLQSFVGKDFLPSGSGLVTRRPTVIQFEPLPKGSVEYGVFAHMTQSNDNTETKIYDFAAIRQEILDETNRKLKPTEFSSEPIVLKIYSPNVLKLTLVDLPGMVQCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQ70</accession>
    <name>A0AAV6TQ70_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001374">
        <property type="protein sequence ID" value="KAG8173992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQ70"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043552003" evidence="1">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="260" mass="29630" checksum="1D00B21ADCCF0710" modified="2024-11-27" version="1">MKNFLFAIVFAVVVGSQAYEEELKCNFRICGSELLNFHDYSISSIFKKIEYSSFCIKNCTPPVVHEFFQSIRYALTKRIPGHCAGHDCASKNRFVALSKCVHEKAWPLLQCSKDSWILPKWHSEVKEMQTKRNYTCSITVESTQCIEEILQECGTYPFTLAKDIFIDVVKQGISAYCPRNKLTNDFFIEHMTTTLAPYQDRLKTFTDISPAPGDRPYPQFVKGYRIKRDGDPDDNGAPTQSVSLACVAAGLVLSLYMNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TR37</accession>
    <name>A0AAV6TR37_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bardet-Biedl syndrome 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_010761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the BBS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001330">
        <property type="protein sequence ID" value="KAG8174086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TR37"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186:SF1">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8174086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16932" checksum="C68E25A7AFE72899" modified="2024-11-27" version="1">MDSEAGPSRNMPNENAVSKSQEESKPIAIEASKILPPNKKGIAKKPPDLPTLERRNWLIHLHFTRKEYETCKIIIKEQLDETQGMCEYALYIQALILRHEGRIQESLELFQTCSILNTSAENLKQVARSLYLLGRHKNAIDVYEEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRE0</accession>
    <name>A0AAV6TRE0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_015747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001204">
        <property type="protein sequence ID" value="KAG8174475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRE0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BESS" evidence="3">
        <location>
            <begin position="122"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8174475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="167" mass="18947" checksum="724BC8EB26CA53CC" modified="2024-11-27" version="1">MRCLSFLDNYSLARSTYSNFPGNNKGGLSNESLAARERTSTQAAGEGTSTQDTEEGTSTQDEELTPAQDEEWTPTRQTTEPQPKRVCLEKKKNMQKDQFLKDLNDSRAERSAMLKELLNKERDPMDAFFESVTATVKTFPPHLQIRAKRKVTDVILDLEEENLLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRR4</accession>
    <name>A0AAV6TRR4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001255">
        <property type="protein sequence ID" value="KAG8174311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRR4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040391">
        <property type="entry name" value="BEND5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628:SF1">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="9653" checksum="49853B9EC9B25318" modified="2024-11-27" version="1">MAKKVKAGETGDSLYIKNLAVVVGGKQELANRSVCGFRCNTKKVCCQTNSERISAEGAGAAEIEKRMSKMNKFICEKIITINRNKNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TX23</accession>
    <name>A0AAV6TX23_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_008127</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000906">
        <property type="protein sequence ID" value="KAG8176223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TX23"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="8" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="9" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043989315" evidence="11">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8176223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="121" mass="13175" checksum="1ABA81D494B236B3" modified="2024-11-27" version="1">MAPRINIFLLLISAAYCGSLADGHILLELTPGECYEMVRLATAGDQVDMVELLASHGCSVNRPPGSTSRQSTPLHIAAVSGYLDMVDKLLDYGADVHARARPSKELFKKKCATCKYLLKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXQ2</accession>
    <name>A0AAV6TXQ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000862">
        <property type="protein sequence ID" value="KAG8176624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXQ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558:SF1">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="309" mass="35978" checksum="500904A5DAB2AE56" modified="2024-11-27" version="1">MQDNRNRWSCFDDICLLKGVVAENPFNDAEKWKLVQQSVELATQKSYSVRACRDHLNHLLKKFITEDRANLRKSGTEEEYSTKEQLLQHVKDLKLEFAEERKRQEKKKTSEKGSREAAVVARYQAAYSIQCSENVDLVVDEELDASSVLETSLTEELQSSDCASPVRVPPSTADASAGVLMPTPGPSSQLDTPHLLRSAGGQKRKANLAYEFIKKKTHENTLQIKELELKEKQIELKRKKLELEEQKERNKEEQFKKQIELQERRLAFEEEERRERLIRDKENEKNLCNMVQMTFEMMKHMTEMITNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXV1</accession>
    <name>A0AAV6TXV1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_015418</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000837">
        <property type="protein sequence ID" value="KAG8176952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXV1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003090">
        <property type="entry name" value="Alpha-crystallin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF403">
        <property type="entry name" value="CYTOCHROME P450 306A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00525">
        <property type="entry name" value="Crystallin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="8">
        <location>
            <begin position="56"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="704"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8176952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="754" mass="85710" checksum="456AE292905A3143" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYV7</accession>
    <name>A0AAV6TYV7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000834">
        <property type="protein sequence ID" value="KAG8176969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYV7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953:SF1">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="31711" checksum="6D66119C0F5AB8A2" modified="2024-11-27" version="1">MMVGDFFKSSPDFCSAEFRNVKTSASSRQSYGDEAIGYVQLKKESGLCTVKCRICPEHKVTTKSYSVTMVVNEMEGLVKKIECHDCTASEGCCKHAIAFLMWVHRRSEEPSCTSVECYWKKSKLSKVGRSLKITTAKELSKSRPTLKPNSLQTSVLEKFLEEGNKRKLECQILKHQPSYDHQSYSLHQLTIQLKGCKDAEEFLCRTSAMYDVKKIRQMELETRNQSENPEFEKTNTVTITEVQYNDIYVRDVLQKIEEFWRKYIFPLLVRNTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U085</accession>
    <name>A0AAV6U085_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000748">
        <property type="protein sequence ID" value="KAG8177817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U085"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="118" mass="13004" checksum="CC3B16CCEF523675" modified="2024-11-27" version="1">MLPKRTLAVDQSENVRELKCILHLDSISDDVSSEEEEPKSSYIPPPKPPASPEVNGIEALTLHLPFPSEGFQQLPSVTVQQLPHDLSFVTETSKRKGTPSQSLGRPVALEEEDTSGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0B1</accession>
    <name>A0AAV6U0B1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000744">
        <property type="protein sequence ID" value="KAG8177847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0B1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="101" mass="11659" checksum="5F3AD2B374027A53" modified="2024-11-27" version="1">MHRCGSEVQISPNNIQNFLTIIDHAIFQPKLGYNYPVKDESDMVLLLLLLKNLVISILSASQYRSSETEVGRESIMLMLLKNARVWRWERAKGCFFGQTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0Q0</accession>
    <name>A0AAV6U0Q0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase theta</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_026190</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000773">
        <property type="protein sequence ID" value="KAG8177561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097681">
        <property type="term" value="P:double-strand break repair via alternative nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08638">
        <property type="entry name" value="DNA_pol_A_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000002">
        <property type="entry name" value="DNA polymerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.20:FF:000001">
        <property type="entry name" value="DNA polymerase theta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA polymerase theta"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="helicase POLQ-like isoform X1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Taq DNA Polymerase, Chain T, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
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        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="DNA POLYMERASE I"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR10133:SF62">
        <property type="entry name" value="DNA POLYMERASE THETA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
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    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="165"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="375"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="965"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1190"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1490"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1829"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="968"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="988"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1013"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1028"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1061"/>
            <end position="1077"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1109"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1194"/>
            <end position="1218"/>
        </location>
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        <location>
            <begin position="1234"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1490"/>
            <end position="1500"/>
        </location>
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        <location>
            <begin position="1511"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1829"/>
            <end position="1839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8177561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2645" mass="296449" checksum="61CE89A25C285CC1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0V3</accession>
    <name>A0AAV6U0V3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000795">
        <property type="protein sequence ID" value="KAG8177256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0V3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="8178" checksum="3779700A11FC7AC6" modified="2024-11-27" version="1">MYSSSLRLPITVNELVDLVRLRQRRRISNNCLLLFCARAYHCNGNSLYSSLYDIAALKFSGWILAAEVQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1S8</accession>
    <name>A0AAV6U1S8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000740">
        <property type="protein sequence ID" value="KAG8177883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1S8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="402" mass="44982" checksum="34EFC93E7CD6B416" modified="2024-11-27" version="1">MDKQNSRGCKEHSCNTKAALQYATTLKAHIQNQVFELTAALKKVEHELCMQIDQQCRAKLQGLEYLCEEDKCAPGCQNLKTEFDDNDGFPQKSKLDWDFKVSKRLFQNYGQRRTYDFSKIMARVSEALKDPSVMEQVESGKNVNHDLDSEDCFEFVDSVECLKEELHSEIRNVLKNRGQNLPVDNSEEALERASCSSVDSFDVIPNECCMNDSVCLHAQALPPIARLPNLPEINSPKGGHTTFYLPNLQRKEKKGLFSRILKRSPSRNTSSADMLPSKVEGTEQKMSISVSTTTVDGDDIEVISSSEDITQQEMPMDATDSAVSQGENNPANALQDSFKPYLQKQDLKAWVHPNSKSKANNYEDWVFRVAAPSDPLAELPSSSACSSEAVGAFFRQLQAFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3S2</accession>
    <name>A0AAV6U3S2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_018579</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000661">
        <property type="protein sequence ID" value="KAG8178890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3S2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058899">
        <property type="entry name" value="TGFBR3/Endoglin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF45">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26060">
        <property type="entry name" value="TGFBR3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043955734" description="ZP domain-containing protein" evidence="11">
        <location>
            <begin position="26"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="772"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="12">
        <location>
            <begin position="405"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="805"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="805"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8178890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="846" mass="93928" checksum="8E958235F464806C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4Z0</accession>
    <name>A0AAV6U4Z0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_001834</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2) by facilitating the incorporation of copper into the Cu(A) site of MT-CO2/COX2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000616">
        <property type="protein sequence ID" value="KAG8179592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4Z0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 8 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="111"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="151"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8179592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="288" mass="32537" checksum="36B4D19A66EEF74B" modified="2024-11-27" version="1">MLSVNTAKFSYQLSSRIPSVLRTSNYLFSAKGSHSSPRNYRVNLSLHSRQFHKTPASLAEVLPKKKEFGKGKGPISWKTLAITLGVGGICVGVMQYAKHEKQMERDKQRKRELGKAAIGGKFDLIDHTGQPKTSEDFHGNWLLIYFGFTHCPDVCPEEIEKMIEVVDNLDKVKDLPKILPLFISVDPERDTTEAVAKYIKEFSPKIIGLTGSKEKVNDATRAYRVYYSAGPKDVDNDYIVDHTIITYLVDPDGEFVDYYGQTKTAEQIASAISMQMMKFQKSKKKSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5H2</accession>
    <name>A0AAV6U5H2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000661">
        <property type="protein sequence ID" value="KAG8178899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5H2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="10369" checksum="FC396B8DAC912502" modified="2024-11-27" version="1">MSTLTFTHLGGIKRRENRNRGLSSEVVDLETPSTLHLTSPWQRRSSSAQVQLNSPPPPPSPHGQHKKKQIRLLPNINSEPSLFRRRNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6S6</accession>
    <name>A0AAV6U6S6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H3]-lysine(36) N-trimethyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.359</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_007623</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000634">
        <property type="protein sequence ID" value="KAG8179351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="599"/>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1946" mass="218868" checksum="3450B132AC18B487" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6X6</accession>
    <name>A0AAV6U6X6_9ARAC</name>
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        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_025647</name>
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    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
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        </lineage>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
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            <location evidence="1">Nucleus</location>
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    </comment>
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        <text evidence="2">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="entry name" value="RPABC3"/>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb8"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8179691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12600" checksum="AD25BEB072F21AFC" modified="2024-11-27" version="1">MAGVLFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQAYPMDLGDKFRLVVASTLKESGAPDDGEWNSINDGLPSRADAFEYVCYGKIYRIEGDDATLEASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U884</accession>
    <name>A0AAV6U884_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000565">
        <property type="protein sequence ID" value="KAG8180389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U884"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="111" mass="12478" checksum="B10DF13A15C79B39" modified="2024-11-27" version="1">MENVCCIIDFDGFHVGGQFLVREFGYVGTDKNSNANSIKFDLEPYKKDLQPSDWKTVRFVTKNITGLPLTPVDDENAVSFDCLDSKVTAVYNLFKTPERSVMAFKGKSIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9K4</accession>
    <name>A0AAV6U9K4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposable element P transposase-like RNase H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000556">
        <property type="protein sequence ID" value="KAG8180681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9K4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="1">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="133" mass="14877" checksum="1CA57367331984D2" modified="2024-11-27" version="1">MKFSCKPGILHDVLLLMKRNCESLNNSEKVCILSFDEMHIDSRLCYDSSEDQVLGPFSKVQVVLARGIMSPWKQPVYFDFQKNMTTALLTEIIKAIEISGIIVVAIVADIAGSATLLERTWNLPSSFIIPKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9Q6</accession>
    <name>A0AAV6U9Q6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000538">
        <property type="protein sequence ID" value="KAG8181050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9Q6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="95" mass="9995" checksum="15AC320CA558F09F" modified="2024-11-27" version="1">MPANSSVHLPASPISDSSQLQPNSSVHLPASPISDASQHQRTSNSFTHLFCQPTPACIAQPHPSLMPANSSVHRPASPISDASQLQRTSPGLTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UA38</accession>
    <name>A0AAV6UA38_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase III subunit RPC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_010957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000529">
        <property type="protein sequence ID" value="KAG8181185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UA38"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8181185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44094" checksum="D693010BC86DF407" modified="2024-11-27" version="1">MKLNKNEVTGLFLFLHLRIQLRQMSDHTEDKKPDFSKFPRGAISIKGLPVNRNARLPSIRIPRDLTLGAAKRTFTPNIPVRREKRAAEPNKEAIQSDASTSSKQEIKPTFSKNDRGRGRGRGKDFIQTEGALFEQGIAAAASKDRKQDPSYSKSGLSSKGSSGRKAKADSKMADLSQGLDLYMRDDFINDGSDEDEVKYVGPVMFPIQEKAKKDEAEKNVKQEKVDQNFNDENFAKDLGFDVTKISKFIKKEKSDNVVTVKPTKEALFNLPQNDVTDLFRNDEQCFLIKLPHCFTVPGQDQQSKSQPNSTEKQTNTSIAALPEGRIGKIQILKSGAARLVIGSLNYNLDYVKHLSTKHELVSVNTESGDLSVLAGVKDLLNVSPDIVGSLTALKLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAW3</accession>
    <name>A0AAV6UAW3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Transient receptor ion channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">JTE90_006253</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell projection</location>
            <location evidence="19">Rhabdomere membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000555">
        <property type="protein sequence ID" value="KAG8180695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAW3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000221">
        <property type="entry name" value="Transient receptor potential-gamma protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08344">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="13" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="17" id="KW-1053">Target membrane</keyword>
    <keyword evidence="8" id="KW-0800">Toxin</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="21">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Transient receptor ion channel" evidence="22">
        <location>
            <begin position="181"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG8180695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="308" mass="34832" checksum="D2AB49157A3F0FB1" modified="2024-11-27" version="1">MSDEDDCAEDGHCVPPMQEEIPLLPPHRVAGQLTQEEKKFLLCVERGDVATVRRHLQGRPESGLNVNCVDPLGRSALLMAIDNENLEMVELLIESNVDTKDALLHAISEEYVEAVEVLLEHEEANHTPGEPHSWEAVDRDASTFTPDITPLILAAHRDNYEIIKILLDRGATLPAPHDIRCACQDCVRSCSEDSLNHSRSRINAYRALASPSLMALSSKDPILTAFELSFELRRLSFLEHEYKCEYMELRKQCQEFATALLDHTRSSYELEVLLNFDPFGPAFQQGDRMLLSRLKLAIKHKQKKVGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAX2</accession>
    <name>A0AAV6UAX2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_025926</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000518">
        <property type="protein sequence ID" value="KAG8181379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAX2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8181379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="367" mass="42052" checksum="7508FFF4B7C12BC7" modified="2024-11-27" version="1">MELTSGVRRLIFKFSFISLTCCVLLWFSVFSYGLLYYLYIPSIAHIKPVHLIYDSRCIKDKLCAFPFHNVTLVETGHHDLLSRGQAYAIELALEMPESERNIQQGMFMIHLDMLSEKGEVLKTSRRPALLHYRSPLFKTIFTLFFVPALLAGTVEEKQSLSVPLFEKYVENCHQPTFYAFLEIESTEVEVYSCSLRIHAQFTGLRYMMYYWPMLSAIVGIGTNFFFISIIVIFVWIRQIVNTSQFINVSALTREEQDLVNEIRQSVNRSHSSKDLETEETGISRADEFSDMDSDSSDVEVISPHEDPGNKSLRWYRPTSQTLASSSISEPSTSRQDNLSSEIDNIMNISQPSPSELSPTLRKRIGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBH4</accession>
    <name>A0AAV6UBH4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_027504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000510">
        <property type="protein sequence ID" value="KAG8181519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBH4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043507360" description="MD-2-related lipid-recognition domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="5">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8181519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="156" mass="17402" checksum="D2177B167E33FE2F" modified="2024-11-27" version="1">MTSFITFVILACVAISGATKFEDCGEFTVGGVKSVEISGCPENLDSCILEGNPNKTVAIEFELDTPAEKVTVLKHDSDWSRRFDVAYQANTDACVDSGLTCPLAAGQSYTYTTSFVINYKLNNIDNNRLRFRWILLNQDEYEILCVRVPNKLKKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDL5</accession>
    <name>A0AAV6UDL5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000487">
        <property type="protein sequence ID" value="KAG8181938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDL5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF19">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24768" checksum="691A8172C57659D1" modified="2024-11-27" version="1">MAALGTIEPFDPANADAWDSYKERLEFFLLANDVTEPDKERAVFLTVCGKETYALLKSLIAPDLPSSKTLPQLLTELSNHFKPTTSEISNTVKFFQRSQRPGEGVSAYLAELRRLAVDCNFGANLSRQLRDRFVSGLADEACQRRLLAESTLTLECALGRAKASEAAAEHQLAIRGKFSDANFTKKEGKRTPINRKPMSEKLQKYPNPPVNYTCHGWWRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGC1</accession>
    <name>A0AAV6UGC1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000430">
        <property type="protein sequence ID" value="KAG8183156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGC1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="141" mass="15593" checksum="63EADD2B87EBF574" modified="2024-11-27" version="1">MMVGLGHGHTGSPTSRVPGRGPCVRVPAGPRKLLVQGHHGSRAGNEHGGRVQIRVLIGWHMDGRHVLEHRGSRRSRVLSTKRHQQERGVQVEDSTLWWMYLRFGSLFCIWLSDVFVSTLVGTVKVSGGGFKRHQQEGGCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGS9</accession>
    <name>A0AAV6UGS9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_018653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000448">
        <property type="protein sequence ID" value="KAG8182780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGS9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000001">
        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="114"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8182780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="479" mass="53618" checksum="D7C7AF75FBACD7FC" modified="2024-11-27" version="1">MSHKIVYNGNIIELSYSEIEMCLKVILFLILTTQLKPLSSSDVSSSCSNKDRTFILLDTAMSFLSKAKEIVPRCFYDAHQSKKIGTSSSYLDTTKNLISAAKNVLTSRSRDSKFKVVCYFSSLAFYRTGDAKFNFSAFPPRLCTHAIYVFAKMVNNRIESCRPDLDLPGDIDGYKKFNDLKRKNSKLRTLISVGGCPTGSSSFSPMAADPLARSVFAESVLVFIQQHGFDGLDLNWIYSGEDKGKEEYKRNFVILLQTLKEVLKPKGYLLTSSVSPTKYIIDTTYDIPAISKELDFINLLSFHFRKSWQPMTGLNSPLYANEELSEEAKELTVDFVVDYWLKGGAPKQKLVMGMSLMGRTFTLANSTENGVLAPAIGPGNRGRLKADGLLAFFDICENLTKDGWASVWEPDSQTPYAYKGDQWVSYDDQRSLHAKINYLVKKGLAGGLVWSIDVDDFKGTCYGKKYYLLRSISSKLIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHP1</accession>
    <name>A0AAV6UHP1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRF2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_029517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000430">
        <property type="protein sequence ID" value="KAG8183161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHP1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054078">
        <property type="entry name" value="BRF2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21886">
        <property type="entry name" value="BRF2-like_C_cyclin_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BRF2-like C-terminal" evidence="3">
        <location>
            <begin position="204"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8183161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="401" mass="45947" checksum="EA8D84325DB4AF2B" modified="2024-11-27" version="1">MNRPRIVVLNLPKDKLILNNMGLHCKHCRKDAIDEEDEVCHNCGVVSEGITIDNSYNKFSTETQATFQHYSKKKCTEGLGYGISMLDMLSLKYSVSGKIKSSASELLNNSYATRSFRRKADIGVLAGCCLIHYMKVNKIHVTIGDLCNKLNCTKKSVFKYSKFIKEYLNSQEECRDVKDIEPEEPVEVPMTFDEKVGYTVRSYLENVSVENKDVLVEKTIALTKLANSLWLISGRSTDAVICAASFLCWKSMNQRKQSCNFQKFCKEFSLPYQKGMPRVKEIKDMLLKLGQNIPSFSKNYVNEKNVLFHLDYILQNSESLRNDLLPEEFTAEEVEKKEFSTFRKEFSRFSKTEFFPSAGTSYQDNMDASEVEISDTEISSYIRSDEQVEMMESLQNKALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI06</accession>
    <name>A0AAV6UI06_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_002785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000408">
        <property type="protein sequence ID" value="KAG8183719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UI06"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8183719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9890" checksum="300C0BB02DACB09C" modified="2024-11-27" version="1">MVVKPQGDMSDAPKKVDLGLLEEDDEFEEFPAEDWTAKEEDEQDINVWEDNWDDDNVEDEFSNQLRAELEKCGHKVVNGSGEAMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UK06</accession>
    <name>A0AAV6UK06_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_002331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000372">
        <property type="protein sequence ID" value="KAG8184484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UK06"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="240"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="242"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8184484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="339" mass="38097" checksum="79DA0D08924D99B5" modified="2024-11-27" version="1">MNRNSEPTEKEERKTKKSTISLKLQMTTDQRPSSSFMIEDILGSKKISRSLSLPGTSRSVKDRSIQFSPTAPKKSNTIHQVKNSSGHLDKSYINQLVKDGSMRLTPDHAIISDPTRHPIKPTPMVLSPLCSGFMNFGLYSPVGLSPPAAYYHNQGHNVFSFPPNDLLSPIDNGVFSIRNGQVVRSTVVHASNHLEFANAMHKPSSAIVQQGSFVAIPNLQSDCPSGRPLVWKHVLHRNSPKRKGGQIRFTSDQTGKLEKMFADQKYLSPTERKRLASGLRLTERQVKTWFQNRRAKWRRLKQEHSSRVLSPLSDASNAHLLRQEVIHFANRDDCRSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMW9</accession>
    <name>A0AAV6UMW9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000352">
        <property type="protein sequence ID" value="KAG8184976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMW9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="46" mass="5420" checksum="D6E666A91DC8BDB5" modified="2024-11-27" version="1" fragment="single">MAYMDDNAKKEKTPMYFGFITTSWMLGPLLGYLMSYSFLKYHEDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPH4</accession>
    <name>A0AAV6UPH4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000329">
        <property type="protein sequence ID" value="KAG8185619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPH4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010349">
        <property type="term" value="F:L-galactose dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19163">
        <property type="entry name" value="AKR_galDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000011">
        <property type="entry name" value="Aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044479">
        <property type="entry name" value="LGALDH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="333" mass="37739" checksum="D3B844A8CBB1ED1F" modified="2024-11-27" version="1">MKYTDFGKTGLRVSKLGFGGAELALCYGTANEDKAVELVIKAIKSGINYIDTAPFYGFGKAEIVVGKALKHIPRHVYYLATKVGRYGPDLETLFDFSAERTLKSVQESFDRLGVDYIDILQVHDIEFAKSTDIIINETLPLLQKLKDMKKIKYIGITGYSLNVLKEVLEKSRVEIDVVLSYCRCTLFDDTLKEFLPVFKARNVAIINAAVLGMGLLTNNGPPAWHPAGSEVKEICKQAAKYCQEQNVNISKLAAYYSFSQPDINIHLIGMECDELLEANLLSLHKELTEHEKNVMEHIINIYFKNISVKHWENKEVTQYWKKIENLRNSEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ15</accession>
    <name>A0AAV6UQ15_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000308">
        <property type="protein sequence ID" value="KAG8186259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ15"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="112" mass="12924" checksum="E52E170D748F2F63" modified="2024-11-27" version="1">MHLIPVNGEKISGAQYGENARGNMKQQRRQKKRVLSKRVKVFEAELPIPASKILRHNIPSSEHKHTSFRVDAQSTTKLNHVLVWKSTRALQTERKRVDTDKKNFKKGTRPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQH2</accession>
    <name>A0AAV6UQH2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000304">
        <property type="protein sequence ID" value="KAG8186379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQH2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF70">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 2, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="680" mass="79458" checksum="23664B9B79CDB630" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6US07</accession>
    <name>A0AAV6US07_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004188</name>
        <name evidence="1" type="ORF">JTE90_018638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000336">
        <property type="protein sequence ID" value="KAG8185418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010000303">
        <property type="protein sequence ID" value="KAG8186395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6US07"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41158">
        <property type="entry name" value="AGAP010294-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41158:SF2">
        <property type="entry name" value="AGAP010294-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="168" mass="18208" checksum="7BE7C7807E47A599" modified="2024-11-27" version="1">MDLFLFQQQVSQFLTSKNVIRTLVKLIFGNDEESAATSKQILNIFVSVLDMLKSTLGQRARSATSRSGSKAVLGDAATASASLLKGYIKAFMTNNNSCVQKYLCEASKEAVSDGREVGYLIAQIGGYAASYALENQKSAAFQENYAASRKGRSGEDCKAVYQVCNEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6US80</accession>
    <name>A0AAV6US80_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_022751</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000311">
        <property type="protein sequence ID" value="KAG8186166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6US80"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="58"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8186166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="132" mass="14362" checksum="679538D2D93CC322" modified="2024-11-27" version="1">METASKDTAELQRKSTGTSGVNKLYIQKSTAKGNSKKEANSGNALPLRESDSTSTKLRVVVATHASPYGISAVISHTLADGSKRPIAFASRTLSDTETRYSQIDKEALAIVWGIKRFPPIRVRKTVFVSHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UT95</accession>
    <name>A0AAV6UT95_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome oxidase complex assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000288">
        <property type="protein sequence ID" value="KAG8186815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UT95"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47148">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47148:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14637" checksum="13A458B971302A1B" modified="2024-11-27" version="1">MWIPKTRNRIMVGLSIASGIGTVGVFYIRLRVERAIGNQALCKNSIQDLLQHKQSLAILGEPVTWYNPNLKDSYNRITETNANLAVPVKGPKNKGNLLIDAFRKDGNSDWSLTSLKLKVSEEETVIREKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTU4</accession>
    <name>A0AAV6UTU4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_020031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000277">
        <property type="protein sequence ID" value="KAG8187153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTU4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF76">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="571"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="723"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="770"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="606"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="204"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8187153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="878" mass="96566" checksum="084818E8A52008B1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUD9</accession>
    <name>A0AAV6UUD9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Venom dipeptidyl peptidase 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_009934</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9B family. DPPIV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000251">
        <property type="protein sequence ID" value="KAG8188062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUD9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="15">
        <location>
            <begin position="4"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="14">
        <location>
            <begin position="410"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8188062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="619" mass="71212" checksum="3D9571C356B60189" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUU7</accession>
    <name>A0AAV6UUU7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG8187577.1"/>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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                <person name="De Corte Z."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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                <person name="De Corte Z."/>
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                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000236">
        <property type="protein sequence ID" value="KAG8188542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVQ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="8099" checksum="4512D1D941682DA6" modified="2024-11-27" version="1">MYSVRRTSFAFPFHVIPIRGHMFTPKKMWIEYTTFKSHVIPQMDFEQARFTPEEFDQLVRSCVDRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWD0</accession>
    <name>A0AAV6UWD0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">2-amino-3-carboxymuconate-6-semialdehyde decarboxylase</fullName>
            <ecNumber evidence="4 12">4.1.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Picolinate carboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_005988</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:16557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77634"/>
            <dbReference type="ChEBI" id="CHEBI:77803"/>
            <dbReference type="EC" id="4.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Secondary metabolite metabolism; quinolate metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.45" evidence="4 12"/>
    <dbReference type="EMBL" id="JAFNEN010000235">
        <property type="protein sequence ID" value="KAG8188635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWD0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001760">
        <property type="term" value="F:aminocarboxymuconate-semialdehyde decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901606">
        <property type="term" value="P:alpha-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170033">
        <property type="term" value="P:L-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904985">
        <property type="term" value="P:negative regulation of quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170039">
        <property type="term" value="P:proteinogenic amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000029">
        <property type="entry name" value="2-amino-3-carboxymuconate-6-semialdehyde decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF27">
        <property type="entry name" value="2-AMINO-3-CARBOXYMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="13">
        <location>
            <begin position="6"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8188635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="357" mass="40682" checksum="A55471C026548C70" modified="2024-11-27" version="1">MFFKLDIHTHILPREWPDLKERYGYGGWLRIQHSPNDKNRATLTKDDGRFFRDIESNCWSVTDRLREMDKTGVDVQLLSTVPVMFSYWAKAEDALDLSRYLNNHLASVVREHPRRFLGAATVPLQDPELAAEELKRAVGTLSLQAVMIGSHVNEWNLDNTKLDPFYKTAEDLGCPVLVHPWDMETGGRMSKYWLPWLVGMPAETTIAICSLIFGGVLERFPRLKLCFAHGAGSFPYTLGRIQHGFEVRPDLCAVDNDVPPDSYLSRIYSDSLVHNEESLNFLIKVLGEDNILLGSDYPFPLGESCPGKLIEESNQSSKVIKEKTLGQNALKFLNLQIKDFIWYVPIAMKLYSLDKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWP1</accession>
    <name>A0AAV6UWP1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000248">
        <property type="protein sequence ID" value="KAG8188108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWP1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF130">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="122"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="310" mass="35766" checksum="F1D64684DCCBB00B" modified="2024-11-27" version="1" fragment="single">KCYSPIVLSKVSIKDKETIKWKMNLEETTPLRLDCSSIPEFVCLKAKQELGETEIKIDKCLKEIRKLITNEAKLTSNTSDNFLLQFLRARKYITHEAFDLLKRYYQHRKTYASLYENYSPKQLRDVMDKNIMNFLPTRNSDGCAVWAVQFGKWDPEVTSFDDILRFGLLCNEQALKNPVTQISGVVSVVDLKELSWTHLFHIPSTSLRCYINATQDSLPIRHKAIHVINNPSIFAFLFAALKPLLNPKLKDRIHFHGSNLNSLHQFLPADTLPEEFGGTQGTFQNQKFYSSLLASEDEFIDCNKFGYKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UY84</accession>
    <name>A0AAV6UY84_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cuticle protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_008036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the rigid cuticle of the spider.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UY84"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043843279" description="Cuticle protein 14" evidence="4">
        <location>
            <begin position="17"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8188471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="24972" checksum="EF177F704950115D" modified="2024-11-27" version="1">MKIIAVLFVVISCCYAQLGEVLEIPPMATTRLGEDGTSSITQYNTNDNQGNYDYGYNEGHNQGGTFRRERGDAFGRKVGTYGYTNNEGLIRIVNYVADENGFRAELKSTEPGVAEQEPASVIVFKEDTPTLMTYPGPEASSVPDANGNLPPAPALPPGVAEAYAARFLQNAAASTPQQQVAAAPQQKFAAAPSTQSMQYAASMPYPVFAQQKQTANVRVMSSGQHGTYSYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZI6</accession>
    <name>A0AAV6UZI6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="11">HIBADH</shortName>
            <ecNumber evidence="11">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_012931</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="11"/>
    <dbReference type="EMBL" id="JAFNEN010000205">
        <property type="protein sequence ID" value="KAG8189756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZI6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000119">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="12">
        <location>
            <begin position="14"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="13">
        <location>
            <begin position="176"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8189756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="313" mass="33370" checksum="76855C80CA1B14BA" modified="2024-11-27" version="1">MPIRSIERSASQTSIGFIGLGNMGTHMARNLLQKGHSLVVYDVYPEAMTKLGDSGASIAQNPAEMAERCDRVITMLPSSPHVQEVYAGEQGIFQQVKPGTLLIDSSTIDPSVSRDLAIMAEKRGALFLDAPVSGGTNAAKEGKLTFMVGGKEAEFQAIKDILLCMGQNVVHCGKIGTGQAAKICNNMALAISMIGTSEAMNLGIRLGLEPKMMSKILNMSSGRSWSSEVYCPVPGVSDSVPSSNEYQGGFGTALMAKDLGLAQLAATKTSSPTPLGSLAHQIYRMMVNSGFSQRDFSSVFLYLQEGQTFNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZJ0</accession>
    <name>A0AAV6UZJ0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000208">
        <property type="protein sequence ID" value="KAG8189652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZJ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="218" mass="25225" checksum="CA2BBEC37208F100" modified="2024-11-27" version="1">MKELPRYHYTLVTTPHRAYRTYLENLRAAAPPAKYRFITQGSVEENAPQRNHNGLWMWGRRVWNLLVSETVVNNRCLKFSRIQHLYHCTCSKETSHYWFLPSTFSSTIENMKEFRTSPKDGDEVTLIYAKHERLPVKDFAAEVRASMDVGQFLNQAGLFRTSSQDTSVEGIIDKMLNKVLDSRESLITISEAKEAIFTEDSVHLLSRTIQETYVTEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0D0</accession>
    <name>A0AAV6V0D0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="34">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="34">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="36" type="ORF">JTE90_012507</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="36">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(2E)-geranial + NADPH + O2 + H(+) = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54860"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:54861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:11261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>heptan-2-one + NADPH + O2 + H(+) = pentyl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54836"/>
            <dbReference type="ChEBI" id="CHEBI:5672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:87362"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:54837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>heptan-4-one + NADPH + O2 + H(+) = propyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89484"/>
            <dbReference type="ChEBI" id="CHEBI:89719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:54853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>hexan-3-one + NADPH + O2 + H(+) = ethyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54844"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88764"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:54845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hexan-3-one + NADPH + O2 + H(+) = propyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54848"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89828"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:74111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:74112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:69819"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:69820"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>octan-3-one + NADPH + O2 + H(+) = ethyl hexanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:86055"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:54857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>octan-3-one + NADPH + O2 + H(+) = pentyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:87373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:54841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>sulcatone + NADPH + O2 + H(+) = 4-methylpent-3-en-1-yl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16310"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:54865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:31979"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15724"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.14.13.148"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:31980"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 33 34">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 33 34">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="36">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="34"/>
    <dbReference type="EMBL" id="JAFNEN010000215">
        <property type="protein sequence ID" value="KAG8189433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0D0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034899">
        <property type="term" value="F:trimethylamine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000159">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002257">
        <property type="entry name" value="Flavin_mOase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01125">
        <property type="entry name" value="FMOXYGENASE5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 33" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 33 34" id="KW-0274">FAD</keyword>
    <keyword evidence="7 33 34" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17 33 35" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="15 33 34" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12 33" id="KW-0521">NADP</keyword>
    <keyword evidence="14 33 34" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 35" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 35" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EMBL" id="KAG8189433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="546" mass="62036" checksum="F806FDD22FF2FF9F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2E0</accession>
    <name>A0AAV6V2E0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000170">
        <property type="protein sequence ID" value="KAG8190947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2E0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11484" checksum="55A9DA4FD1330F1A" modified="2024-11-27" version="1">MSNRRSSLSKGQTKKKNLLKFYQLDKTNSSQFQLRKKTERRAFWPRNKALQPVCQEAKPETAPKVLSADKTPSPQFPATKEAERRAYCPQKKALQKTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2U3</accession>
    <name>A0AAV6V2U3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neurochondrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the neurochondrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000199">
        <property type="protein sequence ID" value="KAG8189946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2U3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048168">
        <property type="term" value="P:regulation of neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109:SF7">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="670" mass="76259" checksum="5567DC603032D654" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V325</accession>
    <name>A0AAV6V325_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Glutathione S-transferase 3, mitochondrial</fullName>
            <ecNumber evidence="16">4.4.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Glutathione peroxidase MGST3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">LTC4 synthase MGST3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">JTE90_011927</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:48620"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57450"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:90632"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:48621"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione</text>
            <dbReference type="Rhea" id="RHEA:75963"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:85236"/>
            <dbReference type="ChEBI" id="CHEBI:194498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:75964"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>leukotriene C4 = leukotriene A4 + glutathione</text>
            <dbReference type="Rhea" id="RHEA:17617"/>
            <dbReference type="ChEBI" id="CHEBI:57463"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="EC" id="4.4.1.20"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:17619"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Lipid metabolism; arachidonate metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Lipid metabolism; leukotriene C4 biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPEG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.20" evidence="16"/>
    <dbReference type="EMBL" id="JAFNEN010000191">
        <property type="protein sequence ID" value="KAG8190205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V325"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004464">
        <property type="term" value="F:leukotriene-C4 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006691">
        <property type="term" value="P:leukotriene metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000004">
        <property type="entry name" value="Microsomal glutathione S-transferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAG8190205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="168" mass="18787" checksum="09F7124836B304CC" modified="2024-11-27" version="1">MGVASSCDKVYFDLGLEGYQAFQNRNCIKMVVIDIPKEYGYVVLVGTSSVFVAMWHGIKVGMARKKYGIKYPAMYSDTNVVFNCIQRAHGNFLENYPQFLFLLLVGGLSHPRLSATGGLVYLVGRIAYTLGYSTGDPQKRMRGMFMHLGVLTLVYTTAHFATNLLGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3Q5</accession>
    <name>A0AAV6V3Q5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_017863</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000179">
        <property type="protein sequence ID" value="KAG8190598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3Q5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="39"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="151"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8190598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="520" mass="58047" checksum="681A70B03D6B0B8A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4N7</accession>
    <name>A0AAV6V4N7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubinuclein middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_010861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000169">
        <property type="protein sequence ID" value="KAG8191003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4N7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026947">
        <property type="entry name" value="UBN_middle_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14075">
        <property type="entry name" value="UBN_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubinuclein middle" evidence="2">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8191003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="815" mass="88845" checksum="204A513655529EE7" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4T1</accession>
    <name>A0AAV6V4T1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ecdysone-induced protein 78C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_006053</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4T1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001728">
        <property type="entry name" value="ThyrH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF10">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 78C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00546">
        <property type="entry name" value="THYROIDHORMR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="96"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8191301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="40713" checksum="5E3F01D9670C11DF" modified="2024-11-27" version="1">MAVTAIKQGFFRRSIQKQIDYKCLRDKQCLVIRLNRNRCQYCRFRKCLDVGMSKDSVRYGRVPKRSREKSEADPPARVINQFTADNEKTEPRQQASMYDIITTISDAYLYHCAYTEAKTRGLVRKPAFFNMSEQQQSNALDGSNADVQKIVLWQQFAHLLCPSVQQVVEFAKKIPGFQELPQDDKLLCIKLGFFEVWLVQASRLISPQDSTITFTDGTTISRQQMEIMFDRDFVNQVFNFVHCFNDLQLSDAEIGLYSAVVLVTAEREGIYDVKSLSHLQDQMISALRYKLGAAQNPNSAVELAAPQHPRAFRGGVRHSQQAGGRGWREVDDFYLEEILNHPTCWHERFQCSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8Q1</accession>
    <name>A0AAV6V8Q1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000142">
        <property type="protein sequence ID" value="KAG8192253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8Q1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="10720" checksum="082AA84DA0CA3CED" modified="2024-11-27" version="1">MYRLTNQNSTSTPSRDTSDKWGKREGALCEFSFLHLCGEYEHHGLNCRFQLGRKWETGGTYVMGMLREYQDGLTRPVKRNEKWFVRWLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VA38</accession>
    <name>A0AAV6VA38_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_003784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000125">
        <property type="protein sequence ID" value="KAG8193297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VA38"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000135">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="600"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8193297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="69659" checksum="4A5406D1D740F417" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VB15</accession>
    <name>A0AAV6VB15_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000134">
        <property type="protein sequence ID" value="KAG8192871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VB15"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="154" mass="17323" checksum="4AC4A1D1F0988B0C" modified="2024-11-27" version="1">MYFSVGWPAVSSGITTQKAVHCTGVFEDESPFLLTIQSLTSFVHQSFTPRIFLEGKRIAVIETSEDSKLGQRGLKRSRNCPPDKALGLYFLEEKKRHLEANKQMTKTKNEAGNWSPIYAPCKGLPRGVFSRAPAARDSCPISFSNDKSWCNHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBD5</accession>
    <name>A0AAV6VBD5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Complex I-MNLL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000125">
        <property type="protein sequence ID" value="KAG8193284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBD5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012575">
        <property type="entry name" value="NDUB1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08040">
        <property type="entry name" value="NADH_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="9286" checksum="38F0B1FB3D15919F" modified="2024-11-27" version="1">MNAKALNLKKVNMFKINPWMKNYWLAILPFGGFMFGRWFDKQETIRMSEFADKSYMYGRKERVEGDYSPWDKYLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBG5</accession>
    <name>A0AAV6VBG5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000125">
        <property type="protein sequence ID" value="KAG8193314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBG5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="199" mass="23148" checksum="29D7D79A565EC489" modified="2024-11-27" version="1">MSQIRQLKTKEMQTFKNLFDHLWNNASNYKIIKRIDFVFDSYVEHSLKEGERERRRNVDPIELIQIEQDTHIPIQMDRFWSSCKNKEMLQSAAATSFIEKAKMANFTTVLSGTITGDSRDAKIVMNKEVCSDVRTFVEEADGRIVMHLFHAVQSGITCLIVLSNDTDVVVLLLRYIFQLFSNGLQELWIKINSYQSMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBZ7</accession>
    <name>A0AAV6VBZ7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000128">
        <property type="protein sequence ID" value="KAG8193166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBZ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="214" mass="24229" checksum="132FBBF646B8B3E5" modified="2024-11-27" version="1">MTDCPKPGSHWYHLKYFYHSTNEKTEPPASSYPVNFTTVAPTNSPANFLYNKYVVIGVLTFFVTIFLLTIIIHIVRSRICAREPLHHYSIASEEGSSLMGSDDENLDNLYTSCQLYVAEDDELPTGDDFEYDCSSLDGGLSVTERKALKPYVDQRRVIGALAFFVTIFLLTIIVHIVRSRICNREPIHHYSIVSEEGSSLMSSVDENLDNLYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCT6</accession>
    <name>A0AAV6VCT6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-latrotoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_005006</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Homotetramer in membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cationic peptide 01 (latrotoxin) family. 03 (alpha-latrotoxin) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000115">
        <property type="protein sequence ID" value="KAG8193708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCT6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="12" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8193708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="622" mass="71787" checksum="962B8A3BD9B32836" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDX1</accession>
    <name>A0AAV6VDX1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000106">
        <property type="protein sequence ID" value="KAG8194258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDX1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="8651" checksum="6511D8A6C13CC9A9" modified="2024-11-27" version="1">MRSSDIRETTCAHSVSLADRAVFQADMVLGPRAKAEERLCGHYYGFVTVPSIAFALRRPVVHEGTGYCGAFHEGSLGHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF19</accession>
    <name>A0AAV6VF19_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VF19"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="185" mass="21307" checksum="D26CE5806C9AA6DE" modified="2024-11-27" version="1">MALTRKLAFKIDFICSASFIRYQQEWVPIQMVFAAINDSKNVKVIAPKPDSMISFTMENILINENLPDQPWYAISQEDGTQHTVIVTEMKDFISAELYQAHLTHEDLWPAHIGTLDMNTYHYLLPLLPIGHVHFLGMKILPEETLFGPQKKIGLLARKAANILHIEREISKWNKGPEEDSEFLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF36</accession>
    <name>A0AAV6VF36_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000088">
        <property type="protein sequence ID" value="KAG8195420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
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                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">W744_W776</strain>
        </source>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
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            <dbReference type="Proteomes" id="UP000827092"/>
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</entry>
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            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
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                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
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            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAV6VHQ6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
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            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000086">
        <property type="protein sequence ID" value="KAG8195497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHQ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="137" mass="17291" checksum="C44B7CEDACC8D25F" modified="2024-11-27" version="1">MNIRRWLGNRKGLRKHRRRVRRRLGNRRGVRKHSRRFTRWLGNRRGLRKHRRRVRRRLGNRRGLGKYRSRVTWGLGNRRDLRKHRSRVKRRLENKRGLNKYRKRVTRWLGNKRGLRKHRRREAQEKIYKAAWEQKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VI28</accession>
    <name>A0AAV6VI28_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_010621</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000079">
        <property type="protein sequence ID" value="KAG8195743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VI28"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15045">
        <property type="entry name" value="7tmC_mGluRs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06362">
        <property type="entry name" value="PBP1_mGluR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000145">
        <property type="entry name" value="Glutamate receptor, metabotropic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000001">
        <property type="entry name" value="metabotropic glutamate receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000681">
        <property type="entry name" value="Metabotropic glutamate receptor-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000162">
        <property type="entry name" value="GPCR_3_mtglu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00593">
        <property type="entry name" value="MTABOTROPICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043383798" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="14">
        <location>
            <begin position="26"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="676"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="799"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="866"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="15">
        <location>
            <begin position="641"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="904"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="909"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="928"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8195743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="989" mass="110972" checksum="69B8E35822AE6B99" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VI45</accession>
    <name>A0AAV6VI45_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000079">
        <property type="protein sequence ID" value="KAG8195758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VI45"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="111" mass="12070" checksum="F16A2B32AD466C41" modified="2024-11-27" version="1">MPIPPDVLCPGFPFVMGPVNGIGFKPPPLRLWAPQLGGGEAPVGPKKKNQAQGTAVAAKEQKHRISPSSQIERWRQMRGIQARSDAVIGRKVEKASQRLGEMFSRVVVVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIT0</accession>
    <name>A0AAV6VIT0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000065">
        <property type="protein sequence ID" value="KAG8196707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIT0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8580" checksum="0D98FED3522E7207" modified="2024-11-27" version="1">MIQPEDAEQCGPHPNGMHGMPHHPESLFILLLDESHDNGQTIAKELEEKTENIEINSSAKEPIDLYHPLSKAKRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLV5</accession>
    <name>A0AAV6VLV5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_001638</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLV5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19683">
        <property type="entry name" value="bHLH_SOHLH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039583">
        <property type="entry name" value="TCFL5/SOLH1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15402:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15402">
        <property type="entry name" value="TRANSCRIPTION FACTOR-LIKE 5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="10">
        <location>
            <begin position="355"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8197715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="426" mass="48418" checksum="5647B6911F80924C" modified="2024-11-27" version="1">MEDIAYQFGSENINLTDVNINDGDCTSFVTDHEDSARKRLDSDEDFQTIDHEQFGDITSFPGLNPRTTEIEEDLKIVYDSSTTVCSSDLQYNKECIKDFQDCRIVNHHDVKESSTEEEPRPKPFIRRGAQLIRLQVAPDPSKQQPINVEDDDDLKKDNTSTILFQEAKLENVKFELAKNAEEPDFKLLTPKVPAASQKQILELPNSENSSNFTKFQDIRHSENVTIQGIPSTSQASIVFIDDTGSDFILPRTKECSPKTPTVSKTEMLEENSSLPRSLTDVTTDSTRVNSNSSFPSINLSGTVSSDYQSFSSTSPHGSDFFASKYIQRFITADNKVVYGCKDTNGEFNYVSQDFIDKQTHNEKERFRRSRVSGACGALRKLVPGLTERTDKATVFERSALYLTFLRDKFQSQFDQSYREKYFTERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNV1</accession>
    <name>A0AAV6VNV1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
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            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
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            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000043">
        <property type="protein sequence ID" value="KAG8198160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNV1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="9738" checksum="ADF2E020B471C45F" modified="2024-11-27" version="1">MCPKTFFLVPITTHGNSVVFHFDPPTPYTLTVLAANLAALVHFYSQPTDHPLSTRNSTHASSSSKYCSSIAEWALIRSGPVVGATDSCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
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                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="PANTHER" id="PTHR34347:SF1">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4503" evidence="2">
        <location>
            <begin position="894"/>
            <end position="1079"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
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            <dbReference type="Pfam" id="PF14951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8198189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1090" mass="123746" checksum="4AFAE01BD12A1176" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS23</accession>
    <name>A0AAV6VS23_9ARAC</name>
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        </submittedName>
    </protein>
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    </gene>
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    <reference evidence="2 3" key="1">
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="9013" checksum="18D9803079E74B9A" modified="2024-11-27" version="1">MEHASEMELEESEMTTKQRDDAMFVYKSLAEICYKNMDRASADEMLMKYKREMPEFRPHPYTSGLLGPRTTSSLLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT02</accession>
    <name>A0AAV6VT02_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Araneomorphae</taxon>
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            <taxon>Araneoidea</taxon>
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            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000035">
        <property type="protein sequence ID" value="KAG8198804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="97"/>
        </location>
    </feature>
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        </location>
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            <begin position="71"/>
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            <end position="123"/>
        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="956"/>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8198804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1336" mass="147034" checksum="A787BCEADA327A07" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTS0</accession>
    <name>A0AAV6VTS0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <dbReference type="NCBI Taxonomy" id="931172"/>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000030">
        <property type="protein sequence ID" value="KAG8199156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTS0"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="245" mass="29739" checksum="FAE8547739C7AED3" modified="2024-11-27" version="1">MEKTEMELQQELLKLTAQYKETREKNKILQEENEKLENLYVFFENQLKINEKNCERCESMRYEIAALCEETPRIIKTIKDLDSKEKKLREEILDTFPKRFKDITKQKQKVHKECLYHMAFVEENKAQEVVLKEYLTEEIKEKELMKAKAERKMARRVKRTYGIWNRKKDLWYNSDTDSDEETVTRKALQKKGNKKLFWDDDDDDEDKFDSVKYDFSSSAKKAEVKLRYNHQIVPKDKKKRTEHMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000019">
        <property type="protein sequence ID" value="KAG8200125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUA5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="112" mass="12176" checksum="9B93DB07F6EF3960" modified="2024-11-27" version="1">MHPLVICTQKKRHLSQSQSHSRYPRSKCQTTDNTVPMKLLPAHRGSASEESEYALLLVLKKCAKLASESEVCLPPPMGLHDVVEEHRNSDWCVSDAGIDLSAAAAAALPSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUK4</accession>
    <name>A0AAV6VUK4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUK4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="106" mass="11966" checksum="7C0980BBE565A559" modified="2024-11-27" version="1">MPCALLTYLKHIYNYPLPPTLISSIRPADTPTHKYTNSAAPNAHRHFLPPLLQLDNPTPQPPGRFLQFLRSSEKRLIEGINLVRCRTGDQRRTDGHTLRLAFVPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVU5</accession>
    <name>A0AAV6VVU5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000008">
        <property type="protein sequence ID" value="KAG8201087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVU5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8574" checksum="6A72B5AB93AE054B" modified="2024-11-27" version="1">MIVVSKENRSSYLLSIASGFEGSPESGALESEGPPTRCRAESFLRWNRELGYGLTRIGTLLLPSSGEWMVPRAPLPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWU9</accession>
    <name>A0AAV6VWU9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000008">
        <property type="protein sequence ID" value="KAG8201135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWU9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="14242" checksum="A46FC9217CDCAE41" modified="2024-11-27" version="1">MRHFLANDRKLPTQVEGKYAFPSESSVSNVQNILRATIFANRSDNSGGWKKGMLENPLRLRSSCEISTDRGLWRGSRKSPIFADRAKLEIFFFAGAFFPLSVFPFNAPFYLWSNPGSLTSNIFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWY6</accession>
    <name>A0AAV6VWY6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000006">
        <property type="protein sequence ID" value="KAG8201314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWY6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010738">
        <property type="term" value="P:regulation of protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052641">
        <property type="entry name" value="AKAP7_isoform_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934:SF2">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 7-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934">
        <property type="entry name" value="RNA 2',3'-CYCLIC PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="372" mass="42846" checksum="B0481BF69764B507" modified="2024-11-27" version="1">MKTNYLNKFLSTFLTSSSNSIYFEEVYLTGSAYLCYVICESLRLISQRHFKLQKGSPSKESTLTETVETCSSVKLVPLKSEDVNYSERLIPVNESFNKNVKTINVKQPKGSLPVDQYSYHSSKRLSKEEHLQSKRPNYFVAVQITNTKIHENIKEIQDYILSQDSTFDECMIPIPTLHITLMVININNLKTYERAKKALANIHKEHNEIMCKNPLVLEFSGIGHFNNKVVFGKIKENECLTRFCQLAISVEKHFAEVGIPTTDQREFNPHLTIAKMKFPKKNKKRPNKFSELLYEKCINSYLGVETIRSIQLLRMDGPKDSSGYYTGYELMFMPSSPPTFARVHEIAEKKRKIREEIADTVKACTSSSKENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXU0</accession>
    <name>A0AAV6VXU0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000004">
        <property type="protein sequence ID" value="KAG8201539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXU0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="10567" checksum="023C7C973DFEA052" modified="2024-11-27" version="1">MQKRDAKNTKGNPLSLITFKENTFHRLRIMTQESERVTSVPWDLANMFLRTCSKDLLWRFYHLLTVARFDKTEDFSQLLENKCAVLETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VY49</accession>
    <name>A0AAV6VY49_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_022271</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VY49"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033549">
        <property type="term" value="F:MAP kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14515">
        <property type="entry name" value="DUSP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020405">
        <property type="entry name" value="Atypical_DUSP_subfamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682">
        <property type="entry name" value="AGAP008228-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01909">
        <property type="entry name" value="ADSPHPHTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="110"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="184"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="7">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR620405-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8200649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="270" mass="30291" checksum="F03B80360855220C" modified="2024-11-27" version="1">MNSYTHLDSASRFYSKAFNDYLVSRALDAPVARRRTPLPRFSTLKKEKAPRPASTTFLDTYRRRDPNYQISKIPNYGDSYLSRRAVPLCTPDDLLDIIRDPSGYYVLPTDPCNEVFPNIYLSDAPTALCTALLKRMGITHVLNAAQGKEKHCGLVNTWPGFYSQSGIKFLGVPAFDNIVFRIHPYFEEAAQFIDDALKAGGKVLVHCQAGISRSATLVCSFLMLKRGFTAQEAVKAVRKNRAIIPNDGFLQQLCDLNDKLSRNRTVELSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYH1</accession>
    <name>A0AAV6VYH1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000013">
        <property type="protein sequence ID" value="KAG8200761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYH1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF4">
        <property type="entry name" value="AXUNDEAD, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="25"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="442" mass="49835" checksum="91CD3076C2F918D3" modified="2024-11-27" version="1">MSLSSSVSVVGVGAGHHLFFSERDSDVSVRVEWDGGAVRFPSHALVLGTMSDVFRTMLDTDMLERREKMITITDSSPRTVKHFLRYLYTGLVEFTTWEDASSILQISHKYSVQPLTLLAESFLSNALSLSNVCALLDLARTYSLSTLRRQALVFLLDTGFVASASEGFFELKPTSLDLVLSNERFNAEDEGSVLSVLREWAVCECSRRCVPLSETNVLGAMEPFLKYIRWTQIPESQRTFVPRQLVDKHRNPQLDPRRPFHVPPAIQYHVSLVKFVVELGAYHSSYENRGSHLTCLKFGVSNHAFLVGFRIIGLFRISSCLFPGPSCLALSKEDNKVFLQFNLNSLTWTKGSTVGRDAWREMIAYLPFPVRIDPFGTYNLSIRYSGRGKELLTAKWPRTRLDSEVVNTDLGVINFRAYGPCFGVTQLFLLPAPPYRSVCNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYJ8</accession>
    <name>A0AAV6VYJ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_006366</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000013">
        <property type="protein sequence ID" value="KAG8200784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYJ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="37"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8200784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="490" mass="52640" checksum="E340F640DACB2765" modified="2024-11-27" version="1">MDRNADKVAKNGSTNGMENGSVGKKAETKSSTKEWVKLATLAFGNFCSGACLSLQAPFFPKEAELKGSSPTTYGFILGTYEITVFLTAPIFGMLVRYISPTYLLNIGVMTVGTACVLFGTLDLVADSTTFIALAFALRALEGVGSALTRVSANTVVASQYPERLGKVYALLQMFSGIGVIAGPTLGGALYDIGGYGLPFYAIGSGFLVDAIIIHFLLPKVETTKIQEKVSFIKLLLHPTSFIFLLSAFTGQAYLGFSAATLEPHLRQFDISGFVVGLVFSITGILYAISAVAYGWILDKKIVSAEFLTVGGCFVIVVSIVLMGPAPFIPLGPDLWYIFMAQALFGIGLGAKFVSSFTGMLTSASNREFPDGLSTYGIVTSAITSATSLGSFVGPSLGGYLLEQFQYRKATMFILFQEIILIILLTISLIKSMLCGNADKLSLRHELEIPPKNHQIISEKYVTNCNIKKMKDTTKTVGRNGCNEGYHEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W1D5</accession>
    <name>A0AAV6W1D5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_011218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000004">
        <property type="protein sequence ID" value="KAG8201543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W1D5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="143"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="319"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8201543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="55396" checksum="18A05947DFBFDA74" modified="2024-11-27" version="1">MLPHKCGDGLTSAYFTTQIFDGTDFFLKLFPRGVNPSENSVSCVLYRKNTDAVPIQIGFSLTLLSNDGLGNKGFSLESVKLFTGKGYSNFVELGYLYGNKDHYLPRDVLTIKCQVWSPENKVTASQLEIENAFSSITRIQVNKNCVIWPIKNVEKLRTSKSKTSYHIKEALENIPSLELVFSMGDDSNEEYAQIDITQCSIKSEISSSISIFVKCKMTVMSVSEEYQHSQEDTFLFELNAPQTWHFPKFIAINNLKADKYIHMNDTLFIMCEFWFSSKGYPTFHEQRAALSHVLQMPHVPQASPLNNNIQKLYTSATLCDVELRVGNFTFPAHKVVLCAQSPVFLAMFSNDMKENSTNVIEIVDFRSPIIQMMVEFLHSDNIKDAERLQIEDICDLYSVADFYQILHLKQFCTRLLLSDMVQINGPYSVLRLADRYEDHFLMSCALHFIQTWGIEYFLSGDWKMFLDENPSLCGKVMIEVMKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCP2</accession>
    <name>A0AAV6TCP2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007417">
        <property type="protein sequence ID" value="KAG8155665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCP2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="170" mass="19065" checksum="2FC9EFC578EAEEA5" modified="2024-11-27" version="1">MFLLFQKKPFPPSRAPTIKGPPVLILPQKYCHKIKKHVHSRQTFSTPPRPGCILRGARKKTRVEKDTSDKLATRTHKLTPHSPPMYDQNMPHIPTEKIFRDGGARQGGRTTRRKAETGEAARLADTVPPLNPGSTDTVPHFKAEQKLLPTKKPFFPDVPPPAFSSALFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCR3</accession>
    <name>A0AAV6TCR3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007274">
        <property type="protein sequence ID" value="KAG8155683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCR3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019173">
        <property type="entry name" value="NADH_UbQ_OxRdtase_B5_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09781">
        <property type="entry name" value="NDUF_B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="58" mass="6333" checksum="120E520980E86138" modified="2024-11-27" version="1" fragment="single">MEISPTATKNPILRGDLTSTSPKGHPPGGESPYSNIFIGQGTLEDIPEGYTPRHWGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TD44</accession>
    <name>A0AAV6TD44_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006544">
        <property type="protein sequence ID" value="KAG8155843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TD44"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="14006" checksum="2554A16E7DE8125B" modified="2024-11-27" version="1">MPRGSHAFIATVAFDPSSRLLLALRSMNRQALDCSPIIGNVSGFRTVARQVSFNLLDDSSFAIVILLSTRGKRRFGHLGYWCLVERPVVRKGYNSVGMMTERSKSESRLGRLQRYRRTSASVGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TD99</accession>
    <name>A0AAV6TD99_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006484">
        <property type="protein sequence ID" value="KAG8155903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TD99"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="112" mass="12208" checksum="A0AB8A0CCEF6DEEC" modified="2024-11-27" version="1">MIGRADIEGSKRNVAMNAWLPNEPFIPVRDKHEHVFAFRQTSRFGTDFSDPLGPTDPCSTAVHMEPFSTLQSSRFSLEYLLLPPRSAPVAAPGGLTPAPSTHATATPYSLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TE13</accession>
    <name>A0AAV6TE13_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_002834</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plus-end directed microtubule motor that may be used for anterograde axonal transport and could conceivably move cargos in fly neurons different than those moved by kinesin heavy chain or other plus-end directed motors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006452">
        <property type="protein sequence ID" value="KAG8155926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TE13"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01371">
        <property type="entry name" value="KISc_KIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000029">
        <property type="entry name" value="Kinesin-like protein KIF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF21">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="10"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="369"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="651"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8155926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="675" mass="76392" checksum="A65A3FFD6BF74A9F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TG48</accession>
    <name>A0AAV6TG48_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004909">
        <property type="protein sequence ID" value="KAG8170769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TG48"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="123" mass="13454" checksum="7B72218A53C6FC5C" modified="2024-11-27" version="1">MGTDRDEITYLPPDFPKGPKRGAPDTARERAFTRKRPPLRTAIPPGETKSYKEKIIFPGSSVDVSGVRCVPHLVPKGPISVSGLGILKTPFPFRSANETKPSMCLRLADVSLLERISPDPLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGZ9</accession>
    <name>A0AAV6TGZ9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Synaptonemal complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_003595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004971">
        <property type="protein sequence ID" value="KAG8170731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGZ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8170731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34383" checksum="82179C4849C4FA2C" modified="2024-11-27" version="1" fragment="single">ISEHETTIKELEECIEKYQSDVECKENSIESYKKEVDALKAKLEEKNTLLQEQSDVLGQLEEVCAKNEELEKNMAEMNKGISKKEVEIASCIEELEILKIELEKAKLLQEQSDMLCLSLQKCELAASNKIKFLNSCVVKYQDEIADMKRQMKEKTDSIDELEKALCESQKQIKDMQSKISKQVEEKRQDAARIEQVLHEKKVAENYKLKVDLKKAQERESLNAFEEAETSANSTKDEAKQSSNTIPKGRKKRSLSDITKEANDNVGLKENAKSTNKVQEKKPSKTTKVEPVKTEESETVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJI7</accession>
    <name>A0AAV6TJI7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003466">
        <property type="protein sequence ID" value="KAG8171863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJI7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="109" mass="12399" checksum="852CCBAED6B260ED" modified="2024-11-27" version="1">MQFSSFVIVGSQLFIVGHRYTTSSNPKKKLPSKIRFGFRRLNCNREVEAFCLNGGKGAIVELKQFRKSYYVGFAKIGAENEIRNRFNFEVSLLPNVQKALEAVQEHLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJU4</accession>
    <name>A0AAV6TJU4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003429">
        <property type="protein sequence ID" value="KAG8171884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJU4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="62" mass="7116" checksum="B9DDBA109FF8C3C7" modified="2024-11-27" version="1" fragment="single">MYDFVAVAEFLFLQGVLVPFRVIFTSTRNPDKTILLEADADTLQMTYADVRKNLQMSPLLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TK83</accession>
    <name>A0AAV6TK83_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003096">
        <property type="protein sequence ID" value="KAG8172116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TK83"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="9631" checksum="CABBB2A903A370E7" modified="2024-11-27" version="1">MMNSRLTRNFSFMRIIGNRQSPARKRFTGYPFLFEREAHDDSFNVARVLPRTSKGIYRPAIALGLVRLKPPPVPLRETKETPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TL80</accession>
    <name>A0AAV6TL80_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM98 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002588">
        <property type="protein sequence ID" value="KAG8172562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TL80"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018797">
        <property type="entry name" value="FAM98"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353">
        <property type="entry name" value="FAM98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353:SF1">
        <property type="entry name" value="PROTEIN FAM98B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10239">
        <property type="entry name" value="DUF2465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="141" mass="15742" checksum="BD14E11FFD563272" modified="2024-11-27" version="1" fragment="single">MEDNKQRLVDIFEDLTNLGYVGVIENPETLSVAFNNDVPNYLFSAVVTWLSSNLSTILKLENGITVEAEDSLKTGSLKDPLPNPLAFLVEMSSLLKELGCPIKRLTSGNLENRFKDPINRLLAVEYMIQELRASKVVQSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLI6</accession>
    <name>A0AAV6TLI6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_011394</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002424">
        <property type="protein sequence ID" value="KAG8172744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLI6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004995">
        <property type="term" value="F:tachykinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001681">
        <property type="entry name" value="Neurokn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="122"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8172744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="170" mass="19533" checksum="D8E6DF70047DDB11" modified="2024-11-27" version="1">MGNSQKKEVDLLEMYMDSQKQTSSYNSSVCDEIHRRVYGNLTTEESVVTVIQDKFSNYSLTTDKSVDIVIQDKFSSYSDLFAKCFNSTIPSNIFNQPYILPWYQQLLWTLLFAVMILVAIVGNTIVMWIIVAHRRMRTVTNLFLLNLAIADFLLASGNATFNFIFMLNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLM3</accession>
    <name>A0AAV6TLM3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002574">
        <property type="protein sequence ID" value="KAG8172573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLM3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12225" checksum="C6DA6631B2CCCE58" modified="2024-11-27" version="1">MANNLLQIPEKLAHGITDFISTKISKTSFWIGFKMEDRSMSKAKEDRDWTFDYDDETVVEKDFELWAESPREAALNCAIINGSNSFDVSAVDCGGARLPVVCTRAKGSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNI9</accession>
    <name>A0AAV6TNI9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001677">
        <property type="protein sequence ID" value="KAG8173520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNI9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="169" mass="19697" checksum="A41251D7FBB8AD97" modified="2024-11-27" version="1">MKNERQFYLKNNEMEKYAKNDEDEYYAQKPDNSEYYAKKPDLSEYFAHKSNNEEFYTDGLQGQTYPKTNLKSEFYMTKNDRNICAENMNREFYYAKDATGNEFYPKQISSEQDMLNVDKASENAPEDENAPEDAPEDENAPEDAPEDENAPEDAPEDENAPEDAPEDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNL0</accession>
    <name>A0AAV6TNL0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001861">
        <property type="protein sequence ID" value="KAG8173348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNL0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13481">
        <property type="entry name" value="AAA_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13155">
        <property type="entry name" value="Toprim_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="335" mass="37678" checksum="09FD4EE1832DA7D2" modified="2024-11-27" version="1">MMFDSIDQTDFSPLNGKQIIIWPDNNEAGKQYAEKIANKLSNLKCSILNIPEGKKSGWSALDAIAEEIDINRLLISANPVVKENISAFSVKQYLNDKSPIPKDIISPRILIPGGLLVFGGTPKVGKTDFLISWLANMSAGVPFFDMVPVKPLKIFYLQTDVGYHYMRERLQQLKIDSKLLDLVANNFAITSDTNLLLDESKVYNTVKQFFNPAEVDVIVIDSLRNVFNYRNENDNNVMYSFLQEKVEKLRSTINPSAGVILTHNVNKKLPKENPFQSLSGASSLRNVYTSGMLMLKPIEEENIRQLMFESKNGQSLPTKFISKVNGSWYSQVCGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNN6</accession>
    <name>A0AAV6TNN6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002205">
        <property type="protein sequence ID" value="KAG8172955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNN6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="159" mass="17697" checksum="266368629970B5E5" modified="2024-11-27" version="1" fragment="single">SRVKYAEGKANAFLQLGKRRIEMMGVKMCGACVHTRWTKKSSSGCMLVIKNKTFLAHAQYPLSTETAKRLLVKRKDESRQYTLIIGAAPISNDDTLSFVVCDNSIKDGGGKIETSGFNFPLRNTCRSKICIFGKTKPDGTFQIDLYCTVAIHKITDTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPA0</accession>
    <name>A0AAV6TPA0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001717">
        <property type="protein sequence ID" value="KAG8173478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPA0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13053" checksum="A5A7BD41DA200A43" modified="2024-11-27" version="1" fragment="single">MRALESEKQFSKWLLDVGNAKEGDAVKLPEICYPEIQDPIAQLYNDIDFRNVTSKQLKDRAILTVTNDIALELNKKVLSVLPGDEAIYEAADIIISDDPQDQLAYPEEFLNSLTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRN4</accession>
    <name>A0AAV6TRN4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001164">
        <property type="protein sequence ID" value="KAG8174705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRN4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="8835" checksum="8C32FF72B2A54633" modified="2024-11-27" version="1">MNHDWTCGRGRSRHPPVNQTDDQKIAALMRPRQPQTVCLRVCFVTSSFGNPRVKGNPGQTLAAPLTIPRPITRGILLDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRR5</accession>
    <name>A0AAV6TRR5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001222">
        <property type="protein sequence ID" value="KAG8174426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRR5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="242" mass="26424" checksum="4F9E1DA769848AB8" modified="2024-11-27" version="1">MSGGLMKWRFAFACSFINFTVLAQIRIAGLQFVATLERYDVSRSQAAFPYVLRYIVAFVCGSFIGFFGCKFGLKPVTLSGCCLLSFGIGLCFFAEDVIVITIGWGLFNGLGSGMACHLLPSYMSLHFAPEDLARANGLAMTCSKAISRPALQNKTKYFRKSSGLYSPTFILMTIIQSSFMCIVTLHLTVLVDFAKDKGVTTDQSVHMLMCSAVANLAGCLTLGFVTEKLWLSATQFAALCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTZ4</accession>
    <name>A0AAV6TTZ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_018040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010001023">
        <property type="protein sequence ID" value="KAG8175360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTZ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="446"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8175360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="710" mass="80990" checksum="F68CAA5C2DBC6574" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVH1</accession>
    <name>A0AAV6TVH1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001012">
        <property type="protein sequence ID" value="KAG8175397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVH1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="54"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="183" mass="20898" checksum="918C5AF2A766330D" modified="2024-11-27" version="1">MSVRIVLSELRSNFWILRGRPVFKRALHNCLPCKVARAKCDKQIEAPLPAERLTPCKPFDTTGIDFAGPVYVRGANAPKKSYIALFTCSTTRALHIELVADLTTDTFLMALQRFVGRRRLPHTTYTDNATTFQDANKELIALWNSLSSTNAQQFYAENGIRWKFIVPRAAWWGGWWERLVGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVN3</accession>
    <name>A0AAV6TVN3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000948">
        <property type="protein sequence ID" value="KAG8175804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVN3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="8644" checksum="C8D7109BC719BD41" modified="2024-11-27" version="1">MEVRNSERPIHSVFVAIYQSSFGISLKTRVFQVRVGSPCLETFTNECPPGSVLSVVLFILKINGIVEQLSPAVKDTCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVP9</accession>
    <name>A0AAV6TVP9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000928">
        <property type="protein sequence ID" value="KAG8176017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVP9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26173" checksum="77F47EFB0CC9919A" modified="2024-11-27" version="1">MKHQDGKISESLSPRGEMKIEDQKQDGKTQATNRVDVQPILIEEGAPHILTAKISVPVSTPIDNKEKINELKKISLKYGANVIEGIVDTGAQILVIRADLISDLLFDGAGKIKIVSAFGETELAQLKVIHMKINDGCHGEVPITCAISEKLVSWTLVSWSAFEALNANIELFGSEFTSREVEEEPHPVALSNEISSTGKDKTWGKRRLFVQLQQEHDTLKGAWDLACEKKENFGVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYW3</accession>
    <name>A0AAV6TYW3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_024923</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000874">
        <property type="protein sequence ID" value="KAG8176495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYW3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990508">
        <property type="term" value="C:CKM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20514">
        <property type="entry name" value="CYCLIN_CCNC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000015">
        <property type="entry name" value="Putative cyclin-c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000017">
        <property type="entry name" value="Putative cyclin-c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="11">
        <location>
            <begin position="46"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="11">
        <location>
            <begin position="157"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8176495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="292" mass="33831" checksum="7F41B55E887DF893" modified="2024-11-27" version="1">MAGNFWQSSHFQQWLLDRQDLLRERHNDLQIFPEEEYQKLMIFFANFIQALGEQLKVKQQVIATATVYFKRFFVRNSLKCIDPLLMAPTCIFLASKVEEFGVISNSRLITTCQTVVKNKFSYAYAQEFPYRIAQVLECEFYLLEMMDCCLVLYHPYRPLIYYVQDIGQEETLLPMAWKVINDSLRTDVCLLYPPHQIALACLHMACVILGKDCKQWFAELNVDMEKILEITRQILSLYEAWKQFDEKKEVPALLAKVPKPKTQPTRPPSQGPGGTSNDPNNPVTCQPSAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZ02</accession>
    <name>A0AAV6TZ02_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000830">
        <property type="protein sequence ID" value="KAG8176999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZ02"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="204" mass="23431" checksum="84DAD567C7ABB0CE" modified="2024-11-27" version="1">MSTDAAEFVKEKLVFSLKDIWELEQQTISQSESSLWKEQRKWRLTASNFYKVCVRRKDHTKLVSALLSSHSSDLSRIPAIAYGNKYESLVRTQIRSQYPNSLVRKVGLVTHPAMPHLAASPDGLIHNGSNTMLLEIKCTFNVDRLELEELAERSNFCLVKTEGQWELKRSHRRPPSKKNFTQIVSTAIISGDLFFIFCRVCNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZ72</accession>
    <name>A0AAV6TZ72_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit beta type-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_024250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000864">
        <property type="protein sequence ID" value="KAG8176589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZ72"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8176589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="205" mass="22937" checksum="A4925AB7B60C97BF" modified="2024-11-27" version="1">MSISEYNGGLCIAMKGKQCVGIAADRRLGVRAQTLAMDFQKVYEMGPRLYLGLPGLATDTATVAQKLAYRLNMYELREGREMTPKVFSSVVSNLLYERRFGPYFVNPVIAGLEPGTWEPYICNMDVLGCRDEPQDYVVAGTSEDQAHGMCEALWEPDMEPDVLFEKISQALINAFDRDAIAGWGGIVYIIEKDKITTKTLKTRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZV3</accession>
    <name>A0AAV6TZV3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">lysozyme</fullName>
            <ecNumber evidence="4">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_026730</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:60648"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:143891"/>
            <dbReference type="ChEBI" id="CHEBI:143892"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000792">
        <property type="protein sequence ID" value="KAG8177284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZV3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16890">
        <property type="entry name" value="lyz_i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008597">
        <property type="entry name" value="Invert_lysozyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF103">
        <property type="entry name" value="RE10370P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05497">
        <property type="entry name" value="Destabilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51909">
        <property type="entry name" value="LYSOZYME_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="7" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="51"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="56"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="105"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR608597-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8177284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="651" mass="74359" checksum="B4FF8F77D2CF3A7F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZV8</accession>
    <name>A0AAV6TZV8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-binding cassette sub-family D member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_006523</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000825">
        <property type="protein sequence ID" value="KAG8177047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZV8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF59">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER ABCD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="145"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="388"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8177047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="68892" checksum="66B19478B446F620" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3E0</accession>
    <name>A0AAV6U3E0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Microtubule-associated protein Jupiter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_003462</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to all microtubule populations.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAP Jupiter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000670">
        <property type="protein sequence ID" value="KAG8178740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3E0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033335">
        <property type="entry name" value="JUPITER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34930">
        <property type="entry name" value="GEO05313P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34930:SF2">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN JUPITER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8178740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="258" mass="27124" checksum="C4F9A04A0CE9306B" modified="2024-11-27" version="1">MSEPIERKVCSLGTPFISTEMNGVPSKPVPGDILPCDSSDDLFILLRKRHVELDKIGRGKRIVKPPGGECSDIFGASPATSPNGEHPSTPRKSNKSFMLHSNIFTPPDSTDSTPTSPNGTNGKLLDTTVRLFGGEVQNETPRKVVDRQRSSIFEDEVDSSSRPGSVKNTPARKPQINPITGIPIHENGTNGHSNGTNGVHSNGGTPNGGTPNGTHSNGGTPNGHSNGYSNGHTSPDSPMNGSARAYRNPPGGKSSGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U531</accession>
    <name>A0AAV6U531_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_004062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000643">
        <property type="protein sequence ID" value="KAG8179234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U531"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8179234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="388" mass="41788" checksum="9FD22205AFE883E9" modified="2024-11-27" version="1">MMTASDKCASLVTPPLPASPSPTVFLTPHTHRYPSPNPVPVLVSPTSSPGPLGLTDEQAPRTRSPSAPSPSPTRCIPTVFHAENTFPPSLTNPSSSLPLDPSWSLTFSPSLSQKATFPRAKSPSLTQRPETSPVTVQDSTPTVATTHLPEPPPPSISLEETTNGTAELPPEPSMSTSSSSSIVERTVELQPLPPSPNPATDVIDLTGSPKTRPHPPLIEEDWTCGFCEVHFSSRMECDAHLSDIHLLSQEKVELSPPRDAKHEELPKSPALRDSPLVPTLVEPDNAQFNIFNTPLPPKSKLFRCQSCGLQFDQYQRFRTHKLTHQKTPFPSFPSPMTTTATTHAEPPTSASIFTTRGDTAPLARPSKPASDATKSSAIILPPPTMMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5X7</accession>
    <name>A0AAV6U5X7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulator of rDNA transcription protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000643">
        <property type="protein sequence ID" value="KAG8179218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5X7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13539" checksum="593166EDF520713E" modified="2024-11-27" version="1">MNAWLPRVSYPCSNSSDTSCIKLVKSKGLIGPAFAVRIHTENQDQASFCPFALREVSVLAELALGHLRYHLTDVPPQPNNPPESVLGADRALQGGSALGARSVILTGRFPLNRVSKETMKAVVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U828</accession>
    <name>A0AAV6U828_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_016356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000593">
        <property type="protein sequence ID" value="KAG8179983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U828"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026642">
        <property type="entry name" value="Glcci1/FAM117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14972">
        <property type="entry name" value="AGAP011572-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14972:SF8">
        <property type="entry name" value="GLUCOCORTICOID-INDUCED TRANSCRIPT 1 PROTEIN-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15388">
        <property type="entry name" value="FAM117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8179983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="421" mass="45152" checksum="2231E4512265871C" modified="2024-11-27" version="1">MSGQPSQSQRMRKTVSPGAGSKQGPIRAIVPLSLMQTCSPTRCLKTTASPTRCLKTTASPSHSPPVTWASGDAASKVKTRLSPDNRISPSESSQSPSPICRGGDGKSSKMGGGGGKSSVSPSFLRRTASVDTIYLLGQWQRDALYLSYCGRLMMDRATQTPDEFEEADRRPSQKKGSAASNETLEMKYIRQRLQRGPVGGRPHPPSSGGSTSPPSVPSFAPPPRAHPIPIPDIPKLIPRMRSSVEGLNQEIERIVLREISTAEGDDNDRPMAPTPEGHRAPAPHQQQQSVDTQTPLDRSSSNSSTSSGSPPLAPLLPMDSLSRPSSTEGSKGSGSPDIEGTHKLATSPHINKFLAREPPDGCEKVKIAEETRSCEYQHQELSKPSMHHFVLLPSQRSAFDPLCKTCGALSNGDVPQNTMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9J0</accession>
    <name>A0AAV6U9J0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000539">
        <property type="protein sequence ID" value="KAG8181012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9J0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="240" mass="27496" checksum="11AEE87D6B50F725" modified="2024-11-27" version="1">MVNARLVYCLEEKGAFSPFQSGFRHHRSTIDNILLLETSIREAFIRNQHLVSIFFDMEKAYDRTWRYGILKDLYHLGFRGNLPVFIQNFLKTRVFQVHVRSTLSRDFYQREGVPQGSVLSVVLFILKINGIVEQLPPAVKGTLFVDDFQISCASTNMSTVERQLQIAIRKITDWTNNNGFVISNQKTICMHFCRKRGLHLDPEIILNGVALPACHVYVATGTESCKFLFVILMSSIASQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9W9</accession>
    <name>A0AAV6U9W9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_024443</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000531">
        <property type="protein sequence ID" value="KAG8181147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9W9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17335">
        <property type="entry name" value="MFS_MFSD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF30">
        <property type="entry name" value="SUGAR BABY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="39"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8181147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="452" mass="50938" checksum="38644AD13E742E28" modified="2024-11-27" version="1">MSLEKKENVINICISPTKPPVAEKLPVTKTFWNINKEMLRFKIHFFLFLGGLAAGVPYVIVLAKNRIGISASSLGVVLTGQMFLFIFTKPIIGYLADYYNKLKEIISVLIDETLSPTPVTELECISCDFLKQTRETPSFRKKDYQTYQFWLFSMLDTISAICLSGIFTLSDTACFESIQKHRGDFGKQRLWGNIGWGFVALLAGFLNDYTNDFLAAYVLMGILLSLFLWNISKIDLVKPHYSKNILKDVGTVLRSREFLFFEVVIFCNGIGTGIIWYYLIWFLNSIGGSELLIGLSLTVQSIVGGIPFMFFSGWFIRKFGHFNLLVVSMAAYGIRFLWCSYLQNPWWILPVEFLHGINYGLYYTVLGSYAKLSAKPGTEATTQAILSSTHEGLGAGFGCVLSGMGFDYFGGRQTFFYLSIFCMCAVFNGIVFSAYLQTRKGEAKFTSPNEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAM7</accession>
    <name>A0AAV6UAM7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_022212</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000523">
        <property type="protein sequence ID" value="KAG8181274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAM7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045089">
        <property type="term" value="P:positive regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12219">
        <property type="entry name" value="Ubl_TBK1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000100">
        <property type="entry name" value="inhibitor of nuclear factor kappa-B kinase subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000106">
        <property type="entry name" value="serine/threonine-protein kinase TBK1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051180">
        <property type="entry name" value="IKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041309">
        <property type="entry name" value="TBK1_CC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041087">
        <property type="entry name" value="TBK1_ULD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969:SF15">
        <property type="entry name" value="FI05319P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969">
        <property type="entry name" value="IKB KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18394">
        <property type="entry name" value="TBK1_CCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18396">
        <property type="entry name" value="TBK1_ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="12"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="691"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8181274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="782" mass="88602" checksum="83FA67A63484DFCF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAR6</accession>
    <name>A0AAV6UAR6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_004675</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000553">
        <property type="protein sequence ID" value="KAG8180716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAR6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8180716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="131" mass="15122" checksum="834A1026AF16A58A" modified="2024-11-27" version="1">MAATNCACPTERERGKLFRFMPRPYYYSCSFHPPRVLSLTDRSCAANDTNCKLELDRQDILLYFIFNQFEVTTFVHEPKFEKVSLFSYIGGYMGMWLGASLVALFDLAETLVNLLVINPLSQSSRRKTRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAZ8</accession>
    <name>A0AAV6UAZ8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_007759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000520">
        <property type="protein sequence ID" value="KAG8181352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAZ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043608170" evidence="2">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="143" mass="16459" checksum="D294829B1426182D" modified="2024-11-27" version="1">MNNQFLFTLFFVLAVTTIHCRETNSNNKEGEGDSDSPTDSPPSSWWSGFKARVKSVLSRWKEDIKLLWDDAVEKARDMKGWTSEVLDSLKVKLREWVETRKELPDDEKNEIETFISKLKVPTDAPGGERKIDKKIDLSLREVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UB52</accession>
    <name>A0AAV6UB52_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_001998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Venom protein that causes edema, enhances vascular permeability and is likely related to the inflammatory activity of the venom.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000562">
        <property type="protein sequence ID" value="KAG8180466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UB52"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="TCTP" evidence="6">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00055581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8180466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="173" mass="19617" checksum="53FF4A430426FC55" modified="2024-11-27" version="1">MIIFKDLITGDEMFTDSSKYKLVDGCLYEVECRLVSRKHGDVHIDGANPSQEEGDEGTDEVVESGLDLVLNQRLIETGFTKSDFKNYLKTYTKTLQDKWKENELTDEQMAEAKSKFTEAVKKVLPKIGDLQFFMGESSNPDGLIALLEYRETSDGGETPIMIFFKHGLDEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UC07</accession>
    <name>A0AAV6UC07_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000508">
        <property type="protein sequence ID" value="KAG8181544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UC07"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7149" checksum="D41CB109C499936D" modified="2024-11-27" version="1">MKRAVRTPTIGALQQPPRKKHHRGSGFKDCCTIGGTRALVALSGQPSAHLHHNVPNGPCTERGAGDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UC46</accession>
    <name>A0AAV6UC46_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000505">
        <property type="protein sequence ID" value="KAG8181615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UC46"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="113" mass="12978" checksum="935CE7BEF821D0A1" modified="2024-11-27" version="1">MIIGIQTSSYPKPSSLHAKKLPLKWWNVIALVYLHLFSLKTVLAMFLTDGGLGFWMQLSTFLKSSFATVCADVYVMKRNKMHTLIRRISKLFGTITFDNKRKYLNAASKVLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCL2</accession>
    <name>A0AAV6UCL2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000488">
        <property type="protein sequence ID" value="KAG8181924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCL2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="145" mass="16739" checksum="C55D8EA2B809088D" modified="2024-11-27" version="1">MLGYRPFCFSESILGWDVRTDMVYEHKEPLNKNQGYQASMDHCAEPNNLPTLGGFLLSSKNQARGPEFLKYPLLAIYMEDFFYISGRGRPLHLFVQLLAYEMLKDVWQMRKDAYQYLSCLPGGVQLVNFDEGFCCANAEIREAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCQ6</accession>
    <name>A0AAV6UCQ6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thyroglobulin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_003983</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000493">
        <property type="protein sequence ID" value="KAG8181836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCQ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035592">
        <property type="term" value="P:establishment of protein localization to extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF25">
        <property type="entry name" value="SPARC_OSTEONECTIN, CWCV AND KAZAL LIKE DOMAINS PROTEOGLYCAN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043552012" description="Thyroglobulin type-1 domain-containing protein" evidence="6">
        <location>
            <begin position="32"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="32"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="93"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="130"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8181836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="157" mass="17832" checksum="B679111D999D0661" modified="2024-11-27" version="1">MFFPRLKHSPFPAMKTFSVLFVLCLAVAVRAQTQCEEHRERELKNDVSIKLIPKCNEDGDYEEMQCFQGDNPYCMCWHTDGTAITTPSKNLKTCACHNHRYRELLSSNEGMVGNFVPTCNSNGTYAKKQCHGSTGYCWCADEEGTRVSEEVRGELEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDW5</accession>
    <name>A0AAV6UDW5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000499">
        <property type="protein sequence ID" value="KAG8181700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDW5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043484855" evidence="1">
        <location>
            <begin position="30"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="174" mass="19050" checksum="8F1B0B66E5D54AB4" modified="2024-11-27" version="1">MSFYTVGKMNSKCLMLVFVLASFVIAAAGARDFKKRHAVAKRQTDSNSLFGFDFSFGNIFNLFINSITYVIKTALKVALNSALTALPVVAGKMNSKCLMLVFVLASFVIAEAGARDFKKRHAVAKRQTDSNSLFGFDFSFNNIFRLFVENITTIIKIALKVAINSALTALPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIU7</accession>
    <name>A0AAV6UIU7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">General transcription factor IIH subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor IIH polypeptide 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_025150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000413">
        <property type="protein sequence ID" value="KAG8183598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIU7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8183598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="260" mass="29028" checksum="4D9FF38776C069AF" modified="2024-11-27" version="1">MLNPSNKLAIIGCHTKESAFLYPQPSSTDVDDLRPSDGQYELFAKIKNAVNTNVKDLVERGISEEIYTESLIAGAMTMALCCILLKENSETLNIRAMKKQQILEKKLPARILVVTASGDSASQYMNFMNVFFTSQKEGILIDACVIEKDSGLLQQGCDITGGMYLKIQNVAALLQYLLWIFLPSVDTRKKMILPTRVHVDYRAACFCHRNLIEIGYVCSVCLSIFCTFSPICSTCQTAFKLGALPTILSKKKRKQVPLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIW8</accession>
    <name>A0AAV6UIW8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000377">
        <property type="protein sequence ID" value="KAG8184327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIW8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="175" mass="18961" checksum="003A8AECBE5157B5" modified="2024-11-27" version="1">MGREGAGPALRRRRDLCGKNGTRILTPVDRADVVAAASSATVYLTYGFPMVPSFFPDAAPLSFSVERILAPDFGRRPAEKGPSAEVKEDLMPEEDSCPASESSGDPWPVWVYCSRYSARPSSGESQLFPFLPALYPFNPIGLSSPQKLPTKSGLGPRCMSRRVESPLQTQHASTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJJ8</accession>
    <name>A0AAV6UJJ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.130</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Coenzyme Q biosynthesis protein 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_008975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the COQ4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.130" evidence="7"/>
    <dbReference type="EMBL" id="JAFNEN010000378">
        <property type="protein sequence ID" value="KAG8184289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJJ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8184289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="272" mass="30961" checksum="C0F07809FD9F4708" modified="2024-11-27" version="1">MANLLVNNLVLRPCHNLVKSVLSRRLCSNAVEHTNHENTSEYESHHNLYDAHIPTSTLQKVLLTLGSSVLSISNPYRHDMVAVLGETTGLKAAQQIRDKMMQDPEGISILHDKPRISSSSLDYQFLESLPKGTLGHAYLAFLKDNNVTPDTRRPVHYVDDAEIAYVIQRYREVHDFNHTLLGMPTNLLGEVCVKWVEAIQTGLPMCVAGALLGPLRLSAKQRQKYLESYLQWSISCGQQAKFLMNIYFEKRWQQNLDDLRKELNIPELPQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UM09</accession>
    <name>A0AAV6UM09_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SSUH2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000359">
        <property type="protein sequence ID" value="KAG8184818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UM09"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052789">
        <property type="entry name" value="SSUH2_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="51901" checksum="4C315092DDCB1C20" modified="2024-11-27" version="1">MAKTTSLELPHLDIISAEPDELDIFSESQIMDSISPESQIMDTISPEPDIMDSISSEPRLVDVISPEQFVRRSSYRRSVTPSRGGVGTRGTGSYKRQTSCRVTPPPDAIDDDLEPSAPPLELMDKVRGYESASFEAIAIPPPLLTSPQKPEGENPRSPLPSIPHLTEKQARDALIKQISSHCCYGTGAARDMAITEIKHSLAFHYTLETFTEKRTTCWAYEPYTGGAIGKSKTGEAPFAWDVPAKPPTYFKNHASELEVPFTASVKICHVCGGVGRKRCNTCSGKGWSSCFHCHGAGVNPVAIRTEAKECLHCTGSGQRKCWKCNGDGMAVCKACSGTGQIKCFIRLTIKWTNHMDDHVVDQVGSLSDDKIRSATGEVVCQEEDISLLPLTHFPDTTVSMASAQLLQKHENEVPDEKVLKQRHQVSIVPVTALSYKWRNREGQFHVYGYEQRVYAPKYPQKCFCCCCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UML7</accession>
    <name>A0AAV6UML7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_002333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000372">
        <property type="protein sequence ID" value="KAG8184486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UML7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8184486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="389" mass="45219" checksum="136F18C63287196E" modified="2024-11-27" version="1">METVLRGLSYEACLVYLDDIVIVGKEFNDHLINIRKVLTKLRYAGLKLSLSKCHFFRREVKYLGHIVSSAGVQTDPDKTEAVNNWPRPKDVHELRSFLGLSTYYRRFVKGFSMIARPLHRLTENQQKFTWTPECDEAFDHLKSILTSAPILAYPEPDKMFILDTDASKEGIGAVLSQEVDGKERVIAYFSKSLSKPERNYCVTRKELLAIVKAVEHFHHYLYGRRFLVRTDHASLTWLLNFKFPEGQIARWNQRLQEYDIKIEYRKGSSHGNADFLSRRPCPETCKHCTNAESKYGYEQPMVRLVNISSLPDPDPWSDAGMRESQLEDQDLRPILESLEKAEGRPSWQDMASYGPVTNRYWALWDSLKVHNGVLYRKWESDDGKSFRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UN54</accession>
    <name>A0AAV6UN54_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000346">
        <property type="protein sequence ID" value="KAG8185128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UN54"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8457" checksum="79AE7025D6501B46" modified="2024-11-27" version="1">MLLGKCRLLSDYAKTPCLLSSVDEAWWKLYWWIGMELKRGWKSVTCTSVEKRCISHVIPIEDTPVLLQRAGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPC0</accession>
    <name>A0AAV6UPC0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_010714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAFNEN010000320">
        <property type="protein sequence ID" value="KAG8185927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPC0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000632">
        <property type="term" value="P:negative regulation of pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF1">
        <property type="entry name" value="RNA 5'-MONOPHOSPHATE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8185927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="246" mass="28386" checksum="310F71CBACE9D292" modified="2024-11-27" version="1">MTTQSNELNEVKPFHPGAARFGNFINYYNFNSVSKRLNPIPSEFISNLTLNSNSVLCLDIGCNSGELTSGLYTYLVSNAKGNAEIFILGIDLDDVLITRCNESNPHPNNITFQQIDIMEETAMTQLKSFLDAHKRSEFDLVTCFSTTMWIHLNHGDMGLDRFLKKISTLSRFFILEPQEWKSYKSAVRRMTRLETEVFELDKLKIRDISSHVSEFLRNKCGMDSSECWGVTSWGRNLYMFHKRCYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPH0</accession>
    <name>A0AAV6UPH0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000311">
        <property type="protein sequence ID" value="KAG8186162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPH0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="33967" checksum="9A8DEDCCFAF03F8D" modified="2024-11-27" version="1">MISIAVYLVAFYISYCVLFIGNYICGMRWREVMSWAVYLIWEIVFYYGSERDFIKQLSIDLIGIYYLNYLMIMVIIGPFCVQLNKDIHEIIWKQFLYPIKYLVKKIRVSGISEKGEMIMDMTKLKIQKIRSYWYYNKKRFLPPLALKLLSILVDVIWFLILRPILGILFWLLKRFWIDSVFFIKLLLDFLGWEQNIDRRVGFRQRSSRRIVIFDRTSICRAMVQEDAFNSQIRRLIFLYNARDFFPDFEYRATNYDTAVNIAVWGLKYLYNAYIYKLFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ44</accession>
    <name>A0AAV6UQ44_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">WD repeat-containing protein 82</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_020858</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000297">
        <property type="protein sequence ID" value="KAG8186555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ44"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032785">
        <property type="term" value="P:negative regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071027">
        <property type="term" value="P:nuclear RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000065">
        <property type="entry name" value="WD repeat-containing protein 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8186555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35526" checksum="DD2B54E1D0720E3A" modified="2024-11-27" version="1">MKLIDHVVRSFKVAKVFRENTDRINSIDFSRNGETLISSSDDESIVIYDCERGTHKRTTHSKKYGVDLIRYTHAANTAVHSSTKVDDSLRYLSLHDNKFIRYYQGHTKKVVSLSMSPVDDTFMSSSLDKTIRIWDLRSPNCHGVMHLTGSRSVVNYDPEGLIFAVGLNSEMVKLYDLKSFDKGPFNAFKLPQDKGCDWTGLKFSPDGKTILISTNGHNIHLIDAFQGTPLHEFTGHVNNKGIPLEASFSPDSQFVFSGSTDGKIHVWSAETGLKTCELFCDHTGPVQCVQFNPKYMLLASACTNMAFWVPTGENDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UR12</accession>
    <name>A0AAV6UR12_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine 4-monooxygenase</fullName>
            <ecNumber evidence="3">1.14.16.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_020847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000297">
        <property type="protein sequence ID" value="KAG8186544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UR12"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF24">
        <property type="entry name" value="PHENYLALANINE-4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="8">
        <location>
            <begin position="198"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8186544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="276" mass="31608" checksum="E9816D22C2EB9871" modified="2024-11-27" version="1">MLKATGSALPDVNGMDMEKLIKKEPLTRKWSLVTDAKLETAIHKAAQESWKKNLIKDGALDYELTEEEILLLSRIPKEQTHGKMFVSLIFSLADEFSTLPLILQNIELHNGRIKHLETRPSKRSDGSLDLLVKLAVEQKGLLNLIKTIRQEENIPVSIVADETIFLKDVWFPKCIGDLDKCNRILSKFEPDLDSSHPPIPLVHYTDEEIKTWSLVYKKLHQVFPKYACAPFLRSFQLLEKECSYGADAIPQLQDVSAFLNRLLLWLIFFNILALEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USZ3</accession>
    <name>A0AAV6USZ3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S8 pro-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_014760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the meteorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000294">
        <property type="protein sequence ID" value="KAG8186686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USZ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051998">
        <property type="entry name" value="Meteorin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28593">
        <property type="entry name" value="METEORIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28593:SF3">
        <property type="entry name" value="METEORIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043966949" description="Peptidase S8 pro-domain domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8186686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40189" checksum="EE0C08D894F088BA" modified="2024-11-27" version="1">MTISNRTLKYLLVLIVLNALDNINASGVYSDQFVIKVPGGSEIAKQVARDHGFEYLGEDSVFALVSEKGCACGIGDDRVGEMLFSVFSSFFISVVLILNNVRKVCGQASDTCDWVGSGLLQNETRGVQPLYLRCTQGRIKWHYPRGALRALLRPPLPSFRGCVRISGNSTGARLFLEGKGRLHPLYKGSRDRRSEDLHRCFTSRGGQVALYVEADPPLDILRKDTIEFKYDLVAQENLADDMEECRPCSDQEILQSYCTSDFAIQGTVSALNHNPSIQTSELTIRVSSYKTSVPHRTDPKKYVTLHRPLKCGTKAGEGQFLFLGRWVLGRPAVRCAPRLSHWKEIRRKAIEADTNLCQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UW37</accession>
    <name>A0AAV6UW37_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_002427</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000257">
        <property type="protein sequence ID" value="KAG8187883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UW37"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000720">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000016">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043518331" evidence="12">
        <location>
            <begin position="17"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="590"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8187883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="649" mass="72156" checksum="30E72AED53CC7357" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UX33</accession>
    <name>A0AAV6UX33_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000239">
        <property type="protein sequence ID" value="KAG8188368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UX33"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043574431" evidence="1">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="160" mass="17671" checksum="83356D3F1C259B7C" modified="2024-11-27" version="1">MNIKQAFLCTLLGIVSSGPFLGLIQQAADEAQLMMRDEGLLGQTINSGLKVLNGEYYKKLWQNELKRMLVSALRQSRGENRRTMLKALATFARLQKRNASPGEIVASIRQILGDVWKTKVVKDSIGSNVNPSVDFLNHSSDIIRSHREEVLSSTAGSVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0R6</accession>
    <name>A0AAV6V0R6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_022497</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000207">
        <property type="protein sequence ID" value="KAG8189683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0R6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002326">
        <property type="entry name" value="B-cell CLL/lymphoma 6 member B protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002529">
        <property type="entry name" value="B-cell CLL/lymphoma 6 member B protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="531"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8189683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="691" mass="80025" checksum="D26DE25019DF156A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1B9</accession>
    <name>A0AAV6V1B9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000181">
        <property type="protein sequence ID" value="KAG8190540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1B9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="737"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="775"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="805"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="843"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="2">
        <location>
            <begin position="245"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8190540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="875" mass="100010" checksum="8240CFA711D92450" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1X6</accession>
    <name>A0AAV6V1X6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 2 subunit 2</fullName>
            <ecNumber evidence="3">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Eukaryotic translation initiation factor 2 subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_005818</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the poly(ADP-ribose) glycohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000174">
        <property type="protein sequence ID" value="KAG8190782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1X6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990966">
        <property type="term" value="P:ATP generation from poly-ADP-D-ribose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048362">
        <property type="entry name" value="PARG_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
        <property type="entry name" value="POLY ADP-RIBOSE GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF15">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20811">
        <property type="entry name" value="PARG_cat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="12">
        <location>
            <begin position="918"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="739"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="793"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="811"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8190782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1052" mass="119672" checksum="409F565F4CAE51C9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3N4</accession>
    <name>A0AAV6V3N4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_010028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000166">
        <property type="protein sequence ID" value="KAG8191104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3N4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CAP_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043563378" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8191104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7571" checksum="45043C7A1E9D24FC" modified="2024-11-27" version="1" fragment="single">MMNLLTVFGVLLCALQCYSQCSPQVRGVNQSARQTILNKHNQLRAKVANGQESNRQGRLPQASNMLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3T5</accession>
    <name>A0AAV6V3T5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_017891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000179">
        <property type="protein sequence ID" value="KAG8190628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3T5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06713">
        <property type="entry name" value="PDZ_tamalin_CYTIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052122">
        <property type="entry name" value="Intracell_Traff_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15963">
        <property type="entry name" value="GENERAL RECEPTOR FOR PHOSPHOINOSITIDES 1-ASSOCIATED SCAFFOLD PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15963:SF5">
        <property type="entry name" value="SHORT SPINDLE 6, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="74"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8190628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="362" mass="41135" checksum="B291F1CA97059AA9" modified="2024-11-27" version="1">MFVGGGMASPKTTKKHTKKHRRHHHHHHSHHHNFHPPQDLQLSNLEASQHQILETVKNDRVIVTQPEEDRRRRTIIVERKNGSFGFTLQTYGIHHKRDGEIELITYVDYIEYDGPAFRAGMRPGDVILSINGHDMEKVDHKELVKYIQSCEKTMRMVVLFEDCVHKVELHMKYLRLKRLFQEKKLELEQLCDKEQQLIQNFKERGVHIPPSPFLVMRAPPTTSADDTLSCYHFPTIASSRKGYKSHAGTAHASPVIVPKQFATLPKAAGAVRRPWPTVHNPSSLHPGQHPSYHSSPKGSWDGLESQSSTGLSESTDFSESSSQGGHSPELSRKSGNKSESDLPDIAQDDDGEEEDRDEVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4T3</accession>
    <name>A0AAV6V4T3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000152">
        <property type="protein sequence ID" value="KAG8191775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4T3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8148" checksum="8750B6CFD3CAE668" modified="2024-11-27" version="1">MFCFRGSRFLGPKIKAIKTTIDSIGSEIGPMIGRISRKNSLSSTSSIPWAKESDRNHLRVEGGFWGGSSDGFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V652</accession>
    <name>A0AAV6V652_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="9">3.5.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_008829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>AMP + H2O + H(+) = IMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.5.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="9"/>
    <dbReference type="EMBL" id="JAFNEN010000153">
        <property type="protein sequence ID" value="KAG8191766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V652"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001251">
        <property type="entry name" value="AMP_deaminase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8191766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="782" mass="90116" checksum="DDF828F123FE4938" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6F6</accession>
    <name>A0AAV6V6F6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000153">
        <property type="protein sequence ID" value="KAG8191732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6F6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="124" mass="14458" checksum="AA8DE1035DB778CC" modified="2024-11-27" version="1">MPSRQQRSQVSKNLNNRRIDFGFQIFAQTHRPISIRLGYKLSKKRTRRGKEPFLEITRKLRRSKKMSGEDGKIEKVVPEGTLPGVETTLNRNGIEFFSHSVRRHGGMEIADIKFLKNKDVKKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6Z2</accession>
    <name>A0AAV6V6Z2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_012354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000155">
        <property type="protein sequence ID" value="KAG8191638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6Z2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12414">
        <property type="entry name" value="RRM2_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12415">
        <property type="entry name" value="RRM3_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12416">
        <property type="entry name" value="RRM4_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000182">
        <property type="entry name" value="RNA-binding motif protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="38"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="249"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="397"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8191638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="651" mass="74041" checksum="673972235617D30D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V726</accession>
    <name>A0AAV6V726_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_008784</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000153">
        <property type="protein sequence ID" value="KAG8191720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V726"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="12">
        <location>
            <begin position="15"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8191720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="143" mass="15528" checksum="CF279BF5F2BE3E4E" modified="2024-11-27" version="1">MTSGHLRIAILPTGPFSVSLTSSGEVTIIDGFEVGLLQMLTRGLRMPYTLHVPPDGTWGAPSATNGNWSGLIGMVQRNQVDMAIGSIFVSEARMSVVSFSYPYTWQDITFATRMPAVHPKGMAFTWPFECSVWISLGVTIIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7J0</accession>
    <name>A0AAV6V7J0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alanine transaminase</fullName>
            <ecNumber evidence="8">2.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_009689</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-alanine + 2-oxoglutarate = pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:19453"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.2" evidence="8"/>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7J0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000151">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="66"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8192659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="468" mass="53892" checksum="A544781155D5BF6B" modified="2024-11-27" version="1">MEENNKMGYIPILRTDTINQSFTRFEFPWPSLLVDRANELREEIRKILSLCMDPSLLQNEDYPSDIKQRAATILENCIGRNIGSYSRPWGLEIVRKQVAKYIQQRDGVPSDYEDIFLTPGATDALRILLYLLSYKDESDKPAGVMVPIPQYPLFSCTALEYGMYQIKYYLNEDTDWSLDVPELQRAINASRIHCKPKVLVIINPGNPSGFVLSKTEIQNIIKFAYEENIFILADEVYQDNVYDSDVEFLSFKKILFEMGHPYDQMQLASVMSGSKGFVGECGTRSGFCEILNVDSEVKDVLKKLACIRLVQNIPSQIVTYCQTNPPQPEEPSYKLYFMEKKLILNSLRERAQFCYEKLNSVPGLSCRRVIGAIFVYPRMHLSQKAVKEAQARNQTPDEFYAMELLENHGVCVLPGCLFGQRTGTYHFRMPFLSQMDTLTVIVEKILCFHQSFMEKFKDEIFQTSNTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7J2</accession>
    <name>A0AAV6V7J2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_016475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000154">
        <property type="protein sequence ID" value="KAG8191688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7J2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09941">
        <property type="entry name" value="SH2_Grb2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="60"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="157"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8191688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="328" mass="37531" checksum="8283131FDA84B94C" modified="2024-11-27" version="1">MEAVAKHDFRAADKDELSFKKDQVLKVLNMEDNEHWFIAELNGKEGFIPSNHIHLNSPEWYFGHTTRLEAEEILMDEHVGSFLIRISVNSPRDFSLSAKFPDSVQHFKVLRHPKGKFSLGRTKFNSLNELVEHHRTESVSRSHDVKLKDMDPEKEKDELFLVQAKFDFEPQEEGELEFSSGDVIRVLEKHDQNWWEGEVRGRKGCFPVNHVKPLEESRLKTYYNSIDALKHFGSVKSLEVEVDGDATSHQASKVISTLKIELDIKCNKTSCEELRTTILHTAWKISGGIAKKSESDPENSDNTKIEADEVVTHHQEPKLVSTSKSTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V908</accession>
    <name>A0AAV6V908_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_006971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000128">
        <property type="protein sequence ID" value="KAG8193139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V908"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="20"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8193139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="531" mass="59934" checksum="3B34E7B1AB513727" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9C3</accession>
    <name>A0AAV6V9C3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000141">
        <property type="protein sequence ID" value="KAG8192333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9C3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="473" mass="55354" checksum="0067FDD6A5D12952" modified="2024-11-27" version="1">MSVSLTSSESDNETAPKKRRRNEEKFERNVIIEHLKFVGLNTSTGKGISSHLDQQVLLFKSKDEQDIFLQQLIEKHAIKHRRPRSEQPRETAASFKYFLLYRGERKNVCKKAFYSLYGITEGRVRRLTDLLIKGESPHDKRGKNPKKNTISAEVCSKIHEHISSFPTKTTQYGTKDISYLDARLDVKKMHSLFKEKYPDLDAKYEFYLNYFHDNFSLRFGRPQVDTCIKCEECDVKIKSSSLGDAAKRDARAELTVHKRRAKKFYNKLQKDTKLCAEHEDTVALSFDFMQNLPLPAIPVKDIFYLRHLWVNCFGIKNLKTGKSEIFLNHEGVAHKGANDVCSMLLKYIDTNIPSSNRNHTMIRFCLALTDTGRFEQIFHYFPVRGHSYLPNDRDFGTMKRMIRKHDRIYTPDEYEELCAQSSNNFHITKLLTSDIKDFDGWWKEYYTKKTISQRMPREECAKRSKIQVCSHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VC75</accession>
    <name>A0AAV6VC75_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000109">
        <property type="protein sequence ID" value="KAG8194107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VC75"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="307" mass="35426" checksum="7238520127BCDDE5" modified="2024-11-27" version="1">MQDNISKFKISPRKGSVKMKELDTSEWRFIEDDNRHFDPLQSKTQSTQHKDMCFDVVDQSIEQEMRETIIDDIRSVVTDKSNGENTLACKPEESNRSPKINRKENEEILTNLKEFKMETNPYLVLCNRLDEEEGIKMPSVEDKLKLAEDRLRVSVNNFCETCEELLETTDSSDTESSKVGPLLKPEAVHESFRPKVLEPGLLPPQTLSVSEFNKKPKARTTQNTELPSTKVQTRKKGTLKQGFYLPSDTLLTQDKIIDKLTPEEAELLNSTSTKAFLKFLEDRKKEPPKVLQDIQKKLQDTQKYEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCB1</accession>
    <name>A0AAV6VCB1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_024592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000106">
        <property type="protein sequence ID" value="KAG8194269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCB1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000238">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8194269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="455" mass="51769" checksum="E29B10B4143B2C68" modified="2024-11-27" version="1">MGDVDPYVAERYEVSKRLGKGAYGIVWKATDRHNKKVVAVKKIYDAFRNRTDAQMIKRGTLKEEWKHGFIISQLLSALAYIHSANVIHRDIKPSNILMNHSGELKLADFGLARSLEQTGEYSSDPTLTEYVATRWYRAPEILLGSKRYTKGVDIWSVGCIMGEILSGKPLFPGTSTLNQVERIMSALPHPMQTDIDSLCTGYAAFVLGRAANKPKRLLRNVLVNCSNEAHDLITKLLTLNPNHRLTAKDGLEHPYISKYHAQELPTELEKSVPPLCDDMKLSVDQYRDKLYEMIGESEERRQVSPMPPIHVPSFAEKKNEKRVFIKQRIFEEIPTIDERKEALLRNQIAKKQPMAPMARKTLTPPFLSERGKFSLGFKHPVVLRDQGSNSTPTCQTESHSEKRSADRKFGRRQYGNPCNQSYCSSAKSELQSYSQDLTYGTITVTALQALRERRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VD79</accession>
    <name>A0AAV6VD79_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000112">
        <property type="protein sequence ID" value="KAG8193967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VD79"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13647" checksum="B17CBCD7E39A4CA1" modified="2024-11-27" version="1">MSLRNKVLLYKSMIKPVLMYASPVWATAKKCHRKKIQTFQNKTLENITNAPWYVRNTIIHKDLEIDPIDSAILSASHKYFEAMGASEHNIAQIIKYDQFVEQVLKRPRMIHHDPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDI4</accession>
    <name>A0AAV6VDI4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein regulator of cytokinesis 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_003037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000109">
        <property type="protein sequence ID" value="KAG8194094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDI4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8194094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="70578" checksum="3CF814FB57044003" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEI2</accession>
    <name>A0AAV6VEI2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">15-oxoprostaglandin 13-reductase</fullName>
            <ecNumber evidence="1">1.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_027953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000091">
        <property type="protein sequence ID" value="KAG8195210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEI2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF3">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="46"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8195210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="373" mass="41144" checksum="84D735CD50AD53FC" modified="2024-11-27" version="1">MSQNHRMRLPEWPWNDQVIRLKNKGFKMASKPSSFKKLMVHELTTDFRKAVKIESVKMCQPQKEHVCIKVKYVGINASDVIVTNGTGYHISKTVPFGIGFEAVGEIVELGESVEELKVEQSVAFINPQTYAEYVCVPAKEVFPIPEATPRYLTMLVSGLTAAISLDKSGRITAGETVIITAAAGGTGHLAVQWAKAAECHVIATCSSKEKEDILKELGCDRIINYKKENVAEVLAKEYPKGVDVIWETVGGQMLVDCVKNLAVKGRLITVGSITGYKTEGKKDLPKLDASFLLEQLLYKSAAVQGFLFFSYKECFPTYFKYLCDSVQSKKLKPLIDTGISTAEGEFVGMEGIIRGVEYLHSGKNIGKVVSRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF52</accession>
    <name>A0AAV6VF52_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division cycle 40 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PRP17 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_003128</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000101">
        <property type="protein sequence ID" value="KAG8194657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VF52"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="280"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="410"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="510"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="542"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8194657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="575" mass="65391" checksum="C53670F298192D3C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFT7</accession>
    <name>A0AAV6VFT7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="12">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_029169</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Specifically phosphorylates the activated forms of G protein-coupled receptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12008"/>
            <dbReference type="Rhea" id="RHEA-COMP:11260"/>
            <dbReference type="Rhea" id="RHEA-COMP:11261"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="12"/>
    <dbReference type="EMBL" id="JAFNEN010000097">
        <property type="protein sequence ID" value="KAG8194878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFT7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05605">
        <property type="entry name" value="STKc_GRK4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000009">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000074">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000239">
        <property type="entry name" value="GPCR_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF28">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00717">
        <property type="entry name" value="GPCRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="15">
        <location>
            <begin position="59"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="185"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="451"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="533"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="567"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600239-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8194878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="609" mass="69752" checksum="9B360A93B22B8018" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGH8</accession>
    <name>A0AAV6VGH8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_027946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000091">
        <property type="protein sequence ID" value="KAG8195203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGH8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="118"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8195203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="527" mass="60018" checksum="561158669AF01848" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJC2</accession>
    <name>A0AAV6VJC2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJC2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="48"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="435" mass="48339" checksum="53BC3CFFFD9B4FAC" modified="2024-11-27" version="1">MAGSAHHSEPSAVRYFSQFEKEGYYKKDAVYLNAGAPGTELLRMLPPIIEAATTHLMQNELEGDAQLFQYGVENGNWQFRSFLATFLSEEYGDDTVCSEQIFLTGGASSGLWLVLSALFSPGSVVFVEDPSYFCALKIFSDHQMTVVPVKTDDGGIIIEDLKEKFAQHFSDTPEACSPPLRALLYMIPTYQNPTGSVLSDERCSKLITLVRKYGITVLCDDVYNLLHYDDSLVAPKRLFAFDNQSDSNYIGNVISNGSFSKFLGPGLRIGWIEAPKWIVDKLENFGVLGSGGGINTYTAGLITSLLALGKLKSHLEKLKTVFKMEATAQLLRDELPPGCTLKSPSKGGYFLWVELPEHINGSHLLPFAKKEYQVSFMPGHRASPTGSFTNYIRLCISFYPLDVLLSAVRRLCVAISEFESKSKENPLFWQEYVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VK78</accession>
    <name>A0AAV6VK78_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VK78"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="160" mass="17864" checksum="8D4BB9D7DC5CA306" modified="2024-11-27" version="1">MNEKVPPSRRVAGPLLFPENKDFLSNAITRGHDRTKNIHRTPNATADDATAHAQIPSCDSPNKQKEKSHVSSQSALKEVCFLKFPKLEKGGCGHHVGRKHIAWTIPFRKKGVCFSMKTHQIRQVDGEKMRNSKTRWGRGGVDGGCLLFFAAFLVGEENEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKA2</accession>
    <name>A0AAV6VKA2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_007502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKA2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF456">
        <property type="entry name" value="CD63 MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8197250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="232" mass="25746" checksum="2FADD0FA1409A0A1" modified="2024-11-27" version="1">MVKVGMNCMKYLLLLFNLLFVVFGIVLIVVGIIVKVKEVTVFGDTTYASMPIIIFLTGLLTFLLAFLGCCGAKKESIFKLSLFGILLLVLLICQIAGIAIAFANRRTMESIIKDNMKNTLKHQKKDAISSWNYIQGNFYCCGVDGPKDYLDDKLDIPKSCCKPGEDDCKEDKAFKDGCYDHLVSFIFSNMKIFGGVGGIIAAVELVSIIFTFCLVSYIRKDKQGPQMGFMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKA5</accession>
    <name>A0AAV6VKA5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKA5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="119" mass="13464" checksum="E7FEE818B3A1F957" modified="2024-11-27" version="1">MIEKDCNLLEESSPISSESIQDIKSSREEALHVMDILEVKTNEVLSFPNRRETHPVVVVVKVGKNHKFHTTKKVLCNYFRDISGTTWNSTTTSIVSLKVKLCVWTGLPTITIGKMLNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKY6</accession>
    <name>A0AAV6VKY6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_013821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000072">
        <property type="protein sequence ID" value="KAG8196336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKY6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043888141" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8196336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1146" mass="124755" checksum="A932C0F63B7AFF4B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM19</accession>
    <name>A0AAV6VM19_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lysosomal-trafficking regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_004345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000059">
        <property type="protein sequence ID" value="KAG8197078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF86">
        <property type="entry name" value="LYSOSOMAL-TRAFFICKING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="5">
        <location>
            <begin position="2530"/>
            <end position="2629"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="4">
        <location>
            <begin position="2633"/>
            <end position="2934"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3105"/>
            <end position="3146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8197078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3287" mass="374532" checksum="1B325020604AC4B2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMP9</accession>
    <name>A0AAV6VMP9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_007227</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000054">
        <property type="protein sequence ID" value="KAG8197488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMP9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000149">
        <property type="entry name" value="microtubule-associated proteins 1A/1B light chain 3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8197488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22365" checksum="1335D71658994C4F" modified="2024-11-27" version="1">MVSNSKPLHEVYEEFKDPGDGFLYITYASENVFGRRCDYLLERHSCAHCEKPIPWPKIVNVTLLPPTKTSPAQQRRKTFKERRSLAMRKIESLEILTKFPKKVPVIVEKSEREKSLPYLDRVKFLVPLDMTMSQFVGIVRARLKLNPSQTFYLMLEDHSLTTMSRYVGDVYGEHKDEDGFLYASYAAQEMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMX2</accession>
    <name>A0AAV6VMX2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_027596</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMX2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF12">
        <property type="entry name" value="RB-ASSOCIATED KRAB ZINC FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8196886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="191" mass="22708" checksum="BC8BEA72FE2CC40A" modified="2024-11-27" version="1">MEGVRYYKCLKCSKEFTRKDSLHRHIAKHRDVRVVHSCEVCPSTFSRKDNLQKHEKVVHADNTFLAGSPPKQKIGIYKCKVCSKEFVKKYFFLLHLEKHKEVRQGFSCEICGTTYSSIIYDLDDWKSLLDDQSHKCPKCFKEFTRKDSLKRHFQKHKDVREMFSCSYCSSTFTRKDTLRFHLKNFHGVLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNP8</accession>
    <name>A0AAV6VNP8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_011304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000058">
        <property type="protein sequence ID" value="KAG8197141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNP8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000004">
        <property type="entry name" value="F-box/WD repeat-containing protein 11 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021977">
        <property type="entry name" value="Beta-TrCP_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12125">
        <property type="entry name" value="Beta-TrCP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01028">
        <property type="entry name" value="Beta-TrCP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="196"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="236"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="276"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="319"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="359"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="399"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="448"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8197141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="504" mass="58085" checksum="3380294515F17EA8" modified="2024-11-27" version="1">MMSEEMPIMAPPSTTCLYGNYKESSPDYVRERDLCMQCFEKWSESEQTEFVEMLLSKMLHHQHSHVSSFLRPMLRRDFISLLPKKGLDHVAENILSYLDAKSLCAAELVCKEWYQVISEGMLWKKLIERCVRTDSLWRGLMERRCWIKYLFKPLPGEPHPDHMFYRRLYPKIIQDIENIETNWRCGRHTLKRINCQSENSKGVYCVQYDDNKIVSGLRDNTIKIWDRSTLECIQVLTGHTGSVLCLQYDDRVIISGSSDSTVRVWDVKTGELINTLIHHCEAVLHLRFNNGMMVTCSKDRSITVWNMVSPNEITIQRVLVGHRAAVNVVDFDEKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIESGACLRTLEGHKELVRCIQFDNKRIVSGAYDGKIKVWDLAAALDPRAPAGSLCLRTSVEHSGRVFRLQFDDFQIVSSSHDDTILIWDFLNGTPPETPALTLRSPSRTYTYVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNZ1</accession>
    <name>A0AAV6VNZ1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_021639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM179 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNZ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059010">
        <property type="entry name" value="TMEM179-179B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029776">
        <property type="entry name" value="TMEM179B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31056">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31056:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26158">
        <property type="entry name" value="Claudin_TMEM179-179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8198397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="199" mass="21582" checksum="7ACDF8220597173B" modified="2024-11-27" version="1">MAIHCQLLFSTILYCLVFISSIIVISTISYAKKSFTKCYLYLNKESGSTSALSCDLNLYVSGAATAYGLVMAIYHGYGTVVASRDSHIGRTMWVMPWLLLNGFVMVLMFICACVYSLGLHITCTEVSKAVKTGCSSEISAFLSTAVAEGAVWVSVALWVCLIGIEGIRLKRNRRAISREVYVDPTTSDVVSIGNVVSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP58</accession>
    <name>A0AAV6VP58_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-sulfur cluster assembly 2 homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">HESB-like domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_001543</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterotetramer; forms a dimer of dimers with IBA57. Interacts with [2Fe-2S]-ISCA2 forming the heterodimer [2Fe- 2S]-ISCA2-IBA57 complex; [2Fe-2S] cluster binding is absolutely required to promote the complex formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP58"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120510">
        <property type="term" value="C:mitochondrial [4Fe-4S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000006">
        <property type="entry name" value="Iron-sulfur cluster assembly 2 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="10">
        <location>
            <begin position="40"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8197612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="145" mass="16099" checksum="72E0DD23D1C195F3" modified="2024-11-27" version="1">MFINILKNSHISFTRRALSLFSYRPVVYFSSSADFDSKTQLQITQSCADRLKKIASEGSFLRITIDGGGCSGFQYKFDLDSKLQADDVCFDRDGAKVVVDQISLDFLKGSTVDYKEELIRASFTIAENPQAESKCSCGTSFAVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRM7</accession>
    <name>A0AAV6VRM7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRM7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="149" mass="18227" checksum="38EC3A4392B39515" modified="2024-11-27" version="1">MDYWDKSFLDLHIGVFHKKAEMRAEKLRKRKEAEEAEEKADELEEIGKQYDEWVAKRREEEIREEDAKRLEEDAKRLEEDAKRREEDAKRREEEAKRQEEERNEEAAKRREEKKKLYAANRKAKAAKRREEAKKMQPFEPLSKRGRPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS61</accession>
    <name>A0AAV6VS61_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_009333</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VS61"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1070">
        <property type="entry name" value="Zinc finger, BED domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8199485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="734" mass="83180" checksum="8E4127CC13A8130A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUK5</accession>
    <name>A0AAV6VUK5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sodium channel protein Nach</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_022164</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000025">
        <property type="protein sequence ID" value="KAG8199718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUK5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8199718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28951" checksum="5D0429B382C2D2D2" modified="2024-11-27" version="1">MYLETKNKFNKKSGIFKKKIKDHSRRRKQRSAELSLLADFVANRLSAAGVSHVVKARSPIRRWFWLCTILITAALMFSMTYSVLKEYLEYPSIMRSKSVMVKELEFPAITVCGLNLIPRIFSKEAGLEYIEELEKVLSSLPEYNITIEEKTTCLKDPMCYWNYFDEKCYCHRNPCDTLYCYPDMDKSDEVCICSMLLCQWNGTREGCGILRDDSRGEWCVCNASFSYHLFNFPPVSKRCINSSCGTLGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVW7</accession>
    <name>A0AAV6VVW7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000011">
        <property type="protein sequence ID" value="KAG8200894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVW7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="123" mass="14171" checksum="CD74672148339E45" modified="2024-11-27" version="1">MCYPSQREVSQFVRIPLTCPGNGMLGEAAARLFAVRSRTDCLLMAHRDRQIRKEKLMPSIAFKDERATFKSIPLMSLMYVSVLFQFGLLNASFPYSMKTEVPQFSRHEKGSFFYCRMDQEAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VX23</accession>
    <name>A0AAV6VX23_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VX23"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="132" mass="15243" checksum="F500DD64820AB949" modified="2024-11-27" version="1">MIHCSKPINHHPSPNSIPSFNKSTKPPKRNPILIRPANERCPPCPLEALAITCHKVWSRRWADWEFTISWLKPLATPFPPFIYLLNGWSQEIAPHPPWYIFIVHSNVMHRINDAVARSVYRACPKATCPMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VX62</accession>
    <name>A0AAV6VX62_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000007">
        <property type="protein sequence ID" value="KAG8201214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VX62"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="133" mass="14825" checksum="B994067DD019C12F" modified="2024-11-27" version="1">MSKQASNQKSVGGYKTIKDECVGSLENERNFQENINNPALELLTKPEKRSESSELRARAPSLITSARGEDKSICFVGEFIYSPQIASEFRYGRWSLRGCFHCRAAMAWGEEGLQGVGIVWESTGEKWTLDGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXA1</accession>
    <name>A0AAV6VXA1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_022331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXA1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19724">
        <property type="entry name" value="bHLH_TS_ASCL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015660">
        <property type="entry name" value="MASH1/Ascl1a-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935:SF106">
        <property type="entry name" value="ACHAETE-SCUTE COMPLEX PROTEIN T5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935">
        <property type="entry name" value="ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="257"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8200721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="322" mass="37071" checksum="84CA0C69D9006D85" modified="2024-11-27" version="1">MERSNTLGFDDEYIPSGSWYPQGFDETQIQSFFPENHPPPPYLHKTTHQKTYHNLDSVNLDSSISKNNMVNSQNYYSNRSLNDELFSNSHSSSNFDEGPSHNSYKNNNLENVIFSNCYSCSNFEDDSFSNAHSNTNFEDETLAYSHSHSTSSKSSSDMNLKDVLFSKSHSNSNLMDIPLSNFHSNSNFEDEPFLKSLSGSKLKDVPFSNSNSNSKLKDVPFSNSNSNSNLKDDPFSVRCRIPVPDSMSGYHMWLETSFMCRRNERERQRVRSVNDGFSKLRNHLPRGVQMRRRQSKVDTLRNAITYIKQLQKLVDEKAEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXY2</accession>
    <name>A0AAV6VXY2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_020597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Mu family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000011">
        <property type="protein sequence ID" value="KAG8200961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXY2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000003">
        <property type="entry name" value="Glutathione S-transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003081">
        <property type="entry name" value="GST_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF222">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01267">
        <property type="entry name" value="GSTRNSFRASEM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="86"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8200961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="221" mass="26366" checksum="5DC7F54FCC7927A1" modified="2024-11-27" version="1">MAKPIFGYWDVRGIAEPIRYLLRYKNVDFEDKQYLLSDPDSWFGTKFTYGLDFPNLPYYMDGSVKLTQSTTILRYLAKKYNLEGETEEEKLRVSLLEQQIVDWRTSIIRLVYNENYEKLQPDFVKGVPEQLKRFEAFLGDRKFFAGEHLTYVDLMAFEIIEYYRYMVNKVLDGFPVLREYRERMIELPGLKKYLESPEYRSWPLFAPHAQWGGKGPEPKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZ47</accession>
    <name>A0AAV6VZ47_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000013">
        <property type="protein sequence ID" value="KAG8200831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZ47"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="144" mass="17120" checksum="26DE1763CCCA3091" modified="2024-11-27" version="1">MKEDQRSPKTLTWKPCWRHPSAESRRTMQIKEVYKAVAGWQPPRKKTGRHGRIRERYSGKHGSDRKRSRSRGRKISRNPDRRNCRSVECRRGSRSRDRSIRCDRGSRSPRSDRRGREQDQDETLFEEAPLDHKHNLLAVLETNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W013</accession>
    <name>A0AAV6W013_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_024322</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W013"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16129">
        <property type="entry name" value="Ubl_ATG8_MAP1LC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000149">
        <property type="entry name" value="microtubule-associated proteins 1A/1B light chain 3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8201452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="142" mass="16704" checksum="7E16D1E3775C709C" modified="2024-11-27" version="1">MSQSYETDTFPRQSTLYNMSEVKSFKERRSFSQRKKDVEQIREQHPNKIPVIIERYYGEKLLPLLDRSKFLVPDHITVGELNGIIRRRLQLHPNQAFFLLVNQRSMASVSMTMSDLYAREKDEDGFLYTVFASQEGFGSNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W273</accession>
    <name>A0AAV6W273_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Insulin receptor substrate 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein chico</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_027269</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Bindings to phosphatidylinositol 3-kinase and SHP2.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W273"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005158">
        <property type="term" value="F:insulin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01257">
        <property type="entry name" value="PH_IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01204">
        <property type="entry name" value="PTB_IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039011">
        <property type="entry name" value="IRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10614">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10614:SF13">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00628">
        <property type="entry name" value="INSULINRSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="7" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="IRS-type PTB" evidence="12">
        <location>
            <begin position="141"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="241"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="731"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="874"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="944"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="947"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="968"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8201785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1065" mass="117482" checksum="094429F7472FA1F3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCN7</accession>
    <name>A0AAV6TCN7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_010273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007581">
        <property type="protein sequence ID" value="KAG8155653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCN7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043462277" evidence="2">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8155653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="126" mass="13488" checksum="F2B313D43A7C376C" modified="2024-11-27" version="1">MRELGLLLLLFIGVILFPSAVYYPGAAGERSHFKSTPGPLFGGGLVTMTRVLGLRRHGAPFGVWGKIVGSCAPSGGVLTIALPVPPSRVQLPPTFYHRETDQEEMHPTNFQPRPASPSRPQGGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TET3</accession>
    <name>A0AAV6TET3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_021336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005768">
        <property type="protein sequence ID" value="KAG8161385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TET3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF2">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043473518" description="Protein sleepless" evidence="2">
        <location>
            <begin position="26"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8161385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16504" checksum="E7D141563DB975B5" modified="2024-11-27" version="1">MNSGLVVSAWILAALCVWIPTPGSALKCHVCNSVYNDSCVVIDTNQYLTDCMKINHDTKRNYTICRKESFSVSSTEFQMTTSRTIRTCGYEKHPKFDCFYNSNHDIKETICECTEDGCNTGSNLQFMLHNLVFGILSTYLLSNTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TF17</accession>
    <name>A0AAV6TF17_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of rDNA transcription protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005506">
        <property type="protein sequence ID" value="KAG8170413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TF17"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39019" checksum="8B9695432ED69CF2" modified="2024-11-27" version="1">MIGRADIEGSKSNVAMNAWLPRASYPCGNSSDTSCIKLVKSKGSIGPAFAVRIHTENQDQASFCPFALREVSVLAELALGHLRYHLTDVPPQPNNPPESVLGADRALQGGSALGARSVILTGRFPLNRGPTEAQPGTPQEETRCFYENSVPSPARAISRDTTRYKERLNLPGSSVDVSQFGCVTPHLVPKDLSPCPGLGNINPIPFRSAARHKHEHVLRFRQTSLDFGRDFSIPWTRLDHVQLLFTWNPLQLQSSRFSLEYLLIPQDQHRWRLQAGSRPSPSTHATQRPSYSLRVKPHEEAHAVAARYRPNAGKRPPFSGLFASVGEFLHPQRIPTSRPSSDCLEQPTPFMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFD3</accession>
    <name>A0AAV6TFD3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005644">
        <property type="protein sequence ID" value="KAG8169247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFD3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8169247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="8684" checksum="0A7E7C8188193C9E" modified="2024-11-27" version="1">MLFPFWHGYTQERGCRRFPPPQTTGGKLCCLQSGKGAKNFFKTSEKGEKRVCGKIPALRFSKGRVCGTLASKGVFPNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGF9</accession>
    <name>A0AAV6TGF9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005069">
        <property type="protein sequence ID" value="KAG8170661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGF9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16706" checksum="7F7DA83F3B5D8447" modified="2024-11-27" version="1" fragment="single">LYAAADFYDLDPLKQVCSEILSDGLCATSALGVLSMADLHQDQQLKSAALDFISLNDKDIIGTKDWTKFGKDNGNLALETLRELYCSSGRIFGRTAQPGLVRASPVRSRRLFATQSRRLEASRTLMTVLGSSTSTSSGLFHHHKVQEEKSHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJI1</accession>
    <name>A0AAV6TJI1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003745">
        <property type="protein sequence ID" value="KAG8171631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJI1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="744" mass="81904" checksum="5B662C24D0E32403" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJX4</accession>
    <name>A0AAV6TJX4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003398">
        <property type="protein sequence ID" value="KAG8171914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJX4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="158" mass="18082" checksum="4453848A6E6CAF3D" modified="2024-11-27" version="1">MLTIFQKTLPVLLCNTKLRGSFSDPTIGHNTSATPKNVSERNSRSTERRTECVCGNTEDAITYIQCTGAGFSLRSPQNASNSVQQGLSRGQEKVHQWSKRRSHPQELQHEDARPSRRRSSHLLRKYKSEPVPEAEIEEYYVSFHRVSRSLRVIENARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TK74</accession>
    <name>A0AAV6TK74_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003429">
        <property type="protein sequence ID" value="KAG8171886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TK74"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="403" mass="46093" checksum="B0AB5CE2A5002D0B" modified="2024-11-27" version="1">MSSRSDCIFPRPVDIVAALDSSKDYWIAHLLQVMAYVSHITGDGDRIYHKPLDQNTFIKGKGLEHLKFCLHEVLGQVPFDSRQLDRTWDSIGRRLRRDPSRSLSNSNVCLLFKLHNMFLVKKGFTFGNWLVAEDEQHVIQTSNAAMLCFVLPKNSTIPVQERMRRHLPENYQVFYDRYVLPPHGTYLVPQNTRYVLVAVQKTIFALDVISLEYLFQGATPFDACKRYCTQQAEYNVPPPTPCRSPEPPPELMPPPPPKKRKSTWGSFKIPKKNCQPTLPIPVVPEPTLPTTMQPEIVPLPEKASHQFVPEMDFNSLEMVEEASEKSVADYVNNFFSNISFGDDPFQKSSFPDLDLSFLEQPNNNLILNPAQSKTIFGNPKDFSPVQIFYEEPEQEAPVNYSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKZ2</accession>
    <name>A0AAV6TKZ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_005489</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002853">
        <property type="protein sequence ID" value="KAG8172293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKZ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF10">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 78C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8172293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="53" mass="6476" checksum="6270F9540272F20C" modified="2024-11-27" version="1" fragment="single">MTAIKQGFFRRSIQKQIDYKCLRDKQCLVIRLNRNRCQYCRFRKCLDVGMSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMR7</accession>
    <name>A0AAV6TMR7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_005726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002106">
        <property type="protein sequence ID" value="KAG8173064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMR7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="38"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8173064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="284" mass="31684" checksum="D9062C69682A800A" modified="2024-11-27" version="1" fragment="single">MFSNFKIPQLYNITHKQTFTQISPAARRDSPKVPIDVCSLRSQRGTCNNNTLRHFYHSFTGKCFPFIYSGCDGNGNNFLSAEECMQRCGRSKSTSRIFSSIFTEETDFQGPQVKQGDVCSLLPDRDIVEEIHTDTTTTKMRGNVCHSSMEDVQETQIGSSQNRSVFSGVVTREVLQPKAFRTGCDGNENRFSSEDLCMLACGRNKATTTVSTMTQTVEVEEESINNTDACDLPVARGNCNNNSQRYFFNNLSGQCLQLLIVDAEETLIILSRKKVANNGVGKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNH9</accession>
    <name>A0AAV6TNH9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001690">
        <property type="protein sequence ID" value="KAG8173505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNH9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="118" mass="13710" checksum="D41BCCC9F4B48B1A" modified="2024-11-27" version="1">MMRRRKRRLMAMDIGQKEEESCFSADEESFGYKLNDAEDSSDNIPSSSEEESDILIYAGQKFKKMLGENDTGTPKYFSHVDGRCEISFDNTTSSKEEAWKTFEQQIVSRFFIYPGKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPX1</accession>
    <name>A0AAV6TPX1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_001684</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001537">
        <property type="protein sequence ID" value="KAG8173699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPX1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005228">
        <property type="term" value="F:intracellular sodium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8173699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="85" mass="10076" checksum="3733F3360443E040" modified="2024-11-27" version="1" fragment="single">GNIWHHIFSFNFTLELVNNVPFIATMFWSPLRNLFIPSFLNCWLAKFALEHMFHDLHRAMQRSQSALSHRLMILSATLLCLIFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPX6</accession>
    <name>A0AAV6TPX6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001510">
        <property type="protein sequence ID" value="KAG8173743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPX6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="118" mass="13228" checksum="FD69A0172AC4B56D" modified="2024-11-27" version="1">MFGKLAEYDQAVETWSEYVERVNCFFDANDVKDEKKASIFLTIVGPAVYKLLRSLVAPATVKEKTFTQIIDVLNTHYSPAPSGDCGAVPIQFPGEASRRNRRYVRLGASSAVRVLQLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQ48</accession>
    <name>A0AAV6TQ48_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001375">
        <property type="protein sequence ID" value="KAG8173989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQ48"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="10084" checksum="C516D97015C8D814" modified="2024-11-27" version="1">MFSYLHLHNPVAYALLESSFRMVSSNALSWFSLLSLPSFVAAKEALIEFRSHSSSICLIAELSWLHSKAFYHIAFDVSFVESGYAIKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TY27</accession>
    <name>A0AAV6TY27_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000849">
        <property type="protein sequence ID" value="KAG8176753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TY27"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8586" checksum="12BDD24BAD5C7AC1" modified="2024-11-27" version="1">MKEKALEPGPMRHASHRHIPVEGHVESGFSINKDMLVENLHEKSLIALRTVYDGIKSNCGIENVQITEELVNHRGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U069</accession>
    <name>A0AAV6U069_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_020446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000780">
        <property type="protein sequence ID" value="KAG8177419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U069"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043865656" evidence="2">
        <location>
            <begin position="18"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8177419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="153" mass="15261" checksum="42AA699671DBA180" modified="2024-11-27" version="1">MNAIVLAVFLVIGTAIAAPEPDPQFFGGGNPFAEFPFGGGGGPFGFVNDIFSNIAAGKGGLPAPISVPSVQDGYRGDDVQDNNFPFGGFSFDSFFKDFFGPPPSKSSADNSADDGSYSAPPPPVAQASAFAGPAPPSSTPAPITPAATTTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0Y3</accession>
    <name>A0AAV6U0Y3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000759">
        <property type="protein sequence ID" value="KAG8177704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0Y3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="544" mass="60819" checksum="A84F25C8B8EB3180" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U145</accession>
    <name>A0AAV6U145_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_014274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000799">
        <property type="protein sequence ID" value="KAG8177230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U145"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF60">
        <property type="entry name" value="MISFIRE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8177230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="453" mass="51005" checksum="3E0D8E649996E02D" modified="2024-11-27" version="1">MASATTSDEDSSTEMPLLQTRQCARVCVRIYRADGLPALDSGILACVKKQCSVDPCRLLDLYVRVSFAGIEGCTSKCRRSPSPEWNEQLVFSHPFPLPHDGPLVLQVRDHDFVAGGVLGTSLVPIEQISDPGDEGFLPTFGPCFVYLHDKDDSDPLYKGRLLIAIHTEVTSECDFTKPFVANESIPPLPQGSYGSDQEFLLFACAQEASMIPRRVGERGDVRFTLQLGEIGRDPKEMGEGSDCCTPSFQAVSTNREYMHVPFGENLPCMWLKGKWPDNRKRMYASNVLHKMVKKLKECLRTIEKPGNAKVPVDMENNTKCLTDLEEASKKYLKVLKECSEPYAGMTQLDNERAKIFECDIASIMRVAAVAKTAPNKTMLESALQKLRKLKSKLKTMARNLYDISALCPTRFTNTSLVRDFEAHQMVPFLCNRWILDADYKRLTKPCYFYDRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1C1</accession>
    <name>A0AAV6U1C1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000778">
        <property type="protein sequence ID" value="KAG8177451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1C1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="124" mass="14211" checksum="442B54C8BC73C0AE" modified="2024-11-27" version="1">MSARKEKAMILSSDEEDFVPLKRKKKSFGEPSIKKKKALKVDVNLSQNEPAPSSSKVLEPYSIYIGNNVVCEIKHFKNAHYLGLYKSVEGEIKNRFNINLKQILTVKRAIETMIEYCNANDFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U258</accession>
    <name>A0AAV6U258_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000713">
        <property type="protein sequence ID" value="KAG8178184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U258"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="26766" checksum="D871A078FB73F6DA" modified="2024-11-27" version="1">MPSDGDDPEKESIDSVLGDICAGGSSQYSFNKLATSASQFMINIKGINTFIKSVDIVEAYLHRLSLRSDRPSHGTSLPCCLALLYILLAVKEDGARGVEVQGTTIKFLAYSDDILIAAPSTGDIQAHLNAISDSDEKAGLRFKPRKCASLGIRNASGNGGILPDRTDGNIVHVAIRKCGAGVQSLSDTVDIDHLTYAMKMLASKDQLVRESAMSSLYEAVRKEAGVDPTDDNIFSFVLGSFVGQCDFGAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3W3</accession>
    <name>A0AAV6U3W3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000705">
        <property type="protein sequence ID" value="KAG8178284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3W3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12360" checksum="410C20732710BC38" modified="2024-11-27" version="1">MNASVYEGLLPRHFAPKRGQWGTFPVGTIFRETIHFNETHKTSLEFFKNSRVPLGVKKEVVEEYIYRASSGMTEELGPFVTWGRFALIAVGILNNGSELGLVPQGRMRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4L4</accession>
    <name>A0AAV6U4L4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000643">
        <property type="protein sequence ID" value="KAG8179212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4L4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="28678" checksum="FB20267BBB9C6BDC" modified="2024-11-27" version="1">MVTTALEGSSVETNFSQNLEGLIQYHFEISDSEPTEETTSRGAIFDPITKDELEYSVNSQGLDKAPGPDGMGPSDVEPTNLKKDIYPGKSLANLCLYPSGLPSNIKADICAFTDGSKSDAGVGSGYVLRVALAALYPKSPIILKIKTLCTELADKTINLGWVKAHVGLMGNEIADSIAGAAAEFGVSSPAVLSLLGPLAAASLGGGWSFPALLGFGGLNLRGGRVFGLACPYLHRSPAIVDIGPISDIYYDPTILLCGRVFVESRKSIFVFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4N2</accession>
    <name>A0AAV6U4N2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_025027</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000642">
        <property type="protein sequence ID" value="KAG8179250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4N2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8179250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="292" mass="32979" checksum="567E01A723CB37D0" modified="2024-11-27" version="1">MPPPIRRTAMPMVIQEPLRTTSLLTSNSATITSNSRPSMVNAGASTSAVIYSPIFGPHQPTSLPNVCDTCRKTFSNKSNLTRHMKNHAEGSIGFDCKVCDKFFTREDNLTRHMKSHDSEEHVCPKCPKSFIRKDMLAKHMATHNRPVKRPQHPTSASGTKRRRVEKVSDVFATRTTGYDVTMPNRHILYLDANNLYGWAMSQPLPVSSYEWVAGEEISEETIKNCADDADKGYILEVDLDYPKTLHDAHNAYPLAPEQLCLTYDDKRWLCEDSIRSYAYGHYRIAELLGDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U596</accession>
    <name>A0AAV6U596_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_005462</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000649">
        <property type="protein sequence ID" value="KAG8179106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U596"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="15">
        <location>
            <begin position="87"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8179106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="355" mass="41507" checksum="D6D476818139F163" modified="2024-11-27" version="1">MTPVPQLVESNEPEKENEKQHFRKELSIRNEDINKNSDFSLVPEEKEDVETNIPEYKREIVYFNILLFILLHGTCFYGLYLGWTSASWKTNIFAILYGYVGGIGITAGAHRLWSHRAYKAKWPLRVFLCILASISSQGDLYRWCRDHRVHHKFAGTDADPHNIKRGFFFAHMGWVLCKKHPLVKAKGDVMDLEDLKQDPIVMFHKNYYIPQSLFFGFFIPVMIPWYMWGESLWNAFFIADMTRYCISLNIAWLVNSAAHMYGDHPYDTRVEATENSFVSFFAQGEGWHNYHHVYPWDYSTSELGYKLNTAKRFIDLMAKLGLAYDLKTVKQELVDKRKIASGDGTRQEQLLKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U679</accession>
    <name>A0AAV6U679_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BCCIP homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_026303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000627">
        <property type="protein sequence ID" value="KAG8179403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U679"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8179403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="284" mass="31961" checksum="51ABC3E908E5A5F4" modified="2024-11-27" version="1">MAGPRKQRRLEQNDSSSDSDESVNQEDEEMETIQVDFDVKMPEPSDFHGIKNLLHQLFLKAHINTSELTDLLISQRKITGVVKQADGGDEEMDADDDPEDLDASFGVFSVVNITEHSTKECVNEIHTYLLSHGKKGCDDEKFQMLRRILEDKKKHVGLIISERMVNIPAQIAVPMYSSLSYDLSKATAKGEAFDFEYFILISKIVVFKDGSKDENVLYTNAEEELIAEVATLSYDFSVSSELDSGLAGNWTDDDIEGKRKRRVLLFPASQLEHINSKMSSELAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8X0</accession>
    <name>A0AAV6U8X0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_023671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000588">
        <property type="protein sequence ID" value="KAG8180054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8X0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF72">
        <property type="entry name" value="HEPARAN SULFATE 3-O SULFOTRANSFERASE-B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="6">
        <location>
            <begin position="102"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="3">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="109"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="316"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8180054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="353" mass="41062" checksum="373C3364156168C0" modified="2024-11-27" version="1">MTVHVQSVMQRFMWRYLAIVLTLCLVVSVAYLDVQARYRTMPDIEEEWNASMRRRNLLKRSEWWRNDDQWSSVEESVSDLFDSEERSDTNPKKGTKRRLPGAIIIGVKKGGTRALLEMLRLHPDVVAPGPEIHFFDRHYDKGLHWYRNQMPLSRSGQLTMEKTPGYLVTPGAPWRVSSMSKDVRLLLVVRDPVTRALSDYAQAASKRTQDTRSFEDMAFRNASTGLVDADWSAIRLGQYAKHLERWLRYFPLSQIFVVSGEKLVEDPVQELQAVQKFLGLRPLIGEQHFFFNQSKGFPCLRKAPQSKVPRCLGKTKGRSHPIVAPPALQRLRDFFRPFNQKFYRMVDRNFGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9V4</accession>
    <name>A0AAV6U9V4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000541">
        <property type="protein sequence ID" value="KAG8180902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9V4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20830" checksum="D8F53F27FA33D587" modified="2024-11-27" version="1">MEIQTGLEPLKIRKQLVILHEKCKRSGLQRWQHYTTANARLKTHRTFFSCADQLNDLYNLASTQIYPFTTSLSPPTCRTPEYSLTIGISEKKCDTISEALRAFSLEVMATKYPREEGIHIHTDGSAGDGNTGAGAYCEGFFEKSCAVGFHASNFDADIYTIKIAISNLLRLETNLRMTALTLKLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAT4</accession>
    <name>A0AAV6UAT4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysophospholipid acyltransferase 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_003150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000535">
        <property type="protein sequence ID" value="KAG8181101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAT4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071617">
        <property type="term" value="F:lysophospholipid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF16">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8181101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="455" mass="52720" checksum="E570F68B0ACE1C2D" modified="2024-11-27" version="1">MMLDDIVYISLLCSSVALGPIIRTVPNVVHRQWFSTIAGFVIVLIVSGTHAFHSIFVTLVNALIIQFVKSKAPVASAIFSFTYLAFFRSTHYFGLPIVPPHTNAIQMILTLKMVGLAFEVQGNHPENKSKELKNANIIKKYQTINPSFVDVFHYAFCIAGVLIGPYYKYRTYWDMFHMPFSMAVNANKFLKQRIQIVPVYVGLYLLGNFLYPLDFASSPEILEKSFWYRVFYMTPSFFNFRMRIYAGFILGECVCIAMGLGAYPKLCNPQPGAGPTNFSALEEINKHSLHSIEYSYETVKNIFEYGSEFWPTIREGIRAWNRTVQFWLATFVYKQLSLSKPFKICITMLVSSFWHGVHPGYYLCLCSAPLFLFVESEVEKAFKRNAPHVQQVLFDWIWWFIKMQSFSYMGMAFLLLDIRNCLYFWKSIYFSGHIFIVLLYFLAKHVNKTTKLKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBD4</accession>
    <name>A0AAV6UBD4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000539">
        <property type="protein sequence ID" value="KAG8181033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBD4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="226" mass="25956" checksum="7B8A6C804CFD2C06" modified="2024-11-27" version="1">MYASISTGKRSQKSQGLRKIGCKCPASIKVHITENEMVSVTAYNYHYGHKNELAHLPIPKSDKAALASQLSQGIEHQRILKNIYEDEISEVERKHLCTKRDLLNIAKSYGATICKHIHLVVSYQKKEETEVYDEIRQNQNSNQLDIQDVSDDTLSEHCFETRKVTEQLVPVEDLFERDLILNSINPSGRENLEALKKSLLEKHMQLLEKIMACDNRDVTCCKKSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDA9</accession>
    <name>A0AAV6UDA9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPPP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000476">
        <property type="protein sequence ID" value="KAG8182194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDA9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05517">
        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="14438" checksum="8DEB2C81B2DFCF31" modified="2024-11-27" version="1">MSDPVPIVPKTIGEYFRVFAAMDDPESDNGHRISFKNVRRWFQRAEIMGQPEQDGVLFQFSDLRYAFCRVAKKRERIDCDQFCQMLEIIAREQRIDTQMIVQRLKVSEMMASSMSRLFEGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDU4</accession>
    <name>A0AAV6UDU4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000464">
        <property type="protein sequence ID" value="KAG8182387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDU4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="96" mass="10619" checksum="A2BB979695B633D4" modified="2024-11-27" version="1">MWDRERRSPVLCRDVGRERRSLYSAGNVDEKGGALYSAGNVDRKASLYSAGVGPRKAEHCTLPGSVEPRTTEPCTLPGSFEPRTTESVLCRVFWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF49</accession>
    <name>A0AAV6UF49_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_019986</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000432">
        <property type="protein sequence ID" value="KAG8183102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF49"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF465">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8183102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="340" mass="39098" checksum="FBD088A66BBC947C" modified="2024-11-27" version="1">MRFPELLWSLVNECKSGAIAWSKDGDSVLFDYVKFKEEYMKDITNFKTTNIASFVRQLNLYGFRKYQKPNMYGIKLHEFFHPLFIRGRQDLMNKMKRKSAYSSKKKFFSESSIMQKDYVDKDHVYKKDKKPRRTKPETSSSAENTLDSFPTPVRHIQPTSSMEQMQKFMFNNPLAGSNIANKNMPGFLLPQSWMNPAFFNPGNWNRNVLGGIENLNRNFPRGFGNWNINVPEGTGNWNRNVPGSSEMWNNVPGSTGNGNDPEGTENDENRLYSNLMRGYPVLKRGEGNAHYLIMPGYGPYGGMYPNPDFYMNTMPISGMPIKKDSNEASDKASEEECIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF59</accession>
    <name>A0AAV6UF59_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_010755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000464">
        <property type="protein sequence ID" value="KAG8182394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF59"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043372453" evidence="2">
        <location>
            <begin position="25"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8182394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="199" mass="18827" checksum="46A5F9D814D4369B" modified="2024-11-27" version="1">MGKLMFVALYMALFCMLMLPNVESQNEEYDQEDEGDQPPPPPPPRGGGGGRGKGPNGRGPPPGRGFGGGQGGRGRGGGEQGGDFEGGNQGGGQGGRQGGFGEQGGQGGRQGGFGGQGGQGGRQGGFGGQGGQGGRQGGGFGGQGGQGGRQGGVFGEQGGQGGRQGGFGGQGGQGGRQGGFGGQGGQGGRQGGAFAGQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFV6</accession>
    <name>A0AAV6UFV6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_007300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000459">
        <property type="protein sequence ID" value="KAG8182563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFV6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000148">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000245">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000208">
        <property type="entry name" value="zinc finger protein Gfi-1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000432">
        <property type="entry name" value="zinc finger protein Gfi-1b isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF419">
        <property type="entry name" value="FI21258P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8182563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="394" mass="42966" checksum="87DFB983E0231844" modified="2024-11-27" version="1">MTEAIGPSSVVGAESGKGPAVVNFGEMGSAFRVVTPKRPREGVPSVGTVPRLSSAAPFPLLDPLPTYYSGLWCGLKDPPTLPLFPLFPHYLHPSTYGISVDAFPPTATSAESSTATAGRLSSDVSSSWEDAKSPRSPLSIGDIKSFGLSPWPTDLRVRPVPACHPFPAKNPDSNGPDLFRPAAFTGLSCFGLSLYSFSSSKETPTSASPDALTLKSTSGGDVFSCVKCDKMFSTPHGLEVHARRSHSGRRPFACELCNKTFGHEVSLTQHRAVHTAERTFECKQCGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTYIHTGEKPHKCAVCGKAFSQSSNLITHSRKHTGFKPFACDICGRAFQRKVDLRRHKETQHSEIHHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UG33</accession>
    <name>A0AAV6UG33_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_029497</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000430">
        <property type="protein sequence ID" value="KAG8183139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UG33"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004995">
        <property type="term" value="F:tachykinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15390">
        <property type="entry name" value="7tmA_TACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001681">
        <property type="entry name" value="Neurokn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="121"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8183139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="439" mass="49982" checksum="4D1370FCDD78EEA1" modified="2024-11-27" version="1">MGNAQKKEIDLLELYMDSQEQNFSYNSSLCDDIFTNINGNSSNINGNFNSIHDSISNIYANFSSEESMDISQQLNTSDLYSRCYNSTIPSNIFNQPYILPWYQQLLWTLLFAVMIMVAILGNVIVMWIIVAHRRMRTVTNLFLLNLAIADFLLASGNATFNFIFMLNSHWPFGETFCVVSNFVANLTVSTSVFTILALSLDRYVAVAHPLRPRMTKTVAYSIILSVWTLSSLLSLPSLLYATTITYKYGDETQRTLCLLVWPDGLGTGLGTSDLDHIYNIVFLVVTYVIPMICMAFTYTWIGCILCGSKVIGESSGPQNNVIKSKQRVVHMLVAIMLLFAICWLPYHIYFLYTYYNSDVIHADFIQHVYLAIYWLAMSNSCYNPIVYYVMNSRFRGYFQDVMCLNRLSQKQSTTKTSKSQQIQVKTSIVTSNKSSTSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGI8</accession>
    <name>A0AAV6UGI8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000423">
        <property type="protein sequence ID" value="KAG8183302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGI8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="12216" checksum="50D9B61668486616" modified="2024-11-27" version="1">MGFVGQHVSYICPMQKRPYFGRIFRLRQYRTFSRLLAVCIHLILRPANSQRTVMGTYPPPPPSTSIATAVANGHFVFPPSLLYFPNSLSRELQWKRWQRFECGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGP7</accession>
    <name>A0AAV6UGP7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thyrotropin-releasing hormone receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thyroliberin receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_023974</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000421">
        <property type="protein sequence ID" value="KAG8183325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGP7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004997">
        <property type="term" value="F:thyrotropin-releasing hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002120">
        <property type="entry name" value="TRH_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46061">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46061:SF3">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01846">
        <property type="entry name" value="TRHRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8183325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="96" mass="11264" checksum="E7B412E6A28F2CFE" modified="2024-11-27" version="1">MLIIVVALFAILWFPYRFLVVYNSFAHQRYMELWFLMFCKTMIFINSAINPILYNAMSIKFRKAFKRLLSCGQKARPNIPTRYTTVTTAVVVDDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHC1</accession>
    <name>A0AAV6UHC1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000428">
        <property type="protein sequence ID" value="KAG8183183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHC1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7863" checksum="039A7F1564A6AF1D" modified="2024-11-27" version="1">MRWSAFPTLRHTPFLWPKVDRKSFFLMGSPRGQRVPLSWSVVYGFLPMVTTGCTRWLRIYLSLAGGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHG4</accession>
    <name>A0AAV6UHG4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000407">
        <property type="protein sequence ID" value="KAG8183762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHG4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="144" mass="15790" checksum="16BD4E6C4726DE96" modified="2024-11-27" version="1">MRSSPFFVPLSPSSKAHKAVLAPRYGHNDFGPTMTLPRVTLTTPANAPSVDHNLVLWSSLSRGDKLAATLYVKPVSAKSVRVSDSKPPVRPRQVFSQIKSFHLKAAVSVNAVEPEKICFVRSLMELLEEFVGLSLRMAIFGCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHI3</accession>
    <name>A0AAV6UHI3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000402">
        <property type="protein sequence ID" value="KAG8183832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHI3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="15206" checksum="C4066E2DE6C965EB" modified="2024-11-27" version="1">MIGFRWKNTVDKRQFLMEEPNIVQWRYRYLRFMKKYRDDNRNIIYLDETWINNNLSFGKCTQLEKIDGFKKHTAGQRLIVVHAGNGNGFVGGGRQFRVQVWHRIVRLSWSDELRQLFQVGRRKTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIC7</accession>
    <name>A0AAV6UIC7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_023189</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="JAFNEN010000418">
        <property type="protein sequence ID" value="KAG8183433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIC7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8183433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="376" mass="42252" checksum="84155F759D7F5B65" modified="2024-11-27" version="1">MADEIISERKCETVGCEKLAKLRCPTCIKYDISGSFFCSQECFKGSWNDHKQVHKTAKTVVTQSFNPWPGYQFSGKLRPFPVTPKRDVPAHIMRPDYADHPKGASACEEEMGSSSSIKILDKEEIKGVSLASKLAREVLDTVAKAIAVGVTTDELDRVVHEACIARNCYPSPLNYYRFPKSCCTSVNEVICHGIPDLRPLEDGDLLNIDITVYHKGFHGDLNETFFVGNVDEAGKKLVRITYEALMKAIEIVKPGEKYREIGNVIQKHVQAHGFSVVRSYCGHGIHRLFHTTPSVPHYAKNKAIGVMKPGHCFTIEPMISEGAWNDETWPDKWTAVTRDGKRSAQFEQTLLVTETGVEILTRRRNKNGQPYFMDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UII4</accession>
    <name>A0AAV6UII4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ligatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_025124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF2D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000413">
        <property type="protein sequence ID" value="KAG8183564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UII4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11610">
        <property type="entry name" value="eIF2D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21156">
        <property type="entry name" value="PUA_eIF2d-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.20:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048247">
        <property type="entry name" value="eIF2D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
        <property type="entry name" value="SWIB_eIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26291">
        <property type="entry name" value="SWIB_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="4">
        <location>
            <begin position="389"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="494"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8183564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="65286" checksum="34C2740032F20EE8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJ13</accession>
    <name>A0AAV6UJ13_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein transport protein Sec61 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_029334</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000407">
        <property type="protein sequence ID" value="KAG8183753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJ13"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8183753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10662" checksum="76F78CA220F814F0" modified="2024-11-27" version="1">MHEFLELLLTLLLQFFYREVKEPLMSFFLKCMQFWRRCSKPDSREFSKIANATLIGAIMMGSMGFFVKLIFIPVNHILMASPAENAKYGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJQ5</accession>
    <name>A0AAV6UJQ5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000375">
        <property type="protein sequence ID" value="KAG8184360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJQ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="177" mass="19762" checksum="CC4F383FA0040C12" modified="2024-11-27" version="1">MASENSLRITPLYKKHNTNVAQDICVPLLGIINTLQGTIDPSTSSIEKDIYLIARDMAKFMKTYYKTQLSYGTQNVLAGEFIVPLVNSLLSVKGQPLLSPRTTDSRSPSPGGGFKRSFSVLDTDLRRAKLDLAEFHKQIRSLQENLKTASILQDQLKEANNKIKVLEEDIKTHIATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJR0</accession>
    <name>A0AAV6UJR0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_006868</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. Maf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000396">
        <property type="protein sequence ID" value="KAG8183943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJR0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14718">
        <property type="entry name" value="bZIP_Maf_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000011">
        <property type="entry name" value="Transcription factor MafG, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024874">
        <property type="entry name" value="Transcription_factor_Maf_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129:SF44">
        <property type="entry name" value="TRAFFIC JAM, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="225"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8183943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="320" mass="35428" checksum="2D39A8E22A462169" modified="2024-11-27" version="1">MDSTTDQDYVQEFDLDHLEEVVKQEMHRAKYNSSMQQQHSMMEQHHGYGMMAACHQPRKPVAVAAATPPDTPPCHMPPSPPFPGTTPGQPLIDDGMLWLTQNLRYNGPSNGGPPPNNQDGPLDLRPPQCAADMEAWLIGPPSRRGDYPDVVQGVPPTPQHLMHQQPPSSSGSSSSGSSCGSLPCHPRQPAAGAADPLLNDDQLISLTVRELNKRLHGYPREEVVRMKQKRRTLKNRGYAQNCRTKRLAQRHELESRNRLLQGELGRLRGELERACQERDFYRQQLHAIRGNATSAPRSMSSVSSSGGGPPSNPSSPEFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKT8</accession>
    <name>A0AAV6UKT8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000355">
        <property type="protein sequence ID" value="KAG8184894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKT8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8663" checksum="39E3D252868D9A22" modified="2024-11-27" version="1">MRAVLRGQSWGGMASRNISLPFRIIEFNHFGGTVTLLDFEIALHCVDFTSVGLLEETLGFKLVSELFCELVMRARSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULW2</accession>
    <name>A0AAV6ULW2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease GEN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_006335</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000345">
        <property type="protein sequence ID" value="KAG8185132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULW2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09869">
        <property type="entry name" value="PIN_GEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041012">
        <property type="entry name" value="GEN_chromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF70">
        <property type="entry name" value="FLAP ENDONUCLEASE GEN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18704">
        <property type="entry name" value="Chromo_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="11">
        <location>
            <begin position="118"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="463"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8185132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="56226" checksum="4CA21B63789E4AEE" modified="2024-11-27" version="1">MGVTGLWKILDDLDLGETKDLSSLSGKRIAVDTSGWVVQANTTKGLNESRAPYLRNVFFRANQLLKNGILPIFVLEGKVPPLKEAAFKDRNHQGTSQSSTIGRAKFDRILNECKTLLQSLGVPCIKSSGEAEALCSFLYINKIVDAVMTEDSDAFLYGADIVLRGFTANEQESHFKEYSLKSLKNTLDLDQEKLIALALLLGCDYDEDGVPGIGKETAIKFLSELNGYDPLKRFLEWKQKGESEIYPGYDSSIKKQGVHCKQCNHLGCLSEHSTTGCTMCKSEISCFPSDGKNLCSCAFHKTQEIRLHHKAELKIYHAAREKPNFPNLEIVKEFKNYDDKTPDNSELEWDCPNLEKFQMETLKFLRWSSEDSHKKVFSLITLWQQLQLSQNNISSDRLLYKPVKIVKKRTKNGKGCFEVQWSKTGEDVSDASLTNLCTIEIEDKFKVAYPELSEEFYNLNTAKNETKAKAKSPKNANKNKKMTEFYSATKHAKRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMN6</accession>
    <name>A0AAV6UMN6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000360">
        <property type="protein sequence ID" value="KAG8184805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMN6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="208" mass="23835" checksum="D076A76163F9A714" modified="2024-11-27" version="1">MKENFGINAEDVENGGEFVAEVNIPNLKMQHEMPENNEHDKMKANFGINAEDFENTGEIVVEGIIPNLEIQHVELEGNKQMKANLGKNIADFEVRDGVCPEAISVPQVQKAKRIADVLRNATGKFFLLQVNRYRIHRAKMAFTSTLADADNEELESSTDLNVAYVNTSNLRRRKREPEDEPSATINKRKKWKSFKTRFSHIKKFFKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UN55</accession>
    <name>A0AAV6UN55_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_004414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000322">
        <property type="protein sequence ID" value="KAG8185872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UN55"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042775">
        <property type="term" value="P:mitochondrial ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008535">
        <property type="term" value="P:respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042289">
        <property type="entry name" value="COA6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8185872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="9594" checksum="45FF97B5746B0717" modified="2024-11-27" version="1">MSFPDKDKRKKCWATRDVYWECLDKNIDNPENCLNERKCFENDCPNLWVHHFDRKREYIKFKEKLQSEDPVEAIKIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNK3</accession>
    <name>A0AAV6UNK3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Hormone receptor 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_025873</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000343">
        <property type="protein sequence ID" value="KAG8185201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNK3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07168">
        <property type="entry name" value="NR_DBD_DHR4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="245"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="426"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="117"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="342"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8185201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="73398" checksum="007AAF4290BC04D7" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UP27</accession>
    <name>A0AAV6UP27_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000309">
        <property type="protein sequence ID" value="KAG8186202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UP27"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="175" mass="20121" checksum="A078B76445CCC5A6" modified="2024-11-27" version="1">MAFRFFQWIRREFILRPLVTSKSSFATVENEPTESLLIGKEPKLTKKEKRLKMFLQAVGVFLPSVYLGHVLSNHDIFGPSVKEKKRKRIAEEEREKALEKEEEKEEMQEKKEEDGQSKNEKKASGEEEKSKDSKDNKEKAEQGDGDSKNKEKEDGNDKGNKKEAKDSNAGENDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UP82</accession>
    <name>A0AAV6UP82_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_018642</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pleiotrophin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000336">
        <property type="protein sequence ID" value="KAG8185423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UP82"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048332">
        <property type="term" value="P:mesoderm morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.90.10:FF:000001">
        <property type="entry name" value="Pleiotrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.90.10">
        <property type="entry name" value="Heparin-binding Growth Factor, Midkine, Chain A- C-terminal Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020090">
        <property type="entry name" value="PTN/MK_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038130">
        <property type="entry name" value="PTN/MK_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020091">
        <property type="entry name" value="PTN/MK_diS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21050">
        <property type="entry name" value="MIDKINE AND PLEIOTROPHIN 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21050:SF1">
        <property type="entry name" value="MIDKINE AND PLEIOTROPHIN 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01091">
        <property type="entry name" value="PTN_MK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57288">
        <property type="entry name" value="Midkine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="MBD" evidence="9">
        <location>
            <begin position="239"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="515"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8185423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="61547" checksum="D742380C829B11E1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQA7</accession>
    <name>A0AAV6UQA7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcriptional coactivator p15 (PC4) C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000334">
        <property type="protein sequence ID" value="KAG8185476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQA7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="1">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="221" mass="25930" checksum="0AB07FBDBCE09E48" modified="2024-11-27" version="1">MSMPPNKKFKMNAPVADPSPVDSRNAFKLDSIPDHHYHLGNHVFVVVSEFFDSVKIHIRKYIQEMDYMKPTKDGTTLSPLTWQEPPDSMCIKSFHYYANRRRVSLLNDELFIVAARNQEKEEIVLQKLFVKKDLSRQFMPNVISIDELQFNTLESYEKEITKSVFTKMFQVLFRRKAFTVFSKIKCQQPLPTTDCSVGKKFLTSTIEDLLFAKLKRLYLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQB5</accession>
    <name>A0AAV6UQB5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 16">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_028893</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RAD18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000321">
        <property type="protein sequence ID" value="KAG8185893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQB5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16529">
        <property type="entry name" value="RING-HC_RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="20">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8185893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="439" mass="50519" checksum="5D3075A41340CE5E" modified="2024-11-27" version="1">MASKYDSISNFQSLKDATELLQSEMNNKYLKPLDEALRCRICFEYFNNCMITKCSHNYCSICIRRYMTVKAQCPICFQDASEPELRNNRLIDEVLRTYMKIKELLTETVLSETKSQPEYLKPVKLISVEIENEPSKSDLCPDDAKEDDCKDNEVACPVCYKLVLQDRINIHLDSCLKRTEGYSERKTLPKLVYHLLSDKEIRKKLKEHGLSTSGDRQTLIRRHKNFLTLYNANCDSLTPKPVSELILELEKQELEERLNSFTKPIQVHKKSNPSEIEAEQRSYAKQHQPQFSELIQDIQQRQIKEAKIKLEVQDDDYTDLDFTKHSSKKETESAGTFLSFSDAKASKSYKSKGKDKTFDVESDSDVDCDKTIKQEIKSIVITDAFSISKSDPEIQDVPTIDPALSLDDHETGKITQLSLLRKRKKGKVSVGRPCSPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQN9</accession>
    <name>A0AAV6UQN9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_009228</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000300">
        <property type="protein sequence ID" value="KAG8186469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQN9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8186469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="55437" checksum="C38040BBC13CFE50" modified="2024-11-27" version="1">MRWRGKKLRVFQDLGIPGPQPHFMFGNILEYNKKGPRQCYEEWIAKYGKIVGFYHGLRPVLLVADPELLKKIFIKDFNLFSERPEGVPLRVHTFLDHIIPASKIMDNLLINLKGERWKEVRSILSPTFSANKLKMMIPAVNEVTEIALKILEKKSATGNSVDIYEILQRLTLDLICAQAFAMNTDSLNNPSDPLLRSAKIIFDLPLASNVIFFGRCFPELSFFAMAYNFLSMFIRNEGNIPPLKITKVVEVLIKQRRKYSSMRKPDLLQLLIDASAPNEDQVEHANNKVVGEKLKLTDLEIQSNALVVFLAGYETTSSALAYFFHFLAKYPDLQKKIQAEIDQLMEKEGELNYYNVRNFQLIDRFLLETMRFHPPAVNFIWRVAATDVDYGDVFIPKGMEINVAVDYIHHSAEFFENPEEFDPDRFLNGNSTKNQSVNYWAFGVGPRMCIGTRLVHLTAKIVLAKILHKFTVEAVSSHDEVCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTP9</accession>
    <name>A0AAV6UTP9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_000398</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000284">
        <property type="protein sequence ID" value="KAG8186926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTP9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF42">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR SEB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8186926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="317" mass="36737" checksum="BF8CB133AEBA1543" modified="2024-11-27" version="1">MCTYMWMFCEGFYLHKLIAAAFAEQKSLYMFYFIGWVFPIFPVGTVALLRWYFANEQCWAVPVKPYEWVANSLNLLSLFLNLMFLIDIIRVLWTKLKATHANEPSQFRKAVRATLVLVPLFGLHFFLVMYRPQSGDCLMLEGYSYFAYAMDGLQGLLVSLIFCYLNGEVQVLVMRSFQRIRLQRKLTASSDWRRSTRSEELSNRKIRLVNVCQYVFRVIELIRRSIDRFRLRYSLDVQPTSMTMMSDVSMSRSRPSADGNSDFTTSGRWRRSNAGQNETLPNNGNMAVTVELNALVSTIPEKESEVDCVETSLINHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUQ5</accession>
    <name>A0AAV6UUQ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CXXC motif containing zinc binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_009920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000251">
        <property type="protein sequence ID" value="KAG8188046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUQ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8188046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18385" checksum="FF0107532DA529E3" modified="2024-11-27" version="1">MGKIGLQIKVVLEGITDLEAYGEDFRWYMKLKCMNCGEEPEKWQYVDLTEKLPLKGGRGEANFVSKCKLCSRENSVEILPESRKMYTAEDSETFKTIVVFDCRGVEPIDFSPRIGFRAKGESSGTKFDEINLEEKEWVDYDEKANLSVSICEMEHKFVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUS1</accession>
    <name>A0AAV6UUS1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000246">
        <property type="protein sequence ID" value="KAG8188212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUS1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="135" mass="15282" checksum="3BE6AA29A2A47F15" modified="2024-11-27" version="1">MTPYRRLSDLLRCRRRISKNHDVILPVSICPWVRSIHGRGKKSRGVVVAPPLGGAIITSLRPMGGRRGDRCARHLVIGELLRPRGRIFCDAGRVHRNFQRGCPGPKIRLGGEVERSSHEADDRPRHWEPWSRDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXW0</accession>
    <name>A0AAV6UXW0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000241">
        <property type="protein sequence ID" value="KAG8188345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXW0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="360" mass="38099" checksum="08F5CEF6BE2FCA62" modified="2024-11-27" version="1">MVPSRPYQDPSTKATLQISLIKMQQVKTMGTSILLPIIFAIFAINSVASQEKVLFGQPSSISAEARQSPASDAAKDTVAKDGGSGRKARVFTFPGSSNQQQQDPRTHQPSYVISSPYEAGSPYETTEDRFAAAAASQDENNRLLSFLPTFGDNGMQVGLDFKLPFFQIPYAKMFSGGGLGGLFTNRYGSSLPAASATSSLGHSALGSSLLGSSSSSLATMAAMAATAAMLYPKVSNMFSLDGKGVFRDGGSTDDFLHNMNSVLGQFNIDGESCLKVALCSLGNAKQRQHTRGRNAQGTSTPADVVDNILNLPQVKKFMSKGSLTQARDFGGSGGDCDYFNDNSKCPVSAQTFQNMFSSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZJ8</accession>
    <name>A0AAV6UZJ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Probable cGMP 3',5'-cyclic phosphodiesterase subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_014968</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with Pde6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the PDE6D/unc-119 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000227">
        <property type="protein sequence ID" value="KAG8188915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZJ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050953">
        <property type="term" value="P:sensory perception of light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.40:FF:000002">
        <property type="entry name" value="Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.40">
        <property type="entry name" value="GMP phosphodiesterase, delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008015">
        <property type="entry name" value="PDED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037036">
        <property type="entry name" value="PDED_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017287">
        <property type="entry name" value="Rhodop-sen_GMP-Pdiesterase_dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12976">
        <property type="entry name" value="RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE DELTA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12976:SF0">
        <property type="entry name" value="RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05351">
        <property type="entry name" value="GMP_PDE_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037825">
        <property type="entry name" value="GMP-Pdiesterase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0140">cGMP</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMP phosphodiesterase delta subunit" evidence="7">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8188915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="147" mass="17022" checksum="BAB2D528B2B5781C" modified="2024-11-27" version="1">MPSKAEDILEGFKLNWMNLRDADSGKILWQGSEDLSKPEVEHEARVPKKILRCRAVSREINFSSVEPMEKFRLEQRVLFKGRCLEEWFFDFGFVIPNSTNTWQSLIEAAPESQMMPANVLNGNVIIETKFYDGDLLVSTSKVRLFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZT1</accession>
    <name>A0AAV6UZT1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutathione transferase</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_023368</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Mu family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000201">
        <property type="protein sequence ID" value="KAG8189861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZT1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042178">
        <property type="term" value="P:xenobiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000101">
        <property type="entry name" value="Glutathione S-transferase Mu 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF222">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="85"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8189861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="221" mass="25636" checksum="1CF5F05D46595B35" modified="2024-11-27" version="1">MAPLTLGYWDIRGLAEPIRYLLHHKNVEFTDKRYNFTSGEWPKDKFNLDLDFPNLPYLFDGDVKITQSTTILRYLAQKYGVDGKTQAEKLKVSMVEQQIVDLRWFMLMNAAFKENSEETRASVREKAPAMLKSFEKFLGDRKFLVGEGVTYVDFLLSDTFDFFRYYIPEICKKFQTLMAHQARIVGLPGIKEYLNSPTYTRWPVFGPIAKFGGGGPEPERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V037</accession>
    <name>A0AAV6V037_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000193">
        <property type="protein sequence ID" value="KAG8190140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V037"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="112" mass="12920" checksum="FB4F30E449B81D3E" modified="2024-11-27" version="1">MSKSQLCNNMDGRLPISRLPHPSSRKSVTVVNYDSIILEEYNIVCFTDGSKLNGQVDLAFVVYENRIEKETIQHRIPDDCSVFKAELVFEPCYKMDSKLSSIIRDCKIPHFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1G6</accession>
    <name>A0AAV6V1G6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000201">
        <property type="protein sequence ID" value="KAG8189857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1G6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF24">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="187" mass="21596" checksum="5815CF18A7CAF2DA" modified="2024-11-27" version="1">MTEEKEKVPELFPHERDNTKESQILLWIWNCLGENSCYDFDQYVRDGVLFCRLINYIKPNSVPGDIKAGANLKQKRENVSKFLKAIQSYGIPKEYLFEPEDLLLLRNLPKVTRCMFKLGKLADSDGNFKGPYLGDEPYEAANKSGRRRGGLPVGDDIYIAHVKLENVIKMLHTPPKKIVDFYRPLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1H7</accession>
    <name>A0AAV6V1H7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000183">
        <property type="protein sequence ID" value="KAG8190476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1H7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="136" mass="14919" checksum="C6FA240A0E7FC0A3" modified="2024-11-27" version="1">METAFVPFSPRMVMDWNCGGFFPHPKDAEEDARGDPSLTLLSVERVRYVLFVLKLLNGITCRFVLQLPVRDCETYMVLPKWVVLPMALLSPFAAPPVNDHPYSSLATPSGFQGVFSDTPPPPLVKAIQIAAGSTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V260</accession>
    <name>A0AAV6V260_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_009063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000199">
        <property type="protein sequence ID" value="KAG8189918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V260"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00435">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000084">
        <property type="entry name" value="Enoyl-CoA delta isomerase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="39"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8189918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="390" mass="43031" checksum="4BF832E46A4D50E8" modified="2024-11-27" version="1">MLLTGFRRTVFSSRRLLQTYTKLHPLQPAKVFVFEACRMGSSFQEATKKVKTLKEEPGNDVKLKLYALFKQSTEGSCKQPKPGMFDMIGKAKWDAWNALGSMSQEDAQKKYAALVDELSAETEQTEAGGTKEASKYEGISFTVAPHITEIAFNRPAKKNAITTKMYGDIILALKEAAQNDTALTVITGKGDYYSSGNDLSNFSQASGDLSAAAVKAAELLKEFVAAFIDHSKVLVAAVNGPAVGIPVTLLGLCDVVYASDTATFQTPFSLLGQSPEGCSSYTFPKIMGYSKANEILLFNKKLNATEAKELGLVSEVFPFNTFHQNVQEKLAFLSEASKQSLIYSKELSRGLEKPILHQINDLECKRLIERWQSPDCMEALMRFFTRKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3Q7</accession>
    <name>A0AAV6V3Q7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_001276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000177">
        <property type="protein sequence ID" value="KAG8190667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3Q7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039283">
        <property type="entry name" value="MOSPD1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34441:SF1">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34441">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MSP" evidence="5">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8190667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="214" mass="24128" checksum="0AED69B7D5246D60" modified="2024-11-27" version="1">MPDVDNLPVVTNPHEQITFYADDPSTHKQILTIYNPYEFQVKFKVLVATVGNVRRYAINIPSGFIKPHHSTDIVLKHLNVTSHNVGVLDKVRVSMSSNGNFRAVGRKDILVTLLDSAPRGRSTEHAGDSDVFEQLEVDSASLPHLRQHPLLHERQNNNKFIYIAVLVLGSVILAMPKEGDFSEYFPNFFPRPTSEMKYMITFLLGVISCLLLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6U0</accession>
    <name>A0AAV6V6U0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_016440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000154">
        <property type="protein sequence ID" value="KAG8191645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6U0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14277">
        <property type="entry name" value="UBA_UBP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
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        <property type="entry name" value="UBAP2/Lig"/>
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        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12478">
        <property type="entry name" value="UBAP2-Lig"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="12"/>
            <end position="33"/>
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            <begin position="104"/>
            <end position="142"/>
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            <begin position="41"/>
            <end position="78"/>
        </location>
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            <begin position="142"/>
            <end position="296"/>
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            <end position="547"/>
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            <end position="672"/>
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            <begin position="703"/>
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            <begin position="823"/>
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        <location>
            <begin position="1236"/>
            <end position="1275"/>
        </location>
    </feature>
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        <location>
            <begin position="194"/>
            <end position="203"/>
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        <location>
            <begin position="226"/>
            <end position="256"/>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8191645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1275" mass="135491" checksum="02E50C7322596BE8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7H1</accession>
    <name>A0AAV6V7H1_9ARAC</name>
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        <recommendedName>
            <fullName evidence="7">DM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">JTE90_019791</name>
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        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG8191855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF53">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="314"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="314"/>
            <end position="361"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="452" mass="49868" checksum="544AFF12B9E251B2" modified="2024-11-27" version="1">MKGELVSKSRKLIRDIENKRRISSGGSNSSQNMENGPLHVQQPSWSYHQERHFQLGITSPSSSYSRQDIENGVHLRHDVTYHHHHNQEHSRPTNTKKRRRSGSVSRSADPSSSFGYHLPDRGHQNRPPEDHHHPKLKKRPIPMDNNSSPGPKISPLQEGQMPKRTHSVMSDGPSPAKKSRPSSAASIHNGIDSIPPAVGAYPSDDADSSKTISSPPTVDSDPHHVEGMEVAIPESLQHPAGMELATMESQHAGGKELVTLESQLHAVGMVQQALEQQRPSGTELVASRGMDLQVANTTNNALVGGAAPQRLPKCARCRNHDVSSMVKGHKRYCRFKKCTCPKCILIAERQRIMARQVALRREQAQDEARKKQMQANGGKVLDNAGEVLVDSLPVPPPVQPLVAPVEQPAIEEPPVQQPVIEEPQPNPKQSAFRCLAINSKGMCRFIYQLSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7K8</accession>
    <name>A0AAV6V7K8_9ARAC</name>
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        <recommendedName>
            <fullName evidence="9">Proton-coupled folate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_009960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000143">
        <property type="protein sequence ID" value="KAG8192197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7K8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8192197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57444" checksum="DD10A55D57178042" modified="2024-11-27" version="1">MESPRGDISDVRAQTYSKLKDTSKDAETSEYGTADLKDNSSHLEHEARSPSKLSICWQTFLSLRIEPVMFLFMFSFILNTTCLTNMMMDKACLFYLNYTKAICDNLSDIRYKDERDEVEIVANNYNLYLNFLAPIGAFVVIFLTPWSDKYGRKPLLLSALFGFLANDIGIILCTVYFDSPLYFILVSNIPTQLSGGFICIMTVIYSHVSEVSTPESRSLKYTFLQIAFGVAVTLGALTGGQLYKHYHYLGVYYTMSAGHCIAIIWVIFFVPETRGVDLKVPLFQKFKDFFTSQNFTDGLKTCLKYRENQGRTALWLLLLSSCTIALTYEVYTDIAYVYAHHMYHWDPTMYSLMWTFFSFSEMLVVLILTPLLIKGFNLSDPVIGIIGSVSIICKNIFLAFAYQLWLYYVSNISGFLNGLGNLAVRSLISKLVLEEELGRVFSFLATCEAIVPLLGSAIITKIFNAAIKVFPGACYLAATVFLMLPLGTFIWQFKRNRSESGSFTEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAI0</accession>
    <name>A0AAV6VAI0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Zinc finger MYND domain-containing protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">JTE90_000242</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000118">
        <property type="protein sequence ID" value="KAG8193609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAI0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140006">
        <property type="term" value="F:histone H3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034243">
        <property type="term" value="P:regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20159">
        <property type="entry name" value="PWWP_BS69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000002">
        <property type="entry name" value="Protein kinase C-binding protein 1 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057053">
        <property type="entry name" value="MYND_ZMYND11_ZMYD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047268">
        <property type="entry name" value="PWWP_BS69"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048589">
        <property type="entry name" value="SAMD1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047269">
        <property type="entry name" value="ZMY11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057054">
        <property type="entry name" value="ZMYND11_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46379">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46379:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24324">
        <property type="entry name" value="MYND_ZMYND11_ZMYD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21524">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23461">
        <property type="entry name" value="ZMYND11_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52014">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 16" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAMD1-like winged helix (WH)" evidence="24">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="21">
        <location>
            <begin position="106"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="20">
        <location>
            <begin position="202"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="22">
        <location>
            <begin position="292"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="23">
        <location>
            <begin position="587"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="366"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="492"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS52014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG8193609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="27">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="74734" checksum="DF6BA7078470FF3F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBN0</accession>
    <name>A0AAV6VBN0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Ankyrin repeat and LEM domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_023715</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ANKLE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000120">
        <property type="protein sequence ID" value="KAG8193463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBN0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000072">
        <property type="entry name" value="Ankyrin repeat and LEM domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056237">
        <property type="entry name" value="ANKLE2_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF4">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24567">
        <property type="entry name" value="ANKLE2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="12" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="14" id="KW-1053">Target membrane</keyword>
    <keyword evidence="9" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="18">
        <location>
            <begin position="235"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="ANKLE2 third alpha/beta" evidence="19">
        <location>
            <begin position="482"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8193463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="90109" checksum="EBCF17D5E6DE2363" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDC3</accession>
    <name>A0AAV6VDC3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_028011</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000100">
        <property type="protein sequence ID" value="KAG8194697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDC3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000056">
        <property type="entry name" value="Dual specificity phosphatase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="13"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="11">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8194697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36616" checksum="4039F08DE2EA53DC" modified="2024-11-27" version="1">MDYFSWHKDYMVECDEIEPQLFLGNLEAAENEETLKCYGITHVLTVYKVPITTPKTIQIETLFIELEDSPDCDILSSFERSNAFIKEAQEKGAVLVHCYGGVSRSATLVAAYLMKKYSIGVDEALQRVKDNRNCACPNAGFLSQLRLYETMKYSLDEDNIDYKIFSLYHLGRQVSPGNDFNAIQTYLTRFKENVCDSRKFKCRQCRKCLFTQSNVIPHLKGQDLYWNNFAQLAVSEPPPIVCENSLFIEFLPWMMEAHQSLSGKIYCPECKSKIGSFCWKGQLCQCGATISPSFQVIDSKLDKDFQSSPPSGNECLLHHVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDH3</accession>
    <name>A0AAV6VDH3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDH3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="126" mass="13837" checksum="17CD20A361941357" modified="2024-11-27" version="1">MYLTHNLSMSNQARTIALSHVLPDSSEQINTSYSINIGPVSHFTCVHFIFLIFCFLLEGKLPPTFATSGEAPAGTHCDVMPGGAPWWIVPFGKIGAIFLRVIDLQDCPKWSALAVLGSWIIDTMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VE56</accession>
    <name>A0AAV6VE56_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000095">
        <property type="protein sequence ID" value="KAG8194974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VE56"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9549" checksum="AA0E19DF66237038" modified="2024-11-27" version="1">MDRLSITQEPPGQNLQSLHLIVFQKEQGLFLEQRGVVAAGVGVDQRVVEHSNIEGDSFHNPEAIYCSGKRINGIREQFPEAAATATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEW1</accession>
    <name>A0AAV6VEW1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEW1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11540" checksum="2C8AA5231400A949" modified="2024-11-27" version="1">MNSRDNFSLMRNRERRTVRGKIERRMKIVRGMESPLSLSLTPSMVHESPACQKRRLRPPSKMAASMAGARQDRHPRWQVEIDIFLARWQHGDSARAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFN3</accession>
    <name>A0AAV6VFN3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IkappaB kinase</fullName>
            <ecNumber evidence="3">2.7.11.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_017273</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19073"/>
            <dbReference type="Rhea" id="RHEA-COMP:13698"/>
            <dbReference type="Rhea" id="RHEA-COMP:13699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.10" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000098">
        <property type="protein sequence ID" value="KAG8194837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFN3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008385">
        <property type="term" value="C:IkappaB kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008384">
        <property type="term" value="F:IkappaB kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033209">
        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000147">
        <property type="entry name" value="Inhibitor of nuclear factor kappa-B kinase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041185">
        <property type="entry name" value="IKBKB_SDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046375">
        <property type="entry name" value="IKBKB_SDD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051180">
        <property type="entry name" value="IKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969">
        <property type="entry name" value="IKB KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969:SF17">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18397">
        <property type="entry name" value="IKBKB_SDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043764733" description="IkappaB kinase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="42"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="701"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="709"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8194837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="835" mass="96005" checksum="5E8F25584BE69303" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGP1</accession>
    <name>A0AAV6VGP1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000080">
        <property type="protein sequence ID" value="KAG8195697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGP1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="130" mass="14047" checksum="DA9A35E22B734CDD" modified="2024-11-27" version="1">MGGNLGPLVSEVSRSIYSPALSICLLLPRHSRTWSWHHSNSSQSVFILFESFWDIGFGTEVLAVRHAVGTMVIAVSQQKGLGKGVDTEVLAVSHRLFSCLVTLGYVAGTITGSQHLFTCRVILGHVELAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGT4</accession>
    <name>A0AAV6VGT4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000076">
        <property type="protein sequence ID" value="KAG8195942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGT4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="139" mass="15075" checksum="3D8B87D9386218F2" modified="2024-11-27" version="1">MPKRKYPIITTSENIGKYFCRAANMNKCESAATCTQSSDSSTLNTEVPKSSASSTSNTEVPKSAASSTSNTEVPKSAASSNLEANSAVEDSLPKKTYNFQQSWKTGRNWLVYVNKAMFCSICQAYDKGPRINAFRDGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGW1</accession>
    <name>A0AAV6VGW1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000077">
        <property type="protein sequence ID" value="KAG8195850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGW1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="11031" checksum="C613E619FB972E76" modified="2024-11-27" version="1">MENTEVLIYFLHTLAAFIALIIAASSVSKAFADVRQRTQILKLDKANTFEQLNFQSRAESEIHLIVWKLFPIRRSFALGTISAIFSYVILVDSLIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJS0</accession>
    <name>A0AAV6VJS0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF domain-specific O-linked N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.255</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Extracellular O-linked N-acetylglucosamine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_027576</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48908"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJS0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF148">
        <property type="entry name" value="EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="11">
        <location>
            <begin position="308"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8196864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="506" mass="59050" checksum="3D7A3F7597E4E2A9" modified="2024-11-27" version="1">MCATESEIYNVNLPPHHMPFFFASHQAEADACKNSPTCPYKNFMDLNNCWGYEKNCSSAFRYSSPSCNQSSKGWSKTKKEQSDTFYKQGDFGYIRERLDELTPLCSSDHEKGGVLECSKYMRFCRAKNIMFDFSTLKTLPEPMRYRDDVIREGQVSAYCKLKKKLFKQQGDHKSPLQSWYAEFEHFTELSIKLSNENCDVTISEPTFIMKLDATVNMYHHFCDFLNLYASLHMNQTFSTDIRILIWDTVPYFSNFEIVWKAFTRHPLQNLGQFKGKKVCFENAVFPLLPRMIFGMYYNMPLVPGCQGSGLFRAFTEHLKYRLKIKDNFQGSKIRVTLISRSTQYRQILNENELITSLKTFPDLVVRKVNFNRQMAFINQMEISYNTDILIGIHGAGLTHMLFMPPWSAVFEIFNCEDESCYADLARLKGLKYLTWEKSDKIYPEDEGHHPTLGAHAKFTNYSFDIPEFLRIFKKALLHVRKHFPVQKEQEKCIGSKCNHSVVHTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VK50</accession>
    <name>A0AAV6VK50_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000069">
        <property type="protein sequence ID" value="KAG8196521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VK50"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="107" mass="11775" checksum="692F06E5EF499A46" modified="2024-11-27" version="1">MPQADMVGKEVFNMKSTSTNVFQPIFVLDNRIRSPSVNSDPNTDRINSFFNSTMPQADMAGKQVFNMESTTAIASSNRFSSWRPGCSGRSATHFELLCASTEPSTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQ24</accession>
    <name>A0AAV6VQ24_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000035">
        <property type="protein sequence ID" value="KAG8198817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQ24"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="9914" checksum="6F944C2908E7D7D8" modified="2024-11-27" version="1">MANDHYHFPFSKCYPSPSLAPLHYRLSDAAVVPFPPVNMLGLPDLCVWTSPTISWGQSSGLTILRDLADDVGGGSRSSKRESCSAMGGGGETGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQ95</accession>
    <name>A0AAV6VQ95_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_001787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000033">
        <property type="protein sequence ID" value="KAG8198987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQ95"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000003">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8198987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="236" mass="26819" checksum="0FF9FAE766FF88EE" modified="2024-11-27" version="1">MKFLESSIFEAINSALRFQTGDCLIRGRIESYSCKMAGDHKKLFKIMNAESGPNDLQALSPPQSSLTATSPSKIFSRSQSDDGEGSQGPLCDTINRKTLSYLIATLNASFHPDYDFSHAKSEEFSREHSPRWVMNAVDSNLSATANNDYEALKGQLWSAIDHEICLPECDIYSYNPDLESDPYGEDGCLWSFNYFFFNKRLKRIVFFTCYSIGTPYCTENSEYDDEFMMEMDDSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRM2</accession>
    <name>A0AAV6VRM2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000036">
        <property type="protein sequence ID" value="KAG8198713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRM2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="21"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="189"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8198713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="353" mass="39929" checksum="6ED0832F7D4F65C4" modified="2024-11-27" version="1">MGGAQSLKHTATYCDGLPVDKYELVWTIPNVQKLLSSGVGFSTSTSALNLTVKEDTENFKVSLYPNGFNERVNGYVSLWLQKLTTKERLITFTCAIIGADGNQVVKKLTKQKMGVESFIGWMTFCPRNILIEKDFNVLKEDNLTLECSVHIFNEKALANPENEDESCENTVLSDLSNNLMSLLLDEAYHDFTMHVQGKKFSVHKAILGARSPVLKAMLRSKLNNSNSMTITDISEPIVKEMLGFIYSGKVGYLDFQEACELYYAADKYEIDCLKNICCNIIKKNVKVDNVLKALLLSERHSDIELQEICIQYVVENAPQVHELVEWITFLKSQPDLTSIIFRRLAQKKENTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRQ4</accession>
    <name>A0AAV6VRQ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_011773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000028">
        <property type="protein sequence ID" value="KAG8199305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRQ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="249"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="677"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8199305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1014" mass="112600" checksum="CE56BA5431F1CF66" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSD3</accession>
    <name>A0AAV6VSD3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_001807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000033">
        <property type="protein sequence ID" value="KAG8199010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSD3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8199010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="692" mass="76798" checksum="CDBB0DEE5209EA75" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT99</accession>
    <name>A0AAV6VT99_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Reversion-inducing cysteine-rich protein with Kazal motifs</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_009331</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the RECK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT99"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000011">
        <property type="entry name" value="reversion-inducing cysteine-rich protein with Kazal motifs isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056978">
        <property type="entry name" value="CC4_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056976">
        <property type="entry name" value="EGF1_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056977">
        <property type="entry name" value="FnI_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056979">
        <property type="entry name" value="FZ_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039016">
        <property type="entry name" value="RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055110">
        <property type="entry name" value="RECK-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13487:SF3">
        <property type="entry name" value="REVERSION-INDUCING CYSTEINE-RICH PROTEIN WITH KAZAL MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13487">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23332">
        <property type="entry name" value="CC4_RECK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25027">
        <property type="entry name" value="EGF1_RECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25028">
        <property type="entry name" value="FnI_RECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23298">
        <property type="entry name" value="FZ_RECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22961">
        <property type="entry name" value="RECK-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043921995" description="Reversion-inducing cysteine-rich protein with Kazal motifs" evidence="15">
        <location>
            <begin position="29"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="16">
        <location>
            <begin position="597"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="16">
        <location>
            <begin position="678"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8199483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="950" mass="106391" checksum="3E20CAF0B661ABB0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTA9</accession>
    <name>A0AAV6VTA9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Ras-related protein Rab-35</fullName>
            <ecNumber evidence="8">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">JTE90_000830</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Melanosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="8"/>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTA9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000404">
        <property type="entry name" value="Putative ras-related protein Rab-35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0168">Coated pit</keyword>
    <keyword evidence="23" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="14" id="KW-0967">Endosome</keyword>
    <keyword evidence="18" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-0636">Prenylation</keyword>
    <keyword evidence="17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00067828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAG8199735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="214" mass="24657" checksum="CEC879EC79C07C4E" modified="2024-11-27" version="1">MAREYDHLFKLLIIGDSGVGKSSLLLRFADNTFSGNYITTIGVDFKIRTLELDGEKVKLQIWDTAGQERFRTITSTYYRGTHGVIVVYDVTCGESFANVKRWLHEIDQNCDTVKRILVGNKNDDPDRKIVLTEDAQRFADQMNITLFETSAKENINVEEMFNEITRLVKKKMLLALKKFRNKLLFTATKPGYLLHSLYNTSILILEEICNLYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTT3</accession>
    <name>A0AAV6VTT3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000020">
        <property type="protein sequence ID" value="KAG8200070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTT3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="8838" checksum="66DD77DD0F76DE06" modified="2024-11-27" version="1">MKSENQLIFFDSISTLKLKMHRMGLIILFAMLMIISLSSECVCQIATGCPYNPSACISSCMINGESGYCSGVSCICNGIGSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUH2</accession>
    <name>A0AAV6VUH2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUH2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="9324" checksum="8F36061DA825CABF" modified="2024-11-27" version="1">MHSSENPRTPFRKQQQFAYFLGQRFASMKSNQQDRYRNIEIRTGSPISAIPDINPSISRGKWIASQEEDSFYKNGFCSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUJ5</accession>
    <name>A0AAV6VUJ5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000022">
        <property type="protein sequence ID" value="KAG8199963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUJ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="138" mass="15241" checksum="C91698BF34BECFE3" modified="2024-11-27" version="1">MARRLTEGLAADFRHATLLPFRSPNLVPDSFAAATTLFSPRRGLGQGSFVVWDKDADLLLRDDEADEDSAAAAMRQTSAAPAHNHPSRCFRHEPTGGARGRWRNKNRLKIPRAPLSQIPRGISRREDGDEPIILDGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWA9</accession>
    <name>A0AAV6VWA9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_000496</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWA9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8200408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="446" mass="50005" checksum="2A41A86120FF8CBC" modified="2024-11-27" version="1">MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAILVDLEPGTMDSVRSGAFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAEGCDCIQGFQMTHSLGGGTGSGMGTLIISKIREEYPDRIMTTFSIVPSPKVSDTVVEPYNATLSVHQLLENTDETFCIDNEALYDICFRTLRLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFITGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTAAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSSTFIGNNTAIQELFKRISEQFTAMYRRKAFLHWYTGEGMDEMEFTEAESNMRDIVSEYQQYQEATAEEEGDFEEGEEEEPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWD8</accession>
    <name>A0AAV6VWD8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_028557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000016">
        <property type="protein sequence ID" value="KAG8200376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052445">
        <property type="entry name" value="ZnF-G_patch_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17614:SF14">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 8-LIKE ISOFORM X5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17614">
        <property type="entry name" value="ZINC FINGER-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="G-patch" evidence="6">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="593"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="654"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1093"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1258"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1474"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1595"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1911"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2064"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2392"/>
            <end position="2532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2599"/>
            <end position="2649"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="654"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="737"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="816"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1114"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1144"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1264"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1288"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1305"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1356"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1394"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1424"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1478"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1522"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1630"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1654"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1677"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1709"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="2071"/>
            <end position="2083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="2085"/>
            <end position="2094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="2479"/>
            <end position="2494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="2498"/>
            <end position="2509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="2516"/>
            <end position="2526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="2602"/>
            <end position="2612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="2624"/>
            <end position="2649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8200376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2649" mass="296705" checksum="6B31D780F49D4430" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWU2</accession>
    <name>A0AAV6VWU2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_028764</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000008">
        <property type="protein sequence ID" value="KAG8201094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWU2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043596814" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="31"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8201094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="309" mass="33884" checksum="7532663ADF4FBD2E" modified="2024-11-27" version="1">MFVAKYFVLSVLTLTCLGKALCEDTELVDRIVGGRKAVANEYPFQASLLKRGKIGYFHTCGAALVAPRWLLTAAHCIGSNNTSDFKIMIGSNSLKNVTVENIYSVAKIVIKKGYDLHNFNNDIALIEVFPNVKTFDENDIKVAESPPHLNVTATVIGWGATSDGGSVSTDLQSADVDLISHDDCLDYYDYLSDSMMCAGFPDGEIDACQGDSGGPLIQIRSGVVYLIGIVSWGIGCAEPDHPGVYTNVAKFNAWIHHYIDATKILHSVNLYNRNLRLTCDKTLDFIWVRIAPTIHLCCTVLLVRVVMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXR4</accession>
    <name>A0AAV6VXR4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000010">
        <property type="protein sequence ID" value="KAG8200968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXR4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="10024" checksum="FCD10016D27C8778" modified="2024-11-27" version="1">MVVVLNHAEYHKKLIEGHDFPTAIVLLEANEIKDCAVVYGKHFIQCPQLSIISLLTLLLGVYFTMEINYPKEHVQAMGALALLVINDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VY76</accession>
    <name>A0AAV6VY76_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OCIA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_011255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000004">
        <property type="protein sequence ID" value="KAG8201589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VY76"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040187">
        <property type="entry name" value="OCAD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009764">
        <property type="entry name" value="OCIA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13336:SF3">
        <property type="entry name" value="OCIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13336">
        <property type="entry name" value="OVARIAN CARCINOMA IMMUNOREACTIVE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07051">
        <property type="entry name" value="OCIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OCIA" evidence="2">
        <location>
            <begin position="27"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8201589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="256" mass="29246" checksum="86ADC27F78CDDB0F" modified="2024-11-27" version="1">METDSPVVYHGTSESRFPPEQIKKTQVQLTPEEIRILRECNKESFYYRCLPLAVAGIASAFLGVRNGYLTGHPRWGPAGKMTGGAILGWFVGKFSYRSQCEEKFLKLENSAIGDAVRKKRGISRETFADESFSQFPEEEGTYKGDSYKPIRSDFNSSTASLNLDMDKNIQSVGLDDRNRPSTDNENANFGKDEPIQKITSYEDLRRRNREEYERQHQLQSQQRSGSSQMPPVRRQWGPFDSKQSKDTGRLKKILVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VY77</accession>
    <name>A0AAV6VY77_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VY77"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOCS box" evidence="1">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="290" mass="33939" checksum="538788AE05136BFF" modified="2024-11-27" version="1">MENLLRNFAPGVHIYSPFSKSPEQDPMPTLQKLCRNAVLKHVTLRRLTTGETSLHLPKRLWKHIAELSTADLKLIECAPTDAFNGYFFYKALTYKVLCLCDEQQYMVTYGYSKNGEVKKKADHDQWVKIRHKNFLSVYATVTDESTQNVFYIYDQPHTSLEELWEKICEKQIPVPDAFFIRLTSDLYEALLFLISKGLQRREFCLHNIYIMNDRLVLENGSMCKALKTESSNGEYMLIEILKLLLTKDSFHSKTVWKWIKKIEYHKCFLRNLNENGNSFSFGKLIQNLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZU9</accession>
    <name>A0AAV6VZU9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000009">
        <property type="protein sequence ID" value="KAG8201071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZU9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="7817" checksum="849B813F740610A2" modified="2024-11-27" version="1">MSSTSAVGPLGHIPIWDYPGYLPAAAEYVIAAVITPIPDDVGSYFLSNLSRPHVRPANLTIQLDEDNPKRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W1C7</accession>
    <name>A0AAV6W1C7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_027419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W1C7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF2">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="617"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="41"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="131"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="224"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="311"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8201943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="708" mass="79229" checksum="D158F44B4A1DFF8D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W3E7</accession>
    <name>A0AAV6W3E7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W3E7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="8771" checksum="BED29894C9D1C2B8" modified="2024-11-27" version="1">MSKKEKKTPFLFLVIHRTPYGTNRTTKDPDNPERSHSFFEKSGQESFPYRLHPVSGGHCCQPSGHATAIIEGPEATAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCM8</accession>
    <name>A0AAV6TCM8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007693">
        <property type="protein sequence ID" value="KAG8155644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCM8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8441" checksum="B2A0FEE009A8FC53" modified="2024-11-27" version="1">MKVQAGGGRPHWDPPSPRAGRTGDPPRPLGKWRIFSDTLGPKEVKIARKDEARGNWWRSLAVLTCKSSSDWVSGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCP3</accession>
    <name>A0AAV6TCP3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007522">
        <property type="protein sequence ID" value="KAG8155656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCP3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8155656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="126" mass="14015" checksum="943826CC2AFF8D9E" modified="2024-11-27" version="1">MPCRHGPLYRICFLSREPLNKALAVATERKSVPGCFKNSLFKPKNAGQTTMIFPPLNPLGLPYFPTPVVVWGRFKTIFDNDPSSYSRFGSRTVEKSHVQKVGIGWTGPFVSPFKGSAECPQKKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCQ2</accession>
    <name>A0AAV6TCQ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007369">
        <property type="protein sequence ID" value="KAG8155670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCQ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8155670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="9833" checksum="4C1078C9F2D69927" modified="2024-11-27" version="1">MWRLGGACRRRTLQHSPLTGAVAQRGARPNSCYVLSGSISLESGCLEVQHPLSCGKLHLRLNTSVRPIANKYREGKLQRTLKREFKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDT1</accession>
    <name>A0AAV6TDT1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006337">
        <property type="protein sequence ID" value="KAG8156080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDT1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8156080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="106" mass="12070" checksum="763D6D45A9FB9CBC" modified="2024-11-27" version="1">MQRGGIRVTNRDNWLVRGQSVHSDITFDLQMSATILSMRSRIRQAVGLYHPLIGKRRAGFRPSRDRLVLTTDDCRRCDSKSCQYERNRSSDTLVIAWSRSASGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEU7</accession>
    <name>A0AAV6TEU7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005829">
        <property type="protein sequence ID" value="KAG8160100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEU7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8160100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11705" checksum="995A5EC2396022C9" modified="2024-11-27" version="1" fragment="single">SEAPDPALQLAHDISQRNAVIYIVVVLFFYSFGIGIMMIKYMRKEAEEQEEFKMYRRYLNDSKDTPADAMSRGRLANRLALQALNMVNVIPQTSLAGSKVTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFV4</accession>
    <name>A0AAV6TFV4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005046">
        <property type="protein sequence ID" value="KAG8170678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFV4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="146" mass="15640" checksum="A927E94AF843D068" modified="2024-11-27" version="1">MGKPFSTSPQGSHLVLLLPPNLHGGGSRRGHAGPSKAPHRDPPTHCGVKPPRGNSAERPGKPPLLNVIHFRGSFLRRVLFLHGFLRENIYLRGSFPPIKVPFSQQPTPKGDPHRIAPNPLGLAPFWGNAPVKGEIAAESVSGTLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFW8</accession>
    <name>A0AAV6TFW8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005099">
        <property type="protein sequence ID" value="KAG8170638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFW8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9635" checksum="8AD02D2814623AFD" modified="2024-11-27" version="1">MCASQWVLNKPGGEKKDRPAEVGPFGIPVPRGRGAPETPAFPLWKWRSLAHTLGNPKMGNYARTGEARGNLVEVRRVLTANRSQIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THE4</accession>
    <name>A0AAV6THE4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004328">
        <property type="protein sequence ID" value="KAG8171176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THE4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9232" checksum="102A703B64FA3954" modified="2024-11-27" version="1">MCLRFGRRLVGKRISPIPWPRAPMFNCFSREKPFPSQSSRGPTLVFVLPPRSAPGGGPGGSRPAPSTHATGPSHSRGVNLTREALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THJ7</accession>
    <name>A0AAV6THJ7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004284">
        <property type="protein sequence ID" value="KAG8171224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THJ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="11854" checksum="56E87F5C4C428BCC" modified="2024-11-27" version="1" fragment="single">MGLAPTLGNSPGQGDLLQSPSPARSLLNATFPHALASGGFGAGLLPEKAFPPSRDPHHQRAPVFDIAQKYCHKIKYETSHSRQTVLDSPRPALHIAAARKQKRVEKGRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJP1</accession>
    <name>A0AAV6TJP1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003614">
        <property type="protein sequence ID" value="KAG8171731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJP1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="842" mass="92156" checksum="81C1CC3AEDC3910E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJW4</accession>
    <name>A0AAV6TJW4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003305">
        <property type="protein sequence ID" value="KAG8171981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJW4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8750" checksum="6BA8CB14F915C6CF" modified="2024-11-27" version="1">MAIVRRSKQPTPFMGSHERPRTAPLTGVLFIRQRHSALPKVAHWALSPVSSASVMQSCGLLTHLKFENRLRSFSPQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKR3</accession>
    <name>A0AAV6TKR3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_025416</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010002886">
        <property type="protein sequence ID" value="KAG8172281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKR3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="89"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8172281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="214" mass="24633" checksum="128A613704ADA8CD" modified="2024-11-27" version="1">MAPSGTWVTEEVKKAVEKGYVILKVHEVYHFSKSSDSLFKTYIDTFLKTKQESSGWPSNINTEEEHTRYLDDYLSSEGIQLDPSSISLNPGKRAVSKLALNSFWGRWGMNRDKNQLTYIRTLEKFNKLLSDNTKTIEELYFPSENVCVVQWKLDEKFLGQDVTTNIFIAAFTTCHARLKLYSEIEKLDRDVLYFDTDSIVYRSTGVYGCADATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMQ2</accession>
    <name>A0AAV6TMQ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002408">
        <property type="protein sequence ID" value="KAG8172756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMQ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="130" mass="13893" checksum="E7962A986CD93046" modified="2024-11-27" version="1">MSVRGTWSDHPGRRDLAGMGRRCVSRGGAPRGHQWDTPPGSTLRAACSGAGKPGTQSYLRSARRASRGRPHGLWWGSEPAPAAQLGLACSAVSGGGVVRRGRVLALADRMAVQEEGPARHRRRCRFKAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TP48</accession>
    <name>A0AAV6TP48_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001510">
        <property type="protein sequence ID" value="KAG8173745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TP48"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="341"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="398" mass="44133" checksum="29B2A8E5E88E9FD2" modified="2024-11-27" version="1">MPQSSGSVNTESNHNLSEKLVCSSEVQVRDQGRLVSHQQDKLNEYEVFHNATSIPVPKPYTCVFTINHDEINMEIDTGCAMSLINQHTYKKLGAPALLPADTALSTFTGQSILVLGTISSNVGYKNQILKLPLLVVEGEGPNLCGRNWIELFNILPVSSCLSVSHENSIESLLNNDNDVFSSELGKFKDYQINLIVKPDVQPSFYKARYPTIAVRDKVKDELQRLQDVGIIKPVRYSQWAAPIVPVLKSDKTSIRICGDFKLTANIAIDPDQYPLPKADDIFASLAGGIQFSKLDLKNAYNQLELDEASRKFTVINTHLGLFEYVRLPLVCHLRQQSFKGVVSTYDPSKELVLACDASPYGVGAVLSHSINGEDRPIAFASRTLTPAEKNYAHIEKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TR92</accession>
    <name>A0AAV6TR92_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001314">
        <property type="protein sequence ID" value="KAG8174114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TR92"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="124" mass="14181" checksum="8BD014F6D21D3CD0" modified="2024-11-27" version="1">MAAAHEKTDDGVCLPKKILSKLIVDCYLTSDDQFCNSHRRKAFRVHEEYASIIGTLCREQFVLKEIQRAACRWKDVKYEMEPSDIGNVGCQRCRLALVAMQQGVQPTAWSKMYKRRTNVLRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRY8</accession>
    <name>A0AAV6TRY8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001144">
        <property type="protein sequence ID" value="KAG8174777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRY8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7550" checksum="4855099F2C4FC1C2" modified="2024-11-27" version="1">MSEEMSSDTYCRYVATGVLCSYENVSRDPPGTRSPSGRVGHPPQSRLSSENEASFIRYWPPQSTFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TS69</accession>
    <name>A0AAV6TS69_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_026660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010001147">
        <property type="protein sequence ID" value="KAG8174760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TS69"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8174760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7643" checksum="715952317819FB58" modified="2024-11-27" version="1">MIPRKALEIIDRTLKNVMNNSLPFGGKTFILGGDFKQVLPVVKKPPEAKLSRSASNPHTSGNSLKLIISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTH9</accession>
    <name>A0AAV6TTH9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001103">
        <property type="protein sequence ID" value="KAG8174956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTH9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="140" mass="16354" checksum="F7911EAAC03890F3" modified="2024-11-27" version="1">MERYGFLRKSTADPDNIISVHDDLFTDIGSCVRAGSAQEQNLESTIYYFKILNNKEVVDYIHNNCEFLCVFSYFHLYRPSPHKPYSMSTSCDRLFSQLLECVLSAKCKPKEADDPIGHRLKVAYYKLFSDDELIKELHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTL7</accession>
    <name>A0AAV6TTL7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001116">
        <property type="protein sequence ID" value="KAG8174918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTL7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043630510" evidence="1">
        <location>
            <begin position="26"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="205" mass="22291" checksum="D88237913FBFE108" modified="2024-11-27" version="1">MIISQSMLFTAVAAVLVASLGPVAADDGGCKDGGVESFSAGYYTANVGFHEESMLGITLGGGEAGMKLFKVVKQCLEDHQQCNADSVAYTFGQALARARSVSLRGYFKHIALTVGRSLFKFGILNCSNSVALSSEFLHFGMVEFDKYPKDLYNFKDYMDTSVYALVDLVLAHGISLEDTAQDIADTFYETYRDEQPDCKFGKSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUT5</accession>
    <name>A0AAV6TUT5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001012">
        <property type="protein sequence ID" value="KAG8175398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUT5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22955:SF77">
        <property type="entry name" value="ASPARTIC PUTATIVE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22955">
        <property type="entry name" value="RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="164" mass="19176" checksum="90AAA37AF1779113" modified="2024-11-27" version="1">MFLNEHMALVCTPVKLLTVPRRSKLDKGRPQALENICLQQNNRILQHTTPAQWHHCPDTDNPADHLTSGTFPSQLLSLESWWQGPKWLTDVPENWPIKHLSYHPLVEVETRKTESQSFYVATTEPIIDMSRYSSYTKLLRVTAWILRFVHNCKSQQHILRFDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVE1</accession>
    <name>A0AAV6TVE1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000979">
        <property type="protein sequence ID" value="KAG8175626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVE1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8211" checksum="95EE0B00BFDB7302" modified="2024-11-27" version="1">MKCSIKAHENARWTDTLPIILLGIRTAFKEDLQATSAELVYGKSLTLPADMFHQPDCKEKLDDTYVTNLRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVH6</accession>
    <name>A0AAV6TVH6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000950">
        <property type="protein sequence ID" value="KAG8175763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVH6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="7941" checksum="35885E674E398633" modified="2024-11-27" version="1">MDLGRSLGRGRSRHSPNLTDDQKLAALTPVQQPRTVCLAGLLASVRFWGPQGQGEPSRALPASPRAPPPRSSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWX9</accession>
    <name>A0AAV6TWX9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000948">
        <property type="protein sequence ID" value="KAG8175831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWX9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="130" mass="14670" checksum="1AC436437672BF59" modified="2024-11-27" version="1">MLLKENSDSFISMVSPVQEAESSSASNDGLVCVLEDESHVETPSTSAQPPTKAEPTSADWLKRKRRPNASLRAAEALSAAASARRAVVERESSREIELMEIEHQRRMLLIEEQILTERAKRVYYKRENKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXN7</accession>
    <name>A0AAV6TXN7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000862">
        <property type="protein sequence ID" value="KAG8176609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXN7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="343" mass="38864" checksum="BE5AA3436F6F10FC" modified="2024-11-27" version="1">MFVVAVENKVADKDEEPCGPIIIVRASWLTPKKQECFWPPCKLSDKFNSTLSKTEVPGEKWTLIKIKKRLYETDDLVKARKKAREAEIESDLLTDDPPEDTSSQRKSKRKRKRIQFSPQVSDDGSSESEPQRDLDIIHMPDPPSCNLLGIQINDSFLFIIRSTTVQQYWNKQYHHLPSQPVNTPIAESSPLRHYHSDQPTHNIGSSPIYLPSQPVYTPTTGNGPIHPDPGFKVLLRRIENLTEVVQENNKLLHALLVEKKAAEDSPQVNKDCPFTLPLQSIKDVEDIEDLLKDSENRKNFNLSPLLDNNNSAEQFHSIVAKFVGGKRINYPSVAATMPDITVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXS7</accession>
    <name>A0AAV6TXS7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_018705</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000840">
        <property type="protein sequence ID" value="KAG8176922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXS7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:steroid hydroxylase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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            <begin position="6"/>
            <end position="27"/>
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    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="472"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30413"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZ75</accession>
    <name>A0AAV6TZ75_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">JTE90_027157</name>
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        <name type="scientific">Oedothorax gibbosus</name>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAG8176851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZZ5</accession>
    <name>A0AAV6TZZ5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000821">
        <property type="protein sequence ID" value="KAG8177092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZZ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8790" checksum="22258C5B80CE6612" modified="2024-11-27" version="1">MLTGSRQHILKIHCWRTNDNGSFSSIAYCTRPSPPSWVEKGKYLVEAFDDKTEISSGLKGVVGVKSSEVSFIKECYWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0I5</accession>
    <name>A0AAV6U0I5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein furry</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_002529</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000788">
        <property type="protein sequence ID" value="KAG8177302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045842">
        <property type="entry name" value="Fry_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19421">
        <property type="entry name" value="Fry_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="151"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1209"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1414"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1654"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1809"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="2060"/>
            <end position="2310"/>
        </location>
    </feature>
    <feature type="domain" description="Protein furry C-terminal" evidence="5">
        <location>
            <begin position="2346"/>
            <end position="2550"/>
        </location>
    </feature>
    <feature type="domain" description="Protein furry C-terminal" evidence="5">
        <location>
            <begin position="2611"/>
            <end position="2938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1763"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1957"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2373"/>
            <end position="2401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2537"/>
            <end position="2601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2826"/>
            <end position="2845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1539"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1586"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1764"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1973"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2373"/>
            <end position="2383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2384"/>
            <end position="2401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2566"/>
            <end position="2576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2835"/>
            <end position="2845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8177302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2955" mass="334417" checksum="8BB9F0D1A5D0A689" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1C8</accession>
    <name>A0AAV6U1C8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000748">
        <property type="protein sequence ID" value="KAG8177816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1C8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="126" mass="14035" checksum="12B7D27FD9660BAC" modified="2024-11-27" version="1">MQHGAFLQEWDYVHIFLSSILKDRENLHTNPSSLALDVNVPVNSTASMDIELEVVTTPPVINRVPDVTPPPCYGLLLDVDDAVNSAATMYFEVLFFTGICWVLLLWQPKASWQATVKRPPKITPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U289</accession>
    <name>A0AAV6U289_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_026276</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RING-box family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000703">
        <property type="protein sequence ID" value="KAG8178305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U289"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="109"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8178305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="164" mass="18762" checksum="1F453B176C9108B3" modified="2024-11-27" version="1">MQNDVHPINLVAPVFGLSVQSRCSETTGSLQKFVRILLIFFCEADNNNKMTSMEVDDDIDNEAESSSASTSRGEKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2M9</accession>
    <name>A0AAV6U2M9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease P protein subunit p29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_017652</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000749">
        <property type="protein sequence ID" value="KAG8177791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2M9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8177791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="234" mass="27248" checksum="143CBE068C3F865F" modified="2024-11-27" version="1">MGKAKNKKDQRKEESKNPLFKGLPPAIEKLSERIGLRKVPESYIKKFIKDVLPSTNTYALDELKHYVFSFDKYKKRRTAIARKKRKTLLNASEQRRLATYKLDPTTTKFHTFVPIHELWKQYMHSMLQLKDPLPSDLSNTYQKLLKADYHGCMLVVVSSNCPNYVGKSGIVIQETKNVFKLVSKEDKIKTIPKKGTVFCFELDGNVFKIYGGNFCYVPYERIRVKFKTKNLVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3I1</accession>
    <name>A0AAV6U3I1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_024647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000693">
        <property type="protein sequence ID" value="KAG8178487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3I1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043361245" evidence="2">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8178487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="102" mass="11682" checksum="317C7CCB7DA30FC2" modified="2024-11-27" version="1">MKISLFIAFLLVLLAVVFADSTQKNAEVDDSTSTSNRFQIDSRFQTDVEPRPESETEVNSKNFPPIWNPHWNFPTSSESPSTSVVPPFPPIPMKCHWPYFYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4H3</accession>
    <name>A0AAV6U4H3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000689">
        <property type="protein sequence ID" value="KAG8178524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4H3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="30223" checksum="3CAD4A5CB0E250B7" modified="2024-11-27" version="1">MAPNKLFLDKEQKATTHAEARGIMKQMESVEMVMMMFLWIDILERFQPVGKILQSVDIDLSRAVQLLSSLTLYLEDIRSRFEDYEKMAKEVAINLSSKEESRIPRKHFKTIYDGNAPETVLKPTDKFKVETFLPIIDQLQTELHDRIKVYELLEERFACLHKFKSMEIGIMKEKAEALAKTYPKDLSIDIVNELNHLNYFITEDCFTDENPLTARSLLKYIINKGVVCIFPNVVIALRIFLCLFCSNCTGERSFSKLKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U568</accession>
    <name>A0AAV6U568_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000657">
        <property type="protein sequence ID" value="KAG8178948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U568"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="191" mass="21992" checksum="5AB932D1C6B0CFA2" modified="2024-11-27" version="1">MLTILCSWMFLEIGKSLQQCEKMLLDGCPLEHLYSSYSNVFRFKTSMEKSLGFIILLLNLSGFFTVFTSLSSILVEDNEQFVEREFLLTLLFHMIVRSTYLVIFFFSAANINGRDKSFRIAIFSYSLSRTNEKLDPIFLTSVNDSTSLSFTVCGFFELTRGFNASAIGILLTYSMLFLQLEKKDKQEDQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5W8</accession>
    <name>A0AAV6U5W8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000639">
        <property type="protein sequence ID" value="KAG8179283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5W8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043529407" evidence="1">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="113" mass="12238" checksum="D77A0630A190D0D9" modified="2024-11-27" version="1">MGLLIRASFLLVVLCSTLEFSSAQASLGGFVPVGTYSRRSSNGDNEFISSVGNAKVAVYRKEHRQPRPLAVVPLPVPVARPVPRYPPLVESEKARLSMQAFAGKKEEISGLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7M9</accession>
    <name>A0AAV6U7M9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_007048</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000599">
        <property type="protein sequence ID" value="KAG8179868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7M9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="11">
        <location>
            <begin position="40"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8179868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="723" mass="82070" checksum="42F2EB71D9C9255F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9V8</accession>
    <name>A0AAV6U9V8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000559">
        <property type="protein sequence ID" value="KAG8180638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9V8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="188" mass="21503" checksum="BFE1F85DE8E4E646" modified="2024-11-27" version="1">MEVVIHKLAEKMDIKEVPLIQPGVGGKEKLKKRPAENSNNKIQLKKQKSINENMFKEVKQRILSAKAVQATTKVVKNTEVVKKHVTPCSFEHETQVLQLTLLQKEAELLEKGNELAYLQAKYNEQEENFANLKNKSDLLAPNDNRLDTLLPAEPHENMYDEDELSNEEEELSLNAIGIHHPQGWLIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAU2</accession>
    <name>A0AAV6UAU2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_007756</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000520">
        <property type="protein sequence ID" value="KAG8181349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAU2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000065">
        <property type="entry name" value="Transmembrane protease serine 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="11">
        <location>
            <begin position="103"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8181349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="476" mass="51633" checksum="056DA07E956F3CBA" modified="2024-11-27" version="1">MLALFPQLDNPAFYQEESDIGRSRKEAEDQDHAYSIQEAELDGKGVERRWRRFGGRVVMLVGAICVLLAVLLAMVAAVVYLAVGEVRTSWQSEHEYREAEEGLVSVVEGRLRITNRVFTTDLLDSHSAAHAQLSSHITQAMDAVFLHSLQNYNQTQVLGYRPGSVVASLRVHLVRGRRDAPHAVGMAVVGALERHHGYLPGGRLQVDIRSLHFASLPDPEDEIIPIVKTVEEPINKVVPAPPTTTTPAPVTEEPEVSANCGGVVCPEGRVCIFLPPSSLARCLEPRDASDPTGCGGWCLTEHQVCRRAGNETYQCADNSASLCPEGEWRCGNGLCVGVAQRCDGRIDCYDMTDEMDCECGVGHFRCGGGTPCLPDHVVCDGHVDCWDASDEINCTRASTCIEGQFTCNDGTCIRSDLFCDRFADCPDKSDEPSGCGDSCLGSRQCGNGRCVADKLWCDGADDCGDASDERACLMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBA1</accession>
    <name>A0AAV6UBA1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_001467</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000494">
        <property type="protein sequence ID" value="KAG8181812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBA1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF22">
        <property type="entry name" value="SI:DKEY-35M8.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8181812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="274" mass="31265" checksum="3CFE5059074282D2" modified="2024-11-27" version="1">MYKELKGYFKPSRPSTPSSDYIILRPPPTWCLHTTKDTINHKHCTNIEKWETSVTVTTLWTILSILVTITCTIGFVETEWLVRENNTLVAEDRELTILTYDRSSLVYTLGMFNMCYRDMKQTSFHCHRFGVTRFPSVSWQGTCILYGTGCVLQGCGAVLLLMSLMYKGDVRRIGAHLVSHAYVLAGLLQTLSLLLYPLILDTHVGRLHCGPEAHAYGPHLCRIGWAYVAATAGTLLTFYCPFLAYFSFYRTYDGHQLTYYDMQEDITIKPKAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBZ3</accession>
    <name>A0AAV6UBZ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000490">
        <property type="protein sequence ID" value="KAG8181882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBZ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="10036" checksum="E966B4F7EF225431" modified="2024-11-27" version="1">MNGYYYILERVKKKLPNTRPKPRLQSFPIPRRVVGGYSRKPPPKIPSSFGAFEEPQNSSSHLERSSRGQTVPLCPAKKGPNFRGTGPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCF4</accession>
    <name>A0AAV6UCF4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein soc-2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein soc-2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">protein Sur-8 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_023602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a Ras effector and participates in MAPK pathway activation. Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulate Raf activity at specialized signaling complexes upon Ras activation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000492">
        <property type="protein sequence ID" value="KAG8181864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCF4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000031">
        <property type="entry name" value="leucine-rich repeat protein SHOC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000115">
        <property type="entry name" value="leucine-rich repeat protein SHOC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000281">
        <property type="entry name" value="Leucine-rich repeat protein soc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000450">
        <property type="entry name" value="Leucine-rich repeat protein soc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="273"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="507"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8181864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="645" mass="70936" checksum="D933832B8D94F171" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCL6</accession>
    <name>A0AAV6UCL6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000519">
        <property type="protein sequence ID" value="KAG8181361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCL6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043641726" evidence="2">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="234" mass="26928" checksum="779A45F0698FE850" modified="2024-11-27" version="1">MLLGLILCIILTLRQRAKLGKDLSNFFLNHSAVAGDKRLAGRGGKLMHVKALTGRGYERRASSLIGGLRQSPDTECRAKLHCLALTRSFREKVACYYIEAQLLRRTLTFQNNVLLLSQKEGVVLTKKRKYCWNKGSPFKHWKQGVKIIKKTLSEKIKKIPPTTQRMQILFRQGDEVIGRKIDYSTPRRSEVIRRIQPMGNLGNAHKITSTKWRKQRQREKDQKIEQESGGCNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDA1</accession>
    <name>A0AAV6UDA1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_014358</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000485">
        <property type="protein sequence ID" value="KAG8181979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000075">
        <property type="entry name" value="Putative zinc finger protein 536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1146"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1197"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1225"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1282"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1310"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1338"/>
            <end position="1365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8181979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1375" mass="154972" checksum="CB18B097D9BDC34C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDM1</accession>
    <name>A0AAV6UDM1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acidic leucine-rich nuclear phosphoprotein 32 family member A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_026898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ANP32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000486">
        <property type="protein sequence ID" value="KAG8181958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDM1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000003">
        <property type="entry name" value="Acidic leucine-rich nuclear phosphoprotein 32 family member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF0">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8181958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="250" mass="28151" checksum="0BEA7CD640520385" modified="2024-11-27" version="1">MEKRIELEKRGRNPSGIKDLVLDNCRSTQIVGLTDEFSALESLSLINVGLTNLKGFPKLSNLKKLELSDNRISGGLNHLSGSPKLTTLNLSGNKIAGLEELEPLKDFANLKQLDLFNCEVTGQENYREKVFALLPGLVYLDGFDVNDKELEDSEEENGTHDKFPDDVDSDEDEDEEEDEDEDDEDEEDEEEGEVGLAYLQNQQIDEESEGEDYDPEGLNDDSDVDIEDDADEDDKEDKARGQKRKLEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEL0</accession>
    <name>A0AAV6UEL0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">JTE90_020426</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000461">
        <property type="protein sequence ID" value="KAG8182511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEL0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8182511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="353" mass="40731" checksum="9D5088A0F0626795" modified="2024-11-27" version="1">MSNFKPSTYPCTRRSKTDNFVFQLHYRWTVILLVFCSLVVTCRLVLGHSFSCHENEATKKVNLETKCYAEGIYSMPFHSAKTASGPSGSPKPEYRRHQTFYRWVNLFLLVQAALFYFPHLVWESYESGRLERLTRRLDSIIIDDRRAKALCHLAAYVINNQGTHRTFTGVFIICEVLNYVVSLSQTLWLVHFFEVTGVPESVNFNITTWSDFEKFYFPESGTCLDFPRSSVVHCFLPLNKLYMFIFLFVHAWFIFVTCLSGAVLVYRLVLLAPAQRAVILRMSCPGLDSLGKHISYSDFFFLTRFQKVMSDVDFGDMMDKMAAISTGDMVRPEEDFKYVDTLSKSSEAEESPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGA3</accession>
    <name>A0AAV6UGA3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_018652</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000448">
        <property type="protein sequence ID" value="KAG8182778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGA3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000004">
        <property type="entry name" value="Chitinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="14">
        <location>
            <begin position="132"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8182778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="497" mass="55874" checksum="368E2A46A52E4A8A" modified="2024-11-27" version="1">MAIRLGIYFYMRSIFLYIIFVSGLTWIREMARVKMTYLLGLLLLMVVTESNAQVSSSCTKKDRAAILLDAANDFISKATDTPPTCLFGFPHSDYTAYNIETAKPSTLLETASSLVTAAKNSYSSKTQEGGNYKLVCYFSSWAYYRKGEGRFDFSGFQPHLCTHAIYALAKLEDNKIVSLHPDIDLPEYMNGYKKFNELKQKNPKLKTLLAIGGWAMGSAPFSMMAEDKTKRATFIESVIPFLQEYGFDGLDMDWEFPSANGGRSQDKQNFVILLQELKEALHAKELMLTSTVSGVRYFIDTAYDIPGISKELDQIHLLSFNLHGAWQPFTGFNSPLYAPPQASMEDQELTVDFAVNYWLNNGAPKEKLILGMALFGRTFTLANPTENGVRAPANGAGARGRLNGDAELLGFNEVCYNLYKLRWASVWDPDAWTPYAFKDNQWVGYDDQRSLNAKVDYLMRKGLGGGLVWSIDSDDFRGHCYGKKYPLLRTVANKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGZ9</accession>
    <name>A0AAV6UGZ9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000415">
        <property type="protein sequence ID" value="KAG8183484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGZ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="822" mass="94458" checksum="927D5CCD2557CA48" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHA7</accession>
    <name>A0AAV6UHA7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_010897</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000433">
        <property type="protein sequence ID" value="KAG8183073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHA7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="6">
        <location>
            <begin position="31"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8183073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="118" mass="13367" checksum="4AD10E7468B0D9B8" modified="2024-11-27" version="1">MEGISPEGMDEQQLDMYWRGASVELINKHRVLVFGKSTCPYCIRVKDLFKKLGVEFFAYEFDQEGDDGLRMKKAMHQYTGKTSVPQVFIKGKHIGGCDDTMSAHDKGEIQKLLQNGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJJ1</accession>
    <name>A0AAV6UJJ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_008985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000378">
        <property type="protein sequence ID" value="KAG8184300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJJ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043099097" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="21"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8184300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="581" mass="67133" checksum="2A724FE5BE10B0D4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UK57</accession>
    <name>A0AAV6UK57_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000386">
        <property type="protein sequence ID" value="KAG8184134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UK57"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="140" mass="15518" checksum="A5ADE3790E857A49" modified="2024-11-27" version="1">MDRDYLVVQAATRRPRVMSTKPKSKLVLKLALFLVALTGLAFLAVAVVYLVFDLQQKRFVYLYIGLFLVLEGVVIVISFWPKACQVLRPKSSMSQAQGSHPVLSEDLIENLDGVEPSSEVSPHTSDSAPHILERHVTTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKR7</accession>
    <name>A0AAV6UKR7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000380">
        <property type="protein sequence ID" value="KAG8184273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKR7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042984">
        <property type="entry name" value="BBS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46883">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 12 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46883:SF1">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 12 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="439" mass="49434" checksum="24306F005BEECDC3" modified="2024-11-27" version="1">MSVLLKQLVGSIISSYLGPIKSNKVVLDCEDCTMVKCPLEFLKKIAIKDPFSSLLENTLDSHHEQFGCSTMSLLAMWQLWQEEFKLAMEEGCEVQDIIEFSQKTLADVVSALSEVIIDCDKTCLSKLKITKNTSIHLNQPYFQNKKNTKSALVKTYNAPKELSSLGSVSIGYSSRHFSPFSSKSEEKSVNDFEKLTGEKNGDNLISVTSEMRKEMHSLVEKLSHDERDFIDLICNLWIQQVQSRNSLEFTINGICICPATLPCSNCTVVDGVIIKSNLSLLYEQDLGSFENCRALIIKGSILFEYVHLGYVSKVSITLKETTESLKISQKDEWIEKCCKLLMELQINVLLVNGEVDSSILSFCSAHSILVLPSVPWKTLEILCISVHESPCTYLIDCDEDNIVTNLVVKKWDFVSSKMLVHGEYYHIDTVKVCKTVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULX4</accession>
    <name>A0AAV6ULX4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_022679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000367">
        <property type="protein sequence ID" value="KAG8184631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULX4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF48">
        <property type="entry name" value="CENTRIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8184631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="169" mass="19223" checksum="5B7434CB24CC4ADB" modified="2024-11-27" version="1">MTSSRKSSVGGAKKKSNAKIELTDEQKKDIEDAFKLFDTEETGFIAARELKVALRALGFEPKKEEIKKMLTEIDKDNTGKIAYEDFFSVMSVKISDKGANQEIMKAFQLFDNDNTGKISYANLKRVAQELGETISEEELREMIQEADRDGDGEVNQEEFLRIMKKTCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQY4</accession>
    <name>A0AAV6UQY4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000294">
        <property type="protein sequence ID" value="KAG8186655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQY4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="161" mass="17989" checksum="A82F701AE62512E3" modified="2024-11-27" version="1">MDPTLIKVDGALVTDTATINCDLDFFSTIENAPDVIIDASLSIPKPESTFQDDIDDFFEALVSNNDSVEKQDNFVNENSSDLTVLANENLKLKKTIREFKLVNIKQESELANCEQNLAEKWIALESVKSELHTVKDKNQALETENIALKFNVTQLELVDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUI8</accession>
    <name>A0AAV6UUI8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_009871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000251">
        <property type="protein sequence ID" value="KAG8187992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUI8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF10">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="91"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8187992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="281" mass="31774" checksum="88F20DBDE120DD79" modified="2024-11-27" version="1">MGHKFVLQTDHKPLTAIFGEKRGIPPIAAARMQRWAIILSAYQYEIQFVKGNSISHADALSRIPLPETVEEVSCFSMCDEFNHFIYFFSAVESAPLTAKEIAVATQEDPVLRQVLHFFYTSLSMVGRNYSKWVEVFLMNKTTAEHTITKLRTLFSSYGLPELVVSDNGPQFACEEFSDFLKRNGIRQALIPPYHPASNGAAEKTVQTKYATRNHQEIPSRDVLGQEAAHPAVPDSAQHGGKCRNHGPEAASLFHSRRDSLRQKRPRRKGEMLPWKNHPPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWF9</accession>
    <name>A0AAV6UWF9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Frizzled-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_026769</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000234">
        <property type="protein sequence ID" value="KAG8188665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWF9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15035">
        <property type="entry name" value="7tmF_FZD5_FZD8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07456">
        <property type="entry name" value="CRD_FZ5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000262">
        <property type="entry name" value="Frizzled 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000004">
        <property type="entry name" value="Frizzled class receptor 8a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF126">
        <property type="entry name" value="FRIZZLED-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044023371" description="Frizzled-5" evidence="17">
        <location>
            <begin position="21"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="18">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="19">
        <location>
            <begin position="249"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="143"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8188665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="67482" checksum="D3409C79AC4CF0E8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXZ1</accession>
    <name>A0AAV6UXZ1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">JTE90_019042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
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            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000218">
        <property type="protein sequence ID" value="KAG8189282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXZ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8589" checksum="3194B76C88B89ED1" modified="2024-11-27" version="1">MPPFEADFVLFLTNLQQPISAISTSSPKALHPNTKTPPEKLQVASLSSLQISLPRNPLLKQQRVLLRGKGKQTTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAV6UZ05_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000215">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="130" mass="14704" checksum="A6DE472F60D1D688" modified="2024-11-27" version="1">MFTTAKSARISDADSQAPRPGQVCVRHARPGLSGVTTRRILGPGGVEAPPHPPTCRRDRLLSFPCRPCPKTDPQNTERRVTFVSWVVANDLTRRVEYEFGFSWEYDTHFNNILRTKTGLEFLTAEKDCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0V3</accession>
    <name>A0AAV6V0V3_9ARAC</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
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        <lineage>
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            <taxon>Araneomorphae</taxon>
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    <reference evidence="1 2" key="1">
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            <authorList>
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                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000217">
        <property type="protein sequence ID" value="KAG8189384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0V3"/>
    <dbReference type="Proteomes" id="UP000827092">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9557" checksum="904206CE20A2D66D" modified="2024-11-27" version="1">MISGHNHPMHHKASFLTVSPTSLAEKLFMGSNDFSVAFSGTESGEMYSCHRPFISMIFNEKEKVMNRVDSIQNRLDFYLSPLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2G8</accession>
    <name>A0AAV6V2G8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_005820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000174">
        <property type="protein sequence ID" value="KAG8190784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051744">
        <property type="entry name" value="AP2_assoc_SerThr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47907:SF5">
        <property type="entry name" value="AP2 ASSOCIATED KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47907">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8190784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1352" mass="146135" checksum="1AD8F06B4B1C3E2E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2V4</accession>
    <name>A0AAV6V2V4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_011919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000191">
        <property type="protein sequence ID" value="KAG8190196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2V4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP9-like helix-turn-helix" evidence="2">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="3">
        <location>
            <begin position="116"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8190196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="245" mass="27704" checksum="7C4E091958964A33" modified="2024-11-27" version="1">MCDIKRSEFFPQTTKHKKPPKERRPANVSISSVEASGMEKNISAVEELAGVELDHDYAISGSPRKLKRKYEQIVDEKNKRIDLMKLKAYDYIRKSLSLCLPHPCTVRRWYNVIDGRPGFTAEALSALKYRLDVTPYKVYFAIMFDEMAIKKHLSWDGNNFFLYSTLGADICSEESREAKEALVFMAIGLNVSWAISIAYFLVDGTSAQDKANPITQAINILHDLGGTVMSPALICNSRICLQQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3X5</accession>
    <name>A0AAV6V3X5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000177">
        <property type="protein sequence ID" value="KAG8190673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3X5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="221" mass="24845" checksum="5A3F27222B6D0374" modified="2024-11-27" version="1">MKGYLPHLARALQFCSCPRFCKHYVCCWSRLQCWDVGDMPGRFFGLLATFAALAVIASGDGLRRTDRSISAHLLHLGQCRRQFTFLASAALGVFLTRVLKESPLTPLPLPPLESSLRWNLVTVPAHLAGPFYNWITRHPAGQTVHLNQGFGGLVEAGGLFRSENKISSTHSHWKNNIISQAIHMRYSRDSVANAFQRTLKPLKFILPHAMGIRRWLLRLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3X9</accession>
    <name>A0AAV6V3X9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000186">
        <property type="protein sequence ID" value="KAG8190321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3X9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="9758" checksum="1ACE8DD677AD3328" modified="2024-11-27" version="1">MLIAPKTRPHRNASCTTRVQQGHLSSSRYKGVMESHSGASQHKKSQGPPCLQTQLTFGCEKHLQGVLSVVLYGFYFSLGNVLRDIEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V748</accession>
    <name>A0AAV6V748_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_008817</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000153">
        <property type="protein sequence ID" value="KAG8191754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000742">
        <property type="entry name" value="NFX1-type zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="9">
        <location>
            <begin position="1973"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8191754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2059" mass="237157" checksum="694E5D523BB031D7" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7M6</accession>
    <name>A0AAV6V7M6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase</fullName>
            <ecNumber evidence="7">3.5.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartylglucosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glycosylasparaginase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_007715</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15947"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58080"/>
            <dbReference type="EC" id="3.5.1.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.26" evidence="7"/>
    <dbReference type="EMBL" id="JAFNEN010000149">
        <property type="protein sequence ID" value="KAG8191915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7M6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003948">
        <property type="term" value="F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04513">
        <property type="entry name" value="Glycosylasparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000003">
        <property type="entry name" value="N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF6">
        <property type="entry name" value="N(4)-(BETA-N-ACETYLGLUCOSAMINYL)-L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="214"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="237"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="13">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8191915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="323" mass="34862" checksum="53C4426EF63307C4" modified="2024-11-27" version="1">MSDSHSLPFVINTWAFTNGTAKAWDVVYKAGRSALDAVEAGCSQCEIEQCDHTVGYGGSPDENGETTLDAMIMDGVTHDVGGVAALRRVKSAISVARKVLEHTEHSLLVGDQATQFALRLGFKEENLSTEFSLDMWKKWKTNNCQPNFWKNVSPDPKATCGPYKLQFDTQEHHKFKSKFGKDNHDTIGMIVIDSEGKIAGGTSSNGAKFKIPGRVGDSPIPGSGVYVDQDVGGAAATGDGDVMMRFVPSYNTVENMRHGMSPTDAAKDSIKRIAAKYPNFSGAIVATTINGVYGAACHGMEKFPFSIANRKFGNVTVETVYCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7X6</accession>
    <name>A0AAV6V7X6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000138">
        <property type="protein sequence ID" value="KAG8192577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7X6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="302" mass="35319" checksum="99B8A97ED792AC33" modified="2024-11-27" version="1">MSKPIDVLLLTLQKILKHYQLVGWRNEKLTTHIREDISNFSRKYCENMDPDVVDYLEISMHVGDHILCFGEKGNHDDPTEVSATNNETDTGSDELFIDFSKIYRGNPEHSLETISQSKSNEKDSFSVDNSASSQISVTKDPTDFERANLLIDFSKATHGVSIDLQKTVKNKSDESDSFISHSESESKDDEDMELHKIKRKKGVRNEHKWRRNVRQNNRLLGKKYVPTKNVAIEEKSIKPPCPDKCRLKCNQRFTEEQRLKIYSKYWHLKSWDLKKEFVCSCIQTFPVGTHRFWYKLDCCWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8P4</accession>
    <name>A0AAV6V8P4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PTTG1IP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_017988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000139">
        <property type="protein sequence ID" value="KAG8192458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8P4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052304">
        <property type="entry name" value="PTTG1IP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15191:SF3">
        <property type="entry name" value="PITUITARY TUMOR-TRANSFORMING GENE PROTEIN-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15191">
        <property type="entry name" value="PROTEIN CBG20567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043955750" description="PTTG1IP" evidence="2">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8192458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21288" checksum="177A9065867B21F6" modified="2024-11-27" version="1">MYTVLTILALTLSNVVCQNESETTSSTQIDTTTPATLSTSEKPKNISCPTHNGDCKACVKNSECYYCMTDEKCYFKLTDILTREKCEFKKIQYLTCKVNLQYLIIGISVVAGIALLVILIFCCCCCCKKKGIKLSKSDLKWQRQREERKQIAAEKRKERAERTEEIRKKYGLVKDSNPYQKFDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8T1</accession>
    <name>A0AAV6V8T1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000128">
        <property type="protein sequence ID" value="KAG8193155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8T1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="157" mass="18565" checksum="CA8BD0BB14B033BE" modified="2024-11-27" version="1">MASDNRYHKNCKAIANDFSSSKEFKEKTIPANPFVQTTKKLFDVGDDERLQNYQEAYLEKWKGRIAKEATAADEEYYKFTLDPPSEDFMRVPQKGESFYYIPEQHLQWAWTGRRLQRKSIHELEDQLKYCGRNKSEPRASSDSKYAFDNGIYKILIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V900</accession>
    <name>A0AAV6V900_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Integrin alpha-PS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_002163</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000141">
        <property type="protein sequence ID" value="KAG8192343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V900"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF122">
        <property type="entry name" value="INTEGRIN ALPHA-PS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="942"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="228"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="288"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="355"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="14">
        <location>
            <begin position="403"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="15">
        <location>
            <begin position="569"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="16">
        <location>
            <begin position="716"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8192343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="989" mass="109890" checksum="CB903970130E7DCD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V949</accession>
    <name>A0AAV6V949_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000140">
        <property type="protein sequence ID" value="KAG8192388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V949"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11369" checksum="DED0DD7AAD0C6A58" modified="2024-11-27" version="1">MLNHIRNCNHNRDANKAINPIQLTTKDVADDTLLPGVGGGVDGVDDGPGLADHRYVVWVSLLEWLIWVRWKVVRKEGGGLDCPNRTINPIKLTTKDVADETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9B8</accession>
    <name>A0AAV6V9B8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial cardiolipin hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial phospholipase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_009786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9B8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051406">
        <property type="entry name" value="PLD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856">
        <property type="entry name" value="CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856:SF1">
        <property type="entry name" value="MITOCHONDRIAL CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8192767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="161" mass="18218" checksum="267932D6A3F67ED0" modified="2024-11-27" version="1">METFFGKRKLSTDANLLGQTGLSADTENHSRLPMFDQFPEVTDLNVYPCFLPGNHCIYHIENFINYAKKSIIIQAYRFSSVAIGEALIDCVKRRVIVKILIDKGAFLNNSYLKTLEGCGVEIQVDRHSGKAHNKIIIIDDDYVITGSYNFKMKVITVILIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBD6</accession>
    <name>A0AAV6VBD6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000124">
        <property type="protein sequence ID" value="KAG8193373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBD6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="9857" checksum="E3C61EA8DDD59FFB" modified="2024-11-27" version="1">MSNWKQCPILKGVQPSRSKLGSCSTSQVHESAMDLSIEDEEQELQKEPIPSSAQTFEPRSKKKEETPNSIMAKAAAALESIINVPSGDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VD28</accession>
    <name>A0AAV6VD28_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000106">
        <property type="protein sequence ID" value="KAG8194256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VD28"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="196" mass="21864" checksum="FF583F51EA3BFB58" modified="2024-11-27" version="1">MRIKYRLLKTTPATGRDDCFVCGVNLGIYLQKRKLSGGTQQTLYKMKTLLQTIFRVLLMIGVVLTDPPAPRQTLTSSSALFSPLAPATVLKEGCPRREDIHPCECLEIPKESSESGEPSAGLETVAFCKTIRNTQVLQNAMKGMQGHIIDFMVLDSCKLPPFPNGLFFNVGIKWMEILNSTVQLKQNFFECASNCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDI8</accession>
    <name>A0AAV6VDI8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_013665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000112">
        <property type="protein sequence ID" value="KAG8193970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDI8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043697824" evidence="2">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="135" mass="15822" checksum="ABD64706BFB0B398" modified="2024-11-27" version="1">MKFTLLIVVGLCLIVSLEAKREREDSERQRGDRGRDDGQFSRQRGRRNNRMKVPFPMFPSCNDFNEEYMMKMRELRRLNKIGPNVCKDQDRTVCHQKDRDTVRCALTDEIPEECLQEINDFLEAASCTTTTETTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFX6</accession>
    <name>A0AAV6VFX6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_002191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000084">
        <property type="protein sequence ID" value="KAG8195565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFX6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045583">
        <property type="entry name" value="KPBA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF8">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19292">
        <property type="entry name" value="KPBB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 6" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH15-like" evidence="8">
        <location>
            <begin position="54"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphorylase b kinase regulatory subunit alpha/beta C-terminal" evidence="9">
        <location>
            <begin position="948"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8195565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1116" mass="127604" checksum="1138F6CF5BE935C1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGM1</accession>
    <name>A0AAV6VGM1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_017284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000098">
        <property type="protein sequence ID" value="KAG8194851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGM1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="694"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8194851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="849" mass="97359" checksum="2A754FEB5B94325B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIX7</accession>
    <name>A0AAV6VIX7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Molybdate-anion transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Molybdate transporter 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_014485</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000064">
        <property type="protein sequence ID" value="KAG8196752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIX7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17487">
        <property type="entry name" value="MFS_MFSD5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008509">
        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516:SF1">
        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516">
        <property type="entry name" value="SAM (S-ADENOSYL METHIONINE) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05631">
        <property type="entry name" value="MFS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8196752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="461" mass="51812" checksum="426CB8336A0F0C28" modified="2024-11-27" version="1">MILPLTNSTEEVSVIYDPKSWFTYFIYVFLLISISVCTALQLMVKASKTNLPVTNNLHFNIFQRKYFIVYFLALFGDWLQGPYIYKLYSHYGFTNFQIAVLYVVGFSASVLFGTGTGALADRFGRKRMCMMFCITYSLCCFMKLFPNYNILLLGRLLGGISTSLLFSVFESWYVYEHIQNYDFPKEWIAITFSKATFWNGVLAIVAGVIANFTSDVLMFGPVSPFILAIPCFILSCVIMSKIWRENYGKTQTSSKNICIEGLQVILNKPLILMLGVVQSLFESVMYVFVFLWTPILDSVHPPLGIVFSVFMVCIMIGSSFYQLGLYRQVEPHSLLQLAVALAAVSQIGCAIATSSPETNILIASGSFFLLEVAIGIYFPAIGYIKSECIPESHRANIMNWFRVPLNIITCIILLSLHGERDSGGNSVIFLICAAMMMCGCFITMKIGSILPHVRMTLNQIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VK15</accession>
    <name>A0AAV6VK15_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_011318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000058">
        <property type="protein sequence ID" value="KAG8197157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VK15"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000001">
        <property type="entry name" value="Cryptochrome 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF30">
        <property type="entry name" value="CRYPTOCHROME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="292"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="390"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8197157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="539" mass="62398" checksum="8358819FB2C432EA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VK25</accession>
    <name>A0AAV6VK25_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription elongation regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_023803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000073">
        <property type="protein sequence ID" value="KAG8196247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VK25"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000005">
        <property type="entry name" value="Transcription elongation regulator 1 (CA150)"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000006">
        <property type="entry name" value="Transcription elongation regulator 1 (CA150)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000008">
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    </dbReference>
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        <property type="entry name" value="Transcription elongation regulator 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR057565">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
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    </dbReference>
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        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23517">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="4"/>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="625"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="693"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="853"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="912"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="977"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8196247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="998" mass="113919" checksum="7D647262CE267117" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLW3</accession>
    <name>A0AAV6VLW3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_001616</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLW3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902742">
        <property type="term" value="P:apoptotic process involved in development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070782">
        <property type="term" value="P:phosphatidylserine exposure on apoptotic cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF10">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8197692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="458" mass="52454" checksum="A8915A49D51AD942" modified="2024-11-27" version="1">MLNEVELMEELPYYRTLQKPPQHHHQPPISTAPHYPTAPRGGYRSTLDNRIAYDDETAIAIIAPDIRMPQQLHHHNSPLSIESPSRYTPPGCADVLASLLALALDVGTDALACYVLFAEGRTLWAALAAAFVLLASAVCNILSLWWYIRNQRTSVYAIAGTWKWVVRIIFHVLCMGLLYRYLQLLFNCLCRDHLEDREHRSVMEARKRRNAILHMTIKEDRQTATLGLLHSFLESAPQLVLQLYTLAHRTEEDRQLVVIVQGACAASSLLQLAWSITCYNCTLHRTQPARKKPNAAGKTLQFLWHLCTIGSRACTLALFTKEYHFWLFPFCIGHWGVMTIWVMHQQTRLCASGSDNRQCREYACNMVVGVAYVIYYLNVKAEPTRYKYSAYYAIVFAENCALMTLWFLRNDPGVWYHIPALVAVFSSFASGIVFMLFYYGFCHRTLKQTNEKRAARCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMB9</accession>
    <name>A0AAV6VMB9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000049">
        <property type="protein sequence ID" value="KAG8197835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMB9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="10037" checksum="819B7D08998392F5" modified="2024-11-27" version="1">MQWTSDPQANFTTNENGEPWLPVNPNYITRNVDTQTQETQMFRKLSDLKQSEESLLPPLETIPTIVHSVAIGFSSPFGGPGPHKYEWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMD3</accession>
    <name>A0AAV6VMD3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000049">
        <property type="protein sequence ID" value="KAG8197850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMD3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11087" checksum="FD8E3FC0A1464930" modified="2024-11-27" version="1">MATACTSILWGHSSRSNRTYIFFSYQVVLNPFGPFLISPNSGTSTTKHTCHPILALDTCCPPRVIPVCSLRVISVGVPLINNGCFCPPHPINKGSTPSERGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VN59</accession>
    <name>A0AAV6VN59_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_020927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LplA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000044">
        <property type="protein sequence ID" value="KAG8198104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VN59"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000045">
        <property type="entry name" value="lipoyltransferase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="62"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8198104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="319" mass="36733" checksum="050C6459E003F234" modified="2024-11-27" version="1">MLSFYISRNFRTFSGISQKQAADTILDTLHNARNSIIISQSHDIYENLAFEDWLYKNCDLDDKDSSFLLIWYNGPSVVIGRFQNPWIECSVDFCNANGISIVRRNSGGGTVYHDFGNLNFSFFKPPNNYNRKKNLEFLCESIRRRWHINLRVSERDDILCNEQYKISGTASKIGRTNTYHHCTILVKADELKLRKALHRELESITSKATSSTRAKVINLNSISADIDTLKVVKAVTDYYKLIHEVEDKNLLCLRPNELICPGYESIKENLQSWKWLFGGTPEFKVTRSFKMSSLNSSQTKSNPSCEIVLTVNKENYTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNN8</accession>
    <name>A0AAV6VNN8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_001577</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNN8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000002">
        <property type="entry name" value="Sodium/potassium/calcium exchanger 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF72">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER NCKX30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="268"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8197648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="434" mass="46805" checksum="F23D5201BEA2375B" modified="2024-11-27" version="1">MKRRASTPILHAGSKFRHGLLQLMIHSIDPLHDGKLDEKASQLHAIASLRVLLDAAKANGGYPSGTTGASAQHPIPQGGCCSSCAQCPQCATCPTCQRPMINKTPLTDTPMTTFGESGQLYQHPAASGPRRQVDPLISVQNLQSSAVISTLANGTVNEHQDAETSFSSRSPVAGPNSPGISTIMSDSPAVTYIQPGLTPTSTGGESSHQDIAGSVPKPPEEIEVDEPLDISWPKENKKRVSYVLMAPIIFPLWLTLPDVRRDEKKKWFFITFLGSILWIAIFSYLMVWWATVVGQTIGIPNEVMGLTFLAAGTSIPDLITSVLVARKGFGDMAVSSSIGSNIFDVTVGLPMPWLLSALIFGPVKVSSSGMACSIVILFIMLLFVIISIACFKWRMNMGLALVMFLLYFAFVAMSLLLEYNIIDCAMLMSYVGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPB7</accession>
    <name>A0AAV6VPB7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_001646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPB7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035253">
        <property type="term" value="C:ciliary rootlet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097542">
        <property type="term" value="C:ciliary tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033192">
        <property type="entry name" value="ODAD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8197724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="543" mass="64007" checksum="02D86A0E1FF6D71F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VR79</accession>
    <name>A0AAV6VR79_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_021513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VR79"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="181"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8198256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="565" mass="63456" checksum="9F26DCD8AF0F22DC" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRQ2</accession>
    <name>A0AAV6VRQ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Gamma-butyrobetaine dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_015289</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000042">
        <property type="protein sequence ID" value="KAG8198191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRQ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF55">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="11">
        <location>
            <begin position="151"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="10">
        <location>
            <begin position="262"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8198191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="61124" checksum="3C354281BD3D5E86" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS89</accession>
    <name>A0AAV6VS89_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_009361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VS89"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8199515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="124" mass="14452" checksum="9FEB7D0AC2F0D9BC" modified="2024-11-27" version="1">MAKIKSEKKAKSALSEVVTREYTIHLHKRLHGIGFKRKAPRAIKEIRKFAEKQMGTPDVRVDTRLNKFIWSKGVRNVPFRVRVQLSRRRNDDEDSIHKLYTLVTHVPVTTFKGLQTENVDVSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSZ9</accession>
    <name>A0AAV6VSZ9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-like protein family member 10B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSZ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052661">
        <property type="entry name" value="Ras-like_GTPase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46350:SF2">
        <property type="entry name" value="RAS LIKE FAMILY 10 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46350">
        <property type="entry name" value="RAS LIKE FAMILY 10 MEMBER B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27506" checksum="36AD4B0303D52BAD" modified="2024-11-27" version="1">MTAKHLNIRCGIGSHHFLQIHKFTKAISSAMEMVKVVILGAAGVGKTSLIRQFVESEFIEDYTPTDTKAVYTPTLVFNEHIYSMRVVDLPVIPYFPSNSANEWQDYRDYGLRSASAYILVFDLNDLETFQYVKSIRDQICDTRDMHSVPLFIVGNKQDLLRGREHREVAGLVKKHWKCGYVECSARHNWHVVLLFKELVRVLDYADYGQKLSSYSSPRFEGLHAHRDRRGDSVVKCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT19</accession>
    <name>A0AAV6VT19_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000023">
        <property type="protein sequence ID" value="KAG8199844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT19"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="9017" checksum="9E9BF40C76FBEA96" modified="2024-11-27" version="1">MPASFYVPAFDTRLVLYIFILRGASQPHRSCQPRSPPRMPQRPQRPGPTPISNTRSYEQSHWYMFMLFEEISGRTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUU6</accession>
    <name>A0AAV6VUU6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dual specificity protein phosphatase 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_009327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUU6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008579">
        <property type="term" value="F:JUN kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="80"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8199479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25060" checksum="0D2BA0BA69D001C9" modified="2024-11-27" version="1">MFSRIWFHLRTTVSVLNGMAHSDLFREVRGFKNNDLRSVSTNLTAGDGQKFVETLMNGGYNIARSGHATGYVVDTKADITVSLIMDGLILGSQDVAAEISILDDFNVTHILNVGYRIPNYFESKFIYKNVEILDDPSSNIAIFFEGCFEFIDDGRQEGCVLVHCNAGVSRAPTIVIAYLMNRKKMTLKEALALVKSVRASIRPNDGFMKILEEYEKELAKRDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUX6</accession>
    <name>A0AAV6VUX6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUX6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="95" mass="10649" checksum="3AF9E6A87739DEAF" modified="2024-11-27" version="1">MSALTPQEGAVYPTSPSITRLPYHRILRGSGRLIRLALSATAELSIQSLPASFIFRIRDPKRQWKINSSSSFSVNRSAPPFPLRWSKIPEFCFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUY8</accession>
    <name>A0AAV6VUY8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_003694</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000029">
        <property type="protein sequence ID" value="KAG8199271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUY8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8199271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="231" mass="26701" checksum="5A7303A930D0CB92" modified="2024-11-27" version="1">MNFHKFCLFCRGHPTTEVITGTMDERLHFPEEPYTCDVCKKTYQSKLQLAKHMLSHPGEEKPFTCKTCQESFRTKNALKKHRPIHGGMRQFVCEVCSKAFKYNLILIHTGGKALFFQRHPTAEVLTGTMDERLHFPEEPYTCDVCKKTYQSKLQLAKHMLSHPGEEKPFTCESCQESFRTKIALKKHRPIHGGMSQFVCEVCNKVFKHNLTLNLKTLPLDSKVKTISIQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VV65</accession>
    <name>A0AAV6VV65_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_000582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026202">
        <property type="entry name" value="GOLGB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031632">
        <property type="entry name" value="SVIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18887">
        <property type="entry name" value="GOLGI-ASSOCIATED PROTEIN GCP360-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18887:SF5">
        <property type="entry name" value="GOLGIN SUBFAMILY B MEMBER 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15811">
        <property type="entry name" value="SVIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2773"/>
            <end position="2843"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="118"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="276"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="568"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="758"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1121"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1334"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1645"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1740"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2087"/>
            <end position="2114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2157"/>
            <end position="2384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2502"/>
            <end position="2561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2648"/>
            <end position="2689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2783"/>
            <end position="2836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8200505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2843" mass="331314" checksum="E2E6F92EFFB33003" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VW61</accession>
    <name>A0AAV6VW61_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VW61"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257:SF974">
        <property type="entry name" value="RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="217" mass="25024" checksum="5420272410F990C1" modified="2024-11-27" version="1">MRKGPTLFEYLHLKRHKLPFHSKHNIARQIAQGMGYLHAKDIVHKKLNSKNIILECRVKVCIMDHSMSDKQLDRNDYGCIPRGHLSYISPELMSSLQIEPPRIFATQSYTKESDTFAFGSLLFELLCERFPFHDLPPHSLIWQISSGRMPSLHNFRFINGLKALIKRCWSLNPGQRPAFCEIGQILQENVSHHRRHSCSEPDLLHITGQASTRGLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYH4</accession>
    <name>A0AAV6VYH4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYH4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7266" checksum="75AA031DDF78C3C9" modified="2024-11-27" version="1">MSISLRSNLKSMGLIFISVAISDSSVPLKVSHTTPCLLLPYSEEYRVEGAVEVCVLTERSIEELSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYJ5</accession>
    <name>A0AAV6VYJ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Synapsin pre-ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_028778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000008">
        <property type="protein sequence ID" value="KAG8201110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYJ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007269">
        <property type="term" value="P:neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001359">
        <property type="entry name" value="Synapsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019736">
        <property type="entry name" value="Synapsin_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020897">
        <property type="entry name" value="Synapsin_pre-ATP-grasp_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10841">
        <property type="entry name" value="SYNAPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10841:SF17">
        <property type="entry name" value="SYNAPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02078">
        <property type="entry name" value="Synapsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10581">
        <property type="entry name" value="Synapsin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01368">
        <property type="entry name" value="SYNAPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Synapsin pre-ATP-grasp" evidence="2">
        <location>
            <begin position="189"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8201110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="283" mass="31991" checksum="711C41E464827189" modified="2024-11-27" version="1">MRHISTIINCNQETASLSSDSYSFNYLSQITEKRLETFPLKSFRTIIFPPEITTKSPHQSVNGTSSDDKQRCLKQFSKTDPRTTPGAKISFSSFKQSFASTTSYLRRRFSSGDLSGELDEEGQRIEGQEGEDGRVEVQQSQEPSDVAGGRGRGTTISAPTSPSKNLPAFQQRANSVTAGSVMKGAPSAKDKHKTLLVIDDQHTDWSKYFRGKRIHGDWDIRMEQAEFKDINLAVNSDSDKPWVFSQLLHMQRRLGKENFPLIEQSYFPNHKEMVSTQLHNYMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W0H0</accession>
    <name>A0AAV6W0H0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000006">
        <property type="protein sequence ID" value="KAG8201294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W0H0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="120" mass="13594" checksum="D2F4E209FA717FAC" modified="2024-11-27" version="1">MRESSHESPGDYVRDQAPQEEQQECPRPSERRPNQVEPEQAAPGAAECRARHFGEPAPLRAERALQARQALHSATQRQLSAHKELFPGIPLGSDDSLKTEGHQKRNEASGENQRRQYFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W0I9</accession>
    <name>A0AAV6W0I9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_016790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000006">
        <property type="protein sequence ID" value="KAG8201309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W0I9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043585824" description="Peptidase S1 domain-containing protein" evidence="7">
        <location>
            <begin position="34"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="414"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8201309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="648" mass="72642" checksum="00C178372F6BFD74" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W325</accession>
    <name>A0AAV6W325_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W325"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="174" mass="20224" checksum="09FED6D231B25FC0" modified="2024-11-27" version="1">MTGGINEDHFLYLRPWRCQDSNEAWHDKDTQHYFYGAGVVEIQFKRGHFYLIVHLKPTLSRDLKIPHLDQSSRVNSTQAKSILAHPSPLQVRFILEQAPDVIPTPGIGDLAQLIYYGINREINGQLIQYVASCNLLQMRQKWCRCPPAQCEGHLVWMTDVRRRIHVPKPRGRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W3R7</accession>
    <name>A0AAV6W3R7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W3R7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8202052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="117" mass="12914" checksum="5E1854BD655232E2" modified="2024-11-27" version="1">MREAGNCCYFCSAHSVPGAYSEPVSYNSAEQCCVLWSVRTGRMAVISRPRMVNLLSSGLEFERASQGITTQVSPITGLVLGNILFRGQFRVDMKANSKKENNKKRIIAVKLNPSVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCD4</accession>
    <name>A0AAV6TCD4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007750">
        <property type="protein sequence ID" value="KAG8155630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCD4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8155630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="31" mass="3291" checksum="CA4D95F54825B463" modified="2024-11-27" version="1" fragment="single">EMGSIVSFAFPPPHEPLRPAPRAMVSLTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCU0</accession>
    <name>A0AAV6TCU0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006972">
        <property type="protein sequence ID" value="KAG8155713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCU0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8604" checksum="60691E281638E56B" modified="2024-11-27" version="1">MRSSGKLLLDEKPPRCQRREMKRGDNKKNGCHHLERNVGEMFFFRLPEESNGHFSGDRVSRGHRPREADGAAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEG8</accession>
    <name>A0AAV6TEG8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006259">
        <property type="protein sequence ID" value="KAG8156168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEG8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8156168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="109" mass="12655" checksum="D8C299E999912C20" modified="2024-11-27" version="1">MTYADVRKNLQMSPHLFTQQRPTTHHLTCHVKHLTFYLGGKFTQDYLKEAWHEPRIVCLDSATHNLLLGLMPNVTLLDGQLRQNNSLDLSLRAARLLNTKLGLEPYWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFK0</accession>
    <name>A0AAV6TFK0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005294">
        <property type="protein sequence ID" value="KAG8170522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFK0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="143" mass="15353" checksum="C2A10D474939A883" modified="2024-11-27" version="1">MVVTVTGNQGSIPEREPEKRLPHPRKAAGAQITHSRNGEVVTKNNDTGTLLRPRNWNEYTLNPLAIINWRASQVPAAAPAIRLCSSNDTPGSFRETKAFGFRGSMVAKLKLKGIDGGSPPVMGLAVQFDSNAANPTRPGHGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGH4</accession>
    <name>A0AAV6TGH4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005052">
        <property type="protein sequence ID" value="KAG8170676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGH4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="200" mass="22394" checksum="11A011B5549B42CB" modified="2024-11-27" version="1">MRKGSDFGNERLLAQNHRLVSVEVVTRIIWLIAGLVRRRILQGLPYKLSMVGMRYLCRNGDGGFRVRFRERELRNATTSKEGSRGRKIPTQKGGGMTKNKIGIFETRNWMGTLNLLRLSIGGSQGQQPRNTLAPIAQRSGCVPQKTRRQLRKPKLWVGGSMVAKLKLKGIEEGHHSNGVPGQLTQRSDPTSQEHGEDGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGS3</accession>
    <name>A0AAV6TGS3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004658">
        <property type="protein sequence ID" value="KAG8170936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGS3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="124" mass="13758" checksum="303F54D7E052916F" modified="2024-11-27" version="1">MGTESMRRPYPEETSEEPLLDGSMSYAARPSSDDRFARQEKPLRTFPQISSGSSVRGISSPSFGFPKSVRFNTPPLPQVETRRVSGAPRPRGNGIPKRAGPPAALLSFRRRAYSRKPLDSPHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THR9</accession>
    <name>A0AAV6THR9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004285">
        <property type="protein sequence ID" value="KAG8171223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THR9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="8935" checksum="1AC99298329847D2" modified="2024-11-27" version="1">MAPSVPLNHYLCPETHKSNRGLSLFHAPVFVIVTACLCALLIYQSKRCRSTETTGEIIKGNRLLFQKGLVTAVRRHRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJ03</accession>
    <name>A0AAV6TJ03_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003785">
        <property type="protein sequence ID" value="KAG8171588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJ03"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="103"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="278" mass="31133" checksum="3405EA5153CA79A7" modified="2024-11-27" version="1">MCMMMSQGAKKHVFCRISVRTKRKFIEKRMLAVLETSAFHSMIEDSEETDSDESMIENDILATLTTKCLYKDANVAELSSVVLTPEQGKLIEESTRDQSMSQEWKEQRKGRITASYFGRVCKVKTGVDRLVLELLGESAAPEGLPALQWGRKKENDALISFEKVEGVNHADLKITRSGLYVSLDKPYLGASPDGFANCSCCSPAVLEIKCPYSIRNNRIGDSCGKSNFFLDENKKLKRNHNYYYQVQGLMHITDGGITFAKGSLSPAFGKQHPEEAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJU8</accession>
    <name>A0AAV6TJU8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003144">
        <property type="protein sequence ID" value="KAG8172082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJU8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="9708" checksum="0A9B53B024CB5EAD" modified="2024-11-27" version="1">MAVSSRGAQISWNHCKASPKDVPWEWTAEHEEAYKASKGLLTTDDLLVHYDEKLPLILTSDASSYGLGSVLSHLLPNGKEAPGPIIHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKV1</accession>
    <name>A0AAV6TKV1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011964</name>
        <name evidence="2" type="ORF">JTE90_015618</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003239">
        <property type="protein sequence ID" value="KAG8172025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010000261">
        <property type="protein sequence ID" value="KAG8187748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKV1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="123" mass="13875" checksum="9FF747C6844D414C" modified="2024-11-27" version="1">MQKIKPVPRFHMDSEEEDESEFAINWYLQQTRGAPAVVRTPSPAVGVQNDSLSDSQSTEIYDVETITTSTPKINIETPASVPHPEARYNLRNRAISANLPTVRNSEQPILVKWLDTLTEALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKV3</accession>
    <name>A0AAV6TKV3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002987">
        <property type="protein sequence ID" value="KAG8172196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKV3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46703">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46703:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="9800" checksum="5A96B195363D3F74" modified="2024-11-27" version="1">MLVFCLAADRKGMGLIFPNPDTEIGPSGPSAVTQPNSETSTEDPGKSYLFFVRVRVPGIGSSGDRDAVLVKAPRLLRCPVRLCCPLKIRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLN9</accession>
    <name>A0AAV6TLN9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubinuclein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002455">
        <property type="protein sequence ID" value="KAG8172687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLN9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="13645" checksum="BB1FA7584B294DE2" modified="2024-11-27" version="1">MLLKAPSVPKPPFNSAPVLPKAPSVSKPAFNSAPMLLKAPSAPKPHCKSNPVLPKATSVPKPPFNSAPMLSKAPSAPTPPSNIHISPTNCSPVLDKSPSVSNSSSNFPVLAKTSSAPTLPSNLHVYPTMLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMB9</accession>
    <name>A0AAV6TMB9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002395">
        <property type="protein sequence ID" value="KAG8172773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMB9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="8676" checksum="005AC155F5740C66" modified="2024-11-27" version="1">MVIDKLSMCWKNCVSIVKLCCTRMLCPISRIQQAGATGQSLCYPLLTSPVCWRVVINVPDTQDTFNVVTLLTVEISGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMV8</accession>
    <name>A0AAV6TMV8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002223">
        <property type="protein sequence ID" value="KAG8172938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMV8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="469" mass="53976" checksum="0A2199EDF980A937" modified="2024-11-27" version="1">MCLSSKYPDAVPVEDITSVTVVDALLQIFSRMGFPKVLQLDQGSSFTSALSTTFLEKFGIKVVHSSVYHPQKTVTHESTGFTPAELVHGKNLRTPLTLLYEKWLDVEETEGEPVTEYVFSLINRMKRCQELAISKMEECQQKNKTWYDKRAVKREFRIGDLVLIFATFKSNKLSPHWTGPGTILRKLSETNYVVQLPGEKATTKVYHVNMLKSYYKRPEEINYLISDLEGENDEEQMEIPCVDSNPNILDLEEMFQDYGESSNMNEDQIAQMKNLIWKYMKCFSNVPGKTELVMHDIELSEEQSILSKPYRTSPRQNAILKTEIQKMLDLKIIEIGFSDCTSPMILVEAPGKDPRPCIDYRNLNKITKTKFFPLPNIEERIEIVSSAQYITVLELSKGYWQIPLTERAQRLAAFVTNFGTYKPLRMPFGLKNAPYEFSKMVYQLLEGCEEYAVPYLDDIAIFRTVSLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TN11</accession>
    <name>A0AAV6TN11_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_024055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002213">
        <property type="protein sequence ID" value="KAG8172946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TN11"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8172946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="152" mass="17525" checksum="2A4F93B1A812A0E1" modified="2024-11-27" version="1">MELTQAFPTTPTTFLKPPPAQPEPLPTYPKQPQHFSSLPQHNPSHSQLNLLIPSHPQHNPSHSQLIPSHPQQFPSRPCHVSSQQFTGGRKRKRINHMEVALENVMGKVVDRILAFEQEAEQNLQSHRNRMEQLMNEQNMQINDLLQEIKNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TN81</accession>
    <name>A0AAV6TN81_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_023106</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001971">
        <property type="protein sequence ID" value="KAG8173213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TN81"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043529404" description="Ig-like domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="118"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8173213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="237" mass="25702" checksum="521E96F7C5D21337" modified="2024-11-27" version="1">MILIHLLGCFLLCNNLSLIEAGDAPKVAPFSFPPALKNGERGSVACTIRSGDTPVDFLWKKDERDIKESDGIKIQSILDSSFLVISSVSSKSSGNYTCIVKNSFGSDQYTSILKVTAPPIWKVEPTDLHTQEGASEVIYCEASGVPQPEIKWIKGGEEQRGDVITTDPGSNLKVLPSGTLSFNKVESSMNGMYTCIADNNLGTVLSKSIFVSVREILFSFCSKRGFCNINGHILAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNY8</accession>
    <name>A0AAV6TNY8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001601">
        <property type="protein sequence ID" value="KAG8173614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNY8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19593" checksum="1543B65358BCBA11" modified="2024-11-27" version="1">MNSIARSLFWWPNLDLDIDDRVRTYNECIQNSHMLPKHLPPWPTAARVWSRIHIDYAGLVEGLMILVAQDAHSKWIVAMAVRNATTAVTIEKWRTPLALHGISPAEIMLGRQIRCRLDLVHSPSPNSNALEAPHNFFQNGEEVYIRNYASGERWVPGVINNPIGNIRLRSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPR7</accession>
    <name>A0AAV6TPR7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_019998</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001579">
        <property type="protein sequence ID" value="KAG8173639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPR7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039:SF28">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039">
        <property type="entry name" value="FIBRILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="267"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="316"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8173639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="523" mass="59108" checksum="12E95B1358E99433" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQ11</accession>
    <name>A0AAV6TQ11_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial cardiolipin hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial phospholipase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_016981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001554">
        <property type="protein sequence ID" value="KAG8173672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQ11"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051406">
        <property type="entry name" value="PLD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856">
        <property type="entry name" value="CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856:SF1">
        <property type="entry name" value="MITOCHONDRIAL CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8173672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="428" mass="49116" checksum="6B25C5312107F80F" modified="2024-11-27" version="1">MYSTFINCSFLQQNLTRQPRLSADTENHFRLPMTDQVTDVSGLNVYPCFLPDEHCIRHIKNRIDGAQISIIVQAYRFTSKSIGEALINCVKRGVTVKILIDKDGSPQKNNYLQNLANGGIEIQVDGQYGRAHNKVIIIDEDYVITGSYNFIDEEDYCDSDTVVFITDACVNKKFRDYYEFINSENQSFVNAETTLQQFDDNFFENYIIKKMPIDHRTPKQPSKQMAQYERLTENRSDFFGLPSWHNCCPVLNSSYNTSTDDEGNLKSEDTVYIDVCFPRFKNQDCIQLIAKYINNAEHSIFIQACSITHESILDALNAARAKIIDLKILIDTKAFDDKGEKVRNIISGGIEVRYDKTCPRGIAHSKTIIIDEDVVLTGSFNLTKSAQNFNQENLLQMKNLKLNGMFKEQFYKKWNAGSKVEFRKIEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TS00</accession>
    <name>A0AAV6TS00_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_015693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010001288">
        <property type="protein sequence ID" value="KAG8174211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TS00"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="3">
        <location>
            <begin position="358"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="754"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8174211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="943" mass="106262" checksum="055D4370DA1D7EE6" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TT77</accession>
    <name>A0AAV6TT77_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Baculoviridae p74 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_022623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001048">
        <property type="protein sequence ID" value="KAG8175200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TT77"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019058">
        <property type="term" value="P:viral life cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007663">
        <property type="entry name" value="Baculo_p74"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013613">
        <property type="entry name" value="Baculo_p74_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04583">
        <property type="entry name" value="Baculo_p74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08404">
        <property type="entry name" value="Baculo_p74_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Baculoviridae p74 N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8175200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="445" mass="50550" checksum="3B0352DA96F18405" modified="2024-11-27" version="1">MYMFHLYEQLYPDLFGHGSYSTRPATNDDYYIPTALAKSCLVVEEMTFDQEGCNSVGCFPFKHLGEPCTANDPVQFTQVGNTFSLSCQPICSSSDTTVDTEWLNDQCVMVNPYKKLVVMFPEKIFQRPTPHQYHSGLSWDHGQIKLNAPYCRAYGLDFNGRECTMTVGQRILEFFYGTTIFRNMRTANLRPIRPTIPPPAPTDMKAIQAAPVSLDNVVDVDSEQLAKDIATEMSADFGLDVGFHVVEKILKKKIPQLISKAAVRASVREAIKHAVIKNAAAITSKTFVTMGRMVSGISAVFSVFSVASLIVDLIDPQMYNYLLTGAMVDKINRKLDLSYFQREDNFNQVVTPEYVWEYVLPQPDQSAQYLYFADKVDEYLSALRPTEKVTTLPKAQFTIDKEILRFNWSLHLMVVGMLLMLTIMWVEWIHIWVCVLFFTIMLVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWU9</accession>
    <name>A0AAV6TWU9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_022446</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="JAFNEN010000900">
        <property type="protein sequence ID" value="KAG8176273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWU9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="29"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="177"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="447"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="20">
        <location>
            <begin position="552"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="659"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1024"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8176273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1121" mass="127183" checksum="217F90CD33E440B2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TX32</accession>
    <name>A0AAV6TX32_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Intraflagellar transport protein 22 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Rab-like protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_020160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000888">
        <property type="protein sequence ID" value="KAG8176374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TX32"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030990">
        <property type="term" value="C:intraciliary transport particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001100">
        <property type="entry name" value="intraflagellar transport protein 22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24073">
        <property type="entry name" value="DRAB5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8176374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="188" mass="21633" checksum="140E946950948313" modified="2024-11-27" version="1">MYKVKLLVIGPCECGKSVVSNFLADATESIPIEYYPTQGVRILEFESDSLTVGGRVGKAEVELWDCSGDTKFENCWPALMKDANGIIFVYNVDFSNIRKEMDMWYANFVQVQGLKDSQCLVCCHRKPNQHETRSSELSSLFSRIHWIQTNIEDNGNALRREFNAFLQRLLSNLSERREQEELSILNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXC3</accession>
    <name>A0AAV6TXC3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000936">
        <property type="protein sequence ID" value="KAG8175974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXC3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF25">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="403" mass="46931" checksum="92CBD7DDB4FD210A" modified="2024-11-27" version="1">MARIRNKKYKKNAAVRAGNIKKAAKKISGEMSFRKADAVYTVSKSTLNRHIRTLKKSEQPNLNFKYVSKIQSRKVFTNDEEEKLVDYMVQASKYHYGLTINDARTLAYEYASANKKNFPLNWEQEQKAGKEWYIGFKRHSKVFSLRKPEATSLSRATSFTRDNVNKFYDNLESILKREKFTPSEIYNLDESGITTVHVPPKVNAGKGIKQKGVYVEGGVKFIEIESQLRTDRDLSSFSQEDHHVGKTPLYDIRSTSFGLVSKFPLDVMHLVDLGVVRKLLMYWIRKGEKTNINSTRISQKQVDAISAKLIAFAETMPSEFSRKPRSLKDIDRWKATEFRQFVLYLGPVVLQRVLPREASYAFFMPTHCHLYIIASSFLFRRGVYFIRRTHFEDFCRRHEIDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXJ1</accession>
    <name>A0AAV6TXJ1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000886">
        <property type="protein sequence ID" value="KAG8176403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXJ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="157" mass="16876" checksum="4DC7FC0DB69E8239" modified="2024-11-27" version="1">MTEDPGPDPAQDVAIVDRGVGLIAAIVEMTGHVPEARRNEQANPRVALEARAETETETKNTGNLAVEAGAILLNNLWGTSSEVGLKAPNLKVEQQTDHLRKLSEKDDYCSAFLFKGAVVCCNWCGEQWQSHGAVVSSGVLSSSRERQVPGIKIRVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYU7</accession>
    <name>A0AAV6TYU7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_023676</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000857">
        <property type="protein sequence ID" value="KAG8176672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYU7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8176672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="359" mass="40961" checksum="8C2E9C20074C76C1" modified="2024-11-27" version="1">MCTLEPTKCIWNQSNFCNRFPRYCLKDKDPMKAMPLGPETSDYSLAYLNVVGQRQKDLVNYCSIVTGPNSYKPCTNVVSEHVVNWQGHPNTCFTFESLWGQPDAQPMIIPVTGKVIVELLLHPEEYVFHYESVKAHVMVHDSRALDNPTREGITLLSGRTYNIYVSQKVTLRLPAPYRTNCTNYPKLWRENGGRGPLTRKSCLAKCKMERMLQIFGCVPQSISYPNNNTICDDNRILEIFPSLEIVEGCSRECADACVETTYHLRVEVDGEQSLQCAANDTNCKQERMKLYFIFNRFERTVFAHQPKFESVSLFSYIGGFMGLWLGVSLVAVFDLAETLVNLLVIYPLSQSSRKKTRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZA7</accession>
    <name>A0AAV6TZA7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000862">
        <property type="protein sequence ID" value="KAG8176619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZA7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9914" checksum="32E69F6E830746E2" modified="2024-11-27" version="1">MQFTRKGFPPDAFEKWISSSDAPAHEPSLMRLPLIPPCSYQESISRFVRYHHGSELWKIVFPPKIRNVVVPLDISPLKTLYQTMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZS4</accession>
    <name>A0AAV6TZS4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_028210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000795">
        <property type="protein sequence ID" value="KAG8177254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZS4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8177254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="555" mass="64068" checksum="C407FCB63C1D46CD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZW4</accession>
    <name>A0AAV6TZW4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Speckle-type POZ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000773">
        <property type="protein sequence ID" value="KAG8177565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZW4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="16047" checksum="F3331452F330E5AC" modified="2024-11-27" version="1">MAHSNGRLHTSNPKSDYTFSWTIENFHMTTSLKVQGAEFLPIPDDKYESLVSLYPVAKKYQVKSLQKSLFVLLSTNLSVDYVCEALVLADLHGDKELKEIAKIFARENFVDLAGTVKWVELVTTYPKISREVLDFMKPTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U490</accession>
    <name>A0AAV6U490_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000651">
        <property type="protein sequence ID" value="KAG8179077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U490"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="25151" checksum="A6F8C809E9CA7C60" modified="2024-11-27" version="1">MEVSQIEKLDASNYGVWKEDVRVLLMERNCWRITSGEEKYPTEVEPDEKSTPAERSKDLREKAKEIKDFSIRRDKAYTVQAIYRWEDSRFTFNKILEELLAEESRLKKCQKDQSFSAYYVDSPSSNQKQVPSSNKSVTIKPVTKTDEHHPRGRKSRPKGRQPQSKDEEPLHFQDNGTSLLIKPATSSTLFSLRVKRTKVRGSSTQLQVYTCAVRKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4L8</accession>
    <name>A0AAV6U4L8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000655">
        <property type="protein sequence ID" value="KAG8178984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4L8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="7944" checksum="279E2FDD16190B99" modified="2024-11-27" version="1">MPSKIREKQRPLSPLIIQSRLKMALLADRNGLGNRGSLTHWPCCAGGLEEGLSSPALFSHQELFVDISVWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4Q9</accession>
    <name>A0AAV6U4Q9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_015361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000665">
        <property type="protein sequence ID" value="KAG8178808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4Q9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="66"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8178808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="137" mass="15200" checksum="81854B2906A27C0D" modified="2024-11-27" version="1">MNSIPSAIFGHLLETVRSDYEEQEKLSEGTLSMLLSLFDSIAIEALDLVDHKCISLITSPSGRELYKVERSASEFYICLKNSNYCSCPAFTFQVLKKGLMMCKHKLAASLCSAMGLCNKVQYADETVVLMLLGENNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7E6</accession>
    <name>A0AAV6U7E6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_002819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000603">
        <property type="protein sequence ID" value="KAG8179778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7E6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000020">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF56">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8179778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="221" mass="24311" checksum="28AF6B2681B6BB1E" modified="2024-11-27" version="1">MRAVYPKCRCKPGYVGNSCHKAVCQHGCKNGGECVASNKCACRSGFTGKDCSQPYCSPVCQNGGECVKPYFCNCPAGTKGNFCEKFLCKPECQNGGICVGKGKCSCPRGYVGYHCEQAYCPGGCMNGGKCGKTGKCVCLTGYTGLRCETKKPCKFVEIKEPYKRGYKQKVVTQAQVPCGAWGWKMCTKTKVHYEMVFKTFYKTTYECEGKTYPEYQKLKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7S7</accession>
    <name>A0AAV6U7S7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000565">
        <property type="protein sequence ID" value="KAG8180382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7S7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043349980" evidence="1">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="134" mass="15837" checksum="E6850EB26CA60CB7" modified="2024-11-27" version="1">MQFLLITSALVIFHCTVSQEISRYQLKPAANQRAYQTAYQPYNYYPQRASNYRYDNSYESRDESQYYPSTYDLVGSQLLMISGGVYKPDYSEDEYSSYSTGYKPYAYDNGYKYYDNSGSRYPRKRYGQQGAVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U863</accession>
    <name>A0AAV6U863_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 11">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_002833</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 11"/>
    <dbReference type="EMBL" id="JAFNEN010000603">
        <property type="protein sequence ID" value="KAG8179795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U863"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000002">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="13">
        <location>
            <begin position="42"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="95"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="164"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8179795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="267" mass="29659" checksum="574DF65C0C47DA33" modified="2024-11-27" version="1">MASTPSPKKCSRFSFRRKRDDSGSKNSSLLVESPKFISQEEAINIDQELFNEYKFSVDQLMELAGLSVATAIAKSYPVQDMGKKGTLLVVCGPGNNGGDGLVCARHLKLFGYEPTIFYPKRTNKTLYESLTIQCQEMDIPFLSFLPDVKLIDDSYNLVVDALFGFSFKPPVRPDFEDCLKKLKNLSIPVCSVDVPSGWDVENGGDDGLEPEFLISLTAPKQCSQFFRGKYHWLGGRFVPPSLASKYELNLPTYPGTECCVRLPPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U992</accession>
    <name>A0AAV6U992_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_020888</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000557">
        <property type="protein sequence ID" value="KAG8180662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U992"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF111">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE-LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="31"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8180662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="618" mass="70141" checksum="34B0E73D44D9031E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9D8</accession>
    <name>A0AAV6U9D8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_024701</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000539">
        <property type="protein sequence ID" value="KAG8180952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9D8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8180952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="162" mass="19054" checksum="5B059428DBFD9494" modified="2024-11-27" version="1">MVNTCVVPGCRGNYDKNEKVTLFRFPKDKFQLQKWVSTIPRENFTPSKHSRVCLRHFKEEEIRRHTEAFENGQKLSVALQQPRLKDGAVPVIFPGSPKYLSKEKVHRPCPDAKKEIMENNQLALAIQESLKEKELYEEKYTFKNWDELILCLNNLSIPSYWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UB94</accession>
    <name>A0AAV6UB94_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_017725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000505">
        <property type="protein sequence ID" value="KAG8181605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UB94"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051963">
        <property type="entry name" value="Adhesion_GPCR_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930:SF4">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043361251" evidence="5">
        <location>
            <begin position="20"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8181605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="312" mass="35762" checksum="AD1A59E9A0C13B95" modified="2024-11-27" version="1">MAFLLPICVFVALVISGLGAPITCPSTEDLRPCTCKRVSYGLEVMCANFNTSSNLLRAFRILRDYDVQTILLHGLYIQEVLPNDLFDGMKVSAIRVERSKLKFSQPAFSGLGPWLHVLNIAQQSIIKSEERFSLAKLTKLNELIVQSNHLDRVEDKWLNEKVPNVHKVDLDYNEITLLEDHAFSKLQSLSLISMADNRIKVIKRSMFPKPALKLSRIDLSYNEISNIPEDFFLEMPNLKEVILSGNELKNLHEATWKPVWEQLRKVLLFENHIDCGDYIKWIKKYREPGQLAGTCVLPKSLTGHHIKDLYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDP4</accession>
    <name>A0AAV6UDP4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_017476</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000521">
        <property type="protein sequence ID" value="KAG8181306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDP4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8181306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="231" mass="26944" checksum="D764F2469093809F" modified="2024-11-27" version="1">MVNTCVVPGCRGNYDKNEKVTLFRFPKDKFQLQKWVSTIPRENFTPSKHSRVCLRHFKEDIRRHTEAFDEKGQKLSVALQHPRLKDGAVPVIFLGCPKYLSKEKVHRPCSDAKKEIMENNQLALAIQESLKEKELYEEKYTFKNWDELILCLNNLSIPSYWTFLKTEDAIILMHVSMTPYPAISKSIVIDKKCSVNVFLEKVPLTKVEQNYACMPMCLCHMDLGSWTLRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UET8</accession>
    <name>A0AAV6UET8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bursicon beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000472">
        <property type="protein sequence ID" value="KAG8182263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UET8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031395">
        <property type="term" value="C:bursicon neuropeptide hormone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034441">
        <property type="entry name" value="Bursicon_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41151">
        <property type="entry name" value="PARTNER OF BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41151:SF1">
        <property type="entry name" value="PARTNER OF BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043697796" description="Bursicon beta" evidence="1">
        <location>
            <begin position="25"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16928" checksum="CCE7ACD364B10A9E" modified="2024-11-27" version="1">MPSNSKKPSLIWWWSILTLSLAYCREHNEQDEELAQVVAKGSEAVCETLPSTIQVAKEEYDDLGNVVRSCEGTIGVTKCEGTCNSQIQPSVVTPTGFLKECHCCRETWMRQREILLTDCYTQDGKRIFGQQGTMVIHLKEPEACACHKCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF83</accession>
    <name>A0AAV6UF83_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Follistatin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_024435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000431">
        <property type="protein sequence ID" value="KAG8183132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF83"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16231">
        <property type="entry name" value="EFh_SPARC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01328">
        <property type="entry name" value="FSL_SPARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000234">
        <property type="entry name" value="Protein BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015369">
        <property type="entry name" value="Follistatin/Osteonectin_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037641">
        <property type="entry name" value="SPARC_FS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF14">
        <property type="entry name" value="BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09289">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Follistatin-like" evidence="7">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8183132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="342" mass="39196" checksum="ED7553479D950B59" modified="2024-11-27" version="1">MSQPHRSLIPGNFSAHVPASSISDVWQPSAHLPVSPIPVVSQLQTPSLRNLQEESSECLNKEKMTRLGILLLLVQCIPYIVSKELPQASVEKDQLDLIAEDDSLNEIDVESSSNEVEGGYVPDPCQKVRCGTGKVCEVNDKGEGHCVCISKCPQETDDRRRVCSNHNETWSSDCEVYRMRCLCTENSDECKTKKYKHVHVDYFGECRDIPKCSEEEMEDFPRRMREWLFNIMQDLALRAELEDPYLELEKEAERDLHKKWTNAVIWKFCDLDSHPFDRSVSRHELFPIRAPLLAMEHCIAPFLDTCDADDDHRISLKEWGLCLGLKENEIEDKCANIRDSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFU3</accession>
    <name>A0AAV6UFU3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000458">
        <property type="protein sequence ID" value="KAG8182598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFU3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="501" mass="55499" checksum="D3CC62032EA22451" modified="2024-11-27" version="1">MDKILQSERFEAIYRFKIPFRSGSFKKSSRNMEKAVIMDAEIESETPDEPIPVTYLEIVVAEPTTVLEIGVQEPTTATECLAAEAPKMVVEDTDAAECLAAEAPKMVVEDTDAAECVAAEAPKLVVEDTDAAECLEEPTTVLEIGVEKPTTVLEIGVEVPTTATECLAAEAPKMVVEDTDAAECLAAEVPKMVVEDTDAAECLESETPDEPIPVTYLEIVVAEPTTVLEIGVQEPHTVLEIGVKEHTTNDVWLLFQYDVFLLNLLAAEAPKLVVEDTDAAECLEVEKNIISDDETTEEYDPEEEILNFEDPDKDVNERALKEGTSSLEDPIKDKEEKAYLKVGVIHFEDSDNVSDEFIYMKMAASTVDSEKVKLEKSYLKVEEEQMDGKAKNLANAEIRAASKSEIEEKPKEKEADNSAPAATSSPIRKLRRIESRRQIFPRKQFPLESLMPSPMNAVIETDQQEGADSVQKEPITLQEEGDVPTFPEILFPFNDDEDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFV1</accession>
    <name>A0AAV6UFV1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000421">
        <property type="protein sequence ID" value="KAG8183337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFV1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="477" mass="52943" checksum="48DAAD3F883031D9" modified="2024-11-27" version="1">MCDPVIISKLYASVLHEDILKYHITNSDIRTGIQNMKEVYLPNPMSLTSDHLDVANYDDPAHRCAYLHKYAPFHTGMVAEMLYRAVLDNPKVFRDLLLSSGSLSICSLGGGPGSDVIGVMSVLNSSFGFFQVSATIVDCMPNWRQTFASLIQELRYGAYGTLGQCVTDQYFSWNYLGCNLLGTMSNDVNTAISRANLLTMIKFVSASACKDTPAMIKKIFRVMKPGALVLYIDNAGGGFHQLVRTEAQLCNLITVFGPLEHEHYVTNDYNIKRFGYTPCLETKVTVHIWRKPSSDSAVQRESNRGQPKNNLNRSRSSTPGRANTSRSRSSTPGRANVTANAWNNVVKNYQGVPAQNLDNRRTSTPDNKVNSRNFQTMNSQTIDNRRPSTTGSTANRNLQGVQSQNVNNRYPNFCAPVIQSTNVAQSRPRGRSPTRSVIQQPRNIHYARPSPGSGYRPAPSEDRAEQEGEQCCCCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFV8</accession>
    <name>A0AAV6UFV8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_018318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000463">
        <property type="protein sequence ID" value="KAG8182435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFV8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="228"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8182435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="579" mass="64858" checksum="F8BBF9FA689F7F51" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIR8</accession>
    <name>A0AAV6UIR8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000385">
        <property type="protein sequence ID" value="KAG8184167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIR8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10916" checksum="C0ADC68FAB418FCF" modified="2024-11-27" version="1">MIRQLLWEFSQRNFRLALEWVRGDSGILGNEMADEHTKSAAESQLPHCFNKVPLCFFYKRQQHLKTLNLWQNDWTSTQKGAVTKLFFPSVAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJE9</accession>
    <name>A0AAV6UJE9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_025707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000402">
        <property type="protein sequence ID" value="KAG8183823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJE9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15949">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15949:SF3">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8183823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="282" mass="31222" checksum="016349E74D66CB3F" modified="2024-11-27" version="1">MSSEVAEVTSPDVIMILIPLLLLLLLLTIGILVWHSGLFITPDVKTCKPPFDELEVAYKFVRGSHKDCSLVYAEAHSLAPELRCIGVYYDNPEEVGDSYMRSIVGVILNDEGKTLSEEDRQRMLVKGFQITKFPAVELVVCADFPHSSFLSVLVAVNKVVPCLKAYIQEMKLQAYPLIEICDGQQILYAAPLSKQSEFFVFEALAESEEDITSEKTVDETEELSTKDLEELPDTVSSVEGAGSKVEELPSNEEILESLEDKNKGSNGSEASTESFEELQLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKJ3</accession>
    <name>A0AAV6UKJ3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Nuclear nucleic acid-binding protein C1D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_019333</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer and homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
            <location evidence="10">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the C1D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000363">
        <property type="protein sequence ID" value="KAG8184731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKJ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8184731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="330" mass="37467" checksum="C86E9414F43C77DE" modified="2024-11-27" version="1">MSEEMDIPSEILEDLQSFHENLKKMEETLNPLIKTNVNSLDVKLLPLDRARLNLISGYALNSLYWMYLNTLGEDPKHHKIKRELERYKSFMQTVKEITDKDKAPVLDKGAAKRFLRNALWEPSGDQSSNKTRNLPCTVNNSYDTVVTVKKEPDTNTNNSYKTNAMQTNSASFNINQGTCVKQEARVNFQGSSATVYLPHTSKAPCSSNLGIEEDEDYSHQAIELPTTGRKFIKAKRSIKRHTQKTIIAEEVVYDLSCGLCFVPAMQLKQRKSFPVFLLSCGHFYCGPCIWGWRDGASGSQSSSPSQVVGDEVEKAQRKPRDGHKNKRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UL39</accession>
    <name>A0AAV6UL39_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_017025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000349">
        <property type="protein sequence ID" value="KAG8184999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UL39"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033514">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via L-pipecolate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8184999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="383" mass="42252" checksum="5839EA765F1494DC" modified="2024-11-27" version="1">MSKVFEFDHAVVGAGIVGSWTALQLVRLGKKVILLEQFPDLHTRGSSHGHSRIIRSSYDDACFARLMPDALHMWSEAEVETGVHMMKTTGLLCLANSDFGVDLVEKSVENMKKYCPVGLDTDVDRISGIMEGVVKYDNLRAAMLDTTGGVLFAHKCVKTIQTLFKERGGELWDMSPVSCLDPDDEGVYVHLDADRVVHAQSVVVCAGAWTKKLLQPFVTLPAQAQVVRVYYFKEKKLGAYSAENGFPTLLEVGKTDIYALPSLEYPGLVKVCLHGGVPCDPDARDQTPQKPEFDALIRSYVAEHFPLLETEPAIVETCMYTTTPDEKFIVDFVPQHKNIVIGTGFSGTGFKTAPVIGRLLSQLATGSEPFLDISAFRLSRFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UME3</accession>
    <name>A0AAV6UME3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BACK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_020014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000352">
        <property type="protein sequence ID" value="KAG8184968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UME3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BACK" evidence="3">
        <location>
            <begin position="116"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8184968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="332" mass="38657" checksum="F76C4164B3C80F8E" modified="2024-11-27" version="1">MAKTFRRFLNNLTCCLSGRNRTTIDDSEYFNVIKTADGKTSKEQHTKIKYPQITTSGLDNPFIITEIEELNYLIKDLYEEKKNETFSNNRIPLIYQQINIKMVQLIDLTSDNMEFFLTMYKTDNTVGARRAFRSAAKAMALHFDTFVANKSFLNLSLNQLTTILRQEKIATKSEIDLFQVAVYWINQDYSTRQHHAIDLFRLINFSALTMPQLMQCYCHQPDLFQSSEVDIILRNAAIFISLKYLGKELTVFAFAPNPREFTIVPEPSNPFDPVNPFDLNTVKLMEEEASLSHQSGGRRRKRIHMRLRVIWCQENNGILYHLEDLPIDENIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNC0</accession>
    <name>A0AAV6UNC0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000326">
        <property type="protein sequence ID" value="KAG8185695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNC0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="172" mass="18216" checksum="BD4DFF7D17726DCB" modified="2024-11-27" version="1">MQYFGWMAAGHSSPVLFLTNSRDAVDVEGGDDSDDDIHIHTAFTNGPQNGKAMTVADENSTSDLPAAHPATSLSIVTRGRESSLRGRRTYTPGPGKVGSRLRISNLDIHDTGYYKCEALSGGAPLVSEGGPSHQPRVESTGILIVRAGRIQPPATIPNFPPVFPHFPALGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UP67</accession>
    <name>A0AAV6UP67_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000337">
        <property type="protein sequence ID" value="KAG8185375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UP67"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="9342" checksum="795326E166D16947" modified="2024-11-27" version="1">MTTSSFLYSIRPTFDVNTFTASHQQKVHVAKAKSLNGIELWIPEWDIMDVVWGSRAPKCRTTTMLMYACFVEVTRQICHIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQP6</accession>
    <name>A0AAV6UQP6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000289">
        <property type="protein sequence ID" value="KAG8186780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQP6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9380" checksum="244570B51309AAA0" modified="2024-11-27" version="1">MGALADPSTPLAPSLISHLHYTISSHTTRSKTAEKKKNDSSLTREHTHRITINNKDGPRPLANNDGRELGALLKFKGSWAHAADKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URS6</accession>
    <name>A0AAV6URS6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000283">
        <property type="protein sequence ID" value="KAG8186955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URS6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="993" mass="109115" checksum="578D32B3F605A6BF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU53</accession>
    <name>A0AAV6UU53_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000289">
        <property type="protein sequence ID" value="KAG8186781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU53"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="8706" checksum="B2BCEA252AE453B3" modified="2024-11-27" version="1">MGFIKYRERELQLPPTSIRWLSRDVTNKGETQEACLASDSSGVIAATKDKNDMCHGHAGLKGLRLGGVWTMAERVTVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UW48</accession>
    <name>A0AAV6UW48_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_009916</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000251">
        <property type="protein sequence ID" value="KAG8188042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UW48"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043338917" description="Cytochrome P450" evidence="16">
        <location>
            <begin position="20"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8188042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="61084" checksum="B71B258EBAFC2A58" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXH6</accession>
    <name>A0AAV6UXH6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000241">
        <property type="protein sequence ID" value="KAG8188349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXH6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="114" mass="11800" checksum="79B6A9071DE1B460" modified="2024-11-27" version="1">MSSAGGTTNREETIPMLMLNHSDSREDSLPRNNSSTRIEILPSTSAPHSPPTKDAGANCTRNPSNGVPSPAGSQRPAYTNQPQALNLMQFVEPPPGGPSPPKTPSPASVAAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZ39</accession>
    <name>A0AAV6UZ39_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial nucleoid factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Mitochondrial protein M19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_018504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000208">
        <property type="protein sequence ID" value="KAG8189655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZ39"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037698">
        <property type="entry name" value="UQCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34260">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34260:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8189655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="119" mass="13676" checksum="667E87AC26769EE7" modified="2024-11-27" version="1">MAAQQLYKSYLRLCEKWGVDSAKKGRDLGEFIRQQVGKEFSQGGSTNIQNLKECEQKLASLNRLANNQYGDKYRWTKPVTASTLSLEECQRVLSTAGLQEINENKLSLWEKMKQFINKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZF3</accession>
    <name>A0AAV6UZF3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000227">
        <property type="protein sequence ID" value="KAG8188936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZF3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="12495" checksum="C90D95F9CE447D3F" modified="2024-11-27" version="1">MAPYFFFRVETRVLDGVRDLWRTPFHLVERQTAPRLECPKRDRRSFRPGNDDSRSQWPPDNKCCFGAPRISYQQWKQFSSENCFVSGTRDEAGFPRLVHSRRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0A0</accession>
    <name>A0AAV6V0A0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_011922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000191">
        <property type="protein sequence ID" value="KAG8190200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0A0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043697810" description="Neurotransmitter-gated ion-channel ligand-binding domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="2">
        <location>
            <begin position="30"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8190200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="159" mass="18319" checksum="AD9718F74075DE64" modified="2024-11-27" version="1">MNKKAFLKLVLQVFILKIRFNICKSNNPAEKLCTDLLPDDYHIEKPSEEGIITDVLTWIQILDFGDINEAKMDFAFLAYVINIWNDSRLKVDSYKTSGQATILYAGCRDYIWIPDIIYESAKDVKADQKFVPSTLLKVLPYGAIYLSTLYSFRARCVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V225</accession>
    <name>A0AAV6V225_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000202">
        <property type="protein sequence ID" value="KAG8189845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V225"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="154" mass="17139" checksum="17E31E12DC97EE24" modified="2024-11-27" version="1">MPTRNMPGFSIVCVDNGTDGVILLSITYAVMTSRGQIVIGARSGVEKCVDRGATKVACDHNSDESHACLHHKTKNVRVSNIKININKLGTYADQRSNTLAGKLTLGQVTRRLNTWSSDSPTLHLVTFHEQTLFKCRWRRALNRRDCMGLVKNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V244</accession>
    <name>A0AAV6V244_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_009095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000199">
        <property type="protein sequence ID" value="KAG8189956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V244"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OAR" evidence="3">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8189956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="185" mass="20536" checksum="5D1513F2BE3B1D8F" modified="2024-11-27" version="1">MQRKSQEAAERLNESDHSSDGHTSDQHTSSNQHQRTMDQQASASSTQHHQPSFINQPQDQSSLVYSQHHHQVSSESSSSRGSSPVRGTTSSNHHSQQLQPTIGKEDERPYHSQQQRPSTTIKEDFRSSSIASLRAKAFEHASRVFGEDRKLTETHISDAGAVATAVKDTPVVNERPSIHCISSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2M9</accession>
    <name>A0AAV6V2M9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_029492</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000168">
        <property type="protein sequence ID" value="KAG8191052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2M9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006589">
        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.310:FF:000004">
        <property type="entry name" value="DBH-like monooxygenase protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.230:FF:000001">
        <property type="entry name" value="Monooxygenase, DBH-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1210:FF:000001">
        <property type="entry name" value="Monooxygenase, DBH-like 1, like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028460">
        <property type="entry name" value="Tbh/DBH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF23">
        <property type="entry name" value="MOXD1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00767">
        <property type="entry name" value="DBMONOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="607"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="13">
        <location>
            <begin position="37"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8191052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="626" mass="71327" checksum="0045AFE41A0EED83" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2T3</accession>
    <name>A0AAV6V2T3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase I subunit RPA49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_006038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000194">
        <property type="protein sequence ID" value="KAG8190100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2T3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8190100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="45663" checksum="048CD94A82E711E3" modified="2024-11-27" version="1">METSDMEEETNTCRFKVSSKLKKRIPVFLTDFGHSQVKMNKESNVLKFESFKSDEDVADISVNANRKLLANSGHTDYAGSTSKEAHPFRYMIGVRDKNTGKMKLFDSVLFRMKPVLKFEETDTQVSAAKTYWEGLKDLTQTFGIKSQKRAMSAHLKNAANASIDESMINASDLERSVLVSASQNLEYLPTINREAGSVGQVFDIYEIITPEEDGILEQEAKSIIDDDEKLAELKAHSCKYVATHLQNLHNDVQKAKYLIYFNYLVVFQHLRYQDIQKKDVIKDIPQPIRKKLLDDFTVTSIKEKTGKALRGYPMQMKDKVLSRILVLALFIDDFLVNMNSLLGDLNQVWEKKLTDMAHALGCHVRNLKAGDDTVKCVELKLPLYVLMPKYAKKQHSSSKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2Y1</accession>
    <name>A0AAV6V2Y1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hsp70-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000175">
        <property type="protein sequence ID" value="KAG8190747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2Y1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31860" checksum="35C38F2A313F0C19" modified="2024-11-27" version="1">MQVCCVDPQPTFILPPSDIDKMKAQLALIDKFMNDIEKGEATSITFDDITNAVTVIDGIILSLDNSNDFFKIGGFKRLVPLLNCPNAEVVATTAELIADLCQNNTFCQTKALELGILSELVKQLANPIDPKVRLKSLYALSCLCRHNEESIKCLSESNAVQVLLQILHEPDEKLRTKTAFFITHLSEHENFREAFYSTDLVPTLIKLLSSEQDSSSEYLLSALENQVSRHLQSRVQSSSDEYNLLEILRTKVKLYNSEEEFQESTEYCKKLLALCFPDAKLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4T5</accession>
    <name>A0AAV6V4T5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_016471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000154">
        <property type="protein sequence ID" value="KAG8191684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4T5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043697814" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="71"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8191684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="729" mass="82162" checksum="F3C47E9280ED5187" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V642</accession>
    <name>A0AAV6V642_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Striatin-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_009966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STRIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000143">
        <property type="protein sequence ID" value="KAG8192205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V642"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="4">
        <location>
            <begin position="409"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8192205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="793" mass="91515" checksum="C28DD52FAC0537F2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6F3</accession>
    <name>A0AAV6V6F3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Speckle-type POZ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_002136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000141">
        <property type="protein sequence ID" value="KAG8192315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6F3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="18"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8192315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="40119" checksum="2EE5CDB35C7D1B96" modified="2024-11-27" version="1">MSEIVNEVECRTKILVETCNFKWSIENFSVICSIKTKEKKFLISPTFTIGETSSTKWCALMNFHEDVNFINIYLERSSSNICTHHVSYKVSIIGSDTTKYLAYDTGNGHLYDKNTPMWGYTKSIQRKILFEENSLLLLPNNTLTVMFELKVSAEENIDEATYLAVPIVLKETDSLVGDMKHLYENKMFSDFTLKVGNEELKVHKLILCARSTVFNSMLTTDMKESITHCLEITDFDPHVVKAMLQYIYCGQVEEIIPDLGIQLYSIADKYNLQDLKNICVKFLLKNLNVSNICDVLVLCDMHNEPELMMAAKKMFCANAAAVQETEKWIDLSKKMPDLSIAMYRFAISQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6L5</accession>
    <name>A0AAV6V6L5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_019792</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000150">
        <property type="protein sequence ID" value="KAG8191856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6L5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF116">
        <property type="entry name" value="DOUBLESEX-MAB RELATED 99B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="8">
        <location>
            <begin position="217"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="217"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8191856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="450" mass="51718" checksum="AAA21836B0777337" modified="2024-11-27" version="1">MHPKQLHNYNMQKGGVGEHCHEKAWYIQENMVTADKEFHGYAYPKSDEVVEHAKEMYYQQSPKEESRHEYSRKKPRKTRHCVEGSDLVEITKNDSVMEHEEILYQQSSKKRRHELDEYPHNEPGKTMHRGKNSLPRETAENPQVPPGKKPQRRVRYAKGTSSGQKKSLPPQPLQTLDNSTVVMANGDLNLPEVIKDDTLPDDEVSNEEKKVTRQPKCAKCKNHHIDVLVKGHKHFCPYKKCNCKLCEIVKNRQDIMKRQISLTRYQKEVEARKLRARILRARILRAKQLQLVGIQKDEVEQLEAQELEAEQLEAQEEDIEQVEVPEENEEASLDVVGISSGNVTPEPKHASAFATSQAKLDPSQTAAIYSRSLKARYNFGCGGAWEKSNASNQRYPFISRSDSDGETCQPELCRQSRQGCRILLLSRDCSDICRPKKWHGPVAGGWRLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6S5</accession>
    <name>A0AAV6V6S5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_021168</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Endoplasmic reticulum membrane</location>
            <topology evidence="2 11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the OST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000157">
        <property type="protein sequence ID" value="KAG8191563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6S5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039491">
        <property type="entry name" value="REX1-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14966">
        <property type="entry name" value="DNA_repr_REX1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043100895" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="11">
        <location>
            <begin position="20"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="505"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8191563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="597" mass="68205" checksum="381BEB794F0A818B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7I8</accession>
    <name>A0AAV6V7I8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000142">
        <property type="protein sequence ID" value="KAG8192231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7I8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043574435" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26427" checksum="0C08D67D5ACF94E2" modified="2024-11-27" version="1">MQLEMQLSVVLVLALVAGSSGAAIENCHMERLMQCGDALSSFRREQGESFPTTEEQVKKLCKNLEEAKACAETFQNKCMTPLQLETMGFLTEGSLTVYRDFCTEGSEIREEYLKHSVCLNDATKTDEAKGYYEYVEAALEDLTEKPAAKRLPTICCGYQWLTNKFNKMGDEKCGEDSVDSFHNVVYMAVSTLPDILCSGFDPDSAQCTENLPPAGAKPKGTIRNSHIAKTFSSMYLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V851</accession>
    <name>A0AAV6V851_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_005392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000145">
        <property type="protein sequence ID" value="KAG8192095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF63">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="298"/>
        </location>
    </feature>
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        <location>
            <begin position="790"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1077"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1304"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="336"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="790"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8192095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1337" mass="153023" checksum="7321098D74F4F81B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8M9</accession>
    <name>A0AAV6V8M9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="12">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="12">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_002101</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="12"/>
    <dbReference type="EC" id="1.14.15.46" evidence="12"/>
    <dbReference type="EMBL" id="JAFNEN010000141">
        <property type="protein sequence ID" value="KAG8192275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8M9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000111">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000086">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01989">
        <property type="entry name" value="COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0274">FAD</keyword>
    <keyword evidence="3 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="296"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8192275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="420" mass="46186" checksum="80DB7A93D6B2B626" modified="2024-11-27" version="1">MVGCALAASIGASPILADKKVLLLETSPKTEYSINPNKYSNRVCALNKSTKSLFESFNAWEKICNIRMKEVRKMVVWEACSDARISFSQDGMQDEVAYIVENDVILNVLTNTLNDMSDKIDVLRGVKANDYQLPAIETDLVTVSLESGVPLKTKLLIGADGVNSLVRKKMNVKYISWSYDQKGIVATLKLSEQTSNIVAWQRFLPTGPIALLPLTDDLCSLVWTVSNPMCEKLLKMTDEQFVDSLNTALWDDESKNTFVESAISNLRSLLSNLSAEQSSVRQLPPSILSIEEKSRAAFPLGLGHATEYVSKGVALIGDSAHRVHPLAGQGVNLGFGDVKCLTECIEKAVYDGDSIGSIDYLSEYETIRQRHVVPAMFAIDALNRLYKTEFAPIVLMRSLGVTALDALHPIKSKIMQQASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V959</accession>
    <name>A0AAV6V959_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein FAM76A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_014600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000134">
        <property type="protein sequence ID" value="KAG8192816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V959"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032017">
        <property type="entry name" value="FAM76"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176:SF1">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16046">
        <property type="entry name" value="FAM76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8192816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34988" checksum="3D11FBC5E9DD08DE" modified="2024-11-27" version="1">MAALFACTKCNSRHPFEELSQGQQLCKNCRGSFPTVKCTYCRTEFQDESKGSPALVCKKCEYNVKLYGKPSACEYCNIIAAFIGAKCQRCTNSEKRYGPPTSCDQCKQRCAFDRKDDSRKKVDGKLLCWLCTLSYKRALAKTIQGTSRHSSSSKSHHHSSQNHKRSSSHSSKSKKSEHSPSKKPRIDITKSSSNGSLPTSEKSTLLDTGTSDHVVAMHQLIDQIASLEKQLLVKDQEMLSREKTAAEQKSQHSLIERELRLKIQTMQKSHGDIVEDLQSKVRVLQKQVITLTKENKDKKRNKDTDSPQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAA3</accession>
    <name>A0AAV6VAA3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000118">
        <property type="protein sequence ID" value="KAG8193589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAA3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="109" mass="12549" checksum="A04468A5FEF04DA1" modified="2024-11-27" version="1">MKEGGVLEHWKMKYNPQRDECYGIKTSVPGQREVSVEDLQGPFYLLLIGLVAGFVVFTVEAAWHRRKSCRKKPPSKHGKRNQCFIPEWQLSTDTALKKNRDVPNVCFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAG7</accession>
    <name>A0AAV6VAG7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gelsolin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_014629</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the villin/gelsolin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000134">
        <property type="protein sequence ID" value="KAG8192853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAG7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11289">
        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11292">
        <property type="entry name" value="gelsolin_S3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11293">
        <property type="entry name" value="gelsolin_S4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11288">
        <property type="entry name" value="gelsolin_S5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000001">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000002">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000005">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF123">
        <property type="entry name" value="GELSOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0117">Actin capping</keyword>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="10">
        <location>
            <begin position="28"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="10">
        <location>
            <begin position="149"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="10">
        <location>
            <begin position="273"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="10">
        <location>
            <begin position="399"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="10">
        <location>
            <begin position="529"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="10">
        <location>
            <begin position="635"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8192853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="725" mass="81216" checksum="C2CB0CF8E296450A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBW5</accession>
    <name>A0AAV6VBW5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras-related protein Rab-18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000120">
        <property type="protein sequence ID" value="KAG8193479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBW5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001329">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26109" checksum="D8CC35B23912CCBA" modified="2024-11-27" version="1">MTEQRKLKIIVLGESGVGKTSLLVRYKDGTYRESYKYTNLDLLTKTIRINNTSIHLEMWDTAGFEKCRTYVRGYFRDSHGVLLIYDVTNMTTFNTLESWLSDLRKENETAVVLIVGNKNDDPDRKSVNRKVVKGYAESKDMEYMETSAKTGDNVNEVFDTLIRRILGIPLDDNTDSSNADSGHCSDAEEAISNNRKVYKLPPIVPLRDEGIIKLSAQTDKLRKDDDFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VD35</accession>
    <name>A0AAV6VD35_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VD35"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="12098" checksum="C69B12CED6DDC548" modified="2024-11-27" version="1">MPKIWEHVKERTSIMTRCDGKEHRKRVNRPCKKAPAAKAPVVRLRASAIQPSKMKGKGLFLYNECIHLEWRFDEREILLWGSSEKHGVPIDGMVAFLLHPNEPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDQ6</accession>
    <name>A0AAV6VDQ6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-catulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_021386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000096">
        <property type="protein sequence ID" value="KAG8194925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDQ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030045">
        <property type="entry name" value="CTNNAL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342:SF1">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="737"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8194925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="771" mass="86191" checksum="69640859AD9B87CD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEE4</accession>
    <name>A0AAV6VEE4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000110">
        <property type="protein sequence ID" value="KAG8194036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEE4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35767" checksum="F3CD86117AE7F45C" modified="2024-11-27" version="1">MTSFTFYHLYLIAVHGTFGYTAFMSTSVTVLPNMIWLYTWKKRTSLEKFLNLLTNKTSPCMKNHQLKPNVVNIFVIFGLIFPPIWQTLVLYSSGNFQKLHFKDLVHQYCGKTHELLFPTISAITYVALCRILVLRLRASHFQLRQIPSTTDPNKIKWTVENFLVVVRAIELFQETFSASIFFLFWHNFSQLSYSMMEALFEKEMYQQSLVLDSVFFVAHVCGVVGTVTVSAAEIPLEMQRIKSSLIKKRFQRMLKGPYLFGEQYTNMILQMDVFVLTACDVFSFNRGFLLTALGALMGQVLIIYQIITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEN0</accession>
    <name>A0AAV6VEN0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000101">
        <property type="protein sequence ID" value="KAG8194631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEN0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24840" checksum="3481A68FC4557E94" modified="2024-11-27" version="1">MQTVFVSSVGDFNKYFTERKVDIKNVTFPTDDVALLQYQHKNEFTAQNIQTNIFIAAFTTAYARLKLYGELNNLGTRVLYYDTDSIIYISDPSMNDPPLGNYLGDFTDETPGDHIIEFVSAGPKNYAYCTASGKSCCKIRGFTLNHQNSKLLNFNSIKDIVMNAPNKQVVTVNPYKIKRDLNKVRILSCREEKRYSFNFDKRVIRDNFVTYPYGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VG36</accession>
    <name>A0AAV6VG36_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VG36"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10511" checksum="50661B53D5E741AB" modified="2024-11-27" version="1">MSLRAKPINATNSKVIKKTSNSLLNSQLKPTQTILSGQRTLPKIPTEIQIGNRNCKWNSEYTSIFWMKMTLEQAGVFLGRIYRINKAENDAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHP1</accession>
    <name>A0AAV6VHP1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_027920</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000091">
        <property type="protein sequence ID" value="KAG8195176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHP1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15136">
        <property type="entry name" value="7tmA_Glyco_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000181">
        <property type="entry name" value="Thyrotropin receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF74">
        <property type="entry name" value="LP13728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="529"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="658"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="509"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8195176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="926" mass="105169" checksum="3309653D90878C78" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJH3</accession>
    <name>A0AAV6VJH3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000064">
        <property type="protein sequence ID" value="KAG8196759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJH3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030891">
        <property type="term" value="C:VCB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01788">
        <property type="entry name" value="Ubl_ElonginB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039049">
        <property type="entry name" value="ELOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248:SF4">
        <property type="entry name" value="ELONGIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="128" mass="14719" checksum="3698A3078FAC1C35" modified="2024-11-27" version="1">MNVFLMVRRKKTTIFLDAKENTTVYDLKKMVEGITKVPPENQELYKDDEVMEQHKILGDYGLNDSTAKAQAPAQVGLAYKESDTLGFEIYAVLIFFLQISSHGMCVEHFRSYLSSSEERAKWLTNLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJQ2</accession>
    <name>A0AAV6VJQ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_009581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000071">
        <property type="protein sequence ID" value="KAG8196363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJQ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF3">
        <property type="entry name" value="AT07710P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043775836" description="Amidase domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="67"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8196363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="521" mass="58081" checksum="AC0E6BFF84AEF40A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJT6</accession>
    <name>A0AAV6VJT6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_014483</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000064">
        <property type="protein sequence ID" value="KAG8196750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJT6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000016">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8196750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="118" mass="13158" checksum="C68783B718B6382B" modified="2024-11-27" version="1">MKLVRFLMKLSHETVTIELKNGTQVHGTITGVDVAMNTHLRTVKMTVKNRDPVQLETLSIRGNNIRYYILPDSLPLETLLVDDTPKAKAKKKEAAVGRGRGRGGRGRARGRGRGRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLV3</accession>
    <name>A0AAV6VLV3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 151B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_013839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM151 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000060">
        <property type="protein sequence ID" value="KAG8197003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLV3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026767">
        <property type="entry name" value="Tmem151"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14857">
        <property type="entry name" value="TMEM151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="417"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8197003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="666" mass="75304" checksum="08C124F35349194E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMD0</accession>
    <name>A0AAV6VMD0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000056">
        <property type="protein sequence ID" value="KAG8197316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMD0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="177" mass="19700" checksum="7025683657F5CB90" modified="2024-11-27" version="1">MPITPIHFEFTTQPTNLGGCDALAFPFKTTLYLPTYRQAVSSIIAVRLKLRSLHNKSVDTFFLLQIAPPTCSNVIKAFFYWYISFTAIFSETKSRPHILLVPKCLGCQIFITTNELIVAPNGTNPKKLNVHPACDGDRNLSSVYTLSLNDPLPVQPDYPKGLITPPNVSFLFHVGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMM4</accession>
    <name>A0AAV6VMM4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proopiomelanocortin A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000050">
        <property type="protein sequence ID" value="KAG8197794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMM4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="11207" checksum="0A1A2D5F97A696C3" modified="2024-11-27" version="1">MLQITILSEKDSTRRQKKTLLSFLTLRLNRDKNYHYQRSTSSSKDEDETQNPNGFLSISNNSPFQEKKKGQNNPPSSVNGQQIWDPHVWFPDVDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPM8</accession>
    <name>A0AAV6VPM8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_001587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPM8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11387">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8197658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="10021" checksum="5864A395FE4D3BB4" modified="2024-11-27" version="1">MSPAIMTEEKKFWTAPFDPRFPNTNQTKNCWQNYIDYHRCRKVKGEDHAPCDYFKKVYSSLCPNSWIDRWDTQIEEGRFPGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRH1</accession>
    <name>A0AAV6VRH1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000037">
        <property type="protein sequence ID" value="KAG8198666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRH1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8543" checksum="BB8FD84C6D3C1021" modified="2024-11-27" version="1">MTPAVFSPYPSFTRCEKYNHTPSIIHSIISVQVPQGYAKTPTAFPYPPYLTPPSQNKGALGISDDWGEGDGQKRLTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTS3</accession>
    <name>A0AAV6VTS3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTS3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="108" mass="12673" checksum="C05AEBD3DC1AE37E" modified="2024-11-27" version="1">MGRRLDSFIFGWPCPMLEAHLRGKVALEYIFLLMHKGEDRIPPRLQQNSKRGRKMKKKKNVEWKVRRVLMELVSSGWNDDSDNVQWSSGPRITPSTENFVLEDILGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUE7</accession>
    <name>A0AAV6VUE7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUE7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="109" mass="12436" checksum="A2FB868C3AEE5E75" modified="2024-11-27" version="1">MQKSESREEVNLNKGNGLGTKCEAYLRRKHRPFARHTRNWAELSKGSITQHDSKLQRSGVETIEELGHRENGTEPQADSPECSIMVKHLDTTTDFKGEIELKFVLSLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUK0</accession>
    <name>A0AAV6VUK0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000022">
        <property type="protein sequence ID" value="KAG8199978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUK0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF454">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="77"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="212" mass="23952" checksum="3885C2787068AC23" modified="2024-11-27" version="1">MCLIIRVCPTSKRPGFISAVKRIWVVKRYHSSPPVFSKTRRLSPEKLKIARQEFERLLADGIVVPANSPWASPIHMVPKKDKTWRVCGDFRRVNSVTVPDRYPIPHLHDFSHILSGKTVFSKIDLVRAYYQIPVEPADVPKTTVTTPFGSFSFVKMPFGLRNAGNTFQRFMHEVHLEGSSEGLRSLGSFLHPLSEVEGCPPHKVAAWKLPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUV9</accession>
    <name>A0AAV6VUV9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUV9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="231" mass="25476" checksum="8768D66F20DA7629" modified="2024-11-27" version="1">MMEKSKVAVDETSNVDYRSNDSSSIVSLPPAYDKPVSTTLKVARILSVTLLAVTTIIGVMVLLGIYIRQQQHCTCDNSRGEMVSASQVQPLSAARIDRMDHENTFTTDDKDAKKGKELSKPLKLELDAALGTILKDPKNKKAEVNCVAETRKASQVIHQDPKMLMTPFGNFTTDPKLVQVMGERMVMTCVSAVKQNKKTSKGRKLANKVAGLLPRPRRSLEKEMCSCNCDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVF0</accession>
    <name>A0AAV6VVF0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVF0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="157" mass="17411" checksum="C5901110B6B340E9" modified="2024-11-27" version="1">MQKVVKGITDDTPDCGDLLTDGKYPQDEDTKEDERQITNSEPYAGIEPVVTIKRDVEPLVDNGEGPKVEENGDNNNEPTAPNQNFVVDPPVVTLPPRIESAPLVREPLKEKETNGNVDNDPPNNKVSKGRDPIHQSSIVTRPIIHRDGEAQEQDGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVP8</accession>
    <name>A0AAV6VVP8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000016">
        <property type="protein sequence ID" value="KAG8200308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVP8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="10220" checksum="7F3970B7B87B8F44" modified="2024-11-27" version="1">MVNPRDPRDMHGIPQLRDESSCLYESWMRMEYIIILLPSLAAPFCYDGCSTSSRATLIQPNQNLASRKADETERNVINPHSPRHRYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VW93</accession>
    <name>A0AAV6VW93_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Selenocysteine lyase</fullName>
            <ecNumber evidence="10">4.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_006393</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.16" evidence="10"/>
    <dbReference type="EMBL" id="JAFNEN010000013">
        <property type="protein sequence ID" value="KAG8200812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VW93"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009000">
        <property type="term" value="F:selenocysteine lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000083">
        <property type="entry name" value="Selenocysteine lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000065">
        <property type="entry name" value="Selenocysteine lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF62">
        <property type="entry name" value="SELENOCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="2"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8200812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="397" mass="43569" checksum="C6441B41CC0C0707" modified="2024-11-27" version="1">MIYLDFNATTPIDSEVQKTICTSLNEAWGNPSSSYDTGKHAKSVIEDARRKVAEMIGSAPHEVIFTSGGTESNQMVISTACKNFHLEVESGLDLKIPHIITSQIEHDSIRIPLEKLVEERKAEVTFVSVCKSTGIINVDDIMKEIKPNTCLITLMLANNETGVIQPVQQLRPKLKVHKSASLCTILLHTDAAQALGKIEVDVDTLDIDYLTIVGHKFYGPRIGALYTKHMKPLYPLFWGGGQERNFRPGTENTPMIAGLGKAADLVTLNLEKYNQHMSAMCSYLVKVLKKCFKPKSVIVHFFKENRLPNTLSVAFDYECTGAAILAKAKNIGASTGSACHSGIGRPSEVLINSGIPADLAAKTIRLSVGRETTKEDINKAVKILHNAVKRVTFPLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWE7</accession>
    <name>A0AAV6VWE7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000019">
        <property type="protein sequence ID" value="KAG8200124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWE7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8297" checksum="5DC33537DD09B0E6" modified="2024-11-27" version="1">MCNSNKIKGSEIPCKSDGIIHLYLLSARQSSSSSSAQIDPGIAHTPVRIPMLLNNIMQPHRRRERQRLKGVETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXE8</accession>
    <name>A0AAV6VXE8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein-lysine N-trimethyltransferase SMYD5</fullName>
            <ecNumber evidence="2">2.1.1.359</ecNumber>
            <ecNumber evidence="10">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">SET and MYND domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">[histone H3]-lysine20 N-trimethyltransferase SMYD5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">[histone H4]-lysine36 N-trimethyltransferase SMYD5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_024319</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:54193"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="2"/>
    <dbReference type="EC" id="2.1.1.372" evidence="10"/>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXE8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10521">
        <property type="entry name" value="SET_SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044422">
        <property type="entry name" value="SMYD5_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="6"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8201449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="384" mass="43684" checksum="FF2BE1DBB13F3E54" modified="2024-11-27" version="1">MDDYLPSVEVRVIDEEKGKGLFALHKFDPGDVIFEERPLVCAQFLWNQAYGYLACDYCMKPLETAEENVRRLTGIQDLQLPYPECCSTRKDEYVECSYCEVSYCSPDCRDQAWEQYHQVLCTASLLGNTNHPLDELQDAWREMHYPPETASIMLIARMIATVKQAKDKAGAAHLFSQFCHKIKSSSGDMAHRLLGRQFQAQVEHLRQLIIKGLQDEDLLQWFTADGFKSLIALVGTNGQGIGTSAFGVWIKNCDSLEISEEEQEKLNAFIHNLYEKIEKETGPYLNNEGSGLFPLQSACNHSCVPNAEATFPYNNFTLVMEAIKEILPGEEIIVCYLDESNRNRSRHSRIKLLRENYLFTCTCAKCESQRCDGDFTSDSEADVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYW6</accession>
    <name>A0AAV6VYW6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYW6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="10138" checksum="C09795A264BE63A8" modified="2024-11-27" version="1">MTKKVSIRISVNIKVDSSELIASQMNSTTVFCFTMAYLNYFFLYHTTHTSTASKELEPDAKPSRAFSLTTKSNGRTELQERERHQKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCV8</accession>
    <name>A0AAV6TCV8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006925">
        <property type="protein sequence ID" value="KAG8155723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCV8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="7544" checksum="F2B17224CF13FB21" modified="2024-11-27" version="1">MTSEFPEVALTITEGGGGADSVSSASEAAKEKVNGDNSASGSEESSDSDSGSSSESDSEESESESAASEHEQRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TF03</accession>
    <name>A0AAV6TF03_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Araneomorphae</taxon>
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            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005903">
        <property type="protein sequence ID" value="KAG8158695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TF03"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8158695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14773" checksum="DA3EEFA2A1DB069F" modified="2024-11-27" version="1" fragment="single">DQPGILSNSLMFLRFRKKPFHHRGTPTIKGPLYLILPQKYCHKIKYETSHSRQTVLDSPRPALHIAAGRGNNKGRKGRQASRVGHAHGIQLTPTRSPMLRSQYAPYSHRNNFRDGAARHGGRTTRREAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TG27</accession>
    <name>A0AAV6TG27_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-C2HC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_019912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004931">
        <property type="protein sequence ID" value="KAG8170764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TG27"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006579">
        <property type="entry name" value="Pre_C2HC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07530">
        <property type="entry name" value="PRE_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00596">
        <property type="entry name" value="PRE_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-C2HC" evidence="3">
        <location>
            <begin position="332"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="469"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8170764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="512" mass="57244" checksum="C157C2B9B357540C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TG80</accession>
    <name>A0AAV6TG80_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005052">
        <property type="protein sequence ID" value="KAG8170677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TG80"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044011947" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="9703" checksum="5A26A2A765A9F99A" modified="2024-11-27" version="1">MGTVSVPLGFSWWITVSGPSLACFPTPFSLRVSGPVPCRSIAKLFRGNMVNIVSSIVRVGVSESRARGQLYSLVALFPFVVSPAAICSGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKJ5</accession>
    <name>A0AAV6TKJ5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002932">
        <property type="protein sequence ID" value="KAG8172243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKJ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="10175" checksum="079FDEC06E8B428D" modified="2024-11-27" version="1">MFSVKFLDLQSDTTDLMQGVCWSTPSCVQNNSSSPRHKLFRANCSVEYSIYIFMGREQHFQKALMLYWEVSDVNGQPMHPFPEAKGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNB1</accession>
    <name>A0AAV6TNB1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001956">
        <property type="protein sequence ID" value="KAG8173243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNB1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14625" checksum="22A528F8DA3CE474" modified="2024-11-27" version="1">MPNPIDYTEISNAQIDDIELKQLIENSEVLQFQKINLLDGKEPVYCDVSTGTARPYIPSLFGRRCLLPCMVYPTLAYASNGLIENFHRPMKAALKAYDTEEWSDALPTSAPGIPCGLQRRFAGDSSRDGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TP02</accession>
    <name>A0AAV6TP02_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_025374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001869">
        <property type="protein sequence ID" value="KAG8173339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TP02"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043043">
        <property type="term" value="P:peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000004">
        <property type="entry name" value="Elongation factor P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000009">
        <property type="entry name" value="Elongation factor P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="ELONGATION FACTOR P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053:SF12">
        <property type="entry name" value="ELONGATION FACTOR P (EF-P) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor P/YeiP central" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Elongation factor P C-terminal" evidence="1">
        <location>
            <begin position="60"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8173339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14523" checksum="EB716E3C724AE4FC" modified="2024-11-27" version="1">MRMLYKESDGVVFMDDESFEQFTIPLYILEDKQQWLLEEILYDVTFYKGQPIDVTPPTFMEMRVVETAPGARGDTASGRVLKPAITESGAKVQIPIFIEEGEKIKIDTRTGDYVALSKKDLFFIVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPJ0</accession>
    <name>A0AAV6TPJ0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001894">
        <property type="protein sequence ID" value="KAG8173300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPJ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10619" checksum="5BD668AF1C21F505" modified="2024-11-27" version="1">MKALDNDNSRIRRTSKSKEVKSCVAHFAYTFTGGFPRRISNIVEEEVDSLCQQMGGMDTESTSQERSRIERKKRLLNHLRDEKGRLEKKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQ89</accession>
    <name>A0AAV6TQ89_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_016184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001481">
        <property type="protein sequence ID" value="KAG8173808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQ89"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8173808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7979" checksum="FB492BEACE75765C" modified="2024-11-27" version="1">MFWIAYAMSWCRRQTTGSIEYLMENSVHSPAKFRVNGVLSNIKEFSEDFQCKLESPLNPKRKCFLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQD0</accession>
    <name>A0AAV6TQD0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001429">
        <property type="protein sequence ID" value="KAG8173916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQD0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8239" checksum="79F1EA2CA58D4809" modified="2024-11-27" version="1">MIDVFTRKAPGKTPKRTYLQPRRQSVLNGGFQDLGSIPKTPQTRNSSKNRVPVSILPPGNAVFPTTPFPPLAPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQW2</accession>
    <name>A0AAV6TQW2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001406">
        <property type="protein sequence ID" value="KAG8173949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQW2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="102" mass="11537" checksum="9981A76BFFF31C93" modified="2024-11-27" version="1">MVTESVVFINKIELLIIVYEGSLNRSPLVGFSRTSTARSSWCSACCAGTGSNPWSTQCFLLLMPVTSSFDFRAHRKLCDYKPFPWNCLLHFFLQVSTKKCCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TS78</accession>
    <name>A0AAV6TS78_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001118">
        <property type="protein sequence ID" value="KAG8174900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TS78"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="101" mass="10916" checksum="62AA26BDBE498E95" modified="2024-11-27" version="1">MSDISFESDSDIREPSPQSSVDPVPFSPSSNPIWTPSSPPAVFPPITQAPPDPTYNGTAVSPNITQAPPVSTYNGRPIAVVRPFQPCCPCTCRSTYYTRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSF3</accession>
    <name>A0AAV6TSF3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001190">
        <property type="protein sequence ID" value="KAG8174527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSF3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="345" mass="39804" checksum="EE29511A405848AA" modified="2024-11-27" version="1">MPLTLYIRGPTQYPITTFNLTEMLIRLRDGTEIRMQVQDQHVDVTLKNLPSNETMEQLLRRFGEEREPDVLYIDLGTIDAGAFCMQWLSSFVTENIGQIFNRMTPPHDPGPLQKQPDTHCNSLFLQPQEYRHTSSQDSMEPSHVVEASYASDTFLQHVWQKKGSAVVGSSNPRDDPTRLRASRTARAIGTRVEREETSAVTLEEQHCIERILGRDYVRQTDLVKLAGCVHKFARDEKDVWMLFAVDGLLGQDPKRYVDSLRCEEGPKAKHVRLVRKWYLEERVKHPAEMKEILEDVFQRGAGEKEYVEAVGEESVKQIVEWFEIRKKRAEGESSRKRSKTAVESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSL8</accession>
    <name>A0AAV6TSL8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Senescence-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_000074</name>
        <name evidence="1" type="ORF">JTE90_006436</name>
        <name evidence="4" type="ORF">JTE90_016102</name>
        <name evidence="2" type="ORF">JTE90_026870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006343">
        <property type="protein sequence ID" value="KAG8156073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010005971">
        <property type="protein sequence ID" value="KAG8157302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010002439">
        <property type="protein sequence ID" value="KAG8172707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010001227">
        <property type="protein sequence ID" value="KAG8174406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSL8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8156073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8157302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8172707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8174406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15009" checksum="F1C11E22B998122F" modified="2024-11-27" version="1">MIGRADIKGSKSNVAMNAWLPRASYPCGNSSDTSCIKLVKSKGLIGPAFAVRIHTENQDQASFCPFALREVSVLAELALGHLRYHLTDVPPQPNNPPESVLGADRALQGGSALGARSVILTGRFPLNRVSKETMKAVVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTS3</accession>
    <name>A0AAV6TTS3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001051">
        <property type="protein sequence ID" value="KAG8175163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTS3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11183" checksum="9447F22BAD952CDE" modified="2024-11-27" version="1">MELWKFRRQWREFPSEDNVGSFVANGENSPVKTTCSGAPADESRPRCRMPLPEPHATWKGAPLADESRPMTHAVARTACRLDRKKNLAFKETLVAEKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTV1</accession>
    <name>A0AAV6TTV1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_007782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010001123">
        <property type="protein sequence ID" value="KAG8174856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTV1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="53"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="494"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8174856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="585" mass="65288" checksum="45D39B4B3A0A3E50" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUJ1</accession>
    <name>A0AAV6TUJ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001036">
        <property type="protein sequence ID" value="KAG8175293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUJ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="46231" checksum="2C4F7143556E7DA2" modified="2024-11-27" version="1">MVSAVYPGKLTKISKKYNKKGNNLLKPILLLLMVFGFNLSNTKGTIFNAFFRFYSSLMVLLYHYFAVSDFVWYFQNPLDEIEIALADSITVWASVCTWDFLFWKRKELFRIVQIIERETEKLDGRHQKTYRRLVLISCTAAWLFVFVFMYISQFIVLPLDVKHDTYFVKSPFYFLPLHLFSRGQINLVIKIEKSLENFLIQGSLAMIVTLYVLLCLNIRMWFKKYGLSCKRNFRLASNLSIEDLKPFRLVLRQFSKRVTVVDNVFCIIVAVWLLMILVTLCVRTLAILHDEVQSNPQMMAMSVMEASRAILTLLSVGLAANGVYQESLLCLNVLEDVYYNPSWKESTYHEIASSRSMLQPAHLTVWKFAILNSSFLMTCIGAMITYMIIGVQLHTKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVY2</accession>
    <name>A0AAV6TVY2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000948">
        <property type="protein sequence ID" value="KAG8175836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVY2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20829" checksum="40B3DCE46264F165" modified="2024-11-27" version="1">MQNELERTEKEHYINILTYGCSAHILNLLAKDIKISNVKAQVVDVIKYFYNNHFASAKLREAGGKKLQLSSDIDNGIAKKITDFVLKCNSLEDYLLRIKPIVIACDTAQKDKCTISEVVEVWKTFKKKMEVCVNLSTRKQIERAVADRYKMEMSQAHSWQTLWIHALKVRHLQLMSMSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TW20</accession>
    <name>A0AAV6TW20_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_011276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000898">
        <property type="protein sequence ID" value="KAG8176292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TW20"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029602">
        <property type="entry name" value="IFT74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="448"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="603" mass="69317" checksum="1A31FC00297F177B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWQ2</accession>
    <name>A0AAV6TWQ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000888">
        <property type="protein sequence ID" value="KAG8176380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWQ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="132" mass="15030" checksum="4FAAE9EDC1307DB7" modified="2024-11-27" version="1">MLPRSPHQHSMRWNETNKGLLTQKFFPKVSTKRLILNRIAQIASGHGRFPAHLRRMQFDVDGECWCGLGPGSSEHYLTVCTLHDVEKLRLKLKAKDDFKSILLHKANQPVLNQIVLTVSKLLPSPLTRGLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TX18</accession>
    <name>A0AAV6TX18_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000928">
        <property type="protein sequence ID" value="KAG8176012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TX18"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF3">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043697777" evidence="1">
        <location>
            <begin position="22"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="272" mass="31894" checksum="5ECE64A5CE0E7F5C" modified="2024-11-27" version="1">MCRYWDTFLHLVNLLKFLVAADRNGDWDSHLQAIQNLLPVFREFDSINYLRYASWYLEKMRCLEEKHPEVYHKFKAGNFVVRQTKRPFTAVSPDLKLEQTIQRSQKSSNGIIGQTRQQMYVTEYELVYHEVLGISNRFREILGADSSGYSEVIVHHELSGNLNANMLKHINILFEFMNTRGNPYESSIQTLLHNFINSKCVPREDAVRLLKVKEHGSEAYEPFRNDRFVNKTLKLSDVIRKIRLPTMERKIIIPTVKSQTAQATQKKEYCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TX84</accession>
    <name>A0AAV6TX84_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000862">
        <property type="protein sequence ID" value="KAG8176632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TX84"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="14244" checksum="4847204096A8B1F1" modified="2024-11-27" version="1">MKKTNPSSIHSTFPLKTSSQVKVIVKQVINQLIPPRQQLVPSSRQREETRKPVIKFPFPEVYTAMTSDETFSYADLCKMPQQEQVPCRKAMQDEINAMEEYKVWNLQFPPPNVKPISCKWIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXM7</accession>
    <name>A0AAV6TXM7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000918">
        <property type="protein sequence ID" value="KAG8176079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXM7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="143" mass="16099" checksum="C88101CFA7F48A40" modified="2024-11-27" version="1">MKLPFSVILDGIRDTISSSGLERSQLLTNKDLHNIEHSFNVGSEAKGHPNDGTSVETWVNEINADPDSCVLLYKPQGVTCSNFPLLKSEDFAQNQYWLLMSIRDNEASEEVDKIAPSDEQGYDEQSEMERRVADVLDSIQTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYJ5</accession>
    <name>A0AAV6TYJ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_018716</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000840">
        <property type="protein sequence ID" value="KAG8176933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYJ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8176933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60878" checksum="E3B73FF7FEA1F7EE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYZ6</accession>
    <name>A0AAV6TYZ6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_018333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000787">
        <property type="protein sequence ID" value="KAG8177307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynamin"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="3">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8177307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="386" mass="44004" checksum="3AB0A39D082362E9" modified="2024-11-27" version="1">MPEKNRFTSKPIPLKIYSRRALKLTLVDLPGIVKVAVAGQPDSNVREVQSMVLSYIRPKECIILAVMPANQDLATSDALEIAALVDPERTRTIGVLTKPDLMDQGTDACEILKNKQVVLKRGYLVVLNRNLMDITAGRDIPHGLEQERIFFESRECYREWRHRCGIPNLQKELQLTLRQHIKDALPEVRNKLAQKLYASNQQLKAIKQKIGGGPNNRKLYMVKLINSFITDLKIKLLGHSELIDSTSLSPGVLINYKLYGEVQQKLNLRLVPDIEELTILLTNVKGFKESVSLSTLALDAMCRKLMSEFDTPMEQSVFCVQRILLQTIEESATKLDQYPSTKNEILFRIRRSVDQATSQTLERLQEHVKAEMFFVNIKHPDMDLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U111</accession>
    <name>A0AAV6U111_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000778">
        <property type="protein sequence ID" value="KAG8177497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U111"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="9075" checksum="38E225DF856C79BF" modified="2024-11-27" version="1">MASSSMTPKNGNAKRFKPTPAETLHEDLDFDFDCSGPLFKEPETPLKKLKPAYDLDLAQDEPQKRRISPYAINIGPRSKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U435</accession>
    <name>A0AAV6U435_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microtubule-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000662">
        <property type="protein sequence ID" value="KAG8178859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001084">
        <property type="entry name" value="MAP_tubulin-bd_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00418">
        <property type="entry name" value="Tubulin-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51491">
        <property type="entry name" value="TAU_MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
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            <end position="323"/>
        </location>
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            <end position="356"/>
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            <end position="386"/>
        </location>
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        <location>
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            <end position="453"/>
        </location>
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        <location>
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            <end position="485"/>
        </location>
    </feature>
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        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
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        <location>
            <begin position="534"/>
            <end position="558"/>
        </location>
    </feature>
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        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
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        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="754"/>
        </location>
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        <location>
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            <end position="800"/>
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            <end position="826"/>
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            <end position="888"/>
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            <end position="1025"/>
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            <end position="1050"/>
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            <end position="1063"/>
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        <location>
            <begin position="1064"/>
            <end position="1075"/>
        </location>
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            <end position="1096"/>
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        <location>
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            <end position="1170"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAG8178859.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1309" mass="140976" checksum="48D121682CE3C006" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U608</accession>
    <name>A0AAV6U608_9ARAC</name>
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        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_021986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000637">
        <property type="protein sequence ID" value="KAG8179318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U608"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043641725" description="C-type lectin domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="42"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="192"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="335"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8179318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="536" mass="61518" checksum="62FD3A9FECDABD40" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U686</accession>
    <name>A0AAV6U686_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_025979</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
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            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000601">
        <property type="protein sequence ID" value="KAG8179812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13389">
        <property type="entry name" value="PH1_FGD5_FGD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13237">
        <property type="entry name" value="PH2_FGD5_FGD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF267">
        <property type="entry name" value="PROTEIN CBG10230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="2150"/>
            <end position="2339"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="2368"/>
            <end position="2462"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="2504"/>
            <end position="2564"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="2615"/>
            <end position="2712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="187"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="720"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="762"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="971"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1098"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1340"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1422"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1647"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1902"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2009"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2077"/>
            <end position="2134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="310"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="331"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="504"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="547"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="773"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="801"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="835"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="879"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="908"/>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="1457"/>
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        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1551"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
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        </location>
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        <location>
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        <location>
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            <begin position="1783"/>
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        <location>
            <begin position="1835"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1931"/>
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        <location>
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        <location>
            <begin position="2107"/>
            <end position="2124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8179812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2714" mass="302363" checksum="81E66B0D685D40F4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6K1</accession>
    <name>A0AAV6U6K1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_025752</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000621">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6K1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31705:SF4">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8179523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6V6</accession>
    <name>A0AAV6U6V6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000627">
        <property type="protein sequence ID" value="KAG8179401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6V6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="9153" checksum="FC9E41BC511AE0DE" modified="2024-11-27" version="1" fragment="single">MAAIRNARHDPDSESPIDYVQIDGLVVLKIIKHCHEEGGWVFLMWPREFCLDWVWTTDWKSQTASHIQGTPMRKTLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U722</accession>
    <name>A0AAV6U722_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000586">
        <property type="protein sequence ID" value="KAG8180112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U722"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9288" checksum="2F4850D38D9A7631" modified="2024-11-27" version="1">MDAAQPILAIVLDVPSPGLAFDVYEHSGHRFLEMDEHKRRKIAVEIGEREVVFGNGPVCWVVANWADVFSVGRILKETGVVSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U743</accession>
    <name>A0AAV6U743_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000582">
        <property type="protein sequence ID" value="KAG8180142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U743"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="9009" checksum="22C39E0D9A01142E" modified="2024-11-27" version="1">MRLKCEHMMKYENTTYSEVSTSRLDRSFLAERTLLLTSSYLMPGAKELLRLLPFLLKKERAEPQCFISIDFPRFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7A3</accession>
    <name>A0AAV6U7A3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000596">
        <property type="protein sequence ID" value="KAG8179942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7A3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026698">
        <property type="entry name" value="UPF_C3orf38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21084">
        <property type="entry name" value="DENSE INCISORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21084:SF1">
        <property type="entry name" value="DENSE INCISORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15008">
        <property type="entry name" value="DUF4518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="276" mass="31535" checksum="40640B9CF68E20D4" modified="2024-11-27" version="1">MLTPKEQAGLRDILDDLSDIDLFSIAKTVTKNLLSTKSRYDAVEAILKCLEKPSDLLKRQRVTKRVLFSYLLKVKSLVSPECSKTELVMMCLEEWKSTGNDTTTNYDRCCHPDVPNHTNNWLDVMGCQFSEWFFSHYNSLKDFGPEHFWVDCRMRGELNIASNQQQAEVIGANKVVSFLSSLIVNDRFFFHANNSQDSIICEQDPHGLVKIIISGVVHQDSNCIGLFDSAFGLVRNPNYDNNWKIKWIQLKINVTGGRREHVMPVNEGLKSICQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U889</accession>
    <name>A0AAV6U889_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000600">
        <property type="protein sequence ID" value="KAG8179825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U889"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="95" mass="10604" checksum="989BB22DEB522AB8" modified="2024-11-27" version="1">MGSINNANWVICRLGKGDWTFGKVEKNNQKSVLVNCIPIAVSHQITAHWRNWRRTPHCNPNSLNDGRPVYLNGQPPPPPPPGVNFDSPPPLTRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8M3</accession>
    <name>A0AAV6U8M3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000577">
        <property type="protein sequence ID" value="KAG8180203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8M3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="11184" checksum="1F4445DCBDA31E43" modified="2024-11-27" version="1">MDANFGEVNSSGNQYPPSIASSLRSAFVSRRYSSSTNPTNDFMWIDRNGRPVSPPSNHPRSPTFRKASMRHTKQPRDIRESRAFFAKAITVAFYTGGDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9U7</accession>
    <name>A0AAV6U9U7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000539">
        <property type="protein sequence ID" value="KAG8180989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9U7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="85" mass="10172" checksum="7A51DA79C3791649" modified="2024-11-27" version="1">MLFRFNISGGHKGKVNMLETAYSNIVDKAVSAMMDKENERDRKQDEKFETFRQNFLHIREETFHSQKEHCSKIEDFLKQLKGYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAS6</accession>
    <name>A0AAV6UAS6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_009824</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000502">
        <property type="protein sequence ID" value="KAG8181662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAS6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15927">
        <property type="entry name" value="7tmA_Bombesin_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001556">
        <property type="entry name" value="Bombsn_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF26">
        <property type="entry name" value="NEUROPEPTIDE CCHAMIDE-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00358">
        <property type="entry name" value="BOMBESINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="75"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8181662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="389" mass="44842" checksum="B5BCD18448C0499B" modified="2024-11-27" version="1">MSLTQENNLSLEDTCMSCPSVLPFANNISDLVLSIDNQLDDNATNITDYVPYEKRLETYLVPAVFAIVFIVGLLGNGTLIFIFMRHKTMRTIPNTYIMSLAVGDFILIVGTVPFISTIYTFESWPYGEYICKLSEFLKDVSMGVTVFTLSMLSYDRYIAIVLPIKKHTGSSAKTLTIVIAIGIWMMSVVLALPGTYFSFLWEYPVTKDQVIYICYPFPKHMMPWYPRVVILSKFLLLYGIPLILIGSFYAMIAWHLITSSRNNIGQNPSHMKQLRSRTKVAKIVLAFVVIFAICFFPSHTFLIWYYFDSNPNEHYNHFWHSLKIIGYVLTFANSCLNPIALYLISSVFRNHFKRYLFRCCCKPEELRRETMTHSTSYRNAHHDGTIKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCZ1</accession>
    <name>A0AAV6UCZ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-latrotoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_000041</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Homotetramer in membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cationic peptide 01 (latrotoxin) family. 03 (alpha-latrotoxin) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000487">
        <property type="protein sequence ID" value="KAG8181930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCZ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="12" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8181930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="340" mass="38622" checksum="EB642E7E23AC7830" modified="2024-11-27" version="1">MADFTSIHDILDKPGYTYEQIQTLLRRDPSSINQVLGGKAPLHRVLKGPSRGPASIVKLLLEYGANPNLRDYKQRSPLLMTVMRRDRLEVVRELVEAGARIQPRSELPLCTLRVFLDFQAEVGLVEMLIQAGADFNIDTSYERTPVYSAFQYKDKDDVERVKALLDSSGVDLKIRNPWNATLLHECITWAHEPPLDFIEYLLDRGLDVDAVDDFGMTPMHEAAKRGWPTVVNLLLKRGASLYRRNNEGETPLSIAVSYRHGFHLIKLLLNCGAKVCPLALTNALENYNNQKTLETFETFLLLVKFCYLQYMDFAVSCVVRGHFLQDTLLNFGKRANTSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDN8</accession>
    <name>A0AAV6UDN8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000493">
        <property type="protein sequence ID" value="KAG8181858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDN8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="149" mass="17091" checksum="2B65592351DD028D" modified="2024-11-27" version="1">MSKFIYPNTTPIILLDCQNAFKDLTEKEKLYAHYLSRASWYGGLIDVVQNSPESPLIFSLLHRLFLTDSVKDLKETALTKCGFSEEEFLAFLIYACGVFFNCANYKSSGHSKFIPDLSKEKLLKNIECFLPKSLQRKKFSPKKLFETVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDW9</accession>
    <name>A0AAV6UDW9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_023559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000517">
        <property type="protein sequence ID" value="KAG8181396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDW9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043417331" evidence="4">
        <location>
            <begin position="26"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8181396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="383" mass="39967" checksum="246D8B82BC62AE84" modified="2024-11-27" version="1">MDSPRLSLILIFLCCTFLLCQEASCYNILRLNRSPEDNFKIRERRGIVEDTANFFQGITNIGVSIARKGLSQLPFIRRVFEEPSTEIPPNKAPTNPDVEPNSKGVIGSVVSTVRRELSLLPFIGGFFEEPTTEAPPTQPTTQPSGEPNKQPASEFTSQPSGELTTQPAGEPKTQPSGSEPTTQPSGSEPTTQPVGESTTQSSGKLNTQTTGGEPTKQPASESTSQPSGGERSTQPSGGELTSQPAGESTTQPAGGEATTQPSGGEPSTQPAGGEPTTQPSGGERSTQPAGEPTTQPSGGGPTTVPAGEPTTQPAGELTTEPSDGERSTQPSGGELTSQPAGESTTKSSGGESSGQEMNLQYFVLEIICTIYLFLCLCLLSVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEB2</accession>
    <name>A0AAV6UEB2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000463">
        <property type="protein sequence ID" value="KAG8182425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEB2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="599" mass="67021" checksum="7CB184F1C09607C5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEB9</accession>
    <name>A0AAV6UEB9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_000439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000445">
        <property type="protein sequence ID" value="KAG8182832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEB9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF652">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="291"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8182832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="706" mass="78274" checksum="7BFFE35F419D0536" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF74</accession>
    <name>A0AAV6UF74_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000431">
        <property type="protein sequence ID" value="KAG8183117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF74"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF16">
        <property type="entry name" value="CBP80_20-DEPENDENT TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="301" mass="34027" checksum="14DBEAFBE11B5AF2" modified="2024-11-27" version="1">MPIYCFYSTENFFSACQVPLRIIFLHQKMATKARGRGYALSKNAQSGELRRPGETSMGISNASKINGKEPVLSKSPEDNIEKICNTMAAIDLSLPQSALETFAGELKAVCKTSELLEKCAENLFQFALKSKWNAHAVAVFCNFHGEITVEQVKLRNLFFKKLQGRYLERSKAYQELDKFLLDATFACEVFHHVRIAGAHLKVLSGPVLDYFGMLLTGASQKEVEVVMEQFPKCYKNIKDCDGFDDLLTKLRKQIISETTTVTVKAMMLELFELILTDWKVMNPSAKTFYETLSKPIVRICD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFV9</accession>
    <name>A0AAV6UFV9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_026162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000451">
        <property type="protein sequence ID" value="KAG8182708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFV9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8182708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="186" mass="20534" checksum="7B0DC03E9D123EBB" modified="2024-11-27" version="1">MNLMPVGAKDTSELPCQHRHGTLTSPDSFQEYAIIIALGVNLPIPVVVHISVHSKSYNNRTQHAKQTVHSVRVRPENFIFFLLRHLSEVSVKKDRDPMNLQPGGAEDTTASPTITVHSTPNRPYIRFVYVLKTSSSSFCVICLTKPGPLSEVSAQKDRDLVNLRPDGAEDTGGPVSTDMDLDRLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFX4</accession>
    <name>A0AAV6UFX4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxidative stress-responsive serine-rich protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Oxidative stress-responsive protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Peroxide-inducible transcript 1 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_017094</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000436">
        <property type="protein sequence ID" value="KAG8183006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFX4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008494">
        <property type="entry name" value="DUF776"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31383">
        <property type="entry name" value="OXIDATIVE STRESS-RESPONSE SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31383:SF2">
        <property type="entry name" value="OXIDATIVE STRESS-RESPONSIVE SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043708979" description="Oxidative stress-responsive serine-rich protein 1" evidence="5">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8183006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="181" mass="20428" checksum="90215D1EA4D76ADC" modified="2024-11-27" version="1">MGHVLGSRLFLSLCIEMAGAEDCQLTDLQSEFKKLRVDFNNLCQQKPVDECCHKPPNKEQDASPNFLSSPRSEHCKCNIRAATSGSRLLSRKKKKRCHKKKQTLEKNSGSEGDLFMLNEILQAVKQTQNCSGESVLDHRIGIEDTGNDHSDDTTVDELAGYFDNLVYIPKKMSHMAEMMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHP3</accession>
    <name>A0AAV6UHP3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000413">
        <property type="protein sequence ID" value="KAG8183617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHP3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="302" mass="33030" checksum="955A1430E4192884" modified="2024-11-27" version="1">MNSAPSCRLLYKPRVLQSVGSTSSLSQDSYIFKDGLSDISSDSHNMHKDPPPELLYPSPPPSSITTTTLLLTPDDFTASPSHQTAAPGSNAEHLPVVSTEAVPQRRKSSQHSGASSPSREVAEILAPNKELLHLDEMEQENVTPSKDAEIESVSNNLGSFSANSGTSRNSQDYNLKEWPQAPDPTKDYRLASRTENDMQSLTQHFQRTSGDVAEPSFQNDLNIQVPAFSQNLDSMGHKLDSIVQFLRAQHQEIQALQNEIKVLRQDHKTNQQPAQKDQSVSNLGAAHNAECGAAPYPFAGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI02</accession>
    <name>A0AAV6UI02_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">JTE90_006475</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Endosome lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <location evidence="18">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000425">
        <property type="protein sequence ID" value="KAG8183281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031904">
        <property type="term" value="C:endosome lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000155">
        <property type="entry name" value="Low-density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000189">
        <property type="entry name" value="low-density lipoprotein receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000024">
        <property type="entry name" value="Low-density lipoprotein RecePtor related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000181">
        <property type="entry name" value="Low-density lipoprotein RecePtor related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000002">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000011">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000005">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000035">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000045">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000078">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000121">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000113">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000037">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056588">
        <property type="entry name" value="EGF_LRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032485">
        <property type="entry name" value="LRP1-like_beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16472">
        <property type="entry name" value="DUF5050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24468">
        <property type="entry name" value="EGF_LRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="35"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI17</accession>
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        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1270" mass="149365" checksum="AEAD7DEF615A9B4F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI25</accession>
    <name>A0AAV6UI25_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_002404</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000406">
        <property type="protein sequence ID" value="KAG8183767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097254">
        <property type="term" value="P:renal tubular secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017085">
        <property type="term" value="P:response to insecticide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000205">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000121">
        <property type="entry name" value="ABC transporter B family member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000018">
        <property type="entry name" value="ATP-binding cassette subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="854"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="898"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="977"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1001"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="187"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="530"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="858"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="1179"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8183767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1420" mass="155979" checksum="25549759A58645B8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIR1</accession>
    <name>A0AAV6UIR1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 4E binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_008989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF4E-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000378">
        <property type="protein sequence ID" value="KAG8184305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIR1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008606">
        <property type="entry name" value="EIF4EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669:SF12">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05456">
        <property type="entry name" value="eIF_4EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8184305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12788" checksum="2B0DBDD5DFFEA2F0" modified="2024-11-27" version="1">MNSNEAQRKISSNREIPGRRVVIHDASQLPIDYSSTPGGTIFSTTPGGTRIIYDRAFLMQMRNSPIARTPPKNLPNIPGITSPNHSKPKENGTEQTEDKHGEPEHHEDPLFSMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKF0</accession>
    <name>A0AAV6UKF0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_013079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000364">
        <property type="protein sequence ID" value="KAG8184686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKF0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="378"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8184686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="562" mass="61195" checksum="C2AD76CA3F10613A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULQ0</accession>
    <name>A0AAV6ULQ0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000367">
        <property type="protein sequence ID" value="KAG8184644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULQ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="117" mass="13395" checksum="94EACE45DB5D2BFE" modified="2024-11-27" version="1">MFCGHIITSYEERMKTVFSVCTFKFRETILKTCNTRSELWDVHARILSAIDLPAAEARYHQVRSGNFRNDKPIPAKYGDSRSLPSSVGRPVDNDCSEAFVKTCTWFQENCQEPISVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNN5</accession>
    <name>A0AAV6UNN5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L27 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000325">
        <property type="protein sequence ID" value="KAG8185774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNN5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.470:FF:000001">
        <property type="entry name" value="Disks large 1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.470">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015143">
        <property type="entry name" value="L27_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09058">
        <property type="entry name" value="L27_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L27" evidence="1">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="128" mass="14722" checksum="2FAE146837E4A706" modified="2024-11-27" version="1">MDVRSIPRLNDQEAHRALELLEEYHAKLVRPQDKQLRNAIERVIRIFKGRLFQALLDIQEFYEITLLDESKSIQQKTAETLQIACKWENSPPLSGLSYLNEVSVLPLPIPPTHEQAYAQVIALFLGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URN8</accession>
    <name>A0AAV6URN8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_009238</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMTC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6"/>
    <dbReference type="EMBL" id="JAFNEN010000300">
        <property type="protein sequence ID" value="KAG8186483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URN8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44395">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44395:SF1">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 16" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="18">
        <location>
            <begin position="259"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="447"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="565"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="599"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="670"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8186483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="855" mass="96822" checksum="09CCDBB6F8E99214" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URS4</accession>
    <name>A0AAV6URS4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">MAP/microtubule affinity-regulating kinase 3</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Serine/threonine-protein kinase par-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">JTE90_007329</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with MAPT/TAU. Interacts with DLG5 (via coiled-coil domain). Interacts with STK3/MST2 and STK4/MST1 in the presence of DLG5. Interacts with YWHAB, YWHAG, YWHAQ and YWHAZ. Interacts with PKP2 (via N-terminus). Interacts with CDC25C. Interacts with KSR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000306">
        <property type="protein sequence ID" value="KAG8186305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URS4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12196">
        <property type="entry name" value="MARK1-3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14072">
        <property type="entry name" value="STKc_MARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14337">
        <property type="entry name" value="UBA_MARK_Par1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001032">
        <property type="entry name" value="KP78b, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000001">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049508">
        <property type="entry name" value="MARK1-4_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="82"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="25">
        <location>
            <begin position="352"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="26">
        <location>
            <begin position="750"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="398"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="481"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="511"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00054424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00063680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00074935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAG8186305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="799" mass="89375" checksum="140670CAA91DB1B8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URY7</accession>
    <name>A0AAV6URY7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000305">
        <property type="protein sequence ID" value="KAG8186326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URY7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7851" checksum="609426833AEB9323" modified="2024-11-27" version="1">MLFRCGYILNGENPEHGQGVSSSARVRAFQASYSSYAHHIAHRKGYHTAANHAGHMQSRRIQHARSQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6US41</accession>
    <name>A0AAV6US41_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000281">
        <property type="protein sequence ID" value="KAG8187019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6US41"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="116" mass="12841" checksum="94A073084BC2A5F3" modified="2024-11-27" version="1">MDGRSKGHEPTKLYPSKPTILRRLLPLLERGRRRRCRRNRAKHSATGEREGDVHPCAGSKADSKEKSNEVSELEEDDDPGIGRGGTTRRRFQAESVHLGAFPAASFASTSTLVWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USL7</accession>
    <name>A0AAV6USL7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General transcription factor IIH subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_020864</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000297">
        <property type="protein sequence ID" value="KAG8186566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USL7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000115">
        <property type="entry name" value="General transcription factor IIH subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="12">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="BSD" evidence="12">
        <location>
            <begin position="183"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="318"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8186566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="553" mass="62777" checksum="FBE4EAB8283EE693" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU23</accession>
    <name>A0AAV6UU23_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_004890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. NFIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000278">
        <property type="protein sequence ID" value="KAG8187148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU23"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14694">
        <property type="entry name" value="bZIP_NFIL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000025">
        <property type="entry name" value="nuclear factor interleukin-3-regulated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047229">
        <property type="entry name" value="NFIL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047106">
        <property type="entry name" value="NFIL3-like_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284:SF0">
        <property type="entry name" value="GH23983P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284">
        <property type="entry name" value="NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="109"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8187148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="436" mass="48409" checksum="7463F6535AD648DD" modified="2024-11-27" version="1">MMITSTDHPSSSSSKQLTPFRYSDVPPSPQSPPSYQSHALYSPLSPQAGSMSPNPYPPMSSGGWNTNPASEAPVDLTAALNKGGHHQGGGKDIFPARKQREFIPDSKKDDSYWDRRRRNNEAAKRSREKRRLNDMVLETRMLELSKENAMLRAELVALRDKFSLPQSGGMEGGQLHLHIPQPRKMSAPESPPHDSSRVMPHLRIMDPQQWQEVHALKEQAHHLQMMQQQHLHQQVIQRLATHHHHHPGSMEPHPLHGAPPPRSTSPPHPADETCSWSSADEPVSHVSLQHCLPLKLRHKTMMSNDAPPLLPYVVPVSSSDSGRSTDTASSDGDSKEEPSSPRHHDDEGAAPPRKMARLSRRSKGASSDLAAENYHLRFELKKLASEVAGLKDMLLCNRTSPPAPDMMGTTTPPLSNRTSPNIVEEQAQQQASEQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU78</accession>
    <name>A0AAV6UU78_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000288">
        <property type="protein sequence ID" value="KAG8186811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU78"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8467" checksum="67578978863A4B84" modified="2024-11-27" version="1">MSARTDAVTTSSPTHMRRRLQKSQDLAVDASMTCYFITHAQRTTKKAIFEMCSLEMSLYITTYAQMAHDLRCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVC9</accession>
    <name>A0AAV6UVC9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein regulatory complex protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IQ domain-containing protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_007998</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRC9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVC9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23766">
        <property type="entry name" value="IQCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042618">
        <property type="entry name" value="IQCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="179"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8188430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="329" mass="39296" checksum="9EE2FE52BFCD35EB" modified="2024-11-27" version="1">MNSKKLKSNDVKIILGILRRLEERLYLLRVSICDTEGIKSLKDRLLQIYSDSDFGDKTELLPQLECKERNVVLDCCDIEIALGNVLHELTQRGTFKSLFEFVQDKEGIYENFGKRQNLLNTKREQVEELKRQLSTLGKQSNSTVLLQQDKSIFSVRETNSEENISYLKQLLKERIKSKKEYYEHLFKEINEKREELQREVEMQNHANIQIFSSSLLRFEEQVESLDEELRKTFDDLAMKKREVAVLKKYKRFNLEKLEMVTKEISIRKEVIEKDKHEKEMERQRLEEERKKNNAATLIQAQWRGTMVRKYLGPFKKLKKKKRKKGKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UW96</accession>
    <name>A0AAV6UW96_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000235">
        <property type="protein sequence ID" value="KAG8188590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UW96"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="112" mass="12810" checksum="E5FD9BB580375CA5" modified="2024-11-27" version="1">MPKSAMPSSNLRSTFVIVTDHKALPTPRLLAAHRRKTERDFELPYATSKKHLEPANEKYVQTAQRRCHAIRLQGFEIRLCGGDTIDCPRNLVEEGPSPDTVKDWRSPNKTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWL3</accession>
    <name>A0AAV6UWL3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_007185</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000236">
        <property type="protein sequence ID" value="KAG8188579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWL3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043865677" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="28"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8188579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="214" mass="24822" checksum="22A94BDABB014EFA" modified="2024-11-27" version="1">MLRSIFCIFLSYLSLSSALYFHIAETERKCFIEEIPDETLVVGNYKCELSDPKTGGFMPSSAGIGMHVEIRDPDEKLILSKVYSSEGKFTFTSSIPGEHVICLYSNTTKWFSGSQLRVHLDIQVGEHAVDYGNVAQKEKLTELQLRLRQLLDQVEQISKEQNYQRYREERFRLTSESTNQRVLYWSISQSAILLVMGFWQMRHLKSFFQAKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWN5</accession>
    <name>A0AAV6UWN5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000246">
        <property type="protein sequence ID" value="KAG8188208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWN5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="7303" checksum="19EA60DD06052C33" modified="2024-11-27" version="1">MRSICSLTAGQALGDPDGGDVARDGPAAGVQAVPPVPPYRQLLAGGAQDELERQGPAAETVGVQPCCEDICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYN4</accession>
    <name>A0AAV6UYN4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000235">
        <property type="protein sequence ID" value="KAG8188630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYN4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="408" mass="45540" checksum="D2272236EFC89954" modified="2024-11-27" version="1">MLLGARPCANATFARLSSCSNVYKTSAVKISFQTKARSKLHVDIAFDQNSTPRLSLSRSLQHRSRKVSIELSNKNPFRHFRDNAHAQLLAVAEISCESFWEVSGVMKELKMFPQITEETEENLLHLEDEEEDPPKSPPPTYCHPSTPSKQNSTSSSDSPPNSPNDDTQPPCPLLTITNDDTDQPNTTTNHIVHQSTSLDEGCTTPPPTRVRMRSLSGGAYRLTPLPATGRMRRVSGDDVLTRVSPSRRSTIFEQFRPRSKSDSKGKRPTFLSNLKNTFFSGAQRKNSLETEPPLLEQLQPVGDYRQRSGSETRGGTMSKMIDLFRNRSNSLSTDSRGKKPSNSYVPTNSLLRRHSVDPDKRRRPCYNAYRSLDTHQGDSCHGEEDASGAAKTPNHLRKPKRSTDVTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYW1</accession>
    <name>A0AAV6UYW1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_020241</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000216">
        <property type="protein sequence ID" value="KAG8189427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYW1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="106"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8189427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="568" mass="64684" checksum="47F0705C447EC2AF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZ27</accession>
    <name>A0AAV6UZ27_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000211">
        <property type="protein sequence ID" value="KAG8189591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZ27"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14809">
        <property type="entry name" value="bZIP_AUREO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039165">
        <property type="entry name" value="CREBRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21552">
        <property type="entry name" value="ADULT RETINA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21552:SF2">
        <property type="entry name" value="CREB3 REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8189591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="597" mass="67060" checksum="479C3FF83B56D4B7" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V302</accession>
    <name>A0AAV6V302_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000185">
        <property type="protein sequence ID" value="KAG8190408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V302"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="228" mass="25291" checksum="18DD0B2727468AB9" modified="2024-11-27" version="1">MVQPLFGEVQMHRLKNGIEMCNIIHNRLTGRSGGLANLGVSPPTHPRDCEIRLFKHCVLRTLLEQHLILIGTIACEVGLNDESCATLPYERKCEQGPPPVWKILEETNALVCRGRAFSEARDAQSADRREMAVADKILKASWEMMQMNTYFGAPIRRFAQPLRAVDIPDISVPEIPLADKNRSTSLSTRVTASTFYCPNSVSPLPTHGCAYLGPYLHSGVLLKGVIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V609</accession>
    <name>A0AAV6V609_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000144">
        <property type="protein sequence ID" value="KAG8192134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V609"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9549" checksum="78579FB0239AA3F2" modified="2024-11-27" version="1">MSNSRATPDIAINIQAVHDVLKEKYKGPVNPSASVYLAAVLQSIAVELIEAGGRKGADSDGNAPSTITKTMIQQAIEGDEELDRVFTTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8B6</accession>
    <name>A0AAV6V8B6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Glutamate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">JTE90_022834</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="21">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000151">
        <property type="protein sequence ID" value="KAG8191846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000043">
        <property type="entry name" value="Glutamate synthase 1 [NADH] chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
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        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
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        <property type="entry name" value="FAD/NAD-binding_dom"/>
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        <property type="entry name" value="GATase_2_dom"/>
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    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
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    <dbReference type="InterPro" id="IPR036485">
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    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
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        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK11750.1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
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        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17 21" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="16" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="22">
        <location>
            <begin position="22"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="23">
        <location>
            <begin position="1580"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="20">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1130"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
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    <feature type="binding site" evidence="21">
        <location>
            <position position="1136"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1141"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048151"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8191846.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2035" mass="225474" checksum="F94421938A389479" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8X3</accession>
    <name>A0AAV6V8X3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_017182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
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        </lineage>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000137">
        <property type="protein sequence ID" value="KAG8192617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043709004" evidence="2">
        <location>
            <begin position="23"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
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        <location>
            <begin position="102"/>
            <end position="327"/>
        </location>
    </feature>
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        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
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        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
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            <begin position="216"/>
            <end position="290"/>
        </location>
    </feature>
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        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8192617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="365" mass="41655" checksum="3EA7DFE42886C429" modified="2024-11-27" version="1">MKLNRFTHLLFFVLVLACHSHASDEGVSPTETPPHHTRSLLFFPIFPVPKPISIFSKPPPQKDDDQPKQSGGGLIGNVLQGGSIGIEIRPLAPFQGVIDHAKKILPGGGGGHGTVGRPSHERPGHHERPHHKPEPGDEGPYEPEDEKPHHPQPGYQRPHNQRPGYERPHPQRPGYQRPHEQRPGFERPHEPEPGHDRPHQERPGYERPHPQQPGYERPHPQRPGNERPHPQRPGYERPHPQRPGNERPHPQRPGYERPHPQRPGYERPEPEIPHPDNEKPQPELPKKDENEPLTEEVPGWEDIGEGGGDDEYGDGILMPRKKEKRPKRFVDSRIYHVPLKYVSNGRTHRVRRIRNGLADIMAKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8Y1</accession>
    <name>A0AAV6V8Y1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">JTE90_006993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000128">
        <property type="protein sequence ID" value="KAG8193165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8Y1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="154" mass="17137" checksum="337679C41D2516A1" modified="2024-11-27" version="1">MELIWIAVLLIGVFGGIAFGVMLYCIFHRMQKHYHPQIIEHSQSWQFGVTNLSFIGDDQVSSFADPSPDYSTVMSRNVSSDQNRTRGFFSRFLKRSPGGMNSNGSTAASGMEEPPPSYSSVVPHTDVDFFVRCQAVDDVILFIKMTDCPKSGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBF1</accession>
    <name>A0AAV6VBF1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">REST corepressor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_012190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CoREST family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000123">
        <property type="protein sequence ID" value="KAG8193388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBF1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000033">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REST corepressor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049048">
        <property type="entry name" value="REST_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051066">
        <property type="entry name" value="Trans_reg/Corepressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089:SF28">
        <property type="entry name" value="REST COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089">
        <property type="entry name" value="REST COREPRESSOR COREST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20878">
        <property type="entry name" value="REST_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ELM2" evidence="10">
        <location>
            <begin position="38"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="123"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="343"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8193388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="57108" checksum="D7701A85F7970630" modified="2024-11-27" version="1">MVLADRVMQDRGGGRRSRAASPITPNSDESSNTDDSEYSMKVGIEYQAVIPDLISEGPCPASEPENALLVWAPCSNIDEDKMDKFIHEAKEKCGYNVEQALGMLFWHKYDLEKATADLYNYTPFPDEWSVEDKVLFEQGFQFHGKVFNRIRQMLPDKPLSSLIKYYYLWKKARARTSLMDRQVRKLSAQKDEGSGSEAPSDNESDMDVDKDNKTESSGKGLCSNCNASAQLFSTAKGSLCYPCTQYFKRTGTLRSSGTMRTSARHNLTRSKRKPPRGMHLNYDDLVAIVTNAAGEEDAILRGMDCEIISFKRQVQLNKQKISEVKEKIAAGIDHLRPPETANRFNTRWLNDELLLAVQGIRKYGRDFKAVAEIVGNKTENNVRNFFVNYRRRFNLDNVLQEYDAEHGIMSEESEEKLETENVAPVGNNSHPSSPLPQTAPPLLHPPHSPSNGTNSNGPQRLCPPALQQAASSRNNSGRTLLQQPPPLICPTNLYNGASKAVMPGYDVSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBJ2</accession>
    <name>A0AAV6VBJ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_003795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000125">
        <property type="protein sequence ID" value="KAG8193310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBJ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="405" mass="45184" checksum="80D8BB15395AA902" modified="2024-11-27" version="1">MEPSKRLGKQELKLAMSMVPNIVLPPDIEHLNDSIMPNRNDKTPSESRFLQNTDEDIARVKQTPIVVLAQHMTTLGDSGHGKTQLHHDNSCLTKTADHKLTRTIPLPKVILPQEIETLDNSPRVERKTSRDSCGLPKPDQDSPRILQIPDVVLLPDKELPRDPTSSGLNRNGKTHSSFRLPKQPAPKQTHLCRHHSDSEAKDRKVDILPKRRIRGKRVRRSVSAIETNKQSNYRPKVRRSFSDRSGLIMAGKHLAPPAPSSSRSSRLYDSSRCSSIKTMSSNVSLSEIVAVEMGLKDIPGLTIKEARRRRVVLTVMLVFSILLVLSVALVAVTLLLSPAVDELSLREERVEQSNRNKPPHFPGRMGRLPFRRSPMGFGSGPVTSHPCHFTQAQIDKNLPSARGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBU3</accession>
    <name>A0AAV6VBU3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleolar protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_003019</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000109">
        <property type="protein sequence ID" value="KAG8194074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBU3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042859">
        <property type="entry name" value="NOL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048897">
        <property type="entry name" value="Nol11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012584">
        <property type="entry name" value="NOL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633:SF2">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20998">
        <property type="entry name" value="Nol11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08168">
        <property type="entry name" value="NOL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Nucleolar protein 11 N-terminal" evidence="7">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 11 C-terminal" evidence="8">
        <location>
            <begin position="405"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8194074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="61723" checksum="EE1372666F0CC82A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCE0</accession>
    <name>A0AAV6VCE0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_029208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000104">
        <property type="protein sequence ID" value="KAG8194335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCE0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043484868" evidence="2">
        <location>
            <begin position="23"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8194335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="243" mass="26604" checksum="92ADF325DB92E9DC" modified="2024-11-27" version="1">MASIGRWLYRLFSICLPCLKSAETDEKTATTLSNELTAPPSNGSSSKFPLPHEEKPDDEKSEAKSDESDHQGNEYPDSLNPFASEDEEDDYPEALNPFAREDEMPQSSSETPCPEALIYKDNEYDEALNPFVSEDVENNDSILKNPSITVDPQQTAATVNGSFSLVPLANERKKRKSTQKYRAPDPPITMRILPSESATGVNESSPGVNDSAAEVNDSAPGVNESAPEVNDQLQESMISSRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VD51</accession>
    <name>A0AAV6VD51_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">[heparan sulfate]-glucosamine N-sulfotransferase</fullName>
            <ecNumber evidence="5">2.8.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">JTE90_013655</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; heparin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sulfotransferase 1 family. NDST subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.8" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000112">
        <property type="protein sequence ID" value="KAG8193958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VD51"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015016">
        <property type="term" value="F:heparan sulfate N-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000176">
        <property type="entry name" value="bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021930">
        <property type="entry name" value="Heparan_SO4_deacetylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056793">
        <property type="entry name" value="HSNSD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF56">
        <property type="entry name" value="BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12062">
        <property type="entry name" value="HSNSD-CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25119">
        <property type="entry name" value="HSNSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan sulfate-N-deacetylase N-terminal" evidence="22">
        <location>
            <begin position="102"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan sulphate-N-deacetylase deacetylase" evidence="21">
        <location>
            <begin position="325"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="20">
        <location>
            <begin position="619"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="16">
        <location>
            <position position="628"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="726"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="848"/>
            <end position="852"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF12062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF25119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG8193958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="897" mass="103825" checksum="B160B711032A45FC" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDW5</accession>
    <name>A0AAV6VDW5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000103">
        <property type="protein sequence ID" value="KAG8194376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDW5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9592" checksum="98692767CCFBF0DA" modified="2024-11-27" version="1">MKGDLDFIDAYFSAIAAPPVSVTRLSRVASRSSNTDQMHEETAASLICVYRALVNPNLNPSCTEIRWLYPPLVICRSSDAAIRFGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF83</accession>
    <name>A0AAV6VF83_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Fanconi anemia group M protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_028420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000090">
        <property type="protein sequence ID" value="KAG8195269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:3'-5' DNA helicase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:four-way junction DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:four-way junction helicase activity"/>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="DEXDc_FANCM"/>
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        <property type="entry name" value="FANCM_ID"/>
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        <property type="entry name" value="Fanconi anemia, complementation group M"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031879">
        <property type="entry name" value="FANCM-MHF-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16783">
        <property type="entry name" value="FANCM-MHF_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="87"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="435"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1213"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1275"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1221"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8195269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2435" mass="272315" checksum="279C29FD10CA74F8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFL1</accession>
    <name>A0AAV6VFL1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cilia- and flagella-associated protein 61 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_001416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000089">
        <property type="protein sequence ID" value="KAG8195404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038884">
        <property type="entry name" value="CFAP61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032151">
        <property type="entry name" value="CFAP61_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178:SF8">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16092">
        <property type="entry name" value="CFAP61_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 61 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Cilia- and flagella-associated protein 61 N-terminal" evidence="2">
        <location>
            <begin position="520"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8195404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1530" mass="176396" checksum="87B94739185DBC9B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGN2</accession>
    <name>A0AAV6VGN2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000090">
        <property type="protein sequence ID" value="KAG8195253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGN2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7796" checksum="067E7785EB80E3CE" modified="2024-11-27" version="1">MFPRGRNKLDAIDLQYNMISTLPNACFFRHARSQICVSRGKMIAVLARSHFQPVLYHSFFHLDSRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VH97</accession>
    <name>A0AAV6VH97_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kelch-like protein diablo</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_007875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VH97"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18247">
        <property type="entry name" value="BTB_POZ_KLHL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030603">
        <property type="entry name" value="KLHL18_BTB/POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF497">
        <property type="entry name" value="KELCH-LIKE PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="8">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8196140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="565" mass="63075" checksum="923FB7CD9AAD9AB1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJP2</accession>
    <name>A0AAV6VJP2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_007855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJP2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF2">
        <property type="entry name" value="GH04238P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043798366" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8196119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33897" checksum="51F5AC6AEFC5A993" modified="2024-11-27" version="1">MRAIIGVNLAVSLFLFLLQDCNGVEIRRLSVPRWIQNGTEDSVVLDCDYAYNENDFRLVVKWFFQDNTEPVYQWIPALKKKHISETLKNRIDLNFSVTTKHEYSRYRAIKILRPTTELSGKYTCVVTSFAGQDSKEQVMTVFVPANVFDLSYIETSYKTVNVSCETLNVFPFPNLKLYLRPSSTSAPQAVTDVKTYSTQKPSGAFDVVVHRTFLIKELSKDSATVFECILELPGTNQHQSKRIAYIPGIQGSRLEKSHQLSSSHQLSGHFIGKCFISYVTSILFLHIAYLKILIWNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLD2</accession>
    <name>A0AAV6VLD2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_027577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLD2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="198"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8196865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="670" mass="76354" checksum="3BBCB43D4B8A8CC0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMJ3</accession>
    <name>A0AAV6VMJ3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N(6)-adenosine-methyltransferase non-catalytic subunit METTL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Methyltransferase-like protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_014499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000064">
        <property type="protein sequence ID" value="KAG8196766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMJ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8196766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="431" mass="48931" checksum="E373C4756A0998B4" modified="2024-11-27" version="1">MDTLKVLKEKSQKRRQLLAQQLGAGSSENLSLVLGSQDDRNACSAFKKPKKESFTAICAENVREETGVIKQSPSSHNPPDEESDDVSEVRTYTDSSTFLKGTQSANPHNDYCQHFVDTGQRPQNFIRDVGLADRFEEYPKLKELIRLKDDLIAKKATPPMYLKCDLENFDFRDLNCKFDVILVEAPLEEYQRTYGMTNMKFWTWEEIMKLDIEEVSAPRSFIFLWCGSSDGLDLGRQCLRKWGFRRCEDICWIKTNINNPGHTKNLEPRALFQRTKEHCLMGIKGTVRRSTDGDFIHANIDIDLIISEEPEYGSIAKPEEIFHIIEHFCLGRRRLHVFGRDVTVRPGWLSIGPALTNSNFNGETYNSYFNKGPEDFLTGCTERIEALRPKSPPPKSKGGGPGGNNRGGNSRGGGNRARMNSRGRGSHRGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VN89</accession>
    <name>A0AAV6VN89_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000043">
        <property type="protein sequence ID" value="KAG8198127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VN89"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="34" mass="3988" checksum="5C740FFF57C4FBC8" modified="2024-11-27" version="1" fragment="single">MALLEDSLIVSVSQVLFFAGGWVFFMKQLFRDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNT9</accession>
    <name>A0AAV6VNT9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_006897</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000043">
        <property type="protein sequence ID" value="KAG8198145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNT9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="14">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="THAP-type" evidence="14">
        <location>
            <begin position="703"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="791"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8198145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1221" mass="140068" checksum="A41D6C6CE9C711A4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP25</accession>
    <name>A0AAV6VP25_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Connector enhancer of kinase suppressor of ras 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_021492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNKSR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06748">
        <property type="entry name" value="PDZ_CNK1_2_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000060">
        <property type="entry name" value="Connector enhancer of kinase suppressor of Ras 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017874">
        <property type="entry name" value="CRIC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF42">
        <property type="entry name" value="CONNECTOR ENHANCER OF KSR PROTEIN CNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10534">
        <property type="entry name" value="CRIC_ras_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51290">
        <property type="entry name" value="CRIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CRIC" evidence="6">
        <location>
            <begin position="82"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="212"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="696"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="828"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1533"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1584"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="843"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1539"/>
            <end position="1557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8198235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1604" mass="179516" checksum="EC08A88A1FB84878" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPF7</accession>
    <name>A0AAV6VPF7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000040">
        <property type="protein sequence ID" value="KAG8198454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPF7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13174" checksum="663FF9846A368988" modified="2024-11-27" version="1">MLRLGKDKKKASSSSSNMAYPAQPTYGAYDQQPPQPGFGYPPNPQQPYYPQPPQPGYPQQPGYQPYQPGMPPTVAQPVGGGYYPGQPPTQTIIVQDSSNDDCAKDCCICALCVTLCCFCCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQF9</accession>
    <name>A0AAV6VQF9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000034">
        <property type="protein sequence ID" value="KAG8198859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQF9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="148" mass="16550" checksum="EB2D14D7FB79780D" modified="2024-11-27" version="1">MVSGRSRFNCDFLSMSSGTTQEVVVYFWWDSVCDTAGHLYSEDDSHLSLIHNEARPSHMSWWFVRFLRDGVRVAAGTEPREDGGGQGARSKFRGGQGRAFPPHGPPRITSGFVEFNPREVVVSCVFLSISKMWFGCTIGRMGINEIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VR39</accession>
    <name>A0AAV6VR39_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000028">
        <property type="protein sequence ID" value="KAG8199317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VR39"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="150" mass="17665" checksum="3FDB5A2D711CD654" modified="2024-11-27" version="1">MNYLRMYGGYLPRVLTRFGRTYGSLSHEVMVEKPMVAARLVTLEPKNKTETDSVTRNARPQCYNNGFFNTEEEKSAFLNFIGDSVVTSLDFNQHPYDTSEDVMEDPIPKPLPIVDFSKEKKRCKNGMWMRCDFKKKNFLRMKNFRNRPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSA8</accession>
    <name>A0AAV6VSA8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_009426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSA8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039210">
        <property type="entry name" value="OGFOD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14650:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14650">
        <property type="entry name" value="PROLYL HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="5">
        <location>
            <begin position="111"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8199589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="326" mass="36985" checksum="4176E7027AA42F4C" modified="2024-11-27" version="1">MAVHQRKPGNKKKEAKESSRDVNKDKIRKSKQDDSNEKQSIVSMIPWKKVFTRFLLSMGMIFAVYYTSKKENIHVFASQKEKVQLTSAEVSCSLSYHKDVSKFKECAPKHCGRFVTDLVVSPEEAAHLLRLCKKGMAFGGSSGGSSILDLHSGALSYETSFINLYEKLKALKKHSIFTAADYKVYSNVRNKIQQIISYNFGVQVSNVHLTHPTFFSEMTTRPPKTKHDEYWHVHVDKETYPSFHYTALLYLSDYGTDFTGGRFFFVSDGKNMTVEPRIGRVSVFTSGAENPHYVEIVSSGTRYALTVSFTCDPQYAIADPSIKKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSY7</accession>
    <name>A0AAV6VSY7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Orn/DAP/Arg decarboxylase 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_015102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000034">
        <property type="protein sequence ID" value="KAG8198888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSY7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="8">
        <location>
            <begin position="56"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8198888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="448" mass="50717" checksum="32819BD94FE1C93F" modified="2024-11-27" version="1">MSETNKSNNLEIDGEKFFELILTKSRQKCYSTYNKYIIDAASHLAEDQSFYTIDLADVLWKAQLWKQNFPNVVPYYAVKANSDPVLLRLFVLLGYGFDCSTEGEIRLAIKAGADGKNVIFAHTVKTTKALHYASFIGCDLMTFDSKEELLKIHHHFPKARLILRLKSASTQSVYNLSLKFGCEVSDAEDLLLTAKEMDLNVIGVSFHVGALCEDPKTFTSTIEDCRTVFEMAKKFGYVFTHVDIGAGFFGSKEREGYFYELSEKINKSLDDNFSFLNTDFIAEPGCYYVGSAVSLTTTILGKRNTSKLENENNDIEREYFVNDGFYGSFFEHKEMYDVKPKPVIDAIESSHRPHYLSRVWGQTCCSEDLVYDSCDLPDLEVGDLIVWENMGAYSRGVCSTFTEVPMPTTKHVFVKNNKLSLSWVPNVEALSDYIAVVADLVENEEIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT39</accession>
    <name>A0AAV6VT39_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_000908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT39"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12243">
        <property type="entry name" value="RRM1_MSSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12244">
        <property type="entry name" value="RRM2_MSSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000012">
        <property type="entry name" value="RNA-binding motif, single-stranded-interacting protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000482">
        <property type="entry name" value="SUPpressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF26">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="247"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="331"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8199819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="555" mass="60448" checksum="8115B7157F9B10CF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUJ8</accession>
    <name>A0AAV6VUJ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inhibitor of growth protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_024991</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000018">
        <property type="protein sequence ID" value="KAG8200212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUJ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15585">
        <property type="entry name" value="PHD_ING3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000103">
        <property type="entry name" value="Inhibitor of growth protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042020">
        <property type="entry name" value="ING3_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="4 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="394"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="221"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8200212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="452" mass="50851" checksum="4477E5717DA2584C" modified="2024-11-27" version="1">MGLLNRNISRVIRKRCAKGCNSLLFCHNNCKTTIKSTMLYLEDYLEMIEHLPQELRDRFTEMREMDLQVHNAMDNLDERVRQFFPNAKKLKPIERDSEYEKIRLDYYKALEDADEKVHIANQIYDLVERYLRRLDQELQKFKMELEADNAGITEILEKRSLELDNPPPPTNSMSSSYSRGEKRKLGQTSLSISSFTPDKQLGTEKVFSSLATEVMRETIGSNRVTLPGHSPSSSSTSSSSSTSSAQERSIVLTPQTKTTYVGTSALAAAASQAIAATQQSLKRGTSQSQSSLIQQGRRTASLKASYEAINSGQNLNKELTLGSREINSVVATPPNIASTVTVTNEPKKVNKKARTSQVAAQPIIEPPSLLDDSQDSSVLDENMMFLDAYDPNEPRYCICNQVSYGDMVACDHKDCPFEWFHYPCVGITQPPKGKWFCPQCAASMKRRNRKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUN4</accession>
    <name>A0AAV6VUN4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylosome subunit pICln</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_000897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pICln (TC 1.A.47) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUN4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034709">
        <property type="term" value="C:methylosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006821">
        <property type="term" value="P:chloride transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003521">
        <property type="entry name" value="ICln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01348">
        <property type="entry name" value="ICLNCHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8199805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="166" mass="18666" checksum="D5B8673E9C2B69DC" modified="2024-11-27" version="1">MVANLSVPCEGVRHTEFNTRAFWEDDELGNGTLYITESVLSWISSEGKGFSLKYPSIFIHAVSTDANNFPEPCLYLKIDGKIALRDAADVSNGDLVDDVEDMSLNSEEDESDDEDDIVESNELRFVPENSVMSQVNGQTEVLINQCYFPHFQLYLIMETDPLEEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXQ7</accession>
    <name>A0AAV6VXQ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000013">
        <property type="protein sequence ID" value="KAG8200828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXQ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13702" checksum="9CFBE25C5D40CFCB" modified="2024-11-27" version="1">MHKNTRKWKDYGFESFHFEDAKEALERLNGLEVAGRSMKIDRATKQPTWAEGHRSLEATTGRARHCPGSHWKDTAHGKAFEGLDLNISAAAVPALQMYQGFVTSKQVNKSNSHSNLLSLQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXW2</accession>
    <name>A0AAV6VXW2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXW2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="128" mass="14120" checksum="8DD3555EC1D22242" modified="2024-11-27" version="1">MVATPKRVCLLAVTTLIMRRPLNQPSKEDFAPLPSRVVIPVITEISHQVALLGFITSQFFNHSCPHGSPNAISTASCERWGLLRTIQDNNRAAMGNGAHAPKWGFRGVDEMSWGFLNHIVILLFQSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZ60</accession>
    <name>A0AAV6VZ60_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000006">
        <property type="protein sequence ID" value="KAG8201323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZ60"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="119" mass="12925" checksum="65F47C2E0C8E9800" modified="2024-11-27" version="1">MPQSVIEMTENECTVKDSGTLYAHTRKSLKRLLEHSQSSTATSWSAKKTETSKAPLSLKSTEQSSMSCSEKEIVEIVGDTESPLATQLEIGDEKRIEATDPIGINTGEKDGSVVGHRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TD39</accession>
    <name>A0AAV6TD39_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007701">
        <property type="protein sequence ID" value="KAG8155639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TD39"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="128" mass="13399" checksum="4449F886295A2CA5" modified="2024-11-27" version="1" fragment="single">PVFPTTGSNPPGPTPPKGAQKPPKLSTLHRPGSTAKTSPPVLPPLLDPQRRDLWAPPPAGGSSRGWLQTGPEERPRTAHVDPECAGGDPIFGDCGGTSAWGFVKERGQSTDCEQSTSIFLAPFAPIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDF4</accession>
    <name>A0AAV6TDF4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006876">
        <property type="protein sequence ID" value="KAG8155732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDF4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11004" checksum="5BA775A5D37F07D1" modified="2024-11-27" version="1">MKKLNHGLVGFVELAATRESGLTATVISLVEAIKLPSLAYAEFTQTDTSPGFNSSLRRYEITRPVALVNRVDVVRRYPKHSKSNHEPTSPATMGDFEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TES5</accession>
    <name>A0AAV6TES5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005622">
        <property type="protein sequence ID" value="KAG8170325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TES5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="127" mass="13931" checksum="74F3AA3FE75BD8B6" modified="2024-11-27" version="1" fragment="single">SCFTLGPLRIWVRTGTKITSLPSDCQGPNRGHRTPQETGAFTRTRPTPDEPIPGTNDSYKEKITLPRSSVDVSDSVALPHCPEGPISVSVLGILTPFPCGRQRDKHELCLRFSADVRASETDFLRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THB7</accession>
    <name>A0AAV6THB7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004664">
        <property type="protein sequence ID" value="KAG8170928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THB7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="109" mass="12439" checksum="B68B99B255F67DDA" modified="2024-11-27" version="1">MFRAPAPHQFSDPSVCPSKPKVISSGRAVCISKWVGAYSPRSLTRAAGPCEGPFRTGWRGLSRQGFWLMDEESRRRRVRICFVGVPGPFSRMWMDDVSLYFRRVSNRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THJ8</accession>
    <name>A0AAV6THJ8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_000491</name>
        <name evidence="5" type="ORF">JTE90_000493</name>
        <name evidence="7" type="ORF">JTE90_002510</name>
        <name evidence="6" type="ORF">JTE90_005368</name>
        <name evidence="2" type="ORF">JTE90_008344</name>
        <name evidence="3" type="ORF">JTE90_023926</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006535">
        <property type="protein sequence ID" value="KAG8155851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010004367">
        <property type="protein sequence ID" value="KAG8171148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010002839">
        <property type="protein sequence ID" value="KAG8172306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010002839">
        <property type="protein sequence ID" value="KAG8172308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010002810">
        <property type="protein sequence ID" value="KAG8172332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010002786">
        <property type="protein sequence ID" value="KAG8172374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THJ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8171148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8172306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8172308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8172332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8172374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="137" mass="14558" checksum="2DA53F81E3CA12A1" modified="2024-11-27" version="1">MPVTALGKRGLGRCDPPHLSDLTQSAKGSGAGPGPLRTRADNEVRRPHVQASLETRMASRAPPTCRRDLMSSSRNQATNVAPAHRARRRKSGPVARGSSTGGLYGTVDHQPPSTTGAPERESRASLTRVCLSNRKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIH9</accession>
    <name>A0AAV6TIH9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_026037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ANP32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003717">
        <property type="protein sequence ID" value="KAG8171668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIH9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000131">
        <property type="entry name" value="acidic leucine-rich nuclear phosphoprotein 32-related protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF0">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8171668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="189" mass="21570" checksum="A030FEA1F57D6D3C" modified="2024-11-27" version="1">MVILISDCPWKSKIWYSTNCRSTQIVGLTDEFSALESLSLINVGLTNLKGFPKLPNLKKLELSDNRISGGLNHLSGSPKLTTLNLSGNKIAGLEELEPLKDFANLKQLDLFNCEVTGQENYREKVFALLPGLVYLDGFDVNDKELEDSEEENGTHDKFPDDWIVMKTRMRRKMRTKMMREGTKRKEKWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIM2</accession>
    <name>A0AAV6TIM2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004076">
        <property type="protein sequence ID" value="KAG8171371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIM2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="31" mass="3393" checksum="2E254B4F3A52AC6E" modified="2024-11-27" version="1" fragment="single">MNEVSQFASSTEPDSDAFDVSADRSLTCLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKP4</accession>
    <name>A0AAV6TKP4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_014189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010002818">
        <property type="protein sequence ID" value="KAG8172327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKP4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="297"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="665"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="713"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8172327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="769" mass="88547" checksum="FEB810E01AB174A6" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLJ7</accession>
    <name>A0AAV6TLJ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type proton ATPase 16 kDa proteolipid subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Vacuolar proton pump 16 kDa proteolipid subunit c</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_004746</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002488">
        <property type="protein sequence ID" value="KAG8172660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLJ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8172660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="10358" checksum="942FE0C34BDF7977" modified="2024-11-27" version="1">MGLLANTQYAVYSIFTSIIVFVGLFYVLSGRGSRIDFGWLLTEISPFMWGAMGIGLAISLSVVGAALGIYTTGVSIVGGGVKAPRIRTKKSCEHHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMI9</accession>
    <name>A0AAV6TMI9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002147">
        <property type="protein sequence ID" value="KAG8173017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMI9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="12097" checksum="D11BD66881E80E4D" modified="2024-11-27" version="1">MKVFNSTRNKPIDHDIISVKGGEYWRLLTPGNYRIVAVKEGYQPISKNITVTNAPHAEATRLDFELVPNFEDEGDVLFDSMRSDPETLEILQLLDYLRSHKKADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TP62</accession>
    <name>A0AAV6TP62_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001825">
        <property type="protein sequence ID" value="KAG8173379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TP62"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9534" checksum="5CFED7F037B7822A" modified="2024-11-27" version="1">MCKRGGMEYTPQRMKVVGDVPNGPRAKSKSFEFINCFFSLCTLFSRRRTLLILPASLKAAYRLACALKVPLRRALSLPDPGGSCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPD0</accession>
    <name>A0AAV6TPD0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001687">
        <property type="protein sequence ID" value="KAG8173508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPD0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="7909" checksum="5F29DDFE784092FA" modified="2024-11-27" version="1">MQISLLTKCYDLFSEKNAEKFLNGVDSACVFHNSSSRFADGYRFGLGAEVGIRTAKIHARGPVGGGGGRRCVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQN2</accession>
    <name>A0AAV6TQN2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001426">
        <property type="protein sequence ID" value="KAG8173921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQN2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8566" checksum="8E442DD1B57B1BF4" modified="2024-11-27" version="1">MMDPNVYIKYNRLQNELTKRFCKDLTLDPDWREIRLKTVMDIGCGPGNTSTYWMDHFFPKIQKLIGVDIDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQT1</accession>
    <name>A0AAV6TQT1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_012423</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
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            <end position="113"/>
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        <location>
            <begin position="469"/>
            <end position="602"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8173919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="602" mass="70345" checksum="0D6468395BA954E8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TR67</accession>
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    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
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            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001240">
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    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
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            <begin position="1"/>
            <end position="20"/>
        </location>
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        <location>
            <begin position="113"/>
            <end position="204"/>
        </location>
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        <location>
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            <end position="402"/>
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            <end position="505"/>
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            <end position="568"/>
        </location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8174364.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="568" mass="63568" checksum="28C3FE7C1CB74EEB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TR89</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Oedothorax gibbosus</name>
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            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001288">
        <property type="protein sequence ID" value="KAG8174209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TR89"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="177" mass="20332" checksum="964F76DFC4F37281" modified="2024-11-27" version="1">MKGFIAFLEIFHSITVEISTEKHVSISKLPLFYGFMDDHVKMCRNEYKNRALQDVGRILSQQIADRLLKVVTINHVCEAVLLDPRFKELGLEVIKMDVITKEKVKAKLVDYHNKMIKCNPNSDQKQPSNSQKKSYWDAFDQNVSTKRPSSSAEANAIIEMDKYLSAPTINRKEDPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRD2</accession>
    <name>A0AAV6TRD2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001269">
        <property type="protein sequence ID" value="KAG8174254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRD2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="9172" checksum="5C9E9DAD8EFC2D70" modified="2024-11-27" version="1">MLNKLAHHHGLRLHAGQPTPKAFIYRHVVHISWVLYHSNSQFIVESNPTAFSRNIYNFVQNTCHRLTPISQPKILSPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTY3</accession>
    <name>A0AAV6TTY3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000990">
        <property type="protein sequence ID" value="KAG8175527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTY3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043798334" evidence="1">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="104" mass="12071" checksum="3D852579A1408F63" modified="2024-11-27" version="1">MYYVPQIGMLVVLLASWILSCQGLKDPDCSKMVFHPKCRGISAKRSSRLPFSDETEDSYNSEDSLEDSYWKNIVDSGLMERIMKEAIYASNFKKHPKSYYDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUW3</accession>
    <name>A0AAV6TUW3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000989">
        <property type="protein sequence ID" value="KAG8175529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUW3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="13097" checksum="D6EF45C972050942" modified="2024-11-27" version="1">MTFKKSSPKKNSKAVQKRNTTKPKLTKDSAPTNEAKQVRFSDPLKTNQKKSVSEYNIAEMLDIYQRYVEMEIVDDKTKRRKMSLHQIFQVLFDCNEAWMENYLEARIGEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TW66</accession>
    <name>A0AAV6TW66_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000939">
        <property type="protein sequence ID" value="KAG8175901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TW66"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="164" mass="17153" checksum="C543317E9B3FE073" modified="2024-11-27" version="1">MDADVSDVSPYSDEGDSDEEEPREKGLESPSVTPSPPPPPPSPPVPVEDVLPASECVQTPDTAVAVSSPPVPTPSPRSGPVVPKTNSARAVTASSSLPVKDARQASSRRSREPPSPADSGHCSSHDSRYNRGRRQPPYVSTTHENASRASSLHSSSWVPSVVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWG9</accession>
    <name>A0AAV6TWG9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_009662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000935">
        <property type="protein sequence ID" value="KAG8175983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWG9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039190">
        <property type="entry name" value="TTC14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184:SF9">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8175983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="50666" checksum="78AD87A374DA8914" modified="2024-11-27" version="1">MKLFIKEKHEFIHKDFKTSNYERPERVPDIPPMPVELFRNDPIPEKRNLFFKGLNRGDVLYLQVVNSFPDSYKLWVLAKHKAFAKVDDLGLIMYLPKLGPEMKLLKWELQKGDFIKAALCSCSLHERRLYVTLDESLLTVLGPDVEVVKLGHVTYHDLPYYIGNFKNRLSFVGYILRSDAFYNPGWSTQMSDILGFKNNHVYSFFEDWRGKTYPDQQYAVKLKEKQRLNQSVKYYNQAVLSYEERKIDETFSLLNKSLELNPKNVQALTTRGTVHANENSLRKAFVDTEEALTLDRSFEPAKKQMSKLLIALARTHLENNNYVKAQECLRMSSSLDGDNVELAKPLLDLIPTKVKNLNKTTNKNDSPVFLKPKAGSSKHHHSRKKSSSHLRKKDKKHRKKSHHYSRHSNRDSSSSSSSRSTSKDSHSSKRSKSKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWH4</accession>
    <name>A0AAV6TWH4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000962">
        <property type="protein sequence ID" value="KAG8175696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWH4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8787" checksum="1DDB6D96FBCDCB3C" modified="2024-11-27" version="1">MEHREIRIYEVCPSCREVECAGAFESPVSPRKQCPGALGDRVRENRPPRAGNDPERGNSSLRLQRSNAIRRKRSPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWM2</accession>
    <name>A0AAV6TWM2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_012958</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000915">
        <property type="protein sequence ID" value="KAG8176168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWM2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8176168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="393" mass="45074" checksum="54B8D656D5CF5E8A" modified="2024-11-27" version="1">MTIAFVPMKNFFELKGNSTKGIILEGIEAKLLETISKYMNINFKLVSPEDRQWGYQKPGGNWTGIIGMVARSEADMGLAYLSITESRTRVVDFSIPYSVLDRTFATEKPEPLSTLSNFTYPFSSGVWLSSLFVFMVTVFLFKFLMEKKRPWLWILIEVFGSMCGQNMRDDKRSWKWRLFLGFWLIYVTFLTLAYSVVLLSVITVPWSDNGIKNLEDLSEAVHNKGYRCLAAKGSADTEFLLTSQMNYVNTIGEAIIKNNWFYDPTKGLPKHLDTKTAIIGSRMRMHIAYGIPPYSLKHMSQSSFGVSHVGIALKKGFCCTEALNSVLLRILSSGIYQKYVEHEVYHEIQRSSKENDELAQDFSLSLQELWGEFILLFCGYFTSFLVFLYECRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZB8</accession>
    <name>A0AAV6TZB8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000778">
        <property type="protein sequence ID" value="KAG8177492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZB8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="683" mass="77822" checksum="9E0031FBECBA8935" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0F9</accession>
    <name>A0AAV6U0F9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000793">
        <property type="protein sequence ID" value="KAG8177273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0F9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="123" mass="13801" checksum="4BFFC4DB305F24DA" modified="2024-11-27" version="1">MSRAGAKALSTRFTTQSRAASAAADAKKKRVKVVARTQRVKNSISEFRLKRLKTRTTSNRSPPRTRCGIVGVEQKGWLERQGMSISYGLHKERVSWSAGLSQGRRTDPKVDDRKEVPISNQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U158</accession>
    <name>A0AAV6U158_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000792">
        <property type="protein sequence ID" value="KAG8177279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U158"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="679" mass="70947" checksum="C9960BD77994CFF4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1X4</accession>
    <name>A0AAV6U1X4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_000795</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000734">
        <property type="protein sequence ID" value="KAG8177932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1X4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="12">
        <location>
            <begin position="180"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8177932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="462" mass="51023" checksum="32230E0E6DA4B67A" modified="2024-11-27" version="1">MAANNILRCTKVASTLNTKYFCYNSQATYKFLIKKVPSLSCHQYITQNHFSTVLSSRQSNNRCYLYSLSNTLHSKSFLSTHINNDRYNVVINDPTAATSTELSSHIAQSLDSSSAAAASSAADASAATLTHATPITGELSEAVSHLAEPTLASLGLCNWTPVGLVQMFLEYLHIGWDMPWWAAIAASTVVARILLLPVLIKTQKNAVLMSNYMPQMQYLQAKFGEARKAGNTMEASKCANELMEFMKKHNLSPLKNAIFPLMQAPVFVSFFMGLRAMAKAPVESMSTGGIFWATDLTVPDPYYITPVIACSTLYIVLKIGAESGVRMENLKMAKYAMQALPIIAFPFLINFPAAVLYYWVTTNFCTLAIVSILKIKPLRKKLNLPNPVPLDPKFAMPKKGFISGIKESIEDQKVLAAIDDRRRTDEMRFLKAGIGPVPRTYSYDPTKPRPSNAAVSAKQRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2E9</accession>
    <name>A0AAV6U2E9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000701">
        <property type="protein sequence ID" value="KAG8178365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2E9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="198" mass="22688" checksum="6269DA3761BDE39D" modified="2024-11-27" version="1">MQGVRMSQIPRKQMTSAALPFFIGKRERQIRRKEKARIRMRLKRQKQKENLKMQTTTFEPEVVIKEEPIDTEEDHVFSRKDHELISPWDDSLQSGTMPTIGEVFTVIKTEPVDEDDEPQNNSNGNTKKASKGKAADVAQSESPSNEDSATKNSNAKDHFDVYGEYIAAKLRKLDWKSCAYVQKAFGDILFDAEMGKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2M6</accession>
    <name>A0AAV6U2M6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_025107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000710">
        <property type="protein sequence ID" value="KAG8178223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2M6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009801">
        <property type="entry name" value="TMEM126"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16296:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 126A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16296">
        <property type="entry name" value="UNCHARACTERIZED HYPOTHALAMUS PROTEIN HT007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07114">
        <property type="entry name" value="TMEM126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8178223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="201" mass="22672" checksum="4BD804D7C2240DE8" modified="2024-11-27" version="1">MVYQTVPNKPKLKHTDTSYFLDNVVATWKPRSETWHFRWGGDIGAFMGSLSALYIMYNLRRELKLRQYARLTCYLPVIGMAGFLTETMYDVFITPQILTGRKCPLCISTKAAALQIGLGVVYPLVLSPLIGFYLADRLLTYPVPSLSRAPGEMLKLWAKLVLKSPRPLIASAVLQGAVMAYITNEQQLFVINYVSSKNKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2Q5</accession>
    <name>A0AAV6U2Q5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DCC-interacting protein 13-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_011651</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Phagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000725">
        <property type="protein sequence ID" value="KAG8178021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2Q5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047181">
        <property type="entry name" value="DP13A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46415">
        <property type="entry name" value="ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46415:SF2">
        <property type="entry name" value="BETA, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="281"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="10">
        <location>
            <begin position="451"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="599"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8178021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="71010" checksum="01B76C1C35BAF7F9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3P8</accession>
    <name>A0AAV6U3P8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000675">
        <property type="protein sequence ID" value="KAG8178690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3P8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="98" mass="11121" checksum="56F9684DBCE47757" modified="2024-11-27" version="1">MLYETRTFKRLISPLPEMSFLGKVLLPLFPPRLKRKENRKKSSQAEESSSAQKTSSHSEKLDTPKKSSRVKEISTSQKPSSHSEKLSTKKKSSQAEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3P9</accession>
    <name>A0AAV6U3P9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000680">
        <property type="protein sequence ID" value="KAG8178613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3P9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="102" mass="11693" checksum="557CE49956E82D92" modified="2024-11-27" version="1">MAAILHTRFKLDWLPEDRKDEGKKKVASLLSSHNSFPPEQEENEENDDGDFFSFSKKEVTSTEDEAHCYLMCQDSCLSIHHGFSTLKSYLLNTIPDCSQVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5J8</accession>
    <name>A0AAV6U5J8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_016139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000619">
        <property type="protein sequence ID" value="KAG8179572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5J8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043349976" description="Receptor ligand binding region domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="7">
        <location>
            <begin position="87"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8179572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="158" mass="17424" checksum="ACF38A3A7ECB7904" modified="2024-11-27" version="1">MPIASILSSINVIQLLALASAINTNQNWPIRRMSNVSGDIVLGALFPIHERDSKYECGRLQGFIARNNAHSGEPQFLCSGGQVPTYRQGSFDRVVGIIGGQSSSVSIQLANLLRLFRVPQVSYQSSSPTLSNKEKYEYFFRTVASDVYQAKAIVEILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6Z7</accession>
    <name>A0AAV6U6Z7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calx-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_026340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000627">
        <property type="protein sequence ID" value="KAG8179446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6Z7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF76">
        <property type="entry name" value="CALX-BETA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calx-beta" evidence="5">
        <location>
            <begin position="99"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8179446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="318" mass="34978" checksum="DE68FBFD9A0E10CD" modified="2024-11-27" version="1">MKSESVKSLIACYLREKQSSSHYDEVDGLSLAQCSLAGESFGSRQNRCAEMLCVAPAAPQPVLGDYLGPLEPQEESIVRGIGRQLCEIAEEFELDHMKAIENQASALGSKMVQFKHRCMPVAPSCGHIEIPVVRMGNSGGTANVAWRTINKTAIAGAHYSSSRGDISFAEGDKEKTIEIEIIRNQGDSDVCFVVELFNPEGTEVGAVNPLTVYITDHTNLYDDEKQVVENIINCGPNTSITNISWCLRDKVTVNTFKAALQCACSNANSIPEELALGFELLRVSLQSARFDQLTNVICNFFNHLPELEDIAQYFDEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U736</accession>
    <name>A0AAV6U736_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SPRY domain-containing SOCS box protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_025083</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPSB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000605">
        <property type="protein sequence ID" value="KAG8179751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U736"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12876">
        <property type="entry name" value="SPRY_SOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035754">
        <property type="entry name" value="SPRY_SPSB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF12">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="8">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="9">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8179751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="253" mass="28990" checksum="A534F45815C5DD24" modified="2024-11-27" version="1">MTAMSQDDPPLQSYDPQEGPPLNTFYPDNWTWNKRDKSHEVRLHGENKTAHFHPNWSNGTAGVRGTRILNRGRYYWEINVSQRIFGTSMMFGIGTKRARLHTNVFVNMLGEDDQGWGLSHKGLLWHNGKFRQYAKPFRENEATTIGLLFDGIKAAKTEMTLGVTRRAFGNLQDQCRRVILKSLKSFGDVGELNLPTILKKYLADGPTDVMPRKDVAKYSPRHAYGLRSKSCGPHRKNSLKSFPYSEDNCKYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U795</accession>
    <name>A0AAV6U795_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000589">
        <property type="protein sequence ID" value="KAG8180044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U795"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11298" checksum="827E438A61BFEB2D" modified="2024-11-27" version="1">MNEDQIAQMKNLIWKYMKCFSNVPGKTELVMHDIELSEEQSILSKPYRTSPRQNAILKTEIQKMLDLKIIEIGFSDCTSPMILVEAVVRIRGLALTIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7X1</accession>
    <name>A0AAV6U7X1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TEP1-F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_022774</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds covalently through a thioester bond to the pathogen surface resulting in pathogen clearance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of a TEP1-N chain and an TEP1-C chain non-covalently linked. Forms a complex composed of TEP1-N and TEP1-C heterodimer, LRIM1 and APL1C; the interaction stabilizes TEP1-N and TEP1-C heterodimer, prevents its binding to tissues while circulating in the hemolymph and protects the thioester bond from hydrolysis. Mature TEP1 and to a lesser extent full-length TEP1 interact with SPCLIP1; the interaction is induced by microbial infection.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000564">
        <property type="protein sequence ID" value="KAG8180427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF171">
        <property type="entry name" value="PREGNANCY ZONE PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="12">
        <location>
            <begin position="463"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="13">
        <location>
            <begin position="842"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8180427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1509" mass="167102" checksum="AF3D46F3842A46AD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9V1</accession>
    <name>A0AAV6U9V1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000524">
        <property type="protein sequence ID" value="KAG8181272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9V1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10515" checksum="E303C9D8B1DBC5D3" modified="2024-11-27" version="1">MGAQIKPPPGTGPYCFRIHGQIYHMVSPLYAGSEQKAGYGQLHIFDSSEATIQRMDSNKGCSEILMQQLDSVLREVNPFAESYTKMRCRKVWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9X9</accession>
    <name>A0AAV6U9X9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_000778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000533">
        <property type="protein sequence ID" value="KAG8181125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9X9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007624">
        <property type="term" value="P:ultradian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038876">
        <property type="entry name" value="ENOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001:SF4">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="509" mass="59671" checksum="E8794AFCF76874B4" modified="2024-11-27" version="1">MFGRKQDTNKVAGDCAKRRPGLAKRRYKRRKRESVPSFSQVDESVTMMDHLWMDRQHINHSMEPIAPVWQFTDGENFDPYSANGFRENRLPSTQRWRNLRMFNNGTQDDPLLISEEIFRENVNDLLNGIDECAENPAQWSRDRTNSYFDKIQRFLDSWKRQLMKEDEKMDLEVLLVKRKFENKHDSVTNRLNILTGVLRESMCFMEFSEFQKRNMQSKVEDLNHVRSSVGERGHLVLSESSLAIELKTANEELIEARRQADEYCEELRQLRDNLKEANLKLNELTHAKNLRTQVDQQVMLDKCLQDKEQELKELKKQIDKGAEKQTNTETELVRTREQFQSFALKSLEINQTKQMESNKMLYEIQTSLCKKNPEYKPMCQSENESLSQEKLFKDITALIENDLQWVSRDNNCKKNTTEIALDSGSMSLRVSEYELHLVTLISSFLKVTPFPVKSSYIHSYVANIDNVVDLEFVENLLRKLPSLFKEVAVVPGSVDKNWTYLDLKPVITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UA39</accession>
    <name>A0AAV6UA39_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000566">
        <property type="protein sequence ID" value="KAG8180365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UA39"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043787080" evidence="1">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="7282" checksum="8ADBC4659FF3F9FA" modified="2024-11-27" version="1">MNMKVRIFFLVVILSQLLTIHGAPQNPAAAAGSAAEAAAAAAAAAATGAAEMVSAGAKMTAAAIGAGAQMASKAAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAM8</accession>
    <name>A0AAV6UAM8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000541">
        <property type="protein sequence ID" value="KAG8180923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAM8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23875" checksum="12B10150C91FAEA4" modified="2024-11-27" version="1">MNSWKAGEYISPYHPQSNGLEERAVEACNVLLKRCQKDNSDIALALLNVRNTQREAGLMSINQCLMSRTTRSLLPSTTTSFKPRVVEGATESLGLLREKKTAAANRHIISQRSPPSMNPGEDVRVQAGPRKWVAGKIEEMVNPRSAIIKVGDKTIQRNTIHIHPTSVELPPPFKSSINVQSNTSCPATQHQLKEIVHSFSTSTLQMIKSPEVRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UC96</accession>
    <name>A0AAV6UC96_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000494">
        <property type="protein sequence ID" value="KAG8181804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UC96"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="10772" checksum="0311974E178A57FD" modified="2024-11-27" version="1">MSGLSLKQYLNELDDVLQAGEGESVSECLSIQHDHAASSKVYSAPNVESTVKKRFDQPWDEVIILHIRCLQEIHRDNFVEAFKHHFALVQYPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCX3</accession>
    <name>A0AAV6UCX3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C-mannosyltransferase DPY19L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_003991</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000493">
        <property type="protein sequence ID" value="KAG8181844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCX3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20177">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047462">
        <property type="entry name" value="Dpy19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF1">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8181844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="80216" checksum="F316961DFFCF96D8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDW6</accession>
    <name>A0AAV6UDW6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_017661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000452">
        <property type="protein sequence ID" value="KAG8182682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDW6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000035">
        <property type="entry name" value="Calcium and integrin-binding family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF1">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8182682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="222" mass="26397" checksum="37416191D0B494C3" modified="2024-11-27" version="1">MYLTHSNKVIFSQRYSGIVFEWIRITLHVWTSYRRKEAMGNTKSQLTKLELQYYKELTYLTEREIQYAFKRFKNLHPRLLNKEKHARIPIDIIKRMPEFQNNPFRDRICEIFSSEGDELWSFEDFLDMVSVFSPATPPERKAEYAFCIYDFDGDGYLSKEDLTKLISRLIGSQKLDVNDLEDVIEKTMEEADIDKDGMLSPGEFKHVLMKCPDFSRSFTIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIG5</accession>
    <name>A0AAV6UIG5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_002845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000416">
        <property type="protein sequence ID" value="KAG8183463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIG5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043630524" description="LRRCT domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="6">
        <location>
            <begin position="423"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8183463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="669" mass="75185" checksum="62B9322903204561" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIS3</accession>
    <name>A0AAV6UIS3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000413">
        <property type="protein sequence ID" value="KAG8183568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIS3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="320" mass="35842" checksum="B4B3A9AEB5250757" modified="2024-11-27" version="1">MTSLDNDVVTLDNDVITLDNDVLPSTMTWFTLDNDVFTLDNDVFTLDNDVFTLDNDVFTLDNDVFTLDNDVFTLDNDVFTLDNDVFTLDNDVFTLDNDVFTLDNDVFTLDNDVFTLDNDAFTLDNDAFTLDNDVVTLDNDVVTLDNDVVTLDNDVVTLDNDVVTLDNDVVTLDNDVVTLDNDVVTLDNDVVTLDNDVVTLDNDVVTLDNDVVTLDNDVVTLDNEVITLDNDVVTLNNDVVTLHNDVVTLHNDVFTLKNDVLTLNFQRSGVKHLEPLVVEWQRSGVEEPFDGGCRVTRRFALERDASICREGLLCLSLFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJX3</accession>
    <name>A0AAV6UJX3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_013080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000364">
        <property type="protein sequence ID" value="KAG8184687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJX3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="447"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8184687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="646" mass="71489" checksum="910F68A02B9DC15A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UK01</accession>
    <name>A0AAV6UK01_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein polybromo-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_022674</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000367">
        <property type="protein sequence ID" value="KAG8184624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05524">
        <property type="entry name" value="Bromo_polybromo_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05517">
        <property type="entry name" value="Bromo_polybromo_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05526">
        <property type="entry name" value="Bromo_polybromo_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21984">
        <property type="entry name" value="HMG-box_PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Polybromo 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="protein polybromo-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein polybromo-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000006">
        <property type="entry name" value="protein polybromo-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000002">
        <property type="entry name" value="protein polybromo-1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="60"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="191"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="371"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="519"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="663"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="13">
        <location>
            <begin position="929"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="13">
        <location>
            <begin position="1125"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="12">
        <location>
            <begin position="1336"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="9">
        <location>
            <begin position="1336"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="893"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1387"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1505"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="894"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1409"/>
            <end position="1419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8184624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1677" mass="194134" checksum="558090A84EC0CEDB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULE8</accession>
    <name>A0AAV6ULE8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_002756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000342">
        <property type="protein sequence ID" value="KAG8185227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULE8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF14">
        <property type="entry name" value="SERINE HYDROLASE-LIKE PROTEIN DDB_G0286239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="80"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8185227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="350" mass="39330" checksum="BAD4DBC78550A568" modified="2024-11-27" version="1">MIISRSCARRFSQHWAHPKVFRAQNVFHSSPNGSTVSNLRSYSNSEGVLGNNPSNIKEIEIPVPYGKLAGKAWGSEKATPVLALHGWLDNCGTFDRLIPLLSDQFYFVAIDAPGHGKSSHLPPGGLYTDLSMMLDLRKAIDNLGWKKFHLLGHSMGGSLALQFSAFFPELVDKCISLDVMKPFSAPADQVHFLKMNAAHKFLQLEKKLLNSPPVYTGKSAPARLVKGMHNEISEDGAKILLKRGSRPSECGKGIIFSRDLRCHPIEYISLESHEVVETFMTHLKCKLMIIMANSTHRLYQPETPETIEKFSILYKNSVEHFVYERVEGNHFVHLNNPERIAPIINKFLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMT7</accession>
    <name>A0AAV6UMT7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_007677</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000369">
        <property type="protein sequence ID" value="KAG8184561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMT7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
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        <property type="entry name" value="GPCR_2_secretin-like"/>
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        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FI21270P1-RELATED"/>
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        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BAIPRECURSOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
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    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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    <feature type="chain" id="PRO_5043742322" evidence="12">
        <location>
            <begin position="22"/>
            <end position="1020"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="716"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="740"/>
            <end position="761"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="773"/>
            <end position="793"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="814"/>
            <end position="832"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="852"/>
            <end position="874"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="895"/>
            <end position="917"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="937"/>
            <end position="955"/>
        </location>
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    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="13">
        <location>
            <begin position="359"/>
            <end position="412"/>
        </location>
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    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="707"/>
            <end position="948"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
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        <location>
            <begin position="260"/>
            <end position="304"/>
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        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="100"/>
            <end position="143"/>
        </location>
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            <begin position="263"/>
            <end position="276"/>
        </location>
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        </source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8184561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1020" mass="114089" checksum="91929D1D1A45983D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNE3</accession>
    <name>A0AAV6UNE3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_005719</name>
    </gene>
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        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000346">
        <property type="protein sequence ID" value="KAG8185123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="89"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="178"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8185123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="279" mass="31382" checksum="4B18A91581AFFC86" modified="2024-11-27" version="1">MCALYVGNLHPDCNEATLYQKFSRFGKLQNVHICRDFLTRQSLGYGYVNFFLLSEAENAISSINYDAILGKPIRVMWAKNKDKKFNVSANLFVKNIHPDIDERILHDIFSSYGGILSLKIAKRDAGGNQEVAGYVQFEDEESADMAIKSLNGKLIHGQVISVTKYKLKKTSQAEMKFNNVYLKNFGSRLKDDDLIEMCRKFGSILSAKVMTEENGDSKGFGFVSFKDPDSAKEAVENLNGFILGDKKLFAGRAKKKAEREAETKAALLKKIRNFLSQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQN8</accession>
    <name>A0AAV6UQN8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_007429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000315">
        <property type="protein sequence ID" value="KAG8186043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQN8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002331">
        <property type="entry name" value="Lipase_panc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF185">
        <property type="entry name" value="LD47264P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00823">
        <property type="entry name" value="PANCLIPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="111"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8186043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="554" mass="61723" checksum="B2C1C98A354D16EE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQU3</accession>
    <name>A0AAV6UQU3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000312">
        <property type="protein sequence ID" value="KAG8186099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQU3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="131" mass="14845" checksum="62CF35664E2C8BC9" modified="2024-11-27" version="1">MWKLLSTTLEMVEITHARSSKNSRDLSTGIDSTQLINYCTTYVHSPPIDDQLPVNGRDDGLESTMAGLLGTSPRTEPISQLDRTSLPSHRRMLFSIRKKRGVHVFQPILKSEPSSPLRSGRPRYEKRRQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UR27</accession>
    <name>A0AAV6UR27_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_008734</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000309">
        <property type="protein sequence ID" value="KAG8186204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UR27"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="11">
        <location>
            <begin position="726"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="458"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8186204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="926" mass="104972" checksum="B050911CF114D6A9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTM7</accession>
    <name>A0AAV6UTM7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_027213</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000271">
        <property type="protein sequence ID" value="KAG8187489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTM7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20956">
        <property type="entry name" value="IgI_4_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20958">
        <property type="entry name" value="IgI_5_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000017">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000104">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000324">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000719">
        <property type="entry name" value="nephrin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="7"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="115"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="209"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="300"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="397"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="451"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="543"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="639"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="748"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8187489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="837" mass="92438" checksum="75A606C80E5627A2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUQ7</accession>
    <name>A0AAV6UUQ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KICSTOR complex protein SZT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000251">
        <property type="protein sequence ID" value="KAG8188035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033228">
        <property type="entry name" value="SZT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918:SF3">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1847"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1990"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2618"/>
            <end position="2637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2809"/>
            <end position="2833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3073"/>
            <end position="3128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3439"/>
            <end position="3474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1890"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1926"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1941"/>
            <end position="1951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2626"/>
            <end position="2637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2809"/>
            <end position="2826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3439"/>
            <end position="3451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3463"/>
            <end position="3474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3695" mass="421627" checksum="28851C768AC3559E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UV93</accession>
    <name>A0AAV6UV93_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000245">
        <property type="protein sequence ID" value="KAG8188262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UV93"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="178" mass="19528" checksum="875B398B327FEB0D" modified="2024-11-27" version="1">MPRATRAYKKRKGFNFSGRKSNEIVIEGSTAAIPAPLVEAPVSSSSKKLGDLNSSYSGIHDNLPKNIIVDVDLLSFALEKCICERSLLLFYGREDISCNPIGQQGFGAIKTRTSSGRSDPMPPRLSNPGAHRAGTELPPLRSPSHSSLRLFGWENGGVFAYVLLGMRWNGLFWYIIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVQ1</accession>
    <name>A0AAV6UVQ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_001231</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. Maf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000258">
        <property type="protein sequence ID" value="KAG8187858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVQ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14717">
        <property type="entry name" value="bZIP_Maf_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000011">
        <property type="entry name" value="Transcription factor MafG, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024874">
        <property type="entry name" value="Transcription_factor_Maf_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129:SF48">
        <property type="entry name" value="MAF-S, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="61"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8187858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="143" mass="16918" checksum="6157E39916595BA8" modified="2024-11-27" version="1">MDNDWRNYVAVKEEPDFGTEMDFSNFTSNSEISDDELVTLTVRDLNRLLKTSGFSRNEIQRLKQRRRTLKNRGYAASCRNKRLEQKDELQIERSSVVRDIAVLKEENQAIESELYEIKKSYESLRQFAISRNIQIPPEFDMMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWV5</accession>
    <name>A0AAV6UWV5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_010062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000225">
        <property type="protein sequence ID" value="KAG8188970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWV5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033182">
        <property type="entry name" value="MIC26/MIC27_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14564">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC26 / MIC27 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8188970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="253" mass="28129" checksum="560A0BBA688047F9" modified="2024-11-27" version="1">MFVSKVPSIGACVGSIATIYSLSNSVKAEESACHDCKRLGKRLPKARELPIYCKKEDDVVIEYDKKSELPLLNEISVVRMQISGVLTYLDVFKEKAVHVYETGIAHSQSSLDYMTSEENQIPRIITITSAGLLGILLARKGGYFKKAFYGSIGSGIAFSAFYPSTAKEYFSSAFDYTKHHTTNALEQYGGYDAKKISEDASQQIEVIKKTLMLEGVTNKMKEWFEANKEKASKTLKEATTSVNKKDEPTKTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYC6</accession>
    <name>A0AAV6UYC6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYC6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="371" mass="40293" checksum="CFC2673EDBB98371" modified="2024-11-27" version="1">MARAVINKRQPQLETLFPEHLALHRVLQETSTRSHSQVFPTLSTFSEVAEHKLSLSEDDKKHGLKLKWRLNPKMKEKVTNTENINNNRNNGNGNSAAAISTGDNGNVYAGPLPLNNEETDDDDEQEPNENIPSYNVPAPRPFNNGPVVTSGAGAWAGPLPNNNGALPNFDEILRNPFKMLSLNNGNGNSAGAINSGDRGVYAGPLPMNNGQIANNNERQPNYNQNIPNNNVPVRNNNVPIPYNNGQMVSYSSSSACALINGNWVCQNDRNNGNGNSAAAISTGNNGDVYAGPLTLNNEKTAHNNEPQPNEKIPSYNNVPVPIPFNNGQVVTGGAWAGPLPNNNGFIPNFDEILRNPFSMLNFPQRPQVPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYG2</accession>
    <name>A0AAV6UYG2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_013742</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000219">
        <property type="protein sequence ID" value="KAG8189209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYG2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF5">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="20">
        <location>
            <begin position="14"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8189209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="475" mass="52187" checksum="DED0C61D368C469B" modified="2024-11-27" version="1">MCVDVEKPSYRFSVLFFNCLLTFGSYYCFDMPSVLQDKMEKDYHCNNTEKGTKNETCCEDCLGMSPSQYNMLYAVYSWTNAVVVIAAGFLIDKFGNRLGAIFFSSLCVLGSCLFATGAMYRGTDYMLPLMLLGRLVFGAGNGSLTIVQNRITTFWFIGKELAMAFGFTLAFSRLGSVLNFFLTGHLSDLVGMRTTLWIGVGLCGIGFISSIIVGFLDTYGFKKLGMSDVISTQSKNLRVSDVKYFPMSYWLIIVTIMFFYNGVFPFVADASKFIRDKYHYDDNTAAYFAGAVYDVSLLTSPFLGGLIDIFGKRGILCIVCSILTIPVFGLLAFSQAHPLISTLWLGVTYSVAAAAMWPSISIVVNQASTGTAMGIATSLQMIGIGCSNLIVGEILGKTDDLPQSDILLRWKYVMIYLLANVLCCVATSIALNYNDMKKGGILNLSRKETKEKLENQGASNSDKDALVESMHGIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYU6</accession>
    <name>A0AAV6UYU6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000217">
        <property type="protein sequence ID" value="KAG8189394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYU6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8191" checksum="E9D1FD5034C10C69" modified="2024-11-27" version="1">MDFGGSLGRGRSWHSPNLTSDQKLAALTLLRQPRTVCLAGLLANVRFWGPQGQGETSRALPASPRAPHPDPQTDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0J0</accession>
    <name>A0AAV6V0J0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000210">
        <property type="protein sequence ID" value="KAG8189608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0J0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="164" mass="19134" checksum="85DD5B6B566699A8" modified="2024-11-27" version="1">MKASCDSAIGKTEISLTSSRRIINEKLSEKNLFNETGWALPIRKYVKFTEKKCDFCQICNAKKERRLLKGEKTGIKTTPEKALKEMREKRNKDGTKAFLTIEYMTTQQIRSMLSRMAKKGKLVNIDDILEDDDPQEENIEQEEDRNEVRVILQEIIALDLEERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V103</accession>
    <name>A0AAV6V103_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_022492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000207">
        <property type="protein sequence ID" value="KAG8189677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V103"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043563376" evidence="2">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8189677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="146" mass="16949" checksum="2264A10211981716" modified="2024-11-27" version="1">MRLNILYLLLITTMLLVLGDCRPRTFTRPDASEIARLAQQLQDPESRQMGILGFTALGAMMFPILVSLGMASFVSHLPTVFKELASEFGIPATPPRNFFFFRKLFNQRNAYDARLEDILNNFQRRYSEFPEANENYLKFAYGRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V122</accession>
    <name>A0AAV6V122_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_016691</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000183">
        <property type="protein sequence ID" value="KAG8190452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V122"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14391">
        <property type="entry name" value="UBA_II_E2_UBCD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000010">
        <property type="entry name" value="Putative ubiquitin-conjugating enzyme e2 k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000021">
        <property type="entry name" value="Putative ubiquitin-conjugating enzyme e2 k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042614">
        <property type="entry name" value="UBCD4_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="11">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="10">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8190452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="199" mass="22187" checksum="5F7361DC3CF80A9A" modified="2024-11-27" version="1">MANIAAQRIQREFKEVIKSEEAARCAISVEIINDTYTELKGEIAGPPDTPYEGGNFILEIKVPETYPFNPPKVRFATKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVAKQYKEDPEMFKLTARHWTQAYAGAPKTPSDFDDKIKRLLDMGVEENKAREALSSCSWNLEKATESLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1S6</accession>
    <name>A0AAV6V1S6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_024857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="JAFNEN010000175">
        <property type="protein sequence ID" value="KAG8190722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1S6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10240:FF:000006">
        <property type="entry name" value="Thiamin pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.320:FF:000001">
        <property type="entry name" value="Thiamine pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="8">
        <location>
            <begin position="178"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8190722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="255" mass="28556" checksum="F3883AACE3C5CE67" modified="2024-11-27" version="1">MNNSDALDAMEWFPHRILSGEDHYALLILNQPINEEIELFVKRNWTSSPLHIAVDGGANQLKKLSDNVLEKCYIPEIICGDFDSATSEVLDFFKGKGTKVVHTPDQDETDFTKALRVTKEYVIENALQVSSILAIVRNGDRVDHMIGNLNTLFLARDIVSVPVFILGYNSLTWLLSPGHHKIHISQDMLDSHVGLIPLGKECEDVSTTGLQWNLDHSKMKFGGLISTCNKFDGSEIVTVTTDTTLIWTMEVKLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V228</accession>
    <name>A0AAV6V228_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000200">
        <property type="protein sequence ID" value="KAG8189888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V228"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="199" mass="21714" checksum="51425B4736B5C24C" modified="2024-11-27" version="1">MATLHTRNTHHVTCDANNIMTHSSRTPVACRERSISPLFEMEQEKGGGGARMRERIFVSKHSKTFRAAITLCVAPCHSNERCSPAGVEFAPLKCRATGRHCFRKRTPLADGYCANDMAQVDGCISGNAGSGVFCSVVIEVQAPYRLGSDKNIRARYVAGKPSYKTPSGLALDIHHGRMDAAEMGGQRLALRLVEFEGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2J0</accession>
    <name>A0AAV6V2J0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000169">
        <property type="protein sequence ID" value="KAG8191007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2J0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043540720" evidence="1">
        <location>
            <begin position="23"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="163" mass="18349" checksum="121B86FBA72F736C" modified="2024-11-27" version="1">MLQHTVVYFVAFFLIRIPVNHGKGLESEYELMWWLVQSADWGYSTNMSAGAAAGRTFAAVAHSTWTRKGLPEGVVFADDADARVVSVVRSRVSAGYSRAAEGAAAQRMARMRSPAALRREWKAWRMRVSEPFQEDFRLLVRLTNAAAKDSGEHAQSDRSRWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3V5</accession>
    <name>A0AAV6V3V5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000176">
        <property type="protein sequence ID" value="KAG8190712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3V5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="224" mass="25481" checksum="5E9DA42BCE44CD5E" modified="2024-11-27" version="1">MCCSPFVGTIVAGVLGIFQTFVNLCWNVPLIVGLSLNKTEIQTFMPFDNSEIDHPFVIYGVTILLALVNIQLMIFSCLLFKANHDLRTDWIAGWCVLVLSKSIINVLLGIYFLYEYGNDPLQRISNFRLAVLFSGIFFFWPVINVILFGMVFKRYRDIVKDRTSIRQVTIRRESCPPAEDTPPPYTPGPYIYRPPTLDAAQITGWSQQPLLNFDQDEAQQTGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V401</accession>
    <name>A0AAV6V401_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_020678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000159">
        <property type="protein sequence ID" value="KAG8191425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V401"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053069">
        <property type="entry name" value="TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46593">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46593:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="2">
        <location>
            <begin position="119"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8191425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="331" mass="36509" checksum="5AFB447FDBF4757B" modified="2024-11-27" version="1">MAVEAPIHAFPTPANVADHPTLPDNDHPMKETSVATVTIRTRHKRRCLLTASRLSSPKFLFSFIPACAVLIVLTYVLYIGREYVKYGLLWLDDQEEWIVCVVFLVLYTAVSFPLTWGYVLLNLACGYHYGLILGTLVTALAASAGIVFAHLLMKHYFIGTITAKLLGPDVLRATVSALQSAHAFKLIAISRLTPIPFGLQNALFAISPVCLWRYVGASALGLFPTQLISVYLGTTVRSMEEVLVDENAATVGYGVLILQVVLSVALLSFILRKARQELRKTVPGDLEEIIVGNKTKPLLEATKSDFNFNYISRKLPYACTGSSRLCLLHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V577</accession>
    <name>A0AAV6V577_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KIF-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_012349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KIF-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000155">
        <property type="protein sequence ID" value="KAG8191632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V577"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021952">
        <property type="term" value="P:central nervous system projection neuron axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990535">
        <property type="term" value="P:neuron projection maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022083">
        <property type="entry name" value="KBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321:SF1">
        <property type="entry name" value="KIF-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321">
        <property type="entry name" value="KIF1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12309">
        <property type="entry name" value="KBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8191632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="559" mass="64535" checksum="DA59FDF5EE877C3F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8V5</accession>
    <name>A0AAV6V8V5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8V5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF613">
        <property type="entry name" value="NUCLEAR RECEPTOR-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="81"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="376" mass="44439" checksum="632D95324702A117" modified="2024-11-27" version="1">MFKVFTRVLSRVFSCLRNEDIEAIKERETRKMSEKIVKRVIKNAEWHANNMKKERNYWDDEDEEETENAVRNARKDIDKDYKHSQCIASGKFAEFHKYYKKKEATKLLCKIQYSQNEGRKLDMPLWNKVNGHPNVQPLIQVYWTTKTTSFLMPYYPKNIANEIDDMFCKKKKDGFEKVKKWLREVLSAMQYLESKGLCHLKLMSRYIFIAKDGRAVVGGLSRLNLANKPMNSWDHKLLSVYFPPEMSPLNSFDGKLFDRWAYGMLSCECLTYFALRDVVKSSKNWQKHVYPTMCYIMDEKNFTGFIRSAFPWGKKIRDNEAKLALNFVQGFLREDPKKRISPSDAMQHKFLGEDDEFGPGPDKMWTNHTFSFNLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9U3</accession>
    <name>A0AAV6V9U3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_017823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000131">
        <property type="protein sequence ID" value="KAG8193071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9U3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18505">
        <property type="entry name" value="BACK1_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18506">
        <property type="entry name" value="BACK2_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18308">
        <property type="entry name" value="BTB1_POZ_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18309">
        <property type="entry name" value="BTB2_POZ_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000090">
        <property type="entry name" value="Leucine-zipper transcriptional regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000139">
        <property type="entry name" value="Leucine-zipper transcriptional regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000024">
        <property type="entry name" value="Leucine-zipper-like transcriptional regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="371"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="594"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8193071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="774" mass="88435" checksum="91EDF4C0A681E19E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VC80</accession>
    <name>A0AAV6VC80_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphatidylinositol 3-kinase</fullName>
            <ecNumber evidence="2">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_011505</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000113">
        <property type="protein sequence ID" value="KAG8193956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VC80"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032060">
        <property type="term" value="P:bleb assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050920">
        <property type="term" value="P:regulation of chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05165">
        <property type="entry name" value="PI3Kc_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000001">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000008">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003113">
        <property type="entry name" value="PI3K_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000341">
        <property type="entry name" value="PI3K_Ras-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF118">
        <property type="entry name" value="PI-3 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02192">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00794">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00143">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00144">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51544">
        <property type="entry name" value="PI3K_ABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51546">
        <property type="entry name" value="PI3K_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K-ABD" evidence="9">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K-RBD" evidence="11">
        <location>
            <begin position="202"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="12">
        <location>
            <begin position="337"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="529"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="780"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8193956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1179" mass="134310" checksum="360BAA46BE4E9EE8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDE3</accession>
    <name>A0AAV6VDE3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000109">
        <property type="protein sequence ID" value="KAG8194063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDE3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="112" mass="13044" checksum="0A6844864DC637E9" modified="2024-11-27" version="1">METVLRGLSYEACLVYLDDIVIVGKEFNDHLINIRKVLTKLRYAGLKLSLSKCHFFRREVKYLGHIVSSAECKQIRIKLKLSKTGLVRRMFMNFEVFWGSRLTTVGLSKVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDW7</accession>
    <name>A0AAV6VDW7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_011417</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000113">
        <property type="protein sequence ID" value="KAG8193856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDW7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000213">
        <property type="entry name" value="Zinc finger protein 624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8193856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="117" mass="13343" checksum="16322049FAA33294" modified="2024-11-27" version="1">MNALAAFECVLSCRRFKSFCRNVSLNTFHLFLSVNRGEKPHSCDVCHKAFARKSALRTHLSVHTGEKPHRCGVCNKSFSRKWRIKAHMLVHTGEKPHSCECIGFENGFMFALNCEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VE60</accession>
    <name>A0AAV6VE60_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000095">
        <property type="protein sequence ID" value="KAG8194982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VE60"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="129" mass="14253" checksum="D192C03624B70E95" modified="2024-11-27" version="1">MRKHPLIEFWEKNTCSKFSAGELDGATSLIGPLPPPLPPPPPQFIADYAMCLGCPSFEHTVNHCVGVRLLIANTKRNLIPNYPFTTPFSPLNCIGAWVDPVFWDGGRGHFQSIRGGWKGWKGGARLIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEK9</accession>
    <name>A0AAV6VEK9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_003018</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000109">
        <property type="protein sequence ID" value="KAG8194073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEK9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21983">
        <property type="entry name" value="HMG-box_SMARCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="301"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="11">
        <location>
            <begin position="301"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="264"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="352"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="38"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8194073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="781" mass="89605" checksum="4DDF972B1223236B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VET5</accession>
    <name>A0AAV6VET5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_000986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000108">
        <property type="protein sequence ID" value="KAG8194148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VET5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043820828" evidence="2">
        <location>
            <begin position="24"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8194148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="136" mass="14585" checksum="5B89BD1485C5C893" modified="2024-11-27" version="1">MVFERMGGALWVILATVLAVCSATVVLPTALHYVAAPVSSAKVTKVRMGTQTSELRGPRSGPRSLQPQDRVAPRRTNRAPCTNRAPCTNRAPCTNCPRCTHCAPCSTLARSSPGPHFSSAVEQEGIRMLLMALKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGX0</accession>
    <name>A0AAV6VGX0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_028964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000075">
        <property type="protein sequence ID" value="KAG8195990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGX0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8195990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="474" mass="53879" checksum="9C3B86CA96153068" modified="2024-11-27" version="1">MIFSDYECCKKPRQPTWPSPSHLAAFSPQQEKRQPPTDYCLPADRTFAQALHKGKEELKHYSQCLSCFTALFPLNPPTTQLLYSAYRHRLTEHGLRCIPGRTEGRFKMTAQLQSTPRHLAFISLALGFLVIWTAVLAGVLVSRTLKDEASAKEMTKVFYTHEDVGKVLFALGHELVSTVDWMLSTADKTNVENIVVTWKITNSMMDKIKEETPERWVTSVISMLDTLQERLTVFRETVSDTKTNPLSTVKFYLELSDWVLQRCFLLDYAGQHLPVPSLPYTLFVRGMAQRFGELALGTIYVKSDMSIDKSEFFKLKSGSEELMESAFHFTPRARTKWMELQEQEPGVQKVNQAVVEDMLSGDTLRGKKELANNYLDGVKEQIAMLLLTKEVLNTSLSSWVERLSQRSHNTLAFHMSIAIVAVIAVVLCLIVTSCSCSYLSKRQPDVEKHTNSQMPYSVLEKSVLSSNMKPQCYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJH6</accession>
    <name>A0AAV6VJH6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000078">
        <property type="protein sequence ID" value="KAG8195776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJH6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="225" mass="23833" checksum="0163275DFE69B12D" modified="2024-11-27" version="1">MKVHFIMKQIFTSNPPKLRCDSDDATKRRKASDATKKTKTVDAAKDLKSTSAAKKRKASDTTKNTKTSQTSKKTKAADAAKKSKAANAAKKTKAADAAKESKATNAAKKTKTADASRESKTAVDVVAKESKAANAAKNTKAADAAKESKAVNAAKKTKTADEAKESKSTDVAKKRKANDSTKKTKVAQTTKKRKTAGDAKETKETAAVKKTTSIKKTPAKKSNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKN1</accession>
    <name>A0AAV6VKN1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000073">
        <property type="protein sequence ID" value="KAG8196231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKN1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="106" mass="12459" checksum="06B08DE73BB3B386" modified="2024-11-27" version="1">MQRRIFFQGHVVETYKATCGAKTTVVCKEFFFSFCNSNKKTNNECFFKRFNLTLKVAKCEKKRCNIELSEDEEEIRRPAFQSVFSRRGSFCHFSVICSQKNCGVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VL65</accession>
    <name>A0AAV6VL65_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G patch domain-containing protein 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Coiled-coil domain-containing protein 75</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_014907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPATCH11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000055">
        <property type="protein sequence ID" value="KAG8197422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VL65"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="68"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8197422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="267" mass="31846" checksum="30BEAA7655D4BA79" modified="2024-11-27" version="1">MSDEDDYMSSTFLEVKEDVRPGLLPKAAKRKLEIEKKRIESNKIFKVKSRKELEEESRNIGLDSAIGSDNIGFAMLQKMGYKPGMKLGPQKSTTSDRGLMEPIRVKVKNDKGGLGREEEIRKRIEKRETKRQKIKFYREKETEILTEEFRERMRNKCGDRQAMRDLIKCQKVCQQLDEENGVREPMRPWFWYQQEKEVDDKEDEEEEEDEETVDDLLPEEKINFITEYIHPKYFYCVWCCIKFENEEDLNSNCPGPEKFNHEDLFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM76</accession>
    <name>A0AAV6VM76_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleotide triphosphate diphosphatase NUDT15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">MutT homolog 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Nucleoside diphosphate-linked moiety X motif 15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Nucleoside diphosphate-linked to another moiety X hydrolase 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_001574</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP. Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives. Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear. Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs. May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA. Exhibits decapping activity towards dpCoA-capped RNAs in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Interacts with PCNA; interaction is disrupted in response to UV irradiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM76"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000034">
        <property type="entry name" value="Nucleotide triphosphate diphosphatase NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="17">
        <location>
            <begin position="8"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8197644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="157" mass="18148" checksum="D89FB5E5D22A6620" modified="2024-11-27" version="1">MSTPGTDEKRPGIGIAVFVTHNSKPNCVILGKRKNGLGAGLYQLPGGKLEFGESFEEGAHREVFEETGLHLKNIEYTHTVNSFYPEFDYHYVTVFMKAEIDDSESNWISEPQNLEPNKNEWWRWVQWNELPSTEGLFWCFRDFMKTGINPFKKLQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VN70</accession>
    <name>A0AAV6VN70_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_006888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000043">
        <property type="protein sequence ID" value="KAG8198135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VN70"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8198135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34190" checksum="E74A51BC3E0C84C2" modified="2024-11-27" version="1">MQLSSDSPVIRELLNPEVAGRQFLKRAIQSNARKMAAVCCLCWALGTCVFVVVERLHTDITQKTSVSLPYHSHFIALEVAGGATYVTGFAGYWGALYQERDLVVVFKFIVLVSSIIELPVGATILTFSGKAVKQDTMTFVNSSVKEEEDFIFSIQRQLECCGSKSPADWVGSAWWEKERANQSSRVVPHSCCKDDDRRQRKCQEGPPPYKQVHTSRLIFTKGCHAKVVERRRHLLQSSGSIFCFCGVGKLASFFAIHYFTNTIIAKQQNLDELRSRNPSSVTSQEMETIERNYENRLKSFKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNH9</accession>
    <name>A0AAV6VNH9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_001575</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNH9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00503">
        <property type="entry name" value="Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00904">
        <property type="entry name" value="FRATAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8197645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="189" mass="22100" checksum="4DCC138CA3512BF7" modified="2024-11-27" version="1">MSCATWRKGSEFARLRWKTIINRILFAHFRQKSSSAITLKKTIFTVQHQFLKNTNFQILSINTFTDKPNSITTSVEYEEISEETLQSIGDRFEELLEDSNLNDWDVNYSNDVLTVSLNKDGTYVLNKQSPNRQIWLSSPFSGPKRYDYVNGTWIYKHDGKSVHQLLSEEFSKIVQKDVDFMKCSYSKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNZ0</accession>
    <name>A0AAV6VNZ0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_007273</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the peptidase C19 family. UBP8 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000054">
        <property type="protein sequence ID" value="KAG8197537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNZ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF33">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="17">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="16">
        <location>
            <begin position="158"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8197537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="498" mass="57424" checksum="393D9A8640CDBDD8" modified="2024-11-27" version="1">MNTGSCSHVENYKIKDGFSPYSLLHSNFITCLKEGSRERKAKLAYCHDCHMRRGRVHACLSCIYFGCFNNDHINRHSQDSGHIISVDLKFGNIYCHKCNDYQYDKDFERLSKKFKRKFGKMMGIEVYDSWEPTLEEVKLIKDNGGLKKVYNNSFIGLRGLINLGHTCFMNCIVQVLVHTPLLREYFLSDTHLCEMEDPKYCLVCEMFVTFQEFYSGNPIPHVPSRLVYLMWTHAKHLNGFQQQDAHEFFIAILDILHKQCQGEVPDETKRCNCVIDQIFKGFYQSDIVCQECNHVSTTYDPFLDISLNLGGGMNESENGVEQAVSLLDCISRYTQPENLSIQCTSCGSASRTKQLTLKMLPFVTCFHLKRLEHSLGSKKKNTTHVIFPECFDMSPYMSTNRGMQQNGPIEESKLENSDNKFCLFAVVNHKGDRDGGHYISYIRQQHDKWYQCDDSLVTSASVQDVFASEGYLLFYHKQIFKHGISSNFSRPKDPEMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP51</accession>
    <name>A0AAV6VP51_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_007552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP51"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043574445" description="Cuticle protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8197306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="27972" checksum="D242F1D0A776BFA9" modified="2024-11-27" version="1">MFAKVTLLCLATLAAAQYAPKYDGPSYPHAQPYGAHYEEKPQPYSFGYDAKDEYGATINRKEESDDYGNKRGSYGYTDGYGIYRQVDYVADDKGFRAVIKTNEPGTDNQNSADAEIHSDAAPAKYEAAPAYGKPYAEPAYGKPAYAPAPAYKPAPVYAPAPAYKPAYAPEPEYKPAPVYAPAPVYAPSAPKAYAEPAYPAHQEYAPAPYQPAHQEYAPAPYHPAPAPYAPVPVYEQKPYEAPVYSSSKYDSEPVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQM4</accession>
    <name>A0AAV6VQM4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_021055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000032">
        <property type="protein sequence ID" value="KAG8199042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQM4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04013">
        <property type="entry name" value="C2_SynGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057606">
        <property type="entry name" value="SynGAP1-like_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25321">
        <property type="entry name" value="PH_RASGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="173"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="5">
        <location>
            <begin position="351"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8199042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="61939" checksum="3F366CF249A668B3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRG5</accession>
    <name>A0AAV6VRG5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TFIIS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_003679</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFS-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000029">
        <property type="protein sequence ID" value="KAG8199252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRG5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS central" evidence="11">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8199252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="117" mass="13474" checksum="40CC3A4C47BD02EC" modified="2024-11-27" version="1">MKYKNRVRSRVSNLRDVKNPGLRANVLKGIIEPSRIAVMTADEMASEEMKKLRMKFTKEAINDHQMAMTSGTKTDLLKCGKCKKSNCTYNQVQTRSADEPMTTFVYCNECGHRWKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRI3</accession>
    <name>A0AAV6VRI3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000037">
        <property type="protein sequence ID" value="KAG8198668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRI3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="191" mass="21784" checksum="64B5D20BA43AE365" modified="2024-11-27" version="1">MLELRDEYSIVNRELQPKKNSFSPNGQSYLNIINRRGDIYLPRECCGVSRSGSKLEKRGLGKGVKNPNKFGYDWRGLSIKAPNASHKRQRPLVEGQMKLSPGERPAKWKARNKIRVRETKDCRSLKIAGVHGHVLLCCLMGEDEKDKNLLVHVPIELLDHSIWLIMAHISYGYLVVLLVSDSCAVTVWFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSF5</accession>
    <name>A0AAV6VSF5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSF5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8237" checksum="02B1B53BBC001ACF" modified="2024-11-27" version="1">MSLQQTLLLQHCGLKYESHLTSWMYRICWSTSRKTLASPCHSCGSPGNGCWLHLDRRTSSPPQGNIGCYSVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTK0</accession>
    <name>A0AAV6VTK0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_006213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000022">
        <property type="protein sequence ID" value="KAG8199969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTK0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000002">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="77"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8199969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="216" mass="25371" checksum="41E38A718CF597E7" modified="2024-11-27" version="1">MLEEFNDIFDFNQTAKRSGCTKVKHKINTDDIPPIKQRPYRISPAERRVIEDEVHKMFKADVIQQSESPWSSPVVLVKKKNGEWRFCVDYRRLNRVTKKDVYPLPRIDDALDCLAGARIFSLMDLKSGYWQIEVDDKDREKTAFVTPDGLFEFKVMPFGLCNAPATFERMMDTVLRGLKWNIQALLCYNMNTTSKDCKFRFSRKLQIITPFPKICW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTX2</accession>
    <name>A0AAV6VTX2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000030">
        <property type="protein sequence ID" value="KAG8199216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTX2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="10945" checksum="8032D6C87460D8E6" modified="2024-11-27" version="1">MSEARFFNTRSSHPIAAKDCCYHPVSFLGFGSSSTHLSSPSGEEFQDDPETKSLTGDLGQEMIPTQVQEVAAPGLLQMRDSKSEGFGLRSQTFEKSKSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUH5</accession>
    <name>A0AAV6VUH5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_028562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000016">
        <property type="protein sequence ID" value="KAG8200384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUH5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050101">
        <property type="entry name" value="CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13939">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE AMIDOHYDROLASE PNCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13939:SF0">
        <property type="entry name" value="NMN AMIDOHYDROLASE-LIKE PROTEIN YFAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="2">
        <location>
            <begin position="39"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8200384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="296" mass="33020" checksum="86BCC6C0A1C3A284" modified="2024-11-27" version="1">MIFRNLKKFTIPGLFKNNIPGINFFIHLSTTSSSDITAGVLIIGDEILNGQTEDINSLFFIKNLTLSDIKIRKIAILPDNVDAISTEVSTLSKECTVVLTSGGIGPTHDDVTYEAVAKAFSENLALNPTLMELFRDYFGPSADQNEAVKKFSSIPQTAMLNFGFDKHGNKTRFPLISVKNTYMFPGVPMLLQRSFDVFKANFFLHNKPLYIRSIFITLDEFSITPVLNDAVRLFQGRVKFGSYPAFNEKTFKVKLILEGADEAMVIEASDYFNHKLPRGSILNLNYSKSSSDPEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVV0</accession>
    <name>A0AAV6VVV0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Replication factor C subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Activator 1 subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_025017</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. The RFC4 subunit probably functions as a scaffold on which the other complex components can assemble.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Subunit of the RFC complex, an heteropentameric complex consisting of a large subunit RFC1 and four small subunits RFC2, RFC3, RFC4 and RFC5; the RFC complex interacts with PCNA. Forms an heterotetrameric complex with RFC2, RFC3 and RFC5; this complex has ATPase activity but is not stimulated by PCNA. The heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 interacts with RAD17. Interacts with ATAD5. Interacts with CTF18. Interacts with CNTD1; this interaction facilitates crossover formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000018">
        <property type="protein sequence ID" value="KAG8200241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVV0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000032">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000010">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="68"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8200241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="362" mass="40698" checksum="04E6A1A11C4E225D" modified="2024-11-27" version="1">MEAFLKGFKPGTKPKPTVKTDANPVPTTSKKTKRPTPWVEKYRPKCMSEVVYQDEVVAVLKKSLANPDLPNLLFYGPPGTGKTSTILALSREIFGDMFKSRILELNASDERGIQVIRDKVKSFAQQTASGVRPDGRPCPPFKIVILDEADSMTNAAQSALRRTMEKASKSTRFCLICNYISRIIDPLTSRCSKFRFKPLSKDTLSQRLNYIASEENVKVEENVIDAVIDFSEGDLRKAITLLQSAHRLKGEESITENDIADISGVVPMKWIKEIITVCESDSYEKLEKFVCNLSYEGYTTGQVINQLHDEVVFNDTFNDKQKSSICEKIAVCDKRLLDGGDEYLQLMDLCCTIMQQICHPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVW4</accession>
    <name>A0AAV6VVW4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_028772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Myosin is a hexamer of 2 heavy chains and 4 light chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000008">
        <property type="protein sequence ID" value="KAG8201102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVW4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005859">
        <property type="term" value="C:muscle myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF33">
        <property type="entry name" value="MYOSIN LIGHT CHAIN ALKALI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="3" id="KW-0518">Myosin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8201102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="157" mass="17365" checksum="B0E9CEDC2F7E1D2E" modified="2024-11-27" version="1">MADLKPAEVEKAREHFEIYDFQGEGKIDGTDLGDLLRSLDCVPTNATVEKNGGTKKRGEKKFTLEEFLPIFSQLKKDKEVGTLEDFMEGLKVYDKAENGTLLVGELAHVLLSLGERLNDAECDDVLKSCGGTEDDDGFIKYEPFAKAVMAGPFPDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVZ2</accession>
    <name>A0AAV6VVZ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000022">
        <property type="protein sequence ID" value="KAG8199989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVZ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="386" mass="42926" checksum="63B3D77A0FD1DB91" modified="2024-11-27" version="1">MSDIYDIIPANVKCFTYIDDIFLLIEAPSLEEIQSTVDRTMQRIEKWCDEWFLPLSTPKCAAINLSAKKEQPQFNPTISGQPLPWMQEVKFLGITFSRSNTFKPHFNSLSKKSLKKISLLKILGQSKWGAQTVDLLRIGNATVRSSLEYGSQVTEFAAKTTKKVSQTAQNSIIRLALGLPKWTPNPIVLSISGECSMSNRNSKRNASYFIKQYSLTQQTGVANTITNLKKIASPAVLSKVPCGDNLTNTTEMLNIQPNKIIPTEFPFAVAQSLGVEIHTSSYNFQGRSPNTQCTVNWFNDFRASIPVSTVILATDASKANRLLAIAAVNCRSKMVYSGGLPPINSVFTGEGLAIWLGRRKLVTEAKDYILFTRQHVKSSSPQKYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWB1</accession>
    <name>A0AAV6VWB1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000021">
        <property type="protein sequence ID" value="KAG8200013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWB1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="136" mass="15456" checksum="BDCB99EE870CEB70" modified="2024-11-27" version="1">MDEDGNCSTCTARKGPNTRTRERLQRYNVRAPFERITIDVLGSLPQTTNGNKYILVVLDYFTKWPEAYVILNQEATTVAEAMLQDWICRFRVPLLLHSDQGTNFTSAVFTILMDLLGVTKTCTTHLHPQSDGMIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYF9</accession>
    <name>A0AAV6VYF9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYF9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7600" checksum="B4DF99154C9CC7C9" modified="2024-11-27" version="1">MDMLPILGFDLDDRSGIPQASTLQWPWCSSSGSSINQTLNVTQLFKLDMVSKLVLRYFAKYSPVNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEC9</accession>
    <name>A0AAV6TEC9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006429">
        <property type="protein sequence ID" value="KAG8155952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEC9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8155952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="82" mass="9329" checksum="CE1F6B614773BC55" modified="2024-11-27" version="1">MGRRPDCLEQPKHLSWGPHERLASDALTGRWFHPTAPFCLLKKWPTGHSHLSRPAFVMQGGLLTHLKKFENRFEIVSGPKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFK2</accession>
    <name>A0AAV6TFK2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005176">
        <property type="protein sequence ID" value="KAG8170584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFK2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="181" mass="20211" checksum="9566E2CD0FA13262" modified="2024-11-27" version="1">MRNCNRQSPAQKRFNGLPIPVGKGKHTMIPSMWQGVWPRTSRSLQTCYCSASCAKRRQSSKKKRRTRNDPSVYLVARASSVIRINQTNHYTNQERPCTTTHEIKKELLICQSSPCPGLVGFAALSQIEPQAPLLVVTLRQFLKFQLCNHTSPGTQKLWFPGSCPACHLRNTAGSLAGIVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFZ2</accession>
    <name>A0AAV6TFZ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005071">
        <property type="protein sequence ID" value="KAG8170657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFZ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="153" mass="17618" checksum="8381EEECA6FC577F" modified="2024-11-27" version="1">MYDFVAVAEFLFLQGVLVPFRVIFTSTRNPDKTILLEADADTLQMTYADVRKNLQMSPLLFTQQRPTTHHLTCHVKHLTFYLGGKFTQDYLKEAWHEPRIVCLDSATHNLLLGLMPNVTLLDGQLRQNNSLDLSLRAARLLNTKLGLEPYWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGR3</accession>
    <name>A0AAV6TGR3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005052">
        <property type="protein sequence ID" value="KAG8170675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGR3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="95" mass="10154" checksum="E7BDA74066F2A3E1" modified="2024-11-27" version="1">MCASQWVLNKPAANEVQAGGGRPHSGSPFLAGGAPPETRRVPLWKWRSLRAKPLGPKNVPKNPDRARPKGNLGEVVAVLLRANRCQNLVCPGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TH60</accession>
    <name>A0AAV6TH60_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004846">
        <property type="protein sequence ID" value="KAG8170810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TH60"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7981" checksum="BC0243D98B29713A" modified="2024-11-27" version="1" fragment="single">LGSPTPPTDENDIYIDYSVGFWYEPSFMHEATLPPIYIKKEAKRQKMDPVVSGNQMKEHFSVFVYIILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THI5</accession>
    <name>A0AAV6THI5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004294">
        <property type="protein sequence ID" value="KAG8171209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THI5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="6793" checksum="CB649E302B6995EE" modified="2024-11-27" version="1">MGLAPTLGNSPGQGDLLQSPSPARSLLNATFPHALASGGFGAGLLPVHSPLLRESLLVSFSSAYLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TI87</accession>
    <name>A0AAV6TI87_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003755">
        <property type="protein sequence ID" value="KAG8171615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TI87"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="443" mass="48134" checksum="86678444D6866D68" modified="2024-11-27" version="1">MVGGFPPGERNTHRAAAGWLGVFFFRREEHSPRGGGMVGGVFPPARGTLTARRRDGWGCFSPGERNTHRAAAGWLGVFFPRREEHSPRGGGMVGGVFPPARGTLTARRRDGWGCFSPGERNTHRAAAGWLGVFFPRREEHSPRGGGMVGGVFPPARGTLTARRRDGWGCFSPGERNTHRAAAGWLGVFFPRREEHSPRGGGMVGGVFPPARGTLTARRRDGWGCFSPGERNTHRAAAGWLGVFFPRREEHSPRGGGMVGVVFPPARGTLTARRRDGWGCFSPGERNTHRAAAGWLGVFFPRREEHSPRGGGMVGGVFPPARGTLTARRRDGWGSFSPGERNTHRAAAGWLGVFFPRREEHSPRGGGMVGGVFPPARGTLTARRRDGWGCFFPRREEHSPRGGGMVGGVFPPGERNTHRAAAGWLGVFFPRREEHSPRTVVGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIC7</accession>
    <name>A0AAV6TIC7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003906">
        <property type="protein sequence ID" value="KAG8171487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIC7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="85" mass="9152" checksum="24B5841EC37B9FCE" modified="2024-11-27" version="1">MVSNVCLVLDGSDEMHGNHRWVLLGGYSRTRNLRDAELLLLLTALRKSMQVATKSRDSLVSSTGPSQRDPVAPGWTPNPCGCSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIF4</accession>
    <name>A0AAV6TIF4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004187">
        <property type="protein sequence ID" value="KAG8171296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIF4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="127" mass="13750" checksum="88EF7319306ADF4D" modified="2024-11-27" version="1">MNSMRPGLSLGKLRGEPLLDGSIIFTPQEPRLTIIWGGGQNRGTGLHQKFFPWPRPVPGIWVYLPFGSPTGGLNSATSTKWKRGGAPVPPPCGEKGFPELGADLPPGPLLSFCRRGFFQKPIDRAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIP2</accession>
    <name>A0AAV6TIP2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003962">
        <property type="protein sequence ID" value="KAG8171453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIP2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="199" mass="22884" checksum="223D47A542FACEC0" modified="2024-11-27" version="1">MSQAQFLIMESVSAAPENKNVNEEETNSSSSDNFFEKIAPKICEKENKAWEVESTSSGSEYMDISFYQQQEAVKPANSKLMPSTPKHQNVLKNKPLPNGQQKRENQDVFSENTLVKRPCGNTPSRGTPQGLTFRKQPVQDSFWTRPFRTPDKLIAGTPEHNMDKVNYQKTPTITPQRRFFKTPVVNRDEKFKKPKLPWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TK32</accession>
    <name>A0AAV6TK32_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_024227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003093">
        <property type="protein sequence ID" value="KAG8172117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TK32"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8172117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="400" mass="44930" checksum="FFCD82A56C8142F4" modified="2024-11-27" version="1" fragment="single">MVHKGILESISSSEWATPVVPVVKRDGSIRLCGDYRCTVNKSVKPYTYPLPTVNEVLSTVAGGKVFSKLDLSQAYLQLPVDDATSRLLTLNTHKGLFRVKRLPFGVSIAVAIFQKKMEEVFAGVDGVLPYLDDIYITGTDMTSHNLKLEEVLQRLDQAGLRLKREKCCFALPEIVLLGFRVNARGIQPTVDKVKAIHEAPSPTNVVELQAFLGLLNFYGSFLKRRSDILEPLHKLLQKDVPWEWTAEHEEAYKASKGLLTTDDLLVHYDEKLPLILTSDASSYGLGSVLSHLLPNGKEAPVAYYSRTMTKTERNYSQTDKEALAILAGVKKFHSYLLGRRFRIVTDHRPLLGIFNSTKPIPQMISPRVLRWSLSLQAYDYELEYRKGKDIANADALSRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TK91</accession>
    <name>A0AAV6TK91_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003337">
        <property type="protein sequence ID" value="KAG8171956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TK91"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="10950" checksum="621216EEF3796C6B" modified="2024-11-27" version="1">MRLGAYDALIQFNEGFSGTLKVFDELNIKNVGHFTLQNYRSFDNERIKNSKRHSTPTSKKRRQVLRSIRKKKIRNSERKEGVTYESGLFSALPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TL42</accession>
    <name>A0AAV6TL42_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002467">
        <property type="protein sequence ID" value="KAG8172680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TL42"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="133" mass="15222" checksum="7FB2F471B4A2FF50" modified="2024-11-27" version="1">MDRMDMVDAHNPTPVLNPKRGQNLCCREQFAPCQEADASKGANYPAAVACPGPLFPPFLSKDFLLPFCPIRFRTGPRTPHWPHRLLTPTQQDSSWTKKVCKEPTMAVFRDSVAPYRTEEDSRSFRENKRDRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLJ8</accession>
    <name>A0AAV6TLJ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_012579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010002594">
        <property type="protein sequence ID" value="KAG8172551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLJ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="79"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8172551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="356" mass="40835" checksum="C93AD9786A75A8A5" modified="2024-11-27" version="1">MDKTGVERLLLVVPKKYRNDLKAFCHEGTSGHLGVTKTKDIFSRHFFWPQCYKEIEDYVRSCDRCQRVGKPFDKKKAPMKIVPVIQEVFSKINVDACGPLPVTPSGKRYLLTAMCLSSKYPDAVPVEDITSVTVVDALLQIFSRMGFPKVLQLDQGSSFTSALSTTFLEKFGIKVVHSSVYHPQKLLPMKALDLLLLNWVHGKNLRTPLTLLYEKWLDVEETEGEPVTEYVFSLINRMKRCQELAISKMEEFQQKNKIWVRQEGSPGTTLRKLSETNYVVQLPGEKATSKVYHVNMLKPYYKRPEEVNYLISDLEGENDEEQMEIPCVDSNPNILDLEEMFQDYGESSNMNEDQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TP18</accession>
    <name>A0AAV6TP18_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001571">
        <property type="protein sequence ID" value="KAG8173644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TP18"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="128" mass="15264" checksum="E473E8202152F085" modified="2024-11-27" version="1">MDLSSNNIHNILNLYEYTSHLKMDSNRNTLVKLLAERFEDLIQEIDFFEFDLHQIKELLSEDQIGTRSYISAKSVDMETYFSQFRPRPRQLLLKEKPFILWDTPSTAYNPMADTQVEVNSYQYFLKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQJ1</accession>
    <name>A0AAV6TQJ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_028677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001423">
        <property type="protein sequence ID" value="KAG8173924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQJ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043327875" description="Neurotransmitter-gated ion-channel ligand-binding domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="4">
        <location>
            <begin position="33"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8173924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="194" mass="22332" checksum="5324C8A9D4E4E867" modified="2024-11-27" version="1">MKTIEKMWIIIILNLTIKTCCVFGRTSDVFPPDYNKHKSPGYKGHPAILYLELSILDIDRIDEGRMEFCLQTYVYERWNDWRLNLSSYVGRNAVAFPQTLVHDLLVPVLVFDNAKSGVLFDLSVPNSYVRVDDDGSLALASRYNLVISCQMNFVYYPMDTQLCFIKMALLSNPDYKVTLHWGGQKATGEEDFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TR19</accession>
    <name>A0AAV6TR19_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_022583</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001314">
        <property type="protein sequence ID" value="KAG8174119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TR19"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047126">
        <property type="entry name" value="RNF141-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12109">
        <property type="entry name" value="RING FINGER PROTEIN 141-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8174119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="201" mass="24014" checksum="229F38778C8687EA" modified="2024-11-27" version="1">MDAHNNYLQKAIRICPSEEEYLSRASDILWVAEGSFPDIQVLEEAILIEPLLNRDEFPFRAFMSMLAYFPFEKEEFFDADRVETAARQYADRRFPVLAWIWEEYILVYIYNYLVELLPETRLSSESIYKLGNSLWNALMRHTWPNRYFQSPSTCPVCFEPTISLQVRLTTCRHVFCENCILKWLETRNTCPMCRAIIFWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRI1</accession>
    <name>A0AAV6TRI1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001255">
        <property type="protein sequence ID" value="KAG8174314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRI1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="130" mass="14224" checksum="BC6F40DCEC1B950B" modified="2024-11-27" version="1">MFFIFPQVSLCPTSEVSVSDCISPGQDAFDSSSGTCSPLSLSDDNEIPSPDHGSDLGEEVVPGGKTKFECLLMVLHIVLRHGLTSVALEDILKLLNCIIGREILPKSCYMFDKVFSTTVKPIFNFFLCIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSC1</accession>
    <name>A0AAV6TSC1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001136">
        <property type="protein sequence ID" value="KAG8174820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSC1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="237" mass="27562" checksum="07B35EBEB6E31BF6" modified="2024-11-27" version="1">MDTQMPPADNPLDEIRRNDLEYEALMNHGSLWVQCRLCPFPSNRRVKVCHLPEHLAERHGMDTSDSCAFCYGEFRASGNDDVENRLSWVRHRHQCYYRLTTFQGFHEDGRLTMDISDELHATTFWRNSAWCASPLSNDFIPPLDIGEMNRGAAASDIPRSGEESLGEQRNDADSTVLKSKLYYLCRMNERRRRGLYAKNYHVARVEEQLVRANEQLIKQNKIIAELEKKDDLELARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUX7</accession>
    <name>A0AAV6TUX7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_028235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010001004">
        <property type="protein sequence ID" value="KAG8175436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUX7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase listerin N-terminal" evidence="3">
        <location>
            <begin position="60"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8175436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1042" mass="116844" checksum="9C3BD854529CD0F0" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVA6</accession>
    <name>A0AAV6TVA6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_029122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000968">
        <property type="protein sequence ID" value="KAG8175664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVA6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8175664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="98" mass="11178" checksum="7EE7B466632868CD" modified="2024-11-27" version="1" fragment="single">CSICIKKQIKGFIVLDEDFKLLTGADNLTEYTFNTKQAKHWFCKTCGVQSFYKPRSNPDSISVMICCVDSDTIQDVEVTDFDGQNWEDSIKILQPENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TW56</accession>
    <name>A0AAV6TW56_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_011576</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="JAFNEN010000963">
        <property type="protein sequence ID" value="KAG8175689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TW56"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17946">
        <property type="entry name" value="DEADc_DDX24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043361241" description="ATP-dependent RNA helicase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="154"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="436"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="195"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8175689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="697" mass="79437" checksum="B9221BE9001E938D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWU0</accession>
    <name>A0AAV6TWU0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Retrovirus-related Pol polyprotein from transposon 297</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_021351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000903">
        <property type="protein sequence ID" value="KAG8176254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWU0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043876878" description="Retrovirus-related Pol polyprotein from transposon 297" evidence="2">
        <location>
            <begin position="17"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Tf2-1-like SH3-like" evidence="5">
        <location>
            <begin position="102"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="284"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="4">
        <location>
            <begin position="388"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8176254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="55035" checksum="51B4AE041A259FA6" modified="2024-11-27" version="1">MARWNWCMARWNWCMAAELMHGKNLRTPLTLLYEKWLDVEETEGEPVTEYVFSLINRMKRCQELAISKMEECQQKNKTWYDKRAVKREFRIGDLVLIFATFKSNKLSPHWTGPGTILRKLSETNYVVQLSGEKATSKVYHVNMLKPYYKRPEEVNYLISDLEGENDEEQMEIPCVDSNPNILDLEEMFQDYGESSNMNEDRIAQMKKLVWKYMKCFSNVPGKTELVIHDIELSEEQSILSKPYRTSPRQNAILKTEIQKMLDLKIIEIGFSDCTSPMILVEAPGKDPRPCIDYRNLNKITKTKFFPLPNIEERIEIVSSAQYITVLDLSKGYWQIPLTERAQRLAAFVTNFGTYKPLRMPFGIKNNAPYDFSKMGKLEKDLLRGLKNDEEAFDVLKNCLCHYPVLYSPDYQKPFIVETDASDQGMGVVLSQLADNETEEHPIIYLSKKFTSVEKRYSVSEKECAGHHLCSFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TX03</accession>
    <name>A0AAV6TX03_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000914">
        <property type="protein sequence ID" value="KAG8176173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TX03"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="414" mass="46755" checksum="D61C6C07A6209393" modified="2024-11-27" version="1">MIKAYGFGIGKKDFKFLKYFMDCIASELSLCETGQKEIIIENLWKNAKFAVFLNLEEKEMLKECLEMVNSEILDQCAVGLYSFLSALIFKSPSPPTLSNLENIESCIHDVLKICDIEGFEIVANAIQSFFNITLHLTNKASLQNTEFSTDVHLLLEDRYEIGKCLATLDRPSADSCLPSLFQALQLIVDSTSSPAQELPHSSDVVSLPCLGSVFRECTGSMRYVVQYSVQKVFNWSIFIPFDKESLISRPGNFEYPTMEILFPNYDIPGVVRQGANSCITKTYSLLELCCQDLALNVKYALQDKSMNFPMRYESDCIESCYQAASRECSATEYGYTISIIKSVKLADVNMKKFGILFWPSKPPYGLPVHIFNNIQVCVKAMKRESLEKCCHGILNVFRAYATDQMPPPIFITPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TY57</accession>
    <name>A0AAV6TY57_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Amiloride-sensitive sodium channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_023680</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000857">
        <property type="protein sequence ID" value="KAG8176676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TY57"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8176676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36133" checksum="EAC3EF8380FBB523" modified="2024-11-27" version="1">MHSSSATGPFCSLTRDYRVSAVAESFRIIRVKSFLLSCSNVVSEPAVDRRGIPNTCFTFESLWGQPDAQPRSIPVTAYMQVHLMLHPEEYVFYRVPVKAFVLAHDPRALDNPIREGIVLVPGKSYSIYVSQTVTKRLPAPYRTNCTDYLKLWRENGGRGPLTGKSCSEKCKMELMLQSVGCVPQSVSYPNNNTICEDDKIVPTPEIMERCSRECADACSETTYHLSVEVDEDLTFKCSADDTHCKQQELYLQFLFNRFEVTTFVHEPKFERVSVFSYIGGYVGMWLGVSLIALFDLAETLVNLLVIYPLSQSSRGKTRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYE8</accession>
    <name>A0AAV6TYE8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000852">
        <property type="protein sequence ID" value="KAG8176704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYE8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10343" checksum="9E73D25B3CC39E47" modified="2024-11-27" version="1">MTAHAIVDLLCMTNNETSICPKAKDKDVPSNGRPRSNFSIPQPFLENVMLVSVYLTYFIKPSIWPLFGCFTFFLAKHLHVNLFPVLISSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZ44</accession>
    <name>A0AAV6TZ44_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_013194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000826">
        <property type="protein sequence ID" value="KAG8177044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZ44"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8177044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="165" mass="17890" checksum="D77AED301CDE177F" modified="2024-11-27" version="1">MGMGVACDGTTLWIAGGISRDGEHLNLCDSVWCFNKDNTRWIRKSTLPDPVAFPALLQNNGRLVLVGGATQSTGEDKNQLESVDTVLTLQGQMWTKKEPMSVQCHSAVAATFGNKIFIFGGLQTQSVSQLSEAIFYDGDSDEWAHLCDLPHDAAGFIVALAEQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0E1</accession>
    <name>A0AAV6U0E1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_024606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000738">
        <property type="protein sequence ID" value="KAG8177897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0E1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121:SF9">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8177897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="548" mass="60396" checksum="65342AB9B266C092" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1W4</accession>
    <name>A0AAV6U1W4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_006309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000713">
        <property type="protein sequence ID" value="KAG8178170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1W4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF80">
        <property type="entry name" value="TRANSIENT-RECEPTOR-POTENTIAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8178170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="288" mass="33005" checksum="C0BA707D5938289F" modified="2024-11-27" version="1">MLHCFVRFLMLPFLSLALVVFPWFRPLKKYHSPRCYHLLRLVFYLIFLLMVFLPNHLDTGKFNKVPPHTGVEDCILCGLKDRQHKRKVLERKFWRGDDAALLHEALFSVGIVLAFGNLAYFYQQSSRLGSFQVSMSRMVLQSAYFMGFCLIVITTSAIAPTRMYEFYDGMKRNDKGGNTRTQWSTFSTFGNSFHTLFWGMFGVSPAESTNVVIKILSPEEGVTEGTGTALFAFYEIIMIISLVESPVLVIDTNEDVTAFSYRDAQMRRPPDLDILHPADLVNPRANRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U320</accession>
    <name>A0AAV6U320_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_029447</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hunchback C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000714">
        <property type="protein sequence ID" value="KAG8178141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U320"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000005">
        <property type="entry name" value="Zinc finger protein 14 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000614">
        <property type="entry name" value="Zinc finger protein 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8178141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="330" mass="38857" checksum="86AD517CD24DCD78" modified="2024-11-27" version="1">MPKSNDPEDEQFECFVCSRTFKQKSYLFNHIQHHHRLRDSFVCEPCNRIFRTEDALLRHFYEHTGARPFKCDVCDEEFARKFILKSHLLTHTEEKPFKCDVCGKQFRRKFTLTNHMRVHVPDRETFQCGLCQKIFHVKSALANHLLKHSTLEPYKCSECNKTFSSKSNLNKHVIIHTNQRKFKCEECGRCFRVKTTLDDHVKTHTLEKPFKCEVCEFTSARKWSLSKHMKTHEDNRVHIKCTGCLKVFRSDYGFEHHACKYECKPVKRRKAKVSKSLIEDESVSDNLNVFVPNHVKKDSGVNSCVVVVDGDRYMHTESQSSTAQFYDDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U406</accession>
    <name>A0AAV6U406_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenomatous polyposis coli protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_015918</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenomatous polyposis coli (APC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000686">
        <property type="protein sequence ID" value="KAG8178548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045295">
        <property type="term" value="F:gamma-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000305">
        <property type="entry name" value="Adenomatous polyposis coli"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026818">
        <property type="entry name" value="Apc_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041257">
        <property type="entry name" value="APC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12607">
        <property type="entry name" value="ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12607:SF12">
        <property type="entry name" value="APC-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18797">
        <property type="entry name" value="APC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="526"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="639"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="718"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="758"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1029"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1266"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1371"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1656"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1894"/>
            <end position="2103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="769"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1272"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1309"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1389"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1656"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1679"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1928"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1972"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1993"/>
            <end position="2006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2021"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2062"/>
            <end position="2075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8178548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2103" mass="232400" checksum="3B926537DBB1204C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5R0</accession>
    <name>A0AAV6U5R0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_015333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000646">
        <property type="protein sequence ID" value="KAG8179143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5R0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="53"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8179143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="204" mass="23005" checksum="8E08A87E598E32EC" modified="2024-11-27" version="1">MNEYPNKQTYKEMLNSQNVSDNFVIMIILSNTFQEKLCFLKSNSQNNRTVEDISYKIFEGVALNAIFTLSDTACNESIQKHRGSFGQQRLWGGIVWGTVAPLAGFINDYTEGYLASYILMGVMMVLFLINMSTMALVKPHFSKNILKDVGTVLKSKDFLIFEAMVFVNGLGTVMIWFYLIWFLNSIGVASYYVGSQLLSSLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U693</accession>
    <name>A0AAV6U693_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000646">
        <property type="protein sequence ID" value="KAG8179150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U693"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="10605" checksum="7A522D906AFD471A" modified="2024-11-27" version="1">MRYLRQCATLLQPANLDRRVPASSNPTSHSLDVPREDDCVFYGGGVGNSIEEYGVLMVLVCDLDVRGGPSLKMVANNDSDIAAYWLTTPERTLTCAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6Y6</accession>
    <name>A0AAV6U6Y6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000627">
        <property type="protein sequence ID" value="KAG8179431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6Y6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="107" mass="11975" checksum="77CEEDE89A5D63A9" modified="2024-11-27" version="1">MSTRHNATAMSLQNLQYHYTYRVMRDNNGTWIGIRPGLVYANESIKLAFLVLVMVLLIFICCWDCSACASIKKVFQRRRRNEGLLVPIADGINRGTGTPHSAAGDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7Q9</accession>
    <name>A0AAV6U7Q9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000610">
        <property type="protein sequence ID" value="KAG8179645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7Q9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="143" mass="16996" checksum="8108E12987FBB1B4" modified="2024-11-27" version="1">MCTRKTLVVQLSCEEENFTTKLLYFSQYMKMARMISWMQRFVYNSLHCSKKMRGELTLEEVQEAEGKLFRCIQKECFQNEGAKVLEKMQTFKDDKGTIRIRTKLLHGDETNEFKFPVVLPGKHTIVRMSIMNTVQYNMQVQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7W0</accession>
    <name>A0AAV6U7W0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000581">
        <property type="protein sequence ID" value="KAG8180154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7W0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10041" checksum="42DEC1062EB03596" modified="2024-11-27" version="1">MPQGSHMKGGKSNPKKPKITKVSKKGSSVTKKTPKKVTDKKKLQKTLEKAIKANIEIEMRAKAGGSNAAEAAKEVKKQQNTRSKNARKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8V0</accession>
    <name>A0AAV6U8V0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_025450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000565">
        <property type="protein sequence ID" value="KAG8180400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8V0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8180400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="291" mass="31334" checksum="F67E02D66CBFB67D" modified="2024-11-27" version="1">MSLSSMFRLSTALNKQVFQRAVKASRSFSAAPTYEFIKVEKTGSKNNVGLITLNRKKALNALCAGLMKDVSNALDVLESDKDVGAIVLTGSERAFAAGADIKEMQNNTFAECITGSFLGGWDRIAKTKKPMIAAVNGYALGGGCEIAMMCDIIYAGEGAKFGQPEILIGTIPGAGGTQRLTKAIGKSRTMEIVLTGDQFTAQEAEKWGLVSRVFPADKVVEEAVKLGEKICANSKLIVALCKESVNTSFETTLDQGLKAEKRFFYSTFATKDRAEGMKAFGEKRKPDFTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9V9</accession>
    <name>A0AAV6U9V9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000559">
        <property type="protein sequence ID" value="KAG8180618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9V9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8510" checksum="DF4AC99933981354" modified="2024-11-27" version="1">MAIQKRDEKKATKIKHKRKETCDVQEQSLDSHSEEQTAEMETSLSVVPVEIRNEYVAKRSRREHKPKKVFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBZ6</accession>
    <name>A0AAV6UBZ6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000531">
        <property type="protein sequence ID" value="KAG8181151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBZ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="8238" checksum="3653ABC2C78D0FF6" modified="2024-11-27" version="1">METIVTDKLLQCVNIKEHNKEADIHLPLTGSRIHASRIAGNLQVTLKLPTEAFEIEHRQRSFSRLDCRWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UC45</accession>
    <name>A0AAV6UC45_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dynein axonemal heavy chain 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Axonemal beta dynein heavy chain 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Ciliary dynein heavy chain 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">JTE90_016598</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="16">The dynein complex consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000536">
        <property type="protein sequence ID" value="KAG8181085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000223">
        <property type="entry name" value="Dynein heavy chain 3, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001328">
        <property type="entry name" value="Dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000005">
        <property type="entry name" value="Dynein, axonemal, heavy chain 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000006">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF66">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="2185"/>
            <end position="2220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="2762"/>
            <end position="2824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG8181085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="3968" mass="453154" checksum="19BEB4084D6A3486" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UC98</accession>
    <name>A0AAV6UC98_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000513">
        <property type="protein sequence ID" value="KAG8181478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UC98"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="127" mass="13690" checksum="2E3A6D141FC0DBD2" modified="2024-11-27" version="1">MFYESPMTLFRRKSISAASVERNYPPTLVEGLGRIGLRVWAGVESFPPIPLDGSTLIIPHPPTSPPERGRVGRSRDVTPPRKTIPRALASTEGPMAVGSSASPIHHHLFSSSASSPLSKTSMDTRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFR0</accession>
    <name>A0AAV6UFR0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000458">
        <property type="protein sequence ID" value="KAG8182589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFR0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="8032" checksum="EA5AEE07C1379C32" modified="2024-11-27" version="1">MDLAGPLFTREGAKVWIVIFTCAIYRAVHLDRNGSSLHYMPDEKVVKDHQLLGDDCRGFILVMLQQVTGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UG52</accession>
    <name>A0AAV6UG52_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000436">
        <property type="protein sequence ID" value="KAG8183014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UG52"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="101" mass="11145" checksum="4B3427B369528E24" modified="2024-11-27" version="1">MRTVSFFLDTKNIMPQLKDSMASTKPSTNVLGVLSATFSPSDIFIWYKIQPLSTPFPCLKTSIHCPACSPSVPSFCLLTKAYHLQKRTTADVFSTKGVARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGX9</accession>
    <name>A0AAV6UGX9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_002804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serine protease inhibitor-like (TIL domain-containing) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000422">
        <property type="protein sequence ID" value="KAG8183314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="47"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000055">
        <property type="entry name" value="alpha-tectorin isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="48"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="50"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043843266" description="EGF-like domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="3406"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1003"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1245"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1429"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1822"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1891"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1960"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="2035"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="2096"/>
            <end position="2138"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="2268"/>
            <end position="2310"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="2337"/>
            <end position="2379"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="2410"/>
            <end position="2448"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="2617"/>
            <end position="2655"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="2686"/>
            <end position="2724"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="2755"/>
            <end position="2793"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="2824"/>
            <end position="2862"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="3190"/>
            <end position="3234"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="3251"/>
            <end position="3290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2209"/>
            <end position="2230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3069"/>
            <end position="3090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3355"/>
            <end position="3406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2221"/>
            <end position="2230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3362"/>
            <end position="3371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="3382"/>
            <end position="3391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8183314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="3406" mass="378644" checksum="393E0F6B78696F3C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHN3</accession>
    <name>A0AAV6UHN3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000433">
        <property type="protein sequence ID" value="KAG8183080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHN3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="85" mass="9645" checksum="D25F649C0F5C1350" modified="2024-11-27" version="1">MAACRPHVWPGFARESGLTLTLCLETDGRTDLLEHASSMNMGEMRGRLGITVVAQFKLKASQLRSYWYSQHQNVSLVLLTIYQYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHT8</accession>
    <name>A0AAV6UHT8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000404">
        <property type="protein sequence ID" value="KAG8183799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHT8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="175" mass="19794" checksum="067BF60A4BF44307" modified="2024-11-27" version="1">MNIMYRMTGGDHNKGEDDSANKKISKDPAKDRRNSKDSAKGKNNNEDDSAAIQDKGSKENGKKVARNNNDTKEVRKLFDSRVKAGDPHRINGGLSMEDTRKWFQDAAMINEDFGITEKAFNEAFEQYAKGEDKNRVEFLEFVECIELLAKKISKMPQDLYNQLLSAEKPTQGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI96</accession>
    <name>A0AAV6UI96_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_001518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000393">
        <property type="protein sequence ID" value="KAG8183987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UI96"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031085">
        <property type="term" value="C:BLOC-3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026091">
        <property type="entry name" value="HPS4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14407:SF9">
        <property type="entry name" value="BLOC-3 COMPLEX MEMBER HPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14407">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME 4 PROTEIN LIGHT-EAR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8183987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="748" mass="84774" checksum="CCD6D858F256E61C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIU6</accession>
    <name>A0AAV6UIU6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000389">
        <property type="protein sequence ID" value="KAG8184067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIU6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14416" checksum="99D4D94759BB5E38" modified="2024-11-27" version="1">MRIKVLDSRKLKKHPLWADCTKLTLSVNMRALESEKQFSKWLLDASIAKEGDVVNLPEICYPEAQDPIAQLYNDIDFRNITSKQLKDRAILTVTNDISLKVIFFCLAQFYIKLANSEEIKRELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJ46</accession>
    <name>A0AAV6UJ46_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_001679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000405">
        <property type="protein sequence ID" value="KAG8183783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJ46"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051843">
        <property type="entry name" value="CPA1_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102:SF1">
        <property type="entry name" value="CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="7">
        <location>
            <begin position="84"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8183783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="503" mass="54691" checksum="764CF8BDDA87DDA3" modified="2024-11-27" version="1">MESSISKQTFDERHRNCVNEECNSNLAPESPAKCFRLTNERWKLVQAQFLTFILLLLFICASLYGILEEDILPGSELFALLLLALSAYISGVVANYVHLPPLIGMLIAGFLFRNLHVSAHLYENISIRWATTLRSTAFVIILLKAGLGLDADKLKKLSLTVFQLALTPCIVETAAAAVASHFFLGLPWVWSIMLGFVISAVSPAVIVPGLLNLQNKCFGTAKGIPTLVIAAASLDDIICITGFSVMLSVSFSEGNLLITILKGVLEPVGGLLLGVIFGRIFWHLPNSASVPSNLVYYRVLLLCFGGFASMFVSKRYDVAGVGPMACLVLAFVAAFGWKRDQLTFDRIEKVTGVLWTGLQPFLFSLIGSEVSIADLQFNLGNTILSLAIALGFRIVVATFVTFGSDLNIKEKIFIAFAWIPKATVQAAVGPQALDYVLSNSKGQEMEKYAQMVLTAAVVSIIMTAPVGAFLISVLGPILLSNDRNPDKQRSENMRLQTVDSDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKG6</accession>
    <name>A0AAV6UKG6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000385">
        <property type="protein sequence ID" value="KAG8184193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKG6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="112" mass="13172" checksum="D3C2B20EF3AB948F" modified="2024-11-27" version="1">MLQSWEEEATRYIASRPQQGAKFKTQMQEESKREKKRYMLQSWEEEEGRPQDISLLGPNKGPSSRHRCKKKASEKRSDICCSRGRKRKGGHKIYRFSAPTRGQVQDTDARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UL75</accession>
    <name>A0AAV6UL75_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000390">
        <property type="protein sequence ID" value="KAG8184036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UL75"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="167" mass="17767" checksum="AB28689A916821C4" modified="2024-11-27" version="1">MDSSAINNGMPGVYSGGPCGISIDAAARGEAWHCLSGVYFLWGEKSKDLAALMIPSNSDLKDGICFTFSSLPSSSSSEDQSAVRHAIGETRISVLKLSKAIKINESDPQSQLSPVSRKPLLSKTSQSTIAEVLKRPALCHSGLGTIDRTSRPPCHTQRDPIPPLPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULA6</accession>
    <name>A0AAV6ULA6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000354">
        <property type="protein sequence ID" value="KAG8184907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULA6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="576" mass="64312" checksum="2B2C6903B328E0F6" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMC6</accession>
    <name>A0AAV6UMC6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000356">
        <property type="protein sequence ID" value="KAG8184884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMC6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043630525" evidence="1">
        <location>
            <begin position="19"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="178" mass="20666" checksum="BDC6E71EB82C3CF6" modified="2024-11-27" version="1">MKNLCLVIVVVFCYTSSGFFGSSFELKCEYNQFLNGLNSTEKFFHGEVKTICGPTLRQNVCLNDTELEDANIGEYTKFRETYVWQQATCLKKNGRNLIMHSVSVDVDDYGYPEFLSAKCCQVDPTFREFSLFERESLFKENKNVNCELHAAMRSIRWRFHGDSYVVALDCSDERLYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMW6</accession>
    <name>A0AAV6UMW6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonucleases P/MRP subunit Pop8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_017061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000349">
        <property type="protein sequence ID" value="KAG8185038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMW6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8185038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="14438" checksum="806B5418ED00669D" modified="2024-11-27" version="1">MDVKLSQSSWFYMDIKLDFGENCDNSSLLMGVKQFKYAVFLALKTMHGDVGCAIPVDILKYDEKQRRAFIRIPSREVTKVWNSLLLFSSYEGLECMFRVYKVSPVLACLNMNSRLYNHKLSSNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UP08</accession>
    <name>A0AAV6UP08_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_028907</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000321">
        <property type="protein sequence ID" value="KAG8185909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UP08"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8185909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="204" mass="23517" checksum="8E788D0F1EC0AC09" modified="2024-11-27" version="1">MPSHLGLLVCEDQISFSDLSNIIIWSFCVGVQNVSIYDRTGYIKSNGSKLYKEANNRKNSILKKSANSLNIIFRDGKAPYLYNNFVRKNGHKTEDINVYLLSNLDGKQQIVSAAKSLCTDVKRKPHILENFHAQNFDCYLKDIINIPDPELLILFGESNGLMGYLPWHIRLSEIISQPTHYNFSIEEFQDILFRYSKCEQRFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ58</accession>
    <name>A0AAV6UQ58_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_000739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000325">
        <property type="protein sequence ID" value="KAG8185756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ58"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8185756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="160" mass="18606" checksum="393806C37CCB20E5" modified="2024-11-27" version="1">MGNTKGIKRGTRYMFAKKFRHHGVEPISTFLRVYKRGDIVDIKGNGAFQRGMPYKYYHGRTGKVFNVTPHAVGIIVNKRVRNRIIAKRINVRVEHIRHSKCRQDFLDRVKANREKKMAAKEKGIRVHTKRQPIGPLTSHFVSTKDNEPQLLEPIPYEFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQF4</accession>
    <name>A0AAV6UQF4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000294">
        <property type="protein sequence ID" value="KAG8186645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQF4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="173" mass="20227" checksum="F3F5A9A8198292F9" modified="2024-11-27" version="1">MLRLDIHVCQKSSKKKNLTIQPPPLSSEHRILLDNFSTPSFLISQRQRRFFAMHKAIIEARTTAVPRETCRGLNTSKQIGRKRQRNNAFPFSFFETDPGSIYQYSIPLGEEDLLLRRLIAKERGGFWVFRDTKRVGLLLLLSNELFFSFVFSGKVVNLRKRTDMLAFYVVYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQH3</accession>
    <name>A0AAV6UQH3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000297">
        <property type="protein sequence ID" value="KAG8186552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQH3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="171" mass="20034" checksum="4F5692204888E702" modified="2024-11-27" version="1">MDISEVTIFAEDLVMCLCRLTGIWWKPRSWLNKPRNVSHDKFTDRIGDVVYYLLLLHWRTQEACTPEVFPAGLESYNEYLFAEFFKYGYEAFNMLNYFAQLLSVGILYKGNYGQSDALDFCADAVEKAINHLAEAECIPLADIWNQLKQTAEKVDITYCQREPYFMWTYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6US16</accession>
    <name>A0AAV6US16_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_000392</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000284">
        <property type="protein sequence ID" value="KAG8186919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6US16"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="83"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="221"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="221"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="435"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8186919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="483" mass="53815" checksum="BB0F53D64D8FE2CC" modified="2024-11-27" version="1">MSHTIRILYEVAVPSYRSQNQLFNVLYNQVCFSQFRTYSKLSKLNRLQKSLCSKSTSSHGSHIYCSVKLFHTSNTHFARSRTDLYKVLGVSPNASQNEIKKAYYQLAKKYHPDTNKDESAAKKFQEVSAAYEVLGDETKRKDYDAWGTQTDNPFSSGGTGPSANEFRFHSNVDPEELFRSIFGNINFRQRMSDFDYAENDFGHGASEHVQLDLDFHEAARGCEKRLQVNIVDICPDCGGSCCLKGTKMVRCDHCNATGMETISTGPFIMKSTCRKCQGTGMFNRYPCPSCAGKGSCVQRKALLINVPAGVEDGQTVRVKAARQDVLVTFRVLESKYFRRDGADIHTNATISVSQALLGGETKVQGLMNEIVVQIPPGTASHKVFRFAGKGIKRTSGYGHGDHFVHIHIAIPTKLDGVQYNLIKAYAELEKNTPGTIKGIATPQKMKTNEFSGKNENNSDRKEKSEGKEEKKGILEKIRSAIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USL9</accession>
    <name>A0AAV6USL9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000279">
        <property type="protein sequence ID" value="KAG8187099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USL9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="107" mass="12413" checksum="7AE1390549AB326B" modified="2024-11-27" version="1">MLPRTFLSMDENTSGRAFLPSQNKTKTKKSCFLERDKRSIRSCSSCQIASVQFDIHASAAQEFFVLDRSNNPFFCPIKTSSRFCNTQEESELVFCSVLWQFYCDREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UT05</accession>
    <name>A0AAV6UT05_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000272">
        <property type="protein sequence ID" value="KAG8187476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UT05"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="567" mass="64728" checksum="3B6A28380D69F8CD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTX0</accession>
    <name>A0AAV6UTX0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">UBX domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_000171</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000262">
        <property type="protein sequence ID" value="KAG8187705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTX0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16117">
        <property type="entry name" value="UBX_UBXN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="UBX" evidence="8">
        <location>
            <begin position="324"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8187705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="510" mass="57237" checksum="E5ACF9D10F92CBA1" modified="2024-11-27" version="1">MMKLNLFKENLHTKILYLKYFRQKSEFKNILILAKETMEWYSGSIPEAVNEAKRNNKLFLVYIEGTDDMSKSMTDSYNDPGVAGKLSSQNIVALKLAANSVPYQQFSQIYPVLVIPSSFFIGNGSPIEIITGSLPPDKFSNKLDQVFQMYEKTLGAKKEAGSSKNPVASTSKANDVPEPSVSQAGSSSNEPSTSQTETASDSSQLLQDKVERAKALVEAQRLKKAQEEKEKEKQEEIQRRTMGKAIQQAEQTKQDKEMQEWAKNRAKEKEEERLAREKVKAMIAQDRAERAAKYQKTKEVEQAEKERAAKSREEAERSMRSAAMNSNEARIQFRKPDGSCSTHSFSADATLADARRFVIEEVRPPFSNFTLCTTFPRRHFAESNYSESLRDLQLAPSAVLLILPAQDVSVSNNGGFLANLFWMVLSPFQGIWNLLRSLWPGGSPEAPPPQPTPPSQPQPSTSKESPDNSRPKTGPRPSSFAKREGNIFRINNQSDDDENNTWNGNSTQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUW0</accession>
    <name>A0AAV6UUW0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_025747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000253">
        <property type="protein sequence ID" value="KAG8187979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043888129" evidence="3">
        <location>
            <begin position="28"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1926"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1286"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1607"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1757"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1294"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1305"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1616"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1763"/>
            <end position="1776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8187979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2060" mass="231917" checksum="5A7C972D8678CDFE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UV90</accession>
    <name>A0AAV6UV90_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-gulonate 3-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">L-gulonate 3-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_029042</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.45" evidence="8"/>
    <dbReference type="EMBL" id="JAFNEN010000248">
        <property type="protein sequence ID" value="KAG8188114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UV90"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050104">
        <property type="term" value="F:L-gulonate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000356">
        <property type="entry name" value="Lambda-crystallin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004783">
        <property type="entry name" value="PRK06129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF1">
        <property type="entry name" value="LAMBDA-CRYSTALLIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="12">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="190"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8188114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="323" mass="36384" checksum="DBFE650CD87B1A5D" modified="2024-11-27" version="1">MAGKGKVGIVGSGFIGRGWAMLFASVGYEVKLYDVESTKIDDALADIQLQLKKLEDTGYLRGKLTADQQFSLIQKCETLKECVEESVHVQECVFESVDLKKKVFKDMDAFASENVVLCSSTSCFPASSFSEDLVHRAQVIVGHPVNPPYYVPLVEIVPAPWTDPEVVVRTRSLMTEIGQKPVVLRKEVPGFALNRVQYALIDECWRMFRDGIMSLEDIDTSMHEGLGLRYAFLGPLETCHLNAEGMLDYCKRYGEGINKVSETFGPNPRTEGELAERVHEEICKISPLEKLAERRQWRDARLTALAQMKRILEEQEKEAETVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVT9</accession>
    <name>A0AAV6UVT9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000260">
        <property type="protein sequence ID" value="KAG8187778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVT9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6570" evidence="1">
        <location>
            <begin position="225"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="376" mass="43349" checksum="205233710E509BE7" modified="2024-11-27" version="1">MPPTCLVNELYIEPVPEEIISLNYHEKLLIQRAKALQTVIKMGTVSCKNKPRSFLNQKVVGKTFHLPLPLEKTLERLPKPEQAIITDQDLSSLKLLYDITRANKSINEIQEAICTSDVDSLQVFSKEYKKIGNSFVVHGVKYLNEDEISAKYHKGLMSLKRRITDTPSHICMSCHKLHYKRDVKDMRKLRIPLDGDMWKKVAKFVNDHGLPSEYICTYCLAYFRRQKMPPTCLVNELYIEPVPEEIISLNYHEKLLIQRAKAFQTVIKMGTVSCKNKPRSFLNQKVSGKDISTPIPLEKTLERLPKPEQAIITDQDLYVIVRGIPTNQKKLWQSLVNLSSVNKALKWLKQNNPLYTKIVLPISDHNLLDQLRDTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXC5</accession>
    <name>A0AAV6UXC5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Plastin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_019007</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000224">
        <property type="protein sequence ID" value="KAG8188995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXC5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21292">
        <property type="entry name" value="CH_PLS_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21295">
        <property type="entry name" value="CH_PLS_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21298">
        <property type="entry name" value="CH_PLS_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21301">
        <property type="entry name" value="CH_PLS_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000031">
        <property type="entry name" value="Fimbrin-2 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000263">
        <property type="entry name" value="plastin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000066">
        <property type="entry name" value="plastin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="125"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="269"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="391"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="512"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8188995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="71061" checksum="4AED0721A24CAE43" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0E7</accession>
    <name>A0AAV6V0E7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_019069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000218">
        <property type="protein sequence ID" value="KAG8189311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0E7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF3">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXV) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8189311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="244" mass="24860" checksum="E32D199D77DFBCC9" modified="2024-11-27" version="1">MSKTSIKLAIRRAVTTDPLNQFLNDNLKAALRAALRHSGTSGQAANTGTWRQAANTGTWRQAANTGTWRQAANTGTWRQAANTGTWRQAANTGTSGQAANTGTSGQAANTGTSGQAANTGTSGQAANTGTWRQAANTGTWRQAANTGTWRQAANNGTSGQAANTGTWRQAANTGTWRQAANTGTWRQAANTGTWGQAANTGTSGQAANTGTSGQAENTGTSGQAANTGTSGQAANTGTWDKLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0N3</accession>
    <name>A0AAV6V0N3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_008502</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="JAFNEN010000213">
        <property type="protein sequence ID" value="KAG8189542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0N3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF39">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="11">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8189542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="10294" checksum="00BB2E9DB86CE6A4" modified="2024-11-27" version="1">MQLCVVWSTNCIAFRCQTCAYSPYMTLYTQCFHEGDHEGHEFKMYRSAGGFCDCGDKNLLRETGFCPRHGLYDEPNPLPGLFAKLSNKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1J5</accession>
    <name>A0AAV6V1J5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000178">
        <property type="protein sequence ID" value="KAG8190632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1J5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="8070" checksum="26C90650DA876320" modified="2024-11-27" version="1">MYLRYSVPKTPDTKDSHIFLRDKCLLSVSAEMSRSHYRARNASSSDHLRRRSVKSVIVICGRDRLGIFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1L8</accession>
    <name>A0AAV6V1L8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000178">
        <property type="protein sequence ID" value="KAG8190630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1L8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="121" mass="13649" checksum="2C5AAC9F6B6E8055" modified="2024-11-27" version="1">MLPNHIRWGRLVTHTPHVAEVRRYVTKPHSHGRKDPSLITPHVAEVRRYVTKPLQMGGKDPSPITPHVAEVRRYVIKPHQMGGKDPSPIAPHVAEVRRYVTKPHQMGGKDPSPIAPHVDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2D6</accession>
    <name>A0AAV6V2D6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_008701</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000192">
        <property type="protein sequence ID" value="KAG8190168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2D6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19343">
        <property type="entry name" value="Wnt_Wnt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF102">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8190168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="376" mass="42054" checksum="D67C758436CB8F04" modified="2024-11-27" version="1">MGVTCGADSPCRDVGWLVRSPEIYRNMRCLRILIIATLALTPTTAVHWIALSKWRQGWNKSSQCLYAKKHSLLKGRQVSLCQKHIEVMSHLVSAARDATNACLSAFSDMRWNCSSIKFAPYLTPDLVKGTREQSYVYALASAAVAHSIARVCSDGSLATCSCGALPHEPPHGDFKWGGCAHNIKHGLKFARNFADAPWRQKAVRKNVEAAVNRHNNQAGRRAVRSSLQTDCKCHGVSGSCNIKTCWKALPRLADIGERLKRKYYIATEVKQRQIGSKLKLMPANGKLSMYQKNDLIFVAKSPDYCLRDDRVGSPGTHGRICNNTSTGTDSCDSMCCGRGYRTFTMESFSRCQCKYYWCCYVKCQVCRTWVNAYECN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V391</accession>
    <name>A0AAV6V391_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000172">
        <property type="protein sequence ID" value="KAG8190867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V391"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="194" mass="22052" checksum="03BAEA005EA14E05" modified="2024-11-27" version="1">MGTCFGSCSKKLMRKTNCKRKFVLIRTSQEHNDDEEFLEMEQRNVATIESPQRSCPEVYETNKPSKISFPSKKGNFTWLRNENQMISGALHHIRNMKSPADSVMPLLNRESSYAETISNSGSHKWDQLSRGATPNSSVDLEWENEIGFNSSNNLGAMEEPQWTVLTENTNTNNSHRSSPLSNSNGLEWDGDFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V481</accession>
    <name>A0AAV6V481_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000185">
        <property type="protein sequence ID" value="KAG8190411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V481"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="13743" checksum="E6F11AFFFA0D8593" modified="2024-11-27" version="1">MNERTRANIHSKRMTVPSTNLKNREIGEAGERCRAESQEVLSGLEQILLEESLPLTVGMLVTVLSCLFFSECSRSAQTALTRLSSGHIKSLKFVDRVKTYSSFPCSYPASSAHVIECIGASMGQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V514</accession>
    <name>A0AAV6V514_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_024860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000175">
        <property type="protein sequence ID" value="KAG8190726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V514"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="232"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8190726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="643" mass="74776" checksum="A9591FC8E17CBCB8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5B2</accession>
    <name>A0AAV6V5B2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger protein 830</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Coiled-coil domain-containing protein 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_014382</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000171">
        <property type="protein sequence ID" value="KAG8190901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5B2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059039">
        <property type="entry name" value="ZNF380_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23406">
        <property type="entry name" value="ZNF380_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZNF380 coiled-coil" evidence="16">
        <location>
            <begin position="163"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="33"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8190901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="281" mass="31219" checksum="D6C5576DA4B05B2A" modified="2024-11-27" version="1">MYNSIGQLSCTICNVYVKNNNLWGPHVAGKTHKENLLKPKKSNTNENSVKTAVQSKSTNRNLEQENSVKKLKSNDAASLEQPQSSKKVSLLASYSSSDESDDDNGSETSLLSKGSVSNTLPPDFFDNNAAAAGTTDVPSQASQSAQSEKQENGPEPSSNVETLPEGFFDDPVLDAKARNIEYKDPVEEEWEKFQKTIAEETNVSKTLMEEDFEERTLERDIDQIDEQIQQWERVKNLQVKADDVKVTAPPKNKNDGDSGTSDDELQEDDLLDWRSKGVKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5T9</accession>
    <name>A0AAV6V5T9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">JTE90_001733</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000147">
        <property type="protein sequence ID" value="KAG8191997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5T9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF41">
        <property type="entry name" value="INNEXIN INX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8191997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="373" mass="43160" checksum="896EB93C7CA679F8" modified="2024-11-27" version="1">MLTLFTNLKGLLKIRTICTDGPVFRMHSRWTVLILLVCSILLASRQHFGEPIHCLQRDVSRIKALENFCWIHSTFVMPHAWNATVGVEVPHPGIDRHVPGKPKVYHGYYQWVALALLLQAILFYLPRYLWKTWEKGTVKALALNLHDPLLTDAEKEKSLTLLVRSLNLHWGHFDAYFRKYLFCEVLTLVNVLAQMWALDVFLDGVFTTFGIKVLQWSDWDQEYRNDPLVRAFPRMTKCQFYDFGSSGDVQRVDALCILPLNVLNEKIFIFLWFWMVLLLVLTGVTVFFRLMLAAMPMLRYCVLVTRAPQASKGALDRLVGRCRTSDWFVLYLLAKNIDSRHFSAVVSKLAAAMDQNGIHRPSTSRDYTKLTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V681</accession>
    <name>A0AAV6V681_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_027790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000144">
        <property type="protein sequence ID" value="KAG8192147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V681"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8192147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="215" mass="25152" checksum="39421A390AF734D3" modified="2024-11-27" version="1">MSNPPFNKENTPNVDVFKDQHNFVTNWAVSEILSFQVAKNRANLISFFIKLAIELHKMNNVNSLVAILVALRTTAIHRLTQTWELVPKALKIKFEKLCHLIESDFNMTELRRLQDDMKIPCLPYIAGYQSDVIKVEEMLKKFPRGEAEKAELCRKQMLKIFFPIQKCQNSNYDHLKKNPLIETYFNVIGEKLDIFKMTAQEQNNFTFRLSKDVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6N6</accession>
    <name>A0AAV6V6N6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Shootin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_017940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000139">
        <property type="protein sequence ID" value="KAG8192405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6N6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044295">
        <property type="term" value="C:axonal growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031252">
        <property type="term" value="C:cell leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001224">
        <property type="term" value="P:positive regulation of neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024849">
        <property type="entry name" value="Shootin-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46606">
        <property type="entry name" value="SHOOTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46606:SF5">
        <property type="entry name" value="SHOOTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8192405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59542" checksum="BF7984D8E44FACDF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6V7</accession>
    <name>A0AAV6V6V7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-binding cassette sub-family F member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_016454</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000154">
        <property type="protein sequence ID" value="KAG8191664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6V7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000471">
        <property type="entry name" value="ATP-binding cassette, sub-family F (GCN20), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000472">
        <property type="entry name" value="ATP-binding cassette, sub-family F (GCN20), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="55"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="376"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8191664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="605" mass="68409" checksum="B75F2E32722955E5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7L6</accession>
    <name>A0AAV6V7L6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_008782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000153">
        <property type="protein sequence ID" value="KAG8191718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7L6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043406289" description="Lipase domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8191718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="365" mass="40336" checksum="D63633580A45B4DC" modified="2024-11-27" version="1">MWISLAAYVQILFKCIQIGETAMSSEFPEKCYPTLGCFPTGPQFYDPPECADSPLPFDLNYIDTDFLLFTTSNPKNPITFKFDNQSLPELPFDKKLDTKVIVHGYYSLLPQNSSYHEMKDALLKQGSYNVVLVNWTSSNQPPYTQAVANARVVAAQLAHVINTLEITRGLQPSLVHLIGHSLGAHLVGFAGKRIKGFGRITGLDPAGPCFRKADSGRLHSGDAVFVDVIVTNGASYKDQGSGLYESVGDITFYPNGGRQQPGCEPPEGTPQKDRQSYINDCSHLRPVDLFTSSVVEKCRFEALSCCDYQDFTSGNCSSRLLMKKCKCSRPIEARMGLYAKKSKLQRPGERFYLSTSGSPPFCTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEP7</accession>
    <name>A0AAV6VEP7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEP7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8280" checksum="6D5C5F4CC45AF097" modified="2024-11-27" version="1">MVVYMYPCQAGHYIKQTRCDNDIITINKKGWDDVKDVLNEDVNVRDGGGALFSSQGANSSAEMKRKRRQIAGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEZ3</accession>
    <name>A0AAV6VEZ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_029646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000094">
        <property type="protein sequence ID" value="KAG8195067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEZ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8195067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8346" checksum="A668E31E913D3940" modified="2024-11-27" version="1">MWLPTPCNTRKFTDSKNVTSDPQHPTNQKKASNSQHLVLLGMSVTAMWNHLVELKKMKRRRRDGESGEENRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF90</accession>
    <name>A0AAV6VF90_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_028457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000090">
        <property type="protein sequence ID" value="KAG8195310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VF90"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043652902" description="Secreted protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8195310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7786" checksum="A2F427CE13A1AD8F" modified="2024-11-27" version="1">MPTSVLCRIFVIVCYSLQFLNFQVNSFREEKLNQYVVPLLVSFSPQTKSIVSSPPLPRRITRQRGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VH16</accession>
    <name>A0AAV6VH16_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000075">
        <property type="protein sequence ID" value="KAG8195959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VH16"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF9">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="328" mass="38118" checksum="E33EDDCB0C20067C" modified="2024-11-27" version="1">MVPFIGNKNIVVNFKKCHSFTVINNAVVSDIDESLTCPDHEEADTKIIHHICNIDAQSNFVIRCSDTDIAAIMLGNMRHLKHSESHVWMLIGVGNKVRYVDITTVYEQLGPSLSRCLPGFHAITGCDYNPAFFKKGKQRPFNILKKNEEYQKAFMKFGDRDLFCDLEIQENVFNVIQKFICEVYNLTGITNVDAARLQQFIDNYMVYDVNEEFNRENVKSFDASNLPPCKSELLQQFCRANYITGLWINSYKKELRIFNPENNGWTLEDNHYHFNWFDGDQLPGFVSESLQEESEEDTKDDDNDNEYIQHQHCIDDELSNFNDEDNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VI12</accession>
    <name>A0AAV6VI12_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000079">
        <property type="protein sequence ID" value="KAG8195763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VI12"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="11097" checksum="3E0E48BC9BCEDEFE" modified="2024-11-27" version="1">MSLPPTIKSETLVPYKDNFESQNPPSSYRLQSRSNSCNRKTPNTPSPRRESTSFLPNPKNPALAYPEGNRPLAITLGNHFPIVFSNSVPEKPRNFISGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIE2</accession>
    <name>A0AAV6VIE2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_008540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000077">
        <property type="protein sequence ID" value="KAG8195848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIE2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="242"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8195848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="529" mass="60208" checksum="F4FEB0043BC39633" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIJ6</accession>
    <name>A0AAV6VIJ6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_002998</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. AMIGO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000080">
        <property type="protein sequence ID" value="KAG8195737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIJ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031283">
        <property type="entry name" value="AMIGO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24368">
        <property type="entry name" value="AMPHOTERIN-INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24368:SF210">
        <property type="entry name" value="SURFACE ANTIGEN BSPA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8195737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="226" mass="25784" checksum="0E3C77DE93343DF6" modified="2024-11-27" version="1">MGHPGPRLRILPVGNSTLNDESVSPHTTIRRSQLHDALLTWDVYSTLVHLKKFNVDNVFIKKIDEEFVRNFPQGLTSLNFRQTKTKRLGDDAFANLANLELLSIRDTQILELKRSMFPPVSKLMSMQFSGNQISSLPDDLFTNMPDLVWVDFSNTNVVTLPESVFGRIMPQLSVLSLEGNAVNCNCQMKWIPKLEMPPYGVKCTKPRELEGRTLKTLKEDHFLHCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJ30</accession>
    <name>A0AAV6VJ30_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000083">
        <property type="protein sequence ID" value="KAG8195626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJ30"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="120" mass="13783" checksum="C28A11EC1C0B41C2" modified="2024-11-27" version="1">MNRSIDIDSMTDSELERAYLDSKNKLFQATQQIHQLDSQISYLRKLFRRAEKNNGYAVRYNLRMQLSISSGVKVMYHHYAVMLEKRISNIRSKINLPESSSSSSQSSSTSDEAVDDSIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJV4</accession>
    <name>A0AAV6VJV4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Exostosin-2</fullName>
            <ecNumber evidence="6">2.4.1.224</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">JTE90_028952</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.224" evidence="6"/>
    <dbReference type="EMBL" id="JAFNEN010000075">
        <property type="protein sequence ID" value="KAG8195978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJV4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050508">
        <property type="term" value="F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000035">
        <property type="entry name" value="Putative Exostosin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF5">
        <property type="entry name" value="EXOSTOSIN GLYCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="21">
        <location>
            <begin position="86"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="22">
        <location>
            <begin position="439"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00069568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG8195978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="701" mass="80358" checksum="12D00A4D160BCCA2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM05</accession>
    <name>A0AAV6VM05_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase-coupling factor 6, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_007253</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ATPase subunit F6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000054">
        <property type="protein sequence ID" value="KAG8197515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM05"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.110:FF:000001">
        <property type="entry name" value="ATP synthase-coupling factor 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.110">
        <property type="entry name" value="Mitochondrial ATP synthase-coupling factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008387">
        <property type="entry name" value="ATP_synth_f6_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036204">
        <property type="entry name" value="ATP_synth_f6_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12441">
        <property type="entry name" value="ATP SYNTHASE COUPLING FACTOR 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12441:SF10">
        <property type="entry name" value="ATP SYNTHASE-COUPLING FACTOR 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05511">
        <property type="entry name" value="ATP-synt_F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111357">
        <property type="entry name" value="Mitochondrial ATP synthase coupling factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8197515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11372" checksum="ADE06ED29BA4F9A0" modified="2024-11-27" version="1">MASLKALKCGNLLKNSLNTYRNFGVCSVLMVNKAATDPIQKLFLDKLKDYTKKSSGGKLVDITPEKQREYDEQLLNLKKSYGADKGQDFTKFPTFNFVGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMB8</accession>
    <name>A0AAV6VMB8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UNC93-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_001565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMB8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF11">
        <property type="entry name" value="UNC93-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8197635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="61296" checksum="123F1492CF15AA58" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMR1</accession>
    <name>A0AAV6VMR1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_004285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000059">
        <property type="protein sequence ID" value="KAG8197013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMR1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8197013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1094" mass="121899" checksum="5DFA597B7BDB41D3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNF7</accession>
    <name>A0AAV6VNF7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_007504</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNF7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8197253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="469" mass="54475" checksum="87840D5555D4FACC" modified="2024-11-27" version="1">MNLWPNFKKILKNSVITGVPQIVATKNNFRKILKTYVFFVCVTGFFWQTFTFLSVYWTYPTVVDVQYYFPDDFDLPAVTFCSSNGIKSSMFCQRFSHLCYPNSSLEEFCTNHLLLCDPNNNFPENVSFPTVAARELPLLSRREYQKMGLQPQEMVTGCVVYESPRVTDCTLSYEVVNVFDTKGLPTNCYSYNSLWGKVEGARQIKTKTVLLFTMKSERYQTNQFYTGTPYAIQVAIHSPYMLINPFMNGFSIKPCSNYYIFPTMQKNVLLPPPYTSSCYNYTATWIERSGRGPRNKRLCSEECYLNKSLEKAGCVDPFFVTYPNMERICKEEAHFSIYDECRNQCRPACEREDFSADVQEHAFLRSKPRGKEKGNECVSTIMISFNRMEIVQYTYSPKYESVSLFSYVGGYLGLWLGISLVAICDAIETLLLLLQWLWEKIRRHIKNRRLVNVKPNRKTNNVQGQLFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQI0</accession>
    <name>A0AAV6VQI0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Myosin heavy chain, muscle</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_020917</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Muscle contraction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000044">
        <property type="protein sequence ID" value="KAG8198092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031033">
        <property type="term" value="P:myosin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000036">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000008">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000002">
        <property type="entry name" value="Myosin heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000019">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000021">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000025">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000009">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000010">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000024">
        <property type="entry name" value="Myosin heavy chain, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000050">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF27">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8 14" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="18">
        <location>
            <begin position="32"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="17">
        <location>
            <begin position="85"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="676"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1997"/>
            <end position="2026"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="916"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8198092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2026" mass="232098" checksum="DA0712210344FBF3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSQ7</accession>
    <name>A0AAV6VSQ7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000031">
        <property type="protein sequence ID" value="KAG8199115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSQ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="9715" checksum="AF6F1583E9C3396F" modified="2024-11-27" version="1">MGITIKPARKPRLPPHPATANCQVTMRGISSSATLHPMLLTRPSFGLSMQGCKKGSRCLDQHTPYSISSVSIHLSISVVESLPVRMCGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTZ4</accession>
    <name>A0AAV6VTZ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Suppressor APC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_024959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000018">
        <property type="protein sequence ID" value="KAG8200174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTZ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.450">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026828">
        <property type="entry name" value="SAPC2_1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057953">
        <property type="entry name" value="SAPC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14907">
        <property type="entry name" value="FI14130P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14907:SF2">
        <property type="entry name" value="SUPPRESSOR APC DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25825">
        <property type="entry name" value="SAPC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11414">
        <property type="entry name" value="Suppressor_APC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor APC" evidence="3">
        <location>
            <begin position="10"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8200174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="474" mass="53988" checksum="8D4D1AE50979267D" modified="2024-11-27" version="1">MTSKSTLDALPKPFVTAMRTLFDVMDDKRTGYVRLADIEKRWTEENRSGTGGGLPNGVVDSLRKVTPANGLLTFERFCAGLRICLLRHDSSKRSHAHNNVPKSSRPSSVPLPERGNSIVSMRKPSTPLGKMIHTSTSAERLPVGVLSSASSRLVRQHNQQHHNNTATVRPNNVVNPFVQQRAISMPHLQTGIKTYQPLPKLSPSTWNNKKDGAKRIEPLDRNKVSLALEKWRMMKSYHVPKEHQENLRPLRSLNLMNSSSYPSLPNDQVSSSDVDSGVSLRPPQDRGPAAKKASRRREPRRHTVSNGIDYNMIKRLKLLEQEKDFLLQGLDVVDRARSWYLQQISNVSDKLERVSKWDIPHSEYSMDAQHERLNFQMTRISEVNHHLNALMETSEKGFPIHMNLAVHQRNIYGTQKAATQTIQRLKNQNHALTEEIGKKSEMITQLETEKSALIRELFHARTFPKKEPNDTTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWF5</accession>
    <name>A0AAV6VWF5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000019">
        <property type="protein sequence ID" value="KAG8200147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWF5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="126" mass="14174" checksum="EA817A007E6AE367" modified="2024-11-27" version="1">MGLTKDVAAKKVAAKEAGRKTRRVRFETVKAEKMLKEHRSRATRPVQKKDEYMKPGCSTNSMIVDRVHREIKTSPGSTYVTAASYSISGDEEYDDGDNHDQEINQDQLETREICPGSDLSKAKVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWH4</accession>
    <name>A0AAV6VWH4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWH4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10407" checksum="088E5C2F67A8F5A1" modified="2024-11-27" version="1">MSCCTLPTPNPTRHTVRTQCKSDLSRVKVFSRALALHPDQTWTEGPTPILLRRNRKIRLIFSEGDSPLATITAMQTNHKQWNGSWERADSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZY0</accession>
    <name>A0AAV6VZY0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_024295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZY0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000036">
        <property type="entry name" value="septin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="41"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8201422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="425" mass="49090" checksum="4696EE8BFC0B78CA" modified="2024-11-27" version="1">MAAAEVERAVGVTENFRGLKLQGHVGFDSLPDQLVKRSVQEGFAFNILCIGETGIGKSTLMDSLFNTTFESAPSPHNLPGVKLKSKIYDLQEKNVNLKLTVVDTVGYGDQINKEDSFKSIVDYIDSQFEMFLQEELKIKRSLVTYHDTRIHACLYFISPTGHGLKSIDLVCMKKLDMKVNIIPIIAKADTISKVELQRFKIKIMSELVSNGVQIYQFPTDDETVSEVNSTMNALLPFAVVGSTDFVRIGNKMVRARQYPWGTVMVENENHCDFVKLREMLIRTNMEDMREQTHARHYELYRRMRLEQMGFSDVGADNKPISFQETYEQKRQEHLQELQRKEEEIRQMFVERVKEKESELKDAEKELHAKFDALKKQHAEEKKKLEEDRKKLDDDINNLNKRKQAVQQVQTQVPFQSLTLGKSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W127</accession>
    <name>A0AAV6W127_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W127"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="216" mass="23835" checksum="67B39BEF9CE9A345" modified="2024-11-27" version="1">MQQQEAFKYNLCNTLNIGQDKETKEQLQIPQASSQASLPERTPPLKPAPAQTASLPERTPPLKPAPAKTASLPERTPPLEPAPAQTASLPERTPPLEPAPAQTASLPTSEETTPPLPITATESTAQAVPEPSFSFLETFLPSSQPERIMEKFQIDPSKLEMAKKKSVCGFRCNAKKESVTRKALTLEKLDFIKDKFKERISAERVADPELETYCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TES9</accession>
    <name>A0AAV6TES9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006117">
        <property type="protein sequence ID" value="KAG8156254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TES9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01213">
        <property type="entry name" value="PTB_tensin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013625">
        <property type="entry name" value="PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033929">
        <property type="entry name" value="Tensin_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051484">
        <property type="entry name" value="Tensin_PTEN_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734:SF10">
        <property type="entry name" value="BLISTERY, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734">
        <property type="entry name" value="TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08416">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTB" evidence="1">
        <location>
            <begin position="47"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8156254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="140" mass="15491" checksum="5E131CDAD331E898" modified="2024-11-27" version="1" fragment="single">SLSALVYQHSITPLALPCKLVLPEQDPGLETDEHTSNNDTLLEQGAACSVLYLHSVDMESLTGPQAVKKALTEMIALKPRPSAVPVHFKVSNQGITLTDNSRKLFFRRHYPVKSISHCGLDLEGRKWTQTNDDGVPINTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGY0</accession>
    <name>A0AAV6TGY0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004707">
        <property type="protein sequence ID" value="KAG8170901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGY0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="284" mass="34446" checksum="C933C6603B9E5513" modified="2024-11-27" version="1">MKKRAKIHQTKSPTNEKNNQRKQTERPNTDYSSKKGTRINTKQNKPNTESQQTTDPHKTPTDKERSSRKRKNPKRESPRRGERQTSTTPTTAIENRQETQQQKRQAKAEKSKHTRERKRKRKSAARDKTQTKKTEEKEKPTRTKKTQRKRRNKREKRRRKESNRKEQEERAKKPQNQRQQQTKRQARTKATRKKKERKDQKEERNERRQRGTKETRSTERRRKERKKHKKRKKQDTNQPKRAIQTTESTGQRKQVIDNQEQQDSKKKPTAKDKSQERKEESTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THJ0</accession>
    <name>A0AAV6THJ0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004294">
        <property type="protein sequence ID" value="KAG8171212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THJ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="147" mass="16449" checksum="E872BBF85BA6A8E9" modified="2024-11-27" version="1">MFLRFRKKPFHIEGPTTIKGPLYLILPQKYCHKIKYTKTSHSRQTVLDFTTNPALHIGAGEETTRVERTQASRVGHGAQRHSTHTQTAARSYDHNMSPYSPEIISAMEGGRHGGPGPPQKANVREAGPDYKTRAPPFFPRTQTCAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIE2</accession>
    <name>A0AAV6TIE2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003806">
        <property type="protein sequence ID" value="KAG8171574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIE2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20614" checksum="966F290804F75ACD" modified="2024-11-27" version="1" fragment="single">MDEYETESGIGRFAVPKFNGSDYRRWSAKMRAALMGIGAWRIITGDVKYPGESASPKELQSYQRVNEKGFALIYTCPEERYQMLLDDETCCNAAWKLLKDNFDMDSRARLVRQLDEFFSIKFEPGEETIGVQFDYFNGQILMPQTNYTNKMKEIYASVPMCHRRVPMRGIVVENVKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TK43</accession>
    <name>A0AAV6TK43_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003152">
        <property type="protein sequence ID" value="KAG8172078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TK43"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="150" mass="17242" checksum="DE1768AD292A5497" modified="2024-11-27" version="1">MFRLYLTRTNGPPIVIKADTDLLNFQFNDIQRDYISPWTLNSFSYPDNSIPQDAIAYSIRGIDQVLPLAARIIMDLNKPVACVDTATFYALINALPKEFDLGYIHPSRIDFSDLYNPVEVGRNVLQQLEKEQERCDRLNDDDDDVVILDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKE5</accession>
    <name>A0AAV6TKE5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002901">
        <property type="protein sequence ID" value="KAG8172269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKE5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="211" mass="24230" checksum="0B1BB512D9E9A5F5" modified="2024-11-27" version="1">MEIEPDVKICNEQESFLAEIPDCTLLGANAIYHEPRSAWYSEDDGIDDELTTWKPEYVDFGIDKPRESSLNDEKTSLDAKPDDALSNAREILRKINFGKKRSQVRNEYGKHIMTFVNIEQPVSSIEPEDMCHVTIRTQLEKTTRSQSYASLSQELTNSLDSRQPRTVSLCSWHAVMPPPLVRQFLQLMHQLREARIGRLNIEPMENPPGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKT0</accession>
    <name>A0AAV6TKT0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002849">
        <property type="protein sequence ID" value="KAG8172296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKT0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="160" mass="18138" checksum="0020708112C64290" modified="2024-11-27" version="1">MPDALCNLHNLHNIRLAGVFRKVTPFLHSITWRIKTQTSVDDTRNAIAIPPRSPDPSNNVEIQARRRIQNRADELRSSSTGSVSSDPDDVIEVTDIIGGYGPWQRDIFVLLFLASIPSAWHNLQMTFMAPSRSRFQVHHAPAPECQWWRRGGTLACRLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLP0</accession>
    <name>A0AAV6TLP0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002532">
        <property type="protein sequence ID" value="KAG8172613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLP0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9916" checksum="C7E6F1A81DC357EF" modified="2024-11-27" version="1">MGITNFCKLIDPLHDPKPPNKPAPFDSILFDVQPFIHAGIASALESEESKLILEVCRVAWYKLHKQLLQFLPFATNDSLKRVEIPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLQ4</accession>
    <name>A0AAV6TLQ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_021269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010002519">
        <property type="protein sequence ID" value="KAG8172628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLQ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="7">
        <location>
            <begin position="65"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8172628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="170" mass="19794" checksum="58AE42BAED083F4C" modified="2024-11-27" version="1">MLYCMKEFVQIPIRQKRNEDSQLPRKYMTLEVSWDCSYYRRFIPNFCHKAQPQQELLQKDVTFAWHQEHQASFQELKTALTSDPVLGLYDENAKMELHTDASGYGIGAVLVQIQDGKERVIAYASRTMSKAEINYSTTERECLAVVWAVNKFRPYLFQTPWLLITTLSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TM51</accession>
    <name>A0AAV6TM51_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002305">
        <property type="protein sequence ID" value="KAG8172854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TM51"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7933" checksum="1171091978129AD9" modified="2024-11-27" version="1">MDTCRSYTCYSGRQRLIIRVRVSSSRIGECFTESSAFRMAEDHRIRYHEASCPRITSLCSCRYNGFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMD0</accession>
    <name>A0AAV6TMD0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_005601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002209">
        <property type="protein sequence ID" value="KAG8172952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMD0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF105">
        <property type="entry name" value="LACHESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043518311" description="Ig-like domain-containing protein" evidence="4">
        <location>
            <begin position="29"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="37"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8172952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="166" mass="18551" checksum="477E7246658953BD" modified="2024-11-27" version="1">MINAKLLKRLLLNFLICQCFISVKLVVAEYENWKIQPFIFPPKLTVGTRATGVCSTTTGKGLQFQWMKNGQNIDKSPNVQIRSYTDSSMILIDPLTEDDSGNYTCVVKSDFWTDSFTAPLVVLISPTWVKIPLDADVLAGEDVTLPCHAVGKPDPVVQWQNSSNHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNB8</accession>
    <name>A0AAV6TNB8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001830">
        <property type="protein sequence ID" value="KAG8173374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNB8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7118" checksum="1F1FB1992826595B" modified="2024-11-27" version="1">MLNLVSIGASLSCSINNNSTALSPHSSEPPLASIACRRQVEPNQYEHPNATGTLTFPTTKLLPQKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNW1</accession>
    <name>A0AAV6TNW1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001895">
        <property type="protein sequence ID" value="KAG8173294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNW1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="260" mass="29121" checksum="95CF52C13A0B13D3" modified="2024-11-27" version="1">MSSRSDCIFPRPVDIVAALDSSKDYWIAHLLQVMAYVSHITGEGDRIYHKPLDKNTFIKGKGLEHLKFCLHAVLGEVPFDSRQLDRTWDSIGRRLRRDPSRSLSNSNVCLLFKLHNMFLVKKGFTFGNWLVAEDEQHVIQTSNAAMMCFVLPENSDPCPGKNEAPFAGELSVVLRPIRSPSTRHLPRSPKHPIRVGGRPKDHLCFGRHLFGISFPRSHSIRCLQTLLHAAGGIQRATSDTLPISRTTALDDDAATTSEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNY6</accession>
    <name>A0AAV6TNY6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_012987</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001528">
        <property type="protein sequence ID" value="KAG8173712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNY6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8173712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="151" mass="17501" checksum="9DA36DEF5C90EB33" modified="2024-11-27" version="1">MDAGELLSGHLGIKDENTARSSNKKLFRLLKISILACCLTGFGLQTAEFLDNFYKYPVVVSLEYQRMKEFPIPAFTFCSKYWYDFKQYCQEFPDNCETTEYPKNFCDSYPWSCERNATHGIMPTTFPDFYFDKNILKRIAYTSSMASLAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPG8</accession>
    <name>A0AAV6TPG8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001562">
        <property type="protein sequence ID" value="KAG8173663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPG8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="199" mass="21942" checksum="94A2A92504CC1EA0" modified="2024-11-27" version="1">MPSKTVAGIALSAGKTFVFIPVFQKPDTRQRRQLKPNLTQRVPSSSARPHPHGPNHSTRHLGGHPTSPSPPPSAATPLGSRAVSPTVCAEGQSHFLLFDYSLGLSGFSRYGVYTDSATNKLAKNPNPRFRFLPFHSPNKTHQLFVLKPVMCKVSSKRGIVWFLGTAVWVARPRPPPLNTISSRRRKRIMHALRVSGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTA3</accession>
    <name>A0AAV6TTA3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001118">
        <property type="protein sequence ID" value="KAG8174911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTA3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="242" mass="28167" checksum="7ABA86E5271E5239" modified="2024-11-27" version="1">MDTQMPPADNPLDEIRRNDLEYEALMTHGSLWVQCRLCPFPSNRQVKVWHLPEHLAERHGMDTSNSCAFCCGQFRNDDVENRLSWVRHRHQCYYHLTTSHGFHEDGRLTMDISDEMHATTFWRNSAWCASPLSNDFIPPLDIGEMNRGAAASDIPRSGEESLGEQRNDTDSTVLKSKLYYLCRMNERRRRGLYAKNHHVARVEEQLVRANEHIIKQNEIIAELERKGNLLLDRLLECELPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTH2</accession>
    <name>A0AAV6TTH2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gag-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001157">
        <property type="protein sequence ID" value="KAG8174736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTH2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33164" checksum="D195AD09BAEF0F42" modified="2024-11-27" version="1">MSSEMGEIKEAIKNSLDNLKIDLTNHSMPSTSASPTYADIIGRENNNTTTMFVDLPTDGEGGKDFKGFKNKLESLLTNENVKCNGIFETKKGVKISAPSLTDAHKIRDYLSKTETFSNLKVNVITKELPKFIVKFTNVGEEEKFMEQLTLKNPILKDISLKPLFKITLNDQYHWILEVPSNAYRIFSNLGFVFLGLSKHKIMEFLSIKHCKKCALYGHTTKRCPYAEDRCLKCGELAHQGTCVLSCFTCKTKNKSNYGFNEICKTNHRIASINCPEYRKQERLARSRIDHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUR6</accession>
    <name>A0AAV6TUR6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xrn1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001048">
        <property type="protein sequence ID" value="KAG8175187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUR6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="401" mass="46718" checksum="88EFE45C025D1848" modified="2024-11-27" version="1">MGITNFCKLIDPLHDPPNKPAPFDSILFDVQPFIHAGIASALESEESKLLLEVCRVAWYKLHKQLLQFLPFATNDSLTLVLSFDGEGVPMKWPTQRERRAKKDDTMDLKTKYRMVLFGVNQIALQVQAYFLSKLRHFTFRKLRQLHVYVSGCNVPGEGEHKLFHLAEALKTCRNPIVVSDDQDVFVISLMRLERYDSIQIYRYGRYYQVTRLYREWLPYPSKHLQVCSFLFGNDFVPALIGISLVNGPDIHQSMMIDAADHPVYMMAQFIQNMIQKIRFQRVTHMDNLLVESFWITFLWLYDYYTQTMFPQKYLENPVHQAFDRNQLLTALSDPDISLPCYERAKKAYDCATTALTTTKQAEYAVFGHDDILDQLKSYWVPQSSEACDVLHLTKKSSPRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWY6</accession>
    <name>A0AAV6TWY6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000896">
        <property type="protein sequence ID" value="KAG8176314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWY6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8880" checksum="B252BF7C9605F89A" modified="2024-11-27" version="1">MSVTSRAMLSYLFLLFDGGNYLVYQFLLQVYVTFTNGRDCRVKWRCLAQNKVKLAAASSQLYATRLLHSTFWNASSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZZ3</accession>
    <name>A0AAV6TZZ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000758">
        <property type="protein sequence ID" value="KAG8177712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZZ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="7984" checksum="C6918D12015ECFAD" modified="2024-11-27" version="1">MTSVPEVAWEQIHMDHAGPVDGQLGIRSSSSWTLSQNGSRFFQFQALPVQLPLQCCETCLLVLVYLKAWYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2A0</accession>
    <name>A0AAV6U2A0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase 7</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin thioesterase 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-specific-processing protease 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_008339</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000758">
        <property type="protein sequence ID" value="KAG8177714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2A0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03772">
        <property type="entry name" value="MATH_HAUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000064">
        <property type="entry name" value="Putative ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="14">
        <location>
            <begin position="64"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="15">
        <location>
            <begin position="222"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8177714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1111" mass="128244" checksum="30182AC1CD6DAB34" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5K0</accession>
    <name>A0AAV6U5K0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_025984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000601">
        <property type="protein sequence ID" value="KAG8179817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5K0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043496189" description="Cuticle protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8179817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15058" checksum="7F7335B587D67091" modified="2024-11-27" version="1">MFKTLLLCSMAAVALAQYASPYGKPDEIKYPPQPYQFGYDSNDEYGNTAYRKESGDGNGKVQGSYGYKDAQGIERIVEYVADENGYRAQIKTNEPGTENKSPADIDLYANPILVNYVPQPQQYQTAAAQAYKPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5Z7</accession>
    <name>A0AAV6U5Z7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RCC1 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000628">
        <property type="protein sequence ID" value="KAG8179395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5Z7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052830">
        <property type="entry name" value="RCC1_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46849">
        <property type="entry name" value="RCC1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46849:SF1">
        <property type="entry name" value="RCC1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="182"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="234"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38748" checksum="FA2488E2EB2FFAD5" modified="2024-11-27" version="1">MFIYFGSNTFNQLNDVKVENTISLFPEIKCFSKLIASYHPTIDDVFIGWSYLLFKAGDKIYHTGFSESNKEPGLKHISDFDDIDINTLTCGLKRSFLLTKKGNCYSFSTKEFRLTSIELGEYTGNIKSIDTEDSITVALTTGGKVLALHNEEKLSFHLLPMPLPVKEVSSGKEHVLFLTNCGKVYSYGFGSKGQLGHGMIENVKEPAVIEALEGIEIKSISCGGWHSAAISTEGDLYMWGWNESGQLGLPCNQLRADNSPIEKEFETVCCLPRVIDLEGEIPRIVRCGSRHTAVITENNQLWTWGWNGYGQLGHKKSLLSDKPEKVDLPKDLVPSSLKCKFWSTLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6U3</accession>
    <name>A0AAV6U6U3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pectinesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000609">
        <property type="protein sequence ID" value="KAG8179661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6U3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18168" checksum="06D2279A81A483BC" modified="2024-11-27" version="1">MSLQLRNTHKPINKYCNQRFQRIRVVPTYVVGIHGRIFSSTLAFNRHHQKHEDLSGQMTSYTTCIRLRLHAGESRYPQAKTNKYCNCDMIFDTAVLLANCDMIFDTAVLLANCDMIFDTAVLLANCDMIFDTAVLLANCDKEPVHNTSSLAIGPFDFDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U769</accession>
    <name>A0AAV6U769_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000607">
        <property type="protein sequence ID" value="KAG8179693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U769"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10034" checksum="5F512EABB9862BCE" modified="2024-11-27" version="1">MITTIPGPTEEETQKEPPYLRSRSAFAPVSLISVNAFSGMYGADRLCPLSTELVCRPVVDGSVVSWLWCSTTTTICMAGNRGATPDGRYCEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7N8</accession>
    <name>A0AAV6U7N8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTP-binding protein GEM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_015410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000595">
        <property type="protein sequence ID" value="KAG8179961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7N8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF6">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8179961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="42687" checksum="EF66A557ACF4533F" modified="2024-11-27" version="1">MSQRAPSRTRVSRSPSKSRSRSSEKILDGSTDKLAIPPFRLVTKSPSPCSRRRASAVHFTQSSPAGATKTSHTRSRSLRAKRHSAVLPHSSSGTQLAQHSLSVPTGDLGDFHLVRNFSVTSKGVVNRGDSFRCKSRSASLCSTPTTPTRGSDSASAFPEFESTASTSSSPVPTAASEVAKDVPKYTVWLMGSNGVGKSAIRNQFMTSEYICQYDTWKDETQTKSVMVSLDGEEAELDIVEYATIDDKSRPKDPLPDAFLVVYSVTNRRSYLQARQILSKLETSFGTRAAILVGNKTDLARLRTVPTVEGRSLAKERGCKFVETSVAINHQLDELLVGVITQIRIKARIAEKRTKKSGNQQRNCKATCIIKRLWRRTCMASKSCDNLHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7R9</accession>
    <name>A0AAV6U7R9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_017799</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000609">
        <property type="protein sequence ID" value="KAG8179660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7R9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038001">
        <property type="entry name" value="Caspase_ICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="10">
        <location>
            <begin position="105"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="9">
        <location>
            <begin position="268"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038001-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8179660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="361" mass="41859" checksum="A31E400B8AD1C961" modified="2024-11-27" version="1">MDRKCRHIITKFKHRLKEKVDLENIKLEVERRKLFTKVMLEDVYDSSNKDSEDLFYDLLCTRGPYAFFKFINILSEKGYNEERHMLQTEYSTDYAPHVYKMSSKPVGLCLIIINREFVTLKTRVESHIDKAALESLFETLGYDVTVKEGFEKKGLTAKEITYCLQEFSENSRLEKVDSFVVYILTHGNFINNRDALYGIDENIVFLDDIYEMFNHQNCSNMVGKPKWFIFQACRGGHEDVGYFGSGTNQSVDASDVTVSFPEIDSKPPLAHYPSLTDTIVVHSTMPFQVSIKDDHKGSWLCQDLVEVFSIDYLRHDLETMLKSVCKRMQERTSKNLYKQTIHVELFGVSGIVRFGQSKNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U996</accession>
    <name>A0AAV6U996_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine nucleotide-binding protein subunit beta-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_020137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000541">
        <property type="protein sequence ID" value="KAG8180907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U996"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="79"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8180907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40412" checksum="C89DDA5D517F55B4" modified="2024-11-27" version="1">MKDDAAPSLSTVTKANIVLGKLLAAKSESKDENQLKEELDGIIDKIKKAQAEAADKTIADICGDMSDCPKVPFRTKKILKGHLSKVTAIHYCGDNRNLVSGSLDGKLIIWDTWTGNKVQIIPLQSSWVMTVSYSPSGNYVACGGMDNMCTVYDVNSRDGSGTAKIRRELMGFEGFLSCCRFLDDNKLITGSADMKIILWDLEKGVKEYECDGHAGDVMSMSLHPDKSAFVTGSVDRTIKLWDTRDGDCKQTFWGHESDVNSVCFHSSGFYFGTGSDDKTARLFDIRADQQIGLYQTPSNKSGFTSCGLSTSGRVILCGSDDSAVHSWDTLKAKHNGCLTGHENRVTSLSMPDNGMAMVTGSWDSSVRVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9C5</accession>
    <name>A0AAV6U9C5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000559">
        <property type="protein sequence ID" value="KAG8180591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9C5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="135" mass="15340" checksum="19AA8256B232F5CA" modified="2024-11-27" version="1">MIWYGNVEGCGTAIWRSKVAGCGGAMLRNIPHSFTELELSLSLNSWNNSKQRKDAKFERRCLELTNAIKEARAEEIQVRVDARAVEQKTADAMAAREVKLSDSLAGFSTDFNERILPILERVEASQRGLRWRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9V5</accession>
    <name>A0AAV6U9V5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_000784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000533">
        <property type="protein sequence ID" value="KAG8181132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9V5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="6">
        <location>
            <begin position="297"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8181132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="694" mass="77891" checksum="8B69F17DA05A1D02" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAV4</accession>
    <name>A0AAV6UAV4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000531">
        <property type="protein sequence ID" value="KAG8181150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAV4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="134" mass="15106" checksum="07978ED457863550" modified="2024-11-27" version="1">MAKILKNLVFGQKKNPPAPPQPDYQGEGIPKGPFADHDYENIPRFTGEKSRVQFQEKKKPELVVFENYSEPADLLRDDSSSFQVDEDCDPVYMSPVDDASNNHEDVYCVPYEDDEARPPPLPSPCMAPGMAFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF58</accession>
    <name>A0AAV6UF58_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_010751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000464">
        <property type="protein sequence ID" value="KAG8182388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF58"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF6">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8182388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="196" mass="21858" checksum="A7FE75F2A3912C71" modified="2024-11-27" version="1">MCHQQIKIEEDAEKNVSVLLDGDEHDISFIDPPTMPDTPNDDVMDGDAFVVVYSITERSSFEKAVDILFKLREKGCTMNKTVILVGNKSDLVRTRDIAADEAKSVACSYECKFIETSAAINHQVDELLVGIVTQIRLKTQRQIEMSNFTTDTTRNNRQLNKRMSFSGSGRKAKGILSKLMGKGKIKSQSCGNLHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFH6</accession>
    <name>A0AAV6UFH6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000445">
        <property type="protein sequence ID" value="KAG8182845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFH6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026120">
        <property type="entry name" value="TMEM11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14972">
        <property type="entry name" value="Mito_morph_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="189" mass="20930" checksum="336B030796C7DA60" modified="2024-11-27" version="1">MGNQPAVLSVNKEDKTIIQQQLSEATADEKSVIVIKNPYFKTEVAIGMVLAEHSQHAALVAAVGSILCTQSASETFVWLGKPLAVGSVITNIGYYGLWKRCPLSKYRISTRPTIYKMLTRQEQPNTVLVREGAPQSFRLIHILTSAAALVLAFYEDVYDLSDRLHDLSDRLRDFLFSPTEAKDGDGSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UG12</accession>
    <name>A0AAV6UG12_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA 4-demethylwyosine synthase (AdoMet-dependent)</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_010894</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000433">
        <property type="protein sequence ID" value="KAG8183070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UG12"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="16">
        <location>
            <begin position="49"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="340"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8183070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="671" mass="75975" checksum="ECF4012F2171AAD0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGM6</accession>
    <name>A0AAV6UGM6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_018659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000448">
        <property type="protein sequence ID" value="KAG8182786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGM6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034743">
        <property type="entry name" value="RH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09744">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51776">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RH1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="209"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8182786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="325" mass="38112" checksum="33979491799C958A" modified="2024-11-27" version="1">MSNSLQVKDVYDYAYDIAQEFDKIVDTVDIEQATPLINKVINVLELLEDHVKQLEQLEQENVNLRAKYIQWTCEKNSIEQEKSSLKQAFEELEESWSQESIMLKSLIERLKKENNILMQSISAKKDIPKETDDCINAVVSDQTNLIAKLQLHLKQKGTQLENNHATIELLNSKIEDLLKLNKSLHLRYREVKDLLKVSYSEKYEYKFKQDLQEQKISDLETKYEALKKSLAEKNEDTPKVVYRSFEEKVGDDVKMNVNCLIEEQNNLRLTISKLQNELVLTKRQCEEYKRKFNKVSEKLSQSSSQENGYIQQIFRLFLGAIHINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGY5</accession>
    <name>A0AAV6UGY5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000444">
        <property type="protein sequence ID" value="KAG8182855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGY5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="184" mass="20957" checksum="012EC27A3598FF18" modified="2024-11-27" version="1">MVSSNQAANGTRNSMKDNSLGFKSLVSDHCIYKLNTPSKEVIICVFVDDLLCFTDSEDSYKFIGDKLASSFRMKDLGRLHYCLGIEFSQDEGKLKMSQAKYIDDLLRKFNMEDAKTVTTPMDPSQKLTTEMCPKNDAERSEMEDIPYRPLMYLSVATRPDITHSVNFLCQFNNNPGKLHWQAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI60</accession>
    <name>A0AAV6UI60_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0489 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000417">
        <property type="protein sequence ID" value="KAG8183438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UI60"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024131">
        <property type="entry name" value="UPF0489"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13225">
        <property type="entry name" value="MISEXPRESSION SUPPRESSOR OF RAS 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13225:SF3">
        <property type="entry name" value="UPF0489 PROTEIN C5ORF22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="137" mass="15354" checksum="AD70CEF05947449C" modified="2024-11-27" version="1">MTTNRRDSGTKGLKLQYPEVQPLLSTFPDSRPPDPDLLNDAGCTCDDCDLPHHVSGKDEVRHLVDATRNFLRRLPRPAVITVARSSRDDYCPPEDVDFIQELVLAMLEQVYGIIEVHKDYSEEESGAEEDIQGPSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI93</accession>
    <name>A0AAV6UI93_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_017103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000436">
        <property type="protein sequence ID" value="KAG8183016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UI93"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052110">
        <property type="entry name" value="MCFD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104">
        <property type="entry name" value="MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8183016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="189" mass="22516" checksum="4DF3EB0B7FF59090" modified="2024-11-27" version="1">MRHLSCIARSSTELFNWKVFNSYLAMIYILSCALWLVFIAEAHIRHEGHTHYQPKEDGSKNLLKDKAYVRDYEHVKEDLQDLYNKDFAAELSEMELESYYFQLHDLNHDQKLDGLELLAAMNHVLNREDEISQKDLLENPQVKESLQNWWNTKFKEDSEYIDEMLKEEDLDQDGYLSYAEFISARQKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIH1</accession>
    <name>A0AAV6UIH1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_006859</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000396">
        <property type="protein sequence ID" value="KAG8183932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIH1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054473">
        <property type="entry name" value="KIF2A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22923">
        <property type="entry name" value="KIF2A-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="246"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="336"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8183932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="709" mass="79690" checksum="4DAB7A0288EB4091" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIM9</accession>
    <name>A0AAV6UIM9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000415">
        <property type="protein sequence ID" value="KAG8183476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIM9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="176" mass="20112" checksum="6A03AB448659D3E3" modified="2024-11-27" version="1">MVFLWRIFRKLCEEVSNKEESTYSLTGRRVVELGYFLDALKDFLHHDDKGRLGCTFHNVQVCGEIRKGLNSGLKLKCAMCNFEKTVWTNDTKSEIMDVNKAATIGIMEIGFSNLQDLTAILNIPPMSNTLFQKEQNIIADAWAKTAAREMELAIEEEKRLAKERGDVEWMLMGMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJZ1</accession>
    <name>A0AAV6UJZ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_019339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000363">
        <property type="protein sequence ID" value="KAG8184740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJZ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
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        </source>
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            <dbReference type="EMBL" id="KAG8184740.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="180" mass="21093" checksum="A356FA8B43182FFF" modified="2024-11-27" version="1">MGRVYVRKSGARKYKQWSEEQMDQALYEIREKKISLRQASKRYCISRTTLSTKLKDIPVRKPGAPPVFSPKEEQGIASHLKTLVSNGFSLNRLGLRLFIYVYLSRNNRNVPRFYDNMPGKEWADLFLKRNKEELSELIIRRTGRFQKVLDISSIHEYFDNLNYELLPSLPNESDMGTLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
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        <dbReference type="NCBI Taxonomy" id="931172"/>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
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            <dbReference type="PubMed" id="34949821"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">W744_W776</strain>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKX1</accession>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
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            <dbReference type="PubMed" id="34949821"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="17">W744_W776</strain>
        </source>
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            <text>K(+)(in) = K(+)(out)</text>
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            <dbReference type="ChEBI" id="CHEBI:29103"/>
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="42"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="15">
        <location>
            <begin position="572"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8184924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="72286" checksum="BFBF041D58BDD76A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMG2</accession>
    <name>A0AAV6UMG2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000357">
        <property type="protein sequence ID" value="KAG8184873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMG2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="444"/>
        </location>
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            <begin position="472"/>
            <end position="636"/>
        </location>
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            <end position="741"/>
        </location>
    </feature>
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        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
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        <location>
            <begin position="509"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="KAG8184873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1088" mass="121566" checksum="FAE9D716283EABB2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMS2</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
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            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000349">
        <property type="protein sequence ID" value="KAG8185034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMS2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="96" mass="10748" checksum="A6CAB088198191C3" modified="2024-11-27" version="1">MCSHISRRTKRVDIIRRNSRPFADPRRLGQSPTAKDGAQGERGGILFICAQGCTSPLSACDKNSRPSKTNIVQRGRDKNTFRRSLAGRFLWRAVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMT1</accession>
    <name>A0AAV6UMT1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_022363</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000335">
        <property type="protein sequence ID" value="KAG8185432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060429">
        <property type="term" value="P:epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000024">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043775820" description="Cadherin domain-containing protein" evidence="14">
        <location>
            <begin position="27"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="43"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="144"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="255"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="370"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="480"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="592"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="692"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="796"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="908"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1018"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1123"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1223"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1331"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1429"/>
            <end position="1533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8185432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1589" mass="176551" checksum="F3E30A1FFE4A030E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UN63</accession>
    <name>A0AAV6UN63_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000344">
        <property type="protein sequence ID" value="KAG8185169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UN63"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11439" checksum="36504DD6BF414CE8" modified="2024-11-27" version="1">MGRKRKSTAKKGEEMRAKRQAAVVSSAVVQQEDSTEKILNRITELNTHVPISSTVPISSNEYVLMSMNSLQTLIQQCKCSICCDGSDLLYGPPWRDVFGFGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNP1</accession>
    <name>A0AAV6UNP1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000340">
        <property type="protein sequence ID" value="KAG8185323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNP1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="140" mass="16129" checksum="07F6DBA2C6E099D5" modified="2024-11-27" version="1">MIRLHPIYADKSSLYPAACSKAKQKLMMKTTWREWNEVPHIKFQKRKQKFNGNFHPLFLIPDFLPKRSIRTFHPLHPPPQFGGSKPPKGKNTRLPLGLIILFPLEIEGRLHSRARDNGREDVVPSLMGLEFVLVDLVVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPW0</accession>
    <name>A0AAV6UPW0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATA zinc finger domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_008729</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000309">
        <property type="protein sequence ID" value="KAG8186199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPW0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039050">
        <property type="entry name" value="GATAD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13340">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13340:SF2">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8186199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="248" mass="27367" checksum="A1E1483DCDA56D07" modified="2024-11-27" version="1">MPLGLKPKCTLCKTTTSSMWRKTEDDEVICNSCSVRPAPSTNPTTSKASSNGSTNGSTSSTSCVSCPFTLRKSTRAKSTKFKQTAAAKNANPKGKSRRSIFKKSCIKAPTSVATPVTSQAMFYKGIYYQVGDIVSVVDSERDVYYCQIRGLLQDQYCEKSAVITWLLPTASSPKNRFDPATYIIGPEEEVPRKMECFQFVCHAPSEYYQAKSSPYPVIPVKPESGFIWTRVGPRFVPLPSQEEVFGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQR6</accession>
    <name>A0AAV6UQR6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000299">
        <property type="protein sequence ID" value="KAG8186499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQR6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="104" mass="11700" checksum="E45BDBE8C24D7CB4" modified="2024-11-27" version="1">MEFFILPCSNGFSPPYFLSTFPRASAKPECARALSSLGSDSELTETIAPWKEAQTSLFPGFFFRGCISYNPPLHLQKELLHAVRVLFLLVSVYLKLILNLVVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UR46</accession>
    <name>A0AAV6UR46_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MYM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_000744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000325">
        <property type="protein sequence ID" value="KAG8185761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UR46"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052787">
        <property type="entry name" value="MAVS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010507">
        <property type="entry name" value="Znf_MYM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446">
        <property type="entry name" value="DUF3504 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446:SF12">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06467">
        <property type="entry name" value="zf-FCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MYM-type" evidence="2">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8185761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="918" mass="102707" checksum="E3A19C0C7E412793" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UR74</accession>
    <name>A0AAV6UR74_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000296">
        <property type="protein sequence ID" value="KAG8186604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UR74"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7606" checksum="D66E5EF257371E31" modified="2024-11-27" version="1">MSYLSCYCLSYGFCISGCRILQNMAQNIINSSLWISFLNSMASRAVITTGKEEDILKNPWDALDYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URQ7</accession>
    <name>A0AAV6URQ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_023773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000286">
        <property type="protein sequence ID" value="KAG8186884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URQ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="68"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8186884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="623" mass="69832" checksum="CA9C5E30E79DADF4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6US32</accession>
    <name>A0AAV6US32_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Suppressor of fused homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_003188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUFU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000312">
        <property type="protein sequence ID" value="KAG8186106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6US32"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.230">
        <property type="entry name" value="Sufu, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020941">
        <property type="entry name" value="SUFU-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024314">
        <property type="entry name" value="SUFU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038489">
        <property type="entry name" value="SUFU_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037181">
        <property type="entry name" value="SUFU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007768">
        <property type="entry name" value="Suppressor_of_fused"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016591">
        <property type="entry name" value="Suppressor_of_fused_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10928">
        <property type="entry name" value="SUPPRESSOR OF FUSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10928:SF2">
        <property type="entry name" value="SUPPRESSOR OF FUSED HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05076">
        <property type="entry name" value="SUFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12470">
        <property type="entry name" value="SUFU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011844">
        <property type="entry name" value="Suppressor_of_fused_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103359">
        <property type="entry name" value="Suppressor of Fused, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor of fused-like" evidence="3">
        <location>
            <begin position="56"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Suppressor of fused C-terminal" evidence="4">
        <location>
            <begin position="245"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR011844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8186106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="469" mass="50807" checksum="7D0B6AC8129FE98D" modified="2024-11-27" version="1">MEPQIFRPPMYRTPPLRLPPVIPLGLQALYGACRAIYPDQPNPLQVAALVKYWLGGPDPLDYISMYSNPGNPEAGIPPHWHYVSFGLSDLHGDGRVHGRDGLSSGFGFELTFRLARGPGDGPVPPTWPAAILQALAKYVFQTENTLCAGDHVSWHCPLDNSESRVQHMLMCEDPQLGTVATPFGPVAFVQIVGALQEELHAAQGWNGPGVVDLLRGAPGAGGSWLVTDMRRRESLFQLSPGARAQVDAGIAQDGSNLSGVSARCTWRELARGQDEEELERGFAQISVREEEQIKAALAEGLRGSSSKPPFAPRVRSPLDDRPEEEQERPSTALAVQEEEEEVVEPPAGGGAETRHLERVQVTLDLEAGTLLVLALRGRLLHGRHFTFKGVVGDAAVTLVPPGVAGAFVEEGRPLGTRGPWLQVLLQEGDVARMLADLQVLAGGCEALSLPKTFHWCGSRLLVTLMHEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USU2</accession>
    <name>A0AAV6USU2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_009532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FRAS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000272">
        <property type="protein sequence ID" value="KAG8187462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF1">
        <property type="entry name" value="EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043395035" description="VWFC domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="3730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="3636"/>
            <end position="3660"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="1262"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="1502"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="1625"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="1869"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="1990"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="2102"/>
            <end position="2191"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="2226"/>
            <end position="2323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8187462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="3730" mass="417151" checksum="26CF11AE9795A2ED" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTN4</accession>
    <name>A0AAV6UTN4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000263">
        <property type="protein sequence ID" value="KAG8187692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTN4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="95" mass="11238" checksum="9E96462ACD7B5D41" modified="2024-11-27" version="1">MVERGKQIITMVERGKLIITMVERGKQIITMAERGKLIITMVERGKLIITMVESERQTTDCFDMEDINLKKQRWLVKKNWQHAEKTHNTQKLNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU39</accession>
    <name>A0AAV6UU39_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000273">
        <property type="protein sequence ID" value="KAG8187353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU39"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="117" mass="13174" checksum="4796C4CB44918237" modified="2024-11-27" version="1">MCGLLEIHQVSLSWNSKIKGMQKKQYLNLMERAYVVKESGWKCRMGKLAETGAEVETGVLVLLGVQDTQEAEAAVQDTMEGIGADRIQETDDKQVCQRVKKFMTFEGVQPIVYISLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU89</accession>
    <name>A0AAV6UU89_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_009928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000251">
        <property type="protein sequence ID" value="KAG8188055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU89"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="768"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8188055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="968" mass="110284" checksum="9DC59689F79D8FB8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UX91</accession>
    <name>A0AAV6UX91_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone RNA hairpin-binding protein RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_014983</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000227">
        <property type="protein sequence ID" value="KAG8188931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UX91"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071204">
        <property type="term" value="C:histone pre-mRNA 3'end processing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071207">
        <property type="term" value="F:histone pre-mRNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1120:FF:000001">
        <property type="entry name" value="Histone RNA hairpin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1120">
        <property type="entry name" value="Histone RNA hairpin-binding protein RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026502">
        <property type="entry name" value="SLBP1/SLBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029344">
        <property type="entry name" value="SLBP_RNA_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038294">
        <property type="entry name" value="SLBP_RNA_bind_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408:SF0">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15247">
        <property type="entry name" value="SLBP_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Histone RNA hairpin-binding protein RNA-binding" evidence="4">
        <location>
            <begin position="170"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8188931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="260" mass="28692" checksum="2258F05C9F12A2BD" modified="2024-11-27" version="1">MNAKPRLSKSRPSADESPAKERRSGLRSGKLSWAEMCDAADGGLDVNSPFKALAVNTPDKQGKADKGTKSQEVKASNGATANGKAAKSPKSQEVKEKVSHVGGSPPRTRGSTKKRERQDGALLTSPSLEGVKRRLGWSRARNVPDDVSTEESSSMCSSEDLEGGARYEADPEVLRRRQKQIDYGKNTRGYRLYVAAVPKASRTAEHIFTPKKHVKYSRRSWDAQIKAWRKRLHDWDPRSEDEEEDQQADVDLSDMAGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXW1</accession>
    <name>A0AAV6UXW1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXW1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF235">
        <property type="entry name" value="CUTICULAR PROTEIN 73D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043451054" evidence="2">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8188484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="175" mass="18859" checksum="F105D149D4A29622" modified="2024-11-27" version="1">MRSFMILVSAVVLMVEYSSAKGYDTGSGDIVPGYDNGMDSNSRYGGSQIGKLGNGAYGNVKPIPYNAEYNTADEQGNHQFRQEQGDGNGNVRGSYGYRDIQGLYRTVQYVAGRDGFKASVLTNEPGTDGKENPAGTVMNVQKTPAGIVDKYTRRNSGFVGIGGHRSAESSTRQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UY91</accession>
    <name>A0AAV6UY91_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000220">
        <property type="protein sequence ID" value="KAG8189154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UY91"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8861" checksum="B904632B91E058EC" modified="2024-11-27" version="1">MKETRSLFGNGKIEVEIRDRGKLRPPSLRSNSHTSRIGQEKPSPSTGCYGRKIVRTSEEKCSIGTKEEDLKMTPQQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYR4</accession>
    <name>A0AAV6UYR4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000211">
        <property type="protein sequence ID" value="KAG8189582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYR4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10869" checksum="E7ABD5791F303FF0" modified="2024-11-27" version="1">MSSTPVNGQPPYLRLKASARPRDKTNTRMNERSNRRRQVMEKKWEDRAKRPKMKLRLPSRSLPMEDAGGTFRCSLDAWEDAWRAGIPKYRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0D7</accession>
    <name>A0AAV6V0D7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_011951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000191">
        <property type="protein sequence ID" value="KAG8190230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0D7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8190230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="7530" checksum="81544C8543DD9342" modified="2024-11-27" version="1">MDFSSVALVTAAVIAASVIGVLSIFLIAFFCLMEAEEVPHEPQETDELTRDMSPIPGCSTSESTHLVCTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1L3</accession>
    <name>A0AAV6V1L3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000198">
        <property type="protein sequence ID" value="KAG8189983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1L3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="176" mass="20135" checksum="DA5489BFAB29E2AF" modified="2024-11-27" version="1">MKFLSFITSKHKATPITVYFNIRTFKQSCPVYIRALLTTDRNTSKISSPKKLRGQKQPITRLNLSHNQEIPQAHFMQTPQQETSNIIMLQDLDTLVDHLANQSVNVCEKVFLVQENYGQNSVEEVFANTPVILATDTTDDKVTGSRTDNAIEGLVREKKRSNDLKEKLLEESRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1N7</accession>
    <name>A0AAV6V1N7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP-dependent glucokinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_009074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000199">
        <property type="protein sequence ID" value="KAG8189932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1N7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043843">
        <property type="term" value="F:ADP-specific glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007666">
        <property type="entry name" value="ADP_PFK/GK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208:SF1">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04587">
        <property type="entry name" value="ADP_PFK_GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51255">
        <property type="entry name" value="ADPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8189932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="56448" checksum="FB5EC139454618CF" modified="2024-11-27" version="1">MSGRNKKRKERGKDRRLLGFKYNTRMMNTARKLATVFLISFAVVIVAYAYNKYKLQNTTNKLEETLSSLLRIENSARVSPGIKIALGFGSCQDIIVQSNQVILDRPPEIPEHFYSIGTKEELLKVFAYFYRHGAAAERFISNSTLFQELVHLAEKASSAKYTIGGNAPIMANRFVKEGCSVLLGAQMSRSLQSKFPDEIQISGPFVERDDIHLLLEYPTGQRWGNFVPPRANRFIVHNDHQNPELSSLNSFVKQIEEYNPNLLVIGGLQMMDNFPMSESKQREHLVKVQDLMQKQSDNVRIHFEMASFSDENLLRNLVENIIPYADSLGMNEQELPNLFHMMKYGNITLVAESSPRIAVILDQMRDVFEFLQGTQATLGRRKLTRLHLHTLAFQAFMVDRNSKWKNTKAAAAKSALTAYRHTCGSDEIESTKARLVMDEAFTVSLRGELKRVPFDSQDPVSCWAEDNIEICIAPVLVCTQVVQTGGGGDNISSAGLVLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1Q8</accession>
    <name>A0AAV6V1Q8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidylcholine transfer protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">START domain-containing protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">StAR-related lipid transfer protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_012920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Interacts with ACOT13/THEM2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000205">
        <property type="protein sequence ID" value="KAG8189744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1Q8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000017">
        <property type="entry name" value="Phosphatidylcholine transfer protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF8">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="START" evidence="12">
        <location>
            <begin position="211"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8189744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="431" mass="50899" checksum="684B498A5010CFF1" modified="2024-11-27" version="1">MAKLKVNLQGCCVYNNLTRNFRNNYRSYSANELSIDWKRRFSLSARSDASERRGYTLKSILEFDTRKKLWDDFKSHCNEKLVILGEILTNQCNFIASQRVRRMSQMWNLYNQLYSEKTVKTIVSQWSRNLRSKTRPFSLMLGTALFSWESEKITDEEIQKIRKVDESLLEEMHIFRNRNLDCACELEGYRSSEDHPTKPISGQGLVNKLLEDGWEAVIKKECIQVWRKAFPNSYLYEYKIMGTFYDVPARTFFAVQTDIEYRKKWDKLVIKLDVIDKENVDGGCEVMHWVMHYPYPMYSREYVYIRRAVISPQTNTMVLVSRAIVHPSCPVNNKYVRVYDYSSRMVIRPHRTYDENGFDYVLTYFDDPQAAFPAPAYNWMARSGVPDFVEKLHEAAKELHSQQLKNKSILPPIMPSKDTCTTTNNFDYVYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V235</accession>
    <name>A0AAV6V235_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IRF tryptophan pentad repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_022030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000185">
        <property type="protein sequence ID" value="KAG8190387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V235"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001346">
        <property type="entry name" value="Interferon_reg_fact_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949:SF53">
        <property type="entry name" value="IRF TRYPTOPHAN PENTAD REPEAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00605">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00348">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51507">
        <property type="entry name" value="IRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRF tryptophan pentad repeat" evidence="2">
        <location>
            <begin position="44"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8190387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="357" mass="41421" checksum="36B360F1BCB5E3F5" modified="2024-11-27" version="1">MSSSYLPPQRSSFCSVIGRYSICSGLKKQSFTLTVERVMTRIGRRLIEDFLLPALNDQRYGELLKWVDRDKRHFSIRWSHKNAAKWTLADTAVFQDWDKLKGHYRPEIKGYYMQAKQRFRAALYKLSSVRKLPCEDKHVKKYQLMMDGDKRREIMQIRPKIKKEENQRSIPTSVIRKNTSYIEKLPVKAVYKMEDLDLEDDLSPIPPSPTSSERSSSSDDQEEMKTVFFQYMLAQKNQRQNGYTSDDNTGNQYESCTKGDVLRESNGVSLRIPHVPIQQVPVYSGSVKSFYDSSQKRYESPRVLLVKTYNDLSEDEPPTAVKEEPIDHYETECPISNPPDIALNLSIKSDDSETLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5N1</accession>
    <name>A0AAV6V5N1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000149">
        <property type="protein sequence ID" value="KAG8191937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5N1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7686" checksum="F1676830F30684FD" modified="2024-11-27" version="1">MLADDSGGNNLLRLLDEEQRSSSTLHRNLSRCEAKLKRKNLDEPAFKALRIVYETSHDERSEIRNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V827</accession>
    <name>A0AAV6V827_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_014619</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000134">
        <property type="protein sequence ID" value="KAG8192839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V827"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF10">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="71"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="519"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="579"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="624"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8192839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="673" mass="75696" checksum="E6826B945880F97C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V936</accession>
    <name>A0AAV6V936_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_017989</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000139">
        <property type="protein sequence ID" value="KAG8192459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24172">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24172:SF4">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="8" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="9" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="601"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="796"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="421"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="841"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1201"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="857"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="896"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <begin position="923"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="952"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="971"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1016"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1028"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
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            <end position="1096"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1103"/>
            <end position="1122"/>
        </location>
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        <location>
            <begin position="1134"/>
            <end position="1144"/>
        </location>
    </feature>
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        <location>
            <begin position="1213"/>
            <end position="1226"/>
        </location>
    </feature>
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        <location>
            <begin position="1234"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1272"/>
            <end position="1283"/>
        </location>
    </feature>
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        <location>
            <begin position="1317"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1337"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1385"/>
            <end position="1399"/>
        </location>
    </feature>
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            <begin position="1413"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1424"/>
            <end position="1435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8192459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1435" mass="160905" checksum="AD5B03667519AE51" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VA00</accession>
    <name>A0AAV6VA00_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000120">
        <property type="protein sequence ID" value="KAG8193484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VA00"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="2">
        <location>
            <begin position="79"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="150" mass="16591" checksum="79F5BBEB726E8D79" modified="2024-11-27" version="1">MFIRGKTEVDFLGFRVDKEGIHPSRSKVEAIHAAPIPADKQQLQAFLGLINFYHSFLKGKASFAEPLHRLLDSDAKWVWLDSHTGVFNKLKNLISSDSVLVPFDETLSILLTCDASPYGVGAILNHQLPDGREAPIAFSSRTLTSTELKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VB73</accession>
    <name>A0AAV6VB73_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000113">
        <property type="protein sequence ID" value="KAG8193947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VB73"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="41530" checksum="27AE1F7575290999" modified="2024-11-27" version="1">MEEMLPIKEKNYSRGSKEIITEKLCVLLDRCNVSDRDAVRIIAAAAEALDANLQELSLSRTTVRARRQKFREQRANIIKNRFQNSDFSNAVLHWDGKLVSHSSNKDAERLAVLISCGDEEQLIGVPEIENSKGLSQAKAVFSEINKWGAAEKIEAMCFDTTAANTGCWKGTCTLLEQYFEKHLLYLACRHHILELLLKAVFESKFGATTGPQPEMFKKFQMKWPVIDKKQYKFGIEDLLVKIHFSDLEEISGFLLNQLEQKHPRENYKEFLQFKLSTDFLKSDPSMWEQDLSFLKGKNIVRNLRVVNDTAERGVKLIQDYSNTIRKDEKQKQYLLQIISECRKIYPDVRKSSLEKPLPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VC35</accession>
    <name>A0AAV6VC35_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Agrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_005564</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000127">
        <property type="protein sequence ID" value="KAG8193216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VC35"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000209">
        <property type="entry name" value="Laminin subunit alpha 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000057">
        <property type="entry name" value="protocadherin Fat 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000134">
        <property type="entry name" value="Transmembrane agrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000024">
        <property type="entry name" value="Transmembrane agrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003884">
        <property type="entry name" value="FacI_MAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF83">
        <property type="entry name" value="AGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00057">
        <property type="entry name" value="FIMAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Kazal-like" evidence="17">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="17">
        <location>
            <begin position="58"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="17">
        <location>
            <begin position="142"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="280"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="333"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="17">
        <location>
            <begin position="413"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="14">
        <location>
            <begin position="533"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="711"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="750"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="14">
        <location>
            <begin position="797"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="979"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="14">
        <location>
            <begin position="1029"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1005"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8193216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1207" mass="130517" checksum="697BC8E123108F14" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VD55</accession>
    <name>A0AAV6VD55_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_011433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000113">
        <property type="protein sequence ID" value="KAG8193873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VD55"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="130"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="294" mass="32958" checksum="19C5CB6FB6EBAA08" modified="2024-11-27" version="1">MILDSKDVKDKYHIALALTIIDGCFSFVYCSFVCDCIMAKKTSNCTDIKYNDLRTEYKEDWRIVKSGVTRNASCKFNLQLDTIVAHHNNSQYQITHPTSSAIAKIGGSSETVNGPLSNDLLQLYRDGILSDATINTDGKSFSAHRSILAARSPVFRAMFEKDEMNEGRSGVVDIDDVDSETVDRMLVFLYGDSLQGLEWGEAASLYYAADKYAVQPLKQKCAHILKAGLTVDNVCDALVLADTHSDEQLMKNVADFIYDHQEVVSSPKFEQLEDIKPRLTSKVANELFLKRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDV9</accession>
    <name>A0AAV6VDV9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_029175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRELD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000097">
        <property type="protein sequence ID" value="KAG8194884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDV9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044023381" description="EGF-like domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8194884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="377" mass="42041" checksum="7D0A00014DE52965" modified="2024-11-27" version="1">MKLLCSLCFSFIFLVVVAEETTVNESKVSSKLKKEGLPPCQACRILTNSFKKGMERTSRGKFEGGDAQWEESRLGAYADSEIRLVEIQEKLCSDEEKGSEQCHNLAEEQESVLEDWWFKKKSSFPDIYYFLCIDKLQVCCPENHYGPDCKPCIGGLVNPCNGRGQCKGGGTRKGSGTCRCDTGYTGEFCDKCKVGYYNNTPNQDSWECTKCDKACKGHCREGGPKGCEVCADGYQYSTEFGCIDIDECIEHSPHPCKHGTFCVNAIGTHRCVECDKACEGCTGDGPDMCEKCAKGYVFQEPLCIENKTWQRSLHVEVARYATYLGLCIATCIIFRRSIYVASIIGVFVAIYIGLSEYTVGEWNNRNLIKSIKSLTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VE33</accession>
    <name>A0AAV6VE33_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA damage-inducible transcript 4-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_013675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDIT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000112">
        <property type="protein sequence ID" value="KAG8193981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VE33"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.40">
        <property type="entry name" value="RTP801-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012918">
        <property type="entry name" value="RTP801-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038281">
        <property type="entry name" value="RTP801-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12478">
        <property type="entry name" value="DNA-DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN DDIT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12478:SF16">
        <property type="entry name" value="PROTEIN CHARYBDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07809">
        <property type="entry name" value="RTP801_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8193981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24986" checksum="9E65DD25564DD5BE" modified="2024-11-27" version="1">MSWNYESSTATKSSSLPLNRVFDKFADIICQEWNDTMKVHANPPVIWSRPRYAQDCDIIEPKNNMNGVLYFDNEPSERVLACQSLVERLEQGLREAKLLHLQCGEVLLPHDLIWRIADQVLTASEFEPCGLRGCLIYIHIRDAKKLERRRVGVVKCDPNTVATFEIHLTLFQDNNSFFGLRHLLPDKLLQSLGKRSSLVVSSHFLLDKKKLYRSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VED3</accession>
    <name>A0AAV6VED3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 186</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_011001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000103">
        <property type="protein sequence ID" value="KAG8194387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VED3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099518">
        <property type="term" value="P:vesicle cytoskeletal trafficking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038830">
        <property type="entry name" value="CCDC186"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911">
        <property type="entry name" value="CTCL TUMOR ANTIGEN HD-CL-01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="343"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="596"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="708"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8194387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="86686" checksum="A24AB4DB07E228D5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFM4</accession>
    <name>A0AAV6VFM4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000103">
        <property type="protein sequence ID" value="KAG8194456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFM4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8991" checksum="A7C5F9C6484CDEAF" modified="2024-11-27" version="1">MWCLRPRSFNRFFSFYSSLLDWSHRVKGLRPCFEAKAAFLNIGLRPGIDPRQHAYMAASPAFLSPATTFFQQARHVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHL8</accession>
    <name>A0AAV6VHL8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">26S proteasome non-ATPase regulatory subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_002189</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000084">
        <property type="protein sequence ID" value="KAG8195563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHL8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="11" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8195563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25355" checksum="5B1EE0F434FF2526" modified="2024-11-27" version="1">MSELELCRFAYEGKFEKLKEKIEKDKDCISSKDGSGRVPLHWAASGSQKNIVNYLLQQGSPVDEPDDSNWTPLMIGSSVGCLDIVEVLIERGANVNAINQTGQTALHYAASKNREQIVRVLLSHHANINACDHMGSTPLHRASSKGNLKVLRIFLQEFSNQLNLSPCDCVGNTPLHLACEEERLEAAKMLIEAGANTDTLNKEKISAFDMAPKQLRAQLQKMADEATPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VI79</accession>
    <name>A0AAV6VI79_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 102A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_002986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000080">
        <property type="protein sequence ID" value="KAG8195725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VI79"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46292">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46292:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin tail" evidence="5">
        <location>
            <begin position="390"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="254"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="405"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8195725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="576" mass="66806" checksum="3AF692B568BA510C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VII4</accession>
    <name>A0AAV6VII4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000076">
        <property type="protein sequence ID" value="KAG8195943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VII4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="324" mass="37569" checksum="678C54A1A8E13B6D" modified="2024-11-27" version="1">MRTKGVLFACSPAEGVHKKVRKFRDCVPYVYPAGIKIDDIGLLCCLQNSCKQNLKIYKPKITESYVHSKKREESIVELDTSEISVLSTKKTSKLSSSKRQETKDLVQYHHRLAVERKDRLQYIMERYENDSRNDIDDEVDFNDFTLITKSGESKYFGCEDWNPDGYIFSKKNAQHMRKLVKSAQMNVKSTDIKKKMKCGKLPNLSKKNREQKSPEYVSIHELYKTSDINLSSKKVSSAKSTKKMHSSWQDVSHGSSDATSPFKKFDELTMNKNQNINIHKKRKYVSLHELYKTSDINLSSKKVSSAKSTKKMHSSWQDVFTWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJ03</accession>
    <name>A0AAV6VJ03_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_007867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJ03"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="436"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8196131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="484" mass="53680" checksum="49D930B2EC196A34" modified="2024-11-27" version="1">MSREDVFDKLETLVLDEERLVTCKILSREFQMHVNEARAYLADFLAVQKTKENVSLKATYFLAGLQEIDGIKSVKVLIASEESLEKAKNNLIEVTSCHIYSISKVRADEVVLYNTDLSYNHKGQESRDLLVIKHPNVEIKEPILRKSNQLKSDVKPPLKSQNIGALKNSSASIQTNGKSKTPSDAANNKAKETESEKPDKASTAAEPKKSNVEVQKPNTLASMWQKNEEKSKVAKTESSKTEGKGKTKSPQETKKSLPKNNIMSMFSKQAEKNAVNTVKKAPANDPMPEKKVEVVSNKPAEKVASTSKNPPKSNDKKRKLPEKKAKSSVKQSSDSDTEESKPAKKKHRRIAVFDDSDSNSDGEDIEAEDKAQRSLWLPEDPIEAESPVVAPTPDTDDGEDPIPPTPPVIQQKGRKKISKTVKKTFMDDDGFMVTTEEKEIVSESGSDEEPIPTKSSSKGSKEAVKSNNFSYRKQASLTNFFKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJC3</accession>
    <name>A0AAV6VJC3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJC3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7650" checksum="C396AAB97AC9471B" modified="2024-11-27" version="1">MDHRSILISFWSTPNRHCHGQPPKSLTMLKYTIRSCSLLPSDYRHLEDGMPSGREARIGTSISLPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKF6</accession>
    <name>A0AAV6VKF6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000062">
        <property type="protein sequence ID" value="KAG8196945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKF6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11847" checksum="D04E13B99554C968" modified="2024-11-27" version="1">MYQDHLRCSSSLEWRTGSYKATFLLCSFVLVANVHRSSPNVGHTKQRSCCVRSYCQRSSFFTQCWTYKAAFLLCSFVLVANVHRSSPNVEPTAARKQAHQEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKK1</accession>
    <name>A0AAV6VKK1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_023198</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000065">
        <property type="protein sequence ID" value="KAG8196686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKK1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000002">
        <property type="entry name" value="30S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048584">
        <property type="entry name" value="Ribosomal_uS5m_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21251">
        <property type="entry name" value="Ribosomal_uS5m_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="177"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8196686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="428" mass="48273" checksum="7BB62F1E195E0907" modified="2024-11-27" version="1">MLACRSVALNLYNKINFTAYIRSLNLPANDSALKSVYLPTLSTWRSSHAFLSRLKAEQLWKGVTSVSSAGRKKGRGRGAGRKLARDLNRGQVIGFGKTNMLWPGLNAPVIQGREVVRQQELPPDENREKRLFELRDKMASKKFNKIHPLERGWSGTKLHGRSLGPPEPVGEETFEGFDSRVLQFKPVMHMTGDRGRVRRMSAIVVVGNKKGLAGFGVAKSVNPMSAAKTARNRAAKLLRYIELDGSTVRHDFYCEFGAVKVFVEKRPEGFGLTAHRLIRAICEVLGIKDLYAKVEGPTDNYLNLTRAFFIGLMTQKSLQQIAEEKGLHIVRMSEDQDNFPVVVASPTKCRTEAEIGENEQVDFHLHLHGGRVVEPRKKYQPFYINFPTFIKEMEIRQFQRNQKGVVIDLLAKYGAITSHLQLKEGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLZ5</accession>
    <name>A0AAV6VLZ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_027546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLZ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="3">
        <location>
            <begin position="64"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="64"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8196832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="291" mass="34330" checksum="9585A557148E1EE0" modified="2024-11-27" version="1">MAVKLDEELRNDFKWLIDDFNLHAFGMFDIDGTEVDGHRKRSGTDNAWNKKEKRPILRKSGVKRRTFSVTKRYCEIIERCLSEKGELPARNIHKWIAENFPGLKLTDRTWKNKVSYSLTTNPIFKKKKLAFGSGSRNVWYMDKELFKPLKTEVQKSLYHKNFLYPKKENSKRNYGFQNKILTKPTPKKALIKKEELPSEDFIKFSGVSPTNLKQNVEMDSYSFGTQNLFHTSIYDSGSFNTMIEECRIEPEEYYELEVPIPKYLVEKNAYEDNMEVKYFFDESNAMTLEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMH0</accession>
    <name>A0AAV6VMH0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000045">
        <property type="protein sequence ID" value="KAG8198012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMH0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="562" mass="64852" checksum="397B3FAEC15642DF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP85</accession>
    <name>A0AAV6VP85_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_017368</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="JAFNEN010000039">
        <property type="protein sequence ID" value="KAG8198502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP85"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8198502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="648" mass="73678" checksum="B80F87D3E6C3958D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPY0</accession>
    <name>A0AAV6VPY0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000053">
        <property type="protein sequence ID" value="KAG8197576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPY0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8391" checksum="6A8B638081878511" modified="2024-11-27" version="1">MIGSVVPDVTSWRPQSDVVPGDGDNREKLYGVMGKKWEGTSSKMVDASHDQATVEMKEEIVLAWILLGKLLTSVSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQ73</accession>
    <name>A0AAV6VQ73_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_021529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQ73"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF342">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR 28DC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8198275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="359" mass="40321" checksum="CCE32630D0DE4319" modified="2024-11-27" version="1">MSGFNLLSQNSHQGTVLYSAFSVYNILMIAHLGSRGKTSQQICSTLGICHFNKTTIHEAFGQLCKDLTADKTLTDSLEIANGLFVQRGYNISRYYEYGLKHFYSSSLTEVDFHNSSTSALNAINSWVRQSTKGKIHAVIHKIPNHSVKVMMVNAIHFRSQWKWQFNPQSTEPNGFFYVTPHHRVQVPIMSGKMLVALGHDSEIGARILELPFVQPRVSMFLILSDNPRNTVQLNVTSLKHLISTMKKQEVNIRLPRFTVDLSPQLTGLLWTLGIKDIFSPTEADLRGISDGLFVTDIVHRALIQVDEKGSQASAATVALVERIGHVDEQYFEANRPFTFIVMDKKYGAVLFMGRIASFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQ99</accession>
    <name>A0AAV6VQ99_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_020277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000047">
        <property type="protein sequence ID" value="KAG8197898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQ99"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000743">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF564">
        <property type="entry name" value="MACROPHAGE-STIMULATING PROTEIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="537"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8197898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="819" mass="90185" checksum="56CACAC56A1913A4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRT1</accession>
    <name>A0AAV6VRT1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_011832</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000028">
        <property type="protein sequence ID" value="KAG8199372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRT1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="14">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="14">
        <location>
            <begin position="177"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8199372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="864" mass="96987" checksum="3910B50DCDAC1449" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWI8</accession>
    <name>A0AAV6VWI8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWI8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8561" checksum="1256A4A56494E788" modified="2024-11-27" version="1">MSCNLSNSLTGHQAINQVAFASNKVTDLNLCQTREKVSLLSLHKPPVVSVAEKESFWIYSKSDDRMNGIVCLEGRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWJ4</accession>
    <name>A0AAV6VWJ4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWJ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="98" mass="11195" checksum="038883DA60D10F67" modified="2024-11-27" version="1">MRKKVQTSGLCIKQATNKRLPHLEVIVSAERQEFESNGTLAAQVYLFNMFLTSKTKYLTRLLSTTFTNRKKRTNSRRSIANFALILRPQAILCSEVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXR8</accession>
    <name>A0AAV6VXR8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_019888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000007">
        <property type="protein sequence ID" value="KAG8201250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXR8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="24"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8201250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="9216" checksum="66D4FB8F80346ACA" modified="2024-11-27" version="1">MATYKDTMKPGMDEGQSWLNHRIRITLTSLNVKSLEKGEYFLLQDLIKGKEKELKVKGPVRMPTRILRITTQTHGEVSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXX9</accession>
    <name>A0AAV6VXX9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1956" mass="222508" checksum="6C60588F5003B5F0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VY90</accession>
    <name>A0AAV6VY90_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="5">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_006374</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000013">
        <property type="protein sequence ID" value="KAG8200792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VY90"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000013">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000019">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000001">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000012">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037919">
        <property type="entry name" value="OGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 12" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="370"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="438"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="13">
        <location>
            <begin position="485"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8200792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1049" mass="116452" checksum="117087756E866000" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W0W0</accession>
    <name>A0AAV6W0W0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_012690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W0W0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8201620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="157" mass="15986" checksum="199516AAFF285732" modified="2024-11-27" version="1">MAEDAPVYSVFFGVMGSAAAMVFSALGAAYGTGKSGVGISAMSIMRPELIMKSIIPVVMAGIVAIYGLVVAVLIANSIKTPEDGYKPYNGFLHFGAGLSVGLSGLAAGFAIGTVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILTVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W3W2</accession>
    <name>A0AAV6W3W2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_010447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009039">
        <property type="entry name" value="EAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005492">
        <property type="entry name" value="EPTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15261">
        <property type="entry name" value="THROMBOSPONDIN-TYPE LAMININ G DOMAIN AND EAR REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15261:SF4">
        <property type="entry name" value="THROMBOSPONDIN-TYPE LAMININ G DOMAIN AND EAR REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03736">
        <property type="entry name" value="EPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50912">
        <property type="entry name" value="EAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043686616" evidence="3">
        <location>
            <begin position="18"/>
            <end position="2219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8202085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2219" mass="249092" checksum="3A6867D9B264F65E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W4C2</accession>
    <name>A0AAV6W4C2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_010501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W4C2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF25">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8202142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1171" mass="133006" checksum="439A5E546D5B456E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TE52</accession>
    <name>A0AAV6TE52_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006280">
        <property type="protein sequence ID" value="KAG8156142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TE52"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8156142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="95" mass="10597" checksum="6CAAEE4DC9866B24" modified="2024-11-27" version="1" fragment="single">ALEGVDNTGESALNNLRLTSKLAKKVGCPDNVRDNPQVTMACLKGKFRKLKMKNALPSLDQIVIQLFPGKHQTLKMQMKRFYLHSANSRSEVLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TF43</accession>
    <name>A0AAV6TF43_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microtubule-associated protein RP/EB family member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005504">
        <property type="protein sequence ID" value="KAG8170414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TF43"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13582" checksum="0B473BE26A0710DB" modified="2024-11-27" version="1" fragment="single">HIPVDKLIKGRFQDNFEFLQWFKKFFDANYGGQDLRPPGGQERHDDGCGREGRRRRHDQQVRVLQQARPKCLSEQVHCKSSPIPTRRHPTSLQNSSPESDKQAGRGRPPEDGRAHWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THW0</accession>
    <name>A0AAV6THW0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004218">
        <property type="protein sequence ID" value="KAG8171268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THW0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="66" mass="7314" checksum="B6D9C40F60F321C3" modified="2024-11-27" version="1">MVVTGDGESGLHPEREHVRKRHHIQGSSRRAELPTPGTGMVVTKMNDTGTLLEITQYGMSYHSIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIC4</accession>
    <name>A0AAV6TIC4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004284">
        <property type="protein sequence ID" value="KAG8171226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIC4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="107" mass="11798" checksum="792DFE53FE53BBC4" modified="2024-11-27" version="1">MSPMKGVGSLAVGRCHGSRNFAKECVTTHRPKQLALKMVALHVWAYTGRYGRASLVEFSQESEVNRKKGPKKKEKVACVEGAGREPAWEPPHTVQILVVSSKYSSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJ30</accession>
    <name>A0AAV6TJ30_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003607">
        <property type="protein sequence ID" value="KAG8171742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJ30"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="1">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="56" mass="6294" checksum="75577F5CA1548AB2" modified="2024-11-27" version="1" fragment="single">MQGLYTDSSGETVTVAVKTLKDNFNQDAQTDFEREVEIMSSFSHENILKLEGIVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJA3</accession>
    <name>A0AAV6TJA3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003665">
        <property type="protein sequence ID" value="KAG8171693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJA3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="144" mass="15608" checksum="F8E77D90C7E9A816" modified="2024-11-27" version="1">MTNKSTQIPEVIDIEDNLCPIEDDSFPILRYLLTARELINMPATDMPATNMPATNMPATDMPATDMPATDMPATNMPATDMPATNMPATDMPATDMPATDMPGTNMPANNMPGTDMPATDMPATIHINIPGTNMPIWIIELKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLE5</accession>
    <name>A0AAV6TLE5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_019965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002855">
        <property type="protein sequence ID" value="KAG8172291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLE5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8172291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="161" mass="18654" checksum="58B8DA4FF9303ED3" modified="2024-11-27" version="1" fragment="single">RSSLIVDGLRFPPHYTEENVKSAQNYRPRDDDVIVVTYPKCGTTWTQVILSLIFTQGEPEGAKKLFAASPFLERQGSKEAETMARPCILKTHLPFGRAPWSDKAKYICVSRNPKDCCVSYFHHFKARTYSGDFNHFFETFLEGSVYYGDYLDYLMGWEEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMD2</accession>
    <name>A0AAV6TMD2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002232">
        <property type="protein sequence ID" value="KAG8172929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMD2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="139" mass="16621" checksum="79496AA894E0C054" modified="2024-11-27" version="1">MTVAWSSVGRCDTVNILWVEIYLPPETPPSPSQAAPFLHKHTLLFQITLFLLHRHPLLLQRHTFLLQRHLLLRQTQHLFLQRHICLLQRHPLPRQTHHLLLQWHHLLLQRHHSLLPWRGLITSQVQFFHPEASSQAHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TN39</accession>
    <name>A0AAV6TN39_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001965">
        <property type="protein sequence ID" value="KAG8173230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TN39"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="142" mass="16470" checksum="0C46EAD1D03036E8" modified="2024-11-27" version="1">MFVSLQIPVTEWSNGRMNGREIKVVGVSRKRDNCVKKKCFPMPDRIFRGLACLKCKAVNYCKCGCMSWKAKQKESYMPLVRPDGGWETVTEKDWKPWKRGVYFEETLRNHYFSTNKDARVSKDGQHERTAKGFDQPSDSHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNJ5</accession>
    <name>A0AAV6TNJ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001840">
        <property type="protein sequence ID" value="KAG8173362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNJ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026095">
        <property type="entry name" value="Myb/SANT-like_DNA-bd_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22666">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22666:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8173362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="180" mass="20227" checksum="DDEEA45683D0E47C" modified="2024-11-27" version="1">MASKDKPRRRNWGDPEIQLLIDVWRVHNASLLSARRNRHVYDQMAQELALYGIVRTHDEIALKIKNLTATYRKEKTLQGVTGGQPSEWGFFNDVSAILDQLPCNTNSLVQDSLFRNHGSDDPSTSGYISKENKRMVEEDEESLLVDADMNMDESAEEGMPALDSIPNLTPGPDTVEVVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPJ1</accession>
    <name>A0AAV6TPJ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_003074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001442">
        <property type="protein sequence ID" value="KAG8173895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPJ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="91"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8173895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="70762" checksum="05B769931AF59A11" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQ22</accession>
    <name>A0AAV6TQ22_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001528">
        <property type="protein sequence ID" value="KAG8173711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQ22"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="52" mass="5957" checksum="B391C4ACF2856CEA" modified="2024-11-27" version="1" fragment="single">INTTVDEDWSISLYHITVIVRRRRTQHMFTGAVRVHPKGKSPVGVKTPGREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQ51</accession>
    <name>A0AAV6TQ51_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001510">
        <property type="protein sequence ID" value="KAG8173741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQ51"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="204" mass="23181" checksum="9099B753BADB3163" modified="2024-11-27" version="1">MHLIKRPSSSAEANAIIEMDKYLAQYHPLSIVLNSLVLISFEKWFYVVEFFGEYSVGVIPCNRILLESVETDETGKPVRSNCWWPPVKSVSKLVMTRVRPNTSTWRIFEVKLVKAYDSYEKARVKSIRYLSESDLNTASENDVNIYFKKRLPPKFPKRSAAGVGCSRRNQPSGSQIISLAGSSQSRLMTENAFPRHPAYQSPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQB4</accession>
    <name>A0AAV6TQB4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001470">
        <property type="protein sequence ID" value="KAG8173838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQB4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="194" mass="22524" checksum="F8547E35ACFE146F" modified="2024-11-27" version="1">MKRPHEDTVSDSDEEDEAPSPKNKPTPESVILQDLERGLQQNDPTSMQQQLIETQKQYFTMYMNKLMHQLPMGKAIIDTVRKNGHDDDFMYMYTASKTIVQSIMSVKQHKAMKSMVDMVAGIACKYMHDKILTPMLKPIMDEEHLQQAFQAYQTSVNQEENDSELEMRCLLHTIHSILEKEESTLQLDSPFLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQF6</accession>
    <name>A0AAV6TQF6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_016335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010001470">
        <property type="protein sequence ID" value="KAG8173846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQF6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="7">
        <location>
            <begin position="604"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8173846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="830" mass="94725" checksum="0736D08F03B54EE5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TR04</accession>
    <name>A0AAV6TR04_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_025033</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010001219">
        <property type="protein sequence ID" value="KAG8174435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TR04"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="112"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8174435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="339" mass="39621" checksum="68EE64F37101464C" modified="2024-11-27" version="1">MLRYFNQFGISPTFSLKYVLTFAAGTIFGFTYFHIWIDVSRWKSGNAFPTTDSRADYLYTRDVKKFQNNFKIYRGYLPIVYEVDRSVADVLAQRVRILCWVVTDPSGFDQAKAIKATWGQRCNALLFTSTKASKKLPTVMFNMTTDWGKTKQGLKYIYENYMDSADWILKVDVHHYVIVENLRHMLEPHSPDSPVYFGRQFHRHTTQGYMSGGAGYVLSRAALRRFVERGLNKPTLCRSDDGGLEDVELGICLKHSGVAAGDSRDRYGLGRFFPFDPATHIVKDLRDEEIRWYWEFSNISYPERIDCCSETTIAFHYVFRPFMYNYDYFLYNLHTRLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TR22</accession>
    <name>A0AAV6TR22_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001353">
        <property type="protein sequence ID" value="KAG8174024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TR22"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48257">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48257:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20853" checksum="D14EEC5B73BC4E73" modified="2024-11-27" version="1">MRHKVQHPNDKNRFLFLSFDPCHIIKNIRSQFLEKEMGGKESYITGNYVKKVYELQKDQTGWKLSSPLIWKKSKKESEECEKDFLTPETYSALLLTSLSTVACVKYLLENGFHYVLTRRRDPVESLFSAVRQMNGGNDGSDAKASTVAINKILRTGLLLPHHSSNVPVSSFETFHNLALPGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRJ0</accession>
    <name>A0AAV6TRJ0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_005897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001294">
        <property type="protein sequence ID" value="KAG8174178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRJ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22754">
        <property type="entry name" value="OTU_wMelOTU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="50"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8174178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="868" mass="99043" checksum="EBABB931F006693B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRN2</accession>
    <name>A0AAV6TRN2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001288">
        <property type="protein sequence ID" value="KAG8174212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRN2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="158" mass="16938" checksum="FE98A79A44093566" modified="2024-11-27" version="1">MNGGNDASDAKAATIAISKILRTGLLLPHKSSNVQVGNLSSNCMLVKRNKESGATVTTISDEGMDILTKLDTFNGYVPASMCMASLAYVAGYLIRVLEREIPCIDCLRELSVASCSSPLLSIVKALYTRKPSSPTKMFSPKHCHLSDYECSSGRGDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUV4</accession>
    <name>A0AAV6TUV4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_012205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001008">
        <property type="protein sequence ID" value="KAG8175413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUV4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000013">
        <property type="entry name" value="Class II aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005451">
        <property type="entry name" value="PRK07044.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="3">
        <location>
            <begin position="140"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="732"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8175413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="778" mass="88047" checksum="0CBBA9EF13EC29C6" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVC0</accession>
    <name>A0AAV6TVC0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_020778</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000930">
        <property type="protein sequence ID" value="KAG8175995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVC0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031984">
        <property type="term" value="C:organelle subcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09258">
        <property type="entry name" value="AP-1_Mu1A_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000002">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="12">
        <location>
            <begin position="200"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8175995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="455" mass="52248" checksum="04907F5DDC6D2DCC" modified="2024-11-27" version="1">MPFTRDRKSVPTLLGFGKAIEINITAEPQIRFRMSASAIYLLDLKGKVLISRNYRGDIDMSAADKFMTLLMDKEEEGCITPILSHNGTTFMYIKYNNLYLVATTKKNANVALVFVFLHKIVQVFIEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEFITQESHKMEAQPRPPMAVTNAVSWRSEGIKYRKNEVFLDVIESVNLLANANGNVLRSEIVGCIKMRVYLSGMPELRLGLNDKVLFESTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIERHAHSRVEYMVKAKSQFKRRSTANNVEIIIPVPTDADSPKFKTTVGSVKYAPEQSAVVWSVKSFPGGKEYLMRAHFGLPSVESEDLEGKPPIQVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWF8</accession>
    <name>A0AAV6TWF8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000950">
        <property type="protein sequence ID" value="KAG8175757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWF8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="348" mass="39665" checksum="FEDA0A843CC821AB" modified="2024-11-27" version="1">MMCPLKNCNRMYEKVKSFSSHLTRIDWNAINTMKIQNYSECDSVKDTSVHSGVMESVNIAIEGTSSYSEVLENTAFQESSEKLWQEFKKKLPTSPRKKIAVIEKLATDTGLLIKKKSNSANALDENVKNSVADFYVRDDISRQAPGRKDTIVIRKDGKKTKHQRRHLYTVLTEVFQLLKIENPNIKIGFSSFASLGPQHVLLSSETQPNVCVCIYHVNIEFLTCSINKMLPIVPSKSKELVAKLVCSTEQEKCMLGNWVVCKDKYEALTSDVQNGSELISWYAWDSNSERRTVKTVKEGTLDDAINTLEEQIPSFLEHCFIKQSQSEYFQDSKKNVSEKKMFTSSRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWN8</accession>
    <name>A0AAV6TWN8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000950">
        <property type="protein sequence ID" value="KAG8175771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWN8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="216" mass="24347" checksum="C3F820E04269290D" modified="2024-11-27" version="1">MALLLEALKLGKSRDLIKDSVCDAGKEACMLSLCLNCANVYDSLKSKIPEEDHSLYMQWKKVEGRLKIVDNSGSMLDAADEVASQFQKFKKHCFVKDVQDGHFQSVKGNLVEVDESTDASSFEKFIMYVKFIDSDATTKFLALRNVESGTADALKSLLLDVLKEFGIDLLIINEVQKKRREIQELSEIMAEEENSASYSPKNIQGTRWIDHKKRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXA3</accession>
    <name>A0AAV6TXA3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000862">
        <property type="protein sequence ID" value="KAG8176635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXA3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="228" mass="26368" checksum="59271E9CF261BDD6" modified="2024-11-27" version="1">MEGLSPNDLIRFIFTANELDRPISTFLLRVDDMIVEVLLSCNTRDLQSKDTITLDEGFFINVIKIIRPIGAGRNRRVVNPEVDRFKKGRSRVAHPKRRSCNLLKRRAMLLHRNTGIPEGPCRLEEVAIFERFLQVQIIVICSAEMQKVVYKGPGEKPENNLWLHDNHFDLINSPKGFYGSDCYCEHCNSPYKRVEAHMCEELCYICRKADCKNRLSFSMCSMQLQVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZV0</accession>
    <name>A0AAV6TZV0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_023608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000789">
        <property type="protein sequence ID" value="KAG8177291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZV0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="65"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8177291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="183" mass="20806" checksum="03167029ADA5D876" modified="2024-11-27" version="1">MEPNNVNASHNVTHVIVTKGPPVTSKVRRLAPDKLKIAKAEFDYMLEHGICRPSSSPWSSPLHLVKKKDGGWRPCGDYRALNAATLPDRYPIPHLHDFTHQLEGTTVYSTLDLHRAYHQIPMELSDIEKTAICTPFGLFEFPLMTFGLRNAAQTFQRFMHSVLRGLEFCFVYLDDILIASRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U001</accession>
    <name>A0AAV6U001_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000766">
        <property type="protein sequence ID" value="KAG8177645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U001"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF6">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12668" checksum="60BC78DA0971447E" modified="2024-11-27" version="1">MDIHKNYSHAGSQMMRSVLREHYWILGGCHTIRAVINQCQACRRFKAKKLETVPNPLPEDRVREAKVFEVLGMDFAGPLYVNTGAKMSQKVWICLFTCAVYRAVHFELIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2C8</accession>
    <name>A0AAV6U2C8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cathepsin L</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_017459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000717">
        <property type="protein sequence ID" value="KAG8178112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2C8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="66"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="151"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8178112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="40683" checksum="843A9A10A9D383C2" modified="2024-11-27" version="1">MAKKVDACQTLAESYQCKRRCIHTSILPLLTLFTKTMALKLSLVAVLMFVAINCVASFDSNLDDHWYNFKKTFCKVYKQYEESPRREVFEMNVRSILKHNLEHDLGKHTYRKGLNQFADVLHYDFVKQMNGYKGVRVNNSTAPFPQINTTVPTTVDWRDKGIVTPVKNQQQCGSCWAFSTTGSLEGQHALKTGKLVSLSEQNLVDCSGPEGNMGCEGGLMDQAFDYIEQNGGIDTESSYPYTAQDGTCHYKKASSGATCTGFVDIPTGDEEALKKAVATVGPVSVAIDASQESFQFYQGGIYSEPQCSSVQLDHGVLAVGYGTENGQDYWLVKNSWDTTWGDNGYIKMARNQNNQCGIATQASYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2E3</accession>
    <name>A0AAV6U2E3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_025246</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000715">
        <property type="protein sequence ID" value="KAG8178133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2E3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8178133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="343" mass="38346" checksum="9947F761AC3305F0" modified="2024-11-27" version="1">MLTFSRRRPVTLSGFRTRATSRDTPCSSRYGPHFSRKPSPGDIHTPCAWDAAPLVLEGHPYPVLVFSHGLGGCRTTYTTFCLEMASRGIVVAALEHRDYSACMTFYFESQEGEEKMNKRWMLFKKVKSGKGEFAIRNQQVHQRARECSRALDMLSDLTCGLPVHNVLATSSLRLDAFAGLLDIDRACAAGHSFGGATVIAAMAEDKRFKAGLGLDTWMLPLREETSVFAHVEQPMLFVNMEKFQTKENLRVMKQVQTQSPLKKVVTLRGTVHLNQCDVPFLCDGTMRRMFGASSRLNRFTAMQLTTNLCGAFLSKHIDIPTDAKYTTHIQQHSSVIQEGITSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2V6</accession>
    <name>A0AAV6U2V6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000735">
        <property type="protein sequence ID" value="KAG8177924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2V6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="327" mass="37139" checksum="59BC2284A9409E7B" modified="2024-11-27" version="1">MLVSWSAFEALNANIELFGSEFSPVKDEVEEELHPVALSNEISSIGNDTTIGKRRLFVQLQKEDETLKGAWDLAREKKENFGVQDEVLIHTEVVGGEEIQQVVLPWEVPHSTTGVSPFQLVYGRIPRGPLGLIKDAWTGESDIPTGASSSIEKYIDDLQERIRTAHKIAAGNTERAQESYTSRYNLRSKEKTFVVGEKVLVLIPSSSHKLLKTWFGPATVVQLTRPHSALIEFDDKSRREFHFNKLRPYIARVEQVGLIFEQDEEFGDISYAPTSKKERSFCDIQKHMHGQEVDVTREQKEELAVSLTNTLMYLTKFQGKPKFQAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3E1</accession>
    <name>A0AAV6U3E1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_024649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000693">
        <property type="protein sequence ID" value="KAG8178489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043462285" description="TIL domain-containing protein" evidence="4">
        <location>
            <begin position="16"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="1570"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="1629"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="542"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="814"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1446"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="596"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="834"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1023"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1455"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1469"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1479"/>
            <end position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8178489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1762" mass="190248" checksum="8F67991B5713195C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U418</accession>
    <name>A0AAV6U418_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_024646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000693">
        <property type="protein sequence ID" value="KAG8178486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U418"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8178486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12411" checksum="E6D06780BF93FBFF" modified="2024-11-27" version="1">MCGSSQISKCTKPVLAIRREELMWKRRAPLSADHVRELCQKDIKVIVQSCNRRVFTNESYSNAGAEIREDISDASVILGVKEVSIEHLLPDKTYCFFCHATKGEPQNTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U477</accession>
    <name>A0AAV6U477_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Kinase suppressor of Ras 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_024141</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000639">
        <property type="protein sequence ID" value="KAG8179292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U477"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20812">
        <property type="entry name" value="C1_KSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14063">
        <property type="entry name" value="PK_KSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000061">
        <property type="entry name" value="Kinase suppressor of Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000107">
        <property type="entry name" value="kinase suppressor of Ras 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000034">
        <property type="entry name" value="Kinase suppressor of Ras 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025561">
        <property type="entry name" value="KSR_SAM-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046861">
        <property type="entry name" value="SAM_KSR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046933">
        <property type="entry name" value="SAM_KSR1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF253">
        <property type="entry name" value="KINASE SUPPRESSOR OF RAS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13543">
        <property type="entry name" value="SAM_KSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20406">
        <property type="entry name" value="SAM_KSR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="382"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="613"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="173"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="221"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="292"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="440"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="543"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="639"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8179292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="907" mass="101355" checksum="A2F3C0BA9DBA9DCB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U584</accession>
    <name>A0AAV6U584_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_015377</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FRAS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000665">
        <property type="protein sequence ID" value="KAG8178824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U584"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF11">
        <property type="entry name" value="FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="repeat" description="CSPG" evidence="7">
        <location>
            <begin position="70"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="7">
        <location>
            <begin position="193"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="7">
        <location>
            <begin position="310"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="7">
        <location>
            <begin position="426"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="8">
        <location>
            <begin position="1019"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8178824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1134" mass="129241" checksum="BF44FF6006C65961" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5P9</accession>
    <name>A0AAV6U5P9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatase and actin regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_013112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000656">
        <property type="protein sequence ID" value="KAG8178955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5P9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8178955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="67954" checksum="59E1143AB2EDF8C2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6C2</accession>
    <name>A0AAV6U6C2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">THAP domain-containing protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_006635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000606">
        <property type="protein sequence ID" value="KAG8179730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6C2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP9-like helix-turn-helix" evidence="1">
        <location>
            <begin position="6"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="2">
        <location>
            <begin position="55"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8179730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17409" checksum="64DFFCF015F9C0B4" modified="2024-11-27" version="1">MAHLTRGKYPPALRAFALTLQFYFSRAYDYVRTTFKNALPHPSTLRKWYCGIDGESGFSSETFKILESMATNQTKIIVCAIILDKMSIMKRVQYDRKRYRGFVDIGTGEDPDDDTPLAGNALIFMLVSLDSHWKVPLRIFLLMACLEEKGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6J2</accession>
    <name>A0AAV6U6J2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000640">
        <property type="protein sequence ID" value="KAG8179270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6J2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18368">
        <property type="entry name" value="BTB_POZ_KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17073">
        <property type="entry name" value="KHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.80:FF:000002">
        <property type="entry name" value="Potassium channel tetramerization domain-containing 9a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021789">
        <property type="entry name" value="KHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051082">
        <property type="entry name" value="Pentapeptide-BTB/POZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136:SF17">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11834">
        <property type="entry name" value="KHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51490">
        <property type="entry name" value="KHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KHA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="404" mass="44455" checksum="93D292780AC7BED0" modified="2024-11-27" version="1">MQRITVFKNGSSNSGKLVELKDSLDVLVKLINEKLGVEGKILFTANGGEVDDIELIRDNDVLYISNGEPFIDPLIINKRNVPPQKKEVGTIPNTSFTNPDWLLLNVGGKHFATTRSTLITKEPNSMLACMIASEDSALLCPSSIDDYGAFLIDRSPVYFEPILNYLRHGQLVLDKNTNPRGVLEEARFFGIESLVKILEESVEEEQEVVDDCAPLTRRDVINSLITTSYLSELRFQGVNLSHADLSRLDLRHINFKYANLHQTKLSGTNLSYCCLERTDLSQANLEGAILLGVKMLCANLEGANLRSCNMEDPAGHRANMEGVNLKGANLEGSQMAGVNLRVATLKKANLQNCDLRGAVLAGADLENCDLSGSDLHEANLRGANLKDTAFELMLTPLHMSQAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6U7</accession>
    <name>A0AAV6U6U7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000598">
        <property type="protein sequence ID" value="KAG8179879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6U7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10555" checksum="BCA240E493DD71F2" modified="2024-11-27" version="1">MSPFSPQLPPHIVLSSVSRVRGSLVAAAAGERQRTPDPRRARCGFAPEQLIRPSREEVDEIFWKKITQPLFNHECRTTLPRPPRSAQKEKPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U702</accession>
    <name>A0AAV6U702_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_025263</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000596">
        <property type="protein sequence ID" value="KAG8179939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U702"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000965">
        <property type="entry name" value="Neurotrophin receptor-interacting factor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8179939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="334" mass="38918" checksum="4C4C96666C6A7555" modified="2024-11-27" version="1">MKMVEYINNSEIIGQVLYSEIVDQMPQSSALFAMILLTRGKNFVNIFSNIPKATSVQFVRRNSLNVLHFIHTSSFTLDRNALGKNVSTEPCDMVSPKQSVICEVCGKLLSDKHYLRKHQLIHTGEKRHQCQVCNKKFTLKSQLNAHLQLHNDKEKRLLCELCDIQFHVKEDLRKHLLHHQGKQPYRCGVCHKEYSLKSQFKIHLLKHSGEKPYLCDICGKQYADMGKLKAHQVFHTKNKRYPCKFCSKQFLQKEILNGHIQTAHVGGKIYYCPVCNKEFNLKSSLDNHVFRHSRDKIHSCSFCKKQFTAKKELRKHFVVHKGEKWLDKNLSCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7B9</accession>
    <name>A0AAV6U7B9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_025080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000605">
        <property type="protein sequence ID" value="KAG8179748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF40">
        <property type="entry name" value="REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="932"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8179748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1336" mass="149623" checksum="2E567351B1ECBA1B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7E4</accession>
    <name>A0AAV6U7E4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000604">
        <property type="protein sequence ID" value="KAG8179753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7E4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="328" mass="39624" checksum="513D1503DFC8EC89" modified="2024-11-27" version="1" fragment="single">RKRKEGRRRGGGEERGEGRGREKGGRGRERGERGERRRREGGEEERGEEREKRRKREGREREEKGGREKGRGEREEGGGGKKGGKERKEKGEKEGREEREREREEGEGKEGEREEGEREEGGEEREGEGGEKEGEGEERRKEKKREEGKEEKRERRRREREGEEREGERERERRGRREEKGEERKERKEERREEEEKREREKEGEERREERGKREGERGERERRREEGGRGREEREERRKGGREEGGEEEKEGEGRGEREGRRRERKEEGEEGERGRGRRRREKREGEREREGEKRRGREEREEGEGERGEREGEEEKRRGAIGKYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9G1</accession>
    <name>A0AAV6U9G1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_005925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000547">
        <property type="protein sequence ID" value="KAG8180839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9G1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="105"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8180839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="374" mass="41601" checksum="626D17197819E8E6" modified="2024-11-27" version="1">MEDDSEDFYQALTRHLRLFSSVLWTFPVRHVSGLFGTEGAVGSSKLEISLSVFAIATFLLVLYQSVELVRRMVLARALLRARRGRSSLPLFPRERDCWELEQGPSCGLCALKGRRPRMEDRFSIIEDPASGIALYGVFDGHGGEFAADFVEKRLFKELLKKLQAAVLEKGKGSSCVTEEFVRLLTAQILDLDKELLLKVKAARDVAGTTALVAIVYKNKLIVANVGDSRGVICDSKGNTIPLSFDHKPDQLKERKRIKDAGGFIAYNGVWRVAGILATSRALGDFPLKDRNLVIARPDILTFDLATLRPRFMILASDGLWDTMSNEEAVAHLVKDNGHRALEDARSLSHHAFKSGSQDNVTVLVVRFSEEKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9X5</accession>
    <name>A0AAV6U9X5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_017642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000573">
        <property type="protein sequence ID" value="KAG8180241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9X5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14514">
        <property type="entry name" value="DUSP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052103">
        <property type="entry name" value="Dual_spec_Phospatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961:SF6">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="64"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8180241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21608" checksum="D13E1EA46BD886A9" modified="2024-11-27" version="1">MLSELNEVTDHLFISSMRSVNVAALQRKGITCIINCSLLVPNYEIEAFRYVPITIEDNEKADISQFFEEVSCIIHEEHAAGGRTLVYCVAGISRSATLCIAYLMKYQDMTLRNAFRHLRSRRRIIRPNNGFFQKLIEYERHLYNQTTVEMVRVPNADSPDCLVPDVFYEVCKGIVWLRSNKKYFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCB1</accession>
    <name>A0AAV6UCB1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000513">
        <property type="protein sequence ID" value="KAG8181493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCB1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="274" mass="30791" checksum="263C444CBBB73E24" modified="2024-11-27" version="1">MSLRPYIGLLSEYQKEYLNYSGKDCSLTKRRNLAAGVPSLPSPDCRPKEYSSEDGLLPVFHGKSVAKSDYVPQPRIARTQNFKVECSTKEAGTKNEAGINGSAQIKPDRPPMLLLPGMQETESEAKASYRPFPLELARSEGTPFLRTKNGEPENRAPRWDLTSSYQADYCGIRTQPRRICLEERSAHHKDTSCKYNTSNSSKLEGQTCKQNCKENVHDQLSSYVKSLLFRTTTGSAYRPPSTFRGPPCHPAKEQKCPAEDILPQKCEIHCKQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEV9</accession>
    <name>A0AAV6UEV9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000456">
        <property type="protein sequence ID" value="KAG8182635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEV9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="140" mass="15602" checksum="949D7C6371AADF19" modified="2024-11-27" version="1">MPWLCQKGVTNAPAEFTTQIMFSHFISGLRQDIKTQIHIQNPGDFAEALQTAIRIEKAFKDTTQNVNCFEASASAATRAHEADKNAFITGVEALTNRILFGKTSRGFSIKKGNLKQTQISLSILQQRGSLHRRLQKEALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF45</accession>
    <name>A0AAV6UF45_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chromatin-remodeling complex ATPase chain Iswi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_014550</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000478">
        <property type="protein sequence ID" value="KAG8182135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF45"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000022">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000049">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000001">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1190:FF:000002">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000101">
        <property type="entry name" value="SWI/SNF-related, matrix-associated, actin-dependent regulator of"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="191"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="486"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="13">
        <location>
            <begin position="842"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1017"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1041"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8182135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1056" mass="122781" checksum="2CF22A71D2F7E846" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF97</accession>
    <name>A0AAV6UF97_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_024612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000443">
        <property type="protein sequence ID" value="KAG8182869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF97"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000002">
        <property type="entry name" value="cellular nucleic acid-binding protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8182869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="182" mass="19745" checksum="EA5BF439914BF9DE" modified="2024-11-27" version="1">MSSSECYKCHKTGHFARDCPSGGDSRGGGGYRGDSRNSSRVSCYNCGRSGHFARECRESDKTCYTCGKAGHISRECDQDERRISCYQCGKSGHVSRDCPGERDSRDDRKCYSCGDSGHISRDCPEGGNNQGGGGGGGDSEDTVCYRCNEKGHIARNCSTNRPNKCYTCGEVGHIARECEMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFE4</accession>
    <name>A0AAV6UFE4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">dTCF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_020388</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Binds to the beta-catenin homolog arm or to gro.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCF/LEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000461">
        <property type="protein sequence ID" value="KAG8182469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFE4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990907">
        <property type="term" value="C:beta-catenin-TCF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007500">
        <property type="term" value="P:mesodermal cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072091">
        <property type="term" value="P:regulation of stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007435">
        <property type="term" value="P:salivary gland morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035277">
        <property type="term" value="P:spiracle morphogenesis, open tracheal system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21996">
        <property type="entry name" value="HMG-box_TCF7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000001">
        <property type="entry name" value="transcription factor 7 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024940">
        <property type="entry name" value="TCF/LEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373:SF38">
        <property type="entry name" value="PROTEIN PANGOLIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373">
        <property type="entry name" value="TRANSCRIPTION FACTOR 7 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="122"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
            <begin position="122"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="58"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="247"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="558"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="656"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="625"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="670"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8182469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="724" mass="82103" checksum="BF2E223337D20465" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGS1</accession>
    <name>A0AAV6UGS1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000419">
        <property type="protein sequence ID" value="KAG8183394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGS1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="96" mass="10534" checksum="281E7DCA35E86095" modified="2024-11-27" version="1">MHKKVNPHIIDSITNLEATSIKSSSPANNAAAANTKTTDMFWPYYADKSTSTYCLIPEQSDVYRIQSSATANNSAAVNSEVNYDEIYLLPSKRAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGZ2</accession>
    <name>A0AAV6UGZ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TTF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000441">
        <property type="protein sequence ID" value="KAG8182921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGZ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006580">
        <property type="entry name" value="Znf_TTF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00597">
        <property type="entry name" value="ZnF_TTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTF-type" evidence="1">
        <location>
            <begin position="99"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="253" mass="29378" checksum="01A4A324CBA02F60" modified="2024-11-27" version="1">MLTSNEFLFLVSLDWQQEQLLENTDSSNNKAIEKKHGLFVENKDSAHGTPCPGPFQHQLYDIGYAVGKILEDDKKLKFLDETWNPPVNFSFPTKAEGKQNRKFRYEWLQQYKWLAYSEYLEGGFCKMCVLFAPTGAGIGNQILKTFVKEPLSKYKKATEELKYHESTQYHQFSVEKALNFKDTFNSAPGSSKQHISYMLDKKKAAVVEHNRKRLKPIVKTILFCARNNLPLRGHRDDGKMNNEDCLDQWFSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHM4</accession>
    <name>A0AAV6UHM4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GTP-binding protein Di-Ras2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_004908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. Di-Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000424">
        <property type="protein sequence ID" value="KAG8183288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHM4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000303">
        <property type="entry name" value="GTP-binding protein Di-Ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8183288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22611" checksum="1C6CB5EBF235DCB9" modified="2024-11-27" version="1">MPEQSNDYRVVVFGAGGVGKSSLVLRFVKGSFCETYIPTVEDTYRQVITCNRNIYTLQITDTTGSHQFPAMQRLNISKGHAFILVYSVTSKQSLEELAPIFALIREVKVSLEGIPMMLVGNKSDEEEGTREVPYDSGLSQSHKWNCNFMETSAKNNSNVKEMFQELLNMEKSRNVSLQSERRTLAQFRKDKMKGKCMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHP0</accession>
    <name>A0AAV6UHP0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_002461</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4,8-dimethylnonanoyl-CoA + (R)-carnitine = O-4,8-dimethylnonanoyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:44860"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77061"/>
            <dbReference type="ChEBI" id="CHEBI:84654"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000399">
        <property type="protein sequence ID" value="KAG8183892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHP0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.20:FF:000001">
        <property type="entry name" value="carnitine O-palmitoyltransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF16">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="11">
        <location>
            <begin position="65"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8183892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="671" mass="76308" checksum="6EAB79EA550F4DB0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI35</accession>
    <name>A0AAV6UI35_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cathepsin C exclusion domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_013423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000438">
        <property type="protein sequence ID" value="KAG8182971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UI35"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.80:FF:000003">
        <property type="entry name" value="Cathepsin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.80">
        <property type="entry name" value="Cathepsin C, exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014882">
        <property type="entry name" value="CathepsinC_exc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036496">
        <property type="entry name" value="CathepsinC_exc_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08773">
        <property type="entry name" value="CathepsinC_exc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75001">
        <property type="entry name" value="Dipeptidyl peptidase I (cathepsin C), exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043888123" description="Cathepsin C exclusion domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin C exclusion" evidence="2">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8182971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="152" mass="16819" checksum="8171CB65BB2ADEC6" modified="2024-11-27" version="1">MASICMLALLAISVAYAGADTPANCTYEDIRGVWAFSEGERSGTQELECSTFKGPSVNSFKIELLFPNIAVDELGNKGYWTIIYNQGFEVVINYRKYFAFSAYKQGPGGNVTSYCDTIQPGWSHDVLGKNWACYNAQKVQPATPPKHHYTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJK5</accession>
    <name>A0AAV6UJK5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000377">
        <property type="protein sequence ID" value="KAG8184315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJK5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="104" mass="12240" checksum="20747DA72521D9ED" modified="2024-11-27" version="1">MEQKLDSPPPNDSPSKESRQLRPLDGSLERLLGGRRYSKQVGWTWFILVLDDRELSNRKEERPNKRTSRSWDDLLSADTTTAVAWREEFSVRQKLVLHETARHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULX9</accession>
    <name>A0AAV6ULX9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Hexosyltransferase</fullName>
            <ecNumber evidence="15">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_019323</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; chondroitin sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Golgi apparatus membrane</location>
            <topology evidence="2 15">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="15"/>
    <dbReference type="EMBL" id="JAFNEN010000363">
        <property type="protein sequence ID" value="KAG8184719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULX9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047220">
        <property type="term" value="F:galactosylxylosylprotein 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000018">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8184719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="357" mass="41394" checksum="8B9CC4867DEC4ED3" modified="2024-11-27" version="1">MPIAPRPNHDVSLLYAIISNVNFYVWPVYRYGEMKKLTEKVFTKSLVFYCLCAIVFVVGYFVGVLQCIGWCNEITYGKKLYQVEKQTAYLAVIIFSAPGNYERRRAIRKTWLLNKGDRSIGHFFVVGTASLESAELNNIQHEHEEFGDLMVLDKVSDSYAKLSVKLREALTWLYANVEFVFLLKVDDDSFVRLGALYNELKLKPKEKLYWGFFDGQAKVKFGGKWKETAWFLCDRYLPYAKGGGYVITSDLVRNLALTSSYLSLYQNEDVALGTWLAPFDIKRVHDPNFDTEYLSRGCFNSYLVTHKQSISLMITKFKNLKETGNMCTSERRERNSYMYNWRVQPSLCCIRNNSQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UM00</accession>
    <name>A0AAV6UM00_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000366">
        <property type="protein sequence ID" value="KAG8184661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UM00"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="376" mass="42028" checksum="6EA99B8068B0659B" modified="2024-11-27" version="1">MPNHMYLPAIQMQKYLPAIPNQQYLPAIPNTTIPTAIPNATSTYQPSQMQQLPTSHPKCNNTYQPSQMQQVPTSHPKCNKYLPAIPNATITYQPSQIQQVPTSHPKCNNYLPAIPNATKYLPAIPNATITYQPSQMQQLPTSHPNATITYQPSQIQQLPTSHPKYNNYLPAIPNATSTYQPSQMQQLPTSHPKCNKYLPAIPNATSTYQPSQMQQLPTSHPKCNNYLPAIPNATSTYQPSQMQQLPTSHPKCNKYLPAIPNATSTYQPSQMQQVPTSHPKCNNTYQPTQIQQVPTSHPKCNNYLPANPNTISTYLASQMQQLPTSQSKCNKYLPAIPNATITYQPTKCNKYLPAIPNATITDRRNGNARDEEEISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ00</accession>
    <name>A0AAV6UQ00_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_004395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000322">
        <property type="protein sequence ID" value="KAG8185853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ00"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="10">
        <location>
            <begin position="167"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8185853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="313" mass="36358" checksum="ACD997997DB329EF" modified="2024-11-27" version="1">MDKRSRNKENHRPSNNMCITDMFKVKKCLFDSSKSDFTSPKPASPILGCSPSFPEPQHESPYALFKVRKRASFKRSSGNNNETPHKRSNTVHDSNKKTFCTDVDMLSPDNSNKVKLAVQKSMAEHNLTGDFSKPCLLPLIEGKHPDLKCIAPETVADLLRGHKSLSFRIFDCRYPYEFEGGHIKSARNMYYKGTAEKDFFSTSVAAIQEEQKELLIFYCEFSSERAPSMMRFFRERDRSLNVKSYPFLYYPELYLIEGGYKAFYSAFQELCEPQEYKTMLDKDCSQELSHYRTECKKWNTQSKRSRRGKTLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UR21</accession>
    <name>A0AAV6UR21_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_027077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000313">
        <property type="protein sequence ID" value="KAG8186083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UR21"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12510">
        <property type="entry name" value="RRM1_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="560"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="691"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="1107"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="783"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="827"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="864"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="958"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="986"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1038"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1064"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8186083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1183" mass="132699" checksum="BBE790DBCFB9E0CA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTG9</accession>
    <name>A0AAV6UTG9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin complexes subunit BAP18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000270">
        <property type="protein sequence ID" value="KAG8187499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTG9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397:SF2">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16563" checksum="7F104C006685EAFD" modified="2024-11-27" version="1">MSHSNSSKVGEIFTAAGAAFNKLGELIMTLNSVGESSPSSGKWTAQEMDMLKSSVKTFGTDLERINESVKSRSITQIKAIPIKRKSFEDPSVGVKKQMTTLSSIKPVPQDKMRSVQPKSADITLNMLNAMEPEVDVDGLTSTTKLEYDSSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUF2</accession>
    <name>A0AAV6UUF2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_001663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FARP (FMRFamide related peptide) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000256">
        <property type="protein sequence ID" value="KAG8187900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUF2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002544">
        <property type="entry name" value="FMRFamid-related_peptide-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01581">
        <property type="entry name" value="FARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0027">Amidation</keyword>
    <keyword evidence="5" id="KW-0527">Neuropeptide</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
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        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8187900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="179" mass="20614" checksum="F475724AD8753670" modified="2024-11-27" version="1">MGVALHLISLLACLQTVRLYPMSADRNSLYENYGMRLAKRPFYSYRDALLSPFGLLDPSKVSQGQRKKAVDSTFIRFGRSSPDHPGRNERSIDDIPDPESLSQIPRESMEEDFKTGPQRFLLDHNGCRVRDSTELMRALMSDPKCIRAFQKAKKENVNDTFIRFGKREAPPEREFEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUX7</accession>
    <name>A0AAV6UUX7_9ARAC</name>
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        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_012106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000244">
        <property type="protein sequence ID" value="KAG8188272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
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    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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            <end position="451"/>
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="1316"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8188272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1415" mass="160149" checksum="9E1E2A2B069B02FF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVU6</accession>
    <name>A0AAV6UVU6_9ARAC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000256">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVU6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043608180" evidence="1">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="9461" checksum="104FA2287B43951C" modified="2024-11-27" version="1">MRTKYYMTRSFRRSPMMLRISIILLFFAVFAIAEDCAKKPPCQEKGCGFPMCPKGQEETFDERICCCPFCKDKGSADDKKAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWF7</accession>
    <name>A0AAV6UWF7_9ARAC</name>
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        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat protein 37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_001215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
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        <lineage>
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            <taxon>Araneomorphae</taxon>
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            <taxon>Araneoidea</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
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                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000258">
        <property type="protein sequence ID" value="KAG8187841.1"/>
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    <dbReference type="GO" id="GO:0055087">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006401">
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="6"/>
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        <property type="entry name" value="Ski3/TTC37"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
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        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
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    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="445"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="550"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="584"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="845"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="965"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8187841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1488" mass="168034" checksum="7EA7688DC7A0C838" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UY44</accession>
    <name>A0AAV6UY44_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_013774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000219">
        <property type="protein sequence ID" value="KAG8189246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UY44"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000120">
        <property type="term" value="C:RNA polymerase I transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039495">
        <property type="entry name" value="TAF1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14929">
        <property type="entry name" value="TAF1_subA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8189246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="745" mass="85604" checksum="358304CCB59020AB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZJ3</accession>
    <name>A0AAV6UZJ3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_028661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000221">
        <property type="protein sequence ID" value="KAG8189122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZJ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052143">
        <property type="entry name" value="Mitoribosomal_bL36m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46909">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46909:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL36M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8189122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="111" mass="13494" checksum="EBFA87B635BB255B" modified="2024-11-27" version="1">MQHIKLIRNFIRTTITTTRSYCLTTNLNKLLRSRQCEAMCTPTHLLPDLVPTRGFKDKDVLTKRCKDCYFTKQDGRWYVLCHTHPRHKQRQRWNEKDHWIITHETHGKKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZK1</accession>
    <name>A0AAV6UZK1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000221">
        <property type="protein sequence ID" value="KAG8189114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZK1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8396" checksum="E35C3D17660CBA13" modified="2024-11-27" version="1">MGINFYERKNSTTKFPQLVEQMKPRSGCSKKCLFVDTGGCEGAGVIKWRPLLAMALCQGLPAYQIFIDCDMEGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V058</accession>
    <name>A0AAV6V058_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000217">
        <property type="protein sequence ID" value="KAG8189343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V058"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043406286" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10673" checksum="82B5D40CA27D8D90" modified="2024-11-27" version="1">MSLSLPGLTLVLSVAVCKCRPRRGLGQALRGHQLANTKSLVTLWTREGVKILTTCYFWTRNTQWAGESMAGYGDCIRRAERKGIGWCVLSRRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0G7</accession>
    <name>A0AAV6V0G7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_014530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000223">
        <property type="protein sequence ID" value="KAG8189016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0G7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039545">
        <property type="entry name" value="PGAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892">
        <property type="entry name" value="FGF RECEPTOR ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892:SF17">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043899547" description="CWH43-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8189016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="235" mass="27178" checksum="C93B40AE94CCB4B0" modified="2024-11-27" version="1">MVFCFITSMIFSFEFVNTTICPVFNFCPSVSAITGISPQRYVWRISVALHSTPRLLLASVYYSHYLRKSKNVEDESKSFYKNIVKMNYWFHVTEIMALIGVTYISNKENYPVHEKIFIIFMAASISYMLSTCILSGLNKSPTPTNLENLSYRTKLFLCVIIALTSLGMMYFFYKHRVYCEELAFSWFALCEYVICFANMAFHATIIWDMPAEEIVICLPLSHSSPNCQGMIKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0S6</accession>
    <name>A0AAV6V0S6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Glutathione S-transferase 3, mitochondrial</fullName>
            <ecNumber evidence="16">4.4.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Glutathione peroxidase MGST3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">LTC4 synthase MGST3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">JTE90_011908</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:48620"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57450"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:90632"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:48621"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione</text>
            <dbReference type="Rhea" id="RHEA:75963"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:85236"/>
            <dbReference type="ChEBI" id="CHEBI:194498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:75964"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>leukotriene C4 = leukotriene A4 + glutathione</text>
            <dbReference type="Rhea" id="RHEA:17617"/>
            <dbReference type="ChEBI" id="CHEBI:57463"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="EC" id="4.4.1.20"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:17619"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Lipid metabolism; arachidonate metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Lipid metabolism; leukotriene C4 biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPEG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.20" evidence="16"/>
    <dbReference type="EMBL" id="JAFNEN010000191">
        <property type="protein sequence ID" value="KAG8190184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0S6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004464">
        <property type="term" value="F:leukotriene-C4 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006691">
        <property type="term" value="P:leukotriene metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000004">
        <property type="entry name" value="Microsomal glutathione S-transferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAG8190184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="194" mass="21969" checksum="14C938A1460E6B16" modified="2024-11-27" version="1">MGFSNGPKPLVWSSNTCNDRQKLISFTVHCVFLESSKLESVSFLNFTTKDEDGTMALTLAVDEDYGYVVVVGVLSMLFSYGLGANVFFARKRFGIKYPIMYSDTNNQFNCMQRVHANYLEMFPTFLVLLFCGGLAHPFYCAIAGFVYLLGRLVYSIGYSTGDPDKRLFGLFGYFGLVFLLYSTIELALRLLRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V332</accession>
    <name>A0AAV6V332_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Alpha-mannosidase</fullName>
            <ecNumber evidence="11">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_012589</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JAFNEN010000187">
        <property type="protein sequence ID" value="KAG8190301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V332"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10810">
        <property type="entry name" value="GH38N_AMII_LAM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000002">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000003">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000003">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000001">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048534">
        <property type="entry name" value="Man2a1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21260">
        <property type="entry name" value="Laman-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="13">
        <location>
            <begin position="303"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="909"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8190301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="969" mass="111942" checksum="90F682ED7CCD7BD7" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V501</accession>
    <name>A0AAV6V501_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_021162</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000157">
        <property type="protein sequence ID" value="KAG8191557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V501"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000008">
        <property type="entry name" value="RHOMBOID-like protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043540721" description="Peptidase S54 rhomboid domain-containing protein" evidence="10">
        <location>
            <begin position="26"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="11">
        <location>
            <begin position="69"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8191557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="354" mass="39442" checksum="95D7D737DD695700" modified="2024-11-27" version="1">MNPGRRRQPGMGLMLLFYQLFGVIGIDKIPPVTLGTIGLQVAVFLRLFKLPWYKPTQVCVSAYKVWTKKEYSRLIFAAVEHGDDWHLYYNMLSFAVKGQSLERRFGSFKFAYIIAVFTVLTNVVLVALNTIASDYLDLDFADHCAVGFSGVIFALKVLTTYYDSSYTHQIMGIPIMMPAKYAVWVELVLIQLFVPNASFTGHLAGILVGMAFVKGPLKYFMDLLYSLVKGIVFPSRPTSQFRPQAGPSGYANDRRSRSSTSYASARESYTEYVPPGMTEEEQLRRAMEESMREGANSQGNAPPYPTSYSGSPPPPAGFIFGDGPSFSSAPPQPGFAPDIEELRNRRETRFAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V581</accession>
    <name>A0AAV6V581_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000163">
        <property type="protein sequence ID" value="KAG8191228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V581"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="107" mass="12360" checksum="B9356FF403629614" modified="2024-11-27" version="1">MPQDVFETYLLSGNRWVSGCESLLISEAHSGVLGLPCSDLQVASKDRIDNSPIYSTESHFNILDVYVFCPVQGYLDGLKRRHRVTYSRTFFLFKRVMWYSQNDEINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7H2</accession>
    <name>A0AAV6V7H2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TBC1 domain family member 2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_016460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000154">
        <property type="protein sequence ID" value="KAG8191673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7H2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="497"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8191673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="80481" checksum="10AA5B9EB89CA021" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8J6</accession>
    <name>A0AAV6V8J6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_014103</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000142">
        <property type="protein sequence ID" value="KAG8192245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8J6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15873">
        <property type="entry name" value="R-SNARE_STXBP5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000521">
        <property type="entry name" value="syntaxin-binding protein 5-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000664">
        <property type="entry name" value="Lethal2_giant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013577">
        <property type="entry name" value="LLGL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08366">
        <property type="entry name" value="LLGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00962">
        <property type="entry name" value="LETHAL2GIANT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="1054"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="557"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="671"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="849"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="849"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8192245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1119" mass="124144" checksum="95E7CFEFEFB722A4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V964</accession>
    <name>A0AAV6V964_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000139">
        <property type="protein sequence ID" value="KAG8192403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V964"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="558" mass="64180" checksum="6AD7784F8DDB97D5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCP9</accession>
    <name>A0AAV6VCP9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_011053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000103">
        <property type="protein sequence ID" value="KAG8194444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCP9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF24">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="144"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8194444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="483" mass="54815" checksum="B32A53ACA573C229" modified="2024-11-27" version="1">MCSIPGVAEEDVWLADSGASAHMTRHKEYFSSFESFTPPKEVQVGNNSTILAYGQGVIDVKMKIGGQWIKNYLTNVWYVPEKWQLKFMLHLVKKVHRCGMKDFAIKTRACSEDSEKVWCKLNITDELCAGCLYGKHSRSSFGTRQNRPTVAGGLIHADVCGPMQESSIGGARYFLCFKDDYSKFRRVFFLEHKNEVSNYLQVFLKEFSNAGITVKELLTDGGTEFKNSEVQKILESWGITHRVSMPYSPEQNGYAERENRTIVECSRSLIHSKELPPRTGPTTVEGKAPVELWFGKEITAIDHLRIFGTDCFVHVPKQRRKKWDKKSTEGLFVGYCGDKDGYRVWIPSQNKVILSRDVVFRKEQPLEKIVLLSVQQVTNNGSSHEGTSVSTDVLQDADETEEEESPESVVSKPQEEDETEEDESSEPVVSKRKVKLPEYLKDFVLLAACDVPDSYHSAMSSDDAENWSYFKQPINDKTVDYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCR4</accession>
    <name>A0AAV6VCR4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_005105</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JAFNEN010000121">
        <property type="protein sequence ID" value="KAG8193458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCR4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8193458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="279" mass="33120" checksum="E1493C92DBFE2BC3" modified="2024-11-27" version="1">MRFEYGWYEIDIGIGIYKQTSSASMIFDSLHNYVFGVDDIEKKIQFGHPYAPYCIVSFYIIFCKWIGPALMVDRKPFELKNVLIFYNFFQMIVNTYLTIKAVEGLLRMWNVRCEEYTTSPEMAVVVKDFDLALWHLYLIKYIDLFDAVFFVLRKKEKQITFLHLFHHAVLCLICYIYLESLDIAFYLIVALAINIFIHVIMYLYYFLSAFGPHMQKYLWWKRYLTTLQMIQFGIILMYMAVSFGTGCHKTGPMEISFFCFIAALLALFTNFYTKSFVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDA1</accession>
    <name>A0AAV6VDA1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_013264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDA1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8194512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="727" mass="81272" checksum="124B9B8FDCEF9EBB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDE2</accession>
    <name>A0AAV6VDE2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box/LRR-repeat protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000100">
        <property type="protein sequence ID" value="KAG8194689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDE2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22127">
        <property type="entry name" value="F-box_FBXL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000144">
        <property type="entry name" value="F-box and leucine-rich repeat protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF193">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="58205" checksum="C7D5536566514C34" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDF0</accession>
    <name>A0AAV6VDF0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_003122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000101">
        <property type="protein sequence ID" value="KAG8194650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDF0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18507">
        <property type="entry name" value="BACK_GPRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18294">
        <property type="entry name" value="BTB_POZ_BTBD19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF46">
        <property type="entry name" value="SERINE-ENRICHED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="57"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8194650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="418" mass="45938" checksum="FD02B22F701776E0" modified="2024-11-27" version="1">MAEGGGGSSGGAGTSTAAEAGDAEEEEAERRSDASLFENKTGLAEDMKFLASMPELCDVTFLVGDTREPVCAVKAVLAARSRVFHKILYGQQQQTPSKETLAKKRESTKETKLKMFLKRSSEPILNIPLVQAPAGGHQTMIVEEFEPDVFRQLIEYIHTGCVTLQARTLLGLMNAADYYGLDELRKACMGFVQACISVDTVCALLASAEKYIQYKCTKSLVQKVLEFVDSHGDDVLSLGSFALLPEHVVRLILSREELQADELTKFQAAAHWSRRFCDSEPSADLRETMANFLECIEFYKIPAGVMMREVHPLGVVPDHVIMNALAYQADPSSVDFRKVGSPNRFRRMSLMTTLPSHEASSLLAEKVPASIPEGETTSSPSSTADESTSTPESVKKTSKFSKSTRIRLYRRSKTLAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VED7</accession>
    <name>A0AAV6VED7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000103">
        <property type="protein sequence ID" value="KAG8194423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VED7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="101" mass="11731" checksum="D12DC5AC01123079" modified="2024-11-27" version="1">MKFLEFFKLSFRMRVRSWLTGAMVCVMFVHSVSYEDKQTPDLGLPFAGSVSYSVILSALSGLRRTRKRTAMGMDLTDYLWNKAHEKSRAMVLQRMMKNGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFC2</accession>
    <name>A0AAV6VFC2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000103">
        <property type="protein sequence ID" value="KAG8194416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFC2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="82" mass="8864" checksum="7D42084AFE431408" modified="2024-11-27" version="1">MHDPRLPLRLRNFGHPGSPAYLVGRPADDRAFGAALTTGQLPVTVIEEAAEKRTAPIKFISSGLKQIPAPNDYENPSEVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGR8</accession>
    <name>A0AAV6VGR8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_023329</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAFNEN010000092">
        <property type="protein sequence ID" value="KAG8195152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGR8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000004">
        <property type="entry name" value="Glycoprotein 3-alpha-L-fucosyltransferase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="147"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="284"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8195152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="477" mass="55411" checksum="8C59893FB47F7D68" modified="2024-11-27" version="1">MQSKKVKRIFLLILLLGLLYNLFVTSTHQWRAHLRKNTIQNTPTTEVVNTSTVSATHGALPPHFKGKKLAFDPVYEPRQIGFLPKLKRRHQQQISTVEAVNTSEVFATHAILPPHFKGKKLTFDRVYEPRQVGFLPELKPVPTNYPTKTILLWTKWNSLRKTINYYFLQPGNRSFVKHNCPNPHCRTTFNRKYIHRVDAVLFHLIDTKTEDIPSFRSPRQVWILYNMEPPWQVQKHKSSELNSLNNLFNWTMGYGGNSDIVARYGFVGKSNAVVSSGELDNVFTEKTKDVVWFVSDCSTDSRREDYVEELRKFIDIDIFGKCGHCKCYPSQSSSCYEGVLQSYKFYLSFENAICKDYVTEKFFNVFNYNIVPVVFGGANYSNLAPKGSFVDATKYPQPKLLAEVLIEIANNETIYTEYLTKKFSFRAYLDPWMCKLCNKLHSYKENSTLKDVSKWLDQDSQCNKWNISSQTFIYKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIC9</accession>
    <name>A0AAV6VIC9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Patronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_008529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The CKK domain binds microtubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CAMSAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000077">
        <property type="protein sequence ID" value="KAG8195833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036449">
        <property type="term" value="C:microtubule minus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030507">
        <property type="term" value="F:spectrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.360:FF:000002">
        <property type="entry name" value="Patronin, isoform M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.360">
        <property type="entry name" value="CKK domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032940">
        <property type="entry name" value="CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031372">
        <property type="entry name" value="CAMSAP_CC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058042">
        <property type="entry name" value="CAMSAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022613">
        <property type="entry name" value="CH_CAMSAP_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014797">
        <property type="entry name" value="CKK_CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038209">
        <property type="entry name" value="CKK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595">
        <property type="entry name" value="PATRONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595:SF0">
        <property type="entry name" value="PATRONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17095">
        <property type="entry name" value="CAMSAP_CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11971">
        <property type="entry name" value="CAMSAP_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08683">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25532">
        <property type="entry name" value="CH_CAMSAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01051">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="PRC-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51508">
        <property type="entry name" value="CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="587"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="CKK" evidence="9">
        <location>
            <begin position="1656"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="902"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="948"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1006"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1039"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1289"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1461"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1597"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="958"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1010"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1039"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1597"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1633"/>
            <end position="1648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8195833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1792" mass="203211" checksum="1E16A33F371AC2D3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIR7</accession>
    <name>A0AAV6VIR7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Wingless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000084">
        <property type="protein sequence ID" value="KAG8195588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIR7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7864" checksum="4CAC0527ED4A9AEA" modified="2024-11-27" version="1">MPWTTTLPSAVDGFVDENAPRDHRHRGHAGQEAARTRRHGRRHGEHGFSNRVVNGSLGKMMDNGTRIFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJB5</accession>
    <name>A0AAV6VJB5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TWiK family of potassium channels protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_014146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000067">
        <property type="protein sequence ID" value="KAG8196585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJB5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF352">
        <property type="entry name" value="BCDNA.GH04802-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8196585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35308" checksum="3F3AD91E22FE23EB" modified="2024-11-27" version="1">MLLNGKSLQRHPNRWRCATIPPYHHPFSPGIFPASADPAVESAESSLSPSSLSEEKDLFQRVYLFILFGAHPHSVYILVVEDSGEDFSCGGILCLSESGDLCFVLVWWYRREISFSSNDTASSVADYECECWRADPALAAGANALSTPPPPCVLEMTLEPPQTTKKKKPPKPPKRKTKPLKQASSRKTTTGRCRRCCGRFAAFLFSHVGLCALVVGYSVAGAFAFRALEAPFEEKKASQVSNLRLDTVKRLWEITDKLNVLYKDNWTELVEAEVRRFQRDLVVAVKEGYDGKEGRGQQWSFSGAFLYSLTVITTIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKS9</accession>
    <name>A0AAV6VKS9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L46, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_004346</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000059">
        <property type="protein sequence ID" value="KAG8197080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKS9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000018">
        <property type="entry name" value="39S ribosomal protein L46, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="10">
        <location>
            <begin position="38"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8197080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="299" mass="34864" checksum="38A9A39DC4BD83AE" modified="2024-11-27" version="1">MKLKSCATLFFRTNSILKGNAYKHNSVLIAASRTFSNWHIVGALCLERKPVITQPLTPLEKKYYDYMQKLEVEQSLLSDHEKRHLEDKKINEKLKKGELEDMDSIAKQTAQDFEDLRQEQFNKYKPNERESEDDKTDNKQSLRRKLDSSLVLVIKQKLGNDHRWVLPQTIHQNGETLKQTAERVLKEICPNPPKIRIMGNAPVGYYKYKYPKVAREDGVFGAKVFFFRGQLLEKNVKFLDINQTDSLWLTHNELNEVLQKDYGKAVQSFLFPDFIDVDNTDYSLYSSEDENDMKTTASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNB8</accession>
    <name>A0AAV6VNB8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000043">
        <property type="protein sequence ID" value="KAG8198164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNB8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="11081" checksum="5C5F05684546692D" modified="2024-11-27" version="1">MNSTVRFLVHQSPPLVPFPPIVYPIVPVSFFPKVPLPFRNRNQHVCGLFPAEARRKCPSAHAPEVPRVITHPQSLLKKTATHALPRIPQETYCFFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNJ5</accession>
    <name>A0AAV6VNJ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ciliary microtubule inner protein 2A-C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_001589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CIMIP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNJ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018902">
        <property type="entry name" value="CMI2A-C-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22146">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22146:SF8">
        <property type="entry name" value="PROTEIN FAM166B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10629">
        <property type="entry name" value="CMI2B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary microtubule inner protein 2A-C-like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8197660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="300" mass="34489" checksum="4FF2945B7F50C2AE" modified="2024-11-27" version="1">MRDYQYYIPGYTGFCPMLPYHIGESYGKATRQILRERPQDLLKDRLSKVRSRKFQRSSGDHASGYPNSYKENDRCRCGCGCVRCRCVNDSGDQCVGRHYKDSNAGRRWEKNESMKKTREPPDSCQPAYILVEAYAKSDCSSHKEHRPRKPSPPPPEKPKQVPVVLAQHCHHPLFIAAPCQPVIADPYCPRREESCCSSQPSNYRQQSSKQSRKGSCCDSSVRSHRQKVSDRKCCGESDNRTWTQGQTRKAHPFRECGVIPKYTGHITGIHFAIGESYGPSANRLLRKHHDKMKEKNIYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNV4</accession>
    <name>A0AAV6VNV4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNV4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10513" checksum="CCE02E4A3EF29963" modified="2024-11-27" version="1">MIRLAIEERKEGIVGRLLNCRDKRPRIASLFGAAGLYYKSNRPCMTTPPRFAQGQNCVATDGWTSLGGVTERRNRKIKWTTIGKEQRKNVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP48</accession>
    <name>A0AAV6VP48_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate-semialdehyde dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="3">1.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD(+)-dependent succinic semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_001878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000045">
        <property type="protein sequence ID" value="KAG8198043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP48"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="37"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8198043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="480" mass="52594" checksum="95D870DD191CAC36" modified="2024-11-27" version="1">MFLFRTVKFRSSSFLTTYKMCSHFSFSKNKTFINGKWVSAKDGKEFPVYNPADGSIVANVPDCTVSELNEAIEGSYDAFKTWKNTTAKERSAILRRLFDLQMKYKDDLARILTLEAGKSLAESVGEISYGASFFEWFSEEARRIYGDIVPSPVKSRQMFFYKQPVGVAGIITPWNFPNAMITRKVGAALAAGCTCVIKPAEDTPLSALAIAQLAEEAKVPPGVINVVTSSRNNTPAIGKGMCEHLKVATISFTGSTAVGKLLLEHSAPFVKRVSLELGGNAPFIVFNSANVSKAVAGAMASKFRNSGQTCVCTNRILVQEDVYDEFCKELTKVMQNQLVVGNGMDSNVTVGPLINENAVKKVNSHVEDALQKGAKLILGGKPHSTGKTFFEPTLLTDIKQNMLICKEETFGPVAGVMKFKSEEEAIEIANSTRSGLAGYFYSEDVSQIWRVAQALEVGMDLIKLNSRIYLNPKGFHVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQD6</accession>
    <name>A0AAV6VQD6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tesmin/TSO1-like CXC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_020901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000044">
        <property type="protein sequence ID" value="KAG8198069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tesmin/TSO1-like CXC" evidence="2">
        <location>
            <begin position="1325"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8198069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1668" mass="186526" checksum="6EE884F013E0B882" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRF9</accession>
    <name>A0AAV6VRF9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000036">
        <property type="protein sequence ID" value="KAG8198755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRF9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="40"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="140"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8198755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="354" mass="39374" checksum="061D11A1D19C2F3A" modified="2024-11-27" version="1">MAPWLCESGLYATSECWLYCQKLAWNSTTLSNIQEFVEQTIVLKKDKKNELGISIAGGSDSYLEQICVMEVHRDGIAYSDGRLRKGDVILAVNDNSFREASLGDAARCLREAPSTVRLIILRENPQALFTSHETPTKFLTVELRKFSIKDSIGISIMQRTNGRGVFVTYVQPGSVAARHGRRISQGDQILEINGQNVRESNQKDVAHIIQNLDGALVLLLGRVPSLHASVQEWVKWKAQQCLRTRTSTWSSYTANSKEKLQIQRPSLPVSKESPALGFANSIAAMICSTVVPDLTRNMMAAPAPSKSPCASPHSSMRRSRLSIPDERGRHQDIKPQDFKQDKPPRVPSILVTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRG9</accession>
    <name>A0AAV6VRG9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_016038</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000030">
        <property type="protein sequence ID" value="KAG8199219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRG9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8199219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="303" mass="34116" checksum="8B75451DC8098696" modified="2024-11-27" version="1">MEWPKVQVSSTKAHTEYKFIGASWYPITMAGAMFATISLPYLIVLARGTLYPFLPFISQVSGSPPMSGIFNLLLIVSSLFAFIGLNLLHMGIRIQKKRLEDDWVRQTASLLNKISLIPGHVGIMGMLIVGSYPIDFYRRTEIWMGVTIIPHLIGALSLFLGGMFYCILITYIMSLLHPEQKQILGIRIFLVSLITMCSALQGYTVREGFMNELVGESIKTCIVEADHLPYNLHYLISSVCEWCLVLAFIVFFTTLKEEARDFCFTMCITIKEDAQEKVTEKKTETVKDVNHNTGASDKTSDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRK9</accession>
    <name>A0AAV6VRK9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000030">
        <property type="protein sequence ID" value="KAG8199135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRK9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7617" checksum="B21DBD83D0463818" modified="2024-11-27" version="1">MTIPSKRHFPSRMHDMCRDLCTEVNARNPSLARSILSAPTASVLLHQVPLQGCFDLTLTNLFFQVSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSR1</accession>
    <name>A0AAV6VSR1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000036">
        <property type="protein sequence ID" value="KAG8198714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSR1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="9052" checksum="3AB14AFB3EC2F407" modified="2024-11-27" version="1" fragment="single">RWLAYVVDPESYGGGSLATGRVTHAGQVGGETQDQEEHPGPPGWRGKPTYDVRTELRPLYNLSLIDHVLNPSVKALKRGTKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUZ2</accession>
    <name>A0AAV6VUZ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Negative elongation factor E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_009428</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM NELF-E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUZ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033102">
        <property type="entry name" value="NELFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17250">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17250:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="118"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="211"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8199591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="315" mass="35979" checksum="5A45124EF2DF1D9A" modified="2024-11-27" version="1">MHLVQLPKELSKEEKELQAKYDVLRNLKLKQKLYEIRGSSKHQNSYNVSNDAVQICLKKNAVKVLEKSKREKFREIEINKMQKTCGFKRSLKSNGVNQIVQKKCAMAEFSPKTIPRPRSVTIRGQNLTEKQLLDHFHKFGPINKIRLGSENASAVVTYKTPEDAIRASDDKPLVESVKMHVELAKKTNPLWINIATEEAIKIDSIIHGCNSTVYVSYQGRLTDQDFKYIFGSVGTVQKIYIPKVKTNQFAFIRFEFNIEAERAVNEVNGLVYKGITLSVSLRKESSKDSNVLVETTENVPDVDPRELIIYDCLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYE4</accession>
    <name>A0AAV6VYE4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">28S ribosomal protein S18a, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_012741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYE4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF66">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8201675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16454" checksum="5245578F80EB6CB4" modified="2024-11-27" version="1">MNYTKFMCPVLFAIRQNVRQLSISSVKFLREVRVTETEKQIVIEGVEVKSEREGKVVDMAKRGGCPLCRLGLKNLKHSDILILQQFINSDGTVIPQHITGICNKQQFRVKRAVGLAQRAGLIPKKPGTPLFGDWEKYNTYFKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYT3</accession>
    <name>A0AAV6VYT3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000007">
        <property type="protein sequence ID" value="KAG8201218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYT3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9008" checksum="ADFFF36123CD79BF" modified="2024-11-27" version="1">MSCLLSPPLEPSLFAPENPCNKKQMVAALGPGKNGSVPEFVKKGITTYYALNASPVNVARFGRRWDVSPKCPGKDAKLSSSNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZ86</accession>
    <name>A0AAV6VZ86_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000009">
        <property type="protein sequence ID" value="KAG8201033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZ86"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="10355" checksum="AE08139C7B6654B9" modified="2024-11-27" version="1">MIAVIGCIQLRMNMSNRKDEPLFPCKRAKVVYSRSKIFFLSSSKLSKYLRILAKKLKLLYHTSSNHNRREALSHPFITCTDILSKMHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W561</accession>
    <name>A0AAV6W561_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W561"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.60">
        <property type="entry name" value="Spidroin, repetitive domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043070">
        <property type="entry name" value="Spidroin_repeat"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8202068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="660" mass="74842" checksum="09B5AF76F9BF8A11" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCS0</accession>
    <name>A0AAV6TCS0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007168">
        <property type="protein sequence ID" value="KAG8155694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCS0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="160" mass="17585" checksum="E842B0E105C7165F" modified="2024-11-27" version="1">MSRTTNSRQSPGMRESRINRRFSRNGVDVEARTGLNQHSITPFLPGRQETHEGAQRQLARGIILAHCPQFSPTSSVLRTKSSAAGCAVCSSQIWVGAFIPKEFDVCWWPSEGPFRIGGEEFTPKGFGFEDEESVGEGSDCVGVPGLSRSVDGCDQPYFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TD41</accession>
    <name>A0AAV6TD41_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006540">
        <property type="protein sequence ID" value="KAG8155846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TD41"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="189" mass="22105" checksum="A50E6E81B76C860F" modified="2024-11-27" version="1">MVVGKKYRSYYVLVNFHEEKQFSVLRLKDAVPDCLNFSDSYDINKWDRSTEVETKWENETYPAYFIQFGENKRMMDDLIDQIVVSGDTSNLPLLQTENEGKRQKKRKRAEMAGPKMQKTNSSLHILTEVKEKIAAHKENRLEKAAEQLAPGDDVIRAELLMTKELYSQLQVKYAELKKNIKPRKENSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDL3</accession>
    <name>A0AAV6TDL3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007276">
        <property type="protein sequence ID" value="KAG8155682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDL3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="171" mass="18224" checksum="3E19640778CA5516" modified="2024-11-27" version="1">MGHEGRRGGHAFLSAVSRRVASVGLGCAGSATNTRDKRGQRRVDVVGGSSFSTLSGSGGEYMKEVAKSGSRLQIKVFSSIPMSKVPNDMDSLKEALNKFPDDLANFNKGGGIPIRMELWPLSLLDKSLPEKIRKTGDGSLDMTKSPDQSSQQRGYGSPIPGGVQEVLTRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDZ3</accession>
    <name>A0AAV6TDZ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006471">
        <property type="protein sequence ID" value="KAG8155912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDZ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="270" mass="29372" checksum="74426DB88A1D0692" modified="2024-11-27" version="1">MVASHHWPLAQRAHEPSVRTCGSSRTEQVYYRNDESSVEAVHLGDLLADNGYGPARDKYTISLGFSRGQQQGAPDTAEEAVLLREQSPYPGRPIPGTRTLTKKKITLHRVLRRRLRVSVALPHLVRRNYLQVRVGNINTDSLSVVQAEDKHEACVCVSPPGRRLASERSSSDPLDRPTPCFNLLFNGTPSPVFSSFQGSHLSICYYHQEFGPPVAAPGGHHAGNFNARHRDPPTHCGENSTREALPSSGPVGIGPTAGALIISAASCFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEG4</accession>
    <name>A0AAV6TEG4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_026243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006154">
        <property type="protein sequence ID" value="KAG8156231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEG4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF50">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="132"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8156231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="220" mass="24385" checksum="D4830CBE90FF394D" modified="2024-11-27" version="1" fragment="single">ERRNLQGRRLEKTKSLGSDNDQVLLTNELNKIAKLQVGVVQAKESNNEKNEQLQNRKGGNMPDLISRIIPDDKSDLIILEQNNKVLKSAKSEEDELSKDNFSSNKEESEKDGQPDSPKRHSWFFGTHKNSLVFPVIVSRNPELGFSIEGGIGTPRNPSKPYDNGIYVAHVLDEGPASSLLKPGDKILQVDGKDFTQLDHNKAVAALQEGGTTISLMVSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGJ9</accession>
    <name>A0AAV6TGJ9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004660">
        <property type="protein sequence ID" value="KAG8170933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGJ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="55" mass="6322" checksum="86E8B14D5F0E39F7" modified="2024-11-27" version="1" fragment="single">KRHHRLSEFLPWGPGKIKGHRQEEEPEKFSRVFDKDGNGFISAAPTAPRIQPGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THH6</accession>
    <name>A0AAV6THH6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004385">
        <property type="protein sequence ID" value="KAG8171130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THH6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="149" mass="15945" checksum="DC6BDEFFD3BA6F9D" modified="2024-11-27" version="1">MGLICLRRNPDLTSICRQNPYGASPGFLWPLLSGDSSPSFGSQRVRSNSPTSQNGTGGPPGGPPAPEGKGIRMRPTPRRPVFHFAPGVIQDPLLAPFDSLVRVSRRGGPGQGTCCRVRLGTLTPNAHISPRPLRAVDSALGFSLFTRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJ97</accession>
    <name>A0AAV6TJ97_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Senescence-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003202</name>
        <name evidence="2" type="ORF">JTE90_009669</name>
        <name evidence="4" type="ORF">JTE90_012666</name>
        <name evidence="3" type="ORF">JTE90_022080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006572">
        <property type="protein sequence ID" value="KAG8155805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010004770">
        <property type="protein sequence ID" value="KAG8170849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010003964">
        <property type="protein sequence ID" value="KAG8171449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010003585">
        <property type="protein sequence ID" value="KAG8171756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJ97"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8155805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8171449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8171756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9239" checksum="66D833BC127780E4" modified="2024-11-27" version="1">MIGRADIEGSKSNVAMNAWLPRASYPCGNSSDTSCIKLVKSKGSIGLLSQSVFILKIKIKRAFALLLYARFLSSLSSPWDICVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKA8</accession>
    <name>A0AAV6TKA8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_027641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003039">
        <property type="protein sequence ID" value="KAG8172153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKA8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043428648" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8172153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="145" mass="15818" checksum="9C132CEA403F7D6F" modified="2024-11-27" version="1">MKWALVLALVLCCGSTRGETENDSIESLDKLTEQLEQELLFRPRTLLANKHKCGEIECQNGAIECTGDGKCQCPKGYTGDDCSQVGTCDLKNDNCKNGGKCEDQDGQTFCTCAKGLTGDLCEFFTPVSVTNLETSLVEYENRVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKZ7</accession>
    <name>A0AAV6TKZ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_002509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002786">
        <property type="protein sequence ID" value="KAG8172373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKZ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="173"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8172373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="839" mass="93314" checksum="E16C41A2909FC75C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TML2</accession>
    <name>A0AAV6TML2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_002690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002345">
        <property type="protein sequence ID" value="KAG8172814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TML2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8172814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="109" mass="12248" checksum="6904BC243D171D11" modified="2024-11-27" version="1">MDVPLQKGNFRGPLARGFVDIPWRMRKPCKKPGSRWTSVPGGIYNEPQCSSEQLDHGVLVVGYGTENGKDFWLVKNSWDTTWGDKGYIKMARNQDNQCGIATQASYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNB6</accession>
    <name>A0AAV6TNB6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001721">
        <property type="protein sequence ID" value="KAG8173472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNB6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8835" checksum="EC99A465B3E20CDF" modified="2024-11-27" version="1">MNRACGRIPAASPSAGTPYALFRRNTTNNLREGMDTGAQVKNPFFTRSQQNAKPRNDGFLPYSFRGYVFENELFVELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TP61</accession>
    <name>A0AAV6TP61_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001704">
        <property type="protein sequence ID" value="KAG8173496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TP61"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="167" mass="18296" checksum="12549ECD82C4E033" modified="2024-11-27" version="1">MNVATIEKAISDFESTGIHPVNRNKFKEEDFVSGLHACEQRTFYYIPSLVVEEPIVAINKQDGYLGLPGPSGMSKTITSETASNSSGKITSVINKFSTLPALAAEQLKGNARRKGQSLILTSTAMKATLEKALEKRKQRFEKIKCCQKGSSKAIGNFYKQVGHRPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPG5</accession>
    <name>A0AAV6TPG5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">sn-1-specific diacylglycerol lipase ABHD11</fullName>
            <ecNumber evidence="3">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha/beta hydrolase domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_027100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48596"/>
            <dbReference type="ChEBI" id="CHEBI:11152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:90605"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77107"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:77129"/>
            <dbReference type="ChEBI" id="CHEBI:186738"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75468"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38503"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:77272"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010001868">
        <property type="protein sequence ID" value="KAG8173341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPG5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8173341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="147" mass="17155" checksum="BD029B8863C396F7" modified="2024-11-27" version="1" fragment="single">MHGFLWNKFVFRNIARDLCNETKRKVYSLDLRNHGESPSREECSFFLMAEDVKRFLDENSLKKVVFVTHSFSSSIAYLIALERPDSVEKMVMIDNPPFNDFNDHFSRESVFPQLEIQNKLLKTLDPKMKLKVAKAKFLNLATFGTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQ50</accession>
    <name>A0AAV6TQ50_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_017928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001371">
        <property type="protein sequence ID" value="KAG8173995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQ50"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8173995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="326" mass="36882" checksum="4034F12B5CE44F21" modified="2024-11-27" version="1">MEDLVIREENSEMVDDVVRPQKVLHDCPKCSRSFANIGHMKCHFYRVHPEFKLTEFVECEPPDTTKVCRLCGAGFETRRELNKHDCPGWEDGSRTQTYLCAHCDRRFNNKTSLQLHCMRQHRKGAKHTCALCQKGFASAPNLAAHMRIHAMRGEDKPEEVFAASEENNGEVPDVKEEVLAPPPSAFQCNVCDEGFKTARSLKSHMSAHHEEAPLPSVRCPTCEDEFGDAAALKEHRLEVHPVEKTFACDVCPTLFATNQALVIHKRVHEPKTSHVCDVCEASFSTKMALATHRKKHSSKEKKFACATCGKKFPLKCHLSRHLKTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQF2</accession>
    <name>A0AAV6TQF2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001314">
        <property type="protein sequence ID" value="KAG8174115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQF2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="126" mass="14225" checksum="F18780469BC5E211" modified="2024-11-27" version="1">MVAGSKIGFWGKGVSRTTLTKVLGNPQQGPSSKRLREKPTPKTGHSPPLGKTHGFFGRHPLKRLAGERKGRPWSWDHKKILGGTKRGNKFNVGLSPPLGKRYWKHTVERDGKTSRRPRLEKREQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQG7</accession>
    <name>A0AAV6TQG7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001462">
        <property type="protein sequence ID" value="KAG8173861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQG7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038602">
        <property type="entry name" value="Mite_allergen_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020234">
        <property type="entry name" value="Mite_allergen_group-7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16984">
        <property type="entry name" value="Grp7_allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="256" mass="28918" checksum="3716874BBECC3281" modified="2024-11-27" version="1">MSLLIFVFHSEDDTLSLPCVSSDVDQYLDEVLARARAELPDPLRLPPRSSVVELSDGLLWGLSNITRLGEAEVSCEGDDIRIKAVITSDEIKGRYTWRKKKPGRDWEGYVVFISNDFQAEVEGVMEKREGGQKSHPRLERFRIKKFKDARVEMTGLGYITWALGEMTTLMSGIFQRAIASAIQGPLKEALERHMRELEIQRLYPEPEPSGLPRLLAVGHPLLPELPQEEARHRESRGAGSLERRQRGHCRLGATGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQY0</accession>
    <name>A0AAV6TQY0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001351">
        <property type="protein sequence ID" value="KAG8174026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQY0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="28"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="165" mass="18667" checksum="57D8BD94579403F2" modified="2024-11-27" version="1">MGRDIAEWCKACLECQKNKIHRHTKSAIGDYPLPSCRFSHINVDVVGPLPTSCGFSYVLTCVDRFSRWPEAFPMVDQTAATIAETFFAGWISRFGVPECISTDQGRSFESDLCHALMKFLGTEKLRTTAYNPASNGLVERFHRQLKQAIRCQAIDKWVQCSNELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSR6</accession>
    <name>A0AAV6TSR6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001164">
        <property type="protein sequence ID" value="KAG8174701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSR6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10483" checksum="468CD821EFEC5191" modified="2024-11-27" version="1">MILSVLEYKSKDYDIVLQDDFINLTKIPRKSVYVAAGLAVKVKKYQKRYYISFSKGGLDTERKKFINVPIAEIGNVQKALTILDKHIKKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTD7</accession>
    <name>A0AAV6TTD7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_020793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001044">
        <property type="protein sequence ID" value="KAG8175260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTD7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8175260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="602" mass="66154" checksum="3871EA97B969774B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTL4</accession>
    <name>A0AAV6TTL4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_014339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001096">
        <property type="protein sequence ID" value="KAG8175004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTL4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF14">
        <property type="entry name" value="RETROTRANSPOSON COPIA-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8175004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="243" mass="28324" checksum="54B72CEA0206DDFB" modified="2024-11-27" version="1">MKFLLIERGLWKLVSGKETTPAAKEELGNYEDRCDRALSTIYLNISEEYKRLIKTETCPIKAWENLKSYFEPDDRVRHQMIFNEFLECKPNKSEGFAMFFSKIKDLVDQLKDIQHPMDDDRVIFHVLRWLPDSFSSLVQNITSWSKTDFTLIKVESAVLAEDARQKLKQQDKGSLSVAYSTEAKGRQSRSVVCYHCGKEGHIARNCRLKSSVSQPRAHLSGVETRRPPWRKNSPWRRSNSNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUV7</accession>
    <name>A0AAV6TUV7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000958">
        <property type="protein sequence ID" value="KAG8175720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUV7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="132" mass="15050" checksum="ADC2E695A1015E1A" modified="2024-11-27" version="1" fragment="single">MTAATVAKSFYNIWIVRYGCPLRITTDQGRQFESELFSAFSRLFGIQRIRTTPYHPQSNGLIENFHRPMKAALKAYDTEEWSDALPTLLLGFRAAFKEDLQATPAEMVYGRALRLPGEFFDPTPADESPKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TV01</accession>
    <name>A0AAV6TV01_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phospholipase A2</fullName>
            <ecNumber evidence="10">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_001817</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phospholipase A2 family. Group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="10"/>
    <dbReference type="EMBL" id="JAFNEN010001000">
        <property type="protein sequence ID" value="KAG8175446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TV01"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00125">
        <property type="entry name" value="PLA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033112">
        <property type="entry name" value="PLA2_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF107">
        <property type="entry name" value="PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00119">
        <property type="entry name" value="PA2_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043088184" description="Phospholipase A2" evidence="10">
        <location>
            <begin position="18"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="11">
        <location>
            <begin position="43"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="84"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="91"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8175446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="179" mass="20197" checksum="DCFFFB0251E44D85" modified="2024-11-27" version="1">MLDKLCLWWIFMEIISALNTTEISLEGVGNESRSLRLPEETRSVFQLGHMIRCQTQCEPLAYRRYGCFCGFKGAGQPVDAIDKCCLDHDWCYARLRCPPFMLYALRYAWICKKPGSVQCTTGNYNVSPVVNQCALRLCECDRQFAKCIGRYSCPQRKAVCWSNPLIAISNILASLGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVB0</accession>
    <name>A0AAV6TVB0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000983">
        <property type="protein sequence ID" value="KAG8175566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVB0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8044" checksum="DFACBB08820CFB43" modified="2024-11-27" version="1">MILQSGYGHMIACRDQAVKTVESPTNFGWREGGGIHAWVVGGKGVREDRIIEFSFGKNCGEVTLDVSRWNMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVG3</accession>
    <name>A0AAV6TVG3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000938">
        <property type="protein sequence ID" value="KAG8175945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVG3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="137" mass="14979" checksum="107944037765F334" modified="2024-11-27" version="1">MSTLRDQVNITFQELKTAIATHFTPCITIAQGISKLTSAIQGPSESVQDFAVRVEGLAKSTNAPADFTTQLIFSQFISGLRQDIKTQIHIQNPRDFTEALQTAIRVEKAFKDITQNVNSLEASAGPQGLTSQTKMHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXQ9</accession>
    <name>A0AAV6TXQ9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_001974</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000848">
        <property type="protein sequence ID" value="KAG8176835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXQ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8176835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="525" mass="57284" checksum="360E16DCD181FE55" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYU9</accession>
    <name>A0AAV6TYU9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_015420</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000837">
        <property type="protein sequence ID" value="KAG8176954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYU9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF403">
        <property type="entry name" value="CYTOCHROME P450 306A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8176954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="56413" checksum="568385CB1B1826D6" modified="2024-11-27" version="1">MDISWITDNGSFSPTTLSVVIATLVAAVAYYIFKNSDLPPGPTGVPFLGFWPFIDNVGFPQQFEKLKNKYGDVFSFTCTGTLYINLGSSKAVREAIITKSDCFSKRSEAFNYMTDIFEGGIFLQHSEEWKANRKFFVTTFKERVSLSVKDLLSGSLYDSVNSTMAELREKAEQTVNIVQVLVSKCNADFRLTLFGENGISEERVTEVNELYEPVIAFFTFPNIVVTGSIARYLILPFTPGYKLASANSKKIEKILYQIIDEHKATFDENHMRDIIDEYIRERIARGRKGDPTAHHFTDKGLMRSLIQFIGDGVFSVAGFISVFIYMLLEHPEEQEKIYRELVEVVGKDRQPTIEDKSRLTYTNAFIQEALRTSDAIASLPVLECTQDTTIRGYRIPKGSVLVLNVHNVHNDPEVYDEPQKFKPSRFVVTEGKRKPEPLLTFGVGKRACIGETFTMTQVFLLVTTLIKTFHISTPADVKNHELELFTEGKLIIVLKPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0M4</accession>
    <name>A0AAV6U0M4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_028305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000771">
        <property type="protein sequence ID" value="KAG8177584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0M4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="274"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8177584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="321" mass="36942" checksum="CB7ED4FB9558B22D" modified="2024-11-27" version="1">MSTSVPSRPDVQDTGCGFTISKQFSLDAFRSALTYNPRPDDLFIVTYPKSGTTWMQIIVACICRRGRPFESALEFFSESPFLEMTGSEGPLAMKRPGAIKTHLPFHLAPWSDEAKYIYVARNPKDVCVSFFNHVKNMNGYNFTDGQFDDYFEIFMEGKVNFGDYFGHLRSWYDHKDDPNVLFVTYEELKTDVKSGILRIAEFMGQEYKVMLESDPQILNDVIEHSSFRYMKENFDRQVAELSATAHETVKRKPELIAGLKVLFSAENKLFGTASDSVSFVRKGVVGDWKNYFSQEQIKRMDEKFREKMKGTDIPNLWKGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1E8</accession>
    <name>A0AAV6U1E8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000763">
        <property type="protein sequence ID" value="KAG8177662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1E8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="112" mass="12866" checksum="8AD54EC18A1D4D8E" modified="2024-11-27" version="1">MGENSHRFCWTDVRVHAYMFLVIVDAHSKWLEVYPMKSTTTFKTIESLRDCFARFGLPVTLVSDNGPQFTSHEFKTFMNSNGIKHTKRLLHSNHQAMDRPNVTCSLSSKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1Z1</accession>
    <name>A0AAV6U1Z1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_025965</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000712">
        <property type="protein sequence ID" value="KAG8178200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1Z1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="2"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8178200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="395" mass="44694" checksum="C759540240AA0B18" modified="2024-11-27" version="1">MKLRVVLPPLKDINGYRNIHKGVASPEAIDIRFLELIAQRMGFSYELMLPVDGQFGFHQPDGNWTGIVGMLQRDEADLSVAHLSMTKHRLQAIDFSESYWAEGPTFMTELPSLLPKTYFYTYPFTLVLWLALLFVMIVTSFFLVPREGFGEVLMTVLRGLCRQSVNVRSAKTVSRKLLLGHWLYFANFVTMSYCAVLLSFLTVPLREKGVETIDDLCQAVEEGSYKALVPMGSSIHQYLLNSEIENLQELGRAILNNRWQYDTREDIENYFDCGTALIGPKMRFTGATFSGRFISKDSFGMWNIGVALNRRFCCKKRLNVLLRRMFAAGLYQKIIEDEGFIAGIGRQNSDTEKHLKGASSVSLSIDDLYGVFAMLVAGYIAAGVALLLELVWNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2N7</accession>
    <name>A0AAV6U2N7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eclosion hormone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000743">
        <property type="protein sequence ID" value="KAG8177849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2N7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008255">
        <property type="term" value="F:ecdysis-triggering hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018990">
        <property type="term" value="P:ecdysis, chitin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006825">
        <property type="entry name" value="Eclosion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04736">
        <property type="entry name" value="Eclosion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043933237" description="Eclosion hormone" evidence="1">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8238" checksum="70BA9C912B425888" modified="2024-11-27" version="1">MISIIILAVVLTLTPNSVFGRNAGLCIHNCAQCKQTFGPFFEGQRCAEWCIRTQGSTLPDCSELDSIADFLTKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3S8</accession>
    <name>A0AAV6U3S8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Neural proliferation differentiation and control protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_023270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000673">
        <property type="protein sequence ID" value="KAG8178724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3S8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009635">
        <property type="entry name" value="NPDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23352:SF2">
        <property type="entry name" value="NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23352">
        <property type="entry name" value="NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN-1 NPDC-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06809">
        <property type="entry name" value="NPDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043933233" description="Neural proliferation differentiation and control protein 1" evidence="3">
        <location>
            <begin position="19"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8178724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37002" checksum="FCFF75A351864FA0" modified="2024-11-27" version="1">MGILWFLVCLSSCGLAYSQETDEAVMFQKDLQDFVRRLTHQPVQQYPTTHQDIVRPQYSRSYPLPRAREILEEQGALVPGDLGYPSTRGRPGGARAYASAYSSVKRPFGDGEVDSQADAVAFSSVKDVNNEESLAENIESVERLSTLSVGPPNLSTQERKSTTDDSDRITGPFTSKQQQVEIKEEDSFNDVYFVAIVAGCCAVGIFGVISAGFCFYRLQKSRKAAADVDYPAYGVTGPCKDVVSPSGDRKLAQSAQMYHYQHQKQQMIAVEKAGSTKNASASDVDSEEENEEGDYTVYECPGLAPTGEMEVKNPLFHDDSTPVSPPVVHKSDNIHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3X7</accession>
    <name>A0AAV6U3X7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000703">
        <property type="protein sequence ID" value="KAG8178299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3X7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="273" mass="31143" checksum="498FAD1F5BF33E6F" modified="2024-11-27" version="1">MGSVNSCFRRIFPCLGRSDNGIDFNGQSDTVRLQRKSTISMNEFPTFEGTFEDYATNDVPTVMEGHVATDQTQRLSSSRSFESPLHQRPLQQNRPSTQRPSEVKLTQQQIEPNKLTRDIWNKLHLLKKTETSPSKSLSKSSAQPFFVENQNVILPGTLVASNTESQNRQVDPWINSPSRVVWKRCFELRRRIHHIEWMPNSSHSPIFGQNEDSNGSDSFAESTEPPIPQEGDRNSDLMPLRPSQLQILQVRNNPSVDFEESKEQTLECIEKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3Z3</accession>
    <name>A0AAV6U3Z3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000665">
        <property type="protein sequence ID" value="KAG8178810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3Z3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043664020" evidence="1">
        <location>
            <begin position="18"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="180" mass="20830" checksum="100FA4455541080A" modified="2024-11-27" version="1">MLVFLMVFLLLFEFCSSKIIENNIESYSSALKETTIKPVESDANRELSSETWETVLETPVNQEDLIPFKAILKNHKQKFKKKDPGNLSPTVVRACNSNAQCQKDECCLQKPWTNHFFCAKRIREGKVCWSRPHNATDTWDKYRIICPCISKHECRFQDPIFVLKPVLAASTCQPKKEEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4B0</accession>
    <name>A0AAV6U4B0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000648">
        <property type="protein sequence ID" value="KAG8179115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4B0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044000634" evidence="1">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="183" mass="20880" checksum="70DBF219A5FE5438" modified="2024-11-27" version="1">MSTLVLLLWIIAGSAAKDFRNETIACVFQKYDACYNYISTLGASFTHRSDMTVQELAHSCKNEADVQNCIMNVAPICRSNPEFGSTQRITSLVHNICTNKSVDQIMFLNSSSCYNQYYYKRDECVKKYDVGKNTDAKSLCCSNLKTLRCLAEDMQSVCPRNYTQFRTNLTETYRGYHTLNLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4V5</accession>
    <name>A0AAV6U4V5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FXNA-like protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_011596</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000636">
        <property type="protein sequence ID" value="KAG8179332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4V5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000008">
        <property type="entry name" value="Endoplasmic reticulum metallopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053973">
        <property type="entry name" value="ERMP1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053974">
        <property type="entry name" value="ERMP1_1-A_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF22">
        <property type="entry name" value="ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22249">
        <property type="entry name" value="ERMP1-TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22248">
        <property type="entry name" value="ERMP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="632"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="16">
        <location>
            <begin position="163"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum metallopeptidase 1/1-A TM" evidence="18">
        <location>
            <begin position="431"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum metallopeptidase 1-like C-terminal" evidence="17">
        <location>
            <begin position="663"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8179332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="891" mass="100357" checksum="BAFF7E36C8ABF0F6" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U547</accession>
    <name>A0AAV6U547_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_023624</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ATG16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000645">
        <property type="protein sequence ID" value="KAG8179162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U547"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="6">
        <location>
            <begin position="10"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="329"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="470"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="500"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="100"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8179162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="533" mass="60139" checksum="D6B8A223B4A26A37" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U690</accession>
    <name>A0AAV6U690_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gastric intrinsic factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_016122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000619">
        <property type="protein sequence ID" value="KAG8179552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U690"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015889">
        <property type="term" value="P:cobalamin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002157">
        <property type="entry name" value="Cbl-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051588">
        <property type="entry name" value="Cobalamin_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559:SF18">
        <property type="entry name" value="TRANSCOBALAMIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559">
        <property type="entry name" value="TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01122">
        <property type="entry name" value="Cobalamin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="168"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8179552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="49586" checksum="A4A13AAAE724B156" modified="2024-11-27" version="1">MEFRSDDNLNYSGFSVEYSFIDIAPPPTIPPTIVTRSPREVLKDEVSLAKKRLVDWFMGLRRKGTQTRKWGHQLPRIAIALYLADQENLQSGNRTMYEMNYELTILLLSKLQGGGHLKRRDLSLYIPALMVACVDPRNFHGRDLVAELRSDIESNNGTGSPFELLVLCNAGDAMSDRDVQRMATIFDSQHRPFWTDNQALATLALACASAQPGVTVDERTLLDMAQELKKRQFRNGTVDNIKTTALVIQALAATGSLEREFDFWAAIRALLAAQRGDGSVGSFLDSYYVLPVLSRSTLLNVTANHCKRPETSESEALNELQDSRGSRVSVTCSVVIGTDVDLKRTWTLKVLANSSLYSIMEMVQKLDSRQKVEYNVIDGKPFVSSVMGIQDDAETGFYWFTFLRKHNAEDSILVEDSPVDVKIEANQELILWYKSGQWNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7H3</accession>
    <name>A0AAV6U7H3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000560">
        <property type="protein sequence ID" value="KAG8180522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7H3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9369" checksum="069521527BA524A1" modified="2024-11-27" version="1">MVAVRCGKAIGGSHSSLSWSVCHLLDGERVTTSFFVIVSSQQKRLHHTEQITAACNWRAGMGRDRTQRCSYICSRLLREVFVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8I1</accession>
    <name>A0AAV6U8I1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000580">
        <property type="protein sequence ID" value="KAG8180158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8I1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="147" mass="16970" checksum="BA2911BDCD3BFD21" modified="2024-11-27" version="1">MTQANDYSIIDVATILAEGKNFLQPNTSNQTILMSKDLILILILNKVARVRMFEMKVDQGKNGRETRYEGEGRTSTGFKDRRKERGEIECLVLVLFFVFRLEPETPLLLAILYASISFAQLRKDAPTPSLRLLRLRNHRILSDMLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9J2</accession>
    <name>A0AAV6U9J2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000560">
        <property type="protein sequence ID" value="KAG8180518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9J2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8201" checksum="1758DF526563B034" modified="2024-11-27" version="1">MNPKDEITNSPDAKNAGKKEAVLPLLTPSTIDLKSSASDSAAKRSPVRFPALLMPQQDKVSRPKSTVAGILFLPSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBF0</accession>
    <name>A0AAV6UBF0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thyroglobulin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_010950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000529">
        <property type="protein sequence ID" value="KAG8181178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBF0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043697795" description="Thyroglobulin type-1 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="4">
        <location>
            <begin position="100"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="119"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8181178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="149" mass="16924" checksum="B1D0563757229055" modified="2024-11-27" version="1">MRNFVTIVVLFFSTFICLTSSNQERPCEIHRRNAGAATAPMDWDIRCDALGSYLPLQCTRESPKWCACYEVDFRITQPSRYTKVCGCYIKRYRAHHNATAGPCDIPECDRHGSFKKKQCCHATDECRCVDATTGETVTEPVPDMNLQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDD6</accession>
    <name>A0AAV6UDD6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CD109 antigen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_010740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000464">
        <property type="protein sequence ID" value="KAG8182377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF172">
        <property type="entry name" value="LD23292P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043596784" description="CD109 antigen" evidence="3">
        <location>
            <begin position="27"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="4">
        <location>
            <begin position="489"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="5">
        <location>
            <begin position="761"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="6">
        <location>
            <begin position="1434"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="708"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="720"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8182377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1581" mass="180198" checksum="4F26D38577BF25F2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEK6</accession>
    <name>A0AAV6UEK6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamine amidotransferase-like class 1 domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ferry endosomal RAB5 effector complex subunit 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Parkinson disease 7 domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_017129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000477">
        <property type="protein sequence ID" value="KAG8182178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEK6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF18">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE-LIKE CLASS 1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8182178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="223" mass="24976" checksum="EFE5F035E507BF98" modified="2024-11-27" version="1">MANARHNCLIVLSGCKEGNSAQSFIQSFTLLHTNFTVQISTPGGKPLEFTNQDDQSRRWLNEFRMKSLAIPISLQTIDPHRYSCLLIPHSPGAAFDLHNDNDLGQILKNFIQEKKPICAIGMGVAALFSSIEEDCWYFSKYSLTSPSIFEIAKNGDLETLSIIPEDIIKERLATYSCSDPGEVHVVIDRHLVTGQNEQSTLTAVQNLTLLHNQKFTRKDKSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEK7</accession>
    <name>A0AAV6UEK7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_018480</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000456">
        <property type="protein sequence ID" value="KAG8182644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000104">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000321">
        <property type="entry name" value="Cadherin-related tumor suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000015">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000080">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000024">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000108">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000143">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000081">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000134">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="16"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF126">
        <property type="entry name" value="PROTOCADHERIN FAT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25374">
        <property type="entry name" value="Cadherin_FAT4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="78"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="171"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="285"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="401"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="509"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="613"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="721"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="825"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="934"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1040"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1144"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1253"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1359"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1464"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1587"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1677"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8182644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1784" mass="197797" checksum="4BBA3469F04A0163" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFW1</accession>
    <name>A0AAV6UFW1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_017098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000436">
        <property type="protein sequence ID" value="KAG8183010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFW1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="29"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8183010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="267" mass="31168" checksum="74E5AB2664FD2C7B" modified="2024-11-27" version="1">MPKYLTNMLKNIFPCLNHGTEAGPLVRASPKKYAAQLTIMDFNVLKNITLEEMSNPPFNKENTPNVDAFKDQHNFVTNWAVSEILTFQQAKNRAKLISFFIKLAVELRKINNVNSLVAVLVALRTAAIHRLEKTWDLVPKALKKKFEKMCHLIESDFNMTDLRRLQDEMKTPCLPYIAEYQSDVIRVEEMLKKFPRGEEEKAELYHKQMLNIFRPIEKCQKSNYDHLKKNALIEAYFHVIGEKLDIFKMTAQEQNNFTFKLSKDVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGE8</accession>
    <name>A0AAV6UGE8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000427">
        <property type="protein sequence ID" value="KAG8183220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGE8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="151" mass="17423" checksum="BE455C0BD5913E74" modified="2024-11-27" version="1">MSITFLSNYHTRILSSLQKNEPNSCLCWCGRLLGVVRHRRSTGGGVRRIHAGDDGRDTLKNSEAIECYKDLGLDKFNWEEGEQPSEDEIEKKQEEFKSWLEEPEQKDKKGEIMECIMKVAKKTIEDLGDSVPENCKELAIKEIHANWHTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHW3</accession>
    <name>A0AAV6UHW3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_010145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000411">
        <property type="protein sequence ID" value="KAG8183674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHW3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF134">
        <property type="entry name" value="PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8183674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18679" checksum="E330105B2B98C95A" modified="2024-11-27" version="1">MFCFQSLFNFAWKSNNEVLPFAKMATSSGNANWKSAKSIYDFSAIDIDGNEVSLEKYRGHVAIIVNVASNNQFGGQEPGTEAQIKEFVKQYNVSFDMFSKINVNGDNTHPLWSYLKNKQGGTLGNFIKWNFSKFLIDKNGQPVKRYAPNVEPNALEPDLLKYFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIJ9</accession>
    <name>A0AAV6UIJ9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000431">
        <property type="protein sequence ID" value="KAG8183136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIJ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040174">
        <property type="entry name" value="RNLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23357">
        <property type="entry name" value="RENALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23357:SF1">
        <property type="entry name" value="RENALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="121"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="390" mass="44309" checksum="1B91D7A62514AC0C" modified="2024-11-27" version="1">MEKSIVSKILIVGCGLTGSVTANLIRHEASSNTEIWERGNNVGGRFYTYHSDTDPKFSVDFGAQYFTATLEFIRSQARPIFKLHRWQPLSFATTCSLFVNDGSSLRIYDELLDMDKLVPLGQKIENFRRLSEGKMNFVAPDGTDSLVKHFLDKADAKMCLDHEVTEINLKESEKVWEVKTSSGTVKEFDAVILTIPVPEVLKLKGNFHDLIQDDDTRIALEQVKYSSRFAVALLYKEPMKSIEELPWSMKYFPKDDTICFVSVDNRKRGRNSEIPSVLVHTAKKFFEDREWSEEEVKNHIVDYIKQILPELPEPTLTKCVKWPYSQVIDAYVDNPGCLVLNEYPCLICGGDSFTESNFNGCISSALRIVEELLKHVSIAISSKKAKHSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKW2</accession>
    <name>A0AAV6UKW2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000377">
        <property type="protein sequence ID" value="KAG8184328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKW2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7675" checksum="12A35F565BC973ED" modified="2024-11-27" version="1">MLSTCSFYRKQGSCFDTNTATIVVLDPCPRARDWAPDAPPPLAGTRPGWADPSQEFLFLPLIAPLCVTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULX0</accession>
    <name>A0AAV6ULX0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">JmjC domain-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_013207</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000382">
        <property type="protein sequence ID" value="KAG8184231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULX0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056520">
        <property type="entry name" value="ARM_KDM8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF106">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND ARGINYL-HYDROXYLASE JMJD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24472">
        <property type="entry name" value="ARM_KDM8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="14">
        <location>
            <begin position="266"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8184231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="406" mass="46335" checksum="AAB6FB5CBDFE3337" modified="2024-11-27" version="1">MSGEAKFNFNLFETQIVPVLRDCNYINLPIELPGVIDEVNFLLTKCGSIFYQENIKTSDLKSCEAFAKTVLDIVWEKINTGHWKDVDPNWRYAFTFASLFKVLCLLAKKDSDKIEIIKACDTGLLMGAPLMRNILSKIASKLSTILSNESGNNRDEPKAKQMKYADDTKCLTNPVVIEKDLPKESFISLYLEKCSPVVLTGAISDWPALSTNPWSTDYFLNKARFRTVPIELGSKYTDDSWTQKLMTIEDFIQTYILNKSKQKEIGYLAQHNLFDQIPELLDDIALPSYIENESGVDISIYFGPGGTISPLHFDPKYNLLAQVVGEKYIRLYSEEETQFLYPRKNTWLSNTSQVDVENPDLASFPLFSQAKYQECVLGPGDLLHIPPRCWHYVRSLSTSISISFWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMU4</accession>
    <name>A0AAV6UMU4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000332">
        <property type="protein sequence ID" value="KAG8185547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMU4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="10078" checksum="D040884ED69A9083" modified="2024-11-27" version="1">MYNKRDDNLISIEAKMRVISYQAETMYFPSLSAQKVNVSRDQLLESASKLPCECAEGGRNLLGALQKAYVLGKVHMAALTAVDKVRRRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMU6</accession>
    <name>A0AAV6UMU6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_022378</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000335">
        <property type="protein sequence ID" value="KAG8185447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMU6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000006">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000001">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059068">
        <property type="entry name" value="TPR_P4H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23558">
        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="13">
        <location>
            <begin position="435"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8185447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="558" mass="64657" checksum="2C1361E49D16E43E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNJ0</accession>
    <name>A0AAV6UNJ0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amine oxidase</fullName>
            <ecNumber evidence="10">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_000738</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-acetylputrescine + O2 + H2O = 4-acetamidobutanal + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:70283"/>
            <dbReference type="ChEBI" id="CHEBI:7386"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58263"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:70284"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>benzylamine + O2 + H2O = benzaldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:59424"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17169"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:225238"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:59425"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="10"/>
    <dbReference type="EMBL" id="JAFNEN010000325">
        <property type="protein sequence ID" value="KAG8185755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNJ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF1">
        <property type="entry name" value="AMINE OXIDASE [FLAVIN-CONTAINING] B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="11">
        <location>
            <begin position="12"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="32"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8185755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="490" mass="55336" checksum="36778201638BFC4E" modified="2024-11-27" version="1">MDSEVIVVGAGISGLSAAKWLSEAGLKVLVLEARDRVGGRTLTKRDPKVDYVDIGGAYVGPTQDRLLRMAKEFGIENYKINEVEDLLHYKDGVRTRFRPNDLPGRRNPLVNMDINNIMWLMDKMGEEIPADAPWNAPNADEWDTMTYKEFLLKNCWTQGAIDFFKNFININITTESYEASTLSFLWYIKQCGGTKRIFSTTNGGQERKFKGGTQQVSEKIATKLGDDIVKLSSPVVGINQESKDEVVVKTLGGKEYKTKYIILACPPMIQMKIHFTPQLPPLRNQLLQRMPMGTVMKVILYYKTTFWRQNGLCGSLLVEGGDEHPMFLTLDDTKADGSFPAIIGFILADKCRRLSALTPGERKGLLAKSLAEATGLKEFVQPVHYEEKNWMEEQYSGGCYTAMYPPGFFTRYGKALREPIDRLYFAGTETAVKWSGYMEGAIEAGERAAREILYSMGKITRDQIWLKEPQSQMWTKFEPSVRSNTISSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UP18</accession>
    <name>A0AAV6UP18_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000337">
        <property type="protein sequence ID" value="KAG8185363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UP18"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="12126" checksum="D1CBBFBFD63960EB" modified="2024-11-27" version="1">METVLRGLSYEACLVYLDDIVIVGKEFNDHLINIRKVLTKLRYAGLKLSLSKCHFFRRKVKYLGHIVSSAGVQTDPDKTEAVKNWPRPKDVHELRSFIRICLHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPM5</accession>
    <name>A0AAV6UPM5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orange domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000327">
        <property type="protein sequence ID" value="KAG8185664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPM5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orange" evidence="2">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8185664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="192" mass="21326" checksum="982C249CCE1EA8D7" modified="2024-11-27" version="1">MPDVRDSSEESDLVATAAEDDRYAELLLAGFRACAREAIRFLLEEEGLSPNHPLPSGLNEHLLRQQCHLAGTLQNDSGVDFEESFLNCSTDGDTKSPKKRNCQLEGTLESDSSGVDYSESFLNCSTDGDTTLLRKRRRFENETDGTSIDGDEDVVKISQCNLSAKMTEDMIKSEPESVQRTEEQTSHVETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPZ0</accession>
    <name>A0AAV6UPZ0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000326">
        <property type="protein sequence ID" value="KAG8185693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPZ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="129" mass="14832" checksum="51C955D0883301E9" modified="2024-11-27" version="1">MDNGSRRFFPISPSDVPPLDRVALQLQLGRRFVMAKINGPEGLEKKEKLSSNCGVHIFQRFGHVKIFPPEEIFTTKEERKDKSFSRTFPAKKEAISRDLFVAIFFSTIRPWNFSLEDLSLVLEKSSDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQC6</accession>
    <name>A0AAV6UQC6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_004831</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000299">
        <property type="protein sequence ID" value="KAG8186501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQC6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8186501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="262" mass="29152" checksum="0C2B96133E7D4C17" modified="2024-11-27" version="1">MMNQLCKVCGEPAAGYHFGAFTCEGCKSFFGRTYNNLAALGECKNSGQCVINKKNRTSCKSCRLKKCLLVGMSKSGSRYGRRSNWFKIHCLIQDQAEMSSRLGEQGVLANSHYDSNKELVHHFRPDFSEGPSNRGSPSSDPLESTSYGYFPSASSYSNGYEAGSSPTYETRKENFHHLPLSPVSPLHPAKFFFHSAAFSKFPKEMKFPVGPVQENPIDLSVRKPETPTSDATVDEDEYINMDDEPQRAETPLDLTAKRVLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6US62</accession>
    <name>A0AAV6US62_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NOL1/NOP2/Sun domain family member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_020048</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15836"/>
            <dbReference type="Rhea" id="RHEA-COMP:15837"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000277">
        <property type="protein sequence ID" value="KAG8187176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6US62"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000055">
        <property type="entry name" value="5-methylcytosine rRNA methyltransferase NSUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF3">
        <property type="entry name" value="5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="115"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8187176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="437" mass="50213" checksum="2C5A0C19F1DB25D1" modified="2024-11-27" version="1">MLQHLNRLRYLRFLKKPYEFNIRQYSTPRVKQPGSEIALNHFDQFYSSIFENWSSIRLGLLCPHSYCAVVNVFSREKSPAELFPDMEVFNMKDAYYLQLGELDDMSTAPEPPLQNTSKDNEQFTSAMNLNQPPSESEDYNEFMPATELKHRDLDTEEFADFYDPNIKYDAQVIKHGVIHYPEHWEMYYCPRGRFKKFPPPKEDISGLLNYYLMDGASLLPVFALDVQKGEEVGDLCASPGGKTLAILFGLRFGKIVCNDASLSRVNKLKTVLSSYLPNTQEWSKKILVSNLDVCDWRCFELFDKILLDVPCTNDRLSVTKDANNIFTQKRYNERMHIPRTQTSMLCAALQALKPGGSLVYSTCSLSPIQNDGVVHMSLAKLSVECPFEFAVQDLTQAFLPFKSMFQYSDTCQYGQLIVPFLPLNYGPMYISKITRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTK2</accession>
    <name>A0AAV6UTK2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_015602</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000261">
        <property type="protein sequence ID" value="KAG8187732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTK2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10332">
        <property type="entry name" value="SLC6sbd-B0AT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002438">
        <property type="entry name" value="Neutral_aa_SLC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF182">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01206">
        <property type="entry name" value="ORPHTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="622"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8187732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="703" mass="78724" checksum="265BC06BEEAD2B78" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUZ1</accession>
    <name>A0AAV6UUZ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_012120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000244">
        <property type="protein sequence ID" value="KAG8188287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUZ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06105">
        <property type="entry name" value="ScCit1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8188287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="465" mass="51557" checksum="4F1883D87236973D" modified="2024-11-27" version="1">MALFRVFANRLVAQPQAYAPLSVFSRNLSDTTDLKGLMAKKIIEHQKAVKKFREMYGSKVIGEITVDQIYGGMRGMKGLVTETSHLDPEEGIRFRDLTIPECRAQLPKAPGGEEPLPEGLFWLLLTGDVPTEAQVKHLSKQWAELADLPAHVVTMLNNFPSNLHPMSQFAAAVTACNTESKFAKAYSEGVSKTKYWELTFDDSMSLIAKLPPIAAIIYKNLYRDGSSIGAIDTNKDWSHNFTSMLGYEDPTFTELMRLYLTIHSDHEGGNVSAHTVHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLTKLQKDLGGDVTEEQMKEFVWKTLKSGQVVPGYGHAVLRKTDPRYVAQREFALQHLPQDQMFKLVSTIYKVVPPILLELGKVKNPWPNVDAHSGVLLQYYGMKEMSYYTVLFGVSRALGVMASLVWDRGLGLPLERPKSMTTDGLMKLVGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWF3</accession>
    <name>A0AAV6UWF3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_009194</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000230">
        <property type="protein sequence ID" value="KAG8188805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWF3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000012">
        <property type="entry name" value="RB-associated KRAB zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000770">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8188805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="411" mass="48205" checksum="AE3D21E04AF96B4B" modified="2024-11-27" version="1">MSQFNSFMPSNDNIIIKTEIEDNITRITVIPFVCHLCKKAFTQLIHLEEHLETHNAPSYDCPADDYAEQISQQDDNVFEFECHFCCQGFENEAILLEHYTEHELNNPFACDMCDKSFKSKYHLKQHYVCHTGLKPFSCEVCGKCFRKKDYLQVHYLLHTGEQPFACNICHKRFLTRLNLQQHYSLHTGERPFTCEICQKSFRKKNTLNQHQRTHTSLKPHVCDMCQKGFKTKGDLTQHYLVHSGEKKHICDVCMKGFKTKAECQKHMRIHSEDKEFYDCDVCHKRFTSKGYLKQHVLLHTGERPYLCEYCNKSFPLKTHLQKHYQSHGSDRPYKCCVCLKGFKTKGTLQQHYSIHTGKKPFVCECCKKCFALKSQLKRHMLVHSSEEQSTTENMQNALNCNNEVHQVGDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWI4</accession>
    <name>A0AAV6UWI4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_005503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000264">
        <property type="protein sequence ID" value="KAG8187651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWI4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8187651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="428" mass="48434" checksum="126C8E883C2B3565" modified="2024-11-27" version="1">MALQSMAADSGGSYEPLQLEPFIHQVGGHSSMLQLDEDTICKPLISQELNFYKTAPDALKEFMAEYKGMIEVTYSESDDGYLDLTTYLPATYKKSSSKQSSRQNSLTENERKAKHRDLQKYPPLKMNCYLPRIRLCQSGKIQIDSITIDDAKKNYEEQRNRTGKAPNGSLNPWVAYCHQKHVRDLQQKSASTFSQKYILLENRVSKYEFPCILDIKMGTRQYGDNMSQAKKQSHTAKAAASTSAILGVRLSGMQVYHQESGVYNCHNKYYGRSLTVDGFQQAFFNFLHDGVKLRRNVVSALLEKLRKLHSAIRNLNTFRFFTSSLLIIYNGSEASSKFLNDNGNKEGKVKTDKSCDKCSSVNPCRKHVSPPRKSNADNVVDVCMIDFAHSTHRDMPDSSVSHEGPDEGYLFGLENLITHLEVIQQAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXZ4</accession>
    <name>A0AAV6UXZ4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000233">
        <property type="protein sequence ID" value="KAG8188703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXZ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11698" checksum="D34339F3CA8BC58E" modified="2024-11-27" version="1">MPNKSLLIGDLHGGLFIHYWKQILETVVSGEKANFSGVGERNIVLWIRIRSPRGPPMLFFSTWTAILLVQPTGRHRQTAFVFVDCLCFDWVIYGVVVSSSFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZY8</accession>
    <name>A0AAV6UZY8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000220">
        <property type="protein sequence ID" value="KAG8189146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZY8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="8261" checksum="610EF2573F3A5695" modified="2024-11-27" version="1">MERLHHNRTVWIREKKEYARVEMLQSSCLQARQKLPVKKERGDDSPSGPMDRVAGMWDLARFRHEKLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0S7</accession>
    <name>A0AAV6V0S7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_023655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000211">
        <property type="protein sequence ID" value="KAG8189587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0S7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="48"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8189587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="405" mass="44732" checksum="1D6A0A9E5AC8FC94" modified="2024-11-27" version="1">MAGTLNVVRFGGVSNSSHVGNTSAPNCHPAQTTESVVLFSLALLGMGANTFLMFLILTKKPLRRWSQGLLFHQGLVDCARASLLIPLGISVLLCKRMPNCSIVETAFLLLVTVSTVNILTSVINDAPLMPEQNEVSNDDSDGGYTINSENNHVVLDSPQCIIFGLFIIWFASFTINLGPTFLSGALSSAREGVALIDACPMVYAPVRHYVLNALWVTVNLMCIILTGIHLRKLYRDLTKSNLEALRIAGLVTTMISVRSERELCESQQIQSYINRLEKDGIRRVKMFVVLLVAYLLFWGPLFIVILIQPGVQGPSTSYEMSLHVAFAHTFVNPTLLLVLHKELRHASAGACCCHNFCDPEEQDVPYEPSTAACRLNRSYMTKEETSPIRSLSFIQKHRAVDTSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V405</accession>
    <name>A0AAV6V405_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_016665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000165">
        <property type="protein sequence ID" value="KAG8191152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V405"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058883">
        <property type="entry name" value="DZIP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25977">
        <property type="entry name" value="DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8191152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="696" mass="79400" checksum="AFFC894B7A97A056" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4Q3</accession>
    <name>A0AAV6V4Q3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000172">
        <property type="protein sequence ID" value="KAG8190888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4Q3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="10389" checksum="1F29DE1AC6D49E39" modified="2024-11-27" version="1">MYNGLTLHSNIHINKTFTFHKIFSNNSFKARLGIVDQLFLRSSHRSPKSNFSVSEWMSLCEGNPNLKGVSSLRTTCQMDLCHFHMIWIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5Z2</accession>
    <name>A0AAV6V5Z2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000167">
        <property type="protein sequence ID" value="KAG8191086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5Z2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21404" checksum="E30C746C83CEA7B1" modified="2024-11-27" version="1">MCLLIQHCVKILWLYEKQLRNLIFCSSCLNTLKDFFSALEIVRLLRNALSLPLLIALMISLLNLFISISTLLIESMDVATILALEMLVTSLNGSIILLTLTLQAAKIPDSLTKIKGTAGTLLVKHSKHNFQNRIAKETMYLLRRIEESELIHLSACGLIEFKKSFLLSAVGGLSTYGLLVLNFKRTDIKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6W4</accession>
    <name>A0AAV6V6W4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_006125</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6W4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140693">
        <property type="term" value="F:molecular condensate scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140694">
        <property type="term" value="P:membraneless organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13983">
        <property type="entry name" value="STKc_WNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001054">
        <property type="entry name" value="Serine/threonine-protein kinase WNK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase WNK1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024678">
        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="259"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="21"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="210"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="610"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="702"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="777"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1064"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1177"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="643"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="724"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="805"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1100"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1192"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8191381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1272" mass="140144" checksum="983E803AEA2E012D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7L0</accession>
    <name>A0AAV6V7L0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000139">
        <property type="protein sequence ID" value="KAG8192442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7L0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="129" mass="14033" checksum="B26B79268BAE962A" modified="2024-11-27" version="1">MSKSFLVDSLLTKSANPPKDSTTPKNNINLWTNQNNVMLPPGLCISPHGLCGSPMGFSEYFQRGFYTYAANGLSGFQDSANGTSAFQIIGSSNTNRSFETAKSYSKEVWPAKSFSSAAEDTGELYFVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7N3</accession>
    <name>A0AAV6V7N3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_017184</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000137">
        <property type="protein sequence ID" value="KAG8192619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7N3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1770:FF:000001">
        <property type="entry name" value="Cytochrome b reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF24">
        <property type="entry name" value="NO EXTENDED MEMORY, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="30"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8192619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="256" mass="27819" checksum="19B25BB62BD3BC32" modified="2024-11-27" version="1">MGTKKHESSSSSEGGAPLAARCGFGWLAFVAELLLAGSLALVLFWVFHYHGGVAWSGDGSRQMNLHYVLMIAGFIFMNGHSMLVYRTFPCFRKPYLKAIHALLFVGAIACVCCGMWAAIDAHNDGPAPVHFYSMHAWIGLVACGLFGLQFLFGGFAFVVLLCCDVATAKFRAALLPTHVTVGLATFTVAAIACLTGLMQSARYRLSGKDGKPDYKDLEEQGIIVNTLGMCVVALCIVIPYIIRNSNYRRYTTLTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCY7</accession>
    <name>A0AAV6VCY7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyribonuclease TATDN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_013269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules. Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCY7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8194517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="336" mass="37547" checksum="CCACAEB6E0D86DED" modified="2024-11-27" version="1">MSLNLIKEPNKLKNLTNSIHFTMSNQAVSNPQEQSVVSSGGAEAALEVLSGQYFVTDVCASLTNKKYARDLDGVVQRAKNAGVKKIIVSGTNIQSSKEALRLTRLYPDYIYCAAGVHPNEAKTWDNDVQSTLKEILSNAECVAVGQCGLDYSKNLSEPEEQKEVLSKQLNMAAELKMPILICEREAHNDLVQILKNNIHNLPQIVIHSFSGKVDELKTFLSLDCYIGLTGSIWKDKTEDSLKKILEDRLIPLDRLLIESDSPYMYPNTRASQIPTTIKETLSEKSLSFLNRYCTFQRNEPCSLPVTIELIAAYYQMKPDEVALQTTFSAMKLFGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFP5</accession>
    <name>A0AAV6VFP5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000097">
        <property type="protein sequence ID" value="KAG8194888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFP5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="39808" checksum="6B668D927B5AB79C" modified="2024-11-27" version="1">MFDVDIGLLEGETERTSVSSLKAISAEVKSGSNTGSTYIYLCRNSTFYVHLALKRVGRFCAGFLKMSVKESNYLLSCEDDENNLVKFLTTMTDYFWQKYDFENLRDPEDLNKVLFRMALKVSHSGDEILWKFTWEKIQLFHLEEYVLTEANYAVAVSTVINCEEHRPSILRTAKLHLDNLDYRRMLTCVAFTAIKSHGSSSDVRYQWIWKRIEEATAEIKVLLEQNYFFIKTVMDLSDANLLKRALQTAMVYLDKEQMHHVYKEAYLHAVKWHGAFVNEKIWNATLSLQTLKKVSCRHQWDNLFEHLDGYKCVKETKRSLDLPLENVNDSNKKTRLADEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHQ1</accession>
    <name>A0AAV6VHQ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetylcholinesterase</fullName>
            <ecNumber evidence="2">3.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_003811</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000081">
        <property type="protein sequence ID" value="KAG8195666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHQ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="34"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8195666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="555" mass="62351" checksum="1C44AA1AC04F6CA4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIT2</accession>
    <name>A0AAV6VIT2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000071">
        <property type="protein sequence ID" value="KAG8196390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIT2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12105" checksum="7A6C1F4303E3ED1E" modified="2024-11-27" version="1">MSIDGRVFLEFVGQELLGANYDVKGHAGQKRSTSKKTQTNKSAPTTKKTAAKKTSKPRKNSAKKKTSKSKKKSAGKKKASKTRKSSTGKKKKKKKSPKRSAVPASKQHLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJ14</accession>
    <name>A0AAV6VJ14_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_007844</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJ14"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001607">
        <property type="term" value="F:neuromedin U receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005390">
        <property type="entry name" value="NeuromedU_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01565">
        <property type="entry name" value="NEUROMEDINUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="61"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8196108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="401" mass="45246" checksum="10C4D74D7C9DEAEC" modified="2024-11-27" version="1">MEETSEDLENQTYIYYNFNYSMYCKNYSLVECHIGPIRDPLTTVIPMTLVYSIILMTGVLGNILTCIVIAHNRYMHTATNYYLFSLAVSDLLLLVLGLPQEIYMLWYRYPYFFGESFCILRGLSSEMCTNASVLTITAFTVERYYAICHPFRAQVMSSLPRVVKTIVCIWFGAAVCALPTALQLGISYHEYPEGGDILESASCSVVSPIPHIFEFSTGMFYALPLLIISVLYVLIGLRLRRASIGSHPDSINDGNHVSKQKMNSRKAVVKMLVAVVILFALCWSPFHAQRLMAIYVEVTQIPITVPLENIFNTLTYVSGITYYLSATINPILYQLLSVKFRQALKDTFTCSGGQTDSEREMTSLHCDNRNRIAVKKVSSVSYVGEDPRPNDVCDDPLLKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJ67</accession>
    <name>A0AAV6VJ67_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD finger protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_027558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJ67"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15674">
        <property type="entry name" value="ePHD_PHF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15561">
        <property type="entry name" value="PHD1_PHF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15562">
        <property type="entry name" value="PHD2_PHF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF150">
        <property type="entry name" value="PHD FINGER PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="143"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="218"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="552"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="462"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="617"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8196845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="81884" checksum="911764BB0E6225CE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJ93</accession>
    <name>A0AAV6VJ93_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dystrobrevin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_006579</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dystrophin family. Dystrobrevin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000066">
        <property type="protein sequence ID" value="KAG8196669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJ93"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16244">
        <property type="entry name" value="EFh_DTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017432">
        <property type="entry name" value="Distrobrevin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF27">
        <property type="entry name" value="DYSTROBREVIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038204">
        <property type="entry name" value="Distrobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="12">
        <location>
            <begin position="220"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="472"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="559"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="395"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8196669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="693" mass="79141" checksum="6FF2DF7FE83FA36F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJU0</accession>
    <name>A0AAV6VJU0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000072">
        <property type="protein sequence ID" value="KAG8196313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJU0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="153" mass="17409" checksum="9577822E6CA8DB6D" modified="2024-11-27" version="1">MDRLEWSRGTSSWARLLSGGRVQRRLRPPNVVHTYGPVGMESRNPSRARLLSGGRVQRRLGHPNVVHTYGPVGIESRNLVVGPTPKWWKSLTAFEAAQRRLHLWTGWNGVKEPVASPTPKWWKSPTAFGASQRRSHLWTGWDGVEEPRRGPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VK88</accession>
    <name>A0AAV6VK88_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000059">
        <property type="protein sequence ID" value="KAG8197084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VK88"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="128" mass="14911" checksum="BF75C0E95B446D6C" modified="2024-11-27" version="1">MKPKQKITKPTPSMKSSVMQRLLKWIQRKYVENGCVTYNEVKEFLEINEKYAYKVQGIMEVLLKNGHFEKFGWKYIVPTPSRSKILKQVHQAAATNQGKQKRTHSNKDIPTSTIFSEDFEITSSDDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VK99</accession>
    <name>A0AAV6VK99_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_012296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000069">
        <property type="protein sequence ID" value="KAG8196478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VK99"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000001">
        <property type="entry name" value="YTH domain family 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF89">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="YTH" evidence="5">
        <location>
            <begin position="380"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8196478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="540" mass="59504" checksum="618F838FDD9EB857" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKD9</accession>
    <name>A0AAV6VKD9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_009578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000071">
        <property type="protein sequence ID" value="KAG8196359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKD9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF3">
        <property type="entry name" value="AT07710P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="1">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8196359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="545" mass="60713" checksum="D644150B2FEC2FDC" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VN10</accession>
    <name>A0AAV6VN10_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000047">
        <property type="protein sequence ID" value="KAG8197944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VN10"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8369" checksum="610977A4293C679D" modified="2024-11-27" version="1">MKIRRLAFNLNGCTITANQSNQSTTFQSPNTFQLTLIIDEKYTNSDKPAHFPLVSNDTQHVSNPPFPYIKTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNF3</accession>
    <name>A0AAV6VNF3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNF3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7651" checksum="8CBEAA8B69BE558E" modified="2024-11-27" version="1">MLVTLIDCKGRTYPVEVNKGLVSGQCGSSQFSEFSPRAQTTPQTGQDKRSRVDSLRQHVESTKCYVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNW4</accession>
    <name>A0AAV6VNW4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNW4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7768" checksum="BC00282D1A553C22" modified="2024-11-27" version="1">MRTCERNRSSLSFSSLPYSLSITPKSSEKIGRGKGNPDEKEMENYRIPASFSLANRSIGKPDLLISLFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP50</accession>
    <name>A0AAV6VP50_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Piezo-type mechanosensitive ion channel component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_022198</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIEZO (TC 1.A.75) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000040">
        <property type="protein sequence ID" value="KAG8198465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056769">
        <property type="entry name" value="Piezo_TM1-24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031805">
        <property type="entry name" value="Piezo_TM25-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056768">
        <property type="entry name" value="THU_Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049:SF2">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24871">
        <property type="entry name" value="Piezo_TM1-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15917">
        <property type="entry name" value="Piezo_TM25-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23188">
        <property type="entry name" value="THU_Piezo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
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        <location>
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        <location>
            <begin position="728"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="879"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="915"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1050"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1093"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1213"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1236"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1269"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1703"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1731"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1757"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1934"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1975"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2004"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2072"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2148"/>
            <end position="2171"/>
        </location>
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        <location>
            <begin position="27"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM25-28" evidence="13">
        <location>
            <begin position="1189"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo transmembrane helical unit" evidence="14">
        <location>
            <begin position="1712"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo THU9 and anchor" evidence="16">
        <location>
            <begin position="1932"/>
            <end position="2170"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="12">
        <location>
            <begin position="2207"/>
            <end position="2500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="318"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="808"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1486"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1862"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2500"/>
            <end position="2520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1537"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1872"/>
            <end position="1891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8198465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2549" mass="292179" checksum="2626FF42597872F4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRE2</accession>
    <name>A0AAV6VRE2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRE2"/>
    <dbReference type="Proteomes" id="UP000827092">
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    </dbReference>
    <dbReference type="GO" id="GO:0007165">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="226"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="838" mass="95117" checksum="E8B1321C9C0F5C4B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRK7</accession>
    <name>A0AAV6VRK7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRK7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="11193" checksum="A92CF4EB18E46412" modified="2024-11-27" version="1">MTEKFLLTLLFFNVTYFASLFVITQLKVKPMPMNSLEHFVEPFRKKVSSKAARDVHDILNLGDPDSQRCQLCQTKAVKQLADGAHSFSGASTLPHALGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTM9</accession>
    <name>A0AAV6VTM9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_009323</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTM9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8199475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="181" mass="20617" checksum="FF81469F5F94D560" modified="2024-11-27" version="1">MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERIGEAREELMRMLAEDELRDAVLLIFANKQDLPNAMNAAEITDKLGLHSLRNRNWYIQATCATSGDGLYEGLDWLSNQLKNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTR9</accession>
    <name>A0AAV6VTR9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000034">
        <property type="protein sequence ID" value="KAG8198851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTR9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="141" mass="15920" checksum="D5D1F6A6792BC7C9" modified="2024-11-27" version="1">MKRAKDAKVVDSIVHKDAGYRVLNSEHCLPSFWESKKVLMAMIWQLGLLTFFFMRSTAVQKLTGKSKEEYLSLKKSTVFGKGSLNDLAVNTYNTTILSLCGSNMDQQFVLKAFACAHYILSYINKSDRGISKLIHDSLEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VU02</accession>
    <name>A0AAV6VU02_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Meteorin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_009432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the meteorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VU02"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051998">
        <property type="entry name" value="Meteorin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28593">
        <property type="entry name" value="METEORIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28593:SF3">
        <property type="entry name" value="METEORIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043675390" description="Meteorin-like protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8199595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32434" checksum="3BA26740AE035E5E" modified="2024-11-27" version="1">MRLIICWLLGFLLINSVIASGPSMDNCDWVGSGTLAMALSKSIQPVYLRCNQGTVQWRYPQGALRIVLQHRTPGTPFSACIRRSSTSSGARIHLAGKTRLHRVFSKEDPADLVRCVGSVDGKVALYVEADSIGSVLRKEMMDFSYYLKRRTRRSVKEFTDDCQPCSESELLRQYCSSDFVIQGSVASLFNNKQLQTTELTVRVSRVHRTNSVQTFTQLSDPDIPLSGSTGYVILHRPLRCGTKSGSGEYLFLGNWILGNPSLNCVPRMAEWKKVRRKAMKEGTNECILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VX53</accession>
    <name>A0AAV6VX53_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000004">
        <property type="protein sequence ID" value="KAG8201582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VX53"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8932" checksum="95741D4BB43F223C" modified="2024-11-27" version="1">MKNVLPQDILGAAAGCGLALFIALSAIVCKYYSRTRKERMILYSPPRRPSYERRQKKLLRMREAAAAEATQQQVRTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXL4</accession>
    <name>A0AAV6VXL4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras-related protein Rab-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Small GTP-binding protein rab1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_028845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Protein transport. Probably involved in vesicular traffic from ER to Golgi.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000008">
        <property type="protein sequence ID" value="KAG8201190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXL4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001018">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8201190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="207" mass="23931" checksum="F179081FF2FC4F04" modified="2024-11-27" version="1">MAAEFAATYKILVLGDSNVGKTCIVHRFCDERYYDTYISTIGIDFKQKIINLDGMPIKLQIWDTAGQERFRTLTTAYYRGAMGILVMYDVANMDSFNHLEYWFRNVSENASQDVVKVLVGNKCDATNLRVVDFEKGQKVAENLDIPFFECSCKNNENIHESFLELARKIREQREIRATKFDEMERLQWEKADLNQSKPVSGAYRCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYK0</accession>
    <name>A0AAV6VYK0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYK0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="10312" checksum="71BC99D82009AB5A" modified="2024-11-27" version="1">MLLRYEESLFLFKMLECSFMVFGLTLNIDPPPPPLKKKAKAHFYFFSKFKLEARMVNKGLKCQFLAGSGRKAMPPQLVDFAAARFKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W0Z8</accession>
    <name>A0AAV6W0Z8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pikachurin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_024323</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W0Z8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016318">
        <property type="term" value="P:ommatidial rotation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050769">
        <property type="term" value="P:positive regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048056">
        <property type="term" value="P:R3/R4 cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043697838" description="Pikachurin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="170"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="9">
        <location>
            <begin position="215"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="394"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="9">
        <location>
            <begin position="436"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="612"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="9">
        <location>
            <begin position="654"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="807"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8201453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="835" mass="91838" checksum="20FA56977FC8FD0C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W348</accession>
    <name>A0AAV6W348_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_027323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W348"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043686614" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="149"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8201843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="293" mass="34212" checksum="289FE93091F8CD8C" modified="2024-11-27" version="1">MGFARIWGLCLVSVSIVVCLVNSQDYPNIDPDDLPRTRFTCKNKVPGGYYADIETGCQMYHVCYKSNDGLMQDTKFLCGNGTVFDQRHLVCQDYEKVRNCEDSRRFYRNVPKGLKEPRIVRMRNTERIREVTYLKDFPRYSADDLPQTRFTCKNKVQGGYYADIETDCQMYHVCQRNKIGRLESTKFLCGNSTVFDQRHLVCQDYMRVPNCRDSRKYYRNGATILEELEARMMRSGSSCHGFKLDAIRTYGYDVQLRIRLLSTNLPQPPTNHCDTYQWHPQEKSSPQSPNSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W572</accession>
    <name>A0AAV6W572_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium-coupled monocarboxylate transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_010385</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W572"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8202014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="80804" checksum="DCA59DF02EBD590F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W5L5</accession>
    <name>A0AAV6W5L5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_010413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W5L5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12354">
        <property type="entry name" value="RRM3_TIA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000317">
        <property type="entry name" value="Rox8, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="124"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8202046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="324" mass="35569" checksum="865FBBFFF78136FB" modified="2024-11-27" version="1">MHSFTFPKSSANGSHQRINDKYALASDSSGPRSQILSQSLGSSDCRVVRDPQTLKSKGYGFVSFVKKADAENAIGTMNGQWLGSRAIRTNWATRKPPANRSQNDTNAKPLTFDEVYNQSSPTNCTVYCGGITQGLSEELMQKTFTPFGPIQEIRVFKDKGYAFVRFATKEAATHAIVATHNIEVNGQTVKCSWGKEAGDPNNQQQQQQEILSVEAVENKGFLTMLSQNLAAQYTFPYQQMSYWYPQGFPQVQGQFIQGMQYPYGQYYGQGFGMTGMQMAWQGIPGQPQIAAAAAAAAAAQSPLAQGLQQPGMIGAYPMQQYQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W698</accession>
    <name>A0AAV6W698_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acidic fibroblast growth factor intracellular-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W698"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008614">
        <property type="entry name" value="FIBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13223">
        <property type="entry name" value="ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13223:SF2">
        <property type="entry name" value="ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05427">
        <property type="entry name" value="FIBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8202156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="43615" checksum="643CE5E14E9160A7" modified="2024-11-27" version="1">MSETANDDSDIEIDIFVGNNTLLDPEIYDMWLAGQDAAEGTTMLINGSLKDFDMDYNMLLSDVLDHYRTFQMLERLLHYPKRLAEQWIFQISESVQRMLIERYYEFEDSVIREFLGKKLSARNRKDLDDVSEKAGVQVKSCRRQFDNVKRVYKIVEECSGDLVESIQATFMLSENLARKYAAIMYLTSNRFETSKRKLQYLSFDDFLYCANWMMINWGCPKPDCSFEETPLEMDREFLQDLRELKQILDRESFDDLKSFVLSSMKKKLSDKAYSDLESNFKSCTRSFVNIAAGLNHSKEVRDLFIDIVEKFIEPFRQNRLSDKDLRCFLETFTSAAPHIRLLKSDPHLMDIWDRYMSTMCRFILKMYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDA3</accession>
    <name>A0AAV6TDA3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006467">
        <property type="protein sequence ID" value="KAG8155914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDA3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46703">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46703:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11066" checksum="55A2DBC723C4C672" modified="2024-11-27" version="1">MGLIFPNPDTEIGPSGPSAVTQPNSETSTEDPGKSYLFFVRVRVPGIGSSGDRDAVLVKAPRLLRCPVRLCWPLKIRGLFSCRSVPISAAGLQGEQPLVTRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEF4</accession>
    <name>A0AAV6TEF4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006181">
        <property type="protein sequence ID" value="KAG8156216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEF4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8156216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="67158" checksum="1D1A71B5B1421DA9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEY8</accession>
    <name>A0AAV6TEY8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005606">
        <property type="protein sequence ID" value="KAG8170363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEY8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="7984" checksum="FDE120376A5F64ED" modified="2024-11-27" version="1">MATEGGTKRQANSHWEGGGNTACRKGSRTGGRLVTGEEVPGYPGRGGSPSRVGGGKHSGDEGAQFTSQVVGPKEEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TG96</accession>
    <name>A0AAV6TG96_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004766">
        <property type="protein sequence ID" value="KAG8170850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TG96"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="62" mass="6773" checksum="2E5779FFCC776C2D" modified="2024-11-27" version="1" fragment="single">ALGMNPSMSALSTVDGRLCAYHGRKRVNGDQGSIPEREPEKRLPHPRKGSRRANYPLPGTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TH91</accession>
    <name>A0AAV6TH91_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004707">
        <property type="protein sequence ID" value="KAG8170898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TH91"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="308" mass="36603" checksum="56813F7AB59EC168" modified="2024-11-27" version="1">MTKKKRAYSSQSRRSTRKQGPANSRASSQTIHTKERIQIEEEKKQKKTAQHSRSKAKQGKNQRKAVERQQPTKKQTHHKNKQPKKQTDREGGQEQKETNRKRKIKTAAAKKGNRPKQRSEDKQQKRDTENKKPRETQQRKAKQRQAEPGRHHTPRMKIQNHPPEESKEQEKKKPQENREPKQERKRRRKREGHKKPEQQEKGEEDHNHRKPATKQPDRNRKAKKKPEHKKEKQRRKNTKRPTKPQENHQTTHRKDSGRPPKKKAAKKTTSKKATGQKTKKPANKSNKTRKREQAPKRDQKQERARTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THC7</accession>
    <name>A0AAV6THC7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004459">
        <property type="protein sequence ID" value="KAG8171082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THC7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="189" mass="20990" checksum="4653836933F07BB4" modified="2024-11-27" version="1">MVTVNYRLGALGFLRFRHGRRKPGPSKVLPTSTETVPTTTSSWRIDSLRRSAVVLLSQKNPKDTVDCLKGVESSRLVQTLASFSPVFQQPPNVFLPQFGRDDLIPLGDPFAILDGRFNYYDKKDAFLAYTTEEGSYLLTVNNPDVFGVFGEKDTGIDDVQAKSMMTKFLENFPQPMSSTSPIGKCTSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIB5</accession>
    <name>A0AAV6TIB5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PI31 proteasome regulator N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003942">
        <property type="protein sequence ID" value="KAG8171460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIB5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047118">
        <property type="entry name" value="Fbxo7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15537">
        <property type="entry name" value="F-BOX ONLY PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15537:SF2">
        <property type="entry name" value="F-BOX ONLY PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="1">
        <location>
            <begin position="39"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="152" mass="17410" checksum="EB9697D96840577D" modified="2024-11-27" version="1" fragment="single">KIAYEKSIPVEMNLMNEIEVSNQEEDFPKGFLDLYSSVKIESPSDSFTLLLHSVLLEIGFTPNDVESDNVYQQMPENWKSHGIFKIQYYHKTVPEALCWVTCVPLHKSLAVEGSLVSQSSDENNAHKNLSIKDFVDEKEDISSKLKINFKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJL4</accession>
    <name>A0AAV6TJL4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulator of rDNA transcription protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003074">
        <property type="protein sequence ID" value="KAG8172125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJL4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12283" checksum="1B51470206C4A91D" modified="2024-11-27" version="1">MNAWLPRASYPCGNSSDTSCIKLVKSKGSIGPAFAVRIHTENQDQASFCPFALREVSVLAELALGHLRYHLTDVPPQPNNPPESVLGADRALQGGSALGARSVILTGRFPLNRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJZ8</accession>
    <name>A0AAV6TJZ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003609">
        <property type="protein sequence ID" value="KAG8171740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJZ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="113" mass="12974" checksum="6512E4B0626ADA3B" modified="2024-11-27" version="1">MFENDMKEKKTGIIEIEDLEDDTVNKMLSYLYTNAIEELDSSTAQKLYYAADRYGIKALLRICSNHLMHNLDTSNVCEILVLADTHQDEELKSYAKDFILVHVQEVINSNGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLH9</accession>
    <name>A0AAV6TLH9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial glutamate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_009316</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002505">
        <property type="protein sequence ID" value="KAG8172645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLH9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF5">
        <property type="entry name" value="AT03939P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="89"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8172645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20027" checksum="C464640199B5B98C" modified="2024-11-27" version="1">MELLKIQLQDAGRVAGSAAAKGTAESGTVVATSATSIALQLIRTKGITGLYKGTGATMLRDVNFSVVYFPLFARLNALGPRKNDGSGEAVFWTSFLSGCVAGSTAAFTVNPFDVVKTRLQVLTKASGDATYTGIIDAFTKIMKNEGPLAFFKGAGCRMIVIAPLFGIAQTVYFLGVAEWLLGKKRSDGSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TM84</accession>
    <name>A0AAV6TM84_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002255">
        <property type="protein sequence ID" value="KAG8172907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TM84"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="121" mass="13883" checksum="5C62D71629C262EA" modified="2024-11-27" version="1">MHVQHVQNNYAAGNIRPQLVWDAAQRLSSSPLYEEYGIGLCSSWMDDVNDFSIAFEFEDKEFLDNFFDFENQEENDKEQTVWPEDEITDCNPGGIETLISGEEGLRMAPAEGYRPISVLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMY6</accession>
    <name>A0AAV6TMY6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002226">
        <property type="protein sequence ID" value="KAG8172934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMY6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11250" checksum="AA49CD581DB7E035" modified="2024-11-27" version="1" fragment="single">MTVQHCQANNFVTTVQSNILKSKAKTVKILKKIEDLLSLPMLLVCTANFGACCSIVGKIPIEMASLRSAFCEKVDIRLLLNPAPGEVKLERGLYDAPDFILTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNS3</accession>
    <name>A0AAV6TNS3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_010927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001703">
        <property type="protein sequence ID" value="KAG8173500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNS3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000003">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8173500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11349" checksum="8026E5DF1D9B7FBA" modified="2024-11-27" version="1" fragment="single">GKHGDALKILLRSAPTGTKNQCIKDAAINLVLKVILSIKTSDIEKTVSTLDRDQIDVLMKYVYKGFENPSEGRSAILLAWHEKVYAVGGIGSIVRVLTDRKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPM6</accession>
    <name>A0AAV6TPM6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_006263</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010001661">
        <property type="protein sequence ID" value="KAG8173544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPM6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000007">
        <property type="entry name" value="Thioredoxin-dependent thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006960">
        <property type="entry name" value="PRK09437.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF4">
        <property type="entry name" value="AHPC_TSA FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="69"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8173544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="223" mass="25604" checksum="98E7B823A9BEB6B4" modified="2024-11-27" version="1">MIDFMDNQSEITLQRIEENPSIHSSNIATRIANELQEYNSRRSSEINESIHHKMQLLDENYNMEQGMELAVGNSAPDFSLPADSGENLSLSGFFGKKNVVLYFYPKDGTPICTMEAKGFRDKIDDFSSLDTVIIGVSKDSVERHANFKAKYSLPFYLVSDENGEMLEKYGVWVEKSMFFKKYMGIERTTFLIDKQGKIMKIWKNVKISGHVDEVLEEIKKNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TR39</accession>
    <name>A0AAV6TR39_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001305">
        <property type="protein sequence ID" value="KAG8174149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TR39"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="7874" checksum="77776BE2382CC277" modified="2024-11-27" version="1">MKNLRSSASTARNFEAPKSTMADDQRLLTGEDRSSDKRKCDDFASLYGLEGSSAGSRNLSDHSGKHPIFPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRU8</accession>
    <name>A0AAV6TRU8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_020774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001262">
        <property type="protein sequence ID" value="KAG8174287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRU8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8174287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="279" mass="31001" checksum="AE6EFBC79D06C428" modified="2024-11-27" version="1">MILVVQDAHSKWIEAVAVRNATTAVTIEKLYEIFARFGFPGCIVSDNGSVFRSAEFDEFIKRNGIRHLFTAPYHPSSNGQAERAVQFVKNRLKKVSNGSLSVRLSRILMNFRRTPLALHGISPAEIMLGRQIRCRLDLVHSPSPNSNALEAPHKSFQNGEEVYIRNYASGERWVPGVINNPIGNKMYSVERPGGLLAERHTDQIRPRVDSPKNNHDLETSVDSPPSVDISDSPPHASEPSCPADAVPPAETLPSPPPAVSTRHSTRTRKPPVRFRDYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TT33</accession>
    <name>A0AAV6TT33_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001136">
        <property type="protein sequence ID" value="KAG8174809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TT33"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="155" mass="17478" checksum="D4167387AD9D4A27" modified="2024-11-27" version="1">MALISDNLSHPKETVVPYIDCILEQFPKEIKDVHIWSDGPSSQFKNRYIAAALHVLKHHHRKKITWNYFASSHGKGPVDGKGPVDGTGGSIKRSVRNAVLKQKYIVTNASEFVSAAHDQPSKINILEITPTDIEMRNKNLYPKHFHKLLSSKTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVR3</accession>
    <name>A0AAV6TVR3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000950">
        <property type="protein sequence ID" value="KAG8175768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVR3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="109" mass="12478" checksum="340AF62F4757A0DE" modified="2024-11-27" version="1">MVWTSILAKKSVVLNCKDFVNVAKRLCTSTTIYHEYRVHNSDIEAEKGMLDAPLENVQAIPNIHKVHCVEIISRNTVKTSLLSEDTIKSKFQFKQEEGEEMEVDKQIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXV7</accession>
    <name>A0AAV6TXV7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_010768</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LSM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000866">
        <property type="protein sequence ID" value="KAG8176556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXV7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000006">
        <property type="entry name" value="Protein LSM14 homolog A isoform b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="5">
        <location>
            <begin position="253"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="6">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="397"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="2">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="3">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8176556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="466" mass="51868" checksum="428978C9C316E1BA" modified="2024-11-27" version="1">MSGGIPYLGSKISLISKSEIRYEGILYTIDTKESTVALAKVTSFGTEDRPTERPVAPRDEVYEYIIFRASDIKDLHVCEPPKPQPTTNSGLPNDPAIVQSSAAVPSAPSNSFSQSGSSFGPIGALPSYQNYASQPNHQHIPQPFSTTTSQRSDSQSETPPPASQQRKSPILDSGSQLSGSSNHVRGEISDRPNAPRQQGKGPPPPRDSRPPNQDRNRAPHTGGQRQQRSPQRGRGGNQRRGRGQGRNRQNFPGRSKDVLDFEGEYDFEQANAEFQELEGKLAKIKIAADQEEIPGESTNSDLAAEAEQPVLIDTSSAEDKNKEEAEWQDENGGDIDDEEAKTFYNKSKSFFDNISCEAVERSKGNAHRHDWRQERKLNVETFGVSANNTWMRRNAWRGRGGYRSRGGYGPRRGGNYGENRGYRNDRQNYGNDRQNNYGDRSYGNRQSNYSNERQNHLPPTAPVQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0K9</accession>
    <name>A0AAV6U0K9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000745">
        <property type="protein sequence ID" value="KAG8177840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0K9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="104" mass="11999" checksum="9AA48AE03E5BD264" modified="2024-11-27" version="1">MIIDWFHICQHHTWFIYLPAKPSLFGICYMVPSGLDDPSHVCVLNNHQKTIHTWPFVDHLNSLSSDLSLSPPDPKRLRYSPTYFRYVTISTNPALVSKLINVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4W9</accession>
    <name>A0AAV6U4W9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_007613</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the fem-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000634">
        <property type="protein sequence ID" value="KAG8179340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4W9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="11" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="13" id="KW-1053">Target membrane</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="16" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="379"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="553"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8179340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="662" mass="76235" checksum="C0B1C764F7DD2049" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5E4</accession>
    <name>A0AAV6U5E4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_011973</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000653">
        <property type="protein sequence ID" value="KAG8179026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5E4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="31"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="192"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8179026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="586" mass="62272" checksum="4E7F188A4992EA90" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5K4</accession>
    <name>A0AAV6U5K4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_026339</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000627">
        <property type="protein sequence ID" value="KAG8179445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5K4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="71"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="150"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8179445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="757" mass="81726" checksum="DF92FA80039CCC27" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6A3</accession>
    <name>A0AAV6U6A3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000645">
        <property type="protein sequence ID" value="KAG8179165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6A3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043843259" description="MD-2-related lipid-recognition domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="2">
        <location>
            <begin position="21"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8179165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="170" mass="19356" checksum="271C671D75A1748D" modified="2024-11-27" version="1">MLIKGLIVLIFVAYAYAEYVPTFDCQNITSAPQSKDVLLQVSDCHATDERCPLYQGRTHSVIVKFKPLKTYSGKIDFRVYGVFEKFSVPYRGRADAYENAHYTDNGEAVSAVGSMIENREIKHTSDFAVSKNYPKVSLKVRFVIIERRTKEMIMCRELPVEIKADPEDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6V9</accession>
    <name>A0AAV6U6V9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000631">
        <property type="protein sequence ID" value="KAG8179375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6V9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10423" checksum="760137A233D848AE" modified="2024-11-27" version="1">MFCGNKVSPCLTGDKDETDEDENDTEDQTGTRSETVGGFWVCYGLGASFGRGFISWTERRQCMDWLVQFGVNHEGEELSFYYVTYIPLRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7B5</accession>
    <name>A0AAV6U7B5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000600">
        <property type="protein sequence ID" value="KAG8179841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7B5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223:SF6">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="387" mass="43269" checksum="99321E5AE9F645A1" modified="2024-11-27" version="1">MATGGIEGNKLENSHNNIQVISVLPSYDGESDSCQHFFGLFSELADLAKWSDQERVTIVKSRLKGNALRYLVDSPKLKNCTFDELRGDFENFFADSQSLTEKHLSFTSLKLLPNEPIRALAHRINTAVSRLMSDMSRSDLQSPVIDRLKLTRFIDALPAEYQLEVLKFAPDGFDKAVELASKIQVALQSTKQLQVNERTLNKVKKPKYLSRSVRIQTVNGSGVRFVSCVELTLKLGGQKLKQVFYVSKDIRGNNLSGIIGCDFIRDNNLSIHLQEQFISLSGLKIPFLGCTERVNTVVVTELPASLVNKQIIGPGETRVLKLRIRQHFVDGTDVLFTPNSKNVHLEIHVAVHKVFCSEFYVIVVNLGCKHMHLNKGMCLGTITPSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7X5</accession>
    <name>A0AAV6U7X5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_020467</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000579">
        <property type="protein sequence ID" value="KAG8180169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7X5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762">
        <property type="entry name" value="ZINC FINGER RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762:SF3">
        <property type="entry name" value="ZINC-FINGER PROTEIN AT 72D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8180169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="823" mass="94934" checksum="6EE9076D28DA5E58" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9W2</accession>
    <name>A0AAV6U9W2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Paramyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000575">
        <property type="protein sequence ID" value="KAG8180226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9W2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42852" checksum="59C77A37517CB74B" modified="2024-11-27" version="1">MSYHHHRPLTGIYGDNYRYGTSLYSPNAMDVEKNYRNSLAKTHLRSDRGDLGLYSFAGSHLHGGTPAADKGSGVGAKGSLRGPNSDLYSPINTTSYGPGYYDHLRATDREPRYRPARPDYLSDEPLTTKASDVWVPSSYQTGPSKLSFEDDLNNRTTTKTTRTSEYWVPLTTHIYNTPYHTYYYKSTPFSSYTYRTADDGLYSYNYVDDFKRSATTTTTTRSKNIDALDLSVTSRNYEKMDYSNHMSKCKDIQIQLDEVNKWVQEAEYKLKSDVIGSRSQMQADLAEVAMIVDDTAKYSEDLHKVIRKQSKQINALNKQYDSVNTTLADISDSLEKSRIRCQTLQSDLSSVQSGLELAMKRKGTERLVTTRFEYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UA93</accession>
    <name>A0AAV6UA93_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_012967</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000549">
        <property type="protein sequence ID" value="KAG8180788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UA93"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043108291" description="Protein kish" evidence="9">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8180788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8047" checksum="EB0394FDC92054A8" modified="2024-11-27" version="1">MSALFNFQSLLTVVLLLICTCAYVRALAPSLLDRNKEGFLGIFWKCARIGERKSPYVAVCCFAMAFTILFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAF9</accession>
    <name>A0AAV6UAF9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ARF7 effector protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000539">
        <property type="protein sequence ID" value="KAG8181015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAF9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12492" checksum="4A4D57AE8BFE1649" modified="2024-11-27" version="1">MFKLAPTAAASKQNSFRTYHQVQQWLNEKNPLKWGWKKVGERLRPIATACPADLEELLSLIACVCKDECVRNCRCRKSGLNCSNICSNCSGLGCDKRDTNIRNEDLEVDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UB39</accession>
    <name>A0AAV6UB39_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_025931</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="JAFNEN010000518">
        <property type="protein sequence ID" value="KAG8181384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UB39"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8181384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="345" mass="38881" checksum="BBACBE5D1B1FF2E8" modified="2024-11-27" version="1">MEQGKYAFVTLATDDSYSKGALVLAHSLRRSETKAKLVVLVTDGVSNAVQDTLNKVFDVVQSVSELDSKDDDNLKLLGRPELGVSFTKIHCWKLTQFSKCVFLDADTLVLKNSDELFEKSELSAAPDIGWPDCFNSGVFVFVPSNETYNGLLKMAADEGSFDGGDQGLLNMYFKDWSTKDISNHLSFIYNMNVNASYTYLPAYNKFGKDVKIVHFLGTQKKPWMYKYDHLTGSVDAPRGNYPLYEYLSFWWKIFNEECSFLDTAILSITQSLTDCSIASVATASSKSSQSTPANTPTDEELQRLDDQRLHDWEKGNIDYLHRDSFENIQRKLDEAINGKSPDKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBB2</accession>
    <name>A0AAV6UBB2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_007479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000560">
        <property type="protein sequence ID" value="KAG8180526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBB2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043439923" evidence="2">
        <location>
            <begin position="29"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8180526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="782" mass="84443" checksum="BB6BB622E5A636ED" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBN2</accession>
    <name>A0AAV6UBN2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_015454</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000515">
        <property type="protein sequence ID" value="KAG8181435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBN2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF403">
        <property type="entry name" value="CYTOCHROME P450 306A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8181435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="58412" checksum="1F5B54FAAD860DB0" modified="2024-11-27" version="1">MSQLQTLIWASVTRARAFEREIFVALVVLVVVYFALGAWKAWRSNLPPGPFGLPIVGYLPFLSLNNPQFDLLKLGKKYGDVFRLKLGSETVIVLHGVEVIKEALSRADFLGRPTQGVLKLFNEGSAFFNGMDVHKWREQRRFVLQSMRDLGLGKSLLEVEILDEIRHFLDNLRVHNGAPMDVKDPLSPSMSNNICSLIFGKRYEYEDPDRVFLDENLDITINAISSTSVAGFFPWILKIPLVSKLFEMERAFNSVNDLMDFFRKEIKKHRSTFDSKNSRDFIDSFIREQSSRKLTDPNTTFTDDTLASNVLDLFAAGSETVRTSILWNLYVACAFPEHQEKVREEILEVMGEREPEYQDMKNMPFTHSFILEVMRWKTIVPLNVPHSTLSDTTIGGYHIPKNATIFTLIWNAHNDPNYWTRPESFIPDRFITKDGKSVSRPAHFMPFSMGKRVCPGEPMAMMELFLYFTSIIQKFQLVFPAGYKPTYEAAMGGTYRLEPYKIRFLARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCU3</accession>
    <name>A0AAV6UCU3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_016594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lectin involved in innate immunity. Agglutinates all types of human erythrocytes, Gram-positive and Gram-negative bacteria. Has a stronger agglutinating activity towards Gram-negative bacteria than towards Gram-positive bacteria. Specifically recognizes acetyl group-containing substances on agglutinated cells. The hemagglutinating activity was inhibited by EDTA, acetyl group-containing mono- and disaccharides, N-acetyl derivatives of amino acids, other acetyl group-containing substances, propionamide and benzamide. Enhances the antimicrobial activity of big defensin against Gram-positive bacteria but not against Gram-negative bacteria.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000536">
        <property type="protein sequence ID" value="KAG8181081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCU3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043608171" description="Fibrinogen C-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="5">
        <location>
            <begin position="57"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8181081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="298" mass="33964" checksum="14BAB27792AACA61" modified="2024-11-27" version="1">MNERRADFIILFMLLYVTANAQEKQTLDCGAKITTQSYLEVAGEMIKKAKDTNSNCPSQSAVTIDCETLLKSGNTKSKVYTVWPKSRVLDGKPVEVYCDMETDGGGWTVIQRRGNYLGAKDHFFQDWEAYKNGFGNVEEDFWLGNDNIFALTNQRLYSLRIDLRDVEGNKTYAAYDSFWIDDDNHKYTLHVRGYSGDAGDSLIASHNNQKFSTKDQDHDTDADTNCAQSYKGGWWYSACHTSNLNGLYPRGKHESFADGVVWLSWKGYHESMDTVEIKIRPKNFRKTVQTVDLDVTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF54</accession>
    <name>A0AAV6UF54_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fukutin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_018091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000434">
        <property type="protein sequence ID" value="KAG8183045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF54"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045587">
        <property type="entry name" value="FKTN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19737">
        <property type="entry name" value="FKTN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ribitol-5-phosphate transferase FKTN N-terminal" evidence="6">
        <location>
            <begin position="30"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="5">
        <location>
            <begin position="278"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8183045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="52312" checksum="0CF8264C2AC3B9E4" modified="2024-11-27" version="1">MQKCKLLSIACCFSVCVLAVQVLILKTLLQKEEKIEIGADISHEFISTVLSLSFKHNVPLFIIDPKFFRRIHKASESDEEKCYFLCSSEKMLHLATIGPVSSQLQKNAFIEAVEGDSYKVWQFSGPDPVLLQHGLNSPVPLHYLLSDKLIIIHISIFYERPSKFWWTGGYHFKSQDLRDFYIKGITDEDLHLITKPAAFEKVEIHSATINKVKVFVPVQQEVFLKYPSNTNFIECNYTQARKFHETYGRDESDSAEIFRSRALKLLTKATRLLDQLQVPFWLSSGTCLGFYRECGFISHSKDVDIGIWIKDYKPQIVAAFSTHDLPLTHSFGKVEDSLELSFIDGELKLDMFFFYEEDTYVWNGGTQARTGKKFKYMFPKFHLCWTEFLELKVRIPCETEDYIKANYGPKWFEPIKVWDWKASPPNVLPNGQWPVEEWPEVIQLLPLPEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFM1</accession>
    <name>A0AAV6UFM1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000427">
        <property type="protein sequence ID" value="KAG8183217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFM1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="194" mass="21584" checksum="B008CB1972F9CFF5" modified="2024-11-27" version="1">MSRGQRCTSPIDTPSFVAKNSFVMPFIGCLEKDKARDSKNSSNEAMMALSDFCLITYYVNNNSPDSVEATLKINSTMLFAVVVACLVCCSFVGAQEECKDQMKIMKEAFGKNIKDWPCFEKFNLKEFMCSEDGSDETEKMEEFKTWKSKQSEADQAEIETCVGELIAKTMADCGDQLTEDCKKIILGKLGGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIH4</accession>
    <name>A0AAV6UIH4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein vein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_024417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000431">
        <property type="protein sequence ID" value="KAG8183106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIH4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000612">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="13"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="115"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8183106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18803" checksum="5CED8B61C1FC4CBD" modified="2024-11-27" version="1">MSERELPWAAKAPSVKGLNDDVRVDTHSKLKLKCRISGNPPPRVIWFKNGLRLKADGRIKLRSKRRYSHLVIQRVSLEDAGHYKCIAKNILGNATAFANVITTTATTESPFWHLRKDPCPEKNFCLNGGVCIYFKVVKEYACECADGYGGQRCETKVISTLSIDFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJ81</accession>
    <name>A0AAV6UJ81_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000419">
        <property type="protein sequence ID" value="KAG8183376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJ81"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="199" mass="22606" checksum="B8114B9FB50F152C" modified="2024-11-27" version="1">MTRVFQVRVGSTLSRDFYQREGVPQGSVLSVVFILMINDIVRQLLPTVKGTLFVDDFQISCASANISTVERQLQIAIHNILDWTNNNDFVIFNQKTICMHFCRKRGLHPDPEIILNGVALPVRSETKFLGIIFDMKLTFLPHIQHPRQKCNKSLNILKVLFSTTYGADTTSMLRIYRALIRSKLEYGVAAYGSARKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJF6</accession>
    <name>A0AAV6UJF6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000374">
        <property type="protein sequence ID" value="KAG8184414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJF6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9617" checksum="A055C3F5B75602BB" modified="2024-11-27" version="1">MPRIYSSSGEIRFKKDPSIIDYEAAYTTWCRLQLPGTESFSRPRVVAGSCLVIPSIIPVIRSGDPDLTTRNMWYVVVATLGLVKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UL89</accession>
    <name>A0AAV6UL89_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000378">
        <property type="protein sequence ID" value="KAG8184310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UL89"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043361260" evidence="1">
        <location>
            <begin position="21"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="642" mass="70762" checksum="512A1FC961C1E2B4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UP93</accession>
    <name>A0AAV6UP93_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_027669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000317">
        <property type="protein sequence ID" value="KAG8185999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UP93"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8185999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="910" mass="104670" checksum="9055DF6243699394" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQI6</accession>
    <name>A0AAV6UQI6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase SHPRH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_028905</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000321">
        <property type="protein sequence ID" value="KAG8185906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18070">
        <property type="entry name" value="DEXQc_SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000013">
        <property type="entry name" value="E3 ubiquitin-protein ligase SHPRH isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048686">
        <property type="entry name" value="SHPRH_helical_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048695">
        <property type="entry name" value="SHPRH_helical_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21325">
        <property type="entry name" value="SHPRH_helical-1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21324">
        <property type="entry name" value="SHPRH_helical-2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="1191"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1277"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1028"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8185906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1451" mass="168301" checksum="5F3DA958913838EE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQX0</accession>
    <name>A0AAV6UQX0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LSM12 anticodon-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_022718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LSM12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000311">
        <property type="protein sequence ID" value="KAG8186129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQX0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01735">
        <property type="entry name" value="LSm12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048478">
        <property type="entry name" value="LSM12_LSM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21166">
        <property type="entry name" value="LSM12_LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="AD" evidence="2">
        <location>
            <begin position="89"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8186129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22329" checksum="6EE6E459C19A10DF" modified="2024-11-27" version="1">MKYTMAEDAEEFNLFSVGTIVSCKTCFGDDFEGEVTAFDYQTKILFLKCPSKSGKANVHDMRMINLDFVEDVVIKKEVTNPVNGTQSLMPLNIEKLSGRAKQHVKERQRLVNALTSGVSNDGVKLFLAITKTIAEVTWQGKNIVVMNQVTIQPPYHPENCKAIGKGDGDAVNHVKRIVDKYFKDQAQAQSPQPQSKPHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URF1</accession>
    <name>A0AAV6URF1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_012009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000310">
        <property type="protein sequence ID" value="KAG8186185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URF1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8186185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="339" mass="38794" checksum="A7A4FC0A2BADB880" modified="2024-11-27" version="1">MTGCSAIGCTNRTEHGFSLKRFPSDPHRRKLWALKVKRKNWVPSINSYICEEHFDKDQFTDFEKKKLKKDAVPTLFNFTTVQRKKPACRPPPKIIKLKSTDCDVNKKDGISQSDGVSKTDDNVNTVDNASKTDDFVNKVDNASKADDNVNMVNNDCKTDDGDSKTDDVSKDLIIASLHKNLKECNKRIVQLQEKNFRLKVKLKRETHTSAGLRFQAKKLKEEKKISFFGDDQNAALKRKSMAYVKWSDETIEKALTLKAACGTKGYECILNLGFPFPSMRTLQRRLESNDPVQEDDESNNYLSSEHDDELDDHGTSEDDWDELNDHLALEHLDDNYNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URS1</accession>
    <name>A0AAV6URS1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000317">
        <property type="protein sequence ID" value="KAG8185986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URS1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="497" mass="56145" checksum="D78875288AA43165" modified="2024-11-27" version="1">MGSVADPSTTARWSAAMKSDKIVPQWSLKQSCLCTVKDSILGWSRGRKNSVCSQSNNENPFLEYPIDLKHELLNHLLRLKPTGRELLKAAELLVTSGIPSFDLSALDDCKFSDVHGILDILIRTGGCLKELILAGQWMYHETSSTLLQELLRSIPNLRYLKLQHTTKDGHELEVALKHCPQLKRLEILHPSVDESEIDNLVRAIEEDPESYSFAKNTLTEMRLPSSVTGKSILQLLKALPNLEYISCTYLDQIIDELEDIEDAPYWKQRASSLLGIHVSQPVCEDTPGLLVDWFPNLEEVSLEVQEGMELQPLAKLTKLKSLELKNSHTISLSYMDEVLPLLTACGQNLLSLSLERFDVIDLTKTATYCPNLRSFSAQWFTILSTTMGRGSKNLNPFLNLRYLRLRPRVNRKVTPEACEILLTNSQCLKHLEFYCSYGLTDALVTKLLKTNQFNNLRTLLLRHGHGLSSNGVLQITRSALNLRVWDVGMIYTKPINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URT1</accession>
    <name>A0AAV6URT1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial potassium channel ATP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-binding cassette sub-family B member 8, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Mitochondrial sulfonylurea-receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_009218</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000300">
        <property type="protein sequence ID" value="KAG8186459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URT1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18574">
        <property type="entry name" value="ABC_6TM_ABCB8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000016">
        <property type="entry name" value="ATP-binding cassette sub-family B member 8, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000403">
        <property type="entry name" value="ATP-binding cassette sub-family B member 8, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF17">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="20">
        <location>
            <begin position="136"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="19">
        <location>
            <begin position="462"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8186459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="713" mass="78977" checksum="E4AD80F76A528D41" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USC9</accession>
    <name>A0AAV6USC9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000278">
        <property type="protein sequence ID" value="KAG8187109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USC9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="11079" checksum="482CA8C0D0B84831" modified="2024-11-27" version="1">MDEEEFLLLATAVCLYAKQRRPKRKWVKQWLLNRRQHTHLNLLQELRLEPSDWRNYLRLDEKAYFQLLRLVTPMIKKKRYSHETVHYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU28</accession>
    <name>A0AAV6UU28_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000264">
        <property type="protein sequence ID" value="KAG8187654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU28"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="8950" checksum="D747209847BE49E2" modified="2024-11-27" version="1">MGNRGAKEHVQERTGDSPKCGKKRTAGFTRRLPAARGARTWVEHPPQRIIGVRMPYLGVKWQLERILPSQGVRTDPEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UV56</accession>
    <name>A0AAV6UV56_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">NAD(P) transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nicotinamide nucleotide transhydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">JTE90_019463</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000247">
        <property type="protein sequence ID" value="KAG8188185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UV56"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000028">
        <property type="entry name" value="NAD(P) transhydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000002">
        <property type="entry name" value="NAD(P) transhydrogenase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="775"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="853"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="26">
        <location>
            <begin position="74"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="25">
        <location>
            <begin position="214"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAG8188185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1082" mass="113306" checksum="E35A16914EC1B01A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UW25</accession>
    <name>A0AAV6UW25_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000243">
        <property type="protein sequence ID" value="KAG8188299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UW25"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="108" mass="12529" checksum="92285B6A3892D643" modified="2024-11-27" version="1">MYGFPPDFKENFGKSRKSSSMQQKCYRESIAGKIVSSAPPEVSHVLRKNRKTRKRRPAVCWTPTRISSRIGIWLMGCLNRNSESSLDRNLYWLGRSREDLGSYKRTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UW38</accession>
    <name>A0AAV6UW38_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_009885</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000251">
        <property type="protein sequence ID" value="KAG8188008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070776">
        <property type="term" value="C:MOZ/MORF histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1867" mass="208482" checksum="2E0C54DF937E4E5E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWB0</accession>
    <name>A0AAV6UWB0_9ARAC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
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            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="entry name" value="GAG-LIKE PROTEIN"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAG8187958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="317" mass="36518" checksum="F3C8B30D6680E55A" modified="2024-11-27" version="1">MQLERRFDKNTELADRYSQHMQEYIDLKHMTEVPYSQQQLKPQDNGYPGFYLPHHPVFKESTTTSLRVVYNASQNSANGISLNDSLLTGPNIQEKMANILLRWRLYKVAFTADITKIDNVEDALTKQKQVTTALERSGFTLRKWASNCTPVLEGIPQESQQVLNIKEIYNDRHVKTLAQNPADLATRGVTPVDLQARSLWWNGPEWLAETQSQWPKNHCSEPITLEEKKVKSIHVSSNEEFDLMTKFSSLSKLTRVTAYILRFSTNCKVPKSERNLSYLTAEELEASFRSLISIAQNQDFHKDIESLRNKKTLVPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWB4</accession>
    <name>A0AAV6UWB4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase 1 regulatory subunit 10</fullName>
        </recommendedName>
    </protein>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000239">
        <property type="protein sequence ID" value="KAG8188389.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, CCCH-type"/>
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    </dbReference>
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        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
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        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
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        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="13">
        <location>
            <begin position="103"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="828"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="828"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="180"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="376"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="193"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="420"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8188389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="860" mass="97039" checksum="B054C16FD5B6382F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWM0</accession>
    <name>A0AAV6UWM0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000231">
        <property type="protein sequence ID" value="KAG8188772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWM0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043921975" evidence="1">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="132" mass="15158" checksum="1526824A5EABAFE5" modified="2024-11-27" version="1">MRLLTWLVVALFALQCINTEVVYGGDTLPTPNVLERKKYKVELKHIEKRSLGPYRFPFGRPIRFPGNRVGRAVFISNKSFVQRRDAYFSRGIELTEIPPSLDTRSFPERDAKNAWHDKRLISPGLSLGISVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWN1</accession>
    <name>A0AAV6UWN1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000237">
        <property type="protein sequence ID" value="KAG8188524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWN1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF20">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="2">
        <location>
            <begin position="573"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8188524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="670" mass="74207" checksum="13C686E92021BD9D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXY2</accession>
    <name>A0AAV6UXY2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000233">
        <property type="protein sequence ID" value="KAG8188702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXY2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="82" mass="9374" checksum="234A4B3FB43DDB6B" modified="2024-11-27" version="1">MAKADDIRLWYKSLPDKPRQISTLHISLIYQGMRPHHPLYLCPGQCIKSYSITPGHPGILQICNHVLVVYHARDNAHICPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYD8</accession>
    <name>A0AAV6UYD8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Thyroglobulin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_012519</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000215">
        <property type="protein sequence ID" value="KAG8189447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYD8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16234">
        <property type="entry name" value="EFh_SPARC_SMOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000004">
        <property type="entry name" value="SPARC-related modular calcium-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF30">
        <property type="entry name" value="FI05255P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thyroglobulin type-1" evidence="10">
        <location>
            <begin position="68"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8189447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="292" mass="33414" checksum="3F21AF15A21F2193" modified="2024-11-27" version="1">MSLNSEEQVNGLIGFLEDSPKHDEEPTEATPQMRPDQWSRDAMPRLRHDGHSSTKTEDSSEEDSKEELQDCKTARRTAMDSHRADPAAGIYIPECTPGGLYVRAQCHRSPQYCWCVHPRTGRPIKGTATQGYKPDCDTARQKNFKGCSIHKKQEFLDELVQNFIKEMQEDAKNKSLSIDTPTPEKAARWKFASIDANSNSVLDKREWKVFKKEWRSFQQRSSGGGGAGEKRKQRLRKCWRNLPRYCDENDNHKITVDEWLACTSVSRDSKGALPRNQPRRGKNPFSTILKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZK3</accession>
    <name>A0AAV6UZK3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000200">
        <property type="protein sequence ID" value="KAG8189897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZK3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="185" mass="21647" checksum="DD447B3093169DE6" modified="2024-11-27" version="1">MCTTWCFRIGETIGQIGGLDLDKGGVESGQREEDDLSGQEKLLPETKINKMVMQGEKRTTKSERDDEIREENREPHHRSIVQDLVPSKRHWRAQTRHRRGSADRPVPEPHHRSNVQDLVPLRRYRRAQARHHRGSADSPVPEPHHRSNVQDLVPSRRRWKSQTQHWRSVRSLPTTHKEPRTGQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZZ6</accession>
    <name>A0AAV6UZZ6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_023019</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000195">
        <property type="protein sequence ID" value="KAG8190047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZZ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000033">
        <property type="entry name" value="Phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040724">
        <property type="entry name" value="PheRS_DBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040586">
        <property type="entry name" value="PheRS_DBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18552">
        <property type="entry name" value="PheRS_DBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18554">
        <property type="entry name" value="PheRS_DBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="228"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8190047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="496" mass="56845" checksum="516A9B81377FEDEF" modified="2024-11-27" version="1">MTELTEEILLYLKDNGDCAVDSLRLAETFQIDHQKIVGAVKSLQSAGNLINAEQQDLKYWKLTGEGDKVAENGSYEALVFYAIPPEGISQKQLMKSVPQSNVGFSKAMSAGWIYIEKKEGDTMAFRKVDNIIDEVQNNLMKIQNSRENEVAQNTKLELKKRKLLQEMTIKSYKIEKGPDFTTSHIKQETDLTPEMISSVSWKDKTFKPYNFAALGIVPDGGHRHPLMKVRAEFRQIFLEMGFTEMPANNYIESSFWNFDALFQPQQHPARDAHDTFFVSDPQFADDFPMDYLQRVKKVHSVGGYGSQGYNCDWKIEEARKNLLRTHTTAVSARMLYALAQQEKFTPAKYFSIDRVFRNETLDATHLAEFHQIEGVLTDYNLTLGDLIGVLHQFFSKLGIKQLRFKPAYNPYTEPSMEIFSYHEGLKKWVEIGNSGMFRPEMLRPMGLPENVTVLGFGLSVERPTMIKYKIDNIRELVGHKLNLNMVNSNPICRLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1T6</accession>
    <name>A0AAV6V1T6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_009097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000199">
        <property type="protein sequence ID" value="KAG8189958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1T6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="115"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8189958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="283" mass="33380" checksum="DAA16E00C083F20D" modified="2024-11-27" version="1">MTIEKIPDMEVDVEKNVTDDQLSVKESILDSVAKGQGFFKSQQVGEKDLTFSEKRDIAADLLSKNVPLFLQRYWKFIKLEDTSYFDSLDCYEVKFYVDEIKKFRDPRKNKNSVKNRRFGALRKMIKEGAYFSDEEMKSRNPFMFDQFIGQHLSESERVAAYKSQHTDEKFSNFLLGQVERNYANTLYEQQKSTDEAIEEEEDDDDDKSVESDESELEDEPEQKQPVTPDEKSRLRSEFTNMMYESFMAGEDKEFDYSCVDYNEEFDPAEKDVDAEEKYFNEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1Y3</accession>
    <name>A0AAV6V1Y3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_023024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TMEM104 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000195">
        <property type="protein sequence ID" value="KAG8190052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1Y3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="532"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="188"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8190052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="565" mass="62556" checksum="FC16AE3491E41D9A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5F3</accession>
    <name>A0AAV6V5F3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_002545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000170">
        <property type="protein sequence ID" value="KAG8190938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5F3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF495">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 69D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="127"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="303"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8190938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="402" mass="46461" checksum="5E7E0496C797B942" modified="2024-11-27" version="1">MWSDFLSPGQPSWLLRFIKRVNEHYSLDKGPLLVHCSEGVGRSGVYVAIDSLTEQLDSEGIVDIFSFVTQLRYHRSNLIRTIDEYMFVYRALMEHAQFGDTELELHHLRDHYELLKGKVRDNCRTGLEVEFEKLNDVCEESKTYCVGAWDINKCKNRYECIIPYDMNRVILLPSNADQSSYINASHIQGYYRSLSFIITQDPLPQTIWDFWRMVREQRITTIVMLSDLGPDLNKCPQYWPDENQEVVYETVRVKLKCTTHTSHYILRQFVVTDMEDEGKHVLSQFQLTNWCPGGGGGVPDNLSSLIVAIEHVQQAHNSHLSTGPITVHCSGGGDRSGIYVALSDLIEQARCDERVDVFQTTKYARAQRHCLLQTLEQYDFLYRGLIHYVERYNLCNLGDTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6M9</accession>
    <name>A0AAV6V6M9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6M9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7975" checksum="5C536B6A2074CABE" modified="2024-11-27" version="1">MDGVTDDSFFSHSYFGGIPLAIFMSVASDTSRQCFLFFSRKSDEESKGDNFFSRAKGNKFENERSLEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8Z6</accession>
    <name>A0AAV6V8Z6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_005531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000127">
        <property type="protein sequence ID" value="KAG8193180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8Z6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="184" mass="19747" checksum="0DD14558AC17A146" modified="2024-11-27" version="1">MTPQGRTQQTTLSPTLVRIVCVTLTFVSLGCALLGLGLTCFFFESSAPCPDRLTVGAFGVAGGLLGLSLILFVVVCRKKNRLNKETLLEDLPLGVIGGAQYKKKMSGDAPPKLSSADLEEAPQAISNDGEEHFDMTQKSADVSYWIQQQKSEVPSTSSSFPLDHTDGATHHQSENEDDGEMTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V956</accession>
    <name>A0AAV6V956_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_005587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000127">
        <property type="protein sequence ID" value="KAG8193240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V956"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="46"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8193240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="282" mass="32390" checksum="8B1B925574A3CC93" modified="2024-11-27" version="1">MEPNNVNASHNVTHVIVTKGPPVTSKVRRLVSDKLKIAKAEFDYMLEHGICRPSSSPWSSTLHLVKKKDGGWRPCGDYRALNAATLPDRYPIPHLHDFTHQLEGTTVYSTLDLHRAYHQIPMEPSDIEKTAIGTPFGLFEFPLMTFGLRNAAQTFQRFMHSVLRGLEFCFVYLDDILIASRSKEEHLSHLKIVFEKLQQFGLTLNLSKCHFAQPEVNFVGHIVSQKGIRPTEEKVKVIEDFEKPKTVKQLRRYLGILNFYRRFIPQAAHHQASLNDYLKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V981</accession>
    <name>A0AAV6V981_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_002113</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000141">
        <property type="protein sequence ID" value="KAG8192288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V981"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052454">
        <property type="entry name" value="TMX_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107">
        <property type="entry name" value="DUMPY: SHORTER THAN WILD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8192288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="225" mass="26208" checksum="3B23A4E8F2A40EF0" modified="2024-11-27" version="1">MLHRDVKRIIVFFTFYTCSLFILKAVRTQEQVKVKKPEEVPDLTVELFDNKWDQIQKGQWLIGFFDKETKESLRLEEDFKVFALKGKERDINVARVFAPKNPGLYVRFLVTVFPKVFYVKNGVAHEVKQPTRENLIGLIKDNRWKELKPVNFLSNPFSVQMSLLSHLFVHAVNLYNYEDGIVQKFVPYSSATDVAFALTFIVVGTFLGLDIKDNRSLKPVQLFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9U0</accession>
    <name>A0AAV6V9U0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucosidase II beta subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_005555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000127">
        <property type="protein sequence ID" value="KAG8193207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9U0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosidase II beta subunit N-terminal" evidence="2">
        <location>
            <begin position="82"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="205" mass="23690" checksum="5CE5E26BA8C0272F" modified="2024-11-27" version="1">MNIFRYRYFFRPKRCIIFTTIVIAFFLMYQLFSVGQLGKELSRRGPRSRLQTNFRSYEKADGFMMPKKSDKEVLPEQPEVDSLNFVIGVLSSSQELYKPTVRNTFRCLRSGEEIDYSFLNDNYCDCTDFSDEPSTSACNVGKFYCTHQSEHNVNSIVSYKVNDGVCDCCDGSDEWLHIKPPEHSQVPAIKQKGIYQVPCPMKCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VA23</accession>
    <name>A0AAV6VA23_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000132">
        <property type="protein sequence ID" value="KAG8193052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VA23"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="110"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="294" mass="34474" checksum="93BCFD30F5FD1D8B" modified="2024-11-27" version="1">MVIDKSKVTEKSTMIEKSNSLLPFDAYFLTEKYVHKARVELGETEQVRKSTMKQLRELATNEQSITYHITDEDLIKFLRGRKFNVQRALALMKKYSNYKKKQLHYFSNMKHDVLSKLVKDRVFEFLPYRCLDGCAVLVFNLNNWNPSEIHIDDLIRCLSLFFYHSINDPMTQVNGYKVVFDVKSPGLKHLRYATPYYMFLLYYGTQECFPGRFKGIHIINVSMAFKAAWAILTNFVSDKIQRRLVLHKGTETLLDYFPEKMLPVEFGGSLQSNNSMAFFEDGMLPENLERLAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VA24</accession>
    <name>A0AAV6VA24_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_003770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPEB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000125">
        <property type="protein sequence ID" value="KAG8193282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VA24"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12723">
        <property type="entry name" value="RRM1_CPEB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12725">
        <property type="entry name" value="RRM2_CPEB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000054">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000086">
        <property type="entry name" value="Putative Cytoplasmic polyadenylation element-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032292">
        <property type="entry name" value="CEBP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034977">
        <property type="entry name" value="CPEB1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF9">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16368">
        <property type="entry name" value="CEBP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="306"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8193282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="546" mass="60364" checksum="F9DF36A4D3254929" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAF2</accession>
    <name>A0AAV6VAF2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_009746</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAF2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF71">
        <property type="entry name" value="PROTEIN TRAPPED IN ENDODERM-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="335"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8192723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41702" checksum="ABE05CA229FA0C91" modified="2024-11-27" version="1">MEEEVLHVIDGLYNPTNMSDPSHVLPNRPSTLTCIVAVFCCIVFIIVGCVGNLLTIIALTRCNKLRNATTAFVVSLAVADFLFCAFCLPLTATRYVYKEWILGDELCTLFPFFFYGNVAASLMSMTAITFNRFVLINCYQVYNRVYSRTNVVLMLALCWGFSYLILVPTLAGRWGRFGYNPASFSCTILRTAEFGSPRKFLFLFGFLLPTATIVVCYSCIFYKVRTSALNLMSHNNSSNGNKRTSRLWPKRREEIRVTLTMLACFCTFQVCFLPLMVMNVFEDSIRYPVLHTLASILAWMSSCTNSFIYVLLNKHYRDAYGQLLCLLKHTGLTPRSTSCEGASGASRTTHLRGEDKSNQSQLSVSRDLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBW2</accession>
    <name>A0AAV6VBW2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair protein SWI5 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein SAE3 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_000982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the swi5-sfr1 complex, a complex required for double-strand break repair via homologous recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000108">
        <property type="protein sequence ID" value="KAG8194144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBW2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8194144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="124" mass="14509" checksum="1C3389750D49122A" modified="2024-11-27" version="1">MNNIGTPKPNSRRRSKFVSPATSYKSPLLNKPVTKVVFDPSRASLEELKQQAVELWQKNEEMKNEIEILKNQGFEEEQLKWYIDKLHEYNDIKDIAQNIMGRIAVSERTTIRKIHEEFGMTDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCT4</accession>
    <name>A0AAV6VCT4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyanocobalamin reductase (cyanide-eliminating)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_005098</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MMACHC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000121">
        <property type="protein sequence ID" value="KAG8193451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCT4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033787">
        <property type="term" value="F:cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12959">
        <property type="entry name" value="MMACHC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032037">
        <property type="entry name" value="MMACHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31457:SF2">
        <property type="entry name" value="CYANOCOBALAMIN REDUCTASE _ ALKYLCOBALAMIN DEALKYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31457">
        <property type="entry name" value="METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE C PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16690">
        <property type="entry name" value="MMACHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8193451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="253" mass="29696" checksum="743C75E2AB6D6C6C" modified="2024-11-27" version="1">MTQVNSDILNEVSSELEQTFGSLGFEFHPFKVGWYNAFVQPAFKLNYDEDTVAFVILSLPKMFENAFVPFVQEKHKQLCSVKDPIDECMLHYLSDIYKMFAQFSVKVIHDFELHPNRRPKVIMQSAAHASGAAYFYNPNSVYLDFTNEKRKMYGVCIHPRYGGWFAIRAVAIFENLKCPNLKRTPPPNIVPSIEDQTKLLQLYNFSWKDWRFRDIIEAKEKYSDLQMKYFSTPPGYRLEVISEILNEYDHEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VE27</accession>
    <name>A0AAV6VE27_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000098">
        <property type="protein sequence ID" value="KAG8194797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2199"/>
            <end position="2551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2199"/>
            <end position="2210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2211"/>
            <end position="2220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2239"/>
            <end position="2254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2270"/>
            <end position="2282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2290"/>
            <end position="2303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2309"/>
            <end position="2324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2341"/>
            <end position="2358"/>
        </location>
    </feature>
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        <location>
            <begin position="2361"/>
            <end position="2373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="2397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2437"/>
            <end position="2460"/>
        </location>
    </feature>
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        <location>
            <begin position="2461"/>
            <end position="2486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2504"/>
            <end position="2531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2551" mass="286299" checksum="BE4458C5D9397D0E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">ribonucleoside-diphosphate reductase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">JTE90_029636</name>
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        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Araneomorphae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000094">
        <property type="protein sequence ID" value="KAG8195057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000827092">
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    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBORED_SMALL"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="394" mass="45196" checksum="AAB6FA8CCBB5D662" modified="2024-11-27" version="1">MSSISVLNENAKNKRNESLTNKENKNITKSPRKSIGKSPRKLAPLSPSTLTIPESAVRNLSLESPRKKTFLEDEPLLRENPRRFVVFPIVYPDIWRMYKKAEASFWTVEEVDLSKDNVDWEGKLKDDERHFVSHILAFFAASDGIVNENLVERFSQEVQVTEARCFYGFQIAIENVHSEMYSLLIDTYIKDKAEREKLFNAVETLPCVKRKADWALNWIASPDASFGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFSHIVHKPSQERVTHIITDAVKIEQEFLTDALPVALIGMNCKLMNQYIEFVADRLLVELGCDKVYNVENPFDFMEHISLEGKTNFFEKKVGEYQKCGVMSNKEDHKFTLDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VES7</accession>
    <name>A0AAV6VES7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">JTE90_008179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000095">
        <property type="protein sequence ID" value="KAG8195007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATHOOK"/>
    </dbReference>
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        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
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        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
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        <location>
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            <end position="34"/>
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            <end position="78"/>
        </location>
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        <location>
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            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8195007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="9305" checksum="A6995804D3B6C316" modified="2024-11-27" version="1">MSDSEGAGDSKTRGRGRPKKSEASKDSGTDEPKAKRGRGRPKGGVKKAKKTTSSAGSSKRGRGRPPKKSEPKESKKDSDEDSGDDKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGG2</accession>
    <name>A0AAV6VGG2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000092">
        <property type="protein sequence ID" value="KAG8195148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGG2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9179" checksum="1B5190E7D529996C" modified="2024-11-27" version="1">MDTRGGGYGISIKREAVKDNGYLASLISVRGLNEGCHWAICDVPFGVEGMACLDGLSREVVDELFQKNWIVRPISHGPLSRGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VH86</accession>
    <name>A0AAV6VH86_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000075">
        <property type="protein sequence ID" value="KAG8196034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VH86"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="91"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="200" mass="23542" checksum="6835296A6C790335" modified="2024-11-27" version="1">MAEFDDENYANSDSECDELIGLYADDDDACVELDEEPADFNNEIQDTEEETEEEKIQWKTAEDNKHFKLKILKCEDPTPGPIANIKNFTELDLFHQMFDDNIMKTLVVETNRYAEETINIRKSATPTTKNWKQVDEKELLQFFGLVLLMGLIEKDEISDYWSTDELTETPIFSKTMSRDRFLLILRYLHFSDNSKKLKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIV4</accession>
    <name>A0AAV6VIV4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000069">
        <property type="protein sequence ID" value="KAG8196477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIV4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043697827" description="Secreted protein" evidence="1">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="10143" checksum="992B2092167BBAEE" modified="2024-11-27" version="1">MLFTVKPTLSVRNHAKVFLILAAMIHCLTDTTTTQPQRWMSTSGNNRELHHFEGEANFQRHPTLPSLPEGHIHLQAELLTRLWLPSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJT3</accession>
    <name>A0AAV6VJT3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein Dr1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Down-regulator of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Negative cofactor 2-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_007894</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NC2 beta/DR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJT3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8196164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="166" mass="19204" checksum="2CAD7121BE05460A" modified="2024-11-27" version="1">MAETDEDLTIPRAAMNKMIKELLPHIRVANDARELILNCCTEFIHHISTEANDICNKLQKKTISAEHVLSALEALGFNSYKEEAEAVLKDCKAMAAKRRRQSTRLENLGIPEEELLRQQQELFAKARQEQAELEQQEWLQMQQAAQHQLQLQKQNSQTDQDEDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VK75</accession>
    <name>A0AAV6VK75_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_028930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000075">
        <property type="protein sequence ID" value="KAG8195956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VK75"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF14">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="11" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8195956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="60074" checksum="CD02719B5E96D54D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLX8</accession>
    <name>A0AAV6VLX8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_027632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLX8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8196929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="140" mass="16325" checksum="10DD2491A22A4420" modified="2024-11-27" version="1">MENGDVKPVMFASRTLNSSERNYSQIEREAIAIIFAVKKFHKFLMGHKFVLQTDHKPLTAIFGEKRGIPPIAAARMQRWAIILSAYQYEIQFVKGNSISHADALSRIPLPETVEEVSCFSMCDEFNHFIYFFFRQWKVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMU5</accession>
    <name>A0AAV6VMU5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000046">
        <property type="protein sequence ID" value="KAG8197984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMU5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="160" mass="17725" checksum="899191AD5D29FCE8" modified="2024-11-27" version="1">MRGSIDPRMRTDERREGMEEDAGFKWSGEEHVAVGMDGAKPEARQSFTYSIEYLLKKDTCPKPVPKSPLDVPMFSSIQTESKSFPCPQTDFSSPAFLSFVPQKLSLLFPCSSLPSQSLGNEFPSCPGKQPADCSAHLNCTCGYQCHAARWAEQLHFAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP09</accession>
    <name>A0AAV6VP09_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000051">
        <property type="protein sequence ID" value="KAG8197768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP09"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10677" checksum="0C4700FD827D9EC3" modified="2024-11-27" version="1">MYGACRQLPTLPNCFVRKLPNFLVMVCSNHRYLAIGYLWIIYHLFYAIGDADIVIVKVTACPARGLSLACDVWLRRPRRKRDHGGWDQALLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP10</accession>
    <name>A0AAV6VP10_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000042">
        <property type="protein sequence ID" value="KAG8198220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP10"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13468" checksum="105AFFB321B99D54" modified="2024-11-27" version="1">MKFLGTEKNRTTAYNPASNGQVERFHRQLKQAIRCQATERWVEVLPSVLLGIRSCFKEDLGASSAELVYGTTLRLPGEFFRSSSSSTTPTHAELNIKRNTLSALNHDLTCEEWSSNETCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQ52</accession>
    <name>A0AAV6VQ52_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_021591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQ52"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="4"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="478"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8198343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="712" mass="79361" checksum="A7EB4BB6374F0B2F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQA7</accession>
    <name>A0AAV6VQA7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000035">
        <property type="protein sequence ID" value="KAG8198799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQA7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032072">
        <property type="entry name" value="DUF4807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36693">
        <property type="entry name" value="GH02722P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36693:SF1">
        <property type="entry name" value="GH02722P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16065">
        <property type="entry name" value="DUF4807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="151" mass="17419" checksum="B0DD3827D3531DCD" modified="2024-11-27" version="1">MQVLDLSWNKRLQILVNERCELENAMAWLSTLGGAFSALGDTYIDCAEKAGLISIKQFQLALRIGDLLTICRCKIYLAMSLLQRGYYRKTKNMVRELYNFSIGPEGSKDFRLKNMCIAVWNRLKYVLSENRKCKSSSSGKMTFLTYSRNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VR47</accession>
    <name>A0AAV6VR47_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter NIPA2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_015985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000030">
        <property type="protein sequence ID" value="KAG8199154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VR47"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8199154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="42960" checksum="F9C37744C7877722" modified="2024-11-27" version="1">MSTPNFPMQVPHVSYNFYVGLGLAISSSIFIGASFVIKKKGLLKIGGQGQTRAGLGGYGYLKEWIWWAGLLSMGIGESANFAAYAFAPASLVTPLGCLSVLVSAILSSKYLGERLNLLGKIGCFLCVVGSTIIVLHSPKEGTVDSVEKLGELLLDTGFVLYLIFVGFSSFFLIICCVPKYGLTNVVVYILICSMVGSLSVMECKGIGLALRETFGGGQNEFSNWLTWFFIFALILCITVQINYLNKALDTFNTSVVTPIYYVFFTTFVICASAILFKEWGNMAATDVVGNICGFFTVISGIFLLNAFREWDISFNNIGNTLQKKEDSRCISKNNMEDNSTSVLIDCHNHRSEETSMLLERHSRQNSLESRTFNNLVNAAESSFNSILPFASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS30</accession>
    <name>A0AAV6VS30_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chorein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_026471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039782">
        <property type="entry name" value="VPS13B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517:SF0">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8198573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="3383" mass="383195" checksum="25F0AF20DD137000" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSC9</accession>
    <name>A0AAV6VSC9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSC9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="136" mass="15378" checksum="9A5303B3F2ED7C06" modified="2024-11-27" version="1">MSKLQRRIKISNKTRNIVAQGVSFLNQVPPLSKPTHQGAKCIPRSAVSARWSESGHPIGPWRAMVALVTDDMCNGVSFWEDGEEVGLWEDEESSLGVGRDEVGENLDLDGRFFFKNLFCNKPFIYLENTHSLDRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSN0</accession>
    <name>A0AAV6VSN0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterol carrier protein 2</fullName>
            <ecNumber evidence="13">2.3.1.155</ecNumber>
            <ecNumber evidence="14">2.3.1.16</ecNumber>
            <ecNumber evidence="3">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Acetyl-CoA C-myristoyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Non-specific lipid-transfer protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">SCP-2/3-oxoacyl-CoA thiolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">SCP-2/thiolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">SCP-chi</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Sterol carrier protein X</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="40" type="ORF">JTE90_023514</name>
    </gene>
    <organism evidence="40 41">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="40 41" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="40">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="26">Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.</text>
    </comment>
    <comment type="function">
        <text evidence="27">Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>3-oxo-(9Z-octadecenoyl)-CoA + CoA = (7Z)-hexadecenoyl-CoA + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:47400"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:87695"/>
            <dbReference type="ChEBI" id="CHEBI:87698"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:47401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>3-oxohexadecanedioyl-CoA + CoA = tetradecanedioyl-CoA + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:40343"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:77081"/>
            <dbReference type="ChEBI" id="CHEBI:77084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:40344"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>7-dehydrocholesterol(in) = 7-dehydrocholesterol(out)</text>
            <dbReference type="Rhea" id="RHEA:62960"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="32">
            <dbReference type="Rhea" id="RHEA:21566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>butanoyl-CoA + acetyl-CoA = 3-oxohexanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31111"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:62418"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="31">
            <dbReference type="Rhea" id="RHEA:31113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:16865"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57373"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58507"/>
            <dbReference type="EC" id="2.3.1.176"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:16867"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>decanoyl-CoA + acetyl-CoA = 3-oxododecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31183"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
            <dbReference type="ChEBI" id="CHEBI:62615"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="30">
            <dbReference type="Rhea" id="RHEA:31185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>dodecanoyl-CoA + acetyl-CoA = 3-oxotetradecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31091"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:62543"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="34">
            <dbReference type="Rhea" id="RHEA:31093"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:35279"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:71407"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="33">
            <dbReference type="Rhea" id="RHEA:35281"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>hexanoyl-CoA + acetyl-CoA = 3-oxooctanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31203"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:62619"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="29">
            <dbReference type="Rhea" id="RHEA:31205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>octanoyl-CoA + acetyl-CoA = 3-oxodecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31087"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:62548"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="36">
            <dbReference type="Rhea" id="RHEA:31089"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:46344"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:86042"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:46346"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:18161"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="EC" id="2.3.1.155"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:18163"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="40">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.155" evidence="13"/>
    <dbReference type="EC" id="2.3.1.16" evidence="14"/>
    <dbReference type="EC" id="2.3.1.176" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000036">
        <property type="protein sequence ID" value="KAG8198751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSN0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050633">
        <property type="term" value="F:acetyl-CoA C-myristoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000016">
        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="41" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="37">
        <location>
            <begin position="39"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="39">
        <location>
            <begin position="298"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="SCP2" evidence="38">
        <location>
            <begin position="488"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00031346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00032093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00033178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00045738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00045994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00049268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00049306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00049542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="39">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="EMBL" id="KAG8198751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="581" mass="63436" checksum="A67A8B13D7397C9D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTV5</accession>
    <name>A0AAV6VTV5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000020">
        <property type="protein sequence ID" value="KAG8200089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTV5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="104" mass="11620" checksum="C4403456E39B4950" modified="2024-11-27" version="1">MFAKSYKLVKSRNRNEGKLQSHGHVISTNYTNISLKKNVQEEDIKPSETTISRFLHQSPRLNGLKHNLPLQSPNTKTLSSTIKTKYKVASTEEAAGSKVGIPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VU54</accession>
    <name>A0AAV6VU54_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_022109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000025">
        <property type="protein sequence ID" value="KAG8199655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VU54"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032034">
        <property type="term" value="F:myosin II head/neck binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051893">
        <property type="term" value="P:regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031865">
        <property type="entry name" value="DUF4757"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15551:SF3">
        <property type="entry name" value="LIM AND CALPONIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15551">
        <property type="entry name" value="LIM DOMAIN ONLY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15949">
        <property type="entry name" value="DUF4757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="1193"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="369"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="621"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="678"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="916"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1049"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="836"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="947"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1081"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8199655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1265" mass="141268" checksum="9B642B023F792AF7" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUL2</accession>
    <name>A0AAV6VUL2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynamin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_025008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000018">
        <property type="protein sequence ID" value="KAG8200230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUL2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF4">
        <property type="entry name" value="DYNAMIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin N-terminal" evidence="8">
        <location>
            <begin position="61"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="265"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8200230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="449" mass="50871" checksum="9AD64D38861B0201" modified="2024-11-27" version="1">MSNRNKKQRSATNPADSVTLSLNERILKECHDFYTDPKNGLIKITSGLDVDLLPPRKKVTILLIGNHSAGKSSFINWYIEEHILKTGVAIETQGFAFVTSGKKRETLTGNATLHLYPHFKPLIEIKRLIDYISTEISTSKQKKFSLVTFIDTPGLVDGEMNYPFDVEKAIQFLGNIADLIFVFFDPIGQALRKRTLNVVESLSAKHGDKIKLFLSKADEAGNETDRQKVLMQIVQELCKRPNLNRAGFDLSTIYLPNPNKPVRCVNQIEDLCKEIEKTINRTVQNTLNTLEADCKKIEDAIITKINTNQKNQSDNLKSSGKGLLFLFSAIVLFSSYVLGILFSSTSRDTIAGFVGQSLAEVILLYLKAFGYVWNSVSDDDHFYISIFVVLVVAVLLIIARWYIRPTPTISKKERKALLERRDYLQTVVINRKRQLYDDYLKQSVADHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVH3</accession>
    <name>A0AAV6VVH3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_000829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVH3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="135"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="705"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8199734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="734" mass="82747" checksum="228BF0CCE581A6BA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWR3</accession>
    <name>A0AAV6VWR3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000007">
        <property type="protein sequence ID" value="KAG8201239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWR3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="11151" checksum="04680DE6E981C7B7" modified="2024-11-27" version="1">MQDHMENMRMDPKHQFATQYVLSWAAAEIRQEDVPGMPLPLHGGTGLSGFRYLGPMSHMGQNHPGLTPCWVTGDLSVEQTCTVSSHFFCLALTTASRRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VY29</accession>
    <name>A0AAV6VY29_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_022248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VY29"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051968">
        <property type="entry name" value="ZnFinger_Homeobox_TR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891">
        <property type="entry name" value="ZINC FINGER HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8200626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28092" checksum="F458BFA21C45C719" modified="2024-11-27" version="1">MYSTPLSLLQLPPTALPEITQKLTQPGNTTARFSQDGKTLEDLKGVVSANDYQQAAEAEVDVGYVCKKCQLVHPAEVLCLNHQRSSCFANNKTSGEIAKAILRLVQVQLECRACRERFPTLLDFKFHCNAERHVKRVHKLQRSEQITPPTSNSMVPPKMPPCSTSSHFAATPVAPSMTPPRMAPPPLLLPQTGNDVTTRNGPDVTAQHLMFSSDFRNDLDSALRLGLEASSLDLPASTKASLCFTGEATLSPEAKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYF3</accession>
    <name>A0AAV6VYF3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_024358</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYF3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000233">
        <property type="entry name" value="Distal-less, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF81">
        <property type="entry name" value="HOMEOTIC PROTEIN DISTAL-LESS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="156"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="158"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8201490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="323" mass="35629" checksum="C211B7490C4A704D" modified="2024-11-27" version="1">MAGTADGLGDQDNSNKSAFMEIQQQGLMQHQGYPIRSTYSGTPSQHEAVFASAHNPRPLGPNPFPMNYPLNSSLHNSYSHPGHPYLSSYPAPGCPPCPSPPRDAASSLVALQSRMMNAPYKYNSRSIKDEPQWDLGYYDVDKSQLEETLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKKMLKASNQQQSAQTPGSTPGLAPPNPASTPHTPPESHDAHSPPSVPLLPPQAAAQGGMPQAAVSPPAMSPPISSWDMASSKAMNVTNTYMPQYSWYHQTDPSMNQQILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYK3</accession>
    <name>A0AAV6VYK3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CB1 cannabinoid receptor-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_027278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CNRIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYK3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031718">
        <property type="term" value="F:type 1 cannabinoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029204">
        <property type="entry name" value="CNRIP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31952">
        <property type="entry name" value="CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31952:SF1">
        <property type="entry name" value="CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15043">
        <property type="entry name" value="CNRIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8201794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="161" mass="18634" checksum="B31223F64A123D46" modified="2024-11-27" version="1">MNKGNTKFSLTINIKREDEKALVYYKQDGQRFESNCTIKMNVETPYKFLISFRPALKLKSGSLKNSGLELKEESFTPEASSYTLFWTSHEVCISKSKGRDRFPLSLNVGDMGTLDVQLQCKFYGADDKSHCLWGNELHHIEYECNYKSDTLSYDIVKEVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZ65</accession>
    <name>A0AAV6VZ65_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cartilage oligomeric matrix protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_015755</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thrombospondin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000012">
        <property type="protein sequence ID" value="KAG8200846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZ65"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1080.10:FF:000004">
        <property type="entry name" value="Cartilage oligomeric matrix protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000025">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000027">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000002">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1080.10:FF:000001">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1080.10:FF:000002">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000232">
        <property type="entry name" value="thrombospondin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003367">
        <property type="entry name" value="Thrombospondin_3-like_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017897">
        <property type="entry name" value="Thrombospondin_3_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008859">
        <property type="entry name" value="Thrombospondin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024665">
        <property type="entry name" value="TSP/COMP_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046970">
        <property type="entry name" value="TSP/COMP_CC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10199">
        <property type="entry name" value="THROMBOSPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10199:SF100">
        <property type="entry name" value="THROMBOSPONDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11598">
        <property type="entry name" value="COMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02412">
        <property type="entry name" value="TSP_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05735">
        <property type="entry name" value="TSP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58006">
        <property type="entry name" value="Assembly domain of cartilage oligomeric matrix protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51234">
        <property type="entry name" value="TSP3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51236">
        <property type="entry name" value="TSP_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="292"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="391"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="10">
        <location>
            <begin position="466"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="10">
        <location>
            <begin position="528"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="10">
        <location>
            <begin position="625"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="TSP C-terminal" evidence="13">
        <location>
            <begin position="700"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="463"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8200846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="970" mass="106946" checksum="B528BEBC25062834" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W546</accession>
    <name>A0AAV6W546_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8201999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W546"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="11276" checksum="D654B15CB1565CED" modified="2024-11-27" version="1">MASFRELPHVPIKLTSHKLPYPPIPRFDETAFQESPLEAGTVSTSSEQGWESQESLNVAKCSNLAPESPRLVKLRQFIYQPSSPEDKVFPISPDSRISHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TE11</accession>
    <name>A0AAV6TE11_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006220">
        <property type="protein sequence ID" value="KAG8156191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TE11"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8156191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="143" mass="15957" checksum="E963D02030847A5B" modified="2024-11-27" version="1">MVLRTTGLSTKHMNQVSEPAVPLVLSRITIATTSLSVGANKAHRTPQSTGAFRGTASLSPDEPIPGTRLLQRKITLPRVLRRRLRVRLRYRTWSRRTYLPVSAFGGILTPIALSSAARQTRQCVAFRHTSRFGTDFSRSLRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TE46</accession>
    <name>A0AAV6TE46_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006246">
        <property type="protein sequence ID" value="KAG8156180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TE46"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="173"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8156180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="387" mass="43447" checksum="7ECBBCBC5028AC2C" modified="2024-11-27" version="1" fragment="single">IDLLSCTFDDKSLCSWKQDQGTLPWKFGGFEEVKSTTPKQPANNQGYYIYVSSYEGIPQTNHELLARIQSPVVSASFNDTSCFSFYYNMFGARVGELTLSIVPLDEKGEPIGKQVIWRRSGTQPDRWFQYKDTMGITEGDYRVEIQGEMGPGFGGYFAVDDISLALGACPNNEVCDFESGLCGWTVEASKEGKFLWRRTVPTKLGPPRDHTSMTGAGYYLQAVNEQGASSNDVTNFVSPKYGKRWGAHCLTFWYWRPGQGNGSLSVLTRNENDKESQLWLEDRDVGMFWHFAQVTVDEIEQVQVLIRAKKGDSEDKEMALDDIHIKNSRCGNPGSCSFNRDYCGYFLDAMSNFSWQLGDGRVVDDMKVESTPQDNSVENGTNLAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TE70</accession>
    <name>A0AAV6TE70_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_008254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006183">
        <property type="protein sequence ID" value="KAG8156210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TE70"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8156210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="140" mass="15913" checksum="32218BA013E93D29" modified="2024-11-27" version="1">MNSVSRPVSEIIKNQDLDEPKKRSREDWRKAKELEEARKAGNAPAAVDEDGKDINPHLPQYISSAPWYFGAKTATLKHQRPQPDKQKEWSKISDDYVRGLKALSRKPMVRQIFPKAAQSYSESKTSVPSLVLTIGYLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJ29</accession>
    <name>A0AAV6TJ29_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003487">
        <property type="protein sequence ID" value="KAG8171844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJ29"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="121" mass="13746" checksum="4242CE6291E5CFDA" modified="2024-11-27" version="1">MGNPLNLFCAGDWRMQIFRQNEEISSKRESSFALLGPLALVHPARRYYRLNILVRIWIGCRFGFRDSLRNGDLNREKPTPAESRSQGRGEMWGLGSKACRRRTLQQVPLTGAVAQSGLSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKM3</accession>
    <name>A0AAV6TKM3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_017340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010003223">
        <property type="protein sequence ID" value="KAG8172036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKM3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000012">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8172036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="160" mass="17835" checksum="1916B967609C1017" modified="2024-11-27" version="1" fragment="single">SVTLHTDVGDIKIELFCEQCPKASENFLALSASGYYNGSLFHRNIKGFIVQTGDPTGTGKGGTSIWGRHFEDELRDELKHNTRGIISMASNGLNTNGSQFFITYAKQPHLDMKYTMFAKVIDGLETLDELEKLPVNPKTFRPLNETRLNSVTIHANPFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLD9</accession>
    <name>A0AAV6TLD9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_017589</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010002652">
        <property type="protein sequence ID" value="KAG8172508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLD9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039525">
        <property type="entry name" value="RNF126-like_zinc-ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14369">
        <property type="entry name" value="Zn_ribbon_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase RNF126-like zinc-ribbon" evidence="8">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8172508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="188" mass="21213" checksum="EAE00995B75BCD8A" modified="2024-11-27" version="1">MAETLRLESKYFCHHCTREFELTDELVCPGCSSDFLEILSKEFYDVENLPSMCDESSESDHETDSDELLISELTMERLLSHMLLNVAENLPPNVDSDVVPPEGPSMFSTDIPSNIVTNVGLRNLSTADERFDWNTDEEIDALAFELLDEINVSGPPPLSKDQMKLLPTVKVEESYIEKELQCTVCMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLL1</accession>
    <name>A0AAV6TLL1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002561">
        <property type="protein sequence ID" value="KAG8172583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLL1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043832071" evidence="1">
        <location>
            <begin position="23"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="114" mass="12729" checksum="A7E9FDE438B79C51" modified="2024-11-27" version="1">MIVRFDCWLVLLAVYCVALVDSIGSDEIEFDNNTFVDNNKFIDNVPFQSDCDCGSHTKSCSYVEGKKKCNVMICMQINKGHACLATVSMPSITNGCEFDDFGRKKCNCLKGYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLR1</accession>
    <name>A0AAV6TLR1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_011582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002443">
        <property type="protein sequence ID" value="KAG8172704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLR1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051843">
        <property type="entry name" value="CPA1_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102:SF1">
        <property type="entry name" value="CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="7">
        <location>
            <begin position="72"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8172704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="186" mass="20619" checksum="E8EF5859BF35B83D" modified="2024-11-27" version="1">MVNLRKYFPPDSIFQHKTSCCSWYRVKENILLLLTQLVSLIFLIGTLYGILGNDVLPGTEIFALLLLAISAYGGGVLAGLIRLPPLVGMLVVGILYRNLSFIPYQKNISIMWASTLREISLVVILLKAGLALDPKKLKEMKLDVFKLSFIPCLFEAATSAVFIHFSRLTCLGSGFHLGYVGQILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLX7</accession>
    <name>A0AAV6TLX7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002456">
        <property type="protein sequence ID" value="KAG8172686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLX7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10468" checksum="6CDCBB0B28903808" modified="2024-11-27" version="1" fragment="single">AHANGSDNPGMEDVAEEEEEGSKRLSPKPKVPHRKYPHRYERHHNKVRGTLKSVSAHVWNHEGKEVLNDIFPMSVDQVFKSLFFSGDQNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMQ6</accession>
    <name>A0AAV6TMQ6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002212">
        <property type="protein sequence ID" value="KAG8172948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMQ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOCS box" evidence="1">
        <location>
            <begin position="109"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="173" mass="20558" checksum="FB238C50933586C5" modified="2024-11-27" version="1">MAVCNRCFHDPNPPVCLKYGREQVFMEPTNPVSTYINGNIIPRNYIIQDVLLFLLELVSSQVLKSNPSMMNCYKLLWRMRTIPYVRLDELTEFAEKYWMNYRCKSCCSNLRRALYFYENMFPDLTTGPVTPRSLKHLSRCTIRKSLNRDSRGKLEIIELQVPIELKQYLRLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMU5</accession>
    <name>A0AAV6TMU5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001910">
        <property type="protein sequence ID" value="KAG8173280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMU5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="8849" checksum="08B4C7805CEA7CF7" modified="2024-11-27" version="1" fragment="single">SVYGHALPFIVISCVCLVASGLSTFLPETLNENLPQTVIDAEKFGKDQKFFSMNKRNPVSKSNHIPVAQNEVEMQENISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TN33</accession>
    <name>A0AAV6TN33_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002189">
        <property type="protein sequence ID" value="KAG8172979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TN33"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="132" mass="15388" checksum="CED0270C3B0015A0" modified="2024-11-27" version="1">MSEESKVLAVSKYSDKKRNFPLTTTTKKPERSCNRCGLRHAANRCPAYKQKCRTCKRIGHFAKVCRNKKTVEETEVRETSPKESLVFVAEMKHDQHNQDWYEELTFRNGCKSNSSWIPEHSVMFSAKNTQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TS09</accession>
    <name>A0AAV6TS09_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_000098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001211">
        <property type="protein sequence ID" value="KAG8174464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TS09"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8174464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="131" mass="14482" checksum="2EC54D069B2C81F6" modified="2024-11-27" version="1">MRNGQRCSSAKAYLVPADDRANLDIVTHAFVEKVLIRDKKSVEVKFKHGGSTHIVSARREVILSAGTINTSQLLMLSRIGPKKHLEDLQIPVKTDLRVGENLQDHQAVPVPFQIDPSIPSILQKGSEPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSM0</accession>
    <name>A0AAV6TSM0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001118">
        <property type="protein sequence ID" value="KAG8174907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSM0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="95" mass="10820" checksum="4E8E25AEC2127754" modified="2024-11-27" version="1">MDEENIVQNVDEETTQPHEENGPQNTDEETTQPHEENVPQNTETTQPHMDSDNESCHSFSSYGLSIYDDFPCLRGKPGCECKCYRHPMCGCCFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUP8</accession>
    <name>A0AAV6TUP8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001049">
        <property type="protein sequence ID" value="KAG8175175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUP8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="635" mass="73803" checksum="DDCAD23C890B34AB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TX73</accession>
    <name>A0AAV6TX73_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000939">
        <property type="protein sequence ID" value="KAG8175936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TX73"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="198" mass="22057" checksum="37A190C37479E75D" modified="2024-11-27" version="1">MTSKSKLFTPGPYHSVDYVVKMYFKSVYNQAGDLVAEQPLVWHALSTGECMKSLVVVTQLVKSFLLAENRRFFQVPGDAFVVPPSELMSFLVQYFLPFVLGSTTLLGTNCWSTFKYLRGNLGVRNVVLIGLVGCTPHLTSKLQLLRLYCKVRKDRELNEFRPPLPKQDESSGIADNAVVENDGEANDVCASQQSNAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYP1</accession>
    <name>A0AAV6TYP1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_023677</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000857">
        <property type="protein sequence ID" value="KAG8176673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYP1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8176673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8396" checksum="3F8F849B5246803E" modified="2024-11-27" version="1">MKLYFIFNRFEVTTFVHERKFESVSLFSYIGGFMGLWLGVSLIALFDLAETLVNLLVIYPLSQSSRRKTRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYR5</accession>
    <name>A0AAV6TYR5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_028618</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000862">
        <property type="protein sequence ID" value="KAG8176636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYR5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8176636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="260" mass="29845" checksum="8612F4BD119D232F" modified="2024-11-27" version="1">MHKGYTILAHNLKGFYGQFNLKWLLENRYEPKVIRQGSKLMSVEVTPLQIRFIDSFNFLPMGLSKLPKTFGKEEIAKGYFPHLFNRPENQAYVGALPDAHFFSPDTMSPAEMTKFYQWYEGRQSMPFNFQEEMQLYSRYVTIAVACMACYRSQHILDGTIAMMPQHGYVNNTNSSADSIRWIDYVAHENGLFISQAKNGNGEIKIGGFSVDGFCETTRTVYQYPHGCFYHGCSFCFNPDVENPVSGLKMNVLFKKTEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1B8</accession>
    <name>A0AAV6U1B8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000708">
        <property type="protein sequence ID" value="KAG8178257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1B8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7680" checksum="4B3340A8FE68826B" modified="2024-11-27" version="1">MTRSGPQLSSSQPPFPCIRSPCSKTDGINGLVSTFTHRDFRLKLRRPFLEANEGSCPFVVVATRAPNTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U229</accession>
    <name>A0AAV6U229_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_023246</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000685">
        <property type="protein sequence ID" value="KAG8178552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U229"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF13">
        <property type="entry name" value="MITOCHONDRIAL CALCIUM UPTAKE 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="374"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8178552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="434" mass="50435" checksum="E209CBD2F13A2066" modified="2024-11-27" version="1">MFSAVKNNQERIYYATATVGAGITLYVFSDKLQKFGTKRDIGLVRANQYSKGNKEDDNMQMSQLTQREKRFIKFASVEYDGQLYMTPQDFLDSVTETDPRPRLKRKIMNKKEIHSLYDSTPSRRKGNTSLFRSLHDKGIISYTEYLFLLSVLTKPQSGFRIAFNMFDTDGNQRVDKKEFLVVLHLLVKSFFKRTAENSGPYSNISPQVLEKIFSTVARKGNMLRRKDRSGSDDDSDFDSVDTTLLIHLFGKKGNEDLSYDDFYRFMDNLQTEVLELEFTEFSRGMPTISEVDFARILLRYTLVHSSDYEAYIERVHERIPDERGISFSQFKAFCQFLNNLDDFSIAMRMFTFANRPISQEEFHRAVAICTGHSLDGNLVNAVFQIFDEDGDGQLSYKEFIAIMRDRLHRGFKSHLVKTEGWEAFKSCIKTEMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2V5</accession>
    <name>A0AAV6U2V5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_027835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000742">
        <property type="protein sequence ID" value="KAG8177866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2V5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF54">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043787072" description="ZP domain-containing protein" evidence="9">
        <location>
            <begin position="30"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="10">
        <location>
            <begin position="46"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8177866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="414" mass="45948" checksum="30A530C458DFE89A" modified="2024-11-27" version="1">MSVPGTDTMKTRWLYFLIVMSGMHQMTSAQLLLKSASSLVSDVHISCNSNSILVSISTATAFNGMIYPKGLSKNSTCMQEYHDVQAGLINYTLPLRTCNTMSADFNEGIEYFNTVVIQPHRKLVTSQGRGYHVRCRYQTRDQTITSNFNVSMLGTTPLTATAPLPACTMKIFVGDGQDQIVAENVKIGDLLSLVIAIDFQEAYGLKVTNCLVRDGLNWGEQPLINNEGCPVDEDILGPFEYARNKTVARVTFQAHKFPYTSSVYYQCNVKMCLKQAGGCDDVPPLCDEEGYNIRRRRRRSSGDQVEDIGSLQALRLEEVHARDRSVEVFSGLYVSEVDEQRSNELPLEGDHRNPLSTDLCMSTRKLAAGVAVSGILLVLAVMLLVVCVLHKRRRRKTPAVYSGGPYANSAFVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U390</accession>
    <name>A0AAV6U390_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_014123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000659">
        <property type="protein sequence ID" value="KAG8178917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U390"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021066">
        <property type="entry name" value="FPI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053741">
        <property type="entry name" value="Ser_Fungal_Prot_Inhib_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12190">
        <property type="entry name" value="amfpi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043888120" evidence="2">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8178917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="133" mass="14680" checksum="93CD55E848749371" modified="2024-11-27" version="1">MQLEVFLLLTAVLTASSLFACPEDYCDNIQCEDVSCGPNEEFNLHGTFCGCCPACIILVEKGDKCPIRIFNGGPPPTVLKYLRTCRNESYNNDEADNYRVFLCDRYVNGHVGGRSSNGLQENSVRDAPMSTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3S0</accession>
    <name>A0AAV6U3S0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_021008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000683">
        <property type="protein sequence ID" value="KAG8178588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3S0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06148">
        <property type="entry name" value="Egl_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056589">
        <property type="entry name" value="WH_Egal-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46814">
        <property type="entry name" value="EGALITARIAN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46814:SF1">
        <property type="entry name" value="EGALITARIAN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23713">
        <property type="entry name" value="WHD_Egal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="349"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8178588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="776" mass="87492" checksum="A24B4FD69249D5A6" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U444</accession>
    <name>A0AAV6U444_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SYO1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_016049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000652">
        <property type="protein sequence ID" value="KAG8179040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U444"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="2">
        <location>
            <begin position="393"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8179040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="652" mass="72951" checksum="71FBAD4BF4D2E124" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U631</accession>
    <name>A0AAV6U631_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_010253</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000633">
        <property type="protein sequence ID" value="KAG8179358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000037">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000119">
        <property type="entry name" value="vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052080">
        <property type="entry name" value="vWF_C/EGF_Fibrillin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333:SF4">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333">
        <property type="entry name" value="VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043596774" evidence="10">
        <location>
            <begin position="21"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="683"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="776"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="817"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="914"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="980"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="12">
        <location>
            <begin position="1126"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8179358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1298" mass="145591" checksum="03FCD588D1D7779A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7D7</accession>
    <name>A0AAV6U7D7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_001837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000616">
        <property type="protein sequence ID" value="KAG8179596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7D7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000003">
        <property type="entry name" value="Pyruvate dehydrogenase phosphatase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000004">
        <property type="entry name" value="Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF15">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="5">
        <location>
            <begin position="419"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="477"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="782"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8179596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="896" mass="101257" checksum="603388C648925A62" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U823</accession>
    <name>A0AAV6U823_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_016363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000567">
        <property type="protein sequence ID" value="KAG8180329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U823"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8180329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="227" mass="25841" checksum="E47812FE8DC3B288" modified="2024-11-27" version="1">MSAVAQLTISRNLIFTDDPDMYKNVSELISSKDYPVENHIVETQDGYVLQIQRIPYGRNGTREANKQVVFIMHGLLSSSNDWVINFPKQTLSFILADAGYDLWMGNGRGNVYSKKHKNYTTDMAEFWNFSFDEFAKYDIPAMIDFILKKTGQEELFFIGHSQGNTAGFALLSERQEYNKKIKLLIALGPVTTLIHTSGPLKYIAPLTHLGEVLSIIHYTVNCIRNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8E2</accession>
    <name>A0AAV6U8E2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_028866</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000568">
        <property type="protein sequence ID" value="KAG8180317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8E2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="278"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8180317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="500" mass="57721" checksum="F8C4CB189A1F18B6" modified="2024-11-27" version="1">MSALLLGAPLSALRWGVQWELFRWIVPVFVFLVVCKIATADDRMEVVQPLLTLLFCWISYTMQNDIRMTDDDCERTEELASKRSKKIKASLSNTATPNPKRKNNRKDRKKRVRIEREKPKEEEEEPRSRAHSQRLMEELPEFTELNMPKRNVYHGVSSFVLTHRELVRNDYPLDTKERPGRVQTRSSLPKHQTRRRCARCKHSFQIIDNKYHCETECIHHLPVKPSPVTGRFTCCNGNQWSEGCFVSPFHVTAEHCLEDVVFSRIRNKRHVKAEDAYGVYGLDCEMSYTTAGLEVTKICLVGVDGITIYDTHVKPDNEILDYNTDYSGVTAEDMTKATTTLADVQAYLLKTLHKDSILVGHALHNDLKALRIIHDRVVDTSVLYPHSDNPRLKFSLKTLAKDVLHRNIQVDQHDCIEDARTCLALVLRKVTLDNCCIPVVPSQDENRNGYLLNHSGPIAHQAEMLHCMHQGEMMFVPYNCRVETAWGYPQTGYWNIFYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UB88</accession>
    <name>A0AAV6UB88_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000539">
        <property type="protein sequence ID" value="KAG8180973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UB88"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="14361" checksum="901E8CE4C4CCE260" modified="2024-11-27" version="1">MDAEKRAKNNAKQKRYYEKKLNDPNFKEKERLRQKKIRNAKSKIMTKKEKRKQMEAARERQRKCRASKKTKDVMQCSSLNSTVAQEASPYRVPQTLGKAVKKIMECITVLTSKAEGRYEQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBC4</accession>
    <name>A0AAV6UBC4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000530">
        <property type="protein sequence ID" value="KAG8181158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBC4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="147"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="368" mass="42069" checksum="5A436C16EA0BBAC0" modified="2024-11-27" version="1">MPKYYLSIPPNSLELPIEKHCMDLLRRKHKSSGNPSIVLVIKSAYPSTCNQPPVYANLGAISSCTKKQNGREEVVSNESDVGVENVGEGKENGKVKKRTEKSTAHTKTYITPGKEQPNHRNFQMTRSDVNLTKKATNKLTNVSRIRPDVTIVIKDREFRLHKKVLCEESSYFSKMMDPNSSRQYTLKLDGKLNTSPDIFHYIMTFLYCGEMEPNKVSTLETICSASRVLGIQRAVDNSLEEISCHRNSLTSALRSYCFRCATNGGKNSHFMYSLTSPCNLASNTHSKTQTFRNESESYWNNTLFTSVRGYYGQRIAMPYYPNHLKALPEKFKKKPTFEYLEYVNMTMIGLYQLNIRTFINFISNKQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBY2</accession>
    <name>A0AAV6UBY2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000492">
        <property type="protein sequence ID" value="KAG8181860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBY2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="115" mass="13020" checksum="FB11F3F6C36B9447" modified="2024-11-27" version="1">MADALEDEELEILKRNPKLRIIQVSIPNSSKAPKYFDIEIKGIVKRISIDRLKPCFTLHENSEQSKTDASSTAAMDPPPTPCPNKSDKLLPEGGSYMTRRGRKVKFSKHLEHYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDV8</accession>
    <name>A0AAV6UDV8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">dihydropyrimidinase</fullName>
            <ecNumber evidence="8">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_000044</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="8"/>
    <dbReference type="EMBL" id="JAFNEN010000487">
        <property type="protein sequence ID" value="KAG8181933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDV8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006208">
        <property type="term" value="P:pyrimidine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000001">
        <property type="entry name" value="Dihydropyrimidinase like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="11">
        <location>
            <begin position="78"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="504"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="9">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8181933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="599" mass="65595" checksum="36AC6536F0C4523C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEP2</accession>
    <name>A0AAV6UEP2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_013909</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000469">
        <property type="protein sequence ID" value="KAG8182303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEP2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8182303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="194" mass="22609" checksum="1945649E0D2CD2A0" modified="2024-11-27" version="1">MEVLKIKNLICYSFKGEAMPFTEDFNLPSVEDLTAQEIDISAHYLKAGAVHFGKYCDEPCKEFMLCRRELNDPRKCLNEGKEVTSCGLEFFQKVKKSCRSEFEQYADCLEWNSSEMKVEYCRKTQAALDGCMLEKLKIERPYLGYFTEIRVHKSDRPKPESVLPRKKYVDDRPSLPDDYPRDPAKFGSAFFVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEX4</accession>
    <name>A0AAV6UEX4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_018486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000456">
        <property type="protein sequence ID" value="KAG8182650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEX4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8182650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="273" mass="30040" checksum="DA1A710431C9CB30" modified="2024-11-27" version="1" fragment="single">MFYAHFVLAKKGPLARIWLAAHWDKKLTKAHVFETNIESSVEGILQPKVKMALRTSGHLLLGIVRIYSRKAKYLLADCNEAFIKIKIAFRPGMVDLPEGNREAAVAAITLPEVFHDFDTALPDITIDMDAQVSLNQSRAEDITLKEDYGNLSLMADDGFDDMGFEDVENHREDGFDETGLFLSTEVTEETPGKPKVSLDQPLKDDGFGAPVGEGILDGNTGVLFEPGGLFDDAPLGVEPDNQATEPAPVDAHQIQEKPIEPHAAEEDSDDDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF71</accession>
    <name>A0AAV6UF71_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_000047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000487">
        <property type="protein sequence ID" value="KAG8181936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF71"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="185" mass="20486" checksum="4E99D1DC0B41CFD3" modified="2024-11-27" version="1">MSTLDLVVKAIETIGAPRRGASYLAIQKWISSSRENVATNRLKTDLKKAIDKGFKSGILERPTISKNVTGLRGYFILNKDVIAQKKQDEVETAEKLEEKAQVTEVVKTKAAAVEIAKAVTVKKTKDAATQTKEAPDSAPAQEPDPDEVRRERFEMEWNRKLFLLMCAMESSKSNDSGQGSSLNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGP6</accession>
    <name>A0AAV6UGP6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_026186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000451">
        <property type="protein sequence ID" value="KAG8182735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGP6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031847">
        <property type="entry name" value="PDLI1-4/Zasp-like_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15936">
        <property type="entry name" value="DUF4749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="483"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8182735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="669" mass="75934" checksum="93E2C7125E5AAE9F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJH0</accession>
    <name>A0AAV6UJH0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_012641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000370">
        <property type="protein sequence ID" value="KAG8184552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJH0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="51"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8184552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="207" mass="23772" checksum="70C383E69A9D0C2E" modified="2024-11-27" version="1">MQITSSPISMWAPVGDFQTQESSAPLGCSLSNGTQAIPEDRELCPGGTAMPHVFVADEAFPLQRHIMRPFPRSQLDSRTRIYNYRLSRARRIVKNAFGILSARWRVYKRPFECKLQTVDKIVLATCALHNFLGQTGGHGNISSEKITTSLEENENQLLDLPRIGNNPYREAFIVRDMFCNYFENMTWQNQVNSVKKNCKYLYLLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UK27</accession>
    <name>A0AAV6UK27_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">39S ribosomal protein L20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_005633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000412">
        <property type="protein sequence ID" value="KAG8183646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UK27"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="entry name" value="Ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_bL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_bL20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="Ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8183646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16937" checksum="AFB37BBC752A0097" modified="2024-11-27" version="1">MVFLSMVNFIKRSGFDPSIKKQRILKLTAKYYGRKRNCYSVAIKFLQKALRYTTASRKIKPQYVAELRKTRIDAAAAEHGTSGLSLAHNLIKCRVSLDNVILQDLAIWEPQTFKCLTDLAKYKEKLEANPQKAERLKFPEGVITKGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UM49</accession>
    <name>A0AAV6UM49_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-2-macroglobulin receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000378">
        <property type="protein sequence ID" value="KAG8184306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UM49"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050750">
        <property type="term" value="F:low-density lipoprotein particle receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048259">
        <property type="term" value="P:regulation of receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.10">
        <property type="entry name" value="RAP domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038003">
        <property type="entry name" value="A2-macroglobuin_RAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010483">
        <property type="entry name" value="Alpha_2_MRAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009066">
        <property type="entry name" value="MG_RAP_rcpt_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036744">
        <property type="entry name" value="RAP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16560">
        <property type="entry name" value="ALPHA-2-MACROGLOBULIN RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16560:SF2">
        <property type="entry name" value="ALPHA-2-MACROGLOBULIN RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06401">
        <property type="entry name" value="Alpha-2-MRAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06400">
        <property type="entry name" value="Alpha-2-MRAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47045">
        <property type="entry name" value="RAP domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin receptor-associated protein" evidence="1">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin RAP C-terminal" evidence="2">
        <location>
            <begin position="115"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8184306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="38064" checksum="BBBBED649B3497A2" modified="2024-11-27" version="1">MNTQDSNKLVTLEKPFRMQKLNLIWEKAVKKLPVEKLKLLHTDLKFQDKDELELKRKKSEGQDKNGLKEGLVLASFKAILEKYQLQDDFKALQDAAMVSKPSKPEMPNDAYVKNVFRDKKLNKLWLKAEQQGFSEEQLQTLKEEFEHHQNKIDQYDQMINQVHAKTLEVFAGSQDENLDNTVEHVIQAEVGDKFWKSENPYQILKEKHSQLKSGYEYLNTKIMLDIRNTEFDNPQVNSLWEMAKNASFSPKELESLKNELHHFEHRIRKLKTLTALEMETDDSNMVDEVAFKRQKKLKEYNYKVEKIQKELTSRILQKHIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNJ1</accession>
    <name>A0AAV6UNJ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_004396</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000322">
        <property type="protein sequence ID" value="KAG8185854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNJ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8185854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="131" mass="14768" checksum="C82320500D9B4A93" modified="2024-11-27" version="1">MHLFLRCQDLHPIEVGDEKVSYLKRFVEESEGISTEEQTLYFGGVPLEDEQNISECLTEGCTVDVCVKLLGGKVHGSLARAGKVKGQTPKVEKQEKKKKKTGRAKRRMQFNRRFVNVVVTFGRKKGPNSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNV3</accession>
    <name>A0AAV6UNV3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000337">
        <property type="protein sequence ID" value="KAG8185383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNV3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="82"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8185383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="251" mass="28891" checksum="CB2FA65899D4A497" modified="2024-11-27" version="1">MEVVVYGALTTIWWMSSMSVLLPLLLLLKFNKFFRDRWFSFFFERVLGPIYAPKMVPLRKKAFGFLEKHLKDRDNSKQLDILEIGIGGGSNLQFYPENSSLTALDMNESFEKYFAENRKKHPQIKYARSVVAVAENMTEVEDSSMDLVICTYVLCSVMEIGQALSEVKRVLKPGGKFLFLEHVAYPRTQWGNTIQRFVAPLWKIYFDGCMPHQNIGEKIREAGFSNVELENFCPSGFMLFVRPQIVGIATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPB0</accession>
    <name>A0AAV6UPB0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000332">
        <property type="protein sequence ID" value="KAG8185548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPB0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8876" checksum="CF109B65E7B5A960" modified="2024-11-27" version="1">MDIFEKGTVISAPSPSPLQEKGGKRHKIGISLPDRTFLSSRLIFRIFLALSIVCRIELKKLKKYKEKSTVAERLRNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPU2</accession>
    <name>A0AAV6UPU2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000309">
        <property type="protein sequence ID" value="KAG8186220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPU2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="14338" checksum="9B415F14E56585B1" modified="2024-11-27" version="1">MSITHQTNKNAQNKCRQHKNLVYYKNTYYGPYISYPLLNAMLPTKKRKQKSSKKGVELKRLYDGKLPIKTAKLKDLLHLPQYLEKKKKRGVFTKAWDLADLKDDDEDSDFIDDPPMDCEEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQD9</accession>
    <name>A0AAV6UQD9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cell growth-regulating nucleolar protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_014769</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000294">
        <property type="protein sequence ID" value="KAG8186697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQD9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2100:FF:000002">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058719">
        <property type="entry name" value="WHD_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25879">
        <property type="entry name" value="WHD_LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="10">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Cell growth-regulating nucleolar protein-like winged helix" evidence="11">
        <location>
            <begin position="202"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="147"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="147"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8186697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29909" checksum="6B0F37BCE8D56578" modified="2024-11-27" version="1">MVFFTCDACGQSVKKNQVENHCFQCRGCRSLSCMDCNVVFWGDDYKNHVKCVTEDERYGGKDYQPKASSNKGEIKQEKWIEHIQSTISSKKIPGPLSGLLNQIITYSNIPRKQSKFENFLKNSLKIRNPNLISQAWEIFAQSTKNESESSKVTVNGTKAVNGTNGVNHNTSTKRSADSPSVQTAKKPCLDDSSNSKEVVSKNNFNWCEAAEKVLLDFPSGLSEKKLRKEVIAQYKAAVATCSLSNSELKKIFRNNVLQSPSFCLNVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQU5</accession>
    <name>A0AAV6UQU5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000287">
        <property type="protein sequence ID" value="KAG8186840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQU5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="11092" checksum="D85170AFEB9CF4B0" modified="2024-11-27" version="1">MGASTSLMTLAAFSASMMNLQRKLHVNFNEQLEHIDVKRIQPDAVEFNEQLKKRTHTSVPSHPRMDSSLRSRSFMCRRFINVDSKLGRCSTYASGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UR62</accession>
    <name>A0AAV6UR62_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000289">
        <property type="protein sequence ID" value="KAG8186801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UR62"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040154">
        <property type="entry name" value="Biotinidase/VNN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609">
        <property type="entry name" value="BIOTINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609:SF27">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043451046" evidence="1">
        <location>
            <begin position="23"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="148" mass="16571" checksum="E6F6CCCBDDE85A61" modified="2024-11-27" version="1">MSLNIRSLSVLVIFCISSSMPADKDSYRAAVLELVQFADLSYSPSEVAQRNLKIYDTAAIRAAIDMNRSIILELSEDIPNPKLKTYNPCKEKDLDDHPILTELSCIARETGIFVVANMIDRKNCEFAQFCEADTPELCTKTAMNVPMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USU4</accession>
    <name>A0AAV6USU4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Voltage-dependent L-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">JTE90_022871</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Membrane</location>
            <topology evidence="1 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000285">
        <property type="protein sequence ID" value="KAG8186903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009582">
        <property type="term" value="P:detection of abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009581">
        <property type="term" value="P:detection of external stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042045">
        <property type="term" value="P:epithelial fluid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000007">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000009">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000107">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000006">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000010">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000064">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005446">
        <property type="entry name" value="VDCC_L_a1su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
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        <property type="entry name" value="Voltage-gated potassium channels"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17 18" id="KW-0106">Calcium</keyword>
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    <keyword evidence="8" id="KW-0677">Repeat</keyword>
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    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
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    <keyword evidence="10 18" id="KW-0851">Voltage-gated channel</keyword>
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        <location>
            <begin position="473"/>
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        </location>
    </feature>
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        <location>
            <begin position="511"/>
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        </location>
    </feature>
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        <location>
            <begin position="599"/>
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        </location>
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        <location>
            <begin position="679"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="854"/>
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        </location>
    </feature>
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        <location>
            <begin position="885"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="971"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1095"/>
            <end position="1122"/>
        </location>
    </feature>
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        <location>
            <begin position="1174"/>
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        </location>
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            <begin position="1206"/>
            <end position="1226"/>
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        </location>
    </feature>
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        <location>
            <begin position="1390"/>
            <end position="1414"/>
        </location>
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        <location>
            <begin position="1548"/>
            <end position="1582"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
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        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="713"/>
            <end position="740"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="1722"/>
            <end position="1750"/>
        </location>
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            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
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        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
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        <location>
            <begin position="716"/>
            <end position="729"/>
        </location>
    </feature>
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        <location>
            <begin position="778"/>
            <end position="799"/>
        </location>
    </feature>
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            <begin position="1722"/>
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        </location>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="326"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
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        <location>
            <position position="655"/>
        </location>
        <ligand>
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            <position position="1068"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        </source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01062"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAG8186903.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1902" mass="214713" checksum="0265270B9D1B8878" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="1" type="ORF">JTE90_019949</name>
    </gene>
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        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
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            <taxon>Erigoninae</taxon>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="69583" checksum="98EF17019CADEB58" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTS3</accession>
    <name>A0AAV6UTS3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000294">
        <property type="protein sequence ID" value="KAG8186646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8129" checksum="434CD25C128E2586" modified="2024-11-27" version="1">MTGAIQMFGPEMTGVRRKPTLPSKTIERGSLPCFKTLLEGLVITPMATFENRKGFGGPIGLLRRTLVRMGTLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUX0</accession>
    <name>A0AAV6UUX0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ADP-ribosylation factor-like protein 5B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_029599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000266">
        <property type="protein sequence ID" value="KAG8187599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUX0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903292">
        <property type="term" value="P:protein localization to Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04153">
        <property type="entry name" value="Arl5_Arl8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000294">
        <property type="entry name" value="ADP-ribosylation factor-like protein 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8187599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20569" checksum="B4CF6E1A953697D3" modified="2024-11-27" version="1">MGILLAKIWSLFTNEEHKVVIVGLDNAGKTTILYQFLMDEVVHTSPTIGSNVEEVVWKNIHFIMWDLGGQDSLRAAWNTYYSNTEFLIVVVDSTDRERLSITKEELWRMIAHEDLTKSAVLIYANKQDIKGCMSPAEISEQLNLTSLKKHRWHIQACCALSGEGLFQGLEWISSNLKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVL2</accession>
    <name>A0AAV6UVL2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRK SH3-binding GNRP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_022551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000240">
        <property type="protein sequence ID" value="KAG8188350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVL2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000009">
        <property type="entry name" value="rap guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF224">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="748"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="897"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="547"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="644"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="686"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00083313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8188350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1132" mass="127900" checksum="1EE9045F62957245" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWF2</accession>
    <name>A0AAV6UWF2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_029046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000248">
        <property type="protein sequence ID" value="KAG8188118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWF2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF212">
        <property type="entry name" value="MIP26555P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="147"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8188118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="357" mass="40876" checksum="6F20CC2AB974B805" modified="2024-11-27" version="1">MSLLGKDSSKSNLTMQSNDNKHSKGKNKSSTNKTSNAEHSDNKCKGTPLPELPALEGYLSYMMKEITPELAAHAKLNLNETEESRREGLRKMREILKADPDLKFTDTDDFLLIFLRSRKFDPKRSSDFFKTGLSYIESYRHLLDRKDPEVIRSIIGSKMVGFMPYRDAKGRAIIYARADKWDWTTIPAGDAIFGGVVAVQSAAHNPVNQVSGFVVVLDLKDLKIQQVLAMTRWLIFGTITLQRACPCFMKAFHVINVPPIYKIGWKLVKPLLSEKIRKRFIFHKSDDLSTLYEYIPQEILPKELGGPYPFTNDYWAQDIDLIENLYYSYLDNNYFISKRKGKTTGRKNSISNIPKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWR3</accession>
    <name>A0AAV6UWR3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_015611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000261">
        <property type="protein sequence ID" value="KAG8187741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWR3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="522"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8187741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1049" mass="119610" checksum="EF9834203A488999" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWT8</accession>
    <name>A0AAV6UWT8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mut7-C RNAse domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000244">
        <property type="protein sequence ID" value="KAG8188268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWT8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mut7-C RNAse" evidence="1">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="124" mass="14396" checksum="C1D9286BC59025D8" modified="2024-11-27" version="1">MVCNSNQYIKINKDQLYSLWLERVGFHLPSNAKSKKNHQHYFCDFTSTNGRKYSDVKVLLSSFSEQAFENVSEFFICEGCGKVYWEGSHLSRLKSFVSNYVDVKSTQEGNVYEVLSKNESQKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UX72</accession>
    <name>A0AAV6UX72_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyhomeotic-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_014969</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000227">
        <property type="protein sequence ID" value="KAG8188916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UX72"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09577">
        <property type="entry name" value="SAM_Ph1_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012313">
        <property type="entry name" value="Znf_FCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038603">
        <property type="entry name" value="Znf_FCS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21319">
        <property type="entry name" value="zf-FCS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51024">
        <property type="entry name" value="ZF_FCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FCS-type" evidence="10">
        <location>
            <begin position="746"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="859"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="450"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="785"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8188916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="933" mass="101919" checksum="A386D4FEDF75DDC6" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXI4</accession>
    <name>A0AAV6UXI4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-dependent kinase-like 2</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_009929</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000251">
        <property type="protein sequence ID" value="KAG8188056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXI4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07847">
        <property type="entry name" value="STKc_CDKL1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000049">
        <property type="entry name" value="cyclin-dependent kinase-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000261">
        <property type="entry name" value="cyclin-dependent kinase-like 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF222">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="34"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8188056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="379" mass="44098" checksum="B9A70C0BD6769C9E" modified="2024-11-27" version="1">MFLSYSDYDQKRSSQGSELAFNRESCIRRPMERYEKISKIGEGSYGVVFKCRSRDNGQLVAIKKYVETEDDPLIKKIALREVRMLKQLKHPNLVNLIEVFRRKRKLHLVFEYCDHTVLDILEKHPKGVPEQLTKRILWQTIQAINFCHQHNCIHRDVKPENILLTKEGIVKLCDFGFARNLSPGENYTDYVATRWYRAPELLVGDTHYGPEVDVWAIGCVAAELIRGEALWPGKSDVDQLYLIRRTLGELNPRHMQIFKKNDFFNGISIPDVDVRESLESRLPVNIAEAELDFLKKCLDKDPEKRFSCEQLFHHPYFDGFSKSEIDNDLLSARFRRDKLKSGHYQMLLPQLSNNSLGSSSDMRSSNARSMKKYDPLPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXT6</accession>
    <name>A0AAV6UXT6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7802 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_016625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000226">
        <property type="protein sequence ID" value="KAG8188959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXT6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056704">
        <property type="entry name" value="DUF7802"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35982">
        <property type="entry name" value="AGAP005361-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35982:SF1">
        <property type="entry name" value="SPIROCYCLASE, AVEC FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25085">
        <property type="entry name" value="DUF7802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7802" evidence="2">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8188959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="240" mass="27863" checksum="C57B4DBED215F071" modified="2024-11-27" version="1">MEGLAQDEVTRNLTAKVKHSISEDWLISFKDPITLWEEHWFALTLEVANAIILYNIFRYAKRKGNESCYLVLASMFTAICFELLPLIPQAGYQLWWYHQGMVNIVNRRVPSYVIIAIVHYVVYNLTRDSNLPLLIRSLVSGLCGIAMYCPLLWLAPRLLLTIIHFDDVVFRDSIFGVPCVQIMFMFFMFLHTSQVFIPNYRALEDRDRSTYNLVWCSVQSGLVAAIYAVVEQYVLYILIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0G6</accession>
    <name>A0AAV6V0G6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000211">
        <property type="protein sequence ID" value="KAG8189578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0G6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8298" checksum="8D3C4B3E741A5A4C" modified="2024-11-27" version="1">MKTLRRLLNSSVFMGYLMGPHTLKELDLLPCYQFWYFSTAGDSYLRSVVSEPNAPIVKQQSLDFMLSKSFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V118</accession>
    <name>A0AAV6V118_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000214">
        <property type="protein sequence ID" value="KAG8189485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V118"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="82" mass="9320" checksum="896CBDA8C4099AA9" modified="2024-11-27" version="1">MEGSLITRPGIREFFSAITPKRETSRDVTDDVENDIRVSKLDWTPQSQARRDSDERISWMKNASEDGCPNKKRVDVRSHGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V266</accession>
    <name>A0AAV6V266_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S26, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_026695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000193">
        <property type="protein sequence ID" value="KAG8190127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V266"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026140">
        <property type="entry name" value="Ribosomal_mS26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14943">
        <property type="entry name" value="MRP-S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8190127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="229" mass="27361" checksum="1209066D1520E5FB" modified="2024-11-27" version="1">MAFISRVSFSTFLKLREASVKIPSTYVQLRWLKKEPKRKPKWLPTAPSKLYRIIEHPYVSPEEKQLQLDLHEEYYTQIESMRKMFQEELAQKNKEEGKTLKGQQEEEEKFLLLLEENKKENERIKVIREATIEKLFQEQQLEFMQLEESRKIQEQETKARIEKIVREQKEITKSYITHSNLDEAVERALDSPRNFNFTIDVNGKVNFEGNPPPDFEEDIKQRIAQSAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2E5</accession>
    <name>A0AAV6V2E5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_001292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000177">
        <property type="protein sequence ID" value="KAG8190684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2E5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8190684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="10690" checksum="29EFEDC9EB5D5EB8" modified="2024-11-27" version="1">MTILLPNNRYSGVDILANNLTPQRLQNLFLNDMYPREVKVSLPKFKMEDSFELRLFSKNGAKNLFDRRELIYLVHRTREFPVDAVIHRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4Y6</accession>
    <name>A0AAV6V4Y6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_006106</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CDC42SE/SPEC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4Y6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000004">
        <property type="entry name" value="CDC42 small effector protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039056">
        <property type="entry name" value="SPEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502:SF6">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="11">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8191361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="138" mass="15600" checksum="16315003785B5429" modified="2024-11-27" version="1">MGSKKKSPRAQIDCFELKLPKYFTSYFLFSEVCVGVKLRPEGGHRGRGAVLQQRMSEIWIQCFSCCITQEPPPPTTKRRHRIDRSMIGSPTNFRHTAHVGSGDMNVHLNSLQHQMASKGGYEYAIPVNVHISVVDLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V542</accession>
    <name>A0AAV6V542_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_024883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000175">
        <property type="protein sequence ID" value="KAG8190756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V542"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8190756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="294" mass="34610" checksum="8B924B7B4D9B0383" modified="2024-11-27" version="1">MFEIGNLLDKLLFGTKIHYNNVVYYPVLYSLITLNFFILIGGLVAYIRCRHRKEKPTRKKRVKRKTTVNRTKRKQSPKYSSSSSTTSESDSSRSFKIKVVPKTRPDYASQSVQTKTSARYKNGGNNSVKSMRTKRNYNDTITQRHDYKTQANCSPRVFVPQFTVSTQTETIRPSVIKKTSSTQTNSMNLEQNQLTFMETSLNIPNFPCNKHYSNYPEPAQKMYSHRHQNFQRDHPAIRDKYSPDKYECDYYRTNDHNMVTHPEENHNFYEHPERKTFFGVHLKPVHSPQINLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5L1</accession>
    <name>A0AAV6V5L1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000157">
        <property type="protein sequence ID" value="KAG8191586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5L1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="153" mass="17685" checksum="5DB06AD287CCD9CE" modified="2024-11-27" version="1">MKKFCCARAKRKTATSKKVAEEVITNLQYYIYSYLTVIFATMSKFFNKLFCNVRKFNFKYCIGGAKVTKCAFLKFNKWVSQACLPIYQASQPWEVVIPCPFKSITQVVKNGMSLDSLEIKLELFVVEHIHRDGCLPGWQAVSRGLTLQRLYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6E1</accession>
    <name>A0AAV6V6E1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000141">
        <property type="protein sequence ID" value="KAG8192300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6E1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="204" mass="23352" checksum="71E4B799323D1AD2" modified="2024-11-27" version="1">MNANSAVPKWPTFDCTSENSPANRLYVTELPENARPGIPSKGQKKQDCILKFDWYFSTNEGELFSKQFSVPKSGKLFSFKARSSPWMNAGKQVEVFLVNVDDCPQTVSVEYNAELRNPDWTKVKELRGCQEFNYVFKCLDLFRIKGESVEVWPPAEMGSDVGLIPRVYGIKGTLKVIKERVQDWKFVSGHLKELECLQLELNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6U9</accession>
    <name>A0AAV6V6U9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000139">
        <property type="protein sequence ID" value="KAG8192449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6U9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="104" mass="12404" checksum="D9266C33673DD59D" modified="2024-11-27" version="1">MFRVDRPAMFTTWTYKQAGHSIIDRGNRIRPEKHNRKNIQKITWRTNDWVKGFGEELESRVGSMTIADVSPAVAIRRVILLYENQEYRELHQQTELQHVQGHTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6V5</accession>
    <name>A0AAV6V6V5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000140">
        <property type="protein sequence ID" value="KAG8192387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6V5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="132" mass="14230" checksum="C0201CA094734342" modified="2024-11-27" version="1">MKSLSRSAYGQFKSCVSAPLLRNCGTKVHALLDHSLSYLVGRCSNTFYPLSYSCPTARPPPPMTSVKTTTPLPPPPSTEPISTTPEETPTTPVVSKARTIIYTMPPTPESRVSSATSLVASWIALLVSLLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7X1</accession>
    <name>A0AAV6V7X1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_009725</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7X1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000007">
        <property type="entry name" value="Calcium voltage-gated channel auxiliary subunit alpha2delta 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013680">
        <property type="entry name" value="VDCC_a2/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013608">
        <property type="entry name" value="VWA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF67">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08473">
        <property type="entry name" value="VGCC_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08399">
        <property type="entry name" value="VWA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043742336" description="VWFA domain-containing protein" evidence="17">
        <location>
            <begin position="31"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="18">
        <location>
            <begin position="266"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8192702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1091" mass="124711" checksum="05E5F5D3FFC93084" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8D7</accession>
    <name>A0AAV6V8D7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000143">
        <property type="protein sequence ID" value="KAG8192185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8D7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="165" mass="17389" checksum="3FBFA5BFBDA53739" modified="2024-11-27" version="1">MSSSNNSGSAGQSKASDEKASKAEKKNQQTTPTQEEQANQQANQANQQANQANKQANQTNKQANQGNKQANQDNKQANQATQHQQASNASRGPAKTSKKDDQNDKEATKTESSGKKSANESPAKASRGGQADEEAAKARSAKKESSSKSPAKTSKKGGKDDEEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8P1</accession>
    <name>A0AAV6V8P1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000134">
        <property type="protein sequence ID" value="KAG8192862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8P1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="8866" checksum="028AF147ECFD655D" modified="2024-11-27" version="1">MLSRDDIHVCGLTQSSGCPSNVYWCFLGAANSGVKGPHNSSRQPFHQGIAQPHAAPQPTTSRCKIPLNMGLDTRGFIGRMGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9E5</accession>
    <name>A0AAV6V9E5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000127">
        <property type="protein sequence ID" value="KAG8193234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9E5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="96" mass="11046" checksum="D921ED140D88851E" modified="2024-11-27" version="1">MKGDRPELGIHRRTTTTEGTLPAMWHKITNFFGGEGQKDGQPPRSHGRRNVETRRGRLHHDAKRRTQRESPAEQGVAVPFSLEMKMARPQVQRHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAH6</accession>
    <name>A0AAV6VAH6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000131">
        <property type="protein sequence ID" value="KAG8193088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAH6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:rRNA (adenine-N6-)-methyltransferase activity"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
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        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051720">
        <property type="entry name" value="rRNA_MeTrfase/Polyamine_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290:SF0">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="215" mass="24462" checksum="47145AB0B8D27CCB" modified="2024-11-27" version="1">MKPSQLEYILTTLDDFEVPDITLEQYATTPHIASYIFQQIEDHYDGIAGKVVADLGCGCGTLALGAELSGAGFCVGFEIDENTIKIANRNKKDLGCDNVDFIQCDVLELRNHTRWHKVFDTVIMNPPFGTKWNEGIHLQFLEAAFSLARRTVYSLHKTSTDKKIQKLAEQWGVKMNAIYEVKYNLDKSYKFHKENSKDISVTVFKFDIPEEIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAZ4</accession>
    <name>A0AAV6VAZ4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000132">
        <property type="protein sequence ID" value="KAG8193048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAZ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043832101" evidence="1">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9100" checksum="E56DE10F315FFAB2" modified="2024-11-27" version="1">MKYLFALVFCALLSVSFGVYCTSEEECEDTECCVAAITAQALGTGVCTPRGRVVMSAVPAQMTPVDENEVNSYLFLQGSLRILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBD1</accession>
    <name>A0AAV6VBD1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein unc-79 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_003015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000109">
        <property type="protein sequence ID" value="KAG8194070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024855">
        <property type="entry name" value="UNC79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696:SF2">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14776">
        <property type="entry name" value="UNC-79"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="828"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1567"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1649"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1695"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1947"/>
            <end position="2079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2096"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2192"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2257"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1241"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1572"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1591"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1653"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1699"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1711"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1746"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2098"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2192"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2213"/>
            <end position="2229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2231"/>
            <end position="2240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2270"/>
            <end position="2279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8194070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2915" mass="325442" checksum="7097B7A97A9D6424" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCV6</accession>
    <name>A0AAV6VCV6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000114">
        <property type="protein sequence ID" value="KAG8193838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCV6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043529423" evidence="1">
        <location>
            <begin position="40"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9324" checksum="31F3D5830E4AEC38" modified="2024-11-27" version="1">MTFPKNKCTNTMRPLGTVSWAPFCFLCLTAWCTLMGVCANEVSSTPEPVPCSISCDCIGPEFAIQADCSNRTLTSVPSDLTIGTVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VD82</accession>
    <name>A0AAV6VD82_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_013669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000112">
        <property type="protein sequence ID" value="KAG8193974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VD82"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043439942" evidence="2">
        <location>
            <begin position="24"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="14128" checksum="5A594FBB61781B7A" modified="2024-11-27" version="1">MHNIFSAIFVVYLGTSFVVNVLGSKQSDGGLNDNGYALQMFPKCIDFDLALAEKRKELIETGNMPECKVKNVEKCYFEELMYVKSQVTIEPSLECMQQLRDFAHGGSPSENEVDTSDEELQEEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF26</accession>
    <name>A0AAV6VF26_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VF26"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="126" mass="14035" checksum="445C90AD225F5023" modified="2024-11-27" version="1">MFFLLSSSILFRRDIFSSILSAISSFLPLTQHQHPIFLFLNIFFLSPSLASPLPLLYSECPPALLSISTQQNRFEPLGRGGRGLRWTTGSFAPPPHLPRDEWIYEPGGRRPAIGRRPAGPTFEGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGB2</accession>
    <name>A0AAV6VGB2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000077">
        <property type="protein sequence ID" value="KAG8195825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGB2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8364" checksum="8A9C1916F256B870" modified="2024-11-27" version="1">MTFGKDASWTFKTFKLGDVVLIGDKRCPRNMWPIAMVEEVCFGRRRKGPIMLDQDSIRQAQTTNSTSVQYGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHY2</accession>
    <name>A0AAV6VHY2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_017914</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000083">
        <property type="protein sequence ID" value="KAG8195620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHY2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000621">
        <property type="entry name" value="FLT3-interacting zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="495"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8195620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="611" mass="69620" checksum="7A4733E403784445" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKA0</accession>
    <name>A0AAV6VKA0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000059">
        <property type="protein sequence ID" value="KAG8197044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKA0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="390" mass="41506" checksum="FF59CBF97890AED6" modified="2024-11-27" version="1">MKETAASNRIHCASYCLKEDGCIGFGFDTNKTCTLLSVHMKENYCVSNTCVPRKDVKVYMSEAAATTTTTTETPTTTTTTETPTTTTTTETPTTTTTTKAPTTTTTTKAPTTTTTTETPTTTTTTETPTTTTTTKTPTTTTTTKTPTTTTTTKTPTTSTTTKTPTTTSTTNTPTTTTTAKATTTTKKAPTTPPPETTPTQPEISTMPPPTTPTITTPVPTMPTVKVSGKCAAGVKLMRGLHAKESFFDGKDMTLTNCFILNVPDPYVKGTARRIEGKVDKLAKCEANYSVTGYDFLVGEDKTLQKFTLVCEKVVDDHFHPESEKTVKNNDKTLECQGNSVITGLKVTRSSMLPKYTVTAYCKELKAQSDVGTPKAANPAAPKAANPAGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VL29</accession>
    <name>A0AAV6VL29_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VL29"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10454" checksum="4C7BF3A3829306E6" modified="2024-11-27" version="1">MPQPCCCATKPALNTGNNISHARRSLQMKKKSKQEMMGGSCESKKMESRGPPRADVETLKMMERRMREDKGECVSTTGRDLRWQRLSGNCFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLJ8</accession>
    <name>A0AAV6VLJ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Round spermatid basic protein 1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_007209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the round spermatid basic protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000054">
        <property type="protein sequence ID" value="KAG8197464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026306">
        <property type="entry name" value="RSBN1/Dpy-2/CEP530"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13354:SF11">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13354">
        <property type="entry name" value="ROUND SPERMATID BASIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1189"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1389"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1530"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1629"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="636"/>
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    </feature>
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        <location>
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            <end position="646"/>
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        <location>
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            <end position="657"/>
        </location>
    </feature>
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        <location>
            <begin position="1076"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1119"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1136"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1201"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1223"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1261"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1389"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1408"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1447"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1470"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1530"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1560"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1634"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1673"/>
            <end position="1682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8197464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1754" mass="194693" checksum="DA0322BAA47E4222" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLU3</accession>
    <name>A0AAV6VLU3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_012325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000069">
        <property type="protein sequence ID" value="KAG8196511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLU3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043608191" description="Thioredoxin domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="16"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8196511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="437" mass="50252" checksum="B20300A30533F314" modified="2024-11-27" version="1">MRFLPNLYCISIAVICFVGIAESNRVLELSDRFLEVRTNGVWLVMFYAPWCGHCKNLEPIWNQVAQSLVDTEIRVGKIDCTRFTSVAQEFSVGGFPTILFIKGHKTVEYRGDRERTDIVDFARRMNGPAIRHFTNCDEFQSLRKKKKVFFVYIDDSKLERNEPLKDNYSRIAEEFQTVMNFYSAPLNCLSQVEGVALPTMQSAFVCKDGSCFRYEEEMLETHNMSLHDWVNKERFPAFIKFTQGNFHQVMKTKKYLVMAVLEENQIGGLTLKMTEFREVLEAIAVNNKALYHEKFVFGWLGHPDIANSIAMDYLPIPSLIIVNSTNYQHHLPTLDENEKVPSPQKILELLDLVKNNQAVAYGGETLYYRMFRAFHGLSTALSGMYKGNPVLTLVLLGLPIGLFSVICYTTCCTDILEAADEEEETEVPFDERHQKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMK2</accession>
    <name>A0AAV6VMK2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000056">
        <property type="protein sequence ID" value="KAG8197315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMK2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8947" checksum="700126EB07EE8A26" modified="2024-11-27" version="1">MSLVMVEPTTDKVLFQVDNTRQRFRVNPTIKAAEKALILRLCLGVISSNSMLPKQVSCPFTISMERALDRSLLAAVYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMW1</accession>
    <name>A0AAV6VMW1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000050">
        <property type="protein sequence ID" value="KAG8197815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMW1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="9797" checksum="38BBD4013DC7EF44" modified="2024-11-27" version="1">MWMTLFINNTNNLNNTLIKGVAPVDGLATTGSANQPQIVNALFNNRTIAKSSRTTVDRLTSSEPNIKLPLVHYQRPSTIPDSPTVSYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNA0</accession>
    <name>A0AAV6VNA0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000053">
        <property type="protein sequence ID" value="KAG8197570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNA0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7530" checksum="3DEFFAD9D723F946" modified="2024-11-27" version="1">MEKQRTGIVPPGDVRQDLLRDQHLPPTGDRAPPKQEGNHSTQHLRHNSNRDCRLGKGLACSGVYRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNN2</accession>
    <name>A0AAV6VNN2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2970 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000056">
        <property type="protein sequence ID" value="KAG8197341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNN2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10836" checksum="20C74F21C144727E" modified="2024-11-27" version="1" fragment="single">MDHNTDFDFEEKINFAISISMNFLTGVSQKMTKKAAHSSAKYHKLTRTDDGFVDLQYQKQKPKIPWGGILLAVFLFIAGGLLIAFASLLFTGHINGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP62</accession>
    <name>A0AAV6VP62_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_020322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000047">
        <property type="protein sequence ID" value="KAG8197946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP62"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043921990" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="678"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="757"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="4">
        <location>
            <begin position="218"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8197946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="903" mass="101050" checksum="FC8F40B98260DCAD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VR44</accession>
    <name>A0AAV6VR44_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000030">
        <property type="protein sequence ID" value="KAG8199162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VR44"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="9898" checksum="6CA0CEF31B17E202" modified="2024-11-27" version="1">MEMPNMAITRGVIGDPLPLFEECLSAAEKVADRRLLAKGRAARRCRTRAVAEPGQMQCSGLFTISSRRNPVPGRSASATRHHSADIPAVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRR5</accession>
    <name>A0AAV6VRR5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRR5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="10655" checksum="7B4E2230A770CDCA" modified="2024-11-27" version="1">MSNDRSTLGYGFGEKHLAGPLVARQNVSNSQCFVPSPLEKTGKKLNPGEERKNGNLLDAEATNGLNDVTSPKLMGTRLSWNGYPAILEIVERDTQFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSA7</accession>
    <name>A0AAV6VSA7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSA7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="82" mass="9135" checksum="B1C2D957EE82DA2A" modified="2024-11-27" version="1">MVPDEFCHGFPHHRPVPDVPKHPDAPHSMSTTPKPPIKGSAHLPTRQDQRRQDQVLNSRNKSAPCALVPIRYTDVKGSTLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VU68</accession>
    <name>A0AAV6VU68_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000017">
        <property type="protein sequence ID" value="KAG8200249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VU68"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8231" checksum="AA685F76B6607B99" modified="2024-11-27" version="1">MCLLISERYHKNLAQGSDNAIKRIRVLTDMDHGIMKNNTLILLNCKEVPIPPEPTTHIPPTTCHTPPPRSIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VU81</accession>
    <name>A0AAV6VU81_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VU81"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="10088" checksum="A14A5A6187381F92" modified="2024-11-27" version="1">MSSEEDRRMNQLDGPQLIPKNNRLHEDQPDTHGILNSSNVVPPSVSLGITDSSDLVKVTARPRKGNQIQELRAQMSLELTWDDMPRLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUQ4</accession>
    <name>A0AAV6VUQ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUQ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8323" checksum="A0CD3D5D94CEA0DE" modified="2024-11-27" version="1">MVDYLGSPSSLNTKLFNQLGEDCDSRKKSARWRARITLTALGRDLLARNLKRWIRLEEELGGGICMGWWIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVC2</accession>
    <name>A0AAV6VVC2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVC2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="11612" checksum="2BDF9C4B5175D5FA" modified="2024-11-27" version="1">MASPICPLKSKGLPSKQTTPQKKKRKSKKRGWSKQSAVDRPIPRSPEGAPPSDGERRDASGAGLRSELCAVAEDSAPERPLVEKSYVLWERKGYRGWWSCSEGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VX52</accession>
    <name>A0AAV6VX52_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000010">
        <property type="protein sequence ID" value="KAG8201010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VX52"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14460" checksum="F0FF08E4D86D4E83" modified="2024-11-27" version="1">MIVQKIKQTPKIQTLTVYFFLYPLYSITTSRNSAHFPPPQQVKPAECSGHSFMTNKKKKIRDCISRRRMEMEKKSFLTMIRLGMEILFLSLLRGREMTTDVSIGYHSVKPSAYPWKCDIGPSVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXI3</accession>
    <name>A0AAV6VXI3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 20">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6 20">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 20">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">Mitochondrial translocator assembly and maintenance protein 41 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_000522</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Mitochondrion inner membrane</location>
            <topology evidence="2 20">Peripheral membrane protein</topology>
            <orientation evidence="2 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the TAM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 20"/>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXI3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028840">
        <property type="entry name" value="Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 20" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16 20" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR028840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8200439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="327" mass="37668" checksum="02F0A5675C8EB955" modified="2024-11-27" version="1">MSIPKYVFDAIISRFPKNYSLAFAYGSSVFPQSNKLVDNTAMVDFIFAVDNPSSWHKSNMEMNHNHYSLVKYAGSEFIKNLQEHFGAKVYFNTLVNVENRLIKYGVISTSNLIEDLLDWQTLYISGRLHKPVQILNKIENLELQSALKTNLQSALHSALLCLPETFTEEELYIKIAELSYCGDFRMYFGEDKQKVQKIVKNQMPHFKKLYAEELQLMPLLYWSQNKSIIEQDNSSATTLHHLFLLPKRVQHNLLVTWNRDGRFRDMEDVLQSVAHDPDCSEMVKKAIQNITLLPSITQSAKGILTAGVLKSIKYSSRKLKKMVKSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXL8</accession>
    <name>A0AAV6VXL8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_012821</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the rigid cuticle of the spider.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXL8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF235">
        <property type="entry name" value="CUTICULAR PROTEIN 73D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043608197" description="Cuticle protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8201762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19620" checksum="47A1EE32D40249B8" modified="2024-11-27" version="1">MFSGLLIAIVISAVTGQRQHVRDFQSNPYYDESPKPYSFSYSAPLEDGVGQSSRTESGDANGRVQGSYTINNDEGHYRIVEYVADENGFRANVRTNEPGTESKSPADVVFVSEAGPFSYNPVIRPAAVVPNPVLNTVPLVNPVVPSVRRTMYRRPVVPRDYQYRPNRYQNRRVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZK5</accession>
    <name>A0AAV6VZK5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZK5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="46"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="120" mass="13445" checksum="4D5333BD6E5F6A82" modified="2024-11-27" version="1">MKPINPLEIYEVEFNLNLLNKIWKRDTTPQVLRCSALETIYSVYPEEDWLRVYTDGSYSESCASAGSGVFSKLFFSASAGKNRTASDGEVEAIRIALEKLLDCLQKFQKVVLLSDSQAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W253</accession>
    <name>A0AAV6W253_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-disulfide reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_012797</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="12">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W253"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000190">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000004">
        <property type="entry name" value="Thioredoxin reductase 1, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006338">
        <property type="entry name" value="Thioredoxin/glutathione_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01438">
        <property type="entry name" value="TGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF7">
        <property type="entry name" value="THIOREDOXIN-DISULFIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="3 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="16">
        <location>
            <begin position="35"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="15">
        <location>
            <begin position="389"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="219"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="81"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8201737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="516" mass="56443" checksum="840D6F6949ABD7BE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TD95</accession>
    <name>A0AAV6TD95_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007369">
        <property type="protein sequence ID" value="KAG8155672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TD95"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="10792" checksum="5835B0292DCCF19B" modified="2024-11-27" version="1">MEVTEFAKECVTTPRPKKPSPGKWMTRQLWAYPGARTAEFSLVGVLPRSGGGGPRGFPVEGAGRGPGPGAATGGRSWGVVKILKWTLWDGKFGKGFPHGGPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEJ4</accession>
    <name>A0AAV6TEJ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005795">
        <property type="protein sequence ID" value="KAG8160610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEJ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8160610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13256" checksum="4C462B81B56F136D" modified="2024-11-27" version="1">MGQNTICFPNEDLDSQTVDAESSPIAEKVARSTTLRRDPVTRPDGTRTDIYYYEHNSNHRLRTLKEIKNYCERNNLEFNPDIFDFSGKNKFSGFVGDVDARSVAAGDAGSVNFTNCPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TH55</accession>
    <name>A0AAV6TH55_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004566">
        <property type="protein sequence ID" value="KAG8171010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TH55"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="20263" checksum="FB80F417685C9816" modified="2024-11-27" version="1" fragment="single">MDLRSSSMSDCMEASEENDAPESLRDANMSPEYKLKRLLARNCNVSIPCELCPTGSQPILFKHLRTHVSTTHGIRCHRECQYCFGYQKWQKGDVKFNVKVHEHRLQCATSLLKCYNPKSQVVCEKSQPILSEEHMEEETSEETEYSKMIALGQKRMKQLQNLWCDMKKQFDSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TH70</accession>
    <name>A0AAV6TH70_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004444">
        <property type="protein sequence ID" value="KAG8171086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TH70"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="9450" checksum="7598E56D1A12A1FF" modified="2024-11-27" version="1">MNSLNYSEILINLQSLKEVLLAILMRNACWMKEIGLFKRNAYQSRLLKIWRTGNLQNISTSQSACSKGKKRKDRKLLYAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TI37</accession>
    <name>A0AAV6TI37_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004080">
        <property type="protein sequence ID" value="KAG8171370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TI37"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="32" mass="3388" checksum="96731A56CB7C941C" modified="2024-11-27" version="1" fragment="single">MPGSPDVGFWSGNQYGRTSVKSISATPMDVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIJ4</accession>
    <name>A0AAV6TIJ4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003826">
        <property type="protein sequence ID" value="KAG8171562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIJ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="137" mass="15401" checksum="7B0ACE61250D3ACA" modified="2024-11-27" version="1">MDPRPRKGKFSQIPPQIGMSMQLLRGNWWSFFFDHRWNRMKICRGPFLSVPFGSFDGKRRELVSALVSGVFGKGLGDRSLKMFTSPPAFSGLSNTVFFVHATGDASFFFRWPVQDFGTPFSLDASHRRGVFGGGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIN2</accession>
    <name>A0AAV6TIN2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003735">
        <property type="protein sequence ID" value="KAG8171647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIN2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="129" mass="14677" checksum="6801DC8079993BC7" modified="2024-11-27" version="1">MVASHHWPLDQAHEPSVRTCGSSRTEQDYYRNESHQKSRHRRIKKQRRYERLAPRASYPCGNSSDTSCIKLVKSKGSIGLLSQSVFILKIKIKRAFALLLYARFLSSLSRLGTSALPFDRCTAPAKQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJJ5</accession>
    <name>A0AAV6TJJ5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003105">
        <property type="protein sequence ID" value="KAG8172107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJJ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="9617" checksum="83F8640883634256" modified="2024-11-27" version="1">MCASQWVFNKPGGAQESTGGGRSAAFGIPFPRGRGAPETAAFHLWKWRSLSAHGGTRKMVNYARTGRGQRKLGGGSVGGSDVQIDRQIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TM55</accession>
    <name>A0AAV6TM55_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002125">
        <property type="protein sequence ID" value="KAG8173040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TM55"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8084" checksum="D30ABEADDE11DCCD" modified="2024-11-27" version="1">MLTQVLVAVGGKDVRSILFNCLRRIMTHDVAEIISLSGKALPGYGSKHPFLQIELCKVLFVHKVQRMGILRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMF5</accession>
    <name>A0AAV6TMF5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Srp40 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002430">
        <property type="protein sequence ID" value="KAG8172736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMF5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8172736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="42" mass="4750" checksum="E0374D57C708849A" modified="2024-11-27" version="1" fragment="single">HEIPNLGAARGKQFRHEKTKKKKGNHSFGKIDTTSVKSILFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TN66</accession>
    <name>A0AAV6TN66_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002156">
        <property type="protein sequence ID" value="KAG8173006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TN66"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="123" mass="13905" checksum="8B68D2DA8023880E" modified="2024-11-27" version="1" fragment="single">MGDADIDAIPVDEFEEKVLVVDDERLESLMLIIKFVADLKSWVNQVHAKVKDLENFRLCFTALNLLVVPIVIALFLSYGAGDTITGCEALVKYLMFFSGGIGLPFYVYTAWEYYCHENQDNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNQ1</accession>
    <name>A0AAV6TNQ1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001930">
        <property type="protein sequence ID" value="KAG8173268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNQ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8143" checksum="4CB853B80A71C1DA" modified="2024-11-27" version="1">MLMSWSAFEALNANIELFGSEFSPVKDDVEEEPYTVALSNEISSIGNDTMIGKRRLFVQLQKEDETLKGAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPG2</accession>
    <name>A0AAV6TPG2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_024791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001458">
        <property type="protein sequence ID" value="KAG8173865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPG2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8173865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="9829" checksum="4135F7B363EB0011" modified="2024-11-27" version="1">MNYRLGALGFLSAMTSVYPGNLALSDIGKADEWVQNNIQHFGGDYGDGKANEKDRYPKYPMTIVGHGCGALAVSLLQMPTTYTREEIPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQH5</accession>
    <name>A0AAV6TQH5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001442">
        <property type="protein sequence ID" value="KAG8173898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQH5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="114" mass="12985" checksum="E85A80DA92E354F7" modified="2024-11-27" version="1">MLLSSDEEDFVPLKRKVKAEEGSRKKKAVKVDLNLSGSELPSTSKSTLPPFSIYLGGDIVVEVKPYRKENYIGFYRNTDGEIKNRFNINVKQVRTLKRAVESIIEHLESNDIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRB0</accession>
    <name>A0AAV6TRB0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001222">
        <property type="protein sequence ID" value="KAG8174424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRB0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="8162" checksum="DB2049FCE4D6BF1E" modified="2024-11-27" version="1">MILRFSSSFEDKVIVPLRNDEVYTRECVVVKEIWKINWKFFCVRKQTQFQSASRLEIGECFSIVQERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUH7</accession>
    <name>A0AAV6TUH7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_011606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has antibacterial activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001039">
        <property type="protein sequence ID" value="KAG8175278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUH7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043966936" description="WAP domain-containing protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="5">
        <location>
            <begin position="22"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8175278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="10162" checksum="FA61CB3FD08003E9" modified="2024-11-27" version="1">MVLQNITMKTTVIIFLVIALAVTVHAGLYCPMKPDIACATTGNTCCNDGDCKDGDFCCKEACGAVCKRPAEEETDGEKYDQNPEVCQKGVFTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVC8</accession>
    <name>A0AAV6TVC8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000962">
        <property type="protein sequence ID" value="KAG8175694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVC8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="193" mass="22247" checksum="AB31DD7F290A0082" modified="2024-11-27" version="1">MLNMQLAEPKRRFVKVFEEWSSKTTSAAGGSPAYWVQSVTKSGDVLGEVGRWPSNSFAHPNHLRISRVSKTLFSHCDTLRPTNTINHAYCLVPSVYLKAPSQRFPCDRILDYSFCNRPYQVLKRNNKIFTLQVRNKLQNVTIERLKPFFSIVPDSMKNNPPPFIGDYQLQDGRSLNFPFGWWIIAGIKYLMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVS0</accession>
    <name>A0AAV6TVS0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_012413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000916">
        <property type="protein sequence ID" value="KAG8176160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVS0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8176160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="461" mass="51739" checksum="7C36BB0CFFADCF05" modified="2024-11-27" version="1">MPALNNADGRPGSPRSSTPTSQRSYSLSDSDRKKTQLSLEAAKREIQKLHEIIQANINKATKNDQDACAKIKELESEIKLLHLAQTNFLNNAVHLKEAKCTLEEARTIELEDSTNKNKNLLEGTLQEKLKILEDLRIERTAAAQKDEANRKELLESTDGILAQASVLTQQITQIGTIEEKLAASISTFNHHPPPSLSAPTPLSTPPSVSSADKNRFDNIYVILVDQPSSSPLSLDAFQKQLNQASKEAKKPFRCNGTYTIKSGFKINLPTEEDQAIVADLLQSSPSLSAFKFKIPKKVKPQYIIKFTSISSAEDLAIDLVARNPFISKDTFRVVFSMKVKEDTHWIIETEQQYAYIFNPLFNVFIGLKRCTINEFISINHCKNCGKYGHTKKRCISTAPICLNCGKPEYDPAQECITKCFNCNELNNKLNRNEPTDHRTGNYRCPENMRQLRIARQKAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWX5</accession>
    <name>A0AAV6TWX5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger MYM-type 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000938">
        <property type="protein sequence ID" value="KAG8175952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWX5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="57479" checksum="75860D7DBD20B44F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWZ4</accession>
    <name>A0AAV6TWZ4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000869">
        <property type="protein sequence ID" value="KAG8176527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWZ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="152" mass="17465" checksum="B120094FFFA280A8" modified="2024-11-27" version="1">MNLRCSLITLRFPLKITNSSQEHSGIALHVNNGKQKRVIHNEIWNNSGKCHTLQPYHDSCRCSCLAALFINFHNCFVKHIRKYKSWLQLIPPRSAALKADLMPRSFKVPTRDFEYSILNFGRDTFTLIGLISFRSSLRNFVVSFFSSAPGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXE5</accession>
    <name>A0AAV6TXE5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000871">
        <property type="protein sequence ID" value="KAG8176513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXE5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="155" mass="16912" checksum="D21E0F5889258CE9" modified="2024-11-27" version="1">MEPNVTQSVQKEEKWPIPPAAILCLSIALYIVLIVIGLLIRKCLIARGICTDCFPKMKSESECCGSCGGCAQQCNWKVPTVDSCLDAICPAKQRVNCIEFLVCDWENVQCCNDGGTYTCGSGDYACTWETPKCDNINCLCCEISFRNGASPPPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXP6</accession>
    <name>A0AAV6TXP6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000924">
        <property type="protein sequence ID" value="KAG8176030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXP6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="6520" checksum="B49C7DF4F4AFCFF0" modified="2024-11-27" version="1">MGTELKHGLGTEGALGSTGAELKGGLETEGAFESTGAELIGGLETEGALQSTGAELEGGLGTEGPSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXQ3</accession>
    <name>A0AAV6TXQ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000849">
        <property type="protein sequence ID" value="KAG8176755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXQ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="332" mass="37782" checksum="582841CB664F634B" modified="2024-11-27" version="1">MVDQGICRISKSPWSTPLHIVSKASGDIRPVGDYRRLNSVTIPDRYQIPHIQDFSNALHGKCIFSKIYIVRAYFHIPIHPEHIPNPANSSTCASPTAHDPTTPSDNGPDLRTPAELSNSGQEIPPKLQGRQTYDVLAKELYGIFVEYEIQNKVSVATTDNGKNFCKAFRFEKAFQNEDLIMAAILHPRFKLDWLPEDRKDEGKRKLASLLSSHNRFSPEQEENDEGDFLFSKKEVTSTEDEAHRYLMCKDSCFSILHGFSTLTMYKNAKKEDILKCAAELEVEIPENPTILNLRKLIEETEIYKKDPGFVGDMIASLLRNVRKKLLMIISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYR8</accession>
    <name>A0AAV6TYR8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_028609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000862">
        <property type="protein sequence ID" value="KAG8176627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYR8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="120" mass="13288" checksum="5DB8F8AD92FE4ABC" modified="2024-11-27" version="1">MKENGPPYCTCAAEASPGSCKHIFAVSYALEEYSRLELYSAPTEKLQAWHQPTNVKVNPVSSQELFGKPSLKEAVGDVKYSALFSGPYNYQYIAVMPDYEEHLASHMPPLPALILTCNCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1Z6</accession>
    <name>A0AAV6U1Z6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Down syndrome cell adhesion molecule-like protein Dscam2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_017456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3Q5</accession>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000649">
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    </evidence>
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</entry>
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        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000641">
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    </dbReference>
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        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
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        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8179254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="624" mass="72049" checksum="70BF20F63FA36E81" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5M4</accession>
    <name>A0AAV6U5M4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">JTE90_007028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
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            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
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            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000599">
        <property type="protein sequence ID" value="KAG8179847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5M4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="181" mass="20845" checksum="DE6C4F32A3C44070" modified="2024-11-27" version="1">MLRVSFPWIPASVDLKAPVTKSPLSIHRAAKETNRLVISLGLEFLEFLLSLSLQEEGGGGLYGPEIYIYTKTLPLPRFHGYFSHSSRYLCHMLHPWLLNFLLSDVLIFRFQIFLLFFTELLLEERKKRGSLCVLSFPPPSISIPVPTCSDFYLQTGNLCFNENRTGHTEIHKQIIDLSFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U644</accession>
    <name>A0AAV6U644_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_026321</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000627">
        <property type="protein sequence ID" value="KAG8179421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U644"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="12"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="961"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="999"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="355"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="975"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1013"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1023"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="94"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8179421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1064" mass="120864" checksum="645A4D00F1A72A13" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6G0</accession>
    <name>A0AAV6U6G0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_006151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000641">
        <property type="protein sequence ID" value="KAG8179251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6G0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000052">
        <property type="entry name" value="Lysine histidine transporter-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF703">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="26"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8179251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="425" mass="46517" checksum="01EDD81107A93C74" modified="2024-11-27" version="1">MKNVEHVSSSEKELVHNLPNPSSKGYSLWLAAVYITSFMAGMGVLAMPHALAGTGWFGVILVCLACANSWYSSTILGRSWLILEERWGEYRGKFRYPYPAIGMRATGRPWMRYVVSVALHVSFIGISIVYLLLSAEIAESLTNNYITLEYKYWIIILAAILCPLSWFGSIEEFWFAAIGALATATLACVAILVAVLLQVPKETLPTYGDTSFSTASLAFGAILFSFGGAFMCPTIQNDMADRRKFHKAALIGFIGILLLYLPVTVVGYAVVGHSVPPNILDAIGKGTLRTVIEACLAIHVFLAFLLAVNPVAQELEESLNVKPTFNWKRLVIRSLIVGLNLVVAYAVPHFDKILNLIGGSTFTLLAFVFPPIFYMLLVRGEPLESEAREISVLEKLFLIQVVITGVAGGISCTYFAILDIAQAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7U4</accession>
    <name>A0AAV6U7U4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000582">
        <property type="protein sequence ID" value="KAG8180139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7U4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="392" mass="44657" checksum="4E793D9B5D589C8F" modified="2024-11-27" version="1">MHPEGRGRRHHPQFMGSWCFQMMPPGCLSTFLSQGTKCTKRCKFAGNWAFYLREIEEKLQSAERQNNAQVARNHRIASMEYAALCIQMNSQLYDAGDEALRNLRDDEDAVLPPGPPQDPPRRPHDQWPGDDIFGGAAPAQAPAAPFIPEAIAGPSRLTRPAQQPAAPCVPEAIAGPSRLVPAQPPAIAGPSRLAPPEPLVDEPVLLPRARSRSPVANRPRARSRSPIAGPARRRSPAPVRRQRRPRSPPRHMRSEKEEAAHEKKNKFAFLREALERARAQREQERLWRENPALRPTRRARSHRPPPDHQVAFMPDTVARQWRMEPQQLRRFPNVDRIPAPLRRLDFDFLPEVPDDRLPAARHQPPVRRSLRIARNQRYNYLGPNVGPEMRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7X2</accession>
    <name>A0AAV6U7X2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000556">
        <property type="protein sequence ID" value="KAG8180672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7X2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="66" mass="7638" checksum="85B33D41D57536CB" modified="2024-11-27" version="1">MIPTNPHHKTQQNHREILKGHHKRFLESSHPLLRTPKPTKFSRLNPTTLSLNRCQALSLKGLLLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UA01</accession>
    <name>A0AAV6UA01_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000564">
        <property type="protein sequence ID" value="KAG8180446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UA01"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="191" mass="21763" checksum="EB3EE4B2CD23BC13" modified="2024-11-27" version="1">MVCLHHFADEDVLRDAATYDEKGELVTAKLQQLRIKDGAVPSIFPNCSKYLSKEVIHRTSPETKRKQKENLQLSAVLNESLQTAALFEQEAFEDWDELNSCIKNLKVSSYWDIIKRDKCIIFLHISTDPSPVIEKSIVIDSSLKLTIHVEKLPLVKVGNFSLPFVCNNICDIEDILTTLENCVPFLNQLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAG7</accession>
    <name>A0AAV6UAG7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc finger BED domain-containing protein 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_024744</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000539">
        <property type="protein sequence ID" value="KAG8180996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAG7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8180996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="49748" checksum="FA448E2A6BE1512E" modified="2024-11-27" version="1">MSEFLFKGTIKPNKQNLLKLQVLSEQQSDDPSPITSPEIPTPPPNAGPFTSNPGPSTSNLGPSTSNTGPSTSNPGPSSTSNALKRPHAALDDYLDVVRPVTVNKSRKLDEQLLRMIVKEYRPFSIVESKEFVKLVHMLMPGYQLPSRKTISNGLLTAVYNDKMESCKKQLDAVNHVSLTTDGWTSINNESFAAIAARFIDADHEMRSMLLECSEFPASHTAQNLADGLLSACNTWGLSGKVAAVTTDNAANTVSAIEMTRFRHIPCFAHCLNLIVKSSIAAREIQAVVGKVKRVVKFFKKSSAAVTKLRDFQKQMNLPEHKLMQDVETRWNSTFDMLRRFNENKNPILATLAVVESSPDVSFHKDDWEIVDGLINYLTIFHSITVEVSTEKMVSISLLRFLYKFFKQHVEKCLLNCTLNQPLATMGKALLDNLVSRFDKLCQGQIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAQ8</accession>
    <name>A0AAV6UAQ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 94</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_016599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000536">
        <property type="protein sequence ID" value="KAG8181086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAQ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="969"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1077"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1109"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1155" mass="126352" checksum="51B22F9098838111" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UB75</accession>
    <name>A0AAV6UB75_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_008599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000548">
        <property type="protein sequence ID" value="KAG8180815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UB75"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000502">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="9">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8180815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="484" mass="54531" checksum="08096877B97F2B25" modified="2024-11-27" version="1">MSFRIVRNSRFRHVFAQPSKRDNCYDNIKITKSSWDSNFCAINPKFLAIVIEAAGGGAFLVIPLQKTGRVDVNYPLVSGHKGAVLDIAWCPFNDNVIASASEDGIVRVWCIPEGGLTRSLVEPAVELFGHQRRAGVVSWHPSANNILLSAGADCKVRIWNVGTGETIAQLDHPDLIFHCCWNWNGSKLVTTCKDKRIRVFDPRTGKLKVEAMGHDGAKPQKAIYLRNGHLLTVGFSRMSERQYALRKESAIADPIILETLDTTNGVLFPFYDPDVNLLYLCAKGDSNVRYFEITEEAPYIHYISTYQSSEPQRGMGMMPKRGCDVKTCEIARFYKLHSRGLCEVIPFTVPRKSDLFQDDLYPDTLADTPAISAEEWIEGKDADPILMSLKDGYVPQKKAELKTVTKSNILDNMPKKNNQTSNQPSKIEELLEEVKKLKTTIQKHELRIFDLEKKLDSRTGGQMNFLKKAQTNNHGEKHLMPDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBG6</accession>
    <name>A0AAV6UBG6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000537">
        <property type="protein sequence ID" value="KAG8181074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBG6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="220" mass="24645" checksum="528D621868F7A017" modified="2024-11-27" version="1">MVMSNDDHNDYPSTDSDNSIYLPSKIQDNARIHSIETSPIEIEKPKESLNEKLRSWVVKYKVKNNATNSFKRASAKAERLLETSAVSSDSPDEVLPIEKKSENAKRPARYSSNEAILLSEEEESQSIISSKKYPLPKLPCSYKKLPKKIMSKSRAISHGDSHQSALYSQTFLQSPGSSKQPSQAALQSIENKASTEKNQSALCISYFLLTYTYHLSPRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBU9</accession>
    <name>A0AAV6UBU9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000553">
        <property type="protein sequence ID" value="KAG8180736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBU9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="10117" checksum="F662037BF807788B" modified="2024-11-27" version="1">MSICIRNGNCQFLSQAIRALRVCNLRGMVLKQRLQVGWWMGNTPESHQKTTSSITVRMFFLVIESCLKKYTRTLSSNERGDAECRGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBW4</accession>
    <name>A0AAV6UBW4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neuropeptide F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_028280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000498">
        <property type="protein sequence ID" value="KAG8181742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBW4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001955">
        <property type="entry name" value="Pancreatic_hormone-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020392">
        <property type="entry name" value="Pancreatic_hormone-like_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00159">
        <property type="entry name" value="Hormone_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00265">
        <property type="entry name" value="PANCREATIC_HORMONE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043473527" description="Neuropeptide F" evidence="5">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8181742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="10072" checksum="1FDCEF391BBC9F41" modified="2024-11-27" version="1">MMGKLGMLVFSVTMVVALIVMTLPREGMANPSLEEGLDVAEAIRFLEKLDKYYSQIARPRYGRSTDSHRKSFPMAMRSRKFANEADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCF2</accession>
    <name>A0AAV6UCF2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_028270</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the COPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000498">
        <property type="protein sequence ID" value="KAG8181731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCF2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000140">
        <property type="entry name" value="Coatomer subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6 14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8181731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="296" mass="33941" checksum="B5C73789D6F2C72C" modified="2024-11-27" version="1">MANQATPDILFDIKNSFYIGNYQHCINEAQKLKFNNPDQQLEKDIFMYRAYIAQHKYGVIINDVSSSSPPELQHVQMLALYLSGNDDKKKDIVSALEKKIQTINPEDKVLPFIAGFIYYFEENYDTVLRLLNKSENLECSALAIQTLLKINRVDLAVKELNSMKETDEDSTLTQLCQAWVNLSRNGEKIQDAYYTLQELSDKYFSTPMLLNGQAAALIALGKYEEAEPLLQEALDKDPNYPETLVNMIVLSQHIGKSTEVSVRYLTQLKDSHHNHPFVRDYQAKEQEFDRLVKSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCL7</accession>
    <name>A0AAV6UCL7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000473">
        <property type="protein sequence ID" value="KAG8182247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCL7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="98" mass="11410" checksum="C9D2E2487785850C" modified="2024-11-27" version="1">MWEIKAPNYQNAAIAAVKDDSLVENLQEQIAQLSLQIGELNRKRFPNRRQFRPRSRSSSRVRRGAVNNAICYYHSKFADAAFDCRVPCSWHNRKNSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCT9</accession>
    <name>A0AAV6UCT9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MBT domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_017141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000477">
        <property type="protein sequence ID" value="KAG8182190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCT9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20097">
        <property type="entry name" value="MBT_dSfmbt-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20100">
        <property type="entry name" value="MBT_dSfmbt-like_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF104">
        <property type="entry name" value="POLYCOMB PROTEIN SFMBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="MBT" evidence="2">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="2">
        <location>
            <begin position="123"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="2">
        <location>
            <begin position="227"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="2">
        <location>
            <begin position="341"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8182190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55868" checksum="63F12C8B03C620C2" modified="2024-11-27" version="1">MTEGSYDWQKFLKKSNVEAVPVTCFKHVSMSKHWGPIKEGMFIEMKSSDCSECPPHSPCCFWVGVVIKITGYIGLVRWLGFDEDSSNDFYVNFCTEPHLHPLGWGAENGMPHVPPKCIEDKYSDWKDYLQKKIKSVPTISPDFPSRVEESKKSVIKRGMKLEVVDRNLISAVRVATVNKVIGGRLYLKYDGLPESDAGFWCHERSPLIHPIGWSQIVGHALRGSLEYAKQSLLKTLFQTHEPADATWEMFVPVPNPVKNMKFQPQMKLEAIDPLNLSTICVATVTEVLRNNYLMIGIDGMTEADGSDCFCYHASSPCIFWPGFCESNDLQLTPPRGYKGEFKWEDYFKKTKSKPAPKILFHRDVPNHGFQEGSFLEAVDLMDPRLICVAQVTKVVGRLLRIHFVGWEEAFDQWCDCESPDLYPVGWCDAMGYRLEPPRVVQEPCDSRKILKANTKNRRRRARMAFTVRKRHNVRDFDALSIKTEPVDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UET7</accession>
    <name>A0AAV6UET7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000466">
        <property type="protein sequence ID" value="KAG8182348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UET7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9987" checksum="BA2064FC37633A35" modified="2024-11-27" version="1">MVVSPKHRLVEARHIYSKFRRFVVDKSPLMPYAVLHASLSECPTIPVLSDWMPRLMLIQLRVPRASLDDKCSDFFRSLRCKGSDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGH0</accession>
    <name>A0AAV6UGH0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000444">
        <property type="protein sequence ID" value="KAG8182853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGH0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="33"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="142" mass="15813" checksum="C160E1F4137CB42D" modified="2024-11-27" version="1">MATNEQEKKNSPPEGEEAIAAAAVYNRQRNNKFILDSGATSHMCFNPDLFFEITTQIDSYITLADDKPAKITGKGCVRITIPDEECGTKTLKLENVLCVPELKTNLLSTSKCTRNNRVVVFDAREAKVILEDGSTLFRAERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI67</accession>
    <name>A0AAV6UI67_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_017089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000436">
        <property type="protein sequence ID" value="KAG8183001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UI67"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="11"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8183001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="456" mass="49575" checksum="AC1CBA10E98ABEFE" modified="2024-11-27" version="1">MPAIRNPEIKYTQADVDKAVEVARRAFKRGSVWRTMDASERGRLIYQLAALIKRDIDYIASLETLNNGKPYAEAYFDIECTIGCLEYYAGYADKFHGKTIPADGSVLSFTKLQPKGVCGQIIPWNYPMVMLSWKLGPALATGNVVILKPAEQTPLTALYTAALAKEAGFPPGVINVLPGYGPTAGAAISAHPRVDKVAFTGSTEVGKLILQAAGASNTKRVTLEMGGKSPLVIFNDADVDEAVEIAYNALFANMGQCCCAGTRTFVQSKIYDEFVAKSVAKAQKRVVGNPFDDATDHGPQIDKEQFNKILDLIESGKREGARLACGGSRAGDKGYFVAPTIFADVKDNMRIAKEEIFGPVMQVLKFETLEEVLERANETYYGLGSGVVTKDLNTALMFSQGIEAGSVWVNCYDHTTQQTPFGGFKMSGQGRELGEDGLHEYLEVKTVTIKIPQKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UK71</accession>
    <name>A0AAV6UK71_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000368">
        <property type="protein sequence ID" value="KAG8184611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UK71"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="154" mass="16650" checksum="373603FDB4AC1871" modified="2024-11-27" version="1">MLALTEVKQYLDGDKVNKLTKRIWFLESGLGDKQVLSTDINGNPFASRSSRSSNLASFVSSTLMDYSSGGGANDATKNKWTRRNNKGVLSENIAGHRGRDDIDSLLQFINSSDKKAKGGQVDQKKALVKSKSGCICSFAPPPVRVISPIDAKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKJ1</accession>
    <name>A0AAV6UKJ1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000364">
        <property type="protein sequence ID" value="KAG8184679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKJ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043585800" evidence="1">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="66" mass="7265" checksum="BE5C4671699B456A" modified="2024-11-27" version="1">MQAFRFLIFSLVLLFLAGGQVEATKGTRKAKSRTETPISGSALLSYNEEELRICPRGYGSLHCVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKU3</accession>
    <name>A0AAV6UKU3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000374">
        <property type="protein sequence ID" value="KAG8184428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKU3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="305" mass="34572" checksum="1C9FDBA2D5E804C7" modified="2024-11-27" version="1">MALNLIQGKLMSEQSNTSTTSLLEHTPEDFQFEPKLQTEVRRISSMDDISRFYRYFHLLQNNLGDIFTWQQYLNLMRPEQDILDVFNDKADQTIRKEMNTAPQKWDSVEEPKSSAQVFLDEKEMRLPKLNKTNAVISKPSKNVSEISMTMSDFRDLYGSQPGEESVCVLINSSTTSLKNTSGAMMKMYSKTKNPDQNINTTTDIISRLPSNGIECGASLEGWGPNKNRIQINEIGGGAIENCKEMKLKGPIEVKHNASSTTASAPRHNFSEQFFSGEGESIVLPVKVKKRPKRKGFFKILAKFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULD0</accession>
    <name>A0AAV6ULD0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_011071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000353">
        <property type="protein sequence ID" value="KAG8184937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULD0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="486"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="581"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="621"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="536"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8184937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="880" mass="99070" checksum="F6F92A23D7C9F38A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMF1</accession>
    <name>A0AAV6UMF1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000337">
        <property type="protein sequence ID" value="KAG8185365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMF1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8185365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10544" checksum="A40888C388FDA7DA" modified="2024-11-27" version="1">MGRSVKTLPNLVHRVARTLHFVIQLVEQHDIDGNGELDPEELMEVPFIQNAAKNFYESKDGSTPYLDGSEGEQEQEYDENRRMEINEHLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMG3</accession>
    <name>A0AAV6UMG3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_022382</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000335">
        <property type="protein sequence ID" value="KAG8185451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMG3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11428">
        <property type="entry name" value="bHLH_TS_NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000006">
        <property type="entry name" value="Neurogenic differentiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF163">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX NEURAL TRANSCRIPTION FACTOR TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8185451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="272" mass="30106" checksum="93105642681AC0AC" modified="2024-11-27" version="1">MTAETIRSPSSASTEGAHLRLQTPMQTSTSPDPRRPFLNGPGYASTSPVSSPNPNWRKKDVALEHYKTSTTPQDVKAEEEKDDNNNKDDKSKKKKRYTKSRSNRQRNPLQVVKVKKTRRLKANDRERNRMHNLNSALEKLRTVLPTFTDETKLTKIETLRFAHNYIWALSETLNMLDSKGNSSSGHFAKFGTEDGSNMDTNSSEGGVQPPPLYGYCSAPIIPPSPAWSSVGSPNPASSSSVQMSGSYVSTDFSEESCSGSECSNSFVKYESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMH4</accession>
    <name>A0AAV6UMH4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_001505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000360">
        <property type="protein sequence ID" value="KAG8184808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMH4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003834">
        <property type="term" value="F:beta-carotene 15,15'-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8184808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="532" mass="59909" checksum="2548EC90A45166D5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UN36</accession>
    <name>A0AAV6UN36_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Exosome complex component RRP40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_003242</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000326">
        <property type="protein sequence ID" value="KAG8185704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UN36"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000112">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000038">
        <property type="entry name" value="exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="11">
        <location>
            <begin position="163"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8185704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="244" mass="26567" checksum="08734CC67AABB4D4" modified="2024-11-27" version="1">MSTPTTTNTANLQTGSVVLPGDILLDVSTYADSNKKIIFGPGTKRFGDKIIITKCGVLKQNASNVYYVDNHQIRYVPSRRENVIGVVTKKGGDEAVVDIGSSEPAIVDLLSFEGATKRNKPNLKPGDLLYATILTACKDMEAELVCVDKYGKSVGFGVLPADGFVFNASLEYCRRLLLPNSRILKRLGKSIPFEIAVGANGRIWLKSKTLEKTMVLVQALIVLEFATTNEIESMCSELSTVNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQA8</accession>
    <name>A0AAV6UQA8_9ARAC</name>
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        <recommendedName>
            <fullName evidence="3">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">JTE90_005872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000305">
        <property type="protein sequence ID" value="KAG8186344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032446">
        <property type="entry name" value="SCAPER_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434:SF2">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16501">
        <property type="entry name" value="SCAPER_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="1289"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="297"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="642"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="778"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="957"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
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        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
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        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="533"/>
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        </location>
    </feature>
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        <location>
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            <end position="573"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
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        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8186344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1906" mass="214481" checksum="C98E91B745436BC3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQW7</accession>
    <name>A0AAV6UQW7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulation of nuclear pre-mRNA domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_014768</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Associates with the RNA polymerase II complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000294">
        <property type="protein sequence ID" value="KAG8186696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQW7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CID_RPRD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000020">
        <property type="entry name" value="regulation of nuclear pre-mRNA domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF40">
        <property type="entry name" value="REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="8">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="416"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="639"/>
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        </location>
    </feature>
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        <location>
            <begin position="826"/>
            <end position="887"/>
        </location>
    </feature>
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            <end position="224"/>
        </location>
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        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
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        <location>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8186696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="887" mass="99251" checksum="EDE2BA5EDB5F1C52" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6US36</accession>
    <name>A0AAV6US36_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000294">
        <property type="protein sequence ID" value="KAG8186648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6US36"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8180" checksum="F6D57ADF0B43843E" modified="2024-11-27" version="1">MGRISFLDLQRVLRDGVRQKFFITPSSDAEEEDAAKQRPNFTLHSTPTAPARKVFPCGFSQRLRTDLCAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USV3</accession>
    <name>A0AAV6USV3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_024095</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000287">
        <property type="protein sequence ID" value="KAG8186849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000555">
        <property type="entry name" value="Dumpy, isoform I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000526">
        <property type="entry name" value="Dumpy, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.20.10">
        <property type="entry name" value="Plasmodium vivax P25 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22963:SF39">
        <property type="entry name" value="DUMPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22963">
        <property type="entry name" value="ENDOGLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="93"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00286">
        <property type="entry name" value="PTI"/>
        <property type="match status" value="38"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="39"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043496202" evidence="12">
        <location>
            <begin position="18"/>
            <end position="6302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6230"/>
            <end position="6257"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="158"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="202"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="243"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="327"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="368"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="409"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="488"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="532"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="615"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="660"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="705"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="825"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="913"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="1000"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="1042"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="1161"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="1417"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="1457"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="1676"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="1886"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="1951"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="2303"/>
            <end position="2338"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="2550"/>
            <end position="2590"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="2887"/>
            <end position="2926"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="3059"/>
            <end position="3100"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="3128"/>
            <end position="3167"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="3321"/>
            <end position="3360"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="3422"/>
            <end position="3464"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="4486"/>
            <end position="4525"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="4659"/>
            <end position="4698"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="4831"/>
            <end position="4870"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="5003"/>
            <end position="5042"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="5238"/>
            <end position="5280"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="5428"/>
            <end position="5470"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="5496"/>
            <end position="5535"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="5617"/>
            <end position="5660"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="5807"/>
            <end position="5847"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="14">
        <location>
            <begin position="5931"/>
            <end position="6168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="6265"/>
            <end position="6302"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8186849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="6302" mass="679431" checksum="60D25B7E3BBC415D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UT35</accession>
    <name>A0AAV6UT35_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Papilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_005765</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has antibacterial activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000282">
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    <dbReference type="Proteomes" id="UP000827092">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050431">
        <property type="term" value="F:transforming growth factor beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Tissue factor pathway inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elafin-like"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_sub2"/>
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    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
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        <property type="entry name" value="Kunitz_BPTI_sf"/>
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        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
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        <property type="entry name" value="WAP_dom"/>
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        <property type="entry name" value="ACP24A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45938:SF7">
        <property type="entry name" value="WAP, KAZAL, IMMUNOGLOBULIN, KUNITZ AND NTR DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="70"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="138"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="217"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="13">
        <location>
            <begin position="359"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="410"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="541"/>
            <end position="630"/>
        </location>
    </feature>
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        <location>
            <begin position="636"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002878"/>
        </source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8186993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="75011" checksum="14FB3F0AEEC7347D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVJ9</accession>
    <name>A0AAV6UVJ9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVJ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF235">
        <property type="entry name" value="CUTICULAR PROTEIN 73D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043865669" evidence="2">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8188482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="209" mass="21536" checksum="31FF868F6E56E81F" modified="2024-11-27" version="1">MRFFAVPACISLLVVCTSALGYGGNGGMKSGNAGMGSGYESRNAMQSGYGSGSGTGSGFGGGAGMGFGGLGGYANSKPTPFNMEYEAADEQGNINYRREVGDGNGKVQGSYGYMDNQGLYRSVEYMAGPEGFTAYVKTNEPGTDGKENPADVVMNVQETPAGIVEKYNRRAQNNIYGQGFSSMGYGGSGMSMAGYFQSGQGAKSGKSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UW20</accession>
    <name>A0AAV6UW20_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_005985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000235">
        <property type="protein sequence ID" value="KAG8188632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UW20"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="226"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="304"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="388"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="459"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8188632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="575" mass="63906" checksum="45F2ABEC8370A2BD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYC1</accession>
    <name>A0AAV6UYC1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cGMP-dependent protein kinase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000220">
        <property type="protein sequence ID" value="KAG8189164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYC1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="12086" checksum="060475C7D00A1B46" modified="2024-11-27" version="1">MTLEVLADLTMGTVEELKEMVLKQEQDINQMKAMLIQKEDEIRQLRSLLDKYQSVFPVMSPQRYSRSARRKERAQGISAEPQSLRTIQEIIQAKFPEYPKSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYM9</accession>
    <name>A0AAV6UYM9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GTP-binding protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_005989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000235">
        <property type="protein sequence ID" value="KAG8188636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYM9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF43">
        <property type="entry name" value="GTP-BINDING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Obg" evidence="8">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="7">
        <location>
            <begin position="149"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8188636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40684" checksum="89718D989C3C7088" modified="2024-11-27" version="1">MVRLTSLLLRDSGRRTFIDSVRIFVRGGRGGNGLPKYGGIGGKGGDVYAEAVENYSLKQLKKEFPSQRFVAGSGGDSRRFQILGSPGEDYIIKCPPGVTACSRNIIGDLNRVGDKILLSRGGAGGNPQNGYLGQKGQPVPLTLDLKLLADVGFVGYPNAGKSTLLKALSKAQPKIANYPFTTIAPNIGMLCYNDLRQISAADLPGLIEGAHVNFGMGHKFLKHCMRTKVLLFIVDIDGFQLNTTSPLRNAFETIVCLNKELELYDEDLLLKPAMLAVNKIDTDDGEAKFQKLKDEIKYLDFNIKRLPEEMRPKSVVKFDAIVPISAKEGTNVEVLKQKIRTIIDIYQEQNVVRYLEEGPKDMDDAGVIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYV7</accession>
    <name>A0AAV6UYV7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000232">
        <property type="protein sequence ID" value="KAG8188726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYV7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="116" mass="12981" checksum="0EE0DE0F68097BD2" modified="2024-11-27" version="1">MHDIGGHGGGNGRIHFTPVHFIRAILIQEQGIRPNRRYDAEEISYFAIIDPDLLPAGAREIPQWGHLLKWFGGYWSSFDDGNTKSQTSRSKSISSPLEDQEVPAEIDVSLPLKLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZK4</accession>
    <name>A0AAV6UZK4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GST class-mu</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_019008</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Mu family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000224">
        <property type="protein sequence ID" value="KAG8188996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZK4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03075">
        <property type="entry name" value="GST_N_Mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000003">
        <property type="entry name" value="Glutathione S-transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000019">
        <property type="entry name" value="Glutathione S-transferase Mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003081">
        <property type="entry name" value="GST_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF222">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01267">
        <property type="entry name" value="GSTRNSFRASEM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="92"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8188996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="225" mass="26462" checksum="E1238EB5E67CA63A" modified="2024-11-27" version="1">MASLPILGYWNIRGLAQSIRLMLNYAEEQFEDKMYKYGPAPEYSRSDWTHAKFTLDLDFPNLPYYIDGDRKITQSLAIMRYLARKLELEPGTEDEKIRSDITEQQFVDFRTGLTRISYDINFDNLKEVYLKNLPQALKLFSTFLGERKYFACQDKITYVDFIAYEALDVHRLLSPECLDAYDNLKSFMDRFEALPTIAKYMKSKKFLKYPVNGDMARFASRSSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZL6</accession>
    <name>A0AAV6UZL6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000223">
        <property type="protein sequence ID" value="KAG8189011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZL6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9955" checksum="089CB9F0BD779F71" modified="2024-11-27" version="1">MLPISKWQPRSKGRRTRQCRPRNSSGIVEDRSKYPTRKGYLVLDIRKEDFEFRIFRHTHKRGLAIGDYVPYPLQLCVSLGSVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V067</accession>
    <name>A0AAV6V067_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000217">
        <property type="protein sequence ID" value="KAG8189358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V067"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7976" checksum="FF5FDD5C809A0D34" modified="2024-11-27" version="1">MQLQIKVVVILAIANLLYINRILPTMSSPITSMAGIVGLNVVLLFLKRFFQELSVIIETSFMFRDKSYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V072</accession>
    <name>A0AAV6V072_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000199">
        <property type="protein sequence ID" value="KAG8189944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V072"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029357">
        <property type="entry name" value="SPATA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14917:SF4">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14917">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15244">
        <property type="entry name" value="HSD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="467" mass="52892" checksum="BA3F2CE529C8CB30" modified="2024-11-27" version="1">MANSREFEGSFDDFFETGPSSDNLIRLSHLNNKSSVLCPEKPDITSQYLALQQLEAHQRMISRAKSIVDTSAPKSLQSYISVADRQRKKRWQRLNGSSKPVIENLNGSYQQLASSRLQTPFSEEEDNVSLNASTVNKCVQTGIPFEIASSKTADKISWYLEALKQGEIFHQPTDNSKNSSVHHNEKNSNSKVKKKVVKGDFMDRHEKCFVQPKKPFSPRILPNYSTKAKLKDMKCYKPPVSKKESVSSHSSDTFESYDNEEESEDDAQKSSSTSSVEEESHIKSPPQASARHSSFNQTYSQPLVPHQNREYFETSHNSDSLSRNEEDEYLDFLSKVTEDILRSGVYSDKAIRQSFEFHMQFYKDTSNKEKLQSLLNQVLEGLKISSDNSEETASYRNPLLINFSRPNTPPVKDSLEILLSTKNNPNDEAAASISTVQRLNFNSSLTDDDSINIHQNTLQDNVNSNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0B4</accession>
    <name>A0AAV6V0B4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_016623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000226">
        <property type="protein sequence ID" value="KAG8188956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATF7-int"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 7 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23210:SF26">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 7-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16794">
        <property type="entry name" value="fn3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1234"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
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        <location>
            <begin position="949"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="970"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8188956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1350" mass="147620" checksum="CE287B0BB00A1FFB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1B1</accession>
    <name>A0AAV6V1B1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Retrovirus-related Pol polyprotein from transposon 297</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_008108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000203">
        <property type="protein sequence ID" value="KAG8189797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1B1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="221"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="3">
        <location>
            <begin position="337"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8189797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="45955" checksum="985DA461CA43A937" modified="2024-11-27" version="1">MEECQQKNKTWYDKRAVKREFRIGDLVLIFATFKSNKLSPHWTGPGTILRKLSETNYVVQLPGEKATSKVYHVNMLKPYYKRPEEVNYLISDLEKENDEEQMEILCVDSNPNILDLKEMFQDYGESSNMNEDQIAEMKKLVWKYMKCFSNVPGKTELVIHDIELSEEQSILSKPYRTSPRQNAILKTEIQKMLDLKIIEIGFSDCTSPMILVEAPGKDPMPCIDYRNLNKITKTKFFPLPNIEERIEIVSSVQYITVLDLSKGYWQIPLTERAQRLAAFVTNFGTYKPLRMPFGLKNAPYEFRLAGYYGRYIPMFSSIAAPLTDSLKGKARKGPITWTKECEEAFDELKNCLCNYPVLYSPDYQKPFIVETDASDQGMGVVLSSWQTMKLKNTLLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2B3</accession>
    <name>A0AAV6V2B3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein UBASH3A-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000199">
        <property type="protein sequence ID" value="KAG8189963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2B3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30956" checksum="906A5024508928A0" modified="2024-11-27" version="1">MGDEQQPRKLYIMRHAERMDLTFGYGPAWMKKCFDEQDNYIRTDLNMPLSVPKRKGSQRDYIYDCPLTRIGLVQATFAGEAIKSRNVKFSHVFSSPSLRCMETCRKVLEASDQIHLPINVEPGLFEWLEWYVKEMPKWMSPEEMKENGFNVSEDYIPVMNETEILGRKETCEEYYERSFKVASDVLQKYSGKILFVGHASTLDACSRQLVGQQPKNEADMMKCITKLPLTAIAAVELDSGSQWKLIEPPILPPTHLKNAAFDWRILLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V337</accession>
    <name>A0AAV6V337_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000195">
        <property type="protein sequence ID" value="KAG8190066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V337"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8190066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="98" mass="10787" checksum="4044D03780E5C5A4" modified="2024-11-27" version="1">MPLIPLGAIDVALEVAFVCILKIIQTLVAMFNYVYGGELMLFPDGWSIRRSARRRQIDEARQDEEPGAARGVDEPDEVADTEGVDEEDEGFVSATEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3A4</accession>
    <name>A0AAV6V3A4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000187">
        <property type="protein sequence ID" value="KAG8190295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3A4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8728" checksum="B81DAE5BE2C593BA" modified="2024-11-27" version="1">MWNKLLPSISQIQVPPLNYRPGLLDHPAPVCCDTVSSLNKRISHAKLLTLVVQGGTSFYHPFHRYKFRHWTTDLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5B3</accession>
    <name>A0AAV6V5B3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclin-dependent kinase</fullName>
            <ecNumber evidence="3">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Galactosyltransferase-associated protein kinase p58/GTA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_010048</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000166">
        <property type="protein sequence ID" value="KAG8191124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5B3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000124">
        <property type="entry name" value="cyclin-dependent kinase 11B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="420"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="21"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="705"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="220"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8191124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="750" mass="87012" checksum="ABA2BECE32C730AA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6C1</accession>
    <name>A0AAV6V6C1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_014111</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000142">
        <property type="protein sequence ID" value="KAG8192254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6C1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF549">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8192254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31433" checksum="D9F80EC09F68B8AA" modified="2024-11-27" version="1">MIGVGIYLKSIFEQQRYMMPGFHYKKHTDFIIYSGVSLAIFHLIGSKICYDSGNYRTRSRFHSFMSGYMFLLLVAFALQMAVSISANSAVLSLKKGFPKGFLNAMASYESDPNKRRQVDQMQITHKCCGSSGYKDWLEISWYPEQFIRPELKDVNGRAVPFTCCDPSYRGPCLHDAASQNTRPGYLNDNEKGFFKKGCSHVMTHSLKKLLNNLSLWILLPMFMELVILVLVKYLHTSGVNADEDGTGFGYLMEACPCTCCECCEIDIHSIKKKPLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6K9</accession>
    <name>A0AAV6V6K9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_029102</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000140">
        <property type="protein sequence ID" value="KAG8192375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6K9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901029">
        <property type="term" value="P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000002">
        <property type="entry name" value="Putative ADP/ATP translocase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="111"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="208"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8192375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="299" mass="33027" checksum="F9EA544407CD80CE" modified="2024-11-27" version="1">MPIDVMSFAKDFLAGGISAAISKTAVAPIERVKLLLQVQHVSKQIAVDQRYKGIVDCLVRIPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKTVFLGGVDKKTQFWRYFLGNLASGGAAGATSLCFVYPLDFARTRLAADVGKGAANREFNGLANCLGKIFKSDGLMGLYRGFSVSVQGIIIYRASYFGLYDTAKGSLADPKNTPILVSWMIAQCVTVVSGIVSYPFDTVRRRMMMQSGRAKSDMLYKNTLDCWMKIGKQEGPKAFFKGALSNVIRGTGGAFVLVLYDEIRNFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7I9</accession>
    <name>A0AAV6V7I9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7I9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="9243" checksum="47979AA9DD5421BD" modified="2024-11-27" version="1">MIASTIIQLVRRCLKANTLQRYHLVPPDLYVRFPSRCSTGQGTSIAPWSDTASPYETVDATLPQSWHDTPDVLETEAGKLKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V927</accession>
    <name>A0AAV6V927_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_027768</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="EMBL" id="JAFNEN010000144">
        <property type="protein sequence ID" value="KAG8192121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V927"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06370">
        <property type="entry name" value="PBP1_SAP_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14042">
        <property type="entry name" value="PK_GC-A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000420">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000265">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000311">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043338929" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="21"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="537"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="20">
        <location>
            <begin position="880"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1064"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="817"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1071"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8192121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1254" mass="142030" checksum="CB6672E10B7A1C57" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9S8</accession>
    <name>A0AAV6V9S8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9S8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9945" checksum="AE0B3F3F2B4A9DBD" modified="2024-11-27" version="1">MLPLHPHVGDLILMILEERGGFIVPQLRMLFVSKGVCPHPHPKWEKKPSQARVLLTGVLRRFVPYIRVSWPLGEAPRTGKTTPHKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBZ1</accession>
    <name>A0AAV6VBZ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glutaminase</fullName>
            <ecNumber evidence="5">3.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">L-glutamine amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_003721</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000119">
        <property type="protein sequence ID" value="KAG8193509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBZ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:L-glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000069">
        <property type="entry name" value="Glutaminase, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.710.10:FF:000008">
        <property type="entry name" value="Glutaminase, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041541">
        <property type="entry name" value="Glutaminase_EF-hand"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544:SF29">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17959">
        <property type="entry name" value="EF-hand_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="13" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="15" id="KW-1053">Target membrane</keyword>
    <keyword evidence="9" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="Glutaminase EF-hand" evidence="20">
        <location>
            <begin position="109"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="18">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="621"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8193509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="649" mass="73442" checksum="C89AE3CD08ACA7DA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCR9</accession>
    <name>A0AAV6VCR9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000103">
        <property type="protein sequence ID" value="KAG8194434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCR9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9861" checksum="004FDBC36297B4D5" modified="2024-11-27" version="1">MRVMIHHGKFYCLSDSNNNKTCNNFTSYDLRHRLYQSVVPKIHQTKEDPRAIHLRASIHLLQCRLEQYGLKKADPCGLWPLVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDA2</accession>
    <name>A0AAV6VDA2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_011425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000113">
        <property type="protein sequence ID" value="KAG8193865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDA2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF7">
        <property type="entry name" value="SI:DKEY-228B2.6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8193865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="294" mass="33796" checksum="2C5D6391EE1FC404" modified="2024-11-27" version="1">MVTCTAVGCSNKPEMKIPGVTYHRFPTNLQMRQKWTLAVRRANWMPKKNSVLCSVHFENEMFNWSKSAEVGKKFLKRTAVPTIFDKKKFTIKQESLPSQTSTIPQLLVQVKQEPLAEILNDSGLAALLNGDTSGSFVPNIINTHEAIHNQTPMNNVVVISDCIYTQNILNSEGINDNRTLLVSDGTDLKTEWSSDDEEKQWVHSKNKPNKFYLKKYNHDPLILLSNDFIVERVQNLRKVISDHKKELKTLWQTSRRQNRKIDALRKELCKISRKHKSAVTRSSSPVVHFLQQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFJ6</accession>
    <name>A0AAV6VFJ6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000089">
        <property type="protein sequence ID" value="KAG8195389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFJ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7543" checksum="9313BEC153FE4525" modified="2024-11-27" version="1">MRYFRSIASTSGTDSNLLFLSTNIVLERVVPEYSTSFIVLRNKTRVTDSELATGFWIFGPHQISDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHU6</accession>
    <name>A0AAV6VHU6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000073">
        <property type="protein sequence ID" value="KAG8196259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHU6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8196259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="118" mass="13242" checksum="5592E3298740DC69" modified="2024-11-27" version="1">MNTDQKRVFEYLTNKLTGNDGVLRRFVSGVGENGKSFLIRVLKSWVKENLKKEAAVCTPTGIAIFNINGLTLHILLQLPIEHGDVQGYKSLNDDFLQNLRPDLGIYCSFSLLCSMHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIR6</accession>
    <name>A0AAV6VIR6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">26S proteasome non-ATPase regulatory subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_002182</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.</text>
    </comment>
    <comment type="function">
        <text evidence="1 8">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD2. Interacts with RPGRIP1L. Interacts with CRY1 in a KDM8-dependent manner. Interacts (via C-terminus) with phosphatase UBLCP1 (via ubiquitin-like domain); the interaction recruits UBLCP1 to the 19S regulatory particle where it dephosphorylates 19S subunit PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000084">
        <property type="protein sequence ID" value="KAG8195556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIR6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="10">
        <location>
            <begin position="47"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="11">
        <location>
            <begin position="849"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="613"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8195556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="905" mass="99543" checksum="5559886F679FA3CF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLV0</accession>
    <name>A0AAV6VLV0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IGFBP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLV0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043764735" description="IGFBP N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="11677" checksum="0CB0866136C80EE6" modified="2024-11-27" version="1">MRNCVSFILMIFVVVLMIVDARSPVKCASQCNTAGCPAVDCSCGTYKDECNCCDHCLTCADSTCSPLAGDVCVEGYTCAHPVGTEYMERMNGDGKCVPSHTVNAEGMFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM07</accession>
    <name>A0AAV6VM07_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM07"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="66" mass="7516" checksum="9853271EC2C6CDEC" modified="2024-11-27" version="1">MDRQLLSLIILTHSSDVLENSFALLSNDNYEVAMKSVLGFMLRLRRWKTLCGQCLLHSLNYCLIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNI6</accession>
    <name>A0AAV6VNI6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_007529</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNI6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8197283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="18717" checksum="E0F724E4D8272329" modified="2024-11-27" version="1">MKGFGGTWDLVCDRSWLPTFAFMFFGIGEFLSLPLYFYVSYKHGRRFSFFVFLAGECLFGGVTAVAPNIGCFIVLRFLLGLTVPATVATPASLAQELVGPKWRGQLCYCYPYGQALGGSVSCPVARSATGAQIPVLGAASMLPLSLLACTDVSGINLQYYILAMTNVAFQFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNX9</accession>
    <name>A0AAV6VNX9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNX9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="117" mass="13134" checksum="1FDFF9B88AFA9D6C" modified="2024-11-27" version="1">MPVNLTKQQKQQAFILQQHFILAVAAQLRIPSGVPTFPRSVSKCIYAEGLFPLLDIWIIGLSREFAGPFPQATWRGPLGTGARNNNFWFVTRFAPFALVRDAQFAWQSVDPIFDAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPK1</accession>
    <name>A0AAV6VPK1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPK1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="10634" checksum="D9B23BAB2D3D3028" modified="2024-11-27" version="1">MGNLGIRIPFVYVPARVVELGLASPEEASFLLAITGVCNVLGRLIFGFWVDRTTIKRQRLHVFNAILMINGLSHFTTVFIHKYYQMAIIVLLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS74</accession>
    <name>A0AAV6VS74_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VS74"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9807" checksum="7359BB28E6DC6D25" modified="2024-11-27" version="1">MSFGSFSKKRAAMMGVHLRSPSSSIMKAELFPRWINDFPCHASPKERLRAPQNQSLEPMKGNVSSKKRGELIDPIKQSSFTMVGRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT15</accession>
    <name>A0AAV6VT15_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000034">
        <property type="protein sequence ID" value="KAG8198918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT15"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7926" checksum="911831AF023C6711" modified="2024-11-27" version="1">MFVFHNADFQKWDCCRTLICTLMALILVILGLATSFILTHSGTPTYIAYAAGSSYYFMAFLVLWLYLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTA8</accession>
    <name>A0AAV6VTA8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000036">
        <property type="protein sequence ID" value="KAG8198731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTA8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7690" checksum="547748E0C74A1527" modified="2024-11-27" version="1">MEVPEVFQEFLNDSGYPEEISGGLLTENPFIGVPTAVILCLLCLLTCFGNAVVLHAIRTERRLQTVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTP8</accession>
    <name>A0AAV6VTP8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gem-associated protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_022116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000025">
        <property type="protein sequence ID" value="KAG8199663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056424">
        <property type="entry name" value="Beta-prop_GEMI5_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052640">
        <property type="entry name" value="Gemin-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056421">
        <property type="entry name" value="TPR_GEMI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46362">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46362:SF1">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23775">
        <property type="entry name" value="Beta-prop_RIG_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23774">
        <property type="entry name" value="TPR_GEMI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Gem-associated protein 5 second beta-propeller" evidence="6">
        <location>
            <begin position="358"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="597"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="640"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Gem-associated protein 5 TPR" evidence="5">
        <location>
            <begin position="805"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1527"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1579"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2071"/>
            <end position="2093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1528"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1538"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1583"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2071"/>
            <end position="2081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8199663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2177" mass="244754" checksum="C974957ACB2EB982" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTS4</accession>
    <name>A0AAV6VTS4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_006177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000022">
        <property type="protein sequence ID" value="KAG8199930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTS4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF82">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043372490" description="TIL domain-containing protein" evidence="4">
        <location>
            <begin position="16"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8199930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="158" mass="17706" checksum="BFFD63488F03418B" modified="2024-11-27" version="1">MQVLIFMLFVATVSATNHTCKHEHEHYNECGTDCPITCSNIQNPPQSCSATGAVCYRGCECDEGYYRQFGRYVGGCVLAKDCPPQNKFFEQVIKTGDTNGLSNLTTSSIPIVPENAENSTTTTSKPAARRTMDPKKLRRHHYVADEDEHLRHDLKHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUS7</accession>
    <name>A0AAV6VUS7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_021912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000017">
        <property type="protein sequence ID" value="KAG8200257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUS7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8200257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="272" mass="27017" checksum="B1EEB8572E8C3C26" modified="2024-11-27" version="1">MNFVEFFHHLGQILGLLGADNTTTTAVTTTEHFLKSSTPMILDTTTLQQFKSSTGTPYTVSTKFISSLGSVSPTGSTATVEDHSDNSTTTNSTAPATGSTATVEDHSDNSTTTNSTAPATGSTATVEDHSDNSTTINSTTPATGSTTVEDHSDNSTTTNSTTPATGSTASGSPSTGSSSTGSPATGSSSTGSPATGSTVTGSPATGSTATGSPTAESSSEKPTVAPTDKPSLSRGAVAGIVIGCLLAVAIIAAAIVFVVKQRNSPEARRLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VV76</accession>
    <name>A0AAV6VV76_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_006204</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000022">
        <property type="protein sequence ID" value="KAG8199958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051500">
        <property type="entry name" value="cTAGE_MIA/OTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23158">
        <property type="entry name" value="MELANOMA INHIBITORY ACTIVITY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23158:SF33">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043585821" description="SH3 domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="367"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="500"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="544"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="713"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1400"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="972"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1293"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="423"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="567"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="612"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="729"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1404"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1424"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1503"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1518"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1544"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1558"/>
            <end position="1584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8199958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1584" mass="177978" checksum="06349DDC2C2E9A81" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VV78</accession>
    <name>A0AAV6VV78_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_006228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000022">
        <property type="protein sequence ID" value="KAG8199986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VV78"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8199986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="533" mass="61739" checksum="E4D675D9F2EAE9FE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXB5</accession>
    <name>A0AAV6VXB5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXB5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="542" mass="58621" checksum="E3DD37649AA3BC38" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W0B1</accession>
    <name>A0AAV6W0B1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W0B1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="102" mass="11499" checksum="057C695F56EBE332" modified="2024-11-27" version="1">MAVCTRLSHQPKNGLVSNASLLQKLDVLTINSQNRKKRRSQFQLPKSGSENFQRFNLPAVHCTLKLQTCVEGLEKEFQRPSVSLSASLEHLHLRSSMLRAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W272</accession>
    <name>A0AAV6W272_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_011252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000004">
        <property type="protein sequence ID" value="KAG8201586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W272"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8201586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="350" mass="39631" checksum="C5A83BE1916BBE81" modified="2024-11-27" version="1">MSTEEKCPLSPEESKGLVWYIGYLFIFFLLFKIFRSLWRGLYSCFIADLIGKTVDWKKLDKWAVVTGATDGIGKAYAKALAAKGFDIVLISRTQEKLEDVAAEIEKKYSVKTKVIAVDVTGEIDIYDKIRREIDGLKIGVLVNNVGMSYAWSEYLTKVPNGEKFADNLVKANITTCLRMTLLVLPRMEQQGKGVILNISSLSACSVLLTIYSSVSALFPVPLLTIYSSCKVFVNFFSKATQEEYRKNGIIIQSVLPGFVATNMSKMRPSFTTCTPEAFVKWALKTVGVETQTYGYPVHKLQGYIQEFCGQYLPEDWYLSINHNMMNDLRKRYYRKYGMVDGDKMTSAKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TD38</accession>
    <name>A0AAV6TD38_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006544">
        <property type="protein sequence ID" value="KAG8155840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TD38"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="7617" checksum="5DE997813B609966" modified="2024-11-27" version="1" fragment="single">YEITAEFKHINKRRKKKQQDSLVTASEREKPSAESPARKGVGKGGVRSERAGDDSAASPLDGALPKVGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFB6</accession>
    <name>A0AAV6TFB6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005518">
        <property type="protein sequence ID" value="KAG8170410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFB6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46703">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46703:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9464" checksum="5F3FBE7EDDA2D165" modified="2024-11-27" version="1">MGQSVLRDREKSVPKRDVCRNANTCSCLSRCRPKGNGVNIPQPGHGDRSFGTKCGNATELGDVDGGPGEELSFLCKSSCPWNRLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFQ5</accession>
    <name>A0AAV6TFQ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005173">
        <property type="protein sequence ID" value="KAG8170591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFQ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="29184" checksum="6129DB001C2E8B0C" modified="2024-11-27" version="1">MVVILKRKVPYCVQDYFIALHHTKQQPPCHFPDIREQFEREYLPHLKEHEKLDYQRFTAGAVFEDQYDFPHGQCSPSHKTKHKKFAAAFREFKEESGFHFQMRNKEIDTLSMKKLNFIGCDGYHYEQYYFILENVVGLKRHSYFNTFGNSSTVENKIKSWNDDSLVYDGILLSIKEAYRKLLRQQHLKADGKHECLYFYVAPDPREATLCEQAEKVNRSQWYKKIEEWITRIQVSEPTSIRNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TG10</accession>
    <name>A0AAV6TG10_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005146">
        <property type="protein sequence ID" value="KAG8170602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TG10"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040379">
        <property type="entry name" value="WDR19/dyf-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920">
        <property type="entry name" value="OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920:SF0">
        <property type="entry name" value="WD REPEAT DOMAIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="10160" checksum="CC243A278388F0C5" modified="2024-11-27" version="1" fragment="single">DLQTFTIFTYHWAQTKKLPEKAVIMASAEQNSGTYKKAKLLLLGMHAKLKEKGMKIPIGMSQSLMLLHSYSLAKLHMQRGDHMKSAQNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGV5</accession>
    <name>A0AAV6TGV5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004656">
        <property type="protein sequence ID" value="KAG8170938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGV5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="239" mass="27036" checksum="9FE09C8A05FC7BA5" modified="2024-11-27" version="1">MKAQGSNENTTKTRILKRESEQFYSRQTIPHEPFDENSYSLQTNVAENIDVPQVTVAENIGAEESFNPQLESMQLYSRQTIPHELFDRNRESLQTNVAGNIDVPQVTVAENIYVSESSVPVETISNSQRESEHFYSRQAIPQEIEENRDSLQTNVAGNIVSQVTVAENIDAEKSSDTVETISNLQQEAFEKGLQIPSYVKTRDANEDISYEKLEKLLSILNQQLNDESSNVETTTGFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THF3</accession>
    <name>A0AAV6THF3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004253">
        <property type="protein sequence ID" value="KAG8171248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THF3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="276" mass="31828" checksum="74479129C884B7B3" modified="2024-11-27" version="1" fragment="single">YFRKFRLAVKMTEVQVFQKLNQEMTTLLMPFWSLYHPLTRKQYDLFLPTLKKHLEGEMGPTTSEWEGHWENFHQLILKGSDEFIWRRSYPEFVLLISERGDDWSPMLLPPETRMKLEVSLLGSAHLSPASQASFSSTPFTMATTSTSSTIAPFLMEPVGAAGGSNLGSLLPLGDDWEENPFLSGTLAKPPGTISSHITSFNRRYKDQRFSLEEQSPPFRFRLQMYDTAELDTPANWWKHKSLEMDVGYVENSPLQKTLQRIVNYCWKDYSADIGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TI17</accession>
    <name>A0AAV6TI17_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003906">
        <property type="protein sequence ID" value="KAG8171488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TI17"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="9799" checksum="4619FBE9D5C67A9E" modified="2024-11-27" version="1">MLTPVVSIAHVMAFHDLEMLNFCFAWLLLAAKQKFSIPGSCGGSAAAGASAPGPLNGGGSGDTTEIKSEVSRLSFWVLSINSPPSKELAVLPLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJ66</accession>
    <name>A0AAV6TJ66_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003429">
        <property type="protein sequence ID" value="KAG8171889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJ66"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="106" mass="11872" checksum="7C662B8587F54980" modified="2024-11-27" version="1">MKMYHSMVRKTVHMPNCRQVIQVETKRLKVVLELECNFEPVIVGDSQMLHRSANSLQQSSRHLFQGAGTHMQLKSCQTAGGLMCHPPRSTHAAQVLSNNNLAAMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKN2</accession>
    <name>A0AAV6TKN2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002921">
        <property type="protein sequence ID" value="KAG8172251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKN2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="9091" checksum="7B128FE433495FFE" modified="2024-11-27" version="1" fragment="single">IGNAINLANSLCKFPQECLRADPLSAYNAAYNSASLDKALRFEIDNAAHVLEKESIKGAEKFMKGVGRHGKFHLDSLDDKDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLR2</accession>
    <name>A0AAV6TLR2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_008969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002645">
        <property type="protein sequence ID" value="KAG8172514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLR2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043383760" evidence="4">
        <location>
            <begin position="25"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8172514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="248" mass="28661" checksum="41A38D60990D01F3" modified="2024-11-27" version="1" fragment="single">MIRISKRKHIFHLIVLLTLSTTVAYRDSICEENNLGIFCSCDTKYSTGETSIVCYITDPPTVQNEMWQSLAKVEKMFNLKLNSFSPEKKLDYVPTDSLQRMESLRYFTIEQAASLGYINSSTFSNMRELRELQLEDNGITQLGEGAFSNLPMLKKLALSSNLLQELLVDSFKGVDELEHLYLDRNNISRIEGCAFCNLQSLRDLELYGNSLTDLTEYMFRGLRYLKRLDLYKNKISILNDRVFQNLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TM64</accession>
    <name>A0AAV6TM64_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002279">
        <property type="protein sequence ID" value="KAG8172885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TM64"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17031" checksum="19EFC6350BFF01A5" modified="2024-11-27" version="1">MIGKLILKLKGKDWKTANSRIFDVEVSFDDLLSQADHGLQNLSFEVLDITTPLESYFGKENMPDKDILKELFGKVINNSFEFYGGKYPFGNDFENIFGKYHRAMTIKGGSALFLGASKLDHSCVPNAVYHATGASITVRAIRTIKKFEKVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TM91</accession>
    <name>A0AAV6TM91_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002424">
        <property type="protein sequence ID" value="KAG8172743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TM91"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="158" mass="18057" checksum="CD5ADD9F4D431289" modified="2024-11-27" version="1">MSAESKVLAVSKYSDKKRNFPLTSTTNQKDPATGCGLRHAANRCPAYKQKCRTCKRIGHYAKVWRNKKTVEETEARETSPEESLVFVAEMKRDQHNQDWYEELTFRNGCKIKFKLDSGAQYNVLSKKYARNINAKLHGSPIKKLVSFGRNTVPVLSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMR2</accession>
    <name>A0AAV6TMR2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002090">
        <property type="protein sequence ID" value="KAG8173072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMR2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="1">
        <location>
            <begin position="22"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="156" mass="17860" checksum="8620ABF7598F9033" modified="2024-11-27" version="1">MAVRVSAHRFRIAAGIRLLLPRPRTAQEGFPIHFHLIIICMNLPQAIKEFSLQTYIEERWTDWRLNLSSYVGENAIKFPQILVQHLWVPDLVFDNAKSGVLFDVSVPNTYVVVCEDGSLGRTSRYNLVISCQMNFLILSNGHAILFYKIGTLIKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TP33</accession>
    <name>A0AAV6TP33_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001514">
        <property type="protein sequence ID" value="KAG8173730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TP33"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="183" mass="21369" checksum="A3E6C0C0B7D9C65D" modified="2024-11-27" version="1" fragment="single">TQSCLECVTNNFERYNEAFLSSEDSTMQQNLLFLQLTFTPDLIKNLGIKEMLCDAYLEFLINEHLKELDIGCFLRNGCSWKCIENRIAVVGHLFTKVVFDLESWTYPCKFSFLFLSHLRNVEVLHIPHLCNDTALFCIYISCTKLLELNIEHSHDITEESLKLLCEKHKNKPECLIKILSMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQG1</accession>
    <name>A0AAV6TQG1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001493">
        <property type="protein sequence ID" value="KAG8173784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQG1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="147" mass="16178" checksum="7D9B3A5A564D0CF9" modified="2024-11-27" version="1">MEKFRENDIDCRALKELNEDDVSSFFSTLGQRLRFCSGLKSLHPVVQPVVLGIGPDTPDCILTDISLSSSDLGTTSCSSSANSLSYERVPLAQSTPSKQVTPSASSPLRSSPRIKARTFKNFLEQPKMKHARRIGETSSRIFSSLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRX3</accession>
    <name>A0AAV6TRX3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001212">
        <property type="protein sequence ID" value="KAG8174458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRX3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF6">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16839" checksum="C698D641B428F6E9" modified="2024-11-27" version="1">MMRSVLREHYWILGGCHTIRAVIKQCQACRRFKAKKLETVPNPLPEDRVREAKVFEVLGMDFAGPLYVKTGAKMSQKVWICLFTCAVYRAVHFELISSLSTDAFLQGFRRFIGRRGRPALCIVTMLPTYWEPPMLLTELIGMDKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTW2</accession>
    <name>A0AAV6TTW2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_009162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001092">
        <property type="protein sequence ID" value="KAG8175026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTW2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8175026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8400" checksum="D79F45B259D97873" modified="2024-11-27" version="1">MQQQSLFDLKKLFSIVGPVSYVKTVMKKKTRGLEGDGFENSYCSKKALERLNGLEVAGRTMKKDRLTDRTAIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUK5</accession>
    <name>A0AAV6TUK5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000980">
        <property type="protein sequence ID" value="KAG8175615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUK5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="155" mass="17070" checksum="ACACF745BF49B988" modified="2024-11-27" version="1">MTQFGLLCAHHTTAPPSSWNVPKDFPDPERSRGLHRQTEASLCLEGSRQRSHSSQTTRPNQSTPTDGYPSSEPQPADGRRPSSEHQPVHPGGRRPGNKPQPGFPNSRPSHRPKDPPLCISHRNNYHSRRHLPADPDSKDVKLPKSPSTTCSISAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TX11</accession>
    <name>A0AAV6TX11_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000910">
        <property type="protein sequence ID" value="KAG8176208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TX11"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="213" mass="23130" checksum="626974A4EBD1E2D8" modified="2024-11-27" version="1">MSTLRDQVNITFQELKTAIATHFTPCITIAQGISKLTSAIQGPSESVQDFAVRVEGLAKSTNAPADFTTQLIFSQFISGLRQDIKTQIHIQNPRDFTEALQTAIRVEKAFKDITQNVNSLEASASAATRAHESDKNAFITVIEALNNMVDSLAKQKPAERSSIVSSAANKAIAYKTVSGATAKTCLRDNSTKCRVISPTHPHLFNMGIHQTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXY4</accession>
    <name>A0AAV6TXY4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Retrovirus-related Pol polyprotein from transposon 297</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_024247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000864">
        <property type="protein sequence ID" value="KAG8176586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXY4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tf2-1-like SH3-like" evidence="4">
        <location>
            <begin position="45"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="227"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="3">
        <location>
            <begin position="348"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8176586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="51685" checksum="F893BF8D0CC49545" modified="2024-11-27" version="1">MKRCQELAISKMEECQQKNKTWYDKRAVKREFRIGDLVLIFATFKSNKLSPHWTGPGTILRKLSETNYVVQLPGEKATSKVYHVNMLKPYYKRPEEVNYLISDLEGENDEEQMEIPCVDSNPNILNLEEMFQDYGESSNMNEDQIAQMKKLVWKFMKCFSNVPGKTELVIHDIELSEEQSILSKPYRTSPRQNAILKTEIQKMLDLKIIEIGFSDCTSPMILVEAPGKDPRPCIDYRNLNKITKTKFFPLPNIEERIEIVSSAQYITVLDLSKGYWQIPLTERAQRLAAFVTNFGTYKPLRMPFGLKNAPYEFRLAGYYSRYIPMFSSIAAPLIDSLKGKARKVPITWTKECEEAFDGLKNCLCNYPVLYSPDYQKPFIVETDASDQGMGVVLSQLADNETEEHPIIYLSKKFTSVEKRYSVKRESRVFQQSSTPCRNSPCESMRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYB6</accession>
    <name>A0AAV6TYB6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_022059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000861">
        <property type="protein sequence ID" value="KAG8176638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYB6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8176638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="8238" checksum="B3D4618A439A7CB7" modified="2024-11-27" version="1">MSILTSQSYEPGDLIYSEEPFVRILRHDLWDKVCAGCCEYKKGLKKCSACSVMRFCGKNCQKKAWIDHFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYH6</accession>
    <name>A0AAV6TYH6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000849">
        <property type="protein sequence ID" value="KAG8176734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYH6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47456">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="34541" checksum="DD4B6424525F6F02" modified="2024-11-27" version="1">MANLMKSKIKKGEELAGQIVYRYNLPDQERHKNHVCGAAAACTEAIDPQLKVKIKELVFQGQRNLAVIATILEQYVVGELGETDRMRNRFFPIKTNVGYQPVAVIITQYETKEAILEALIVVKEWNPEIVPKFGMVDFAMEEILALELAFSGIKVFICTFHREQAWTRWTSKAVNISEPRAEALEKLRAIGNASNFQELEGAIENLQKWDYYEGSPLKLYFERTWLPEIERWTLVNKPPGLLFHTNNGVERINEELKYRYLMENKNCSLSGVMNVVVTEFLPDHYKLYITKNVKMLNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYM9</accession>
    <name>A0AAV6TYM9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Blimp-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_024798</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000833">
        <property type="protein sequence ID" value="KAG8176978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYM9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19187">
        <property type="entry name" value="PR-SET_PRDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000748">
        <property type="entry name" value="PR domain zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000833">
        <property type="entry name" value="PR domain zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000132">
        <property type="entry name" value="PR domain zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000211">
        <property type="entry name" value="PR domain zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000436">
        <property type="entry name" value="PR domain zinc finger protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016608">
        <property type="entry name" value="PRDM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044413">
        <property type="entry name" value="PRDM1_PR-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF59">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013212">
        <property type="entry name" value="PRDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="65"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="638"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="242"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="312"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="478"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="856"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8176978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="889" mass="100479" checksum="00D7924FD9A1DE37" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U005</accession>
    <name>A0AAV6U005_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000757">
        <property type="protein sequence ID" value="KAG8177727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U005"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="193" mass="19821" checksum="6C2B621D60938E4E" modified="2024-11-27" version="1">MASAALMDIAVGTVGSVAITNAVPLDHSVVVINAVRLCLSAVLINAVCQDRSAVVTNVVWLGRSAVVTNAVRLGLSVVEAAVVRLGLNVAVENAVRLGLSAARTNAVQLVLRVVVTTAVGLGLSVVVTNAVTPGHIVVVTNAVRLALLVVVTNVVRMETIVVITNVVSLNIVAVVANVVRKFRDVGINTEGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0A4</accession>
    <name>A0AAV6U0A4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aryl hydrocarbon receptor nuclear translocator-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_018992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000761">
        <property type="protein sequence ID" value="KAG8177685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0A4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11391">
        <property type="entry name" value="bHLH_PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="102"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8177685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="944" mass="105539" checksum="BB05965AB714AF22" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0V9</accession>
    <name>A0AAV6U0V9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_028310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000771">
        <property type="protein sequence ID" value="KAG8177589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0V9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8177589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="314" mass="36344" checksum="7766C68C3BF4DEE4" modified="2024-11-27" version="1">MASQFVDGFQIPAMFSVEAFRSALKYKPRDDDIFIVTYPKCGTTWAQHILALIFQQGEPLGEDWNFLSASPFLELLGAESAETMARPGAIKVHLPFHLTPWSDKAKYVYLTRNPKDTCVSFFHHVTSNPAHGFNGTFDEFFEIFLSGKNDYGDYFDHLLGWYEHRNDNNVLFVTYEEMKENPHQAILKIAWFLDDEKYAEPLRQDRKKLENIVKHSSFKEMKASLNVRMDQLFNMSSEDAKNAGLPKGMVDMASKMESLRVSGESPTKPCNFARKGIIGDWRNFFSEDQSRRMDGKFAERTKGTKIENFWKEYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U118</accession>
    <name>A0AAV6U118_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_029443</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000714">
        <property type="protein sequence ID" value="KAG8178137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U118"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052391">
        <property type="entry name" value="E3_Ligase-Neurotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133">
        <property type="entry name" value="ANKYRIN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133:SF40">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="8" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="9" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="214"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8178137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="497" mass="57000" checksum="24AFDF6C3B343DBE" modified="2024-11-27" version="1">MSARENLFSWKEQVRFVEGKGMVLNLKTFQLFQTDRRGDTPLHKLLSYCKLNETTLRQILDKGAPVNAQNHFGMTPLHCALSEKINCELPILRLLVDRGADVRMEDHQRRCSSYFAAGNKNISIEILEFLSERGADFHTRKKHIKSQSVLDYAIKRMQPSLDVIKWLFEKVADVSAVNEYGDTTLHLAALFHRKDVIELILKKQNIDVNLQNSNGDTPLHRVFLLSFNEFHEIQFDIVKILLEAGADANKKISHGEGALHLAAASGLCNPSVIKLLLDYGANVNESNTNGETPLELAVNNKKSSRAVVKILLDAGAIIIKEHPPFSNANNILHSAIKIYQDQLRNQHLPQRSEEVGKIVILLLKYSLLERPDTSYHLLQLDEEILRILKVFEEQCHQELNKPCPKFLKLAQLFRYCRLHKDLPRHEIITMLFNNCCPIYKDVLEGLMKRKDLEEVFKSYVIYVDKNPDERIVLNYDVTCNVMQYLTENDLLNLLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1I4</accession>
    <name>A0AAV6U1I4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000737">
        <property type="protein sequence ID" value="KAG8177914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1I4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="13859" checksum="01BFC1694B82B7EC" modified="2024-11-27" version="1">MGHAIGQATTSQKGFVPLHTYMPDYTYNTSNSVLQIVTGSCSVCYFVPVGIIDVCNFLIIRAANRSGKKNNQPMFVRRHSDFYIQEYDCGGGHLTLTTSASEKFSNSPILGLVEKMDFRSANRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2X7</accession>
    <name>A0AAV6U2X7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000684">
        <property type="protein sequence ID" value="KAG8178575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2X7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="205" mass="22724" checksum="FE3C12305D057D2E" modified="2024-11-27" version="1">MFLLQTQHRHHISRSTEPVLRDPNLHERYTSLVHKHHSGFQASRSPQDLASRHTFAAQVYNAHRISQITICSYFRTPTPTPPSPDSTEPGLTQQSVPKTGSVPQLQSSAPNSIPGNSLPGQQTSPSSQPGGSIKFLKYLFAYRWKFSISTQQSSFDNIPALRSPEPQSSTISEPISNSQPNLKQPSPQSTTVDFKRAGSPQEPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3V4</accession>
    <name>A0AAV6U3V4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_011612</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000675">
        <property type="protein sequence ID" value="KAG8178684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3V4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025754">
        <property type="entry name" value="TRC8_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF191">
        <property type="entry name" value="RING FINGER PROTEIN 145 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13705">
        <property type="entry name" value="TRC8_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="561"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8178684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="623" mass="70785" checksum="5F362FA86D2798D2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5V1</accession>
    <name>A0AAV6U5V1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_026304</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
            <location evidence="9">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000627">
        <property type="protein sequence ID" value="KAG8179404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5V1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.20:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8179404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="967" mass="111449" checksum="48FD9E7D1D09A202" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U680</accession>
    <name>A0AAV6U680_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_012544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000647">
        <property type="protein sequence ID" value="KAG8179135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U680"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043439918" evidence="2">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8179135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="157" mass="14342" checksum="7440C8E9CBED53B1" modified="2024-11-27" version="1">MNPALFAAFLVVGVACVAFAEPIPVAGAGGGPGGFGFGGGAGSFGRSNGGAYAGSNGGAYAGGNGGAFGRNNGVPVGLSNGGVFGGIGAVPSFFFPGFPGLEGYNGAQANAGAIYPPPPPLAADAGSATTAAGPTSNGVDTTPAADTTAAAGTTPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6C3</accession>
    <name>A0AAV6U6C3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000643">
        <property type="protein sequence ID" value="KAG8179184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6C3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8179184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="275" mass="30796" checksum="D5282A55C3A6CCDC" modified="2024-11-27" version="1">MPSDAEDQDGDSTDLAMENTGTGGSSQNGLNILATTASKFMINIKILVTSLNNRVNQEARKLNQKDRSDLLELTGKVLLTCMQAEAEFILSDGKIKDLEELIANKDKKIFDLQSQIANSDVTLETIDGKLQRLIETYQDNQKLINELLNKLPEGDTSDISAKNLKIDEAPVMVIDTNDNATALSYRDALMARAPELNIPNPMDLVIPRANRLIVKMRDTSNLEKFKNIIDNDPNLNKLALAKISKCRKDRLILFGPQHKLQRQHIYTNKLSLFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6N1</accession>
    <name>A0AAV6U6N1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_005263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000622">
        <property type="protein sequence ID" value="KAG8179518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6N1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043775807" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8179518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="46616" checksum="FD055538CF2B340B" modified="2024-11-27" version="1">MQSFLLLAFLCLGNVLADDSRMETVVAVTRCRASCLDQHAHVIRTEENCQKNPSCLMCWETCQMLHEHFEIWGIMCSVPDVCFPGCKTACQSLSYRSFLNETEFTPITINSVYDLSTSRVMLKWLPLDNEGTVLYTVMFQDSTQEWHQVAQTTLNVIHVKANLVGRETTIRVIAANATNQLSYSETTFVSSLVLGTKHAAFIKDNNWSPQLVSLERDETSTGILATITWPELPDEMGPLEYEVSWNVVDNTMITGHLLTTKNMAVITLWPDSIHLVTVDRYKSAGIIFGDSSQALVINTKVPVLNSKVSKSTDDLCKKDKVEVRTVIYYWIISFLSLIIIVIFIYGRMKGQIKNYQDKYSNQVSLMLEKSNAFRQLLQDQVAKKFTKTAPSQDSVTKCDAKIVKDIQNFQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6Z9</accession>
    <name>A0AAV6U6Z9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone-lysine N-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.355</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_007368</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60276"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.355"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.355" evidence="11"/>
    <dbReference type="EMBL" id="JAFNEN010000610">
        <property type="protein sequence ID" value="KAG8179638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6Z9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140949">
        <property type="term" value="F:histone H3K9 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10542">
        <property type="entry name" value="SET_SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011381">
        <property type="entry name" value="H3-K9_MeTrfase_SUV39H1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009343">
        <property type="entry name" value="SUV39_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="14">
        <location>
            <begin position="248"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="13">
        <location>
            <begin position="311"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="15">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR009343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR009343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8179638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="461" mass="52463" checksum="04D46FE91B2EBC67" modified="2024-11-27" version="1">MNEPRKKKLSDNDVTDSKKYLRQVNWINKDVEVGGRMAKDSHKGMKLKETDLEQLDIDIILDHKVFEDQIFYLVKLKTQSLKYSVWLSAGKVTGHPSILYYHQVFMNSPEGLDERIISFFVHDIVTREPHDLLTLTKLCALVYGRTEEVVRELGLTFEELRAKALRTLPIPAGRLHRKRLPLLRLMRFAEARKAVLTANAEWEREISDASPVPVLVENDVDLEVAPTSYRFIRDYESSYVDLTARPVLSCTCEDCFAERASCCASHFGGRFAYDARGRLLLPPGHEVYECNRSCACGGACPNRVVQRGPTRPLAVFRTRDGRGWGLRTLAPLERGQFVLEYLGEVITPLDAEVRDAAYDVTGATYLFDLSGGAFTVDAGQKGNASRFINHSCDPNLQVYTVWGDQQDPTLPRLAFFARRRLPRGEELTFDYQMEARLGDEYLQGDRMRCRCGAPSCREFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7C8</accession>
    <name>A0AAV6U7C8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000596">
        <property type="protein sequence ID" value="KAG8179944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7C8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="170" mass="18965" checksum="EC167BA0C188AD62" modified="2024-11-27" version="1">MLISNKGFTNGGFQKQDVIYGASMVSETTLKREKVPFSSKQYKRRALTIRSINLQKQLVRAMGRILTSDETLHAENLSPVTTECPQHLGEKKSTPCFSFSENETSFNIQDSSGDEDLPPLIVEVEENISEMPFPSMGILTSDETLHAENVSPVTTECPQHLGEKKSFLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U878</accession>
    <name>A0AAV6U878_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_020814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000600">
        <property type="protein sequence ID" value="KAG8179831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U878"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="45"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="338"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8179831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="417" mass="48554" checksum="C7A7CC0E0A84C3C9" modified="2024-11-27" version="1">MIKEIGKATTPKNTKKDQQVREFVLKNHVGLEDLPYQIVKQHLAQGFNFNIMCIGETGIGKSTLISSLFDLKFDSLDTKENVHSHRNVMLRSEEYNLQEKGVNLDLTVVETVGYGDQIQREGSYEPIISYIDSQFDKYLEEELNPRRQLALIKDTRIQVCLFFICPTGHKLKSLDLLCLKQLGGKVNVIPIIAKADTLSKDELQAYKSNIRMELEKENIQIYRFPTDDESLVENNSTLNAMIPFAVVGSNDLVVRDGKLVRGRNYPWGIVHVKDENHSDTSSLLKGIIDNNMMDLKEQTHFKHYENYRKELLSAIEQSSGNGMDVWNFRSDEVRKEFQRQEEKLMQDFVEKAKRFEREMVHQEKTMKDKYERMEQNALEEKIKLEEESRQLDLEIELFRMKGKEKKFAKGDVCDTMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8G3</accession>
    <name>A0AAV6U8G3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000559">
        <property type="protein sequence ID" value="KAG8180540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8G3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="136" mass="15236" checksum="09201822031D707F" modified="2024-11-27" version="1">MGEPSLKTHAKGAKHQKLVKNGAKKFDLKSFFPTQNPGGESSSQPIASHSVLPTSVAHLDKCVNVNNLSIKAEILWALKVLNLHYSYKSCEDEIEKKKFTRPTSKSFEILQDIVKDELFSVKCNFLLSICKDIDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8V4</accession>
    <name>A0AAV6U8V4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000551">
        <property type="protein sequence ID" value="KAG8180772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8V4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9848" checksum="4D01189F232F1B4B" modified="2024-11-27" version="1">METSDSILRLDKGDDCWYVFAVSGIRDLFTKHSRSVRFVQFLPCDLRQSGTGVPNSKDGVTCLVPIETRRPPETAIWSIKTMRRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAZ1</accession>
    <name>A0AAV6UAZ1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000511">
        <property type="protein sequence ID" value="KAG8181507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAZ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="143" mass="15665" checksum="FCDFBD132766AE13" modified="2024-11-27" version="1">MTSPVKIGNSSYERKLESTSGSVEKHALTLDQLMTFLMLGSTLPVEPLALQFLTNLKTLDLSRNAIETMCLQVTLYTAMDQLVLPVGSEVRGDGDCASPPDYALSPLRQASRATLTERCTRDGVLGTLVPALRRLRKKPTKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UB51</accession>
    <name>A0AAV6UB51_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAM136A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM136 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000536">
        <property type="protein sequence ID" value="KAG8181088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UB51"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008560">
        <property type="entry name" value="DUF842_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21096">
        <property type="entry name" value="PROTEIN FAM136A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21096:SF0">
        <property type="entry name" value="PROTEIN FAM136A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05811">
        <property type="entry name" value="DUF842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16192" checksum="B355755CB56CF218" modified="2024-11-27" version="1">MAELASAKVKDAITSMLEEIDRSCMRRMQGRMHRCAANCCDNMDLSIDQVNACVETCSKSMGEAQNFVQNELNNYQDRIQRCAQSCQDNLRDKISPSTSETQIAAYKKDFEGCVVNCAETHIQLVPAMLKRVKEFLNRTTDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBP7</accession>
    <name>A0AAV6UBP7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylethanolamine-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000486">
        <property type="protein sequence ID" value="KAG8181962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBP7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21472" checksum="BF17A0FB8F1BF315" modified="2024-11-27" version="1">MSVNDSSENCIVYKSSKVVPDVVSVGPKLTALIRFDGVVVNMGNELTPTMVKDPPTSVHWPMEDQKFYTLCLTDPDAPSRDEPKLREWLHWLVVNVPHNTEIQSGSILAEYIGAAPPQGTGLHRYVFLVYKQQAKLDCDEKVLLGNSAKGRGNFKIEDFAKKYELGNPLAGNFFYARWDSYVENIQKHLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCI7</accession>
    <name>A0AAV6UCI7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000539">
        <property type="protein sequence ID" value="KAG8180991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCI7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="142" mass="16196" checksum="CE757CBB0510989A" modified="2024-11-27" version="1">MNLQEPSREAIDSLSKALRNIPKHVFGNHTECSDKCRRKQRDTCPNVFRLMKESGMLFAIMDEKDASAKDEKLAHLKEKVKKYKQKYRAAKEEVETASYREPESIKEIGPNVRVPEEKLALCRGTDSSTYTGDLMEVVFGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDU8</accession>
    <name>A0AAV6UDU8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000473">
        <property type="protein sequence ID" value="KAG8182260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDU8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="6373" checksum="35569E30036C2354" modified="2024-11-27" version="1">MVDGVVVVVCVRRVVVGDPAGGAGGPRGVSGRGGGPPGLAAPVAPERGVGAEGQTGPDRCRARTPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDZ2</accession>
    <name>A0AAV6UDZ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000458">
        <property type="protein sequence ID" value="KAG8182602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDZ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7967" checksum="92B6D914A688A3F5" modified="2024-11-27" version="1">MVQTEVPQLLQEQIVFVLRRTLFLSFCRLFCLWSCPPFLGFSCFCWLRQKSFNWRKSSSSRELLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF27</accession>
    <name>A0AAV6UF27_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000466">
        <property type="protein sequence ID" value="KAG8182358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF27"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11595" checksum="6025D22785D1BF8D" modified="2024-11-27" version="1">MHQPFPSFHFVSILNIGSYSNFKRAPLRRVGGSMYSIGFCRQFSIRELGRHPFDEKKIRLEKKDVPKELTHTQDGKKKVLEMSKSAFFADLHNTVKRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF29</accession>
    <name>A0AAV6UF29_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000465">
        <property type="protein sequence ID" value="KAG8182364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF29"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9112" checksum="E1FF7BDCE58D0D01" modified="2024-11-27" version="1">MDEKTRGLKDYGFESFHCSKVAKKDLEGLKGFEVAGRPMKKDRAIERTDLGREPSFMDSRDLDRSGIVLEPVENCSSWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFE6</accession>
    <name>A0AAV6UFE6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000430">
        <property type="protein sequence ID" value="KAG8183150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFE6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043798344" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21502" checksum="D466C5061C7F1AB2" modified="2024-11-27" version="1">MWTFIVSCALLYVSSVASEAGPCDVSRYVDCMGPIHNATFGHQHGLFQDANDLAEGCPVIKRGVKCIQDFATECGTDMIAENYHEQFERPAEFLIRICDSQSELRTEYLKASPCLLEANDDLEVCSTKVQEFLGIFEPKTEETELTMTCIYEMMLRACLMSTSVEKCGLETANFVRKALQFSPSLGMETCAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFQ4</accession>
    <name>A0AAV6UFQ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_010738</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000464">
        <property type="protein sequence ID" value="KAG8182375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFQ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001046">
        <property type="entry name" value="Probable ATP-dependent RNA helicase ddx56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="46"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="236"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="507"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8182375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="555" mass="63042" checksum="3E6AAB28CF9D7738" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGB7</accession>
    <name>A0AAV6UGB7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_016978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000428">
        <property type="protein sequence ID" value="KAG8183190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGB7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033290">
        <property type="entry name" value="CCDC39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18962">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18962:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24161">
        <property type="entry name" value="CCDC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="75"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="327"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="622"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8183190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="801" mass="93577" checksum="369DAC1F5051FA9A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHW6</accession>
    <name>A0AAV6UHW6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_008285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000419">
        <property type="protein sequence ID" value="KAG8183383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF14">
        <property type="entry name" value="OS05G0225800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043697797" evidence="3">
        <location>
            <begin position="20"/>
            <end position="2987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="690"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="832"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1448"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1602"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1768"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1860"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2018"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2096"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2184"/>
            <end position="2218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2248"/>
            <end position="2288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2322"/>
            <end position="2356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2524"/>
            <end position="2558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2754"/>
            <end position="2864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8183383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2987" mass="283121" checksum="50E042DA8029C301" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJH1</accession>
    <name>A0AAV6UJH1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000399">
        <property type="protein sequence ID" value="KAG8183893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJH1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="36"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="187" mass="21342" checksum="CC0C829F1AFE00F5" modified="2024-11-27" version="1">MIPANVTIHCRDFAFQNRNLSTFQIRNRFNSFRNQNRGSVFLATDASKSLFRVTVAAININNNQRISGELDYYYSINSAEAVAIILALQNYVVANVNYVLLTDSMTILRGLKRNSSLSVIRRLNEVINHVSSLSVSLKLVWVPSHKGIPENCLADKLAKYARARTIVHWIPLEDIQREEEKYDLESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAV6UKH9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000391">
        <property type="protein sequence ID" value="KAG8184010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKH9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="9135" checksum="66CFACB9949BDED9" modified="2024-11-27" version="1">MFGGDRYHNKGRLPSKAADILLSDHKSPDGHYPVKTLGSSRGMEEGLVDLSTAHTLTSDNRKPCYHCLKMSDSTEMSHMLTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMF3</accession>
    <name>A0AAV6UMF3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_019737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000334">
        <property type="protein sequence ID" value="KAG8185479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMF3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043787084" evidence="2">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8185479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="133" mass="14945" checksum="C4EAD6540E2815BC" modified="2024-11-27" version="1">MYLSTCIGMIYFLCFTVECGRMIRRQPNAFVEIIDINNSTMEDSVQYNLTIEASTTDSTVLQEDLLTSIPMNETKVVGIVHPKYRMMPLAVGGITLLAGLMSITIVVGLFIYCNRRNDIVYEPATSVDIEQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMG6</accession>
    <name>A0AAV6UMG6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_022359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000335">
        <property type="protein sequence ID" value="KAG8185427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMG6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8185427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="52013" checksum="E4E37907580CA9BA" modified="2024-11-27" version="1">MSSNEAVTSYLPLEKELHICCKKALHARKNAGCEEDENEPSWICVVVDILISLLSRNSNPLRSVVTSVFPMFCPFINEDALKQILDVINPEKAEDDAMLVDESGGESDAEFDSGSSSSEEESDSIEQKNSKVDEVFRRKVKEALGAAAEVSDAESIVLSDSEMFKMDDALAEAFKSRVQTGHTQLKDKDKVMLNFRVRCLDLIMEFLKSDPPMHLVMLCIQPVLAAYEYGHKGRLQNHLLSKAISTLQLLTRIKKFQNQDNVDKSQIKELLKSLMAKCHKERNLVVAKKLYSVCVFLVLCFRRIETSESPSKKTKKSSYLKIYLSALEAFVRGSSSHAYPQLFVSLMEACPELAWSFIQPCQQYAFDDSVRIYKKTQCFGLIFEALKYSKGQTAISAKDWLEVGNNFMSQAVETLKSISEVKPAKSAELLNVVFSFYCIVKDKTGQDYGPVAELLECGCSMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPL5</accession>
    <name>A0AAV6UPL5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Malvolio</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_025892</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000343">
        <property type="protein sequence ID" value="KAG8185221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPL5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF33">
        <property type="entry name" value="NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8185221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42073" checksum="2CE04FC90F955164" modified="2024-11-27" version="1">MLEITIIAADMQEVIGTAVALYLLSNKYIPLYAGVLLTIVDTFTFLLIDKYGLRKLEAFFAFLIAVMAITFGYEYGSVSPDQAELQKGLWVPGCGPCSNRVLLQAVGIVGALITPHNLYLHSSLVKSRAINRANKDEVRDANRYYFLESAIALLVSLVINIFVVAVFAKGMYNKTNNDVLSLCTDRGINATDIFPENDEQIQGDIYRAGIFLGCQFGQAYMYIWAVGLLAAGQSSTMTGTYTGQFVMEGFLKMKLSRWKRVLVTRTLAILPTVAVALLQDVNHVSGMNDILNALMTLQLPYALLITFAFTASRTLMGEFANDKKTNVFMGAFTIAMIGLNLYFIGNFVVENFPNTWWVYTLFGIFLVLYMAIILFLMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPM0</accession>
    <name>A0AAV6UPM0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000302">
        <property type="protein sequence ID" value="KAG8186405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPM0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12323" checksum="7289126274881AEC" modified="2024-11-27" version="1">MPSPVMVKRASVVSARIQPDSGQARKESNGRINGPLMDRGVAVFINVDKEPRVAPSVIVEARMCSKPFGRKKSDDRNIKCRSHRQIDKCSCLALEKTTDYCSQKWMMGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPY7</accession>
    <name>A0AAV6UPY7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein CLP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_005879</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000305">
        <property type="protein sequence ID" value="KAG8186351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPY7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="4">
        <location>
            <begin position="116"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8186351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="46227" checksum="4776CBFE4886831B" modified="2024-11-27" version="1">MAELFQESQVFNLENENELRILVGEQPTTIQLTSGLAEIFGTQMIVNDEYRLPSHSSIAIFSWQGCSIKITGKPVSAHVVSDTLMILNVILHASLEELRIKAKAENSKGPVVLVVGPKDTGKTSLCSILLNYATRMGHRPVYLDLDVGQNSITIPGSVGLVDVKKPASIVRGFSDRPAMLYHFGYNSPGHNLALYYLLLRQLQAVVQSHFQHASENVRSSGMVINTCGWVIEDGYNTIVFAAKAFQIDHLCVLDDEELHSKLSNDMPPNVKVHYIPKMTGVAQRSPSVRFKMRNLSIFNYIYRNQEKVTPKAFVVLYSRINVIKLSFQRPLNGPDIEIGTRDLIVATQVPLTQELTNKVLGMSLGQTIDDKMLMRVIGFALVKHVNVDKGEIKIVTTQPDPQLTKFFLVGNVKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ52</accession>
    <name>A0AAV6UQ52_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000307">
        <property type="protein sequence ID" value="KAG8186289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ52"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8366" checksum="63158FD7A44DABE0" modified="2024-11-27" version="1">MDVLSESHIRFGPATATQDHGLMKLPVLLELLHAEFQEVVVFVVRLAFQVIEMQGLELFHGNAGMVCVCVEDRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQE1</accession>
    <name>A0AAV6UQE1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Actin-like protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_010721</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000320">
        <property type="protein sequence ID" value="KAG8185938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQE1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031252">
        <property type="term" value="C:cell leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000803">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8185938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="418" mass="47292" checksum="13802C9AFECA7C12" modified="2024-11-27" version="1">MAGRLPAIVIDNGTGYTKLGFAGNREPQFIIPSAIAIRETAKIGDQAIRRLGRGIDDLDFYIGDEAIDSTGYSVKYPIRHGIVEDWDLMERFWEQCIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQMGERTLNGLVIDSGDGVTHCIPVAEGYVIGSCIKHIPIAGRNITYFIQNLLREREVGIPPEQSLETAKMIKERYSYICPDIAKEFSKYDQEPSKWMKKYEGINAITQQPFSVDVGYERFLGPEIFFHPEFANPDFMVPISEIVDTCIQSCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDIKRVVDARLNLSASLSGGRIKPKPIDVQVISHHMQRYAVWFGGSLLGSTPEFYQVCPTKAAYEEYGPSICRHNPVFGAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQE6</accession>
    <name>A0AAV6UQE6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000317">
        <property type="protein sequence ID" value="KAG8186003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQE6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="8137" checksum="114CFBE7F3104296" modified="2024-11-27" version="1">MTHFNPELKQGHEIFTLSQFHPHLKRPTSTGFPLQRLNKPKVWTTPRGALERCPLRHLGKPFMDLPYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQL5</accession>
    <name>A0AAV6UQL5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAM234A/B beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_004435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FAM234 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000316">
        <property type="protein sequence ID" value="KAG8186013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQL5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055409">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045232">
        <property type="entry name" value="FAM234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419:SF30">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23727">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="FAM234A/B beta-propeller" evidence="8">
        <location>
            <begin position="145"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8186013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="582" mass="65207" checksum="1B0CBE1B483ADB16" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQR9</accession>
    <name>A0AAV6UQR9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_020495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000288">
        <property type="protein sequence ID" value="KAG8186817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQR9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF103">
        <property type="entry name" value="ROUNDABOUT HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="130"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="201"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8186817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="367" mass="40697" checksum="5CB0602835B36591" modified="2024-11-27" version="1">MLRKSIRNKTVREESLEEDPQPPTDAPDFTTSTIHNCTVDETARTVNCHSSGPESSMCCTVTVRNFSNFRPPCTPIPEESRQSSQNSGNVHSTQSSCILSIPASQSISNSSSNSRRKRHLATYHLTTCLGSSVRVTCETDQSCSDRQVSWRKREVQRSTQGRDLRIKVVGSGDDGEYVCEITDYFGKTRVAAVVVINTQFPPTISLPSPRSQDYPLECVSVANPSPVVRWLKDGAPLPPDPRFVVSMETSDCTTRSRLRLLTTTLVVEGNVTTVREEEVEGNFTCLATNVHGLASAMVILPVVPKESEPLSPILSIRRFNVTGFIVGMLPPLFISFYIILKLGYRSRYAQEGGEDDGFRDEPFFISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USF3</accession>
    <name>A0AAV6USF3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000294">
        <property type="protein sequence ID" value="KAG8186684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USF3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043899527" description="Secreted protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14517" checksum="DD064254D1E96FA8" modified="2024-11-27" version="1">MAFEVNPIEAAFAVLLFFLFLFLLATWCCRQCSRTKDVRVNLVPHPVQPRYVETVDVQTGLPVVVDIESLGNLPRNHGTVSQQQRRMSYPVSVRRQSMYGAMDQQIFPRTPPPAYSEVVEIHTPNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USL1</accession>
    <name>A0AAV6USL1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="12">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_020491</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="12"/>
    <dbReference type="EMBL" id="JAFNEN010000288">
        <property type="protein sequence ID" value="KAG8186813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USL1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007871">
        <property type="entry name" value="Methyltransferase_TRM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039044">
        <property type="entry name" value="Trm13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021721">
        <property type="entry name" value="Znf_CCCH-type_TRM13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998:SF0">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05206">
        <property type="entry name" value="TRM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11722">
        <property type="entry name" value="zf-TRM13_CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="13">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8186813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="423" mass="48887" checksum="64D1FE200B081463" modified="2024-11-27" version="1">MNKRPAEDQNVCSFFLERKKRHCRMKTNEGMTFCPHHSHLGVDEDPKKGLRVPCPYDSSHFCYEAKLQKHLKKCNAREKDKPKYHVESVNVEVNHSESLKLCLRDVPDDELIEFVNKIKSLYDKHGEEIVEIQAMHPVLRTEMEKSDDGFNAFKHMKQQASLLSVMEDNNFLKDGSCFIEFGAGKGQLMYWIISCIPKNEERNFILVDRSAQRHKIDNKFKDTDLQIERIRIDIQHLHLGHIESIQNKLDKVVGVSKHLCGAATDLAIKCLMDTLVTEEKVSHNALGLLMALCCHHRCSWNSYVGRNFLEECGITEREFQIMCCIASWATCGLRKTKTPAEKPEVPNPYFPENAQDENLLNRYKKLNLKHEEREIIGMQCKRLIDAGRVLYLRKKGYDTKLVTYIDKSVSLENVAMIAIYKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWT6</accession>
    <name>A0AAV6UWT6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="22">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">JTE90_009192</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 22">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 22">Membrane</location>
            <topology evidence="2 22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 22">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="22"/>
    <dbReference type="EMBL" id="JAFNEN010000230">
        <property type="protein sequence ID" value="KAG8188800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWT6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000021">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 21 22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 20 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 22" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="845"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="872"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="913"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="955"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1027"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="23">
        <location>
            <begin position="128"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="25">
        <location>
            <begin position="806"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="19">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="583"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="663"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="665"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="753"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="759"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="779"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="782"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="783"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="783"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAG8188800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1145" mass="129484" checksum="112B0CB28D91D228" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UX73</accession>
    <name>A0AAV6UX73_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000245">
        <property type="protein sequence ID" value="KAG8188244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UX73"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="161" mass="18054" checksum="4C9F8EDA71443634" modified="2024-11-27" version="1">MDALTTRKPYLKGQVTRLTNNVQALGDTTVQIVRLKHYREQATTLVGSVTTLYEELLALVEKTDYETTEQEFHGELNRLDELIISIDGLLTLNAAQPTSSDNHANGSGAAILYQWWMQDLRATAQHSTTHPQRGSRAVIGEFVTRTTCRKPASFVHSPCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXT4</accession>
    <name>A0AAV6UXT4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000220">
        <property type="protein sequence ID" value="KAG8189160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXT4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="1">
        <location>
            <begin position="46"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="209" mass="24249" checksum="8D38AEA7BDF76342" modified="2024-11-27" version="1">MDKSLAKPPTKRRRRTKPKPLVYINSQSNKRKLNPNKFNHTRDGTFRIYPMRADGNCLFRAMAYYVLGNQKENGFVRHLIAGHISRNFSKYIDFIGEERAIYLQRMYQAGEYGGHIEILAFTEIFGCAVNIYHQDHPDDSPLRVGSASEALPLIYSGITDSGHYNVLLPLSTSNLDVESHKDYIRRLRESSCRRFDNNMKNFKVLEKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXV0</accession>
    <name>A0AAV6UXV0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000241">
        <property type="protein sequence ID" value="KAG8188330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXV0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8910" checksum="17845D87FCEC3EB5" modified="2024-11-27" version="1">MVSTVYLLFAEGCSHFAKREFLLLPEMVSTVYLLFAEGCSLFTKRELPLLRRWLVRSIFFSQRDVPSLRRGITPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V030</accession>
    <name>A0AAV6V030_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000200">
        <property type="protein sequence ID" value="KAG8189899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V030"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="9846" checksum="16BBDE5D678C6A5A" modified="2024-11-27" version="1">MDPPTGKGAYAPNSSSPPPISDVTSHSYANARKTPVTAVYQPMAVKHSDPDVSSSVSLHAIETHMEDHGRASHHPTVPLSQKDPLLQEIELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1R0</accession>
    <name>A0AAV6V1R0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_009101</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000199">
        <property type="protein sequence ID" value="KAG8189962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1R0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.180:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="8">
        <location>
            <begin position="217"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8189962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="596" mass="67254" checksum="DE30F79D966A03B9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V434</accession>
    <name>A0AAV6V434_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_017889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000179">
        <property type="protein sequence ID" value="KAG8190625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056939">
        <property type="entry name" value="Znf_RING_Vps8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23412">
        <property type="entry name" value="zf_RING_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="1249"/>
            <end position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8190625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1399" mass="159319" checksum="6433375783E440BD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4V5</accession>
    <name>A0AAV6V4V5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_019576</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000158">
        <property type="protein sequence ID" value="KAG8191512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="8">
        <location>
            <begin position="1816"/>
            <end position="1971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8191512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2105" mass="239386" checksum="D6A1A726F3C3847B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V893</accession>
    <name>A0AAV6V893_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADAM10 endopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_022809</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endopeptidase of broad specificity.</text>
            <dbReference type="EC" id="3.4.24.81"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.81" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000151">
        <property type="protein sequence ID" value="KAG8191816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V893"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049038">
        <property type="entry name" value="ADAM10_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF2">
        <property type="entry name" value="KUZBANIAN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21299">
        <property type="entry name" value="ADAM10_Cys-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043664044" description="ADAM10 endopeptidase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="738"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="10">
        <location>
            <begin position="254"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="9">
        <location>
            <begin position="511"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="764"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="795"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="828"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8191816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="873" mass="98800" checksum="79E99D6329427DA4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9K1</accession>
    <name>A0AAV6V9K1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3CxxC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_003781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000125">
        <property type="protein sequence ID" value="KAG8193294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9K1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13695">
        <property type="entry name" value="Zn_ribbon_3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="4">
        <location>
            <begin position="43"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8193294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="163" mass="19119" checksum="5CBCC560AE53094D" modified="2024-11-27" version="1">MANPPARIVDPANLQALFYKIMERYQVKANEIKNLKVALVDVHGHGLFDCFKCYHSWYSHYSWVQLDLKEMKVNYRWKMKCQKCYRGHPAAAVGIKPTFGVEEMEKMIENAVCRYKGVEFPKKNPGNRRRHEFVPPHFSELCEKCGWGQVQCWTLPPYSSFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9N9</accession>
    <name>A0AAV6V9N9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000122">
        <property type="protein sequence ID" value="KAG8193435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9N9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="14367" checksum="BC47D110C30307CC" modified="2024-11-27" version="1">MDRYIMIDMIHINLNFPINILKHHGTYMRNNTNLKRSQQAHTSSQQRNLLQVNHLHQSSLKRLLTASINVVNLQTIRSTIHHLATPPDFDRPSKTNRSVDSGQTIYSGSPLREIGIYHVFRGGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAV8</accession>
    <name>A0AAV6VAV8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_029544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000114">
        <property type="protein sequence ID" value="KAG8193810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAV8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057749">
        <property type="entry name" value="WDR47_COR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25602">
        <property type="entry name" value="WDR47_COR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="3">
        <location>
            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="723"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="817"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="865"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="907"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="953"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8193810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="989" mass="109534" checksum="6101AE21D889DE85" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VB00</accession>
    <name>A0AAV6VB00_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_014632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000134">
        <property type="protein sequence ID" value="KAG8192856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VB00"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8192856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="708" mass="80900" checksum="27815AEEF6256875" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VB64</accession>
    <name>A0AAV6VB64_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000118">
        <property type="protein sequence ID" value="KAG8193596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VB64"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9658" checksum="7A54020FA3F8C258" modified="2024-11-27" version="1">MTLTSHQIFRPSIKPALTKQPAQCPISISQINQSRRGIPSLIKHVTYQRGVHHERSLHTTGRSKMSVGSASPWLLSLVALLTHFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCI0</accession>
    <name>A0AAV6VCI0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000106">
        <property type="protein sequence ID" value="KAG8194227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCI0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="206" mass="24410" checksum="C68BE19EDA094234" modified="2024-11-27" version="1">MCFETSYSYPSKITNFEFKHEETFALSDADGQDYDYDAAADDADLPHVRKRRSAQWAPDYDLYSRWAEEYYEDESLDKSAGAAEKPKEDLLDRLMSRNRTEEELQSEREWHMKKKDRIMKAVLYGCWALGVLILTCVFRVYLKRLLGICGCDFCDVFRFRRKMRRVVGNFTPGVYVHENGEKEYYPPTEEEIKALKDMRKLLFSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDK2</accession>
    <name>A0AAV6VDK2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Solute carrier family 13 member 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_017221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000098">
        <property type="protein sequence ID" value="KAG8194779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDK2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="KAG8194779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="57400" checksum="8D376489DD6E650F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFJ7</accession>
    <name>A0AAV6VFJ7_9ARAC</name>
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            <fullName evidence="8">Phosphodiesterase</fullName>
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        </recommendedName>
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        <name type="scientific">Oedothorax gibbosus</name>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
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        <text evidence="4">Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Vital for female fertility. Required for learning/memory.</text>
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        <cofactor evidence="8">
            <name>a divalent metal cation</name>
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        <text evidence="8">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <keyword evidence="1 7 8" id="KW-0479">Metal-binding</keyword>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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        </location>
    </feature>
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        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="320"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
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        <ligand>
            <name>AMP</name>
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        <ligand>
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            <label>2</label>
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    </feature>
    <feature type="binding site" evidence="7">
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        </location>
        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
        </ligand>
    </feature>
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        <location>
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        <ligand>
            <name>AMP</name>
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        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
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        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8194807.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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        </source>
    </evidence>
    <sequence length="610" mass="68078" checksum="25A6BDA955927E90" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGY2</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000091">
        <property type="protein sequence ID" value="KAG8195182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGY2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9395" checksum="3EDBA73177F354A3" modified="2024-11-27" version="1">MGVVIAVVGMFLAADRKSKNSSIYSIASAIITGRVTVAFSGFFLKIVLLIKSWWGLIDKGWRGSAFFFYSSCGVFIHAEGVLPSRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VK18</accession>
    <name>A0AAV6VK18_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4 18">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">JTE90_029007</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 18"/>
    <dbReference type="EMBL" id="JAFNEN010000075">
        <property type="protein sequence ID" value="KAG8196038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VK18"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="23">
        <location>
            <begin position="100"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="397"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="19">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAG8196038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="559" mass="64852" checksum="73B129708CDD7053" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM30</accession>
    <name>A0AAV6VM30_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 8">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_007281</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="JAFNEN010000054">
        <property type="protein sequence ID" value="KAG8197545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM30"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000114">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="330"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="128"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="274"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8197545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="476" mass="53089" checksum="09E4FE9114A21644" modified="2024-11-27" version="1">MVKKICCIGAGYVGGPTCSVIALKCPDITVTVVDKSEMRINAWNSNQLPVYEPGLDEVVKECRGRNLFFTTEIDTAIREADLIFISVNTPTKNFGFGKGRAADLRYIESAGRRIAEVAQTSKIVVEKSTVPVRAAESINSILRANTKPGVTFQVLSNPEFLAEGSAINDLLHPDRILIGGDQTQEGKNAIQKLCSVYKRWIPENKILTMNTWSSELTKLAANAFLAQRISAINSISAICEATGADVSEVAHGIGTDTRIGPKFLTASVGFGGSCFQKDVLNIVYLSECLNLPAVAAFWYQVIEMNNFQRTRFARRITENMFNTVTGKNIAIFGFAFKKNTGDTRESPAIYVCKHLLEEGANLHIYDPKVERKQIILDLECTDGIEDSYKVEDQVLNFPCPYQAAQNTHAIVICTEWDEFLELDYKKIYDNMFKPAFVFDGRKMLPTERLQNIGFHVETIGVKTNRKQNRNIADYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP03</accession>
    <name>A0AAV6VP03_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_014930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000055">
        <property type="protein sequence ID" value="KAG8197448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP03"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000032">
        <property type="entry name" value="Nucleolar MIF4G domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="574"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8197448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="778" mass="90138" checksum="2459A30E6420618A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPH5</accession>
    <name>A0AAV6VPH5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPH5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="102" mass="11721" checksum="288DAF6E03B0FC88" modified="2024-11-27" version="1">MPCGCTIIGERDAQDPLILSSATGDRRTRHLKSQRTHIFQGKKHDASKQNVVGSRSLLCSCQHDVPHWDSYNTFQLNCQHPTRGKYRDLHRNHSRANNRDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQ87</accession>
    <name>A0AAV6VQ87_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Insulin receptor substrate 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein chico</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_001606</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Bindings to phosphatidylinositol 3-kinase and SHP2.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQ87"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005158">
        <property type="term" value="F:insulin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01257">
        <property type="entry name" value="PH_IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01204">
        <property type="entry name" value="PTB_IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039011">
        <property type="entry name" value="IRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10614">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10614:SF13">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00628">
        <property type="entry name" value="INSULINRSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="7" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="IRS-type PTB" evidence="12">
        <location>
            <begin position="138"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="638"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="725"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="879"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="933"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="546"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="653"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="763"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="806"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="966"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="998"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8197681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1008" mass="109670" checksum="7A2502C8C3FD1CE5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQH4</accession>
    <name>A0AAV6VQH4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_029395</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000046">
        <property type="protein sequence ID" value="KAG8198001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="8">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="9">
        <location>
            <begin position="385"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="11">
        <location>
            <begin position="708"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="10">
        <location>
            <begin position="916"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="12">
        <location>
            <begin position="1087"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1159"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1257"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1159"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1174"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8198001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1315" mass="148892" checksum="D62FE9382AC86C08" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSZ2</accession>
    <name>A0AAV6VSZ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Reelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_000867</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment. Regulates microtubule function in neurons and neuronal migration. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Oligomer of disulfide-linked homodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the reelin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070325">
        <property type="term" value="F:lipoprotein particle receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034968">
        <property type="entry name" value="Reelin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049419">
        <property type="entry name" value="Reelin_subrepeat-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11841">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="10"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043686607" description="Reelin" evidence="17">
        <location>
            <begin position="29"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="18">
        <location>
            <begin position="27"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023773"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8199774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1886" mass="208448" checksum="AC9DA159CD5AEEE8" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT04</accession>
    <name>A0AAV6VT04_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mesoderm induction early response protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_016029</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000030">
        <property type="protein sequence ID" value="KAG8199208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT04"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transcription corepressor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045787">
        <property type="entry name" value="MIER1/3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF28">
        <property type="entry name" value="ELM2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19426">
        <property type="entry name" value="MIER1_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ELM2" evidence="11">
        <location>
            <begin position="176"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="297"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8199208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="62190" checksum="C6AE27642C2B263C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTI2</accession>
    <name>A0AAV6VTI2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_021902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000017">
        <property type="protein sequence ID" value="KAG8200247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTI2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002060">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8200247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="230" mass="26092" checksum="F855995380E6DE55" modified="2024-11-27" version="1">MVFKSLSIRSTTDFVCRPKMVRSRNLKLTVVGDKGVGKTSLLKTYAKGSFPGGEYVSTVFPFLPDEEYVYSRSIDYSGQPVLLAMWDRVYFNQKEDDDIRAVQFYQTDVFLLCFSVIDQRSFSNILQIWKPEILKHCPKSKCLLVGLKKDLRCAKNKSDPSQSVITRSMGRDMAERIGAVDYMECSAKTKDGIKQVYAVAIQSAMGNPPHKQKKLVKCGGCRLYRLARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVC4</accession>
    <name>A0AAV6VVC4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVC4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="189" mass="20483" checksum="823A377B1DA98E59" modified="2024-11-27" version="1">MSLRSLCCVGGRRAAISGVETRLSNAAANDPEHTNLTLIVCFYPPCVRILNFIKLYNCFDPLLADDAGGARMLTGGHRRVAVCSRAGGRRQYCVPRPVPPHLQTGATTGIPGDGLLAHREAQRLPHAQQRPPHQQQAEEGAVLVVPAADRGPLHHARDGQLVARGMPHLLRLQDAPRTHMLLQGQEALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVZ1</accession>
    <name>A0AAV6VVZ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_022356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVZ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043327925" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="640"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="77"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8200755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="760" mass="85314" checksum="DFF88ECAB8B611A1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VW23</accession>
    <name>A0AAV6VW23_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Clarin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_021433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the clarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000010">
        <property type="protein sequence ID" value="KAG8200969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VW23"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026748">
        <property type="entry name" value="Clarin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548">
        <property type="entry name" value="CLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548:SF1">
        <property type="entry name" value="LD47387P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25807">
        <property type="entry name" value="Clarin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8200969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29173" checksum="4A882DE9032BDCB0" modified="2024-11-27" version="1">MRTDLTKRVLTFCTFFVCCGCLALLSAAFATQKWIVAKPVKIGLPESISNATAGDDTKFRGELYFGLFEGSKTLNYGFGDRKTQIWIQQEMTKNPQLFTFSLWLLTIMSLALAMLFGLISAVFAVINTVVTPVEVITGISGLYLWNGIGALFSAGSVISWAALYYTKLQHNVMTKEELDQQWISKDKAWFGYSFWFAVVTFVLFSANIILTSLAVRQPWEKRKPKLSVNKNPEESEIFLNTILFLSSILKKNKVFQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWS3</accession>
    <name>A0AAV6VWS3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000018">
        <property type="protein sequence ID" value="KAG8200221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWS3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="290" mass="33282" checksum="C0E7D6736FB75F09" modified="2024-11-27" version="1">MPTLRSSSAQREISLRKQLLNKIFLQTLNHDPLPEPPLLGAHPLKLPSSIREQPANFEIAEQGDVEMKKEVSLTDGECIYAAPTEKQSMYPQSEISYEQCQAFDLASNIIDSQDSSLSMVATSPIKTTYSETNVTIVQHTPMSSKKLSKKSSKILARIEYLERSVGVFCEKENETPHDVFDFPNQDISIFQNIKTSQQRKKYEKFFKKALKVCNRLEGEISLYSQYVDTLETAVSSIKKGSKLYKMLEAKLRTAYKFQDENPSHEQLKTLLRQLKLVNLLLNKYEYERLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXH8</accession>
    <name>A0AAV6VXH8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000006">
        <property type="protein sequence ID" value="KAG8201334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXH8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501:SF5">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501">
        <property type="entry name" value="TRANSPOSASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="676" mass="77011" checksum="9CE0F2C551F99DDA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VY31</accession>
    <name>A0AAV6VY31_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000009">
        <property type="protein sequence ID" value="KAG8201021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VY31"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10298" checksum="5C1CDEE0AD696B34" modified="2024-11-27" version="1">MRRNFETQRTLTQTSTLHKQPPNPFADKTGLTLLSLMLSILPRSEDADQSTCGIITIPTVPPDWSRILLKESAAQNILGSCCFQKLPPPCAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYR1</accession>
    <name>A0AAV6VYR1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_015764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000012">
        <property type="protein sequence ID" value="KAG8200859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYR1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="3">
        <location>
            <begin position="76"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8200859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="166" mass="18192" checksum="328198F83E977D6C" modified="2024-11-27" version="1">MHRPDKLAAKLKPSCRSSAKSLSSSSPVAADLKERSSRSLLANVLDLDDDFRPPRAGSSYGNNCSRQSGYVQLLGQSVEGTPTTANPATAAPVTSCLSYQREISDILSEIKFITKRMRDDDATKEIISEWKYMGMVVDRMCFILFTAFTIISSCVCLLSAPHLTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W2K6</accession>
    <name>A0AAV6W2K6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein O-GlcNAcase</fullName>
            <ecNumber evidence="6">3.2.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_010441</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = N-acetyl-D-glucosamine + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:48876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="3.2.1.169"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:48892"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="3.2.1.169"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.169" evidence="6"/>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W2K6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102571">
        <property type="term" value="F:[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000009">
        <property type="entry name" value="O-GlcNAcase BT_4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.240">
        <property type="entry name" value="STAT, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051822">
        <property type="entry name" value="Glycosyl_Hydrolase_84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="O-GlcNAcase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170">
        <property type="entry name" value="O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170:SF16">
        <property type="entry name" value="PROTEIN O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52009">
        <property type="entry name" value="GH84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH84" evidence="8">
        <location>
            <begin position="20"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8202078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="880" mass="99723" checksum="E09A5D865800349C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEN2</accession>
    <name>A0AAV6TEN2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006163">
        <property type="protein sequence ID" value="KAG8156228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEN2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8156228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="82" mass="9207" checksum="47CEAB8A317056A8" modified="2024-11-27" version="1">MGKRRGVGKRGRDQINGEVLTLLEIPRSWRKIAIPKSPARKRFKGVTLPVGKGERHMFPFNVARWGPDTKGFPPAIARLVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TG58</accession>
    <name>A0AAV6TG58_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004857">
        <property type="protein sequence ID" value="KAG8170805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TG58"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="11163" checksum="422A26CB60327101" modified="2024-11-27" version="1" fragment="single">PKTLPRVGGLQAGFTPGPSTQGHRDPPTHGRRKPPRGEALPKGAPGVIGPTWSAHPFFRGLVASVGELLKTLLSKFRLPGHRPDCLEQPPPFRGVSWGVSHGTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGU2</accession>
    <name>A0AAV6TGU2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005005">
        <property type="protein sequence ID" value="KAG8170705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGU2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025:SF22">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025">
        <property type="entry name" value="SI:CH211-196P9.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="431" mass="48827" checksum="49428799D67345A5" modified="2024-11-27" version="1" fragment="single">PVQKQAIGSTFPSGSTNIAPPSRLPPDWVQDYKIPFDKLPQRLLRVLKEKERADPGSRRQYITIISKEIFTFCPRPGKANLKVVAQKSVQAFPIALVDEFCGEKLAGGYGSLLQSFISKFENLNRQSIFSSVKRKVNTSLDIDDPTKLVKKSDQYGCINWQPEMLPEGETEETQQNKREQLVHLSSLVSRDSVGEEAILLLEDTYCSQRKDINSLTGVKTLLMSWPLLFAEEGLLLHFKLLVGLDISSTFKTSFLRKGVVMEKYFLQNLKGKMKETIVRHPSGSTEVVLLLLMDHFQEKHDSLFIEVDSSSTVKDVESLNILPATPCLVICDNEHSHKSYMVAVDKKVVNETTPTFERAFYMLFASFFVFNIEYTETACSTLEFVQRCFLNINPDKGTKRGSKNPKKKTKTSIMDPKVLTLTQKLGAFEWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIS5</accession>
    <name>A0AAV6TIS5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003819">
        <property type="protein sequence ID" value="KAG8171568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIS5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33267" checksum="9FE924C6ABD640F9" modified="2024-11-27" version="1">MLPFVKVDFEGKSFSLLIDTGSSICLLSYDIFLDIKQSQKPKYLSRSVRIQTVNGSGVRFVSCVELTLKLGGQKLKQVFYVSKDIRGNNLSGIIGCDFIRDNNVSIHLQEQFISLSGLKIPFLGCTERVNTVVVTELPASLVNKQIIGPGETRVLKLRIRQHFVDGTDVLFTPNSKNVHLEIHVAVHKVFCSEFYVIVVNLGCKHMHLNKGMCLGTVTPEFSIRDSERETCSVNLIRASNEVKEMRRRELKATDFELGHLTKEQKNRVLTVLLEHSEVFSKSLKTLGHTDHIVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJA7</accession>
    <name>A0AAV6TJA7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003282">
        <property type="protein sequence ID" value="KAG8172005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJA7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17360" checksum="5F698264073177A2" modified="2024-11-27" version="1">MTFLERYHNVGDDFLSPVVTGAETWVAYVTPESKQQSMEWRHSDSPKRVKFKQTISARKIMCTVFWDRKGVLLVDFLPRNETINAAAYCETLNNLRRSIQNKRRGKLSKGIVLLHDNARPHVANRTKDLITSFKWETLDHLPYSPDLGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKM2</accession>
    <name>A0AAV6TKM2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003019">
        <property type="protein sequence ID" value="KAG8172173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKM2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11957" checksum="2435806442161748" modified="2024-11-27" version="1" fragment="single">LFTVYSNVGEEQMGDGVWRQRHLRLQRDGRRARLATVTFPCGSSMDGKWHRIALSIKGDSVTLISECGRQMTESLGRSEDAHVDLTGIIVVGSQLVDSVYFEVQHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLJ0</accession>
    <name>A0AAV6TLJ0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002699">
        <property type="protein sequence ID" value="KAG8172439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLJ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="102" mass="11317" checksum="7F96EAFC38890C2C" modified="2024-11-27" version="1">MERTTVQNVTEHLENSLAMVCLSSASGLGNPVATSKGMKGVKKKTSPIPSRENRWSLLVKLKDGTWLFPIVDDLRNCLQPAGVIQKRTTHARYYLAAYDTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPZ8</accession>
    <name>A0AAV6TPZ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_013152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001509">
        <property type="protein sequence ID" value="KAG8173758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPZ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8173758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="541" mass="59476" checksum="F7786BEEA23C6C2C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQ74</accession>
    <name>A0AAV6TQ74_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001485">
        <property type="protein sequence ID" value="KAG8173793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQ74"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="146" mass="15904" checksum="3D94884CE253C22E" modified="2024-11-27" version="1" fragment="single">EQKPSGGPCAKNVTSPSGGIHLNFNNFTGECVLPIKPVLKNGTVPTISLFLHSLFLHENDTVTLFNKESDVANDSLSIIEPLGAQNGSVTIVTVEKELYMKFTGNPNVSYVRRFDGMYQGHICAFTISSTPDFDVQLYTLPLPPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQA9</accession>
    <name>A0AAV6TQA9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001491">
        <property type="protein sequence ID" value="KAG8173786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQA9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="159" mass="18592" checksum="9160F1C187C2B544" modified="2024-11-27" version="1">MLDIELSKAVAVSSLNIMEKDHLPGGEEEKLIRRQIFEEDKEEVDEENCGKVFNSLVTTRWCKESVRNEIIVSTKEFLTQRVSDDYQIIKNIKKFLHSKSAKDMIECSRDIVKIYLETVSVEEFRNDVIDRVVHFGEEFVIRSNHCCSVFNIHHYVCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQI5</accession>
    <name>A0AAV6TQI5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001535">
        <property type="protein sequence ID" value="KAG8173701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQI5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="74"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="258" mass="29410" checksum="781DD04FA9167FBA" modified="2024-11-27" version="1">MDTIALLSLWKSHDVSTVGKVRRCCLPKRHIGQIMKKIQLFVLVITSALCSAFSIENDSTDLDNKVERSSQVTNECFPKPVDCEEILMNGNRINGVYTIWPRHRKMSGKSVEVYCDMVTDGGGWTVLQRRGNFGKAMNYFNKTWEFYKNGFGQLEKDFWIGNNLIFTLTNQGSYSVRFDMRHHNGTSAYALYDKFWIEDEDKKYQLNIDGYSGNAGDSMSYHKAMKFSTSDNDNDPYSGNCAVMYSGACGIKVVTKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTC3</accession>
    <name>A0AAV6TTC3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_020628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001118">
        <property type="protein sequence ID" value="KAG8174898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTC3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8174898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="376" mass="43045" checksum="ABD24BEAC13ECCE2" modified="2024-11-27" version="1">MVRDLGWVAIMISVVVLGVVVLVGLLFRFLVMDVVRSREDSGRDERKVDVKRVVVTTALQLSTSILTSLMDLVAKGVLHRDPRDMAVRHELDRMLGILVEQKRALERSAAARPPAADHLVVFVYPIRPSPPSTCSADTLSDLRTHIDIRAHGIRVVHTRSIRNSGVVVQLYARQDLDQFVNVFKAHPVVSQRYEVKIPFKLDPRVIVFEVDADETTLLKAIEDLVGGEDRRMQIVKKKRTARGHYHYVVSLDGDTFRRVMAEGHLPIDWALYNLTEYDMVKQCFRCGRFGHYLPLCRRERRCQRCGHPAHDGSPCDWPAHCINCHEKNLRDGSQSLPTNHVFGQRTCPVWQAEAQRFRECNIDYENTRKRPAEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTW5</accession>
    <name>A0AAV6TTW5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001067">
        <property type="protein sequence ID" value="KAG8175121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTW5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8771" checksum="7C5A7789C515F747" modified="2024-11-27" version="1">MFSLLISGIAVVVLVVCLWRRSRRAEVLRVLFHRRIRNTRSQMMSNPDYYKDTGENTLCLCTSQLNHYTAADILPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVH5</accession>
    <name>A0AAV6TVH5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_006836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the apolipoprotein L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000919">
        <property type="protein sequence ID" value="KAG8176055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVH5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042157">
        <property type="term" value="P:lipoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008405">
        <property type="entry name" value="ApoL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096">
        <property type="entry name" value="APOLIPOPROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096:SF28">
        <property type="entry name" value="APOLIPOPROTEIN L, 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="414" mass="44790" checksum="2786BB3ECFA6F300" modified="2024-11-27" version="1">MDVKDLFNSFFVSGGFLPLNNREQQLASIVFPVALEAVSKIWDLQQKVSEPLIPDAVGAPVPPANRCHGDFEVKVEAAKENLVKILYLFGKIHNARNEFSSAFPNWTKIRKSNIADLEALGKSLHQDRFNCNVSRLVGSSVGALGGLALVACLFPPVAIVAAPLAIAGGGAALAGGGVVFGTTLTEYGLIKQKMTGAQNILKDDQDCFMSMTKYFEHTIKFVEAVDAVLGFDVLTTLAKDLKDFTNDVTNWDNRFFRQLKRTFTTILTTIQIPLASMGLQLVTVALTIGVIAVLAHCNNCIILDGIILTHRLVFGFLSGLDLGVDVGRALMTFARGGKLTADISNQLSRAVFRGVFGGVGLTLDVINIVLTSIDVHKGSFSKQGKMVLNAADQLSKELEVLEKVYNELKRGPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVM1</accession>
    <name>A0AAV6TVM1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposable element P transposase-like RNase H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001013">
        <property type="protein sequence ID" value="KAG8175396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVM1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="1">
        <location>
            <begin position="140"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="293" mass="33396" checksum="0D1228A7A5193DBB" modified="2024-11-27" version="1">MEDLSICIYSTDKFPKSFKGLFEDNYKCDRWSKFVNLLAQLSKLDKPTELSLFEKVSPAVRVLEKAISELEDFSKSSKLIFMKGQLELLEMKQPRYSPDVLLWSAKLFFAYPAAYLCVRNSKVLSLPHPSYLRKLSHIMKSGVNSDHFLYLKKKANLLKPNERVVNLLFDEIYVDKCIDFKSGHLYELSENADTLATTVQSFITSVFSHNKDIVSLFPVSNMTAQDLHNYCCQVLQMLECGYTVLIIISDNNKLNGKMFSLLAGGGLQCCIPNPQHPEKKLSSYLTAFICLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWC9</accession>
    <name>A0AAV6TWC9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000973">
        <property type="protein sequence ID" value="KAG8175651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="15" mass="1908" checksum="1BC0700B85DF9D80" modified="2024-11-27" version="1" fragment="single">GFIELIVYRRCVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWQ9</accession>
    <name>A0AAV6TWQ9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000869">
        <property type="protein sequence ID" value="KAG8176532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWQ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="140" mass="15446" checksum="D9DE2E39E6000070" modified="2024-11-27" version="1">MIAVVQKSVLSTGSNDSTNMMCMHDHYNDLKKTRMSFFVSIINGVLELFILKVGPQPRSYTIKAANGREYRRNRVQIKVLNNSTQPARQLVDDLFPTISSSPLAAIPPGTSVQPAAQPSATPTSRSGRAIKPPQRFNDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TX74</accession>
    <name>A0AAV6TX74_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_018409</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FIS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000885">
        <property type="protein sequence ID" value="KAG8176419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TX74"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043653">
        <property type="term" value="P:mitochondrial fragmentation involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8176419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="173" mass="19288" checksum="4CFDAC43BB1E9DCB" modified="2024-11-27" version="1">MSNDASNLVMTDDDMKTLLNYNVPADDVETHRRDYETQLASGKHDLQTTFQYAWCMTHSKNINDLKKASVLFEEIFKEGTEDLKRDSLFYLAISETKQRNYCSAKKYIQAFLTVEPTNVQAAQLKNYIEKRLKKDGITGMALFGAAAVFGGVTAIAVGALAVTAALGFSLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TY70</accession>
    <name>A0AAV6TY70_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000896">
        <property type="protein sequence ID" value="KAG8176311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TY70"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8576" checksum="C550D4329C91CF54" modified="2024-11-27" version="1">MAIQKRDEKKATKIKRKRKETRDVQEQSPDSHSEEQTAEMETSLSVVPVEIRNEYVAKRPRREHKPKKVFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0I8</accession>
    <name>A0AAV6U0I8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000734">
        <property type="protein sequence ID" value="KAG8177942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0I8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="150" mass="16197" checksum="5EBCC5FFBC701478" modified="2024-11-27" version="1">MEKSSKLNTLTTRISYELSLLIAKKGSAAGKELIIPAETIICNALFDEKSRRTSAVTASAGDNSLLKQQQFRPTEVNLPQPGGSPPPIPWYAAEGPGMSLQASCPRPVQTALSRHTKSLQFRAGVKSYDPCRAPASPSHILSCIEHHWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1V2</accession>
    <name>A0AAV6U1V2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_021975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000762">
        <property type="protein sequence ID" value="KAG8177676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1V2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF96">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043787074" description="Peptidase S1 domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="32"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8177676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="273" mass="29449" checksum="CBD85564371D1DF2" modified="2024-11-27" version="1">MKMLLSAVVLVSALTLGESLRKEMKKEEVKRVVRGYDAKDGQFPYVIALYDTGNYICTGSIISKTSILTAAHCVVRRGELRPVENLHAIAGVANRSSSKGVFIEFKDFKVHPEYDEQNSDLAILETTAPIKFNDRVKPICIANENIGSLLLSRVAAVGWGQTNRNMTIPELPDTVQYVYQRVTGNLKCQVLYFGRAVPSSGMCATSLLSGICGGDSGGPLVYKLKGAPVLVGMASYVNALTGCGHLLGPAVFTRISSYTKYIKDTATGDVCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3A4</accession>
    <name>A0AAV6U3A4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000658">
        <property type="protein sequence ID" value="KAG8178932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3A4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000032">
        <property type="entry name" value="Fasciclin domain-containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="141"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="273"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="412"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="569" mass="62602" checksum="6D6387B1B24E2AD7" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3N3</accession>
    <name>A0AAV6U3N3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_016515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000664">
        <property type="protein sequence ID" value="KAG8178845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3N3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043708968" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="744"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="4">
        <location>
            <begin position="149"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8178845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="879" mass="98990" checksum="55F22FC99D3738DE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U443</accession>
    <name>A0AAV6U443_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_019699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000682">
        <property type="protein sequence ID" value="KAG8178593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U443"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF12">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50270">
        <property type="entry name" value="NGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043462286" description="Spaetzle domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="6">
        <location>
            <begin position="51"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8178593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="173" mass="19920" checksum="DA1C1B1FC2F22571" modified="2024-11-27" version="1">MRVENLYLMSLLVIGVYCRALDARPKGHKKQRINTDLHQSSPRKRTPLVSECCPSVTEIIRPQGGISKSGRIFELYRDHNSTQSFYQTSCTQGTEGKPCRYVRANSTCVQRYSYTYALVREFDSNAQWRLDYIRIRSGCTCDVTVGPSRKRKRRGRKGRRTFTSDNKGSIPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4H2</accession>
    <name>A0AAV6U4H2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000644">
        <property type="protein sequence ID" value="KAG8179167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4H2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="521" mass="59274" checksum="6F13F11588E0B82E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U621</accession>
    <name>A0AAV6U621_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_007616</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000634">
        <property type="protein sequence ID" value="KAG8179343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U621"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043585791" description="Sushi domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8179343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="276" mass="30673" checksum="C4CE570B3EAE8F79" modified="2024-11-27" version="1">MVIFLMWALVSSEWDIVVSMTIELPECKPPDTPQWGGYGPRESFYFPGDVIHYYCDTDFHIGGNYYRRCEDTGDWIGNTPVCDAPQPFLLVNQSSTADPADQNGADQATDGSRTSCSHTKGGGSESWIGMLQNPGNLFRVMIYLPKMDVAYEVFKIKKDGTEISCGKKVGKVEYLNWEFHNCPSGPNAFNAVGVKIKSLSNEPLRFCEVVAHVLTNPTCVAPHVPIDNGHLEVNRKSANLVCDPEYTPGPDTSLTCVRTGVWNRKRLYCSGSDDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U777</accession>
    <name>A0AAV6U777_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000627">
        <property type="protein sequence ID" value="KAG8179450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U777"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="13237" checksum="E3797D2CD43AC66B" modified="2024-11-27" version="1">MRGRKKREREEKEEKVGKKERKEERKKKKRRREKGEGREGREKERGEVKESREKRKIRKERRKREGEREKGEKEEERKKEVKRGKREEREERRRKEGRRKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U887</accession>
    <name>A0AAV6U887_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aryl hydrocarbon receptor nuclear translocator homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_023666</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000588">
        <property type="protein sequence ID" value="KAG8180048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U887"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18947">
        <property type="entry name" value="bHLH-PAS_ARNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000011">
        <property type="entry name" value="Aryl hydrocarbon receptor nuclear translocator 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="10">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="124"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="323"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8180048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="571" mass="62686" checksum="D4D411B9F7877312" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U975</accession>
    <name>A0AAV6U975_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo repeat-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000578">
        <property type="protein sequence ID" value="KAG8180191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U975"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16356:SF1">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16356">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 6 TMCO6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47014" checksum="AD8C0CE2BE2601F0" modified="2024-11-27" version="1">MAEEASAMDPIQIIRASNRMNLSALRSKDREDLLKQRRVSLLEAESLVADISLPQFKELCLKLKNKKTTFDVLRAIKMSCFSPGRTEAFMKTENALNTLIRVLVGRDARMQLEAAACLTNLVCGSHKASHRIAKACGPYLVSFLGSGSPYLQDQCAWACGNMANCCFPCFTLLKAQGLVPALLANIQSPVPDVIRSTMFALNACTKYVDEDLRDLADDHTVNSLLKLLEREHIHPTAKSDAIFTLSNIIFSLSKNRVEISDSTVETILIHLEKSALKDDFDIKLSLPLVRCLGFASTAKNTCLYIVQELKFKTVVSRILNSNCLHLFQEVICVLTNIIGCCCDLSSDDVDLNAIFRNIHLNTSNHLLIVQVLYFLCSWASRNKNIRIVLLQKEYSSVIEELLSCGEKTVEKAVQVILHIITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCU2</accession>
    <name>A0AAV6UCU2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000477">
        <property type="protein sequence ID" value="KAG8182182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCU2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="13701" checksum="027D019CFC23BA46" modified="2024-11-27" version="1">MARVRSINPFVGGRTIEGQERCQSVVGPIPISPTRPTNGPTKDDEMTSQNGDGFGLMNVHDLATILDAMARTCNPREMEFPRRVGAVMKWPLFAGNSTVAAVERHQAAAYNGSPQRLFFAMPRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UD37</accession>
    <name>A0AAV6UD37_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_018066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000497">
        <property type="protein sequence ID" value="KAG8181758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UD37"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000087">
        <property type="entry name" value="WD repeat-containing protein 26 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054080">
        <property type="entry name" value="TPR1-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21889">
        <property type="entry name" value="TPR1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="7">
        <location>
            <begin position="81"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="306"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="518"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8181758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="574" mass="64885" checksum="8033020ACFBB7E06" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDS5</accession>
    <name>A0AAV6UDS5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nephrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_010125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000466">
        <property type="protein sequence ID" value="KAG8182359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDS5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="29"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="157"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="259"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="359"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="456"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="551"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="692"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="692"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8182359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="84985" checksum="72CB705ADD4A2171" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDX5</accession>
    <name>A0AAV6UDX5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000487">
        <property type="protein sequence ID" value="KAG8181948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDX5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="127" mass="13787" checksum="A6B6E3CD19D47782" modified="2024-11-27" version="1">MSSVGYKTDLHKQTHSIYSNKQLGKFTSANTRTSTPCNGVGSELASCRRAQIKMCSSRCTDPLLKVPPYCHREEEKNQCRLPVGAVPHRIVCSFPSLHRLLLVASGSGSVPLVFAAPFPGQRSNASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEP4</accession>
    <name>A0AAV6UEP4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_025684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000499">
        <property type="protein sequence ID" value="KAG8181711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEP4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="74"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="257" mass="29602" checksum="A80629998A1A7DFC" modified="2024-11-27" version="1">MDNTRGKRLLLVVPKKYRNDLKSFCHEGTSGHLGVTKTKDIFSRHFFWPQCYKEIKDYVRSCDRCQRVGKPFDRKKAPMKIVPVIQEVFSKINVNTCEPLPVTPSGKRYLLTAICLSYKYPDAIPVEDTTSVTVVDALLQIFSRMGFPKVLQLDQGSSFTSAVYSQLCLSFTITVTHESTVFTPAELVHGKNLRTPLTLLYEKWLDVEETEGEPVPVTEYVFSLIKRMKRCQELAISKMEECQQKNKTWYDKRAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEU5</accession>
    <name>A0AAV6UEU5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000458">
        <property type="protein sequence ID" value="KAG8182601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEU5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8629" checksum="9C544B12C32F8E75" modified="2024-11-27" version="1">MHLSFYLGTTVLAEANVRKRSIICQLLQLTLFLTRRHVDQPSALGFLQQSLLTLPATEDVRCATPRTNQEWVSSSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFS1</accession>
    <name>A0AAV6UFS1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-ureidopropionase</fullName>
            <ecNumber evidence="6">3.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-carbamoyl-beta-alanine amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_002065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-(carbamoylamino)-2-methylpropanoate + H2O + 2 H(+) = (R)-3-amino-2-methylpropanoate + NH4(+) + CO2</text>
            <dbReference type="Rhea" id="RHEA:37339"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57731"/>
            <dbReference type="ChEBI" id="CHEBI:74414"/>
            <dbReference type="EC" id="3.5.1.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-(carbamoylamino)propanoate + H2O + 2 H(+) = beta-alanine + NH4(+) + CO2</text>
            <dbReference type="Rhea" id="RHEA:11184"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="3.5.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; beta-alanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the carbon-nitrogen hydrolase superfamily. BUP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.6" evidence="6"/>
    <dbReference type="EMBL" id="JAFNEN010000460">
        <property type="protein sequence ID" value="KAG8182531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFS1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003837">
        <property type="term" value="F:beta-ureidopropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033396">
        <property type="term" value="P:beta-alanine biosynthetic process via 3-ureidopropionate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000008">
        <property type="entry name" value="Beta-alanine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF2">
        <property type="entry name" value="BETA-UREIDOPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="72"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8182531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="382" mass="42668" checksum="92A7ACFEA65F9E12" modified="2024-11-27" version="1">MAQAIDSLEAILEKNIPEGEELNYVKRALFGKELSKLDISPATKQAAIDKNLDLKAFAFSAAPEDLRPPRMVRVGLVQNAIVEETGAPVGRQRDALHKRIREIVEIAAQCGVNVICFQEAWTMPFAFCTREKEPWCEFAESAETGPTTILCSELAMKHKMVIISPILERDEGDVMWNTAVIISDSGAVLGKTRKNHIPRVGDFNESTYYMESDMGHQVFTTRYGKIAVNICYGRHHPLNWTMYGLNGAEIVFNPSATVGELSEPLWPVEARCAAIANSYFTCAINRVGTETFPNEFTSGDGKPAHKDFGHFYGSSYVAAPDGSRTPGLSRVKDGLLVAEMDLNLCRQAKDKWGFKMTQRLQLYSDSFYWACQPDFQPQVNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGJ2</accession>
    <name>A0AAV6UGJ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_018292</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasmic vesicle</location>
            <location evidence="1 12">COPI-coated vesicle membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="12">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000463">
        <property type="protein sequence ID" value="KAG8182401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGJ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000008">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="137"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="14">
        <location>
            <begin position="318"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="15">
        <location>
            <begin position="593"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8182401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="936" mass="105286" checksum="9AE687E3F02C6B45" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJ64</accession>
    <name>A0AAV6UJ64_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">JTE90_010196</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000385">
        <property type="protein sequence ID" value="KAG8184154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJ64"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF41">
        <property type="entry name" value="INNEXIN INX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8184154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="370" mass="42365" checksum="B45E45FC90851417" modified="2024-11-27" version="1">MQTFCSSLRNIFSFRVAEIDTASFRLHYKVTFPILLFLSVLVGWRQIFEVAISCFSRNSDIPGVFVNNYCYTHSTFSYEESWSKSVGEEVPYPGMDKYSSDKTKVHHTYYQWVSLVIFVQSILFLLPRCFWKHVESGRLEELTKELSKPEVVKESFHGQNLIRSTTESSRLLLRSELKRNGGYFASYVVAEVLNLVNVVGQFCLMNIFLGGHFFFYGHQALQFTGLLEPGFKLFPGVAGCNIYTYGSSGDPQRHSIMCLLPINILNSKIYAFLWFWFVFLFIVSCCALVCRCAFFVSSWFRGASLASGNRHLDKKQLQVVVSQISASDCFLLYLISRNISSVKFKEVVSRLAKEDLGAQKFSDDDENTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJB1</accession>
    <name>A0AAV6UJB1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000401">
        <property type="protein sequence ID" value="KAG8183858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJB1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10656" checksum="6448B5C566F866A2" modified="2024-11-27" version="1">MSVLHPNKTYYVPEGTQYLIITLKKCYFVVDKVLAGTEVDGVIPFNENLDYVQETYDVPPPTPPNDWNKRSGIKRHKRLPDMELHSRDEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJU6</accession>
    <name>A0AAV6UJU6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_004562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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            <end position="15"/>
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            <end position="815"/>
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        </location>
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            <end position="193"/>
        </location>
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            <end position="256"/>
        </location>
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            <end position="460"/>
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            <end position="94"/>
        </location>
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            <begin position="172"/>
            <end position="184"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="440"/>
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            <begin position="537"/>
            <end position="611"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="653"/>
            <end position="753"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000368">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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            <end position="736"/>
        </location>
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            <begin position="639"/>
            <end position="734"/>
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            <end position="43"/>
        </location>
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        <location>
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        <location>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="736" mass="81893" checksum="E5F82F686C6D8D75" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UL56</accession>
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        <recommendedName>
            <fullName evidence="9">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
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            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
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            <taxon>Araneoidea</taxon>
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            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000356">
        <property type="protein sequence ID" value="KAG8184885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF435">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8184885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="223" mass="25105" checksum="6D2AA4A15B3AE385" modified="2024-11-27" version="1">MRPSKSQYSSPLHMVPRKDSTDWRPVGDYRALNNQTVKDKYGVPNILDFTAELHGKTVFSHIDLVKAYHQIPINPSDVHKTAIATPFGLFESTRMQFGLCNAASTFQRFIDNVIRDLPSTYAFIDDILVASTTEEDHLVHLPAQQTDDELTKIINSEETSLKLRKQACPFVPFDVVCDVSTGSPRPFVPQQLRKAIFDHFHNLSHPGISSTYRLISSGMFGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPI6</accession>
    <name>A0AAV6UPI6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000312">
        <property type="protein sequence ID" value="KAG8186100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPI6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="236" mass="25948" checksum="4467E960441160D2" modified="2024-11-27" version="1">MPKHTNDTVHILKGNTSAGNEEWSMLCHVTHIRLSRDNGCHVTTAVFATAVKCGGGFGPRFHDRAPEHGTVHGSTTVHRSTVRSTVPLPCTGARYGPSYRSTVRSTVPLPCTGARYGPRFHYRAPEHGTVHRTVARYGPRFHDRAPEHGSVGSTTVHRSTIRSTVPRPCTGARFGPRFHTCRARFHYRGPTTVHRSTVRSTVPRPCTGARFGSTVRSTVPLPCTGARYGPSHRTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPK5</accession>
    <name>A0AAV6UPK5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000326">
        <property type="protein sequence ID" value="KAG8185703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPK5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097060">
        <property type="term" value="C:synaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06718">
        <property type="entry name" value="PDZ_Par6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052118">
        <property type="entry name" value="Rho-GAP_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46150">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 100F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46150:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 100F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="139"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="299" mass="33805" checksum="955B2EA12521268B" modified="2024-11-27" version="1">MSSREKRPRLRRKVKHILFSAMLCCGKRKDARGGDTVEALMSEEGGVIRRVRLRQRPQHTVVVGRDFRKVSGISTEIFRQLEAVENDFDAATAAHLDRVENRGGEMLIRMFDPCALGRVGSDAYRKYTALADGSHVVRFVEIIKRPGQTLGLYIREGDGLRETEGVFISRIALESAVYNSGLLRVGDEVLAVNLVDVSRMSLDDVVIVMSIPRRLVLTIRSRVHSSGTRVRELTRRPTQEGRPPVVVLKKVNLCEFNDEGLCFNVNDEGPCFEKLRIRTLIYDGNDEGARFQKLMMRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ33</accession>
    <name>A0AAV6UQ33_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_000724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000325">
        <property type="protein sequence ID" value="KAG8185738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ33"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17047">
        <property type="entry name" value="Ubl_UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039120">
        <property type="entry name" value="UBFD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057455">
        <property type="entry name" value="UBFD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16470">
        <property type="entry name" value="UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16470:SF0">
        <property type="entry name" value="UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25343">
        <property type="entry name" value="PH_UBFD1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="85"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8185738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="308" mass="33919" checksum="B985A0763649D225" modified="2024-11-27" version="1">MASEENIKETKTCTEQTLEACTTESNNECIIVSSKECFKVPDTGGGDEPENSSDMELGSDSSLQGACGSTDGTPVGSFEEAKELVDFKVIFNKKKHDICFPLDDTVLALKKHFETLIGVPVSMQKVMFKGLCKDEKTLRDVGVTKGAKVMVVGSTLSDVIAVNTPTEQDIKEEKAAAATKEAFCKQKLHKKVLDKGIPEDVQPGIKNAKDALPPYPLSGMVNKSGGKVRLTFKLEVDQVWIGTKERTDKIPMNSIKTIVSEPIEGHEEYHIMGIQLGTTEASRYWLYWVPAQYVDAIKDAVLGKWQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ92</accession>
    <name>A0AAV6UQ92_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U5 small nuclear ribonucleoprotein TSSC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_021785</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus. Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing. Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TSSC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000295">
        <property type="protein sequence ID" value="KAG8186637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ92"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029338">
        <property type="entry name" value="TSSC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13445">
        <property type="entry name" value="TUMOR SUPPRESSING SUBTRANSFERABLE CANDIDATE 4 TSSC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13445:SF3">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN TSSC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15264">
        <property type="entry name" value="TSSC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8186637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="248" mass="28151" checksum="3800E7FF49AADFF1" modified="2024-11-27" version="1">MKKSHIIPASINKRLISTLMATRKVDPKENKDFALKSSSEFASRSGDVFGKLLSLENQHKTWVTENETLECFEESDERFLPEPTKPTGNTLDSKFDSKVKSVIVFRKPDSVPKPDSDAALFKKPYPAKYLKRNAVPSFKKQPQKWTKYSLEDVPISSDATNAKAAFQFLNELKSRKEEKFDPDQDNSSDKIMFKKPKIKERNATARSKTRLPPLTIEELGPDSSNDEDEVLNKCKNSGNVLLAHLKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQY6</accession>
    <name>A0AAV6UQY6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5745 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000307">
        <property type="protein sequence ID" value="KAG8186287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQY6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026619">
        <property type="entry name" value="CEP95"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044039">
        <property type="entry name" value="DUF5745"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22545">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 95 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22545:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 95 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19016">
        <property type="entry name" value="DUF5745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5745" evidence="2">
        <location>
            <begin position="58"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8186287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="693" mass="80309" checksum="4790C5234779F7EB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URA4</accession>
    <name>A0AAV6URA4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_005865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000305">
        <property type="protein sequence ID" value="KAG8186333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URA4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="71"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8186333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="307" mass="34455" checksum="3E59764BBE22D5B5" modified="2024-11-27" version="1">MAKERPFQDSKLLHSSQWMENHYGPKAIRIFVRHQTLKESPTFFPTELLSIKFVQITNFEISFYKTKKEIMIHGIKAEPGLFTFMAALSWSVGDFRVNCTGFVISPTAIMSAAHCLHSSKRDDTLLQANYSAILGSPDRTKGQLVQLKAIMHPKYNRNTKDNDISILKPYVDGDKLPHMDYIQPVYLPNKLPKPEVVYAMGWGKTTFDDCVAAFGETSNILLYHQQRVVKLIREGKQIKVEGDNTDSQGSSTCQGDSGGPLVEIRGDDTMVAIGILSGGFNTGDESYQQIAPHKRFILQHAPDAQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URM6</accession>
    <name>A0AAV6URM6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_024100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000287">
        <property type="protein sequence ID" value="KAG8186854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URM6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000616">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8186854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="274" mass="31122" checksum="D77B9AF3DCDF4422" modified="2024-11-27" version="1">MRFAQLVIGPAGSGKSTYCSTIEKFCEDSRRPCKVVNLDPAAESFTYKTNIDIRELIQLDDALEDEELHYGPNGGLVFCMEYLAENLSWLSEQLGEENDDYVIFDCPGQIELYTHLDVMPRLVAHLQQLEFQVCSVFLIDSQFMVEPSKFISGVMSALSAMVTLETPHLNVLSKMDLLSKHSRKQLDRFLDPDLDLLIQDEQSTSKWGKKFSKLNAAICGLIENFSLVKFLPLNIKDPDSIEELILTIDNAIQYGEDLDVKMRYPDEVDDDMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTQ6</accession>
    <name>A0AAV6UTQ6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_020051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000277">
        <property type="protein sequence ID" value="KAG8187179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTQ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007624">
        <property type="term" value="P:ultradian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038876">
        <property type="entry name" value="ENOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001:SF4">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="320"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="453"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8187179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="661" mass="76883" checksum="93AEBB48041453C3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU05</accession>
    <name>A0AAV6UU05_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome biogenesis protein BOP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_020657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000276">
        <property type="protein sequence ID" value="KAG8187228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU05"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="10">
        <location>
            <begin position="133"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="395"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8187228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="723" mass="82858" checksum="093883DCA221A6C6" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU25</accession>
    <name>A0AAV6UU25_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000274">
        <property type="protein sequence ID" value="KAG8187338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU25"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11514" checksum="563EEA4A5590284A" modified="2024-11-27" version="1">MVEDEIYIEFFNEKFQKLSKENYSLRPDVSMATHPAPHNLLDSGWLSLVIGDSTSTRPAVAAKLKVTCEKMDLEKALSRGSLSSQEESCIGGCNRKNRPKNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU41</accession>
    <name>A0AAV6UU41_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metalloendopeptidase</fullName>
            <ecNumber evidence="4">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_016159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Zinc metalloprotease. Provoques deadhesion of endothelial cells from cell cultures, and also degradation of fibronectin, fibrinogen and gelatin in vitro. Its role in the venom is not fully understood but it might act as a spreading factor that facilitates diffusion of other venom toxins. Alternatively, it might be involved in the proteolytic processing of other venom toxins or it might play a role in extra-oral digestion of prey.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3 4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000280">
        <property type="protein sequence ID" value="KAG8187061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU41"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF883">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043361264" description="Metalloendopeptidase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="6">
        <location>
            <begin position="41"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8187061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="238" mass="27628" checksum="8657534E407CA31F" modified="2024-11-27" version="1">MKYVIILSLFGLTWTFPHSPLENPNLYQGDILGITNQADRNAIPNDSQRWPGGIIPYKIDKTLDHLKEEIEKVMKFIMDNTCIKFTPRQKETDYIRFFYGDGCYSHWGRTGKAQPLSLGSGCDSFGTIIHELMHAIGFEHEQNRSDRDDYLLIFYQNIDPENLNQFDKLKPSQNRLISSFDYDSIMLYGEKTFSRDGRSKTMKAKKKGIKLLDLDKKNKPSGIDIYRINVLYECKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU86</accession>
    <name>A0AAV6UU86_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_001659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the vasopressin/oxytocin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000256">
        <property type="protein sequence ID" value="KAG8187896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU86"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005185">
        <property type="term" value="F:neurohypophyseal hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022423">
        <property type="entry name" value="Neurohypophysial_hormone_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00264">
        <property type="entry name" value="NEUROHYPOPHYS_HORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8187896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="157" mass="18127" checksum="7054BAD0CB2C7379" modified="2024-11-27" version="1">MVKKCYILNCPTGRKSCKEKCSLFKAPKDEELLEKWRHSIPQKKDKVFRSIDYVCEKHFESKCVISRFQPSVNGDYVVDNLRSKLKENAVPTLFPGVEKSDPQIEKYVPEIKPKYVVVSKDNSEDNYVYVDVEVSDSDYVPICFNCLVGNCCLHSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVF9</accession>
    <name>A0AAV6UVF9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000270">
        <property type="protein sequence ID" value="KAG8187511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVF9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11722" checksum="DF65F7EBA6A5D0A1" modified="2024-11-27" version="1">MVSPVERKRWRADKKANEEKKKKEHFLIRILIQKPHLMGICSPRRGEEVTVEISHSPEKGSWLSLDENTPTWSLNSDLAPQSDRLNSKARKVLVGDAEMCATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYB9</accession>
    <name>A0AAV6UYB9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PR domain zinc finger protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_004650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000229">
        <property type="protein sequence ID" value="KAG8188838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001316">
        <property type="entry name" value="PR domain zinc finger protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
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        <property type="entry name" value="SET domain"/>
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        <property type="entry name" value="SET_dom_sf"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
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            <begin position="215"/>
            <end position="242"/>
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    <feature type="domain" description="C2H2-type" evidence="9">
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            <begin position="241"/>
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        <location>
            <begin position="331"/>
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        </location>
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        <location>
            <begin position="1149"/>
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        </location>
    </feature>
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            <end position="1761"/>
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            <end position="1881"/>
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        <location>
            <begin position="1058"/>
            <end position="1105"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1986"/>
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        </location>
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        <location>
            <begin position="1058"/>
            <end position="1095"/>
        </location>
    </feature>
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        <location>
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            <end position="1105"/>
        </location>
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        <location>
            <begin position="1989"/>
            <end position="2005"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022771"/>
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        </source>
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            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8188838.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2069" mass="234218" checksum="B7D629CEF05B9A79" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYF1</accession>
    <name>A0AAV6UYF1_9ARAC</name>
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        <recommendedName>
            <fullName evidence="3">TTF-type domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="1" type="ORF">JTE90_008486</name>
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        <name type="scientific">Oedothorax gibbosus</name>
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            <taxon>Araneomorphae</taxon>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000213">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36400" checksum="8150148B098E310B" modified="2024-11-27" version="1">MTTELSGEKYLATDSKGKENYPNHSSLLDVGIQKIKSVENSASPLSALAQPSLLNTEIRKDCTIEEGSEIPSDVIQIDSAISNNLSNEIAVDQDEISCAKSFCVHAIPTEEDFEQTNPNILANAETNSLKNAHNVSDETVVNLVKSSLHQSLEHENESFGFDLGLLTDDVPISNCLESIVKKGPAKTPSIFSSDGLRSFPISIFHSKRNNGEYNLRDWLVWSKTKESLHCFPCRLFDLHSKSKSILTTCNGWDKDHGWRTLYNKIPTHESSTNHKQCYVQWRKMERRILEGKFIRNQIDTEMIPQRNVLEGHFPTTFVNNFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYS1</accession>
    <name>A0AAV6UYS1_9ARAC</name>
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        <recommendedName>
            <fullName evidence="9">Gustatory receptor</fullName>
        </recommendedName>
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        <name evidence="7" type="ORF">JTE90_008495</name>
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        <name type="scientific">Oedothorax gibbosus</name>
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            <taxon>Araneomorphae</taxon>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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            <end position="397"/>
        </location>
    </feature>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8189535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45509" checksum="5F4FCE05B684764F" modified="2024-11-27" version="1">MGKVDYRINNNIGVSPVVLNVVASNNLKQTWQVKMFCPILNILLFFGLETYHIHEDRRTKILGYLCIRMFYVASAAFAMTGILLVDEILKGISLYSLSTTVILVIGFVFRWALQLKGKAIFGLLCAICDFKGVTPKKLVTTRRRLLIISVLVVVFEGLVLVFLLQKMVESLINSEMNAFDVSKRYSVIFKNAHLGILARLWILSIALIYVHNVIPFCLFGILYAAISWRLRAILKSFKNRLLKSSGPKISECSETYNRICSLVNYTDKTLNSLMFISVFFMSCILYFTVFNMLLPSGDGYVVTPNRIISLLNLIFMVIYLYGMLYFASEIPNVVADISDVIHSMVVDKESVGQKVELLLRVHQGLFLSVGQMVIIRKGLFLVLIGTIATYCLLINSFPLKPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZ82</accession>
    <name>A0AAV6UZ82_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_022513</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000207">
        <property type="protein sequence ID" value="KAG8189700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZ82"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000142">
        <property type="entry name" value="homeobox protein OTX2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793:SF5">
        <property type="entry name" value="HOMEOTIC PROTEIN OCELLILESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8189700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="274" mass="29955" checksum="0E67776002047471" modified="2024-11-27" version="1">MARQPRNLTRAAQEVKSLEKRFAPAPPPRKQRRERTTFTRAQLDVLETLFSKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQNGGSSKSRPKKAKSPPSSSTPPSSRGESPYKPPSLPPPSSAGPVTSNTNTSSNIWSPATISPVAAELMGANSCMQRSYQMAANTPPSCYSSQSYGPASAYHYGNMNMDYLPPPPMPVTTMTSPQMSAPAMMTPGGASHMGASHQTLSSRTPPINGSLPPSSGSDCLEYGSDKSAAWKFQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0Z2</accession>
    <name>A0AAV6V0Z2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_018509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000208">
        <property type="protein sequence ID" value="KAG8189662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0Z2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043349992" description="Secreted protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8189662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16961" checksum="EAC4E988B16096BC" modified="2024-11-27" version="1">MSTFLNVLISVLSVVSIVLLSTVLGSQYSNEDNSVSSSNKRQNNLFVAAMSPLYQPSTTKNQQQQMQQQQQYHKSNTDNTKPDEGGYRIPWMDMVPRRDNRVKRVKKLPGGQSGGGHVPPNVKSSIPVDTEATNREARGRDNNRYDVPLIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1T8</accession>
    <name>A0AAV6V1T8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_014066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000180">
        <property type="protein sequence ID" value="KAG8190590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1T8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8190590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="120" mass="14025" checksum="0E6ABC250DBFA7B3" modified="2024-11-27" version="1">MNSVSRPVSEIIKNQDLDEPKKRSREDWRKAKELEEARKAGNAPAAVDEDGKDINPHLPQYISSAPWYFGAKTATLKHQRPQPDKQKEWSKISDDYVRGLKVKLRFILLLLIMFKWYTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2J1</accession>
    <name>A0AAV6V2J1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_023046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="JAFNEN010000195">
        <property type="protein sequence ID" value="KAG8190074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2J1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8190074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="355" mass="39607" checksum="50C99311C7BFAB33" modified="2024-11-27" version="1">MEVPQFAFADNTDFNADSVEWCPIPQLTQFLVCGTYHLDEGQSGADGTQIRNGNITSYKLLSDPELKLEKADVVDTGGVLDMKWYPKSLNEAAVLGVACSSGKVLLLKVSVDEDTGCLQPFAVVDCSVDEKKMMLSLDWANQEDGSPTLITSDTLGNLNYFCLRDGELCLTESWKAHSFEAWISAFDYSQPHIVYSGGDDCCFKCWDLRNTSNTVFVNKRHSMGVTSISKSKLNEHLLVTGSYDEHVFLWDVRKMKTPISEISLGGGIWRLKWHPSNPQYLLTASMHNGFHAVSISDETLTLKGHYTKHDSLAYGVDWCCQSVAQNEDENLSYSPNVVASCSFYDKLLNLWTINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2N9</accession>
    <name>A0AAV6V2N9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_014400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000171">
        <property type="protein sequence ID" value="KAG8190920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04011">
        <property type="entry name" value="C2B_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04018">
        <property type="entry name" value="C2C_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04017">
        <property type="entry name" value="C2D_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000009">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000026">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000138">
        <property type="entry name" value="Fer-1-like family member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000034">
        <property type="entry name" value="otoferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000054">
        <property type="entry name" value="otoferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037720">
        <property type="entry name" value="C2B_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037722">
        <property type="entry name" value="C2C_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037723">
        <property type="entry name" value="C2D_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055072">
        <property type="entry name" value="Ferlin_DSRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF60">
        <property type="entry name" value="MISFIRE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22901">
        <property type="entry name" value="dsrm_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08151">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2035"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="279"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="440"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="1009"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="1186"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="1547"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="1788"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="146"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="718"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1351"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1397"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1439"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1353"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1441"/>
            <end position="1458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8190920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2068" mass="235693" checksum="1D171DA9CD0C9702" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4F7</accession>
    <name>A0AAV6V4F7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_011879</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000164">
        <property type="protein sequence ID" value="KAG8191196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4F7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="575"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="334"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="529"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8191196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="657" mass="74074" checksum="67CF01C0B49E0605" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V641</accession>
    <name>A0AAV6V641_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SOSS complex subunit A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_010584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Integrator subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000160">
        <property type="protein sequence ID" value="KAG8191409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V641"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056518">
        <property type="entry name" value="HEAT_Ints3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045334">
        <property type="entry name" value="INTS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019333">
        <property type="entry name" value="INTS3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587:SF7">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24566">
        <property type="entry name" value="HEAT_Ints3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10189">
        <property type="entry name" value="Ints3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 3 N-terminal" evidence="8">
        <location>
            <begin position="60"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Ints3-like C-terminal" evidence="9">
        <location>
            <begin position="555"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8191409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="912" mass="104591" checksum="E30F39D12EA717BA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V778</accession>
    <name>A0AAV6V778_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000149">
        <property type="protein sequence ID" value="KAG8191933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V778"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="9037" checksum="59FCF85D1025EBDA" modified="2024-11-27" version="1">MCNIYEQNEPTACAHLFCYFCAYILLEIISHQNIPASFSLHDCGAVQHVNHVQPACGAPPIEERLSKHATMAWGGPSSFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7W3</accession>
    <name>A0AAV6V7W3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000135">
        <property type="protein sequence ID" value="KAG8192790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7W3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="206" mass="23602" checksum="53054C2EF5767224" modified="2024-11-27" version="1">MIAEQMCQTVQPHESICKSTLESIEWPHLTKELILSRPIQSFSSGNEFGDEAKTSKKDVPEKNTSRYLLHMIAEQMCQTVQPHDLVEAPKDNPNFLENDLETCSLGYSVANECTEKFFSRTNENFKTFNNAEKVIHQPSENDMEENEVKPTKISSDFTSKSSASGSVHEHATNERNTGHIMREAHFLRSKFIKVRKFFRSDSKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7X5</accession>
    <name>A0AAV6V7X5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7X5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="8795" checksum="1362CBEC72EAB09A" modified="2024-11-27" version="1">MCTSAHEYFSSAGAVGQRLSRVRKVPRSSPGTTEDLPSICGSTGRLKEYSILHVESEARFCILETQDINEPRPKSKLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V870</accession>
    <name>A0AAV6V870_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V870"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="95" mass="10114" checksum="CC7A327F5D6241A5" modified="2024-11-27" version="1">MEIFSCPSSLNLRSYFLAIIIGVLANGTIAMGTSGSNMYDQLRNNSRALISHLWSRVEGFGCCLGSVLFIFGALGGVAGLDDGDIWVFMRFGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8J0</accession>
    <name>A0AAV6V8J0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000141">
        <property type="protein sequence ID" value="KAG8192279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8J0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="465" mass="51679" checksum="9F9A4EF234B13678" modified="2024-11-27" version="1">MTSTFENQTILKKSIVPNSDSTSETESDSDSESNSESVSTKAIENKILISNSELNYCTSNSGNTTHLKVNPILQEKLKKEILMSKSEINALPQSIPKTETVPQNLTPTKELSYNSETDTDTDSDSDSNLLINKKVILNPLLLQPKMNSVAKSNSDIKSIQTQESETSIKENESNSDSDSSTNNDSSSDSKPIIKKEKLPNNLVLQKQLNSPLKSNSCIKSIQKKEQENIICESESNSDSETYSDEESNSDSKPILKENALPKNLERQKELNFKPKSNSGIISLQKKEQKTFISESESNSDSDTSTDNDSNSDSKPIIKKEELPKNVVLQKELNSRPISNSDIKSVQTKEQESIICESESNSESETSSDEESNPDSKVIPKKEELPKNLVRHKELNFKPKSNSGIISIQKKEQKTFISESESNSDSDTSTDNDSNSDSKPIIKKEEIPNNLVFPNELNSRPKSNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8Q8</accession>
    <name>A0AAV6V8Q8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000134">
        <property type="protein sequence ID" value="KAG8192877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8Q8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11668" checksum="5EBFE9EE051CAA1F" modified="2024-11-27" version="1">MMTRFDCGSGQHHRHIIAALIDYWVAISIRDCYVISIIHAKDGWSAGWQRRIGRPHESSSKLPADNVPRIVSAVQSRSIDTRVMMAVNASEYMSRVVDRVVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAD0</accession>
    <name>A0AAV6VAD0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor TFIID subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_025632</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000133">
        <property type="protein sequence ID" value="KAG8192924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAD0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000243">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="11">
        <location>
            <begin position="125"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="382"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="455"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="497"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="539"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="581"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="623"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="301"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8192924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="727" mass="82120" checksum="DEB0F8B4641D5745" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VB88</accession>
    <name>A0AAV6VB88_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L32, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_003779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the mitochondrial large ribosomal subunit (mt-LSU). The mitochondrial ribosome (mitoribosome) is a large ribonucleoprotein complex responsible for the synthesis of proteins inside mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000125">
        <property type="protein sequence ID" value="KAG8193292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VB88"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8193292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="201" mass="23526" checksum="DF68E9D734D48D4F" modified="2024-11-27" version="1">MSIIQAAFRNWRMLIGRLFPGSMNQSTHFPELCLADIGNPETTNRKSPRSLLEDIIGNGFLWAVPKKRRSLERRMTRRMGFGKLILPRNNVVVCNDCGHFHLVHTVCGNCYEKVKEETKYMQEAVFKELKLDPINKEVVILYENDRKEEKLFEGKRIVEVPKERPQWFSKNLLMKDSGIPRRRTTDIRDSAFTVEVKEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBN9</accession>
    <name>A0AAV6VBN9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_017834</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of 2 subunits, IMMPL1 and IMMPL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000131">
        <property type="protein sequence ID" value="KAG8193083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBN9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="12">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8193083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="116" mass="13019" checksum="513737619E56056E" modified="2024-11-27" version="1">MMCIVYCSCPRDPDQKLIKRVIAVEGETIKTSSRGHKYVSIPSGHCWVEGDHMSHSMDSNFFGPVALGLIFAKASHIVWPPSRWQRLDSSAPIGRHPVSWPRPDLAALSWGFEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDW8</accession>
    <name>A0AAV6VDW8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dual specificity/tyrosine protein phosphatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000109">
        <property type="protein sequence ID" value="KAG8194120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDW8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dual specificity/tyrosine protein phosphatase N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="126" mass="14371" checksum="CF0BE65C9A2A2860" modified="2024-11-27" version="1">MDTLNQNIIVHVAEFIKDRLYFTTIQDKKRPRISVAHHYFCIDEEFVYNSFYADFGPLNLAMVYRYYCKVNKKLKVNCLHSTFVSVSEGSVASESPLAPSGLEIPAYSLTLCGVCLLITSLFWTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF80</accession>
    <name>A0AAV6VF80_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_003125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000101">
        <property type="protein sequence ID" value="KAG8194653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VF80"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF0">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="620"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="638"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8194653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="683" mass="78130" checksum="C833337ED60392EB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFH7</accession>
    <name>A0AAV6VFH7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_002181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000084">
        <property type="protein sequence ID" value="KAG8195555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFH7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1660:FF:000002">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide chain release factor" evidence="4">
        <location>
            <begin position="76"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8195555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="375" mass="42763" checksum="5E80DD18552F63EC" modified="2024-11-27" version="1">MTCRYSLHRLSESVSFEDQRLQKHLKFLSDLCKEHIGNSKPLKESLGISYKALNHIQYLLNEIEKTKEEITEVDLLISDLKDSKDELYNVALSEKESFQHKLNVLQDQLLPLMVPVDAGDEKDIILEISPGVGGQEAMLFAKDMFHMYCHYATYKGWRHEVLKYDTTELGGIRSAHLGINGAHAYRVLKYECGVHRVQRVPKTEKAGRIHTSTTTVAVLPQPSEIDIVIRPGDIELEFKNSSGAGGQHVNTTDSCVRIYHKATGLVVESQVSRDQHRNRQVALTSLRAKLYERELMAALKEETLSRKSQVGTAARSEKVRTYNFVQDRITDHRAHVTLHDVQRFLGGEELFDHMSHLLQHWGDTQALQDVLHKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFJ3</accession>
    <name>A0AAV6VFJ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000103">
        <property type="protein sequence ID" value="KAG8194426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFJ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="10411" checksum="5A20F4C23692E3F3" modified="2024-11-27" version="1">MEIPLKEQQEQKGAEGRGGTFISILQQSYELLGMFHKPIYEWTKEENRYAAPCLLRSLGGWEEGFLLSILQQSYEFHKSIEEWTKWEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHE4</accession>
    <name>A0AAV6VHE4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_019512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000085">
        <property type="protein sequence ID" value="KAG8195523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHE4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043484869" evidence="2">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8195523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="136" mass="14367" checksum="066BD00E3619E7FC" modified="2024-11-27" version="1">MFYRLGLTSLYLLAISTSVFSKSLNPGLHADISNQRPADAMSSRQLGGGLSALGTLISPLLFLMGMGSFVSMLPQMFQTVLSGVGSNLIQSFTGAGGASGGASSTRLKRDVEEELLGEIEKRLNLALLNYEGHRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJJ6</accession>
    <name>A0AAV6VJJ6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_023797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000073">
        <property type="protein sequence ID" value="KAG8196238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJJ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="45"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8196238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="297" mass="35015" checksum="6A9F7AC133F5FD2C" modified="2024-11-27" version="1">MANFVDIGTEAKEERTFTVAGSKFPISTLFQKDNITTALIFQPQPRDVIVCSYPKCDSKYVDIIVWKLLYPNCKLPLINNITNRFVLSMEMVDMQELLMRQKSPRLVKTHLPLQLISFYKRAKYIYIIRSPWELSVSYYKLLWSIGNFNESFDQFLTLFLEGNLGFDCYFNHVRSWSRRIEDENVLILCHEHVRNNPRSALFCIAAFLGEHYLKQVLQSTELEKEILKSISAEKTKSQRYFLKSLKQRSFRKPTCTEKQMSEILMKVSEKFSNTAVEHMWLNLLKKYEQLVSRGQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VL78</accession>
    <name>A0AAV6VL78_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_006547</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:74111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:74112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:69819"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:69820"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:31979"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15724"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.14.13.148"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:31980"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="JAFNEN010000066">
        <property type="protein sequence ID" value="KAG8196637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VL78"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034899">
        <property type="term" value="F:trimethylamine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000159">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0274">FAD</keyword>
    <keyword evidence="4 18" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="10 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="28"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8196637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="759" mass="87038" checksum="11955F361DCE42AF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLB7</accession>
    <name>A0AAV6VLB7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLB7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="114" mass="13219" checksum="B87583503B1277CD" modified="2024-11-27" version="1">MIACRFVITTKVRRKLVCEAGLLVPTMSNWIIDWKMLWMSLLQRTGRSIRDLGIGKGEERGGLLNDHFEKFRLAVGLFLVLYKLQNMASSIYYVRCVAHKCVVECKVYLEFESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLJ4</accession>
    <name>A0AAV6VLJ4_9ARAC</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_004349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000059">
        <property type="protein sequence ID" value="KAG8197083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000827092">
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    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
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        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF1">
        <property type="entry name" value="RE15579P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="10"/>
    </dbReference>
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        <property type="match status" value="11"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="2262"/>
            <end position="2284"/>
        </location>
    </feature>
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            <begin position="59"/>
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    </feature>
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    </feature>
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    </feature>
    <feature type="domain" description="Apple" evidence="3">
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    </feature>
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    </feature>
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            <begin position="1007"/>
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            <begin position="1273"/>
            <end position="1520"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="2017"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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    </feature>
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        </location>
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        <location>
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            <end position="2149"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2213"/>
            <end position="2222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8197083.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2338" mass="263412" checksum="D91069CA4C8918ED" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMB5</accession>
    <name>A0AAV6VMB5_9ARAC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
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        <lineage>
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            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
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            <taxon>Linyphiidae</taxon>
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            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000050">
        <property type="protein sequence ID" value="KAG8197789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="117" mass="13709" checksum="AE577A1C0CA519C4" modified="2024-11-27" version="1">MMDTLDLEDDRSYINDLQRSKLAFNLLDSPYLEGANPYQSTAIAVKKESWLRRFFDACSCYRKSKVKEEEKSEAYISFNPNFNPCPSIGSTDGPKKRKTDMFKEEKSDLNFFKDIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VML8</accession>
    <name>A0AAV6VML8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Lymphoid-restricted membrane protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">JTE90_027516</name>
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            <taxon>Araneomorphae</taxon>
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            <taxon>Araneoidea</taxon>
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            <taxon>Erigoninae</taxon>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
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                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="PANTHER" id="PTHR15352:SF1">
        <property type="entry name" value="KASH5-LIKE COILED-COIL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15352">
        <property type="entry name" value="LYMPHOID-RESTRICTED MEMBRANE PROTEIN, JAW1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MRVI1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="174"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8196796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="52265" checksum="E6CB4C5C3C302057" modified="2024-11-27" version="1">MTDNQTSDQDQQITSIADAVVKLKELRESNKNLNEPDIEEKYAQLSLAFKTDKFTLGKRLDLQLRQRDIAEKNIESELRALRESLNALNQLCTESDMREIITKTQQHVDIVQQATMRMSSRAETYGAIQQEQRMNCAFETMLNYVEHLKLLYDKEHLELEEYRRLLAEHNLLPREEGKAHHDDDPKRPTLPPRSHSLSSSSKPELLRRGSVGTVIRSMVIDHDKLGREINPGWSLSGVRHKLESRTRLLSAVCLLNNNFESSRGAALNSGQVSPKSRRSSLPVGPLAQAGRVTHGSISERKDSQASKLSRESKLTRTESEESTSSKPESDSAPCPQLQEQPEEDAPAAELNDSSEVALPPSPEDIDEEESSTSLACSMQESACDNNEEGDVCLLPEIRVPVRTKHFYVLDFVQKVSIRRIWRWDNNTTTTVILHARYALSAILATAAMLTLVLTFIPNQVLAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRP5</accession>
    <name>A0AAV6VRP5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_011776</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ALG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000028">
        <property type="protein sequence ID" value="KAG8199309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRP5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041549">
        <property type="entry name" value="PssD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8199309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="176" mass="20520" checksum="EC2229614E524940" modified="2024-11-27" version="1">MMVTLGSGGHTYEMFQLIRNLSYKIQPRIYIIAETDNLSEHKLQDFMNSKYSKLSTELNIIGKIPRSREVHQSWITTVFTTFRAFIYSFILMMKHKPDFLLCNGPGTSVPLCVAAFIFHVLGWKHIKIVYVESICRVKTLSLSGKIVYQIADRFFVQWPQLKDKYPRAKYFGKLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRT9</accession>
    <name>A0AAV6VRT9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000042">
        <property type="protein sequence ID" value="KAG8198221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRT9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="106" mass="11646" checksum="3BCF8BFEE581A2A1" modified="2024-11-27" version="1">MKKLQEIQIELPQLLMKITVQENKSLKRFPSESEPDDATCNILPEAADVLDSKMDSLCSVSQSNSSVLEGKGNSSYEVSSIRENLNVKTASPPEMEVEICSSPEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSF8</accession>
    <name>A0AAV6VSF8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_007077</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000035">
        <property type="protein sequence ID" value="KAG8198767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSF8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001276">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF63">
        <property type="entry name" value="EARLY GENE AT 23, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="677"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="23"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8198767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="706" mass="79408" checksum="77DCE8F2C407162F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT05</accession>
    <name>A0AAV6VT05_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein tyrosine phosphatase type IVA 3</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein-tyrosine phosphatase 4a3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_000917</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with tubulin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT05"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043542">
        <property type="term" value="P:endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000105">
        <property type="entry name" value="Protein tyrosine phosphatase type IVA 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="10"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="84"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8199829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="171" mass="19740" checksum="B7B88050F88F71A3" modified="2024-11-27" version="1">MKQKIMLRTPPSEIVFKGMKFLILDRPTDATMVTFIEELKRKKVTEVVRVCEPTYKTDILEKHGIKVLDWQFDDGFPPPAKIVHDWFALLRTRFNNEENADCFVAVHCVAGLGRAPVLVAIALMELGMEYEDAVELIRQKRRGAINAKQLSYLKEYRAKNRLRGSKQCCIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT82</accession>
    <name>A0AAV6VT82_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Down syndrome cell adhesion molecule-like protein Dscam2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_023473</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000036">
        <property type="protein sequence ID" value="KAG8198701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd20956">
        <property type="entry name" value="IgI_4_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20958">
        <property type="entry name" value="IgI_5_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000017">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000104">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000324">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000719">
        <property type="entry name" value="nephrin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056754">
        <property type="entry name" value="DSCAM/DSCAML_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25059">
        <property type="entry name" value="FN3_DSCAM-DSCAML_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1330"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="50"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="157"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="251"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="348"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="438"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="535"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="626"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="722"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="819"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="921"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="1020"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="1120"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="1214"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1417"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1469"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1473"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1486"/>
            <end position="1498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8198701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1606" mass="178882" checksum="3B713ACEFBD61A67" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTW2</accession>
    <name>A0AAV6VTW2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_015982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="JAFNEN010000030">
        <property type="protein sequence ID" value="KAG8199149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTW2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="119"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8199149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="366" mass="41538" checksum="08941388ACC350D7" modified="2024-11-27" version="1">MGSKCSFCVRLFKWFPVVFITSIVAWSYYAYVVQLCFFAVESIIEKIFYLILFHASFAMFSWAYWQTIFTQIGTVPRQFKLPPADAEQLERDHSEDNQRRLLESFAKDLPVSCRTLNGSIRYCDKCRNVKPDRAHHCSVCGVCVLKMDHHCPWVNNCVCFTNYKFFILFLGYALVYCLLISATSLQYFIRFWTNQPEVPGRFHILFLFFVSVMFAVSLVSLFGYHCYLVSVNRSTLESFRPPIFLTGPDKDGFSLGRKANFAEIFGEVRSKWLLPVHSSLGDGVTFSTRAQAGSSYNSMGNTNPASHGDGVGFPQKVVDEVSGGLLDERTNWVEDEIDDSGKVAFGKLYESASRSSIASDIKLLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUX2</accession>
    <name>A0AAV6VUX2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUX2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="128" mass="14280" checksum="9E6F1221D671CA06" modified="2024-11-27" version="1">MRTQPVDDGQGYAKDVSEAQERGHLPAAKVESIGPQTSALGVGPAKGYRLLRVPRDHCLRRVPGTPLFPSIHCFPLPPGDSSVSEITKDDRPTHTTVLTEIHFFHPYIVSLKQHFCPPLFRKEFKLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUY6</accession>
    <name>A0AAV6VUY6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_009458</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUY6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001927">
        <property type="entry name" value="Zinc finger protein 1184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8199623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="111" mass="12878" checksum="97C2C277EC0FDE6D" modified="2024-11-27" version="1">MGMQRSLLLPSTVNFLYSHDPPKGKVYKCGFCSYTTVHTTCLKRHSVLHTGERPFKCSVCNKSFTQAHVLRTHMLIHTGQKPFQCEVCLENFRHAKSLSRHRHKLMHFPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VV77</accession>
    <name>A0AAV6VV77_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_022131</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000025">
        <property type="protein sequence ID" value="KAG8199681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VV77"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000002">
        <property type="entry name" value="Cyclic nucleotide gated channel alpha 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032406">
        <property type="entry name" value="CLZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF11">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16526">
        <property type="entry name" value="CLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="419"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8199681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="625" mass="71833" checksum="8AD28877A069217B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVW5</accession>
    <name>A0AAV6VVW5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras-like GTP-binding protein Rho1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_015868</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000023">
        <property type="protein sequence ID" value="KAG8199877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVW5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000095">
        <property type="entry name" value="Rho-related GTP-binding protein RhoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8199877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21895" checksum="5CB9225AF08DB216" modified="2024-11-27" version="1">MANIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDLKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIMEKWNPEVRHFCPNVPIVLVGNKKDLRQDTSTIKELAKMKQEPVKPEEGRSMAEKINAFGYLECSAKTKEGIREVFEMATRAALQVKKKKKKKCILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWS5</accession>
    <name>A0AAV6VWS5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000011">
        <property type="protein sequence ID" value="KAG8200890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWS5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="82" mass="9173" checksum="27F16B30097F3A6F" modified="2024-11-27" version="1">MLTNAGGCMPELTPCCRQATLTTRLTGCRSFAGNGRCSAFRWSTRNDNTPPDIDQSNNEVLWGSRFGGRLLIEQQRRSDKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWX7</accession>
    <name>A0AAV6VWX7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein odr-4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_000671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODR-4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWX7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029454">
        <property type="entry name" value="ODR-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33966">
        <property type="entry name" value="PROTEIN ODR-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33966:SF1">
        <property type="entry name" value="PROTEIN ODR-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14778">
        <property type="entry name" value="ODR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8200603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50255" checksum="C330BDFF427AF8F6" modified="2024-11-27" version="1">MGRIITFDNHVQETVNTITKAKTIHLGLIIGQCTEQKDIVLHLCPSPKKDEPPDSDTAAPKQSKNKSKDVIDLDEKWICQHAKQLLRTLPGGLDILGLYVVASADNSTKQQAQLRQILFAIYKTLGKSQSLDLCSHERVLLSICPTTFKVICRTYDIADFKCSANPADWKLQSGNVRWQRVRCQLAVDIKFPIQTENGTLSLRKQIEMGLQSFLENIKEAHALVNGLQRDVEDPLDASADSKKSKKKQADREDSSVLPQWHNIELFVPLKIKEIADPKVLDCVCMMTFKGAVQCRAYIHGKASVGDAINALKQDIVRSIIARCEIHCEDLLVIEEEQQDPLVVHELPRRVFAPLPQGDVCVCDYQFHSDTASDSLDAFKELLNLDLTEEDIDTSCEVSPTTSTLILPDAVEDRLSEFGDAPVKSSFNVYIPIAGVVATVAIGLASVYMASQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXV9</accession>
    <name>A0AAV6VXV9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_024312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXV9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8201442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="128" mass="14125" checksum="5A802BDD577CA6CD" modified="2024-11-27" version="1">MDGGSNVQAMVDILVGPKKFVYCFAHLLNLIITDGLTDANNKRLAEVLTAVKAIVTFARQSHVFMEKLREKQESAGVVESNVMLLVQSVPTRWNSTYAMLCRFVAMSPLVAAVVANPLIKKLTCNDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VY94</accession>
    <name>A0AAV6VY94_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box/LRR-repeat protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_012678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VY94"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22125">
        <property type="entry name" value="F-box_FBXL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000051">
        <property type="entry name" value="F-box and leucine-rich repeat protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000059">
        <property type="entry name" value="Partner of Paired"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047932">
        <property type="entry name" value="FBXL14_F-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="96"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="210"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="286"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8201604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="43905" checksum="70FE20ABA3A5A985" modified="2024-11-27" version="1">MEGNERPAAHVSCLYPEILALIFSYLDVRDKGSAAQVCAAWREAAYHKSVWRGVEAKLHLRRSNPTLFESLVQRGIRKVQILSLKRSLREVVAGIPNLESLNLIGCYNLTDLWLTQGMVQEVPTLSVLNLSMCKQITDHSLRKISECARNLQVLDLGGCSNVSNSGLLLIAWGLTGLRSLNLRSCRHVSDAGIGFLAGSGSHMAEGTLVLEHLSLQDCQKVTDEGLKHLSVGLRHLKSINLSFCAGVTDSGLKHLARIASLRELNLRSCDNISDTGLAYLAENNSRISMLDVSFCDRVGDQGLLHVSQGLFNLRSLSLNACPISDEGLGRIARTLTDLRTLNIGQCSRITDKGLSLVAEHLLRLFCIDLYGCVNITTVGLEKVMQLPQLSVLNLGLWQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W1E8</accession>
    <name>A0AAV6W1E8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_027433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W1E8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043585825" evidence="3">
        <location>
            <begin position="25"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8201958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="451" mass="48539" checksum="3EE95E14679F3B2E" modified="2024-11-27" version="1">MAMLFKIAAIVCILVIGAIPILRAEDDEDATHETAVKTVVYTIEPTPAPETATEAVNGTSAGSPWGGLFSASSQVVRSVFALEVCLFAGFAFYLVVIFSCCLLILSILQNADGFTVAVVTIPEGATDINTEIATLREKLNEKIKEALSGTKMVKVVMHPISLIVFLLFEVLMGAETAEMLSKTQNELASVHVNEKTILSDPKTLTNKSPPGEAAKTPLEASLIAAMASEDIKQDKPGASEVDPKLAKGVVEMKENLKYVKSENPEVPENATKSFVPVETESLPSLRMDHFVEKVTIPQVQKEKGVNSKDKKMEEVAVDSAATLDSGPFTTDNHSTSKSEVTTGQHSTTELEIEAAKTMISNSKTTKASPGVITGKIPTEGKGKMISSKLPRVETSIEGKNPQEACQKDRKMVKFESSQSNSALRSINNPLEYVILNLAMVVILLQLLNGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDF9</accession>
    <name>A0AAV6TDF9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006429">
        <property type="protein sequence ID" value="KAG8155955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDF9"/>
    <dbReference type="Proteomes" id="UP000827092">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="101" mass="11135" checksum="5886BDF1AC830148" modified="2024-11-27" version="1">MVGPHPTIDSFDKADLKDNVAGTSSPLHPCDQPKEKPFPPSRDPHPSKAPVFDIAPRNIAIKYNTKRRTLSRQTGSRLPRPALLLRGRGNNKGKKNVTTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDQ8</accession>
    <name>A0AAV6TDQ8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006559">
        <property type="protein sequence ID" value="KAG8155837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDQ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
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        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="497"/>
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        </location>
    </feature>
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        <location>
            <begin position="518"/>
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        </location>
    </feature>
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            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
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        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="691" mass="78562" checksum="9D423FF1D22A627F" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDY0</accession>
    <name>A0AAV6TDY0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006270">
        <property type="protein sequence ID" value="KAG8156154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDY0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8156154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="193" mass="21850" checksum="BD0F54AD9BEC7F04" modified="2024-11-27" version="1" fragment="single">CSPWGTCRKGTDRPKITLLPRFSRPKRRPGHRKTGGFLREQGPYLRRPIPGKELLQEKIIFPRVPVDSPSFGSLPHWGPKDLSPCRGLGKINPSLLVAREKHEHVFCVFGQTSASERVSSDPLDRLTHFQLLSQKPFSSFSPQGLPLSFLHFYPKISPGRLPRAHARDLKRTPPRPSYSLRLNLHRALPYGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGD7</accession>
    <name>A0AAV6TGD7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_025223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004715">
        <property type="protein sequence ID" value="KAG8170895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGD7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8170895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="8782" checksum="2E7236B1CB1CCF17" modified="2024-11-27" version="1">MLNISVDACFKKPCGTSLICNDNGDSTYTCSCKEGFMYNGKRCIKMDKCAMGINCEQLCTNGLCSCAEGFYLNSDNATCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGE0</accession>
    <name>A0AAV6TGE0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005200">
        <property type="protein sequence ID" value="KAG8170566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGE0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="9333" checksum="0430285C2E844432" modified="2024-11-27" version="1">MGTAGTKITLSPSDFKRANRGAPDTAETSVLFTENSAYYSPGRADSGHELLQRKDNLFPGSSVDAVSSSVALRTGPRRTLSPGRVGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJW8</accession>
    <name>A0AAV6TJW8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_027985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003411">
        <property type="protein sequence ID" value="KAG8171903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJW8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047134">
        <property type="entry name" value="RNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041:SF78">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="191"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8171903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="253" mass="28961" checksum="457B595420AF76AE" modified="2024-11-27" version="1">MAEELYRAVALEPAPISEGSAEESDASDLQRDQVETSNHAPSEIASAVTLEPAAPISEGSAEESNASNLQGDQVERSRTIRLPRTMLRTMRRRNNAPSETASSVGIHPLHNVASHSRNAEPAIEEDSAFLENNTNTRFRWLKPYYQPRHFLWPRDRPRRRIVLDRPRVEPRTAFKLQTVKFTETQLNEEQCTICLTSAREYKLNWRPVARTSCGHLFCVPCIYCWRKESLACPICRRVVLRPEDRGLILFHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKT1</accession>
    <name>A0AAV6TKT1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_022559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003000">
        <property type="protein sequence ID" value="KAG8172184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKT1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8172184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="134" mass="15841" checksum="AE6E93733748B53E" modified="2024-11-27" version="1" fragment="single">SLELLSVIGGYMGIYLGISLLAIYDFAEILARKLYSTLKRRQKRRNKMDVNQSQISSRWVRIVRQRHQSGVFRKRPAKIHPHRRRQKQDYFPKTIICAKIFPEDLVKRISDSTRPSRDDRNKLDVTKSQNTSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMB6</accession>
    <name>A0AAV6TMB6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_011717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002069">
        <property type="protein sequence ID" value="KAG8173100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMB6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8173100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="205" mass="22739" checksum="D489BC431AF92290" modified="2024-11-27" version="1">MNSKNDSTPSTRVSRPLYSQVLASSSNATITGVVTSTMSIHSGISLATSSIPNNTGFFATESRHRCKICSKTFHSSYNLKRHMKTHEAAKKPSMVNVDASTSRVQALVVQNAVPSPTTVHSCVICYKSHAKTHENEEYVCPKCSNSFTRKDVLTRHLTTHNKPVKRQQPHNQPSTSTPKRRRAEKVADVFATHTIYPSLRRAKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPP0</accession>
    <name>A0AAV6TPP0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001479">
        <property type="protein sequence ID" value="KAG8173815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPP0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="250" mass="27630" checksum="E7068FD967D6D2C9" modified="2024-11-27" version="1">MAQFNFVAELSTQEIIEKATANGSRNFVIFLENKSGARIRYKKLVLDKPTFAKALTGERQKGIDIQGEIHKAIDKAIEPLILQLDKVIKKLAETQLKTFECLADLSRQVGSLATQGALQQPSAKILTLLIQKVELLPKQTTQQQKIVESLKPLQNTGAVNTTLAAKTHLPNTKNAPSLRKERDDPAPAETENKKAKLNCNPLKLPQTTPSIHEPSDEPSAMETNQRHDAGTDTAKIFCHKYATQPITFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQ78</accession>
    <name>A0AAV6TQ78_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001304">
        <property type="protein sequence ID" value="KAG8174150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQ78"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9793" checksum="3E011B1713A20A35" modified="2024-11-27" version="1">MEPNNVNASHNVTHVIVTKGPPVTSKVRRLAPDKLKIAKAEFDYMLEHGICRPSSSPWSSPLHLVKKKDGGWRPCGDYRALNDLCIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQC3</accession>
    <name>A0AAV6TQC3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001333">
        <property type="protein sequence ID" value="KAG8174079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQC3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27218" checksum="3AD010121074DA03" modified="2024-11-27" version="1">MRRMMKLTCDGVGLQEAHKVPTASEWVLEGTKLMSGRAFINAIQVRTGTLYSRARAARGRNIPHQCSRGCSQPETLNHILQNCYASDKLRIIRHNRLVEYIHRGAQQRKFSSHVEPEFSLPAGKLKPDLVLYREDKAIIVDAQIINDQYPLEKANQNKIEKYTPLLEFDLKDMDASVLAFTINWRGVICKSSAESLIREGILRKRDLKILAVRTLEGGVVCHRVHQKMTTSRRVKKGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQY1</accession>
    <name>A0AAV6TQY1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ZSWIM3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001263">
        <property type="protein sequence ID" value="KAG8174277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQY1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048325">
        <property type="entry name" value="ZSWIM3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21599">
        <property type="entry name" value="ZSWIM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZSWIM3 N-terminal" evidence="1">
        <location>
            <begin position="60"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="166" mass="18607" checksum="AB5C510AA5CA858E" modified="2024-11-27" version="1">MSDNDLSLAVTNDNDLERQSTDDLALDTIVLPFENVSNDNDLERQPTDDLALDTIILPFECGKSFTTYSELEKVVKAYENTHFAVLVKVKSEKWPEGHKNRETLVYKTLVYACKKGQNRHKSEAKGIRPNVTSGKLGCRFKLKISSNRGALVVKEAALDHTGHELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQY5</accession>
    <name>A0AAV6TQY5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001324">
        <property type="protein sequence ID" value="KAG8174093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQY5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="52" mass="6042" checksum="5FF7C2A586B3070C" modified="2024-11-27" version="1" fragment="single">QNKSCPTWPSTAQWRRVVTSDEFLYHFSEDLEDLGTVRTWPIEDEGRLLGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRC5</accession>
    <name>A0AAV6TRC5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001186">
        <property type="protein sequence ID" value="KAG8174582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRC5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="146" mass="17403" checksum="462DD2AEE3C6DCE5" modified="2024-11-27" version="1" fragment="single">SQFFGPKSWFSYPPCYASFGSVTRWMIHNGSNTMLLEIKCTFNVDRLELEELAERSNFCLVKTEGQWELKRSHSYYYQVQRQLALSNLTECVFALFYKPPNCVHTEIISFDRNFWLDMFEELNEFYLRYYLPALMAPEVDPAEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSF6</accession>
    <name>A0AAV6TSF6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001097">
        <property type="protein sequence ID" value="KAG8174987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSF6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="145" mass="16657" checksum="99CBCAE3D13D3ADA" modified="2024-11-27" version="1">MNPYSLKRCVLENYLCSFGTENGLSEKKCHRFAGVNTQFLLKVYYPENFRRPEQQKRGTFKIEEQKGRENKRTTSAGCDVITPHSELRIPVRGENGGSPCRVDHQMCIGIFNERLIIPLFFSFFAGRLADLVELSDSKSKRSSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSQ9</accession>
    <name>A0AAV6TSQ9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_018814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001207">
        <property type="protein sequence ID" value="KAG8174470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSQ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000255">
        <property type="entry name" value="Sushi, nidogen and EGF-like domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="713"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="392"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="430"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="465"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="588"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="666"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="674"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8174470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="774" mass="85088" checksum="A91CD2AB651A09CE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TT57</accession>
    <name>A0AAV6TT57_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_007777</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:60648"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:143891"/>
            <dbReference type="ChEBI" id="CHEBI:143892"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001182">
        <property type="protein sequence ID" value="KAG8174601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TT57"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006580">
        <property type="term" value="P:ethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320:SF1">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GP-PDE" evidence="8">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8174601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="138" mass="16393" checksum="6C0A6978D8910BF8" modified="2024-11-27" version="1">MFSKHRELYQQAVVASFFPSFIYQLRRVDPAIVTALTFRPHFMTLTDIPNGKPRHDSWWRHQVARIGDVVLEWSFHNLVWYLTGSSAVLIHKDYLSGEYVRMWRNRGLHVIAWTPNHRLEKEYLRKVLNVTSITDTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTU8</accession>
    <name>A0AAV6TTU8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_027492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001095">
        <property type="protein sequence ID" value="KAG8175011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTU8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="86"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8175011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="148" mass="16722" checksum="307A1952D7D389B5" modified="2024-11-27" version="1">MRMSIPPKEMLAITLRYLASGCSLTDLFFTYRIGVSTASIIVQTTTERIWQCLAKLHFPEATQENWLNIAANFKRSANFPLCLGAIDGKHVRIQNFPNEGSMNFNYKKYHSVVLLAVADFDYKFSFVDVGGYGKDCDSNILKQSCGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVP4</accession>
    <name>A0AAV6TVP4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_012410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000916">
        <property type="protein sequence ID" value="KAG8176157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVP4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="393" mass="44367" checksum="FF8E0D4A4351F1E0" modified="2024-11-27" version="1">MSHRKKNLQITFSFKSQGGDVNVALEGFKSAFLLDIKGLVKKIEETIHKENNKNKVKKLSQLATSDIKQYLYTLVLRCAQEETKYCKNVARVNELEERVASDQDKFDVVAQDLRSLSVIMKANHERIGKFMDGVGAVSDPCNFPTLDHKEEQPVLIIDTNEESGARSYRDALIKKSNVLGKRRVDDIILPKPNRVIIKLKNSEELESFRATLEGDADLNKLANTKISKTRKNRLILFGAPGDITDPEFKNELKDIEGLSDQEIDIFKSFPNNNGSKNYIIDVNNKTKAILLDLSKIIINYNRVKIQNYVQVSRCFKCQKFGHVAFNCRHGVRCGACGGNHDTRSCPNGENEQTFKCVNCIEAKIPDHMHRADSKSCPSFAAHKKLKISQGHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYA4</accession>
    <name>A0AAV6TYA4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_028605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000862">
        <property type="protein sequence ID" value="KAG8176623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYA4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="163"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8176623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="248" mass="28366" checksum="76D31C8F4805CCE6" modified="2024-11-27" version="1">MLGGLNDDELEDAILIGLGEPRESGYLRSSKYSRINLNTFTDVEFQQKFRFRRENFEELCHGLGIPGKIQLRNRYSTTGIEGLAILLRRMAYPNRWCDLESLFGLSSSYLSAISSHVMQIIIEKKGHLLNLGHAAWLNEEKIEVYADAVHHAGAPLKNCWGFIDGTCRAICRPSINQEDFYSGHKRMHCLKYLDKLSPDGMFVCLAGPFLGRRHDSGILRESHLYEDLKRMSTYGDKNFASMETRVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYK9</accession>
    <name>A0AAV6TYK9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000886">
        <property type="protein sequence ID" value="KAG8176405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYK9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="144" mass="16606" checksum="E9B5B73CCA851542" modified="2024-11-27" version="1">MSPYNCIIIKIFDAFTTGPANFASHTYQCTPVPSMSLQSISSLAHEKSLPHTHWGKTSLLCPVWQKFFLKRKPQATFDCAQEKVTQLRFQENYAFVKGFFKDSPAKRNHQRRHSKSSAIYQCSLSLYITNLSANLKRHFRMRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYT9</accession>
    <name>A0AAV6TYT9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase OMA1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Overlapping with the m-AAA protease 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_029304</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000859">
        <property type="protein sequence ID" value="KAG8176657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYT9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="10">
        <location>
            <begin position="208"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8176657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="451" mass="52140" checksum="6948D8436FDA8F6D" modified="2024-11-27" version="1">MLILNFFFRGFPRSVLKLNVQSFKTLNSTLTSNAVGFRTVSKKTPPTINCLFNKTLNPIFKTTISGDKTLLNSRNTQVLAWRCFKTSEQRHFHPIVWIVLKPVFKFAAILTGRGFRKWWRDLPKNKRQYFLNELKANSRKILIILSLVILLSILYYVDHLEETPITKRIRFMAFNDKQLEQINEFELQQIMNQLGEHILPETHYLHQRVEAVVKRILLANTDIEEMKHKKFGIAVIDNSIENAFVLPIGYVFVFTGMLKLCSNDDQLGIILSHEIAHCLQNHGAENVSFSHLLDLISIAIIAAIWAVVPSDSISLLTHWLFQKSVKLLFELPYNRKIETEADKVGLQLAAKACFDVRESSAFWAKMAFLKNTLGDGPEIEFLSTHPSHEKRSEYLDSIMDEAITFRKFCGCPNLSYRDPRNDIETVSKALEMTRSKYFERNTKPEIIITKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYW5</accession>
    <name>A0AAV6TYW5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Alpha-latrotoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">JTE90_017540</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="17">Homotetramer in membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the cationic peptide 01 (latrotoxin) family. 03 (alpha-latrotoxin) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000875">
        <property type="protein sequence ID" value="KAG8176484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYW5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="12" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="15" id="KW-1053">Target membrane</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="22">
        <location>
            <begin position="550"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="719"/>
            <end position="748"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50261"/>
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            <dbReference type="EMBL" id="KAG8176484.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Oedothorax gibbosus</name>
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            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000794">
        <property type="protein sequence ID" value="KAG8177257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
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</entry>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19498" checksum="591973BFC707662F" modified="2024-11-27" version="1">MDTNQWLWRDGNDGRFENDGHYFPKNCGPWREFNENDTCGTDGSPDGNRNLNYKPGNYNPNFVNRNFTPTFRNANYNPAFRNGNYNPSFRNGNFNPCFGNRNCNPPRVRNANYNPAFRNGNFNPSFRNANCNPLLQRDDLGSTFEQAVISNSNPLFLNADYLELEGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAV6U106_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_010777</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
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            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000804">
        <property type="protein sequence ID" value="KAG8177204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U106"/>
    <dbReference type="Proteomes" id="UP000827092">
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    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004995">
        <property type="term" value="F:tachykinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15390">
        <property type="entry name" value="7tmA_TACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001681">
        <property type="entry name" value="Neurokn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="122"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8177204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="394" mass="45064" checksum="6DC4BC281D3CE0E0" modified="2024-11-27" version="1">MGNSQKKEVDLLEMYMDSEKQISNYNSSVCDEIHRRVYGNLTTEESVVTVIQDKFSNYSLTTDKSVDIVIQDKFSSYSDLFAKCFNSTIPSNILYQPYILPWYQQLLWTLLFAVMILVAIVGNTIVMWIIVAHRRMRTVTNLFLLNLAVADFLLASGNAIFNFVFMLNSHWPFGETFCVVSNFVANLTVSTSVFTILAMSLDRFVAVTRPLRPRMTKTTAYSIILSVWTLSSLLSAPSVLYATTITYKYADETQRTLCLLVWPDGMGTGLGKSDLDHVYNIVFLIVTYVIPMTCMGVTYTWIGCILGASKVIGENSDPQNHVIKSKQRVVHMLVAIMLLFAFCWLPYHVYFLFTYYNADVIHAHFIQHLYLAIYWLAMSNSCYNPIVYYVMNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U270</accession>
    <name>A0AAV6U270_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_017463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000717">
        <property type="protein sequence ID" value="KAG8178116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U270"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043540703" evidence="2">
        <location>
            <begin position="24"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8178116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="234" mass="26452" checksum="258D43456D06104E" modified="2024-11-27" version="1">MAFPLPKSAHVVIFLSLITCALAALSSNTTSTDKIKIGQKIPAPVLHRVLPNHASTLSKQMMDTPSLVEMIMFGLAGIPVYKAVGMLLPFFTGRRQHQKNSGRVLQRRQKRDLAYAQQLLDLLVTVEVALEKYGITEPQCQLRATCEIYRKNANGKKNVFEGNFIKLVNEMRREIENPKVVPLAKYVFEYYEEAAIRGETKCNCKEIYSRCPKSLSQFYKKAKGKKQPQRGNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4Y2</accession>
    <name>A0AAV6U4Y2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000661">
        <property type="protein sequence ID" value="KAG8178898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4Y2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="208" mass="23718" checksum="DCBCA62F27EF4F39" modified="2024-11-27" version="1">MMMNGTNAVYGCPPVQHHMSHSSPEYDTKLFYPSTDQQHHSYGYQPDPAEPATGHLPPHQIINESNGLSYTNLDTSAGQSSSGHQHYRHHYSSSNYYNQTLEYDIHPDNNIAYHHHHHPGGYYHHHHQAMSRTSRTTMYQDSSAAGYQGGFAEHHSVQQECVQQMNGGAVVAPYQRPVQQQPVPTYKWMQIKRSLPKQPGEYSNYLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U606</accession>
    <name>A0AAV6U606_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BACK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000641">
        <property type="protein sequence ID" value="KAG8179263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U606"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22667">
        <property type="entry name" value="AT01380P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22667:SF0">
        <property type="entry name" value="AT01380P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACK" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="213" mass="24443" checksum="ED3960A8E5208677" modified="2024-11-27" version="1">MDIYRKTLVKLLAERFEDLIQESDFFEFDLHQIKELLSEDQIGTRSEVVVFLAALKWLNHDIHNRPIHSSDVMKCVRFLAMTLPEVLACLDPPIMNLIRFEPQVKEQLAKALLYISAKSVDMETYFSQFRPRPRQLLLKKNLSFSGASVSMTSKLTPTTQVPNDQLNDVKVGFNSVMSKRMSSTQVPSDQLIAIHSVSTHCGLPRYVQLSFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U738</accession>
    <name>A0AAV6U738_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_027203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000623">
        <property type="protein sequence ID" value="KAG8179491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U738"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000080">
        <property type="entry name" value="RNA-binding protein 39 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="209"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="306"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8179491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="558" mass="62719" checksum="6133E113015854C9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8K8</accession>
    <name>A0AAV6U8K8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_017703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000578">
        <property type="protein sequence ID" value="KAG8180188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8K8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000459">
        <property type="entry name" value="ARM repeat superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="806"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="844"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="890"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1120"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1121"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1139"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8180188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1227" mass="135238" checksum="C34CCEC4B6F63A02" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9Y0</accession>
    <name>A0AAV6U9Y0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RCK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_013940</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000540">
        <property type="protein sequence ID" value="KAG8180934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9Y0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005228">
        <property type="term" value="F:intracellular sodium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000011">
        <property type="entry name" value="Potassium channel subfamily T member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000034">
        <property type="entry name" value="Potassium channel subfamily T member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000137">
        <property type="entry name" value="Slowpoke 2, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="14">
        <location>
            <begin position="314"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="14">
        <location>
            <begin position="733"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="579"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1079"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1081"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8180934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1121" mass="127402" checksum="7F3B9565D3105FC4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAB1</accession>
    <name>A0AAV6UAB1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_018227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000559">
        <property type="protein sequence ID" value="KAG8180609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAB1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="139"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8180609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="519" mass="59178" checksum="56A5F6108160A4DB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAF1</accession>
    <name>A0AAV6UAF1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEHE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_005932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000547">
        <property type="protein sequence ID" value="KAG8180848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAF1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072487">
        <property type="term" value="C:MSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026711">
        <property type="entry name" value="Msl-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029332">
        <property type="entry name" value="PEHE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21656:SF2">
        <property type="entry name" value="MALE-SPECIFIC LETHAL 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21656">
        <property type="entry name" value="MALE-SPECIFIC LETHAL-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15275">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01300">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52052">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEHE" evidence="2">
        <location>
            <begin position="220"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8180848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="358" mass="41042" checksum="8D2D48C48D57384C" modified="2024-11-27" version="1">MRHRRRLSSSSRSVSAVGSSGALCDHLYATTCENLVAENMQLREMVVSHLDMIGQLQEELATKTRQAPCPLLDANDHKLTARVVRSGARDRRMCLVRCQERTAPVLATRYFGRKSKTIPNRALKRRYMGPPKPVPSSRALPPAVKEEVEIPPSCLLHRERGVSKRASHNLRRACKKEEASPQPEQEDYLTTDKEYFPSPAESSSLPAPVEEAPSSDPTPHINVPLWKVKPVTSFYQMEGTENINDIVFERRHQKYELDERRRKRWDLQRLREQRARTERRRRKKEKKEPTSFYPDPQSVEFIEVTDKLPVIAFGHPIPVLEPSDFSLPWIPEAKKKGRRGRPRPRSPEGGRGPCSPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBE7</accession>
    <name>A0AAV6UBE7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000513">
        <property type="protein sequence ID" value="KAG8181489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBE7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17190" checksum="EDAB54ACB117170A" modified="2024-11-27" version="1">MLPANNFKPSLLSHACVCISRVLCTLNFLSSAQRPIAERGAKTCPEFAMSPGACWYGTINDCHQRHKVSLIVEKGKLPNLPAMPIVVVGLIVRTIKELWNVETDVARPPGNESSHGGFDDSTCVDNLRFSLYPRNLLIGVCRKCRNTWPRGFHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBN5</accession>
    <name>A0AAV6UBN5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_000058</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000487">
        <property type="protein sequence ID" value="KAG8181947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBN5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000090">
        <property type="entry name" value="two pore potassium channel protein sup-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF291">
        <property type="entry name" value="IP11374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038061">
        <property type="entry name" value="K_channel_subfamily_K_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="6 12" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="61"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="167"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8181947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="372" mass="41546" checksum="25C621C5E4477B71" modified="2024-11-27" version="1">MKKQNVRTLSLIVCTFTYLLVGAAIFDALESDNEDKQKEALTYVENLLMTKYNISQEDYRIWTTIVIKSVPHKSGIQWKFAGAFYFATTVLTTIGYGHSTPATWGGKTFCMFYALAGIPLGLVMFQSIGERLNTFVAYLLKHGKRCLKMRNTEVSETNLICLVSILSTVVMTTGAAAFSKYERWDYFDAFYYCFITLTTIGFGDYVALQKDRALQSKPEYVAFSLVFILFGLSVVSAAMNLLVLRFMTMNTEDERRDEAEAQTAAQEAVRLEGDVITANGSIISGHDPNISSEVDEITSVCSCTCYGHKRTPKNGYFRKSPTSNNRTPLLPMSVLSAEGRVVSDEPQGPNLVQGNSAMYFPYDDIKNKRASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBQ2</accession>
    <name>A0AAV6UBQ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000523">
        <property type="protein sequence ID" value="KAG8181278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBQ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="82" mass="9269" checksum="AA2823D9CC4C083C" modified="2024-11-27" version="1">MVAFPDPKVIVRLEIVRLMDPAPRTKRWVQSCFSGPKGYRILLEIVRPMDPVPKARVGIHGRLSGPKGHRTVRNWATDGPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBU1</accession>
    <name>A0AAV6UBU1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thyroglobulin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_003984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000493">
        <property type="protein sequence ID" value="KAG8181837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBU1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF3">
        <property type="entry name" value="NIDOGEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043921969" description="Thyroglobulin type-1 domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="118"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8181837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="145" mass="16363" checksum="D3DA91375DD4104D" modified="2024-11-27" version="1">MNYLHLLLFVSSCMTVALAKTKCEEHRERELASTMRLKFVPECTEEGGYETLQCFSSDEDKFCMCMSPEGKQIIGPARDIRNCECPVHYYKQFAESKKNSGVYIPSCNEDGTYVKKQCHKAAGVCWCTDEKGNKTSEASRGSIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCE8</accession>
    <name>A0AAV6UCE8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_000048</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000487">
        <property type="protein sequence ID" value="KAG8181937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCE8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="511"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="702"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="714"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8181937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="814" mass="90986" checksum="2EAD0100E2340B4E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEC4</accession>
    <name>A0AAV6UEC4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_023385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000449">
        <property type="protein sequence ID" value="KAG8182745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEC4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8182745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="193" mass="22369" checksum="26DA9CB0712D94D4" modified="2024-11-27" version="1">MNIFKRHCCTVCSYSAVHKDWLDIHYSLTHKHLCCICGEIFTTEENLDIHFRLHTGTSFTCILCKKRFPTFLRLPTSLICVREIHAAVSYEGNGMNLAYSNSSIRSTGAFHSVDSYKRTELNSLYDNRPTNVSQTFQKPIFHCPVCGKSSNRKDNLTAHMKLHAEPQYSCSKCNKKFHRKDRLKLHMVFKCKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEX6</accession>
    <name>A0AAV6UEX6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_002083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000460">
        <property type="protein sequence ID" value="KAG8182549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEX6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="484"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8182549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="56385" checksum="56B89EAC259A277F" modified="2024-11-27" version="1">MIAADDPLHRKRVVSHMVLLMMCFSCLFVLSAQRINVSITIVHMVNWTALDETSECRPLSFDSNCTVYTDNEPGKLAWSHLIQSQVLASYFYGLALGHWSSECLAAYLKVKWMALFGTLVASTCNFLTPLAATNNVYILIGLQFTKALGQAIVIPSFGMLVDAWVGSDSMAGFMGYCATALPLGAFITILVSGMICDSDNYGWEYVFYISGSIGIIWCLLWSYLASEYFYPTVLIYNTREDPVYNPERPRAPLRFMFTSKAVWAFLLCSLTTYWAWSFNLLLLPLYARRVFQAPMQWNYMASSAPNLLQAFLFLVAVMSSEQLVSNGILNAGPVRIFLMVIGFLVFATCNVLLTFAKCSRGYAALLNFLAYGFIGLNLAATSALPSDLSPNYGGVISATVNTVGPLFGSLLPLAVAFLPDTKEGIGNWNYIFYASALIGFVAMIIFIMIGPRKMEPWNDHQRSDLMELARNGFSDLVDRGHSSEININEKETPSEENSASASAVTDSKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF15</accession>
    <name>A0AAV6UF15_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2</fullName>
            <ecNumber evidence="1">2.1.1.296</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_028182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67024"/>
            <dbReference type="Rhea" id="RHEA-COMP:17169"/>
            <dbReference type="Rhea" id="RHEA-COMP:17170"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167612"/>
            <dbReference type="ChEBI" id="CHEBI:167614"/>
            <dbReference type="EC" id="2.1.1.296"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.296" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000467">
        <property type="protein sequence ID" value="KAG8182338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF15"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120550">
        <property type="term" value="F:methyltransferase cap2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025807">
        <property type="entry name" value="Adrift-typ_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050851">
        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF2">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51614">
        <property type="entry name" value="SAM_MT_ADRIFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adrift-type SAM-dependent 2'-O-MTase" evidence="8">
        <location>
            <begin position="86"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8182338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="754" mass="87358" checksum="916514EB025E0346" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF19</accession>
    <name>A0AAV6UF19_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-dopachrome decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_010896</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.84" evidence="9"/>
    <dbReference type="EMBL" id="JAFNEN010000433">
        <property type="protein sequence ID" value="KAG8183072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF19"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033981">
        <property type="term" value="F:D-dopachrome decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF22">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8183072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="112" mass="12648" checksum="FB9C402C24AC0DF6" modified="2024-11-27" version="1">MPLCAFYTNVSDKDIPKDFEVRLSEILAEVLSKPIERITVNVIPDQRMVRGGSSEPTCWMNLWSIAVFNEEKNPAYASKLYPFINESLGICNDRIVLLFHDINASQVAKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFI8</accession>
    <name>A0AAV6UFI8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000461">
        <property type="protein sequence ID" value="KAG8182514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFI8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043361253" description="Glycine-rich protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="10247" checksum="BC0F1F1EF80015D9" modified="2024-11-27" version="1">MKLLILHLSVLVVCALGDLKVKTKARSADLYGLDGLDSSFGLSGGLSDVSVGKDSAGLGYGLGGDSEISALDLGEGYGIGEKSSGLGYGHGGGGGGGGGGHVHHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFP2</accession>
    <name>A0AAV6UFP2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_008607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000482">
        <property type="protein sequence ID" value="KAG8182071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFP2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000493">
        <property type="entry name" value="serine/threonine-protein kinase unc-51 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="516"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8182071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="939" mass="103448" checksum="3C47534ED199AE42" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFW7</accession>
    <name>A0AAV6UFW7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_009991</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Caudal homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000457">
        <property type="protein sequence ID" value="KAG8182628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFW7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009948">
        <property type="term" value="P:anterior/posterior axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000574">
        <property type="entry name" value="Homeobox protein CHOX-CAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047152">
        <property type="entry name" value="Caudal_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24332">
        <property type="entry name" value="HOMEOBOX PROTEIN CDX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24332:SF9">
        <property type="entry name" value="HOMEOTIC PROTEIN CAUDAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="204"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="206"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8182628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="295" mass="33589" checksum="D859936E248F5CD5" modified="2024-11-27" version="1">MIPSYDMFSPTVRHQLSAYGLSQNYGHQTAYSQYAADNINFNSCGGPAMVESGPANGTYQQNLHNSFSLYAFNNPSHHRQHVVVEDWALPQTTSSPCSYQTQSSGIQFPDNVHPFQVPSPADYSSPGHMRVQEKLEPGLEHPSSDSVVAVSSDGMSGSESPNNLQAGHVQATSGLFRPQPARSPYEWIRRSSCQQTQPNPGRTRTKDKYRVVYSDSQRLELEKEFHYSRYITIRRKVELATSLELSERQIKIWFQNRRAKERRQSKKREELLQKSKDSQIVYQQANLNLANLNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFX8</accession>
    <name>A0AAV6UFX8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000419">
        <property type="protein sequence ID" value="KAG8183375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFX8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="104" mass="12140" checksum="2E43AD9DE7231E05" modified="2024-11-27" version="1">MKEESLISRRRIYDTIASKGVIEQVSISKEMLKYARNARATYAEAADVRRREQHEKVTIVKRKREAALQMKSLKAKTKILQEAEKQRSAIEEEIVALRIQKQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGJ4</accession>
    <name>A0AAV6UGJ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_023394</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000449">
        <property type="protein sequence ID" value="KAG8182756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGJ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8182756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="432" mass="47520" checksum="3AA96EF5C1464484" modified="2024-11-27" version="1">MVTPTQSPRFVENLNVSKQSCPVNPQDLDTTRDEEIIGEFDWSPATQGYVISASFLGYVFTQIPGGMLAEAFGAKYIIAFGLFISSVCHFTSPFVSRIHSNLMIFIQLLRGMGQGFLPVAHCVVAANWFPRSERGLLNTIAMSGYAVGALVGGIATGAICSAEALGGWPSSYYIFEILRLPTLLECVKKRQPTPWDQILCSVPVHALVISLFPHFWIASYTMSVHPVFLGTILHFRIEENGVFSSVPFVIQGASALFSSWTSNWLQKKNYVGVNRLRKGFSFLSYIGYFFTCMGMYAAGCNKWLSVGFNMLQAVPMGLAVGGSMIVAMDMTPRYGGSLMGLTNTIGSIGGFILPMVVGELTNNNQTLEQWNKVFCISGAISLGAGVLFCVFGSGDIQPWNFETIEKYEDYKANFENKKKDNLKNDNDIICHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIH3</accession>
    <name>A0AAV6UIH3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000383">
        <property type="protein sequence ID" value="KAG8184215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIH3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="9164" checksum="C1E33F4D0EC3E31A" modified="2024-11-27" version="1">MDKCTEELPLTFRADITPLKEATTINMQNRDVTVPETGHPSPDDVTNSLNIKKPDNRVSGVVHKFQAPVATTPRNLLCPDLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJG6</accession>
    <name>A0AAV6UJG6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_001672</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000405">
        <property type="protein sequence ID" value="KAG8183776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJG6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043372457" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8183776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7958" checksum="A665F19D51D2156C" modified="2024-11-27" version="1">MLSIVVALFAVCWLPFQTYNVLQQLVPKINEYKYINVIWFCAHWLAMSNSCYNPFIYAIYNAVENKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULJ1</accession>
    <name>A0AAV6ULJ1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_026349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000373">
        <property type="protein sequence ID" value="KAG8184430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULJ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043910826" evidence="8">
        <location>
            <begin position="25"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="6">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="6">
        <location>
            <begin position="157"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8184430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="435" mass="48697" checksum="CA49917E39C6EC76" modified="2024-11-27" version="1">MSKLRLSVCFCVFIFTLLSCHGHADDEDGTAFLLYCDHDIRNFSLALPHRDSAVITRIPVRPRVIDYHVKKKLLFWTDYGDNINKAPLWEARARPSVLRDLSGSFGLAVDWLHDLLYWTDRKDKQVKVAMLDGTLATTVLKEEGIEPFAVVLNPAEGTMFWSDHGTIRKIERCNMDGSDRKVIVKDDIHMPESLAIDLGSRRIFWVDTHIDKNYLSSSKFDGNRRRNLLTGLKRPISVDVYGHYVYFVTFDSGHQAVYQASKEDGSGIKKVLDGEIKLRSLKIFDPSKQSEGFNVCGNNNGGCSHLCLPTSAHTFSCACPNTLLKRSDNITCMDSNGFPVTTPRSTTYSTSTHLPVKDFQINVSSSTEENENQNSDATGASSGTHATLAIIMASLALIAMVGMLLYFRMFLLKNVAITDMANPVYNKNAEENLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULM0</accession>
    <name>A0AAV6ULM0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000341">
        <property type="protein sequence ID" value="KAG8185302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULM0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="244" mass="28225" checksum="511FE16F2683711F" modified="2024-11-27" version="1">MDRIKDLVRLAKLNKLVKEKNYQQEWEEAGYQRSITEFHKPVTTQLKAGEEQLKKNYKAINNLSAIEYPSFETAIMDSKMKSDSESDEEKKSKKNSYTIDPDVDLDTKFLTKYKLPLPSQIFNKPDEIKEVLDKTENISKRLGNLKSQITRGADTAYTKSELNEDLAKIRQYKEKLKALDVTNLFKITGSGLISELEVLTNKLISGSKNKKMYNKIVSILDLLLKDGDLTNDEVKEYYDKFLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UN05</accession>
    <name>A0AAV6UN05_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_014584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000347">
        <property type="protein sequence ID" value="KAG8185109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UN05"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005918">
        <property type="term" value="C:septate junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035151">
        <property type="term" value="P:regulation of tube size, open tracheal system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019991">
        <property type="term" value="P:septate junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284:SF6">
        <property type="entry name" value="SINUOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8185109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="220" mass="25117" checksum="5C700D11BC4E9DB2" modified="2024-11-27" version="1">MARWKASSVRIAANGLAAFCFAFIFIAFVTPYWLNSDRRYYGAVFLRMGLWETCFRSFHDPSDLALRKYYAGCRWILTDEYQKLRGFIEQPFFIAVQVFFTIGFTALLVSCILILAVHLCISSERQKIFVMTIAGLTMVAAICCSLAIIVFGVHGDGRDWMPDPDHNYLSWSFALGVVGSFFTYIASILFFIEASRAKKREEEAMNHRAAYGMEQTHTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNC1</accession>
    <name>A0AAV6UNC1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Retinoblastoma-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_000760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the retinoblastoma protein (RB) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000325">
        <property type="protein sequence ID" value="KAG8185779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNC1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035189">
        <property type="term" value="C:Rb-E2F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048667">
        <property type="term" value="P:cell morphogenesis involved in neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002720">
        <property type="entry name" value="RB_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002719">
        <property type="entry name" value="RB_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028309">
        <property type="entry name" value="RB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024599">
        <property type="entry name" value="RB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742:SF36">
        <property type="entry name" value="RETINOBLASTOMA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742">
        <property type="entry name" value="RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11934">
        <property type="entry name" value="DUF3452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01858">
        <property type="entry name" value="RB_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01857">
        <property type="entry name" value="RB_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01367">
        <property type="entry name" value="DUF3452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01368">
        <property type="entry name" value="RB_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Retinoblastoma-associated protein N-terminal" evidence="8">
        <location>
            <begin position="97"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Retinoblastoma-associated protein A-box" evidence="9">
        <location>
            <begin position="348"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8185779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="857" mass="96958" checksum="67D63ACEAB069986" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPD4</accession>
    <name>A0AAV6UPD4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_022708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000311">
        <property type="protein sequence ID" value="KAG8186117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPD4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043966950" evidence="2">
        <location>
            <begin position="20"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8186117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="220" mass="25823" checksum="4004031E84630697" modified="2024-11-27" version="1">MNKILCLWIFCVGISQVLAQKKYLIYKTDDGYDVSPKTHQNYVHKAQPYKFGYNIKDAKGNSQYHKEVSDEHNYRTGSYGYTDAYGIYRHVDYVADHEGFRAKVRTNEPGTANSHPADVYMHAEQPPHHLQELYHEPIKAAYSYPQKDQHYQQQNQHYGNAGQHYQQKDQHYQQEEVAQEQLYHDQKPVYEEYIPNVKEKVSIVPVYVPQGNVKSSGYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQC5</accession>
    <name>A0AAV6UQC5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000299">
        <property type="protein sequence ID" value="KAG8186492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQC5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8282" checksum="870858E28E797EDC" modified="2024-11-27" version="1">MRLKGLREVRPTGAEKCVVSVPMTPVGQVTCVTIRNEPLKEATEEGVSLGKKASDQEFDAPITQQMSLSLFDYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UR64</accession>
    <name>A0AAV6UR64_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000288">
        <property type="protein sequence ID" value="KAG8186807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UR64"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="9938" checksum="B3582B2CCF0023E8" modified="2024-11-27" version="1">MAFVGQAPPILRIKKQEKNWNKSLVLSGCLSVQLSSDKCPSIRTLCAESGEATSPTSGLLMHKWSTRLVFERKNRLFVPRSEFTTWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6US71</accession>
    <name>A0AAV6US71_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000296">
        <property type="protein sequence ID" value="KAG8186609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6US71"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="9176" checksum="113760F8D33B5C5E" modified="2024-11-27" version="1">MSTWNIVIDQGLASSWHVTMDTKMSGPFDIFVSLFVSEHQSRRKLQILGARVKKKKRGCRNPLKTPGDTRWSQVKNDDGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USI0</accession>
    <name>A0AAV6USI0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000272">
        <property type="protein sequence ID" value="KAG8187440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USI0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11217" checksum="8239BF8C10FF0D55" modified="2024-11-27" version="1">MESGNATFPEVSWFNNGTFNCDSYLPYQRSPFFNGLGCLATVIIALSSIFRSMALIIGFFWDETLRFQMDDRLIIYLSCTTTLHVTLVFYAVSTVCSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTE1</accession>
    <name>A0AAV6UTE1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">nicotinamidase</fullName>
            <ecNumber evidence="7">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_019955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="JAFNEN010000269">
        <property type="protein sequence ID" value="KAG8187525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTE1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8187525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="335" mass="38028" checksum="68A3F015095456D8" modified="2024-11-27" version="1">MRLPRHMAEQDFSKETTFTECFRLFDEDDKQYLNKDDLGKLVKCVIKHDTLPDEFTIDELFACFDKNSDGKIDEEEFNIVWNDWIIPLTQPVTALIIVDVQNDFIDGSLAMKNCPAKQDGNEIVPIINNLLESVNFDIVVYSIDCHPEDHISFFENVNIRKLSDTNEQSLEDIKLYDTVTFEGPPEVTQKLWPIHCVKDTFGCQLHPDLKVVENSIFVNKGQNPTIDSYSAFWDNNKISQTELHSELQRRKVTHVFVCGLALDYCVAYTALDAVEFGYATVLVEDAARGTDIDNIEAMKNKLVSNLCVVASSTEAINLANGDDIQLEFAKVLALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTF9</accession>
    <name>A0AAV6UTF9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_019228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000281">
        <property type="protein sequence ID" value="KAG8187018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTF9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF27">
        <property type="entry name" value="PIN2_TERF1-INTERACTING TELOMERASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8187018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="281" mass="31963" checksum="768025384606D5FD" modified="2024-11-27" version="1">MISTIILRLTMCATVKTFSIGHFDLNPRGNLWANDEGGVGRRLLQRMGWREGRGLGRGEDGPTSPLRPTIVRGNAGLGFTEKLPFVKESHAYDSVLENLNKKFQTNRESKQTEERGLEQRSQQFKKRLHYRKFVRGKDVGRYSPRDMAAIFATRPHDPPADAPTREEECQSTFRSPLSMEEYFARKMQKKSGEDGEIKKSVLEEDGEDGEAVLEEDAPSKMPSNEEGCLSLPPGRRYDAWLESQRAAARMKVYRAMVRRLCTHPVLRTTNLARLKGYGNWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTG5</accession>
    <name>A0AAV6UTG5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_027028</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000265">
        <property type="protein sequence ID" value="KAG8187617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTG5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF285">
        <property type="entry name" value="V-MOS MOLONEY MURINE SARCOMA VIRAL ONCO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="140"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8187617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="389" mass="43816" checksum="40745C78EA809A2F" modified="2024-11-27" version="1">MEPVVTISPSTAPSYHNQTSPSIKSADTTPKLPRRERLASFSRLIASESFTEFREKSSKDVPRHKRKVGSLRRLDVESPTIQISPSSPVKNETLNLPANGYFDSYQLPFSPTLLNAKSPKYFSPSYRKPTPTKSPLYKSDQRSQYLGRGSFGNVTLCLYKGSQFALKATRHKSYVGERNFLGLRHPHLVSVLQVTQVQEQVLICMEFAGHCNLQQVLDTRSELDFPRRVSFCLQILSGLRFCHQHNIVHADVKPANVIVSPHGICKLGDFGHSILATSDDVPLEDVVGTVAYAAPEVLRGARPTPEADVYSYGICLWQVESRELPFAGEHPHVIIYKVAHYGARPIFFSSGNRFMDTYIEVAKLCWHAEPMKRLTAHQAYEMLQEITRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU94</accession>
    <name>A0AAV6UU94_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SMG9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_025822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000259">
        <property type="protein sequence ID" value="KAG8187784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU94"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039177">
        <property type="entry name" value="SMG9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8187784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="50084" checksum="5A6CEDFEDCAD6165" modified="2024-11-27" version="1">MAPPIKLKDTGSELEASPSKPLVILAKPPDKNKPKEGHTSVNVLANPSVPNELLKSPTIVQKNPVTVETDDAGHSGNKDESFSDLVKNVAQRVFHVQQKPAVVVNEGEQKLSSPPEMSYPVKLVDESLQWCDNALEYLHDATDFYVIGVLGLQGVGKSTIMSIISGIHSERSKWQLFKPQTNDLKEIGEHCTSGIDMYVSSQRIILLDTQPVMSASVMDHMIQYEKKPPGGPDYHSVENALLMQSLQQAAFLMAVCHTIISVQDWFIDLNYLRFLLSAEMLKPTTPINMHEQIPEETSEYYPHIVFVQNHSQREDFDPESISKMQETLHLTLQKSKLKFSGSVNFDANRSYAKDSSKKVNLFLIPDKEPPQDFDSQNDQFPEYKGHPGYQYLAETLSQQVLSMPRSLLTHTALSEKNWFHYSARIWETVKKSTLFLEYNRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUN6</accession>
    <name>A0AAV6UUN6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_019954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000269">
        <property type="protein sequence ID" value="KAG8187524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUN6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8187524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33861" checksum="6BDC2B1359126D92" modified="2024-11-27" version="1">MKDIMYRLKIDRKEHFIWKLLVIISYLFFYKSKEVAVNKMSEGEPNQHAPPRQGFQAAVDHMTSNKIDSLLWLTRLGTIVFTALSMIPLFGFNPQTSYQRALMSNAATSALRLHQRMPRVQFTREYGAMLMMEDSCHYLLYSILFIISYPITLSLLPVFLFALLHSASYSLLILDKLGHSSGSASDFMRWVAGPRQRSILRLVSFTEVTLMPITVLWLFSGKGSLLTAFSYFRFLTFRYASRRNPYTRNVFHEMRIAIEAFANEPGRMPVLKNLCHKMINYTSYLAPPIPAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWS5</accession>
    <name>A0AAV6UWS5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000261">
        <property type="protein sequence ID" value="KAG8187756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWS5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7578" checksum="2F7AD0F46FA8A789" modified="2024-11-27" version="1">MIILSSGNQGIGQAGDFTQIIGGGGHWSTPTSYVNGSSCIEWLWERVEASANDWLISWKRLLNGHRLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXZ2</accession>
    <name>A0AAV6UXZ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_007179</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="JAFNEN010000236">
        <property type="protein sequence ID" value="KAG8188573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXZ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000050">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF59">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="13"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8188573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="467" mass="51859" checksum="8146D60A5FE50149" modified="2024-11-27" version="1">MSFGEMEVLNQTLDASDPELLGIIQKEKHRQCRGLEMIASENFTSRSVLQALSSCLHNKYSEGYPGQRYYGGNEYIDEVERLCQQRALETYSLSSDKWGVNVQPYSGSPANFAVYTAVVEPHGRIMGLDLPDGGHLTHGYFTEKKKISATSMFFESMPYKLNPETGLINYDQLETLASLFKPKLIIAGISCYPRDLDYKRFREIADQNGAYLMADMAHVSGLVAAKLAPSPFEYCDIVTTTTHKTLRGPRAGIIFYRKGVRRVTKAGEEKYDIEDKINQSVFPGLQGGPHNNSIAGIATALKQAQSADFKKYQQQVKANAKRLAKELTDKGYSIVTGGTDNHIVWLDLRPTGINGSRAEKVLEDISIACNKNTVPGDKSALNPGGVRLGTPALTTRGFVETDMVKVAEFIHNGLQLALDVKSKSGPLLKDFKSKLAEDPEFQQRVKELRNNVENFASQFPLPGYEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V082</accession>
    <name>A0AAV6V082_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-protein ligase E3B</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">HECT-type ubiquitin transferase E3B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_018685</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000200">
        <property type="protein sequence ID" value="KAG8189904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V082"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000012">
        <property type="entry name" value="Ubiquitin-protein ligase E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF3">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="11">
        <location>
            <begin position="675"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8189904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1040" mass="118916" checksum="BCF19896DBBB5789" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1P9</accession>
    <name>A0AAV6V1P9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRP15-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_009086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000199">
        <property type="protein sequence ID" value="KAG8189947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1P9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8189947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="246" mass="28226" checksum="FE19866AAB633E3E" modified="2024-11-27" version="1">MYDSEESNKESEAESEVESHSVEGAEENEKDSSFRKKKRARYDDDVSMSEEEEAGNMAWADALSKVLHSSDRILSKAKKDADIKPKAAPEIEVVDESGQVVSEDKTKEPKSKTQTLLKSKKEMLDRMNKKSEWELMGRVKPDIRNKEKERELVKIATRGVVYLFNTVEKHQKSKKDPKSNPKKDKKLGAIKGNFMDILKDYAKKDKVELDPVVKKTKEEETWSILKDDFMMGAGMKDWDKESDVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1R9</accession>
    <name>A0AAV6V1R9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sodium channel protein Nach</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_008473</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000213">
        <property type="protein sequence ID" value="KAG8189511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1R9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF300">
        <property type="entry name" value="PICKPOCKET PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1000"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8189511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1043" mass="119757" checksum="59E6D39FD33421D3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V351</accession>
    <name>A0AAV6V351_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_023053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000195">
        <property type="protein sequence ID" value="KAG8190081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V351"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_eL18/eL18-A/B/_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="7">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8190081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="188" mass="21408" checksum="5B013DF327A5FB1D" modified="2024-11-27" version="1">MGIDINHKYDRKVVRKSPKSEDIYLRLLVKLYRFLARRTGTKFNKVILKRLFMSRINRPPISLAKLIGFVKKPGNENKTAVVIGTITDDIRLLQVPKMTVCALRVTERARARILKAGGTILTLDQLALQAPRGKNTLLVQGQRTAREACKHFGRAPGVPHSHSKPYVRSKGRKFERARGRRKSRGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3B5</accession>
    <name>A0AAV6V3B5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000162">
        <property type="protein sequence ID" value="KAG8191262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3B5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9671" checksum="31F8DE176D7BC739" modified="2024-11-27" version="1">MIIITLPSISNLECQFASFTRVDSFRRRPEAIRNNSPSQLSKMSVLSGNRADLPAKGGGAASRRLEQVQFKAAVWPVWNGFAEIHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V467</accession>
    <name>A0AAV6V467_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000158">
        <property type="protein sequence ID" value="KAG8191500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V467"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="106" mass="12047" checksum="8B4F7AB04395903C" modified="2024-11-27" version="1">MELDVIENPCMELREDCVACYLRQGMLLWVMAGGSRLLSQLKSYAALQHVLCGHILSFNAWKKGPWKRSVRGTAGVRKASKHWAFRGWPMKDPGFHLSAFMQSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V490</accession>
    <name>A0AAV6V490_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000173">
        <property type="protein sequence ID" value="KAG8190823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V490"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043338922" evidence="1">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8201" checksum="B19C96BAA884B40D" modified="2024-11-27" version="1">MKAIFLVCLLVVLVAVVHQTRATVDCSDPNSVRMQCGTACPAACGKKRPSICTAVCVCVLVKIRGGEHCWPSDAIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4M4</accession>
    <name>A0AAV6V4M4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">28S ribosomal protein S22, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000173">
        <property type="protein sequence ID" value="KAG8190843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4M4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019374">
        <property type="entry name" value="Ribosomal_mS22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13071">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13071:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10245">
        <property type="entry name" value="MRP-S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="38655" checksum="7C9A6DD8D62C455E" modified="2024-11-27" version="1">MKSISIFNAVLRRYICSNKCFYASSNCYSTEGSSKIKAETLFIKPEVQNILTKITGLDLGKVFAPRNSQLKPHQYEFVTEERLKELQEKAKAKAFTKLQMPPVMSIREPIDEILSKDPELQGYLKEKTVFTDISTNITNRDRIITVREVDGTLRKANWEERERMIQIFFPLPGRSLEVPKLFESPNLERLLDSHEYIFVLDSACAQFEPDAPDYHRVTAATYEHIRRMGMFNVVRSTRHFGPMAFYFALRKEIDDLLVDMIKHNLISDASDTVKLLYIVNPELKTSSSADSNDIDIIQNYIKNASTKKGGLELALQTFFEQLQTKESQEAGMTEAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5U9</accession>
    <name>A0AAV6V5U9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_006056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5U9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF99">
        <property type="entry name" value="RASGEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="49"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8191304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="282" mass="32836" checksum="B0B34BACABF55F74" modified="2024-11-27" version="1">MKFVRKLFKKSKVSKKEDSIIESFPKDRGDGQAIVNKPVQIYGDLIDLEPSKIAKIIAQKDWETFKHIKQEDLPEYQRRWLYPQDLPNRSNDSEVLKKMAQNYTEVYYWTLEAIIQGQTPNERAKVLKKLLQVAQELLKANDLNATHAIVAALTVPAVELLDKTWKKVSTKNKKMRSNMEKLFRAKNNYARLSTYMQQQMREHKIVIPVMTLVVRDFKVVQPPCPDISTMTLKRTAVFRAVLKLLKEANHAETSICKETLHYWDSLHVTQAKVDDISFHLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6L6</accession>
    <name>A0AAV6V6L6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_029092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000140">
        <property type="protein sequence ID" value="KAG8192359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6L6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="14"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="722"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8192359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="752" mass="83592" checksum="A7FB563DEC306C89" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8V9</accession>
    <name>A0AAV6V8V9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metalloendopeptidase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_025307</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Zinc metalloprotease. Provoques deadhesion of endothelial cells from cell cultures, and also degradation of fibronectin, fibrinogen and gelatin in vitro. Its role in the venom is not fully understood but it might act as a spreading factor that facilitates diffusion of other venom toxins. Alternatively, it might be involved in the proteolytic processing of other venom toxins or it might play a role in extra-oral digestion of prey.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="JAFNEN010000146">
        <property type="protein sequence ID" value="KAG8192041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8V9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="14">
        <location>
            <begin position="44"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8192041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="241" mass="27670" checksum="2CDA4867931D287E" modified="2024-11-27" version="1">MLIEIEKFNASDYSVNENNTYVDPIEASGQFEGDIVLSKIQQRNAIRNEDLKWPGGVVPYTMPLFFGVQGRIMVALAVSEFSRNTCVRFVTRTNQTDYLALFRGGGCYSMVGRMGGKQELSLATDCDQMGIVIHEFMHALGFWHEQSRIDRDQYVRIRWENISPGTENNFQKYSAYIQQTLDEEYDYSSVLHYSGRAFSKNGRATVEPKQFMGNFVIGQRLGFSRTDIKKINKLYNCTGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V994</accession>
    <name>A0AAV6V994_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_002125</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000141">
        <property type="protein sequence ID" value="KAG8192303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V994"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000267">
        <property type="entry name" value="Zinc finger and BTB domain-containing 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8192303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="368" mass="41897" checksum="9C19A58D77A21F34" modified="2024-11-27" version="1">MSDCCQVPTGDLLDNLITHECVPCKKCVECHHCLRATGYLREAFMKPRSIQKFMDTEEEIDDVLDAVLAHQGGAEPPRYILVGPKNEIVETFPRTKKTLKISPTSDEEVESDTPVTDAVQKLVQGFPSSKLTVQQNLKLLSSKLTRPQNVSIGIEPISSKDGQTTSSVAICIETDSDSEDNVVENPVIHRTIFRCDKCEKTFTNEKDLTIHSVYHSVEDGHTCDICGASFKYSYELIKHNLQHTEKNASWVCKLCKKIFRNALEHTVHMGMHNNEKPFACDICGKRFDGNFKLQRHFRTHTDIYPFQCEKCSKKCRTMAQLRTHNMIHDGVMNYTCAVCERQFRHHCNLKTHLLRHHKVSDASDASDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCW1</accession>
    <name>A0AAV6VCW1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="14" type="ORF">JTE90_011437</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000113">
        <property type="protein sequence ID" value="KAG8193877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCW1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF40">
        <property type="entry name" value="INNEXIN SHAKING-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8193877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="380" mass="44248" checksum="79B9734070E7FAB9" modified="2024-11-27" version="1">MFSVLESVSNLPKGQKCKIDGAVFQLHYTVTVVALIAFFAILTTRQFVGDPVNCIYSSEKIKQEAMDVYCWTHTTYTVPFWPNNSETGHPGVGQDHDPSTFRYHTYYQWVYFVLLLQAALFYAPRFLWLEWEGGRVSTLMEGLRVAALRREEKEDKVEVVLDYLLTTWSKHDWYARRYLICQGLTIVNVLAQYLLLGLFFEENFITLGFRQLHYHFQTAKETSPLYKLFPLVTMCSFKAFGETGETQTTPAICIMPLNIVNKKIYLILWFWFLILIVLSLINIGLDISLHFRSNFRGYALRSKFQFVNTDVVQLLCAKGGVGDWLLLYLLGRNLDFIVFKEVMEKLNVHFVEGDGRNLDDREHESSNEKRKKSFRSFFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VD87</accession>
    <name>A0AAV6VD87_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_003604</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000111">
        <property type="protein sequence ID" value="KAG8194003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VD87"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042609">
        <property type="term" value="F:CD4 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033691">
        <property type="term" value="F:sialic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050859">
        <property type="term" value="P:negative regulation of B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46958">
        <property type="entry name" value="B-CELL RECEPTOR CD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46958:SF1">
        <property type="entry name" value="B-CELL RECEPTOR CD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="915"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="123"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="232"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="338"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="437"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="526"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="613"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="730"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="815"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="970"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1200"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1200"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8194003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1243" mass="136436" checksum="682F069C56C70F3C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDN5</accession>
    <name>A0AAV6VDN5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000115">
        <property type="protein sequence ID" value="KAG8193766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDN5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="137" mass="16021" checksum="FAFBF6DE239BDD07" modified="2024-11-27" version="1">MEENFDGKKPEELFREVFLKCQKLRISKEELSKLPSVKKLKPKKNLNKKIRSAFYLFSAVFVLVSFLFSVGFPPVSKFFAKIWFGIHGYDPESEMCVLNMPGDLQNLFMPPFDCSICRNLTKIERVTNISPEEFEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFL5</accession>
    <name>A0AAV6VFL5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_017261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000098">
        <property type="protein sequence ID" value="KAG8194822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000742">
        <property type="entry name" value="NFX1-type zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="8">
        <location>
            <begin position="1967"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8194822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2052" mass="234079" checksum="C334F26FFC47A9E5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFU1</accession>
    <name>A0AAV6VFU1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium-activated chloride channel N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_013260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013642">
        <property type="entry name" value="CLCA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041940">
        <property type="entry name" value="choice_anch_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08434">
        <property type="entry name" value="CLCA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="888"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1175"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium-activated chloride channel N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium-activated chloride channel N-terminal" evidence="3">
        <location>
            <begin position="189"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8194508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1306" mass="146390" checksum="BEC6D4BC59387975" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHK5</accession>
    <name>A0AAV6VHK5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_023330</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAFNEN010000092">
        <property type="protein sequence ID" value="KAG8195153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHK5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000004">
        <property type="entry name" value="Glycoprotein 3-alpha-L-fucosyltransferase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="107"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="242"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8195153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="434" mass="51218" checksum="2581E4315B16568A" modified="2024-11-27" version="1">MFNRKCDKLKLMMFKSCRTLKKNKILFGSVFLCILFVTYFICIFIETPDPNNEIVINVNASYPSDILGTHEPLPDRLLNKKLTFDHVYESRMVGFPPDLKTFVPAQEVKIILMWTKWNHLWNTINYYSLQNGRKQFVDCPNSNCVVTNRRKYLSKASAVVFHLLDTKYEDLPPERNHRQRWIVYNMEPPWLITRHHPSDLYRFDNLFNWTMGYREDSDIPARYGFTTKSRYPQSRYYDGVFKNKKRNVVWLASDCGTDSRREDYVKELQKYIDVDVYGSCGNYTCYPSQSISCYNTLFKRYKFYLSFENAICKDYVTEKFFNVFNSDIIPVVFGAADYSKYAPEGSVVHAGKYPQPQKMAEKLLEIASKEKLFIGILKKKSAFRAYLDPWPCRLCNKLHSSKSLSVLKNVEKWHIDDAQCKKWDIDSKTYTEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJ79</accession>
    <name>A0AAV6VJ79_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_006564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000066">
        <property type="protein sequence ID" value="KAG8196654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJ79"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043574443" description="Chitin-binding type-2 domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="41"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="118"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="181"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8196654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="658" mass="73697" checksum="D554BCA783352459" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJA9</accession>
    <name>A0AAV6VJA9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Solute carrier family 12 member 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_004775</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000078">
        <property type="protein sequence ID" value="KAG8195768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJA9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000030">
        <property type="entry name" value="solute carrier family 12 member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12 MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0868">Chloride</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="596"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="15">
        <location>
            <begin position="84"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="469"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="509"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8195768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="698" mass="77116" checksum="DA4FDE88FC6723E2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJE1</accession>
    <name>A0AAV6VJE1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000075">
        <property type="protein sequence ID" value="KAG8196029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJE1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="171" mass="19439" checksum="74B92A75009A2E6A" modified="2024-11-27" version="1">MDIRRFLKCDGESLPKRPRMETCSINSSPSPSNHDLTSLPPSETPTSSNKTSEISCASRDLGKYLGKISRIDDLLKYHLLTDPWVPGDDYKFPTSSHMKRGREEKRRANIGHLKTYNWLVFSDEKKGLLCKYCCLFAHQKLVGGQKTVPIQKLIIEPLRKFAKLIGKDGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJW9</accession>
    <name>A0AAV6VJW9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000059">
        <property type="protein sequence ID" value="KAG8197112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJW9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="153" mass="17305" checksum="E9BE0EB22A83D0C2" modified="2024-11-27" version="1">MSVDYVATCSFMWINKKCLPSKIAFVSVHEPSVVFTVEPDPSTCYFSMQDVLLNMSLPANPFDVKKEPGEAFVVPVWDMERYISRDFHTKYLERQDIWEKGIVGCLDIATYNYLFPLLPLGTVKYLGNTNVSPTLEAQHAAQVLSNNNSGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJZ2</accession>
    <name>A0AAV6VJZ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mesencephalic astrocyte-derived neurotrophic factor homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">MANF/CDNF-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_001160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARMET family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000076">
        <property type="protein sequence ID" value="KAG8195926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJZ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.225.10:FF:000003">
        <property type="entry name" value="Mesencephalic astrocyte-derived neurotrophic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045333">
        <property type="entry name" value="ARMET-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045332">
        <property type="entry name" value="ARMET_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12990">
        <property type="entry name" value="ARMET-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12990:SF5">
        <property type="entry name" value="MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20145">
        <property type="entry name" value="ARMET_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043966962" description="Mesencephalic astrocyte-derived neurotrophic factor homolog" evidence="8">
        <location>
            <begin position="17"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="ARMET N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8195926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="14295" checksum="05C32509E18A81D5" modified="2024-11-27" version="1">MIATTFITILLFKLQGDKINCLESKSKKCEVCVEVLTKFAQSLRRSELNDSERIEERFVKFCRKSTGPENRFCYYIGGTSDSATRVLSEMSKPLSWGLPVDKICQRLGSKDLQVCDLRYKEPADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKQ6</accession>
    <name>A0AAV6VKQ6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000059">
        <property type="protein sequence ID" value="KAG8197050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKQ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="107" mass="12202" checksum="4192085891BED5B3" modified="2024-11-27" version="1">MLEFFILVSVRGPTSISRTLSLSDMHQRSTTIKNFYNAVYVEYFQCCLLSLVFSILGITIGLFSVIGMSRGFFVWASVRLAPFNRYFSKLRTYDIELKASPTLPALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKR7</accession>
    <name>A0AAV6VKR7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Solute carrier family 25 member 51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_012310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000069">
        <property type="protein sequence ID" value="KAG8196494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKR7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052465">
        <property type="entry name" value="Mito_NAD+_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131">
        <property type="entry name" value="SD08549P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131:SF1">
        <property type="entry name" value="SD08549P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="112"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="207"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8196494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34533" checksum="49E4BC55DB897682" modified="2024-11-27" version="1">MAISSSDMTKSIPHKLPPDGTDHMVKVEEFVCGWGSAFINIIITFPINKVMFRQMLHGVNSQHAFRQIHREGMQFLYRGCLPPLLQKTTSVSLMFGIFNTNKSYLDHNFPNTFYITKLCLSGVASGASEAILTPFERVQTLLQDKHYNSKYRNTYHAFQELRTNFGIKEYFRGFTPILIRNSIGNIFFFGLKDPVNDLFPPMESLSGKLFSNFMSGAFVGALTSTIFYPVNVVKTKMQVCCGTPFLSITEGFRLIFNERGRSIRRLYLGVHVNYSRAFLSWGIINASNELLKKMFFNEGNNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNH6</accession>
    <name>A0AAV6VNH6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000045">
        <property type="protein sequence ID" value="KAG8198025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNH6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="8062" checksum="FC68D651E161FFC5" modified="2024-11-27" version="1">MEPTSRKLEFEMTLNDFMMLGALVGRPSRMDPILLREQLPAELGCQRWRRGFSLATQDGDLELPKGLRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRH7</accession>
    <name>A0AAV6VRH7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000044">
        <property type="protein sequence ID" value="KAG8198116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRH7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="96" mass="10770" checksum="812A16F0F530A69B" modified="2024-11-27" version="1">MTQTVPAVPLLHLYYQKGLASDSKQELYNPPLPKRPCGPDHGINPLQATSCSHGNPNTLQFRKRAFISNCWCGLFSILGQEEEWVGYLRASLWLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRP9</accession>
    <name>A0AAV6VRP9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000035">
        <property type="protein sequence ID" value="KAG8198830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRP9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8170" checksum="AF16275201F52A95" modified="2024-11-27" version="1">MQVEGKPRFMSTRAHFGPPKSSHDRITLLSSCEDRRDSSSASFVSSLRSEGTGEDGRPETGTPQRHLLVIEVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSA2</accession>
    <name>A0AAV6VSA2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_021604</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSA2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030865">
        <property type="term" value="P:cortical cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21505">
        <property type="entry name" value="PPP2R3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000091">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.220:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039865">
        <property type="entry name" value="PPP2R3C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8198356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="441" mass="51989" checksum="7C5D391B84FD7214" modified="2024-11-27" version="1">MLLNVYCRMNVEYEAWQLYENWTDCSSSSSTKISSFEKTSSVSSTSLLPPFYYKVPFEEGSLQQKLREEARAVFIERKNKELLDNEDLKKLWMLLEQNLSPPFVMEDHMINYTDFKKVSSKSDEKFRPYFSARIFAKLLQNDKVGRISIRHFFNYVMRKVWLHQTRIGLSFYDIAGQGFLREMELENYIMELIPTLPQLDGLESSFHSFYVCTAVRKFFFFLDPLRTNKVKIQDILACSFLDDLLELRDETLPKDVQEANWFSAPSALRVYGQYLNLDTDHNGMLSKEELFRYGTGTLTPIFIERVFQECLTYDREMDYKTYLDFVLAMENRKDPQALQYFFRLLDIEQKNFLSVFDLNYFFRAIQDQMKAHGQEPVLFEDVKDEVFDMIKPADPFKVTLQDLIQCGQGDTIVSILIDLNGFWTYENREVLVADSSDEAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSK3</accession>
    <name>A0AAV6VSK3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_007101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000035">
        <property type="protein sequence ID" value="KAG8198797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSK3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF68">
        <property type="entry name" value="GH19763P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043989353" evidence="3">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8198797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11672" checksum="3C8B285728E22E95" modified="2024-11-27" version="1">MWKAAIVLLTAAVLKDIHAQHTPYISRPCLGLGCRTLLPMDPVLPVSPEKVKLDVYYETNCPDSMRFITRQLYPVYLEMKDAIDIQLVPFGKASETYDTVSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VU11</accession>
    <name>A0AAV6VU11_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Schwannomin interacting protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_009367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VU11"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035332">
        <property type="term" value="P:positive regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039045">
        <property type="entry name" value="SCHIP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015649">
        <property type="entry name" value="SCHIP_1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13103:SF2">
        <property type="entry name" value="IQCJ-SCHIP1 READTHROUGH TRANSCRIPT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13103">
        <property type="entry name" value="SCHWANNOMIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10148">
        <property type="entry name" value="SCHIP-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Schwannomin interacting protein 1 C-terminal" evidence="3">
        <location>
            <begin position="615"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="778"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="782"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8199523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="820" mass="92017" checksum="C51C5A8C2BDA005B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZ59</accession>
    <name>A0AAV6VZ59_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000008">
        <property type="protein sequence ID" value="KAG8201137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZ59"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="108" mass="11987" checksum="0AFB37A71C6456C1" modified="2024-11-27" version="1">MNRSFFPIPRTPKKERRILRKKSLSECAEDGEDSPGGIPDWRSLGQHLPHQSLSVRGRLPERIGAHNYSLESPVSRRSTRHSFTAALFKLDAGLPGIGGDEGTPSIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZY7</accession>
    <name>A0AAV6VZY7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Extracellular superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Superoxide dismutase copper chaperone</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_012739</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZY7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000004">
        <property type="entry name" value="Copper chaperone for superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000759">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HMA" evidence="17">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8201673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="368" mass="40084" checksum="D52F986FD1030A32" modified="2024-11-27" version="1">MQNSESESSTVSSKVEFDVNLTCQKCASKVEDALSSISGVSTINIDVEKQSVIVQTSLPSQVIKEAIQSTGKRAVLKGIGSASAVAELKHSSGLLGVIRFHQTEKECIIDGTIDGLTPGKHGLHIHEYGDLSDGDESIGPHFNPDNSAHGGQQDCKRHYGDLGNINADSSGRASFRILDKIVQVPDIIGRSVAVTENRDDLGQTNTGTSSTDGNSGKSLASAIIARSAGLFQNPKRLCQCDGTSIWDETKQPSSSFFKKRYYYFVYKHTVAAAIITVSYIDTPTLTRSLTPNDFGQSWNMAPTTLATLKRPFQCTHCGKGFTQKANLQRHMLIHTGHFPFQCTICTKGFRQKVNLLQHMRTHGYFKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TD88</accession>
    <name>A0AAV6TD88_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006872">
        <property type="protein sequence ID" value="KAG8155733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TD88"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="255" mass="28326" checksum="FDFB3F4C8DF4EAB8" modified="2024-11-27" version="1">MGRKKPGRKTEEKVCVHRNLREPACKRGERGRDFSHAGGQGGRPLKESARQGSVELLHHNVGAAEVVAAKNAQASTNPWTQQPNPWSSPAPSAGPSSWQGASESGSAGNQCMQSQQLTQLEPIDLSWKGANKSGSAGTSQPIGYWLSQSDNVREDCKKIHEVFEEAYEKIVSGSSLSEKEEELFKALLYAFNLNNQILECHQTNFIVKNGKIASLIDDSVNVKEYLQKVIDKTKEEYRVNKEEAYDLNEFLFFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDC9</accession>
    <name>A0AAV6TDC9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regulator of rDNA transcription protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_002512</name>
        <name evidence="3" type="ORF">JTE90_006718</name>
        <name evidence="2" type="ORF">JTE90_007576</name>
        <name evidence="6" type="ORF">JTE90_013153</name>
        <name evidence="1" type="ORF">JTE90_015704</name>
        <name evidence="4" type="ORF">JTE90_022598</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006453">
        <property type="protein sequence ID" value="KAG8155925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010006345">
        <property type="protein sequence ID" value="KAG8156068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010005052">
        <property type="protein sequence ID" value="KAG8170673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010003204">
        <property type="protein sequence ID" value="KAG8172048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010002786">
        <property type="protein sequence ID" value="KAG8172376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010001509">
        <property type="protein sequence ID" value="KAG8173759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDC9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8155925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8156068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8170673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8172048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8172376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8173759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="14983" checksum="E26A9D9A821BB9BF" modified="2024-11-27" version="1">MIGRADIKGSKSNVAMNAWLPRASYPCGNSSDTSCIKLVKSKGSIGPAFAVRIHTENQDQASFCPFALREVSVLAELALGHLRYHLTDVPPQPNNPPESVLGADRALQGGSALGARSVILTGRFPLNRVSKETMKAVVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TG98</accession>
    <name>A0AAV6TG98_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005295">
        <property type="protein sequence ID" value="KAG8170521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TG98"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7601" checksum="15FEA0D734A8B8BB" modified="2024-11-27" version="1" fragment="single">EKPKRKAEAQRIGGFMRVARPKIEVAHEASDETDDSQRYSPLPSANNKEGTHRGTITLRLSIAMLLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIU9</accession>
    <name>A0AAV6TIU9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003620">
        <property type="protein sequence ID" value="KAG8171722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIU9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00005">
        <property type="entry name" value="Antisense to 23S rRNA"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11593" checksum="4A1F300AE4FFD279" modified="2024-11-27" version="1">MVLRTTGPLPKAMNQVSRTSVPLVLNRITIATTVIIGLKQNLSREGPKPSSRSLWGVNKSNAWRILLRNDRKSRHRRIKKQRRLNLGCHEPVIPGVTLLTPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIY3</accession>
    <name>A0AAV6TIY3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003904">
        <property type="protein sequence ID" value="KAG8171491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIY3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="171" mass="18809" checksum="5AD6C28361FC3995" modified="2024-11-27" version="1">MVASHHWPLDQAHEPSVRTCGSSRTEQDYYRNDESSSVFILKIKIKRAFALLLYARFLSSLSSPWGHLRYHLTDVPPQPNNPPESVLGADRALQGGSALGARSVILTGRFPLNRVSKENDESSGISLTVQAPPTYTTPLMSLHKLRLVSSSTGSSFPLIFQVRSLGCGFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJF4</accession>
    <name>A0AAV6TJF4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003508">
        <property type="protein sequence ID" value="KAG8171818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJF4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="133" mass="14637" checksum="774DABC3831D9FB9" modified="2024-11-27" version="1">MEVFYYPKRPGCRGDVLLFKNHQVSWAEVLSGFLSFGPALEDLSTEALPGTTSGQAILECRKAGPNCHSLLVTNLSGDSPRDAMSAGLSWLGTKCQWSLLVVSRILDVLLLMNGFHLRGEEDNYVQTTFESVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKX0</accession>
    <name>A0AAV6TKX0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002816">
        <property type="protein sequence ID" value="KAG8172328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKX0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="151" mass="17166" checksum="DAE68A7E4D3F33B0" modified="2024-11-27" version="1">MRGQKPSRASGAGTLRGPDDGVYEKAFDAYPKVKRQLDEKGKQFLKEWQEEGKLKGRQDDYKENVLIYLIARNKKKTPYKEKTCPFEGLGKGKKGKPSQKRLFGKRESRNWGQVQLLKGQEAEYPPTGKGEISISRLELLGEQQKAARATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKX6</accession>
    <name>A0AAV6TKX6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_018147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002690">
        <property type="protein sequence ID" value="KAG8172450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1340"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8172450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2088" mass="219856" checksum="271107BD72848E91" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TM62</accession>
    <name>A0AAV6TM62_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002483">
        <property type="protein sequence ID" value="KAG8172664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TM62"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="7718" checksum="B2824C3B97D45792" modified="2024-11-27" version="1">MFRRLGSPVVETLSEDEDDPYGETSVKPSAIRANLFGSPSSARDTRQPQEALLVPSRPPCGRRPAGQPLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TN02</accession>
    <name>A0AAV6TN02_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynein heavy chain tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002179">
        <property type="protein sequence ID" value="KAG8172983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TN02"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="2">
        <location>
            <begin position="3"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8172983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="287" mass="33365" checksum="397926FC4EFF3576" modified="2024-11-27" version="1" fragment="single">ALQALHNIFNTSLRFFVEDQERLSTMENRIFGMTALIQYSEFDIFDRESKPDWDRIVFVFMRDVSTFEDELKVYLGSLFKESLSWDNAYILARSFDEEDVSPSIKEFIDNSRTDMLKQFINEILKTENKFLAQESNPPLLEGIPASTSAILWAKNLLLNISRPMSKIFENDTMSKKDLEVQERFKKTEQLLLSYKNAKYDSWKVEAAEKLNQFLQTSVLLKQSISTDNLTGITKLEASVSYVVNFPIYLEEVGIEARILEHLGYEIPSFVANVVLQEKTFIRQRKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPA6</accession>
    <name>A0AAV6TPA6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_009169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PC-esterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001512">
        <property type="protein sequence ID" value="KAG8173734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPA6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14469:SF0">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14469">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8173734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="264" mass="30217" checksum="0A2993C5D8C04FAB" modified="2024-11-27" version="1">MRAVYKDFLCLMTDDRIIPDVNLRAKLEYSVFGDKLLSRGHKNNARVFREERRSTQWGVDAFFFFITQVYNDYIEEVLKRIKRGVRPDILIVNSFLWDVTRWGADGVNVYKKNLTKLMNRLRSRLPNTLVIWMTTPPISKNIKGGFLLPDLEFLKYSLRFHVLEGNNFASEVVIEHGFDVVDAHYYLQHQIHRRADDGVHWKPDAVRFILNLLLSHISVAFNVPLPPHGPPQFSADEAQESGDEAAAASTRAGDEAVASTSGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQH8</accession>
    <name>A0AAV6TQH8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_000698</name>
        <name evidence="21" type="ORF">JTE90_001239</name>
        <name evidence="2" type="ORF">JTE90_001709</name>
        <name evidence="16" type="ORF">JTE90_002437</name>
        <name evidence="6" type="ORF">JTE90_002608</name>
        <name evidence="5" type="ORF">JTE90_006324</name>
        <name evidence="17" type="ORF">JTE90_007070</name>
        <name evidence="13" type="ORF">JTE90_009854</name>
        <name evidence="8" type="ORF">JTE90_012439</name>
        <name evidence="4" type="ORF">JTE90_012842</name>
        <name evidence="9" type="ORF">JTE90_015632</name>
        <name evidence="10" type="ORF">JTE90_015633</name>
        <name evidence="7" type="ORF">JTE90_016071</name>
        <name evidence="20" type="ORF">JTE90_017513</name>
        <name evidence="18" type="ORF">JTE90_017743</name>
        <name evidence="11" type="ORF">JTE90_019909</name>
        <name evidence="14" type="ORF">JTE90_022852</name>
        <name evidence="15" type="ORF">JTE90_022853</name>
        <name evidence="12" type="ORF">JTE90_024505</name>
        <name evidence="3" type="ORF">JTE90_024628</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006448">
        <property type="protein sequence ID" value="KAG8155927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010006427">
        <property type="protein sequence ID" value="KAG8155967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010006366">
        <property type="protein sequence ID" value="KAG8156050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010006352">
        <property type="protein sequence ID" value="KAG8156059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010006286">
        <property type="protein sequence ID" value="KAG8156139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010006221">
        <property type="protein sequence ID" value="KAG8156188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010006167">
        <property type="protein sequence ID" value="KAG8156224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010005931">
        <property type="protein sequence ID" value="KAG8158368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010005931">
        <property type="protein sequence ID" value="KAG8158369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010005393">
        <property type="protein sequence ID" value="KAG8170469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010004879">
        <property type="protein sequence ID" value="KAG8170794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010004735">
        <property type="protein sequence ID" value="KAG8170872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010003900">
        <property type="protein sequence ID" value="KAG8171498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010003900">
        <property type="protein sequence ID" value="KAG8171499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010003871">
        <property type="protein sequence ID" value="KAG8171530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010003327">
        <property type="protein sequence ID" value="KAG8171962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010003189">
        <property type="protein sequence ID" value="KAG8172056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010002966">
        <property type="protein sequence ID" value="KAG8172211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010002510">
        <property type="protein sequence ID" value="KAG8172638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010001545">
        <property type="protein sequence ID" value="KAG8173686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQH8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8155967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8156050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8156059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8156139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8156188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8156224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8158368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8158369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8170469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8170794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8170872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8171498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8171499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8171530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8171962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8172056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8172211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8172638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8173686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13849" checksum="7CF6267B4E036DC3" modified="2024-11-27" version="1">MFLRFRKKPFHHRGTPTIKGPLYLILPQKYCHKIKYETTSHSRQTVLDSPRPALHIAAGRGNNKGRKGRQASRVGHAHGIQLTPTRSPMLRSQYAPYSHRNNFRDGAARHGGRTTRREAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TR78</accession>
    <name>A0AAV6TR78_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001233">
        <property type="protein sequence ID" value="KAG8174379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TR78"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043809439" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14874" checksum="CF31F4F03895E077" modified="2024-11-27" version="1">MYQLSTGKASLLLLLIWVATVKALAIGTQSFRISEEEFFNCTVYLGCIHPLETGKETRIREAYELCGPKNKIMCMETFLEISRLPMPNNEDVFWNKTIREICATKTEVEGKKNFNEQAQEIATWWSVSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRJ8</accession>
    <name>A0AAV6TRJ8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001203">
        <property type="protein sequence ID" value="KAG8174487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRJ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="132" mass="14548" checksum="6648C5F336A39110" modified="2024-11-27" version="1">MENIHRTSSKKLCENCPTSPLSASKRLNGGFATRWVTCHKQESQPNYSLLPPNLKQHTATLINTKSECNSNHNFHPISNNTQQLLTTLSQRAINSPQLFTTQSQSANLHAATLHNTKSECAISCSTARSETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TS77</accession>
    <name>A0AAV6TS77_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposable element P transposase-like RNase H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001216">
        <property type="protein sequence ID" value="KAG8174448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TS77"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="1">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="259" mass="29243" checksum="DB89C6B00E4D29DE" modified="2024-11-27" version="1">MMVRHIIDTGNEGIVLLGNEVIKNGDYFVNPCQSGDLSMNSIVAISSDSPDAEVLPIEKKRNAKRPARYSSDKAILLSEEEESQSIISSKRYPLPKLPCSYKKLPKKIMSKSRAISHGYYHQSALYAEPTVQSIEKEDARLNATQSAFSVLFNEDQQLALQRKNVNNGSFWSDETVKTAMGLRFSCGSKSYEHLLRLNFPYPSIRTLQRRLENFKFESGILEEAVEFLKVKVAGFADVEKQCVLLLDEMSITESVEFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TT21</accession>
    <name>A0AAV6TT21_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_000808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010001084">
        <property type="protein sequence ID" value="KAG8175060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TT21"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8175060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="9490" checksum="6A225C1E1CDC1206" modified="2024-11-27" version="1" fragment="single">VLLDKKKELEKQYPGDSTIPRPKHWGGYLLTPETFEFWCGRSDRNHDRLRFRRKNPSEVLDEKKTHIGENGWVYEYLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTN5</accession>
    <name>A0AAV6TTN5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RuvB-like helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010001137">
        <property type="protein sequence ID" value="KAG8174800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTN5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TIP49 P-loop" evidence="2">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8174800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="130" mass="13706" checksum="C28603F66E3B9299" modified="2024-11-27" version="1" fragment="single">MFADTAVKVQEVRDVTRIERIGAHSHIRGLGLDDSLDPRAVSQGMVGQIAARRGAGVILEMIKEAKIAGRAVLIAGQPGTGKTAIAMAMAQALGTDTPFTVISGSEIFSLEMSKTEALTQAFRKSIGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTY7</accession>
    <name>A0AAV6TTY7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_021114</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001007">
        <property type="protein sequence ID" value="KAG8175417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTY7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF265">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR DM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="40"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8175417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="508" mass="57709" checksum="6FFEE127960DCEE8" modified="2024-11-27" version="1">MSPLNCTSPSLNETSPSYTILETSLIATITTILSLVTIIGNVLVMVSFNMDKRLQTVNNYFLLSLAVADFLIGLFSMPIFTTYTLMEGWTLGPIVCDLWLSLDYLCSNASVLNLLMISFDRYFSVSSPLKYKARRSGRLAAFMIACAWILSFLTWPPWILAWPYIEGQRSIPDNRCYIQFLETNSYITIITALVAFYVPVIVMCVLYFKIWVLTEKRKEFLSEMLRENELSSQQAESVVKRTRRHRVKEFFISFCNVDCDEGPDEENISPGTTPTSVDTPVVGSRATSVTIRPEQIAYLDNLISKGKVDDNKDSIYTVLIHLPERRNSETELLPSVTMIQGELPKLPAPMRSSLSTSALIANSTVMSPPMARSNSNEVLSASRLNTKQVRMQRPNLKKKKEVGCKKPIDRKAARTLSAILLAFIITWTPYNVLVMIKGVETFFSCDDHIPMVLWNFSYYLCYINSMVNPICYALANVNFRKTYWRILTCTWRKQSKLSIIRGLHSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTZ5</accession>
    <name>A0AAV6TTZ5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001108">
        <property type="protein sequence ID" value="KAG8174939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTZ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="153" mass="16505" checksum="C3130A5474E9AEF5" modified="2024-11-27" version="1">MNKAYKKNKTLRKRVLALGKKSLKNGAVRTTKQDDYEATALALDHSTATGHPAAEEAVREITPDDAGRELPRAKKWSQARSWHPGPFGGPLPSVRLPLGHSASATLAVPHVSTAPDRVKLQQHLQQRVRLEGGSRAAISALLVPPGQGFREGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TV32</accession>
    <name>A0AAV6TV32_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001034">
        <property type="protein sequence ID" value="KAG8175306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TV32"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="202" mass="22982" checksum="C11B9811B06D4814" modified="2024-11-27" version="1">MLACEESCKKHVFEEVDETELEKELEEIEAYIDRARVFKKKLEKLTLEQISKYNPVLDESSPVSDFLQGEVEAEERIELASCSLTQHKSRDPGRGYSRATYNLEKERGSQSDRVKELPSATDLFAAAQVPKKCIFCSLPHPSADCLKAGKMKLKEREELVQQSRCCFLCLKPNHTVNKCFMKTSCLCCGKKHNILLCSGRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVB7</accession>
    <name>A0AAV6TVB7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_006694</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001024">
        <property type="protein sequence ID" value="KAG8175352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVB7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8175352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="392" mass="45412" checksum="35663DC89518BCD0" modified="2024-11-27" version="1">MFPKFLKIAFIPNPYLVIVQKNENNKTEITGGYEGRILKDIAQAIGFDYELFERQDGQYGWRDNETGQWTGMLGMLDRGEVDFILEKFAYDYDIFNHFSVIPFSCYRFAYATNKPTFESAESRFEMPFQAEVWMASVVVYLLVTVVLWILLLKTKLYTKEKAGETLLDRRSKRRTNRKPRHQISQLGKLFRPERYNRRFQQIRRLDVPKHANNRISFSDVVMATIKILFKQNSTSRYLKSASTKAVLITWMIGSMVLCYSYSGSLLSFMTLPSLSKPIETVEQLANAVDRHGYKLHVVQKEVVPLIIESNPFLADAAVKIIKNDWILDYAGNTKFLQMLEQDNLLELVCVNNNKLIDVDGYPVLERRNCVVLDDVTYHSVGLPLEKLLGKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVY9</accession>
    <name>A0AAV6TVY9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_014079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000917">
        <property type="protein sequence ID" value="KAG8176125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVY9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8176125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="8365" checksum="F1F05B692FBE2FB4" modified="2024-11-27" version="1">MPRQIMEIKEFLLTARRKDAKSVKIKKNRDNVKFKVRCSRFLYTFVITDREKAEKLKQSLPPGLQVKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWL7</accession>
    <name>A0AAV6TWL7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_020163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000888">
        <property type="protein sequence ID" value="KAG8176377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWL7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23701">
        <property type="entry name" value="At1g26750"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059242">
        <property type="entry name" value="mS23_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023611">
        <property type="entry name" value="mS23_dom_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019520">
        <property type="entry name" value="Ribosomal_mS23_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15925">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15925:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10484">
        <property type="entry name" value="MRP-S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS23 conserved" evidence="7">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8176377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="148" mass="17028" checksum="DBD90BFA3E552B75" modified="2024-11-27" version="1">MAGSRLQRIGSIFERLSGILKAGAIKEQDKPIWYEVYKAFPPKHEPAFTRPPVDKEIKPIYYPEDIIRAKFLKLYGSTGVYNLLHPGEKSVMQRFVEKYQEMEKSNKYSNEEEIFKATESALQVDGITFVRRMASSPTDDSKEETKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWP6</accession>
    <name>A0AAV6TWP6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000921">
        <property type="protein sequence ID" value="KAG8176038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWP6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10470" checksum="35204D6C8D8FF1D5" modified="2024-11-27" version="1">MSPAVKFLNDITSGGTLSPNALKKICRGVLWFPLHYRFDTSSTSCCVMQSGFLQGVEKMIDPLCTVSFLSHKVQRNTRGMLKVLRKLALKREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYB2</accession>
    <name>A0AAV6TYB2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000822">
        <property type="protein sequence ID" value="KAG8177075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYB2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="336" mass="36798" checksum="1FCC166B0CA16CE4" modified="2024-11-27" version="1">MATLLIHWPRHFMPILSGAVLKRLSKTMLKIKGDRGSLCVTPRPGRNGAEFAPIKVSDGRTVTSLLGRKILRDSSTLSGTRPTLTQMVKKFAFTLSGTRFQLLALTPSGHAADAYLILQLATSLMVIGHIRSSPPSTRVTGGKPLKSLSNWTESFITLVQYSNRQPPPQVSFSFYCFSSSPDGLSPSAPMERPRYTSDSLRASLGSHQSSPALSPGRKDSGGHQYRLSACRIHPRAAVNSLIAYLIMKTSGPGRNGGGALKTEEGHKERQDVWSPNPLTRQLRCTKNPPSYELNHSSLGSSHRRAFFAGRLSPELAHRKGDNDDLPPFRKKPHPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U020</accession>
    <name>A0AAV6U020_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000756">
        <property type="protein sequence ID" value="KAG8177742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U020"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24500" checksum="C03EB638B10FB7DA" modified="2024-11-27" version="1">MIFPKFLRVAVVPSAGIFQVNRTNSDKLQVVGGDESAFLELLSKALKFDYELNIPDIGAWSDMVNGTWTGVVGMVHRGYADIAIVDHFSVVKVHLISASRYCCDKSKQQYFIIHFVSARQIDSHVLFYGLLVLLDDTEHGQGIEDVTDLGKRIMLGTYKAVTFAGSSFVYTMKSSGNDYIRATGEAIVQNDWFVLPDKTSVLNVLKNYDTAMKLRQERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0B6</accession>
    <name>A0AAV6U0B6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_015952</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000774">
        <property type="protein sequence ID" value="KAG8177548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0B6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000039">
        <property type="entry name" value="Glucosidase, alpha neutral C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000023">
        <property type="entry name" value="neutral alpha-glucosidase AB isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043552007" description="Glucosidase II subunit alpha" evidence="12">
        <location>
            <begin position="26"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="14">
        <location>
            <begin position="82"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="13">
        <location>
            <begin position="368"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="15">
        <location>
            <begin position="704"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8177548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="926" mass="106391" checksum="45584BE16C7BA86F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0K3</accession>
    <name>A0AAV6U0K3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein SHQ1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_018344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000787">
        <property type="protein sequence ID" value="KAG8177318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0K3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06463">
        <property type="entry name" value="p23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="497"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8177318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="531" mass="60544" checksum="CC3AE31AE77A4E1A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1K5</accession>
    <name>A0AAV6U1K5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ANK_REP_REGION domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_026214</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000779">
        <property type="protein sequence ID" value="KAG8177429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1K5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="8" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="9" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8177429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="75632" checksum="EFB27BC01E0609E0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U275</accession>
    <name>A0AAV6U275_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000684">
        <property type="protein sequence ID" value="KAG8178572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U275"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043338901" evidence="2">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8178572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="177" mass="19826" checksum="231C13CF29481E03" modified="2024-11-27" version="1">MHSITKISILLLTTCICIKAHKYSTPVGKAPAPPTKATPPPSSTNIHKKYVDYDLKSQSSRYGKGDPFYYHHYGPDHKSYEHMYNHYGDHYPYYYGKSHDYHYMIPYVLGGFGLVLLPILTLMLTLAVNIAPASNIPTAVTTATGKLLRSLNSTQIIDEIADKLDSAISKYGRMNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3N6</accession>
    <name>A0AAV6U3N6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000715">
        <property type="protein sequence ID" value="KAG8178130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3N6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="470" mass="52904" checksum="CB0738898EDB2DA6" modified="2024-11-27" version="1">MYHHTDTLSADGTSSFTKRKRDESHNRKRRHRKETRHSKNSKQPSRHSRSDKYKSDTKLKNSHLKNYDSEYIGPNRLTKHMGFLAKGKISDSISRLEELLPENVRARSKQDLRRILELNASTKTNGSGSAISYSRQHKDISSGEESNFEPVSYRSPGKHSAKSSNEKCEEKSGKSSVMKLKKALVSSAESRRSSEKRTPQQNQDEVSICREIITKKLHSTMASTNNLLFPNSSIQTSLLKELTDIKAEYQASQKAVSNSSNCESSQDNINSSLIIRQELMNIKGNYQASQKAVSNSSNCESSQDNINSSIIIRQELMNIKGNYQASQKVVSNSSNCESSQENIYPSCIEDSPGSNFKLNPVLTQDFPSPKKMENLFPVRQDYSSSSESEDEIYVDAQTLLRRQAVIEKTRPKNVDSKAESCSSGRDSSVILIRSSQSSNGSPVWAPKSSPVKFVPKFIPTPKLYFRQKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7F0</accession>
    <name>A0AAV6U7F0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_023359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000581">
        <property type="protein sequence ID" value="KAG8180150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7F0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8180150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="217" mass="24389" checksum="81B0A4C4E8CAF78B" modified="2024-11-27" version="1">MSSKVSKDTLYDCVNAVLEGSLKKQRKFVETVELQIALKNYDPQKDKRFSGTVKLKNIPRPKFTVCVLGDQQHCDEAKANDVECMDAEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRLLGPGLNKAGKFPSLLTHNESMMAKIDEVKATIKFQMKKVLCLAVAVGHVKMTPDELASNLNLSLNFLVSLLKKNWQNIRSLHVKSTMGPSLRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U805</accession>
    <name>A0AAV6U805_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hsp90 co-chaperone Cdc37</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_005799</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000554">
        <property type="protein sequence ID" value="KAG8180702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U805"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000001">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="10">
        <location>
            <begin position="118"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="9">
        <location>
            <begin position="286"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="47"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8180702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="367" mass="43061" checksum="780700E77027C513" modified="2024-11-27" version="1">MVDYSKWKNIEISDDEDDTHPNIDTPSLFRWRHQARVERMAEFQHEKDQVDIKCSETSRKLQDLKEKVEYAKTHEDMNMEELTAELKKLEEEDTKLKKEQEEMLKKEKLMPWNVDTISKEGFTKTVINKQAVAPKMDELSEEEKAERQAKFNKENEKLLKEFGMFQKYDDSKNFLREHPHLACEETANYLVLWCISLEVEEKHQLMEHVAHQCICMQFILELAKHLNVDPRSCISSFFTRIQMADVEYKDAFNAELESFKVRVRDRAKARIQKLIEEAEEEERQQRLGPGGLDPVEVMESLPESLQKCFESKDIELLQQTIAAMPEEEARHHINRCIDSGLWIPDAKKAEREAAEKEAAEKAAANES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U848</accession>
    <name>A0AAV6U848_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_002821</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="EMBL" id="JAFNEN010000603">
        <property type="protein sequence ID" value="KAG8179780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U848"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF27">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 1" evidence="5">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 2" evidence="7">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 1" evidence="5">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 2" evidence="7">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="6">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) (complex) asparagine" evidence="6">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10 12">
        <location>
            <begin position="122"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10 12">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-10"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-11"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8179780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="601" mass="70330" checksum="E261C524B5C68CEE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8M1</accession>
    <name>A0AAV6U8M1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_006738</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000556">
        <property type="protein sequence ID" value="KAG8180682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8M1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20188">
        <property type="entry name" value="T-box_TBX2_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000003">
        <property type="entry name" value="T-box transcription factor TBX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002070">
        <property type="entry name" value="TF_Brachyury"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF181">
        <property type="entry name" value="OPTOMOTOR-BLIND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00938">
        <property type="entry name" value="BRACHYURY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="8">
        <location>
            <begin position="110"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="501"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="532"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8180682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="549" mass="60288" checksum="C4071B13633208F4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9Q4</accession>
    <name>A0AAV6U9Q4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Heparan sulfate 2-O-sulfotransferase pipe</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_020464</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000579">
        <property type="protein sequence ID" value="KAG8180166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9Q4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007734">
        <property type="entry name" value="Heparan_SO4_2-O-STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129:SF15">
        <property type="entry name" value="URONYL 2-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8180166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="39686" checksum="86107ECA9A754AA3" modified="2024-11-27" version="1">MKYHPLLGEELLLNAPRTNKLAPRCVVLVFVAGISFYCVFSVIQVPVNEITSARLESGSTPCPCCDEVDPGRLFYNRVPKCGSTTLITLMRRMAAKNDFVHFNSKVYDRKNADQKEQRRIVMQVKNTPSPCSFDQHVFFINFTKFGESPPVFMNVIRDPVERIISSYFYRRMIARQNRTRLKPGAYWLNKKFEHCVLTPDPECTFMDGHNYSEVQLPYFCGQEPECQLLNDAGALQKAKQNIERYYAVVGTLEHMNVTLQVLEATLPRFFKGAYNVYRNLGVHRNQNPHKEQVKEEIKEILRANLSAEYELYDFVRQRLHNQYRSLVEEPPLDEQTSFLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UA72</accession>
    <name>A0AAV6UA72_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000517">
        <property type="protein sequence ID" value="KAG8181407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UA72"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="121" mass="13571" checksum="30099C60B7C52378" modified="2024-11-27" version="1">MEKQAKDLWTKIKTDCTGGIDDRKIDASQEVKNLRMMDSEIANDYVARAKGLVTKCSSLGLMISSRELMTSWRPYVRKNKRFNEEVDPAQGVSKHLPLQDPRRPAVTALDGGMSGRRATSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UC01</accession>
    <name>A0AAV6UC01_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000507">
        <property type="protein sequence ID" value="KAG8181570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UC01"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="459" mass="51827" checksum="C1D07834502A37D9" modified="2024-11-27" version="1">MDEKLKGLKTQKKVTKSSLTRLKNKLDKDIDDLDLIELNVKRNRLVEINAEIKAIFNGIFEVCDEKEIDEYCEEKEVIMDECETLLVKLDRSLSKFSKTPESNTRPGGRVDVVEIKLPTLSLPTFSGAIDECKNTCRKCGKSHHTLLHFENASGSRTDSSTNPAVDSGNLSVDARVFVPSTQNCSPNSNSEPVNPPVSSFCSDFGPHEQVLLCTALVKVCDSVGGTQLCRALLDPGSQEDVLAEEEDLTLVDDDVKVLGMKWNPRTDLFGFKVTPCEKKKNFSKREILAETSRVFDPIGFISPCVVLMKILLQDVWKQNLAWDQPIPEELNKRWLTFCEEFHLIEQVEIPRCVLQPQDLGTRGLLPSQLIDCEHWFRGPPWLLQPMDEFSTFQTPELVLPETALMEEKKIVASDYTTPVANLSTFIPTSQIGSRDAMVLFQIVEIPILFRTNHLNYHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDA0</accession>
    <name>A0AAV6UDA0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Dicer-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_016563</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000513">
        <property type="protein sequence ID" value="KAG8181475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000628">
        <property type="entry name" value="Endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000005">
        <property type="entry name" value="Putative endoribonuclease dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044441">
        <property type="entry name" value="DICER_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048512">
        <property type="entry name" value="Dicer_platform"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20932">
        <property type="entry name" value="Dicer_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20931">
        <property type="entry name" value="Dicer_platform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="31"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="386"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="16">
        <location>
            <begin position="583"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="20">
        <location>
            <begin position="584"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="17">
        <location>
            <begin position="1119"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="17">
        <location>
            <begin position="1331"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="16">
        <location>
            <begin position="1538"/>
            <end position="1577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8181475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1585" mass="182527" checksum="46616FE08E1417B0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDT9</accession>
    <name>A0AAV6UDT9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_008839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000519">
        <property type="protein sequence ID" value="KAG8181366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000651">
        <property type="entry name" value="RaBConnectin related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="3">
        <location>
            <begin position="1696"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="3203"/>
            <end position="3237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="954"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1380"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1407"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1601"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2170"/>
            <end position="2191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2966"/>
            <end position="2992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="976"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2170"/>
            <end position="2179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2972"/>
            <end position="2988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8181366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="3296" mass="365810" checksum="FE3C00CA6BFCABF9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEI7</accession>
    <name>A0AAV6UEI7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000487">
        <property type="protein sequence ID" value="KAG8181940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEI7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="9267" checksum="055CDC827CFE7660" modified="2024-11-27" version="1">MKLQTRHPQRTCLQNPTGRIKEIVNDQSSAELDQRESITFESNRRRAYMLHAELCLMSVGDIAEWTVVWDIKRAQLHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF70</accession>
    <name>A0AAV6UF70_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_018475</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000456">
        <property type="protein sequence ID" value="KAG8182639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016327">
        <property type="term" value="C:apicolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035332">
        <property type="term" value="P:positive regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090251">
        <property type="term" value="P:protein localization involved in establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000015">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000037">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000080">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000106">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000035">
        <property type="entry name" value="Protocadherin Fat 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000118">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000275">
        <property type="entry name" value="Si:dkey-30k22.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
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            <end position="2755"/>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="3203" mass="352959" checksum="C4962AFE47A8EE8C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHA9</accession>
    <name>A0AAV6UHA9_9ARAC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003323</name>
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        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG8182945.1"/>
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        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8182945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10274" checksum="51CC0CD10E8090E1" modified="2024-11-27" version="1">MSNRWFFRRQTKDQQLQRPMIPAKWQAEGSNCSSNSERSRQRGCLLPRIELTASSPTAGHVPPLSPVKNLGVPSLVMHKADSLDNIGPPIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHG2</accession>
    <name>A0AAV6UHG2_9ARAC</name>
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        <recommendedName>
            <fullName evidence="4">ATP-dependent DNA helicase 2 subunit 1</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_014409</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer of a 70 kDa and a 80 kDa subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ku70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
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        <property type="protein sequence ID" value="KAG8183234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:double-stranded DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000001">
        <property type="entry name" value="X-ray repair cross complementing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000080">
        <property type="entry name" value="X-ray repair-complementing defective repair in Chinese hamster cells 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="18">
        <location>
            <begin position="301"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="17">
        <location>
            <begin position="562"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8183234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="598" mass="68339" checksum="4729BAEDA6AAD3CB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI69</accession>
    <name>A0AAV6UI69_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000403">
        <property type="protein sequence ID" value="KAG8183812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UI69"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="81"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="387" mass="43603" checksum="3456F4148A64D5E3" modified="2024-11-27" version="1">MKNLCSDLLIGHDLLTSHSSLEIEFSGNRAPLKICSLTTAKVPAISLFENLTPDCKPVTTKSRRYTEADQSFIANEVNKLLDEGVIEPSKSPWRAQVFVVKGDNHKPRMVVDYSQTINKYTLLDGYPLPRIDDLINKVSQYKVFSTVDLASAYHQVPILDSDKPYTAFEAAGELYQFTRIPFGVTNGVPAFQRNIDSLIKEEHLEGTFPYLDDVTVCGTDQEEHDQNLKRFLAAAKKYNLTLNTEKCNFSTKCVKILGYLIEDKIIKPDPDRLAPLMNLPIPKDTASLQRTMGMFAHYCKWIPKFSEKIRPLLTKEFPLSEEAVKALNSLKKDVAEASFSAIESDAQFRVETDASEFAIGATLSQAERPIAFFFKNPEHSRTKTLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIB9</accession>
    <name>A0AAV6UIB9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">JTE90_010197</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000385">
        <property type="protein sequence ID" value="KAG8184155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIB9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8184155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="165" mass="18907" checksum="083A7E7894D035EA" modified="2024-11-27" version="1">MNIFLGGHFFFYGHQALQFTGLLEPGFKLFPGVAICEIFTYERGVPQGLTIMCLLPINILNSKIYAFLWFWFVFLFIVSCCALVCRCAFFLSPWFRKASLAYGKRHLDKKQLQAVVSQTSAVDCFLLYLISRNIGSLKFKEVVSRLAKEDLGVEKFSEDDENTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UID4</accession>
    <name>A0AAV6UID4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat-containing protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_006865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000396">
        <property type="protein sequence ID" value="KAG8183940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UID4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057852">
        <property type="entry name" value="Beta-prop_WDR11_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057853">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057854">
        <property type="entry name" value="TPR_WDR11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039694">
        <property type="entry name" value="WDR11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23751">
        <property type="entry name" value="Beta-prop_WDR11_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23752">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23753">
        <property type="entry name" value="TPR_WDR11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDR11 first beta-propeller" evidence="2">
        <location>
            <begin position="31"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="WDR11 second beta-propeller" evidence="3">
        <location>
            <begin position="515"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="WDR11 TPR" evidence="4">
        <location>
            <begin position="914"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8183940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1253" mass="140794" checksum="25BB43A66CD8A878" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKE0</accession>
    <name>A0AAV6UKE0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reelin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_002403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000406">
        <property type="protein sequence ID" value="KAG8183766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKE0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF33">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="3">
        <location>
            <begin position="163"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8183766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="507" mass="56645" checksum="0B64E5B4A1E58228" modified="2024-11-27" version="1">MNSFLVINGILFVAFFEISSAFINGFPKEQCDEMDPTKIKLSGAGSNKGAQEAENATDFTSEDGTPTSVQLSDSLNLYRIVTSSPKYRRGRTMDIINGILFVAFFEISSAFINGFPKEQCDEMDPTKIKLSGAGSNKGAQEAENATDFTSEDGTPTSVQLSDSLNLYRIVTSSPKYRRGRTMDITIRGPDFNAFMLQVRKIGSDERRGVDQIIRVGEFVEWPANLKPVVCDKGLPPTALTNKDYKQKSGVTFKWKAPKEDVGDVQVVARFVAAEEYWQLTESREIPMNEFPVNLKNCGKAKSCILYSENQPSCHEDNCDYILTYSVVNSTSVEFVLGGTSKGDQNYLAVGFSASPEALTMKTIACMRAKTVAEIKYFTFDTIEEGLVEYPLHMDNKKMDLDGDRMWCSFIVPMVTHNEEGHGLDLSVPMYHVYMRGTTNYTKSANYPILPSKLLISKNEIAVDKIKLQYHTMEKPKESSANQIYTTLPVLVIFVFIVDVLQKAKKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UL17</accession>
    <name>A0AAV6UL17_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000354">
        <property type="protein sequence ID" value="KAG8184926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UL17"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF637">
        <property type="entry name" value="EAG-LIKE K[+] CHANNEL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="612" mass="67894" checksum="85C680F733F3D0F5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UM39</accession>
    <name>A0AAV6UM39_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_002770</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000342">
        <property type="protein sequence ID" value="KAG8185245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UM39"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000073">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-9-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="9"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="183"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8185245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="450" mass="51261" checksum="0BD63ACC337EF718" modified="2024-11-27" version="1">MQGINYISDEKNQVLTTNVWLDQEWMDDYLGWNPLEYENLTKIRIPCEKLWLPDIVLYNNADDYTRGYMNSRAMLEPSGNVFWPPPTKLRSTCPVDVTYFPFDDQTCILKMGSWIYDGLQVDVMNRTSEVDLSNYVPNGEWELLEARIVRNVVFYSCCTEPFPDVTVTLVIRRKTLYYMYNVVMPCMMMSVLTLLVFVLPPDSGEKIALGVTVLLAFSVFMLAIAEKMPETSESIPLLGIYLTVVMAITSISVVVTVVVLNFHYRGPSRKEVPQYLRELILQRFASCNCFGSSSKSAARRNYDAGIHVPPSFKGDSFRLTIDSLHEELKDMNPDLTCNESPGAMNIGSDLTTSKRRSHTVPVSKSHVNGASPGSVGSSSTRIQAEILRALQYLLHRQELEDHRVRVVNEWRQIALAFDRILFWIFFVVTVVSSLSFLVIVPLHRRGLKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UM62</accession>
    <name>A0AAV6UM62_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_001506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000360">
        <property type="protein sequence ID" value="KAG8184809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UM62"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003834">
        <property type="term" value="F:beta-carotene 15,15'-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8184809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="533" mass="60143" checksum="3249986CDB69D096" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNS9</accession>
    <name>A0AAV6UNS9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000354">
        <property type="protein sequence ID" value="KAG8184906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNS9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="67379" checksum="D1591A98F33DB31D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPV2</accession>
    <name>A0AAV6UPV2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_018525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000328">
        <property type="protein sequence ID" value="KAG8185648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPV2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="17"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8185648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="989" mass="109823" checksum="D5CDD2E5167AC908" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQJ3</accession>
    <name>A0AAV6UQJ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000299">
        <property type="protein sequence ID" value="KAG8186505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQJ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8258" checksum="E044F761010801BA" modified="2024-11-27" version="1">MDSPQNDPISMNIYVGVPHVLRLALSASDVSCVFVFHIPSPPIKWSNKGIAVWSSGKESEKNGRKLNEIRIECY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UST5</accession>
    <name>A0AAV6UST5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_011685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000274">
        <property type="protein sequence ID" value="KAG8187315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UST5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8187315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="421" mass="48085" checksum="CACCE14C32684BD5" modified="2024-11-27" version="1">MSSFQLGELILTSKPYAYVLSNACRSSRCDFCFKKQKDLKRCSQCSFLFYCDKSCQEKSWDVHKAECKFIKKAKPKEPTASMRLIALILFKIKKLGREFPVEDVYGRKMTFQSLMSHAEDIQKSLKSCQQMMALIGTLIVYIGSTNIPLPSDFVEIFGKMCINTFSICDNEMQSIGSGLYLGASVFDHSCQPDAEVVFDGINLTVRAIKDIPHRNINKIYISYIDQMQLTEDRQNALKEQYYVLCQCQRCLSPHLDELMTKLTDSGRENQVSEFNAQLEHIKQMKKDKVGPSTIYNACLNQLALHEVALADTHLCKVKTLEIAFDICIESNQWADAITLGKQLLKPYRLYYGQYHPTLGIHLFKLGKIQALQNLPSASTTLQEAENVLKVTHGETHHLYQELLKFIYESRIVFPTESLALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTH0</accession>
    <name>A0AAV6UTH0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Guanine nucleotide-binding protein G(I) subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_025823</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(i/o/t/z) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000259">
        <property type="protein sequence ID" value="KAG8187785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTH0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008356">
        <property type="term" value="P:asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032291">
        <property type="term" value="P:axon ensheathment in central nervous system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060857">
        <property type="term" value="P:establishment of glial blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019991">
        <property type="term" value="P:septate junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007419">
        <property type="term" value="P:ventral cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002487">
        <property type="entry name" value="Guanine nucleotide-binding protein G(i) subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF227">
        <property type="entry name" value="G PROTEIN ALPHA I SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="176"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8187785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40392" checksum="C6C850FC6C9040A9" modified="2024-11-27" version="1">MGCAVSSAADKEAVERSKKIDKDLLADGERQAREVKLLLLGAGESGKSTIAKQMKIIHEAGYSKDECLQYRPVVHSNTIQSLMAIIKGMGQLKIDFADHQRKEDSRQLFTIAGASQDGELNPEMAAIMKRLWQDRGLQLCFSRSREYLLNDSAAYYLNALDRISQPNYVPSQQDVLRTRVKTTGIVETHFTFKGLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMTESIRLFDSICNNKWFVDTSIILFLNKKDLFEDKIAKSPLTICFPEYTGSNSFEDAAAYIKMKFEDQNKRKKTKEIYTHFTCATDTNNIQFVFDAVTDVIIKNNLKDCGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUJ0</accession>
    <name>A0AAV6UUJ0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000248">
        <property type="protein sequence ID" value="KAG8188122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUJ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8506" checksum="D6191A10CFDFF6E6" modified="2024-11-27" version="1">MSVSASLVAESFQEVGVSARNLLQFSYEPTFGLKKLLRSAEREVSLTAWKIVPIRRSFIVGTMGALLTYVVLVDSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVG7</accession>
    <name>A0AAV6UVG7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_008957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000242">
        <property type="protein sequence ID" value="KAG8188316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
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            <begin position="1147"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="1216"/>
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            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1166"/>
            <end position="1181"/>
        </location>
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            <begin position="1182"/>
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        </location>
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            <begin position="1219"/>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAV6UVM5_9ARAC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Oedothorax gibbosus</name>
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            <taxon>Arthropoda</taxon>
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            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
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                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAG8187828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="9493" checksum="9AB946A2F173CE69" modified="2024-11-27" version="1">MQWIVPFQTRPTHALISHQNSNHGRPERANYPPCWNEDVNRLQAPHPIGQQGGRIPNRKRFHLSRGFSPEPPLPLFKFFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Oedothorax gibbosus</name>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
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            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="12437" checksum="0660E2A7701203A6" modified="2024-11-27" version="1">MYRPFIRGTNLLHKCQSSSWETFNLRVIELQKIQQKKFQSIPEQQASPGPRLLTQSYLQKWLHFFLMYLLIHNKVAGKRLDLLALRMGRALPRLQEMRLAQKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAV6UWA3_9ARAC</name>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cholecystokinin-2 receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_012231</name>
    </gene>
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        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
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            <taxon>Linyphiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG8188760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWA3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015054">
        <property type="term" value="F:gastrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009126">
        <property type="entry name" value="Cholcskin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000314">
        <property type="entry name" value="Gastrin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF75">
        <property type="entry name" value="CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01822">
        <property type="entry name" value="CCYSTOKININR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00527">
        <property type="entry name" value="GASTRINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
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            <end position="226"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="55"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8188760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="378" mass="43053" checksum="A91572B455AFB19F" modified="2024-11-27" version="1">MTTSRDVYQQNFSLCFNESYEELNHTTTHMMNIRDTGAWRLILPYSIIFMLAVSGNVLVIVTLLLNQRMRTVTNVFLFNLAMSDLLLGVFCMPFTLTGVLYREFLFGSALCKLIPYFQAVSVSVSAWTLVSMSVERYFAICHPLKSRKWQTLSHAYRMITVVWVGSLLCMLPILVLSQLQKIKGTEKQKCRESWPSLSAEQGFNIFLDVFLLILPLILMSVTYALIIRTLRQAMLISTDETDQSSGRKVRSCWNSFPDLNRNAASTFSCTSGTSVSAPPAIRKNNSEHGIIQKKRIVQMLFVVVLEFFICWSPLYAINTVSLFHADVVYSKIGYSGVSFLQLLAYTSSCCNPVTYCFMNTRFRESFLAVFNCKCKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWC5</accession>
    <name>A0AAV6UWC5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_002445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000249">
        <property type="protein sequence ID" value="KAG8188088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWC5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000068">
        <property type="entry name" value="Latent transforming growth factor beta binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.20.10">
        <property type="entry name" value="Plasmodium vivax P25 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051586">
        <property type="entry name" value="PKC-binding_NELL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042:SF5">
        <property type="entry name" value="EGF-LIKE CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042">
        <property type="entry name" value="NEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043327902" description="EGF-like domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8188088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="370" mass="41511" checksum="388866AD9CAB1840" modified="2024-11-27" version="1">MIVRFGYWLVLLTVCCVTLANSEVYTDEVEFDNNTFVDNVPFQSDCDCGKFSRSCSYVEGKKKCICYDLYADKQGTCVSCYCKNANYYNRCEFDDSGSKKCNCLKGYAELNGDCQECNCGEHGNCILYAWGKTCRCENGYADNYGTCKECDCGEHGICSFSAEYKQCSCDSKFAENDFGKCEACDCGENARCTFNAGKKQCVCKHGFAENFLGKCKECDCKMDDSNCTIDGFAIKKCQCPKGFEQSKDNPVCIEKDECLSPEDNDCDPISTKCVNTRGSYDCVCKEGFQIIYNILGYYDIKKDGCKDIDECLDYSPCIHLHTRCVNTPGSYKCECTAGYSLEKDSYAEKYNYCSEGARPWKTASIVVQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYJ5</accession>
    <name>A0AAV6UYJ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Persulfide dioxygenase ETHE1, mitochondrial</fullName>
            <ecNumber evidence="13">1.13.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sulfur dioxygenase ETHE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_009190</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12981"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="EC" id="1.13.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Monomer. Interacts with TST. May interact with RELA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.18" evidence="13"/>
    <dbReference type="EMBL" id="JAFNEN010000230">
        <property type="protein sequence ID" value="KAG8188798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYJ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000013">
        <property type="entry name" value="Persulfide dioxygenase ETHE1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="16">
        <location>
            <begin position="19"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8188798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="243" mass="27117" checksum="AAF433700576D749" modified="2024-11-27" version="1">MIFKNMGIIFRQLFDSKSCTYTYLLADATCRSAALIDPVLEQVQRDLQLVKDLNLNLLYAVNTHCHADHITGTGAIKKLLSNCQSVISRSSGAKADRHLDPMEILKIGGIELEVRPTPGHTNGCVTYVCHKEQMAFTGDAVLYRGCGRTDFQEGDSATLYDSVHKQIFSLPESYLLYPAHDYKGFTVTTVGEEKKLNPRLSKSKEEFIDIMKNLNLAYPKMIDVAVPANMVCGYIEDVGEKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0S3</accession>
    <name>A0AAV6V0S3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_014438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000186">
        <property type="protein sequence ID" value="KAG8190332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0S3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19723">
        <property type="entry name" value="bHLH_TS_ASCL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015660">
        <property type="entry name" value="MASH1/Ascl1a-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935:SF106">
        <property type="entry name" value="ACHAETE-SCUTE COMPLEX PROTEIN T5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935">
        <property type="entry name" value="ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="98"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8190332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="243" mass="26850" checksum="3FB6DE365B86C018" modified="2024-11-27" version="1">MMNYDQDLELYIPEGQTISPFRGLPTPPTEPIHSPPTHKTLTQLDDGLPQQTLLNGVGGMTQKTSTPLDSVGGKQPAIGPKRRQRRGAAPRTPQQQARSVARRNARERKRVKLVNLGFATLRDHIPPHLGISTAPAPTKSSSNNNKTSNSNNKKLSKVETLRCAIEYIRQLREAIGYDDNDNMDFQSFDLLKDSSVEVSSPAETSSSFASNSSSPVPMLESPSLFDDDDENDDFFNIVDWTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2K1</accession>
    <name>A0AAV6V2K1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000202">
        <property type="protein sequence ID" value="KAG8189841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2K1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8422" checksum="0C2DDFE328F4B570" modified="2024-11-27" version="1">MGRLRSQKNEKSVMKALPEDGERNSNIPEKFWRCYKRGKTLPRYSVKEISFFLNGGNFEVLAGELVSLTSLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2L1</accession>
    <name>A0AAV6V2L1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_010325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000172">
        <property type="protein sequence ID" value="KAG8190900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2L1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8190900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="602" mass="66499" checksum="52D5435F7D658AB0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3S6</accession>
    <name>A0AAV6V3S6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_016662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000165">
        <property type="protein sequence ID" value="KAG8191149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3S6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8191149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17859" checksum="3A7303929DE34EA2" modified="2024-11-27" version="1">MFLNKFPTISLRLHRRLLGGLCNIRGYCDSKENGDDEKKVETVTINFVMHNGKKYQVPGIVGIDLRQAVVKADMMEKLDDFGFCGGNRWCTYCHCFFEPEVYKTLPEMCDVEKYYAEFLLNYKAGASRLGCQVDVTKEMDGITLFIPKRFPDQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5F8</accession>
    <name>A0AAV6V5F8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasomal ATPase second OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_006088</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5F8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasomal ATPase second OB" evidence="5">
        <location>
            <begin position="71"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8191342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="180" mass="20675" checksum="BEE767B0059EE81F" modified="2024-11-27" version="1">MASAAVAQAQAQIQPENPKDKALQDYRKKLLEHKEIEGRLKEMREQIKEFNKLYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKTKLKSGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGDITYNMIGGLGEQIRELREVLILKAIHRCSMSKLKNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7R8</accession>
    <name>A0AAV6V7R8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heme-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_016473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HEBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000154">
        <property type="protein sequence ID" value="KAG8191686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7R8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.80.10:FF:000003">
        <property type="entry name" value="Heme-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF1">
        <property type="entry name" value="HEME-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8191686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="195" mass="22340" checksum="4CFF0EDBC6CEC69D" modified="2024-11-27" version="1">MAFLKFVKGAIVGNEQPKYDVLSKTDDYELRSYPECQWVTLSIHDKTPDEFSTEDYKRLLDYINGKNESSLSIDMTAPVLYHVSPVEEKAKDYSVSFFLPAKLETPPGPLDTELALSETGAREIYVRTFTGMAKDEDWKREFDALKSKLDNPDDIDLSEYHRAGYDPPFKPFNRRNEVWIVKKSSSVVDPPSPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8C0</accession>
    <name>A0AAV6V8C0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Regulator of telomere elongation helicase 1 homolog</fullName>
            <ecNumber evidence="17">5.6.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_018036</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">A probable ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.-" evidence="17"/>
    <dbReference type="EMBL" id="JAFNEN010000139">
        <property type="protein sequence ID" value="KAG8192516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8C0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904430">
        <property type="term" value="P:negative regulation of t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090657">
        <property type="term" value="P:telomeric loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17970">
        <property type="entry name" value="DEAHc_FancJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000431">
        <property type="entry name" value="Regulator of telomere elongation helicase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03065">
        <property type="entry name" value="RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030845">
        <property type="entry name" value="RTEL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057498">
        <property type="entry name" value="Rtel1_ARCH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23109">
        <property type="entry name" value="ARCH_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 17" id="KW-0408">Iron</keyword>
    <keyword evidence="10 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="7"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="818"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="836"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8192516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="940" mass="105350" checksum="26D22586B7485EBA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8J8</accession>
    <name>A0AAV6V8J8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_028147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000132">
        <property type="protein sequence ID" value="KAG8193030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8J8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026521">
        <property type="entry name" value="THAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47696">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47696:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8193030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="335" mass="39020" checksum="66E3647DB90B688C" modified="2024-11-27" version="1">MVKSCSAYNCTNRHNAFDKHIKFFKFPSNPVKLKAWVRNIRRVDKKHKDWMPNKHSYICSVHFKPECMYTVKEGGRTRLKPDAVSTEFDFPSHFIKVIKERQTPRRTRRAPSPQQVPAVDISIDHNYGSKHVSELDKVKEQLKISQKQVTRSKIKLKQTRRKLTARTAEIENLKDILMELKDREMLKCEEKMFLNSMLPEATTELFRNAAKNAKRTNGRSFSTEVKSFAMSLYFMSPKAYDFVREKLFLPHKSTLHAWFKAIDGDPGFTEEVFSFLKKMSEDNKTRLTCSLAMDEMAIRKEIIFQGGTQTGFVDYGTDFSVELEAPAEWHCLTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBV1</accession>
    <name>A0AAV6VBV1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAM86 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_023716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000120">
        <property type="protein sequence ID" value="KAG8193464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBV1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029426">
        <property type="entry name" value="FAM86_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14904">
        <property type="entry name" value="FAM86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAM86 N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8193464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="290" mass="32919" checksum="053543BAA3A9F798" modified="2024-11-27" version="1">MEVFSPLTVETQTGILNVTIKNPTSKKFPPPLTFRKMFLKSLINIVEKYGSECSDDLVEEYSRILSEQVDDNEGYFSYKINEVDTITLQENTSFVAESTTGLQTWEASKYLSEWCIKNHFVLENKSILELGSGIGLLGITVLKFCSPSKYMFSDKSWAVLNKLAANIKINFENADNLPIEQHQLVWTTMNDEDAQRLLPDVILGADLVYDADMIESLVHALKTTLLNSSSCAYIANTIRNPETNEKFLNHLGAADLIYEELKTHEKDIFVYNKSSSFKMYKISKNKINCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VC57</accession>
    <name>A0AAV6VC57_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000118">
        <property type="protein sequence ID" value="KAG8193565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VC57"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10236" checksum="A9E29A7C5CCCC862" modified="2024-11-27" version="1">MVLSLLSYMETVAVSFHSSPSVASYCPPIETEVCDINRGAIDRSNKVGLPRRRDIDFTPPKTPFFGMKVCIRVLFKSGMDWRLSLKGGVRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCV4</accession>
    <name>A0AAV6VCV4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_013228</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCV4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="8" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="9" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8194470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="290" mass="33364" checksum="B7093CAF2F1C3800" modified="2024-11-27" version="1">MANEQEKNLHNVDSVHELERLLNSGANINERNVFYETPLITALRREVDFEVIRCFVQLGSDVNAKDCWGVSPLYCAVARHGRNLKLIKLLLDNGADIEGGKQINDRFLDHNVTHNLLCMKLLIKYKFLRNAHLLDLSFRPSSNLNRNYYEEYKAVVALDLKPSCYRYLRKFLDSCAAEVVRMLTVYVGPSVSLHHFITDSLLAEIPRKRCEPAAKEILDGVLAEILRKKYLIYGDMITSKIGRVHLIGKICEQLHHHAPVGENFPYHIVLDNVAKYFNKEELMNIVKAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDB5</accession>
    <name>A0AAV6VDB5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_011440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000113">
        <property type="protein sequence ID" value="KAG8193880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDB5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000004">
        <property type="entry name" value="xaa-Pro aminopeptidase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF20">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE APEPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8193880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="851" mass="95679" checksum="B4C86E4B86B15A43" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDM3</accession>
    <name>A0AAV6VDM3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000101">
        <property type="protein sequence ID" value="KAG8194647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDM3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="10645" checksum="89AE5157D9FE35FE" modified="2024-11-27" version="1">MSSAETLHFPSKGEIVSYLEQHPLTNDRYLTEKKIIEAVADFFADKDKTLMGVDMGVMLKLADLNEKLQLPQVALITININLTAALKDCAAGILPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VE17</accession>
    <name>A0AAV6VE17_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000113">
        <property type="protein sequence ID" value="KAG8193893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VE17"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33459" checksum="273AD7610313D4BE" modified="2024-11-27" version="1">MSCFTIIWKIENFNICLKNSNKAKCDYGGPVFKTDSTTGRNWWKLNVDFSSNLFYFSVRNLKGDPKETRYEINLLSSSGEVKLNYNSIFSSPKNTLYYSFIDKNEIFSEKEQSLLLHNTLTVCCKIRHPTLKSGECLLRTVLYKRDFIWKIEGLNAFVNNSALCHQGTLNMILTISKIGPGNYNAVVESLPSKDGWPAFVDGELAFVGKEKDRYVLPQSDSSSPHCMVWNIQISAKNNVSKFHLQLKAMVAVHMTHSEELSIPSDEKSVVPETVPALSTKLPDAIIYDTFLDRGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGI7</accession>
    <name>A0AAV6VGI7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase RNF25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_029663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000094">
        <property type="protein sequence ID" value="KAG8195084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGI7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16470">
        <property type="entry name" value="RING-H2_RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23818">
        <property type="entry name" value="RWD_RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000052">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase rnf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039133">
        <property type="entry name" value="RNF25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13198:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13198">
        <property type="entry name" value="RING FINGER PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="137"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="612"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="700"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="777"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="831"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8195084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="103432" checksum="6095DE59A0E62E79" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHK1</accession>
    <name>A0AAV6VHK1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_007899</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHK1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8196169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="56889" checksum="4B88772EEB0BD245" modified="2024-11-27" version="1">MDTVSVLVAVFVIFLLVWFTKTKYASNIPGPMGLPIVGYLPFMTKKPYLKLAQLRHKYGPIYRIHLGSREIIILCDFNIIKDAFTRDEIMGRPPDMPFDLSEETIRTEAFLGMPWKEQKRFSLHRLRDLGFGKTRMEEHLKEEIEELLERMNTETSKSTVRISDLLAPSMSNNIASFLFGKRLKYNNPRRKKLDELFSTIGKLNSVLALKMFFPWMGPFIKFFNIGSPKTLEKALEGVKEYVMEEIEEHEKTLDPNNIRDFLDGYLLEIEKRSNEPNTTFKRDVLCDMARGFFGAGSETVRVSVDWLLLLCAAYPEVQKKIHQEIDTVLGTERFPSFQDRFDMPYTEACICEMWRWKPTIPLSFLRYTLKDTELSGYFLPKHTRIMAVPYAVDHDEKLWGKDHDVYKPERFLNPDGKKVVKPEYFVPFSIGKRSCPGKSLAETEVFVYVTAILQRFEFSLPFGKKADLEGFLGIGIQPKRQELCLKLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKL4</accession>
    <name>A0AAV6VKL4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_014159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000067">
        <property type="protein sequence ID" value="KAG8196598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKL4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19136">
        <property type="entry name" value="AKR_DrGR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8196598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="284" mass="32177" checksum="C8EA90037B572E65" modified="2024-11-27" version="1">MSSVILNNGVNMPLLGLGTFLLQSPDVLPVTESALRQGYRLIDTAEVYRNESSIGQVLKKTNVEREDIFITSKLGPTHQGSEKAKMSALASIETLQLSHLDLYLIHWPGSAGIKTDNPLNAELRKESWLQLEDLYKEGKFKAIGVSNYTIQHMKELLQYCSVIPAVLQIEVHPYLTQTLLREFCEENGIHVQAYSSFGSRSGCKELMSDPTVIKIAQYHNKTSAQVLLRWAIEHGLSVIPKTCNLERLKENMDIFDFSLTSEQLQKLDNLDRQTHFCWNPEDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM33</accession>
    <name>A0AAV6VM33_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA processing protein EBP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_014489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the processing of the 27S pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000064">
        <property type="protein sequence ID" value="KAG8196756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM33"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8196756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31375" checksum="DF2189F2719359AF" modified="2024-11-27" version="1">MLYVYGDFNISSNAKMSDDSDASVDEGFAADVPSLSQQKRKIFPVNNKAGLLEKLNDYKLNLDWIEKVDITIDSSTLDDEPKGDKSNQTQPENDFKREMSFYNQALASVQKAFKRLKKRGIPTQRPDDYMAEMAKSDAHMVKVRKKLLNKQFVVERVEKVRAIREQKKQGKKIQREVIQQRKQEKKKMISALKSTKKGKMGADKLLQPNKPVNKGKKGKNREYRDSKYGYGGRKKGSKLNTAESSAEEKSSFKRNFKPKGGSLSRQKKSRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VN25</accession>
    <name>A0AAV6VN25_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000047">
        <property type="protein sequence ID" value="KAG8197959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VN25"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9645" checksum="153E595E47882657" modified="2024-11-27" version="1">MKFATEVGLLSQPDDSPKPPCPQCGADCKVTRDKNKKLGFFYTCTEMCTGTHKKSFEGCLVSRKIRVLMLPPTTHLANLRQTTIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNJ1</accession>
    <name>A0AAV6VNJ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_007542</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNJ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000679">
        <property type="entry name" value="Zinc finger protein 341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000618">
        <property type="entry name" value="zinc finger protein 341 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF70">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="407"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="584"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="617"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="339"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8197296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="811" mass="91341" checksum="FA0C078EA938ADE1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNU0</accession>
    <name>A0AAV6VNU0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000056">
        <property type="protein sequence ID" value="KAG8197401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNU0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="387" mass="44071" checksum="BB36631E002A13F2" modified="2024-11-27" version="1">MGATEFGATYITSFNGGERCHFTEDVPNMNSYCFNDFWEDFNIMEKDVKKFEPQFLSSRHAPVVPQMWKNSEYEMRFRFSSEMFTTIASSGTDDFSGVTKLQNMADVIRLSEPQVAKTSSYKQCNLSKFSSEEYVIDRKYGLEEPILDTETSPASSKFLIHSETTLALESTNKCAEEHDIPVSEKILNLRLRIKELIENSREMKQENAQKEEDNIPVSKKIRNLRLVIKELIEKFAGKMKEEIADQVYCQKEEDVLHESKLTQELEIGLDIPSKGSAEDSMTGSKLISVAATLDSAMSIKSPSKHHEDYEKTNLESFDVSSKDSQENCLKMDLVKENSAEKILSVDSTSLQIRGRKKRFIGWIKSKCLSALMFCCPCTTTKNSSRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNZ9</accession>
    <name>A0AAV6VNZ9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_020266</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000047">
        <property type="protein sequence ID" value="KAG8197886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNZ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="11" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="409"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8197886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="700" mass="80484" checksum="267018037233EC7F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP75</accession>
    <name>A0AAV6VP75_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_001604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP75"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8197679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="347" mass="36781" checksum="E3460A234E7FA122" modified="2024-11-27" version="1">MQLLNGNFSWKILYLLLLGLPCIQCHMLHYMHLKKFITAVAFARALGKRPTVLPIPIPIPIPIAQNEVIKLPMGGNGAKTTVIDGSKGSSQADTIAQLLGGIPNYASSLPGFASNNKFSFAQLPSNNKLSFAQFPSSNNPSVINLSQLQASDSNLVNSLATALSNGGQTKVLILNGGQNPKGSFSTSPSVIRIPVSNMNSHGHNLGGINLNGHNHGGMGPERQNLGGINPHGLNLGGFNQNGLNLGGFNQYGQNMGGLTGGIDQGMNGLSYSDLGLGSSLTNVAQLQQNERQPTQHGRNMHVGIGNTDNSGNSKLCVNCHRQQNQRSRSGQANFQNAPLSVKFTYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP96</accession>
    <name>A0AAV6VP96_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_029385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000046">
        <property type="protein sequence ID" value="KAG8197991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP96"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF28">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8197991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="475" mass="54273" checksum="6326D10098D0172F" modified="2024-11-27" version="1">MESPNDSYSPLTKSDIPYIDGEMETEDCKPDGSEPINSPPTNGTNNKDDKPTAGPTPDIVLSLMGRFSFPFLLISSVYQLFVYLNKLYQDSHAVEQYYADRTGYCIVSAACLLLPALMYIIYEVSAYIKDQEEVENKEVGTKVVHGMLLVPWQIKSRLEVMNFSASRVCQRRPLTPDELIEKSSLDRRAAVLEFFEEFYAGLTQLLLQLYIIVRCLDKNMEYQALTGEIIASGLTLMAMLAAVRRRDDYILTGFLSITGWLSITISRTVCIALATTVIHGWMALVCTVHGILMSIWITKIAMATYYRDDPSLVFTRKRKTALFFLVFAVFGLPSLTYWPILFELKKHRRPLIFLFVMLVENVVFVGLWVCFKEKSWGSHDHLFVFAAAGTFALGALFILFYICCKPKYTDEVVYDAMKNARNADSFGMYFEFCDKAFKLKIKEDLVKKLKSDREHKRVERKVSAINKEWFSCCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPU9</accession>
    <name>A0AAV6VPU9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_026516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPU9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8198619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="154" mass="17680" checksum="8FA276D43A21FA82" modified="2024-11-27" version="1">MSENCFRFRELTRTNPYSLSIGSDIHFTFATGEKTQKRSLAKSCVETDGNRPQQVKFRSKIDQQVNKREDAPTGDHEQSDVSIETSGCRVRDSHSGRGCRLGDGARTWRVGVFDTWRCFGRHCCAKSNAGLSFYFINAFKFDIMTIIIKYFINW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQZ0</accession>
    <name>A0AAV6VQZ0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000031">
        <property type="protein sequence ID" value="KAG8199094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQZ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="162" mass="18535" checksum="92320562E41AD44A" modified="2024-11-27" version="1">MQVLSCFQLTSFESLNQPCITLNYKSLPDSLPVHFNRVVKTYDSKHHISLFVHLTDPQRSPVTYPSAGKHLRPFASKQQFSFLGKFPKNFTSWKCLGFVAFKNVSFTLLIEILCGKSKSKIPEFQLFKEKRHREEIEFSTLAHNGNNRRHLKSGFGGVGTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT18</accession>
    <name>A0AAV6VT18_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000029">
        <property type="protein sequence ID" value="KAG8199223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT18"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="58"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="208" mass="23921" checksum="94DE503B2140AFFB" modified="2024-11-27" version="1">MQTELCNCETILNERPLTTVSSEATLAALRPADFMKEIKSSFVPDVKTQPDPNYLRRRIRYLQTIREAFRARFRQEYLGALYTRYKRKSFRPLKEGDIVLIGDDNKKRVLWPLGRVIESRPGADGVVRRVKLKTQQGELYRAAQRLYHLEVSSKEDWAGTKTVNSDIPSVPFETLKEDIPCVPLETVIKVPVTTRSGRMVKVPNKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTQ3</accession>
    <name>A0AAV6VTQ3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP synthase subunit s-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_016226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP synthase subunit s family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000031">
        <property type="protein sequence ID" value="KAG8199089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTQ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000168">
        <property type="entry name" value="Distal membrane arm assembly complex 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00076566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8199089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="286" mass="33690" checksum="BE11FBCAA0D61822" modified="2024-11-27" version="1">MVFILLLNQLKKFIKDRMLKLRAIKFCKAISKPWGYPSYSSGRQIKVHISRKEHYNDDETPYYSKPKPRESWVTNFYAVVQRRNWTMHDVDQWFKRRAMREIIADQRFVPERFLNLGPNLAAAHFITGRGGKVKFVGNDKWYSYADIKKGYIPSIDTPGFYVEEIDATDTPLCYEGFENLYNLRALKKLILRECFLIDDWCLHRTHIFKNSLQFIDVTGCPKVTERGIICLHPLRNLETLVIEDNPNIQNKELVCLLLQELAPKCNVIGVDFEDPVFLKRLENYMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VU88</accession>
    <name>A0AAV6VU88_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apical junction molecule ajm1 alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_021045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000032">
        <property type="protein sequence ID" value="KAG8199031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VU88"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058586">
        <property type="entry name" value="Ajm-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038825">
        <property type="entry name" value="Apical_junction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21517">
        <property type="entry name" value="APICAL JUNCTION COMPONENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21517:SF3">
        <property type="entry name" value="APICAL JUNCTION COMPONENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26649">
        <property type="entry name" value="Ajm-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043338937" description="Apical junction molecule ajm1 alpha/beta domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Apical junction molecule ajm1 alpha/beta" evidence="3">
        <location>
            <begin position="709"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8199031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="959" mass="105671" checksum="A9C5086B1F431697" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUL0</accession>
    <name>A0AAV6VUL0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000030">
        <property type="protein sequence ID" value="KAG8199136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUL0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8786" checksum="8C5CABBC5F11D466" modified="2024-11-27" version="1">MRFIKSSSTSIFGNHNSFSPETQPAKNFATLDSLPRQKSDRRTIDHLIKNSSEQGVFPRRFALKLRHGWTDRTAIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVG0</accession>
    <name>A0AAV6VVG0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">P3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_022338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVG0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043395063" description="P3 protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8200729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="55652" checksum="2E62E058BD3395B6" modified="2024-11-27" version="1">MILYIIGCLLFTIHVVHGVAEVSNDPPYHPHLVPSIEFYPQELKGIVEQEQRVVSFGIGWESSNDSIHDTSNNDQHDFLVSVVSEIPSILEISNSTSFPHCMRARDEQKNFSFTVKGAFVGYTKVRVNLQKGCSATHEPEDGATRNFELVVSVVRPPSLLVNAVTGIFAALVAFNYVNMGVQLDLACIGKVLKRPIGPIIGFVCQFLFMPVASFGISQLLLDDISLQLGLFTLGCSPGGSMSNFWTLLFDGDVNLSITMTFISTLAALAMMPLWIFTLGRTLFRDNNATIPYINLAGSLILLTLPIGIGLLIRQYSPRLTRVSEKIIRPFTIIIVLVGIGLGMYANSFVFSYFTWQVVVAGLAIAWGGYTFGALVAWMFRLDRAQIVAVSIETAFQNPAVAFVMLLLSLPQPDADLSSVPVTAQLLLTGIPMWALLLWTRAYRKSRQCFGRDEVDGCKIEKPEIDTVQKAYLAVETNPPDEEAEDIALEQSRWKKVDIVQFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVV9</accession>
    <name>A0AAV6VVV9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_022345</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVV9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2130:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="59"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="256"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8200740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="691" mass="78415" checksum="7EA132D7E15B656D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VW28</accession>
    <name>A0AAV6VW28_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_028502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000016">
        <property type="protein sequence ID" value="KAG8200318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VW28"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8200318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="394" mass="46459" checksum="743C1522BEE7BDB8" modified="2024-11-27" version="1">MAKKKKKSKAKKKPSTSKLERETLQIQIEDRQNRIEWRKAMLDVIKEDIQLSQEVFQLLQSDKENAIILLEDALKIQTLRNEQIRAAIPEADRKKTDSVNAKTQELSKFLLDNNEKKYKDLEELNTLQDSVNMIESYSVDKSDQKIVELEEICASDDEDKNIKRETLRRRQEEVLRAEMIEIFERKARDYQENCSKKLDKNIEKIVDETRWWKDSGDILCSMKDSLEQKNAAIYRKIKEEKENLKQRKDKALQVSIIVEEQKREIAKLEKRNVKLKQEEKEEAQLLKEQKILVSQRETAKQDLEELSSKLQEYKSITKYNEYFIQNIENKISKAKLLASDLKDVIETANNLITEDLELPLVKKDNEIPQPKNILQNLECLFEGATKLIFESQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWV8</accession>
    <name>A0AAV6VWV8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_024345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWV8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044023387" evidence="6">
        <location>
            <begin position="23"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="29"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="8">
        <location>
            <begin position="259"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8201477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="427" mass="48268" checksum="F410EA00867056B4" modified="2024-11-27" version="1">MLNKYLIIFLLHQSVLTSIVTAEDDENIIKERILKDYDKTLSPVLFQTSELNIYTFLTVLRVRGLDESKGEFILEGMLTTAWKDERLAFESDNVNRVFVNPEDVWLPHVKILNRVENDELTMKARVILFRSVVVFSQRYVFHTSCIPNLKFFPFDKHTCDIDIISMSDEFFPFDKHTCDIDIISMSDEGDILPANYTKQQVSILATIRTELTVENNLWTLVSTRSTPKQMDLDIGVKGFGCVYSFEIERTMPLIALGVLCPCLVSVLLLLTTFWMRPGAVTRTGMSATSILVSAGNLFTIGRILPVTGTTTPIIVEYITCALILALVSTLHSITISVLSHCVSQPPISYAAIVQKLPKWTLILLALNHDATKSAGPSFKFSELVESDSAHTSDESGGRVKRRVYSRRNADYRKFKITHITFTESKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W0D4</accession>
    <name>A0AAV6W0D4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W0D4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="10743" checksum="6CD31706461A47E3" modified="2024-11-27" version="1">MRRKALYEFNLSGNLHWDKTRSAGPQIHLPLWGCYSEPCWSNEMRSNGCIRTDLKIHGNKDSNGGFRYAEWLIVYVDWKGISEWCYEWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W254</accession>
    <name>A0AAV6W254_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W254"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="107" mass="11787" checksum="E1B864DDD33ED33B" modified="2024-11-27" version="1">MPHRPYLCRFLKDQVIDDPFPLSSNQPAHNSHLIKNFSLKSLGALGEGGSRCRTSPGFGPKTTLPTRHLSHAVIKGAPSSRLTMANYAPLKHKHQIAKSDYRSQRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W329</accession>
    <name>A0AAV6W329_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Y+L amino acid transporter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_010507</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W329"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF531">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8202148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="54946" checksum="8FC35BBAB88EF7A0" modified="2024-11-27" version="1">MAAESSDKSPESEGIKMTSKPTTPVEPQPESDAICLKPKMNLLNGITVIVGSIIGSGIFVSPKGVSKGTGSVGLSLVVWVTSGIFSMIGAYCYAELGCMITKTGADYAYIMESFGPFVAFLRLWVECMIVRPCSQAIVALTFSFYVLRPIYPDCEPPDTAIRFLACLCICLLTFVNCWDVKWATRVQDIFTYGKLLALGVIIVTGFIELFQGKTQYFNFDNSETDVTKIALSFYSGLFAYNGWNYLNFVIEELKDPHKNLPRAIFISCILVTVIYTLTIIAFHTTLSIQEVMGAEAVAVIYADRLFGNFAWVVPIFVALSTFGGVNGILFTSSRLFYAGAEQGQMPEILNMIQLNHLTPTPAVMFVALLSLLYLCSKDIYALINYVGFATWLAIGLAVVCLPYLRWKQPDLPRPIKVHLIFPIIYIIATIFITIVPMIAEPFDTGLGVLIILTGVPVYFIFIYWTNKPQCIKRLINGFTQTLQKLLVVVAAEKATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCP5</accession>
    <name>A0AAV6TCP5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007494">
        <property type="protein sequence ID" value="KAG8155659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCP5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8155659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="11298" checksum="6ADFD80AC5CE7DB7" modified="2024-11-27" version="1">MGEDSVSKKGLPLGHLESRNKCLPDPTYGGRGGPLTRLLCQNTQRDSARPCLHPPCAPLGITSVLVSSHIDFADLSRGKRFLHLVDFSPNGGSDTNAFYDARGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TE81</accession>
    <name>A0AAV6TE81_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006126">
        <property type="protein sequence ID" value="KAG8156249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TE81"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8156249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="129" mass="14233" checksum="A01C507B9D4B7220" modified="2024-11-27" version="1">MKEVGGQRTVWKRGRGVGGGKRGEGEGQVAGCGRKVRKRGKRGVGGVLKKRGSGGEVERGNDNRWFGQERGNGEEKGAGKMGKRRRKGRGEKKVGKEGREIGWGERRGEKEEKEKKEGGKDKEREGMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFR9</accession>
    <name>A0AAV6TFR9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005622">
        <property type="protein sequence ID" value="KAG8170326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFR9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7826" checksum="5A1B31EA62C63B7A" modified="2024-11-27" version="1">MFNCCSPGTLPPASVLKLSLEYFCYSPHQEKICTVRLQRAHARHLQRTHRDPPTHCGVNLHEGSSAVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TG01</accession>
    <name>A0AAV6TG01_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_024897</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005343">
        <property type="protein sequence ID" value="KAG8170496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TG01"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8170496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="116" mass="12444" checksum="B24E2B49868F2956" modified="2024-11-27" version="1" fragment="single">MVNLLHSQAGGFGLPFQVVGALLLTGTVVNMFLFTDTDDIPAQKVSARKLIANIDFLIDLICVSTCFATLGFNEATLEPHARQFNLTPTAIGGIFLISGVVDALFSPLWGYLAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TH62</accession>
    <name>A0AAV6TH62_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_014842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004332">
        <property type="protein sequence ID" value="KAG8171174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TH62"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8171174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="547" mass="59745" checksum="A254987FFC5A26D7" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THR2</accession>
    <name>A0AAV6THR2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004121">
        <property type="protein sequence ID" value="KAG8171349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THR2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="144" mass="16522" checksum="4CA6496B09310A22" modified="2024-11-27" version="1">MDKPTTRMSSTIFGLGSGITEEDCTITGSRLPTNLQVLRCLMYHLQEGVRINRTKWESAKIVLAKITVFYEKANIPMISERKACEKMIKLLDDNAKLRAIPCKRRETPSSLNKVKQMEDFLTKTFAIWPVNVETLMKNAEDLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THT8</accession>
    <name>A0AAV6THT8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004561">
        <property type="protein sequence ID" value="KAG8171016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THT8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="101" mass="11218" checksum="D8890C2FE11A38CF" modified="2024-11-27" version="1">MVASHHWPLDQAHEPSVRTCGSSRTEQDYYRNDESSVVRIHTENQDQASFCPFALREVSVLAELALGHLRYHLTDVPPSQTTHLNLSSSGSRATRSSALGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJD4</accession>
    <name>A0AAV6TJD4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003346">
        <property type="protein sequence ID" value="KAG8171954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJD4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="419" mass="47087" checksum="08A516F835D8ED0A" modified="2024-11-27" version="1" fragment="single">MASQRGKETPKTLLGIKNSSDYKKFNKVDSPKSCDILESWVVTLASEPELASFRDNVNALTVWLSEVRDLRLGYGMQNLMAGLFLDPILDGLKNFHRNTIFLKEEILRLTAENTKLKAENDLNTSQEERQELRLLTSENATLVSQSQELLSRVQFLEAKESALMDLKSDLDQKLSDAVAPVVKIINNKIDDLNNLTEVTFGKIREQETKVLNQYKTYLDEIKIGRRQEQELVKVIQAREDEVLRAAEKLLTTEVPEPAWLAAFLDKASSLGERVTSPPLGPPAAVPTVTSKVDVGASSGGLELVLLQDKGRSDFPGLSSGGLAAWRVCCAWCLGLRGRPWGKKPFHHRGTPTIKGPLYLILPQKYCHKIKYETTRTLGRRFSTHHVPRCILQRGEETTRVEKDDKRVELATRTAFNSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKI3</accession>
    <name>A0AAV6TKI3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002677">
        <property type="protein sequence ID" value="KAG8172470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKI3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF454">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="235" mass="27330" checksum="34A0A19F6793DAA6" modified="2024-11-27" version="1">MLKPCYKRPEEVNYLISDLEGENDEEQMEIPCVDSNPNILDLEEMFQDYGESSNMNEDQIAQMKKLVWKYMKCFSNVPGKTELVIHDIELSEEQSILSKPYRTSPRQNAILKTEIQKMLDLKIIEIGFSDCTSPMILVEAPGKDPRPCIDYRNLNKITKTKFFPLPNIEERIEIASSAQYITVLDLSKGYWQIPLTERAQRLAAFVTNFGTYKPLRMPFGLKNAIKNLVRWYINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLQ8</accession>
    <name>A0AAV6TLQ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C962R-like N-terminal AEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002434">
        <property type="protein sequence ID" value="KAG8172720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLQ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056443">
        <property type="entry name" value="AEP_C962R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23162">
        <property type="entry name" value="AEP_C962R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C962R-like N-terminal AEP" evidence="1">
        <location>
            <begin position="131"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="457" mass="52779" checksum="3B3F7EE4CB86B2B0" modified="2024-11-27" version="1">MNQPAQDIDNAYELLPDGETQRYRCKCDSLFGKPMVESIPFVCLVDYCIKDISQPLRNMGFSGSGCECAIYPHQDPNDLKSPCVLESTRVDQNVFTGRVDCTSEKSWVRKSIFCPDNTPMGHDAYFFYNMNYGKYYMDRKDYQQFCSLWFRKVQRQPLVMDLASAVQHRLILDLDFKPKTHGQPNTFMIPIIESALKKFLLQYCKHFTFIVTARGDGRGTHVHLPEFVIGHDDYILLCSQLRTELYYAIPDEGKYQLDTLVHCTLAGAAKPNNQPYQIWQIIYVDEKNTHNLSMGEKFSLMSQLQDHMKIFKRVKNNDKSFFRKLLILDETIAQDTLLEYMMPVPGQHPPLHKLAYPTVIGMIPGALSDGKDIAVFTNRGSNDLGYICKGQQLVVDGSQFLKTFYFLKHNTYVLTTLETDSYALKKWFDRIKRLHPSNIHSNPIFDKVNLMLQEKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TM59</accession>
    <name>A0AAV6TM59_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_027849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002500">
        <property type="protein sequence ID" value="KAG8172646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TM59"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035613">
        <property type="term" value="F:RNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000047">
        <property type="entry name" value="Roquin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048575">
        <property type="entry name" value="Roquin_1_2-like_ROQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052249">
        <property type="entry name" value="Roquin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13139">
        <property type="entry name" value="RING FINGER AND CCCH-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13139:SF54">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21206">
        <property type="entry name" value="Roquin_1_2-like_ROQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8172646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="275" mass="30678" checksum="FB95F78E58082885" modified="2024-11-27" version="1">MPVQAPQWTDFLTCLICCNEFECNIRRPISLGCGHTMCKSCLSKLQRKQCPFDQTVINIDINQLPENYALLQLVGGAIPEALPNNILSLSKDDYSYYLEAKKCVEELALYLKLPSSGATNGVLQNSPLSRPMQRKLVTLINCQLVEEEGRSRAMRAARSLGERSVTELILQHQNPQQLSANLWAAVRARGCQFLGPAMQEEVLKLVLLALEDSSALSRKVLVMFVVQRLVPHFPQASKTSIGHVVISLVAQLARCPIAVSLSEWVSRSRKQRFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNF5</accession>
    <name>A0AAV6TNF5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulator of rDNA transcription protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002049">
        <property type="protein sequence ID" value="KAG8173114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNF5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15065" checksum="28AAC9DC2CC18A36" modified="2024-11-27" version="1">MIGRADIKGSKSNVAMNAWLPRASYPCGNSSDTSCIKLVKSKGLIGHAFAVRIHTENQDQASFCPFALREVSVLAELALGHLRYHLTDVPLQPNNPPESVLGADRALQGGSALGARSVILTGRFPLNRVSKETMKAVVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TR59</accession>
    <name>A0AAV6TR59_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_005898</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001294">
        <property type="protein sequence ID" value="KAG8174179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TR59"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="8" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="9" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8174179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="59449" checksum="18EA10F4CDD1DCC1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRA4</accession>
    <name>A0AAV6TRA4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001227">
        <property type="protein sequence ID" value="KAG8174397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRA4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17015" checksum="B1D92597F91D9F6B" modified="2024-11-27" version="1">MKRHNGWENYLKSGCEQRGNTVHAEPLFDGPNGALKPDLVVYGRDQIAVIDVQVVNDQFPLKVGHGNKVSKYSVLKDKLKGLRTREPVFTSLTMNWRGAVCGASAEELLGLGLISRRDLKVLSVRCLEFGIEGWRVHRKMTSFSGRVMYDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRE2</accession>
    <name>A0AAV6TRE2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005360</name>
        <name evidence="2" type="ORF">JTE90_015959</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001213">
        <property type="protein sequence ID" value="KAG8174454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010000774">
        <property type="protein sequence ID" value="KAG8177558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRE2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="9057" checksum="D1ED992D88920710" modified="2024-11-27" version="1">MEDMGLSTGLDVPAASEAIAGFYIYDEGAGFNRHFDKAWIENAEHHVEEYDGTHTCQKTDSNRDASEFHCKDRIDTFHTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRM4</accession>
    <name>A0AAV6TRM4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_002224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001264">
        <property type="protein sequence ID" value="KAG8174264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRM4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8174264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="434" mass="49027" checksum="151665434942583C" modified="2024-11-27" version="1">MAELRSAPVYKKHNPGSQAPVSCPRLKEFISSLKSKVIPNENTDESVILDLCINLQKFMTTYIKTQLSYGTQNVLVGEFIGPLIEMALSNANTRLGSPRTSTPASQRSYSLSDSDRKKTQLNLDAANREIIKLRDLIQVNIDKATNNDHTARVKITELENEIKLLHQAQTNFLNNAVNLKEAQGTLEEAYNARNLELVETATKNQALLEGTYKDKLKILEDLRIERTNAAQKDESHRQELMETMRNQFTKMFDEEGKHLDRVLKRSTEESLYNLTHPLPIPSSSAPLPASPQDLPPDQNRFDGILVVLVDKPSSSPLSLDSFQTRLSQASLEAKMPFRCNGTFTTKTGFKISLPTEEDQDIVADLLRSSPSLQDLKFKIPRKIKPQYIIKFTSISDAEDFATDLVARNPFISRDTFKVVFSMKAKEDTHWIIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRM6</accession>
    <name>A0AAV6TRM6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_011635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001241">
        <property type="protein sequence ID" value="KAG8174359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRM6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051963">
        <property type="entry name" value="Adhesion_GPCR_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930:SF4">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8174359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12556" checksum="6459D06726421DF9" modified="2024-11-27" version="1">MFPRGRNKLNAIDLQYNMISTLPNDMFSDMPALKYVYLAGNMIAVLPEATFQPVISQLFHLDVSGNSIKCDCLIAWMLQLKVPFGLRGNCYAPKALRGKEFDQLTRSDLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRW4</accession>
    <name>A0AAV6TRW4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001264">
        <property type="protein sequence ID" value="KAG8174273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRW4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="290" mass="31380" checksum="1449947EB155CE28" modified="2024-11-27" version="1">MLAKYNGINFDFFELLRVAAKADVSFKIKLNLASEGIRTRAARVAGEHSTTEPPMPAKNNGINFDFFVLLRVAAKAEISIIIKLPLASAGNRTRAARVAGEHSTTEPPMPAKNNGINFDFFVLFRVAAKAEVSIIIKQSLASAGNRTRAARVAGEHSTTEPPMPVKDNGINFDFFVLLRLAAKAEVSIIIKQFLASAGNRTRAASVAGKHSTTEPPMPAKDNGINFDFFVLLKLAEKSDVSFKIKQNLASAGNRTRAASVAGKHCTTEAPMLAKYNGTNFVFFVLLKLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSW9</accession>
    <name>A0AAV6TSW9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_025050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001164">
        <property type="protein sequence ID" value="KAG8174707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSW9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF16">
        <property type="entry name" value="JERKY PROTEIN HOMOLOG-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8174707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8828" checksum="2F66FD7887220D6E" modified="2024-11-27" version="1">MGGNEDFPASEGWLNRLKKGHGIHALSICGEKFSSDPEEASKFKTSFEKLVNEKNLSKEQIYNVDETGLYYRMLPSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVU6</accession>
    <name>A0AAV6TVU6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000950">
        <property type="protein sequence ID" value="KAG8175781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVU6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="134" mass="15133" checksum="263230589A41DE52" modified="2024-11-27" version="1">MARRKRSAVASKQNAQKRMCSEQQTVNRTENETNSTAPGSADSQEKLNQRFSTIENSINKLRTENVHDNEVNGDSPNYVVVDIGALMQLSRDKIFDYLIKFAIKVPTPHLKCIKDSHKLSVTIDLDTIKKEDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWR0</accession>
    <name>A0AAV6TWR0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_015018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000939">
        <property type="protein sequence ID" value="KAG8175914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWR0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF16">
        <property type="entry name" value="RING_U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8175914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="298" mass="34368" checksum="BC8379E5287B8BFF" modified="2024-11-27" version="1">MHPDTPFLLILVHEKNTSLLYMSKRTGIYYDDSNRGHSKSVYMRVTMHDGNCVYGHCTCSSSIGFTQHVGSFKYLNVRNETVYNLLHLPSCNGRSCVCTKTLLDQGFYKIHMEVHDTHLTSNMELDASNVNMTQFLHQYPWSLLCPYSVVVLEKELLDLVRSEEHVEEDRDSLSFNFLLDDIPLTLSELNWTYTDSSSDSDDFFGLSTEEIEKLESVEMNQSHVEQGMDCSVCLQRFELHEQVTRLSCNHFFHKVCISTWLEKHLTCPFCRLEVSKEETDSSDTDWDGIGLVVLTLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXS6</accession>
    <name>A0AAV6TXS6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_020362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000869">
        <property type="protein sequence ID" value="KAG8176526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXS6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.310.10">
        <property type="entry name" value="Serpins superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8176526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="176" mass="19769" checksum="40DFE63E4DA04CA1" modified="2024-11-27" version="1">MMHKKDRFGYAERDSFTLLHLPYVGKNIAMMVLLPRFMDGLSSLEKQLTTKFLEELRKEMRPIKVNVSLPKFKIEYTKSLVGTLQDLGMRSAFEAADLGGMSCSQDLYVSDVFHKAVVEVNEEGSEAAAATAVMVGLRCMPIREVVPDFVVDHPFLFAIVDMKSNATLFLGRISEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYW0</accession>
    <name>A0AAV6TYW0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000856">
        <property type="protein sequence ID" value="KAG8176681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYW0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="82" mass="9682" checksum="B0BD28E5DF760DB7" modified="2024-11-27" version="1" fragment="single">MRKISCRSFLTLTDTDEILKDESNVWWKCESLHVDPWIAKRSKLEQSRRIEDKSGLFNTLEYFNLDGKAVADWIDIFGPFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0Z8</accession>
    <name>A0AAV6U0Z8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Laminin subunit alpha-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000757">
        <property type="protein sequence ID" value="KAG8177719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0Z8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1230">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="64590" checksum="36F396197A479CF0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1A1</accession>
    <name>A0AAV6U1A1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_008855</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000755">
        <property type="protein sequence ID" value="KAG8177754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1A1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010623">
        <property type="term" value="P:programmed cell death involved in cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000158">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000160">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000009">
        <property type="entry name" value="Ubiquitin-60S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="65"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="131"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="207"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="283"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8177754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="334" mass="37568" checksum="56F56E301C22EA2D" modified="2024-11-27" version="1">MKNLQLPNGALDANLPRSISTFIWNFPALSLSQHPEPHCVNQQTCVISRGINIVLSNIYFIEFKMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAVRFNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1S4</accession>
    <name>A0AAV6U1S4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">sn-1-specific diacylglycerol lipase ABHD11</fullName>
            <ecNumber evidence="3">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha/beta hydrolase domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_011843</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48596"/>
            <dbReference type="ChEBI" id="CHEBI:11152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:90605"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77107"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:77129"/>
            <dbReference type="ChEBI" id="CHEBI:186738"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75468"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38503"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:77272"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000733">
        <property type="protein sequence ID" value="KAG8177951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1S4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="26"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8177951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="288" mass="32159" checksum="90901B606DAB49CC" modified="2024-11-27" version="1">MPSYTPVKLAFSVVVPKNGVSEKPPIIFAHGLSGSKEHWEDFTQLFADRTKRKVYAIDARNHGDSEWNDVFNFDCNVDDFLHFMDSEKISKAIIVGHSMGGITGIKMALIAPERVEKLIVEDMSVSPPPAEVIGMVVSVLSMLKNALQVLPKGVDEATAIQMLFSIVLSQIPEEVKSNFVKPESFQKLKIAFKRLEDGSLTFKANLDILLKFIKEAKDVQEAVEGVYEGPAFFLYGKLSPFHAHLDEPSVKKHFPKADITSIENATHTVHFDQPEEFAEAVLNFILKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1V7</accession>
    <name>A0AAV6U1V7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_026861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000776">
        <property type="protein sequence ID" value="KAG8177515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1V7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043507355" evidence="2">
        <location>
            <begin position="27"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8177515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="802" mass="89730" checksum="4FEE4DE045436C5C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U230</accession>
    <name>A0AAV6U230_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_007056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000718">
        <property type="protein sequence ID" value="KAG8178071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U230"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="43"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8178071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="185" mass="21294" checksum="775E9483CB88FB53" modified="2024-11-27" version="1">MFSSLIRDLYDPFDYRYNVVPRLLLEDYTPSHSHPHIHFNVIRPRRQNSTQNEGSDDSNKFQVMLNVKHFSPDEIDVKTVDNCIVIHGRHEEQADEHGFVSREFTRRYQLPDDVEPEKVKSSLSRDGVLTISAPRKALEPPPKNERIVPITIQRPAAVEEAQKQQQQLQEQAAAAANQSGEPMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2A4</accession>
    <name>A0AAV6U2A4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Intraflagellar transport protein 172 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_000796</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IFT172 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000734">
        <property type="protein sequence ID" value="KAG8177933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000008">
        <property type="entry name" value="Intraflagellar transport protein 172 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000012">
        <property type="entry name" value="intraflagellar transport protein 172 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002910">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="9">
        <location>
            <begin position="626"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="10">
        <location>
            <begin position="963"/>
            <end position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8177933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1746" mass="197305" checksum="2DA946F442F7647C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4C9</accession>
    <name>A0AAV6U4C9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dedicator of cytokinesis protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_011611</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000675">
        <property type="protein sequence ID" value="KAG8178683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11697">
        <property type="entry name" value="DHR2_DOCK_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11872">
        <property type="entry name" value="SH3_DOCK_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000004">
        <property type="entry name" value="Dedicator of cytokinesis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000004">
        <property type="entry name" value="Dedicator of cytokinesis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.350:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="12">
        <location>
            <begin position="431"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="13">
        <location>
            <begin position="1237"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1665"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1694"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1736"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1800"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1817"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1852"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1891"/>
            <end position="1912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8178683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1928" mass="222867" checksum="D6BE074A4C019BFB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4P8</accession>
    <name>A0AAV6U4P8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000656">
        <property type="protein sequence ID" value="KAG8178967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4P8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1086" mass="123839" checksum="EEDD63CEE313BEEF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4X7</accession>
    <name>A0AAV6U4X7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium channel voltage dependent Kv4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_010257</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000633">
        <property type="protein sequence ID" value="KAG8179362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4X7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005250">
        <property type="term" value="F:A-type (transient outward) potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024587">
        <property type="entry name" value="K_chnl_volt-dep_Kv4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF105">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11879">
        <property type="entry name" value="DUF3399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel voltage dependent Kv4 C-terminal" evidence="10">
        <location>
            <begin position="94"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8179362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="180" mass="20015" checksum="B016B2A7701C2422" modified="2024-11-27" version="1">MVPATPTGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQKKARMARIRIAKATSGAAFVSKKKAAEARIAAQESGQDVDDFPEDIFELQHHHLLRCLEKTTDRQFVELEAPYNGQPNRPSSTPPHSPTPTLSFHHDRRTGSLLRACCCCVGRGRKKYQVRYDEETRVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4Y8</accession>
    <name>A0AAV6U4Y8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-latrotoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_024663</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Homotetramer in membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cationic peptide 01 (latrotoxin) family. 03 (alpha-latrotoxin) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000666">
        <property type="protein sequence ID" value="KAG8178801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4Y8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="12" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8178801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="304" mass="34153" checksum="D5EB76C63EAD08EE" modified="2024-11-27" version="1">MSEVGNVDVNDAQEPSNSEVVENSKDDIMALDKEERDPSQNEPPKSVNKESENQEPVPNEQQESNDTDDTKIQSSPGLQDSNKEQTTSTEEKERQTSVESKDRQSSVESKSQQSAWSYSQWSEYESLEEERPIEDFNGDKTKMILWAAEKNELETVRKLLEEDPNLVNAKDNDLYTPLHRASYSNNIEVIKMLLSYDADIHSRTTDGWQALHCACKWDSVEAVSLLLQNGADVNAQTKGHITPLHLAAQASNTSGRRTLELLLWQPYIDPNVVNDAGDTAYDIACRMGPLGALFEILEDSVNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U536</accession>
    <name>A0AAV6U536_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_012496</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000655">
        <property type="protein sequence ID" value="KAG8178983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U536"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8178983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="59917" checksum="80704680C2DAE489" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5S5</accession>
    <name>A0AAV6U5S5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000639">
        <property type="protein sequence ID" value="KAG8179286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5S5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043596775" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17967" checksum="B69D5E774CF5A954" modified="2024-11-27" version="1">MLHRAGLCGVLLCWVVFVLSVSGRVEISEYESAYDCLHKHVCDCNFEQRYQTCFYKLSEAVIDGIEKLAYQKFNEIENIQQSLDTVWSVLCREPKDVFLPFYAEALDSLKVYKNNQSRNAEISEEQWMREAFQFNDAGECVIPLIARCLGTVPDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U676</accession>
    <name>A0AAV6U676_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">JTE90_007625</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Receptor for basic fibroblast growth factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000634">
        <property type="protein sequence ID" value="KAG8179353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U676"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902533">
        <property type="term" value="P:positive regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000593">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 24" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043978180" description="receptor protein-tyrosine kinase" evidence="24">
        <location>
            <begin position="25"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="26">
        <location>
            <begin position="42"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="326"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="129"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="22">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="22">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAG8179353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="629" mass="70381" checksum="8960FF3DA98CF0CC" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7A9</accession>
    <name>A0AAV6U7A9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Voltage-dependent anion-selective channel protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_027884</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000586">
        <property type="protein sequence ID" value="KAG8180105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7A9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000001">
        <property type="entry name" value="Voltage-dependent anion-selective channel protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8180105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30905" checksum="4EE4293F6380E45B" modified="2024-11-27" version="1">MAPPCFSDLGKQARDIFNKNYHVGTMKLECKTKTATGVNFTVNGVSNNDTGRVNAFLETKYNVKKHGITIREKWNTENILATELSVEDQFVKGLKLSLDTSFAPQTGKKSGTFSTAYKNEHVHLNSDVDIDLAAPQFHGAGVINYQNWLVGAKISHDFGKNQLTKSNVGLGYSLGDFIFHSNVIDGQEFGGCIYQKVNPQLESGMTLSWIAGTNETKFGLGCAYKIDDYTSVRAKVNNNSQIGLSFTHRLRKGIQLTLSTLIDGKSFNQGGHKVGLGLELEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9K7</accession>
    <name>A0AAV6U9K7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000548">
        <property type="protein sequence ID" value="KAG8180799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9K7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043585792" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="7882" checksum="DFBDFFBB22B3E2F7" modified="2024-11-27" version="1">MKLLYVVLLIGVLGSCAADTESKPPFTCYIVTPPCPPLEHIGDPTVNCYLVPTGKPCPYAECVCDPVKKDEGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9Q7</accession>
    <name>A0AAV6U9Q7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000539">
        <property type="protein sequence ID" value="KAG8180944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9Q7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="348" mass="39612" checksum="2E935CB5CAFE88B1" modified="2024-11-27" version="1">MYIKRIFYDTDVLLKARKRAKEAEVTSDVGTTDTDAPRPIINPYSEDSEDSADSPSLLRNQKDFPNSKSISEVYEPLHQSTPLASHQAKILAILVEIREQNNQILQSLKQRETQEASTSKAAIELPVHLPISNEREYLKLETHLGEPANFSNFCIYLSARIWKGDVTRAVNFTLRHIFTDHVASLFNFKGTKEKKPFGSTSLCCVLIRQTSNYTTRDRYEIAPLALREKVPPMEFYEPFCGETKDLVLVEQKMQLWEKGLSRLTRIKTEGQCETMLHTISSNVPLRRKAGATIKVQSTSIARRSATVVRGNKRLFSRRPVTASSSKKRKHNLSYNVKLNQPNAKKNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UC80</accession>
    <name>A0AAV6UC80_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_017520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000514">
        <property type="protein sequence ID" value="KAG8181458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UC80"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="347"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="610"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8181458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="840" mass="95883" checksum="E6F0B29EE54EAD6A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDR3</accession>
    <name>A0AAV6UDR3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_012025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000484">
        <property type="protein sequence ID" value="KAG8182003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDR3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000046">
        <property type="entry name" value="SIX homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF33">
        <property type="entry name" value="PROTEIN OPTIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="148"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="150"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8182003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="349" mass="39928" checksum="34C6265D5A26F0A6" modified="2024-11-27" version="1">MKHRSQMALGLSQPTPIPGYNPMVFLPTLNFSISQVAAVCETLEESGDIERLGRFLWSLPVAHPNCAELNKNESVLRARALVAFHTGNFRELYGILESHRFTKVSHSKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKYPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLLQQQMQQQQLQHHPNSGSTQRSQTVVHRLSSSSSRGGGPGETTDDNTNGSFGSFDSPPGSPRCLSPAPVSTTSESSSRTPSPRHRLQTSIINNNHHMTMFQHQHHQEQRQSLNLSQHHHRHRDPLASILHRDRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDV7</accession>
    <name>A0AAV6UDV7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000483">
        <property type="protein sequence ID" value="KAG8182043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDV7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="1">
        <location>
            <begin position="574"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="649" mass="73728" checksum="8BFD58B8941749A3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF10</accession>
    <name>A0AAV6UF10_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_028187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPATCH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000467">
        <property type="protein sequence ID" value="KAG8182343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF10"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="709"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="775"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="709"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="799"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8182343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="862" mass="96652" checksum="2942CCD744A7A908" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJD8</accession>
    <name>A0AAV6UJD8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_013205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000382">
        <property type="protein sequence ID" value="KAG8184229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJD8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17683">
        <property type="entry name" value="RUN_RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058732">
        <property type="entry name" value="RUNDC1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047343">
        <property type="entry name" value="RUSC1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591">
        <property type="entry name" value="RUN AND SH3 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591:SF19">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26030">
        <property type="entry name" value="RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="3">
        <location>
            <begin position="391"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8184229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="580" mass="66340" checksum="A7ECB91315B6F4C3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJW5</accession>
    <name>A0AAV6UJW5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000365">
        <property type="protein sequence ID" value="KAG8184672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJW5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="114" mass="13067" checksum="E33035A30620E6F1" modified="2024-11-27" version="1">MSYTKQTLLKRYNPKDNVQARKPTSTLMRHPIQNPLHYNKAPSTDSHNLTDPINKITRFSQIHGRIIPAHLCIRDDNYPQDVRIHPHCTLGYSSNYSQTLRNSSPKISAALEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULE9</accession>
    <name>A0AAV6ULE9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipase A2</fullName>
            <ecNumber evidence="5">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphatidylcholine 2-acylhydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_020013</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phospholipase A2 family. Group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000352">
        <property type="protein sequence ID" value="KAG8184967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULE9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04704">
        <property type="entry name" value="PLA2_bee_venom_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.90.10:FF:000002">
        <property type="entry name" value="Phospholipase A2 group III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043417335" description="Phospholipase A2" evidence="16">
        <location>
            <begin position="31"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="17">
        <location>
            <begin position="56"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8184967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="190" mass="21822" checksum="821AC23E675C81CA" modified="2024-11-27" version="1">MSFTKENILKSVTLALLCFCVRVLVQGSWGKERLTIEEIRENYEEISKAAEDYDIIFPGTKWCGNGNIASNDSDLGGQVDTDRCCRSHDMCNDTILTGETGHGLRNDGPFTGLNCRCENDLYDCLRNVDTFTSNTVGNLYFNILRSRCFREDYPQTDKCKIYEISYFTCVEYEKDTTKPKVYQWFPAKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULV0</accession>
    <name>A0AAV6ULV0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial ribosomal protein L41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_012148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000366">
        <property type="protein sequence ID" value="KAG8184663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULV0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8184663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="20204" checksum="8DFA0824112AC10B" modified="2024-11-27" version="1">MASRCFFKNNFVLFKCTRSFIYQVTKRDISTSSTLCGKRNFRKFLYHTRGTPLDHEYYKENPQLVDLRGMRPAGYYEGKKFVHVPEMIPELVVPDLTGFTLKPYVSYRAADIEQEKFTPEHLYHATYAKKLTKDFKEGKLDADGNPLEPSEQEKMDAEEAFRRARKTGSDFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMP2</accession>
    <name>A0AAV6UMP2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000331">
        <property type="protein sequence ID" value="KAG8185569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMP2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="13817" checksum="BADC95FF778FC2DF" modified="2024-11-27" version="1">MSDRKTSKAVLVSSDEEDFVPLKRKMKSSGEVSKKGKRNLKVDLNLGEAAVPRVALPPYSIYLGSDILLEVKPFKKEFYLGFSKNVDGEVKNRFNVNIKMIRTVKRAIDAVIEHLEANNFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMY6</accession>
    <name>A0AAV6UMY6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_017019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000349">
        <property type="protein sequence ID" value="KAG8184991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMY6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8184991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="177" mass="20944" checksum="DD16E720323F5417" modified="2024-11-27" version="1">MSLLTKASTKCRLFVSAIRCPMQVAERVYAKTILGGLTGKGKIMGAAFEKKKRLPVETDPHKLVNYCCGSNILKEGEDFKLREDSEYPDWLWTLRLGPPGPLEEMDPNTKEYWHRYFFLQECRRKRLMKTQDKKKLRINEQDKMYLLRKIRFRALAYKYDPGFDKPPQFDKDGWRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UN22</accession>
    <name>A0AAV6UN22_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000353">
        <property type="protein sequence ID" value="KAG8184955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UN22"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="142" mass="15841" checksum="3E25AF273D79AF5B" modified="2024-11-27" version="1">MASNLHSPEVRPADNAGYRTPTARQYRIPEGRPPDIAEHRISDHQTLPDSQLLDIAGDRIPGCQTLQETGCPTARHCGPPDIARDRIPDHRTLRETGYRTTGHCARPDTGPPDIARDRIPDHQTLRETGYRTTRHSGRPDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNW2</accession>
    <name>A0AAV6UNW2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_023900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000341">
        <property type="protein sequence ID" value="KAG8185291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNW2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000013">
        <property type="entry name" value="Mitochondrial intermediate peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="11">
        <location>
            <begin position="248"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8185291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="698" mass="79952" checksum="604FA999517BB5A2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNX1</accession>
    <name>A0AAV6UNX1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_018629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000336">
        <property type="protein sequence ID" value="KAG8185409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNX1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8185409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="161" mass="17427" checksum="38E6DFB1A8B3577A" modified="2024-11-27" version="1">MLEAFSNSVVWIVVLAFLIAFFLAFGVGANDVANSFGTSVGSKVLTLRQACILATIFEILGAILMGFKVSDTVRKDIYDLEMYNDEEKLLMMGNLAALVGSSVWNMVATLLRLPISGTHSIVGAVLGFTFVAKGFRGIHWKTLGFIGSETRKRVELETGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTX4</accession>
    <name>A0AAV6UTX4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000282">
        <property type="protein sequence ID" value="KAG8187001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTX4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL" evidence="1">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="9683" checksum="28B90A35A873C2C9" modified="2024-11-27" version="1">MSFSLAVVAGYTRAAGGYRCPDNVSQEECQSYECPKNGELVECINFCNTCEQASVCIDYCAPGCDCKKGFLRDTKGNCIPKSDCKKGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUU3</accession>
    <name>A0AAV6UUU3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000275">
        <property type="protein sequence ID" value="KAG8187265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUU3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="8737" checksum="618BC1B75755016C" modified="2024-11-27" version="1">MARPPSLNTSLRPEDNKTCGSRTLCTGESGRKPDRGIRPLVTMRSGCGRRGSIRRGWPENVRRHLGAGSGTPRHRSLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UV45</accession>
    <name>A0AAV6UV45_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000265">
        <property type="protein sequence ID" value="KAG8187633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UV45"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="102" mass="11592" checksum="55771E75F1A539F4" modified="2024-11-27" version="1">MTAPPLVDPDLLFFCNLSTLLLDTEWQRRLSRRFSKDGEDSFCWDNKDLPIGQKASASGKNRKCFLDADLDALLQRRKEALSQNGVREKGCRAEKVANVAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UV53</accession>
    <name>A0AAV6UV53_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_015598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000261">
        <property type="protein sequence ID" value="KAG8187728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UV53"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="589"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8187728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="633" mass="71380" checksum="6B3F69D2C0543605" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVC4</accession>
    <name>A0AAV6UVC4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000277">
        <property type="protein sequence ID" value="KAG8187201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVC4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="8885" checksum="BB08129B758A188B" modified="2024-11-27" version="1">MDKTRPESPGGRAEVFRAVQRAVAGEPKQKAESFMIRTCRVIWSCSEAEGSEDLEKRAQRIISLPESASAASAEESVLTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVX0</accession>
    <name>A0AAV6UVX0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000241">
        <property type="protein sequence ID" value="KAG8188339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVX0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="373" mass="43404" checksum="D138B1914959A3E3" modified="2024-11-27" version="1">MDLRQGSLKDNKLKIRHHTVGKYCAYYLIFYQDNCVEINLKDYDHSEYFDGENRFSLEHLTELERKHCRKPLSRRTMELDHIIPPVEDLQHPHDFYQDEHFPRLGTKTNAGDSFAGKQCSSKLKGPRTHVSKGNKTSRDNESRMRRTSGYCAYDLIISEDNCRVVNFKNGNGLKKKSSLTLQPQSVKNFNSRDYYQTMHHLGTQASENNNLVYNHVPNKLDGSTTNVRKSSEKTSEDKYRIGHTEKYCAYDLVIGEDNCTVLNYKNQNDSKKNPVTHQPQISHCHQGFHPECTQSTDSLPSKYSEFTQSTDSLPSKYFGGDGRNFCLEDYLLELKRIKSRKPSTKRMMEFLDNSQQVKDFDMNDYCRKINFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UW36</accession>
    <name>A0AAV6UW36_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_026752</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000234">
        <property type="protein sequence ID" value="KAG8188647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UW36"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22031">
        <property type="entry name" value="HMG-box_SoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000004">
        <property type="entry name" value="Transcription factor SOX-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022151">
        <property type="entry name" value="Sox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050917">
        <property type="entry name" value="SOX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803:SF5">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12444">
        <property type="entry name" value="Sox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="51"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="51"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8188647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="282" mass="31609" checksum="57AA1CDF1B59DE60" modified="2024-11-27" version="1">MEQNPDSSGQYPASIRAAVSRVLQGYDWSVVPSPVRSTGSGTGGDRRKPYVKRPMNAFMVWAQAARRKLADQYPQLHNAELSKTLGKLWRLLNEEDKRPFIEEAERLRVIHKREHPDYKYQPRRKKATKSPNEKPPQPSTQANTAIVFRSLKYSDSSDSGSVKTEESVTGGAPSSPPTPPTSPLPSMQAPHINRRLKTDTTTYEPAIDFSYVDVGQLTREAMDNLDETELDQYLPPPSTLRQYIGLVPPLVEDFNIGPYPVNTASYVGGGNFNSSEEHWTCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYG4</accession>
    <name>A0AAV6UYG4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000214">
        <property type="protein sequence ID" value="KAG8189477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYG4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10110" checksum="1E08045D2578CBF3" modified="2024-11-27" version="1">MQVLGNAGGKLVSKDLRPNKVNEIDFDLYTGAEDETHKVEGSLGAPHLSEQTIKKKSPNKTLADDYDPMMSHTCLLQHTRLSKVKTCLSGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZC2</accession>
    <name>A0AAV6UZC2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_028667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000221">
        <property type="protein sequence ID" value="KAG8189128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZC2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF38">
        <property type="entry name" value="IONOTROPIC RECEPTOR 100A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8189128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="416" mass="47574" checksum="AAABC5463FE98CCD" modified="2024-11-27" version="1">MWGFPRQVRISAYPWVQCLRVNHTSEGPIFSDVDGKMFYYLVEALGFEYTVKFPEGKWGKMDANGTFNGVYGTLQRNESDIGIGCMAYFSEEANVAADHTFTYFLVHPTFLTERPGFIPKFGAFTYPFSTNVWISCLVTAIVAAIIFHKVLRRSQNDTIFHTFISVIGSMIQQPLKEGKDMRLLRGAWLAYTTLLVFFFTALLLTFLLLPVRERGVQTFEELSMAVQAGKMRSLIAKGSFLLKFIMKSKVPYMRILGETIHNKSWTYDYNERLEPLINKKTALFGFRSIFEFHFGDSLETSSVFMSKDTIGVWGASIAVRKSFCCKRMLNKVIGWAWAAGLPNKWFRDEVFLNNIKRMLATKYDDSVVPLTIEDLSGSFMILVSGYVLSIIVFVVEIWPKETIPVFVCKKSERKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V052</accession>
    <name>A0AAV6V052_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_008690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000192">
        <property type="protein sequence ID" value="KAG8190155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V052"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000022">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8190155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="261" mass="29297" checksum="5DCB6BA16532A730" modified="2024-11-27" version="1">MARRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILGSDGIVLAAERRNTNKLLDEVFNSEKIYKLHNDMACSVAGITSDANVLTNELRQIAQRYLIQYGESIPCERLVSWLCDLKQAYTQYGGKRPFGVSILYMGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSILKQEYKENETSLKDALALAVKVLSKTLDMTKLTADKLEMATLTRENGKTVIRIMPSSEVTVLIKKHEEEEAKIEAEKKEKEREKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0C9</accession>
    <name>A0AAV6V0C9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_019056</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000218">
        <property type="protein sequence ID" value="KAG8189296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="9">
        <location>
            <begin position="496"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP C-terminal head" evidence="10">
        <location>
            <begin position="1140"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8189296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1545" mass="178396" checksum="3F2843A1DE75B6FF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1P5</accession>
    <name>A0AAV6V1P5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sorting nexin-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_008104</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000203">
        <property type="protein sequence ID" value="KAG8189791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1P5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="6">
        <location>
            <begin position="110"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="398"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="605"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8189791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1079" mass="124529" checksum="4DB9CE2EAA288C59" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1Y7</accession>
    <name>A0AAV6V1Y7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phlebovirus glycoprotein G2 fusion domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000200">
        <property type="protein sequence ID" value="KAG8189896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1Y7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16170" checksum="0D66833C6BFD5452" modified="2024-11-27" version="1">MASAKQISICTTNGEDYHCGSAHRHLISKINLPPNACYVHDCSRCVTAIETYILTEDFKLIKPSHFILLNEPGVETKVENSIYECTSLEYEVCNIQTHNVSGTSDFCKRYKCVDSAKCQCHLTHEKRFYYTRTLTTGSKIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V462</accession>
    <name>A0AAV6V462_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Glutamate-gated chloride channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_008390</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000167">
        <property type="protein sequence ID" value="KAG8191076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V462"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="235"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8191076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="52373" checksum="9D24FFB186E29A87" modified="2024-11-27" version="1">MAQQQINTTEIPRFETETDKQILDKILDRKRYDSRVRPSNKTDVNVTVLILSLSSPDESSLKYEVEFLLHQSWDDPRLRYDDVGRYRYLNGMSHQERVWTPDIYFIKHGEFKAPLAQMHMALKIFNNGSVRYITRRNMILNCQGNLQIFPFDNPKCPFAIESVSHETYELELKWEREPGGVSGATSLRYHNAYLVQNKTGKCDSHHTWRGNYSCLRVLLVFTRDKIFYFSTVFGPGVVLVTSSFISFWLDINAVPARVMIGVTTMLNFCTTTNSFRSTLPVVSNLTAMNLWDGVCMFFIYASMLEFIIVNYLYRKYPHRSGAAAASSSAATTATDRGRWCGNFEIQQASVLKDNNSNDPGGISVDHSQQRRREEEDEADRRAAAALSIFGWLKRPQQAILPPNYNRQRLSKNIDKVSKILFPLSFGLFVAGYFLTYAVIKPTHSENWELLSNGYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4G9</accession>
    <name>A0AAV6V4G9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000171">
        <property type="protein sequence ID" value="KAG8190913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4G9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7861" checksum="D27838F0ACB472F9" modified="2024-11-27" version="1">MEMKLRSASDATMKTLCEMDFVPKRAMISLETIKHEIFLEDSCESSFRSIQKVPSLSDLSEENSLGKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4S5</accession>
    <name>A0AAV6V4S5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcium-activated chloride channel N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_008377</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000167">
        <property type="protein sequence ID" value="KAG8191063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4S5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013642">
        <property type="entry name" value="CLCA_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041940">
        <property type="entry name" value="choice_anch_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08434">
        <property type="entry name" value="CLCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043742332" description="Calcium-activated chloride channel N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="867"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium-activated chloride channel N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="966"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8191063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112762" checksum="01EC753BEBE1881D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4S8</accession>
    <name>A0AAV6V4S8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Neurexin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_024856</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the neurexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000175">
        <property type="protein sequence ID" value="KAG8190721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000015">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF91">
        <property type="entry name" value="NEUREXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043753493" description="Neurexin-4" evidence="12">
        <location>
            <begin position="23"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1271"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="129"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="14">
        <location>
            <begin position="241"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="14">
        <location>
            <begin position="424"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="589"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="14">
        <location>
            <begin position="842"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1014"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="14">
        <location>
            <begin position="1052"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1305"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1305"/>
            <end position="1314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8190721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1337" mass="151885" checksum="4EF79364A1F6A65D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5Y1</accession>
    <name>A0AAV6V5Y1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000148">
        <property type="protein sequence ID" value="KAG8191974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5Y1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="11245" checksum="0DEDBA1F91154795" modified="2024-11-27" version="1">MNINSRSYYWNAEALYDCYQLAGFTHQMTTSINRTNRLSTSITFTTDERVICNVPLAGSIVPKSSPMAIRAKFRGKSAILLRAAAIFQPNNIPIGECERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V621</accession>
    <name>A0AAV6V621_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000166">
        <property type="protein sequence ID" value="KAG8191116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V621"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="7155" checksum="830CC3657E53928D" modified="2024-11-27" version="1">MSFFTIAESGFDDVLSGKELTLQHSVPSCAVMTEVAVDELAPVTGAWNSGVVASLGPGTTGTNVLGMAGAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6J6</accession>
    <name>A0AAV6V6J6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_019604</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000158">
        <property type="protein sequence ID" value="KAG8191540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6J6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8191540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="307" mass="32726" checksum="7039D63917783EF0" modified="2024-11-27" version="1">MSSDPYSIPDPKVGSAGLEAMRRYMDSLPMDYTLREELTDQRFWKAVRTEFLATLLLTVLGCGSCIRFKAPPADVATAGAVELRVALAFGLAVATLVQCVGQVSGGHMNPAVTIALLVTRHISAARTACYVAAQCLGGIAGAGVLYGLTPPGQRPSAGLGATEPAEGVAASEAFGFEFLASVVVVITVLSNMDPRRTEMGCGALSIGFSYVVGHLLAFPYTGASFNPARSFGPAIVTNTWRLHWIYWVAPVLGGIIGGVTYDYTQESRSQPTLRRSFRKRPPSGINSRDMSALSNNETEMTVDHCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6P6</accession>
    <name>A0AAV6V6P6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_006130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6P6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000150">
        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF21">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043933257" description="Ig-like domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="836"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="535"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="634"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="727"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="876"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8191388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="947" mass="102760" checksum="8C526E391CCF6EBD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6X5</accession>
    <name>A0AAV6V6X5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="9">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_020727</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="9"/>
    <dbReference type="EMBL" id="JAFNEN010000159">
        <property type="protein sequence ID" value="KAG8191478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6X5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="10">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8191478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="152" mass="17163" checksum="4D84321E310B9196" modified="2024-11-27" version="1">MPRERTFIMIKPDGVQRNLVGKIIARFEEKGFKLVAMKFMQASQGLLETHYADLSSLPFFPKLVQYMQMGPVVPMVWEGDNIVKTGRDIIGATNPALSQPGTLRGDLCIQVGRNIIHGSDSVPSAEKEISLWFKDEELVDYKTALESWVYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8J5</accession>
    <name>A0AAV6V8J5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000132">
        <property type="protein sequence ID" value="KAG8193050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8J5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="123"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="237" mass="27289" checksum="9B94813395B6C384" modified="2024-11-27" version="1">MGSRRMTLRAREASRFTVLQWNAGGLSASKLAELREIIVEEEVDILIIQEANITEDNIKFYQIRDFTMYGLFKKRKVASSILVAIRNKFTPSFEVVKEMNEHDLSEIAVVNIWIWKTQLRESFNAMSPNWGYKNRNQAGQTVEDFIDSNAMALMYNTKDPKTFIHNSGNSTNPDLTMVSTNIVDQCTKIVIGDPGSGHRITKLIFESITKLKRDVPRLMWNFKKAKEGKSLHRLERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V943</accession>
    <name>A0AAV6V943_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gastric intrinsic factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_027789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000144">
        <property type="protein sequence ID" value="KAG8192146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V943"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015889">
        <property type="term" value="P:cobalamin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002157">
        <property type="entry name" value="Cbl-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051588">
        <property type="entry name" value="Cobalamin_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559:SF18">
        <property type="entry name" value="TRANSCOBALAMIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559">
        <property type="entry name" value="TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01122">
        <property type="entry name" value="Cobalamin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="163"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8192146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="49875" checksum="7C885093505A6076" modified="2024-11-27" version="1">MYFEREEYNGLIIAEPRTAPNAHNWRSNFSLTYKIEEGFFPVKFDNGVLDSGVSWLRNQSSDIMGWKVNTPRAVVALFLASAVNFDGNVSDEELMANQVELKTAVALMKSTTSITELSMLVNALLVTCYNPRMFHGTDVVQRLKSLVTRSRDVVHPVAYLALCNANETWPDRAAGDLDAVLNTTSNPQANQDMKAMAVMALSCYLYHRDYVLPSDQSNTTELLFDDTIKHFKALQFRDGSFGNVYTTALIAQALIADRDIYWNINKTAKYLINKLNSTSNFLTAYLVLPFLNGKSLVDVSYTNCSAHPRKHSDEIEDNKEVVTPIMQVKYSLFYGDKKHVIQSMYLGVPENSTAYYIMEQAEIDNPKYYTFERKNITGSINVFEMSGIPNDPENGNYWMMFVSPPKRPEIITYTDKSPDDLIMKDAQHLVMWYKGHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAW5</accession>
    <name>A0AAV6VAW5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000131">
        <property type="protein sequence ID" value="KAG8193085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAW5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9318" checksum="F2DB4808042B1853" modified="2024-11-27" version="1">MSGPRTQQELRTSTLYRNTPAADDTSHGTPVGGMAKRERCPRARERMFVSDDPLRSSDGLGMGCLFAQENMENTSLSLQGTKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBJ3</accession>
    <name>A0AAV6VBJ3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Receptor-type tyrosine-protein phosphatase N2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_000968</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000108">
        <property type="protein sequence ID" value="KAG8194130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBJ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051046">
        <property type="term" value="P:regulation of secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000017">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase-like N isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033522">
        <property type="entry name" value="IA-2/IA-2_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106:SF4">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="191"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="370"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8194130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="52508" checksum="58DB532E4558BA46" modified="2024-11-27" version="1">MNAWRLRALLNRAMPHAKLITRWGEKGSYRYIPVIYVEWYGTAYTSCIDHVKYEAVKPNHDRRLIILTFALCGAVAGILLAAITAYFVRRHALSRDKVQDIAQPDTEASQDYQDLCRQRMAAKANEKPEPAHTTHSPKKIRSLSQEGPASTSSHSSTSSWNEEPVTSNMDISTGHMILSYMEDHLKNKNRLDREWEALCAYEAELCSTLAATQPQNVKKNRYTDVVPYDHSRVVLNELSNVSGSDYINSSSITDHDPRNPAYIATQGPLPQTAADFWQMVWEQGSVVIVMLSRLMENGVAMCHRYWPEEGSEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFMSWPDNGVPNSTKALLEFRRKVNKSYRGRSCPIVVHCSDGIGRTGTYCLIDMVLNRMAKGTKEIDIAATLEHVRDQRAGMVKTKAQFEFVLMAIAEEVHAILKALSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCA6</accession>
    <name>A0AAV6VCA6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEHE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_003780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000125">
        <property type="protein sequence ID" value="KAG8193293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035035">
        <property type="term" value="F:histone acetyltransferase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026180">
        <property type="entry name" value="NSL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029332">
        <property type="entry name" value="PEHE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22443">
        <property type="entry name" value="NON-SPECIFIC LETHAL 1, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22443:SF18">
        <property type="entry name" value="NON-SPECIFIC LETHAL 1, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01300">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEHE" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1259"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1312" mass="144250" checksum="C2FA495CCF684993" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VD59</accession>
    <name>A0AAV6VD59_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000112">
        <property type="protein sequence ID" value="KAG8193973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VD59"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="213" mass="22827" checksum="6181EB6AFEE82782" modified="2024-11-27" version="1">MTTLLLVTLATAQVPPRPGGSGGGGAVTPGGVEGNIRPQVQLPVGPSNAPVGPSNAIVVVPSNVLDESASADGNFVPGQIRGDRLSGTTGGPYRRRGDHWHGSSGGSFFRHTGPPTIFHKFPSCQDIDMDIRETYKEMWRHRQIGPTVNRCKVQNIQECMYKDMNAARCNARTKPTEQCIQEVMSYVRGTNCGSQATTTDVTPMNDTTLTTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VD62</accession>
    <name>A0AAV6VD62_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="9">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_013225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VD62"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000066">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase SSU72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8194467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="193" mass="22425" checksum="5687F660202C19FD" modified="2024-11-27" version="1">MNELRVAVVCSSNQNRSMEAHAFLSKKGFKVRSFGSGNQVKLPGPAPDKPNVYDFNISYEQMYQDLLTKDKSLYTQNGLLHMLDRNRRIKSHPERFQDCYEIFDVIFTAEERVYDQVLEELTSRSPKDINTVHIINIDVQDNHEEATIGAFLICEMATMMAESDDLDNDIDELLQEFEFKAQRPILHSFLFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIE7</accession>
    <name>A0AAV6VIE7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-latrotoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_002640</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Homotetramer in membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cationic peptide 01 (latrotoxin) family. 03 (alpha-latrotoxin) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000087">
        <property type="protein sequence ID" value="KAG8195468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIE7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="12" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="482"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8195468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="827" mass="92130" checksum="8DD53BD272797D9E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJ82</accession>
    <name>A0AAV6VJ82_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_028951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000075">
        <property type="protein sequence ID" value="KAG8195977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJ82"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056358">
        <property type="entry name" value="APC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23405">
        <property type="entry name" value="WD40_APC4_C-half"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="6">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="7">
        <location>
            <begin position="236"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 C-terminal half WD40" evidence="8">
        <location>
            <begin position="601"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8195977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="735" mass="84238" checksum="8FFF33C278ECA18E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VL21</accession>
    <name>A0AAV6VL21_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000058">
        <property type="protein sequence ID" value="KAG8197185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VL21"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="360" mass="42839" checksum="16C497C258858F5C" modified="2024-11-27" version="1">MKGSVSKYVSSKHPNKMKVIVVDDKGPGHHHRHYFHHYPEGANEHSQSHGYNDENAQSRNNNYNHGYADQHNKNKDYLNNFENSELFFEKRPTTENTQVYREKHKRNKNFMFNFNYEFRDQQFKTQKDYIENLDKDKEFYRHKPTNENPKLPKRQNPAHENTREFDHKQNRYKNIRNLHFNDNQESNRNNRLLSGHKPINNHTREKPANYNSLNEQDSFKNTFNENHQQYEAKRPSSNYEFDDFELKYGMDIAHDSNFGKRLRNPDSKYRPNNEKSSTSHQGSAKNEAVKFSTGVNETPVHKGFLFERIPTSTQYDNGPFYREVNNFRKKNENNSINVFKNVNLIPLNGFKVSIPTLGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VL36</accession>
    <name>A0AAV6VL36_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_014507</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000064">
        <property type="protein sequence ID" value="KAG8196775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VL36"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="146"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8196775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="264" mass="26375" checksum="1FB5FEAE31883318" modified="2024-11-27" version="1">MSRGFGGGGRGRGFGGGRGRGGGGGFGGRGGRGGRGGFRNFDTGPPDQVKELGYFTHPCEDDLVCKVTIDDVPFFNAPIYLENKQQIGKIDEIFGPMRDYFVSVKLSDDVKANSFEPNQKIFIDPAKLLPFTRFLPKPPGTPATPGRGGRGGRGGRGGRGGGGGFGGRGGGGGRGGFGGGRGGRGGFGGGGRGGFGDRGGGRGGFGGRGGGGFGDRGGRGGFGGRGGGGFNNRDGGGGYNGGGGGFKRNFDGGDSGQNKRQKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLC2</accession>
    <name>A0AAV6VLC2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_004281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000059">
        <property type="protein sequence ID" value="KAG8197008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLC2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8197008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="121" mass="14053" checksum="635D0BB77A86CE1D" modified="2024-11-27" version="1">MGRKKKKLSKPWCWYCNREFDDEQILIQHQKAKHFKCSICHKKLFTGPGLAIHCMQVHKETIDKVPHALPHRNSIDIEIYGIEGIPEQDLIQHEKQGSYNGNSDGNPHNTDSRTDKMAINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM01</accession>
    <name>A0AAV6VM01_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="8">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_020095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="8"/>
    <dbReference type="EMBL" id="JAFNEN010000049">
        <property type="protein sequence ID" value="KAG8197817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="9">
        <location>
            <begin position="387"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP C-terminal head" evidence="10">
        <location>
            <begin position="970"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8197817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1372" mass="158793" checksum="5494EE88A8D9F6FC" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNZ6</accession>
    <name>A0AAV6VNZ6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_015302</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000042">
        <property type="protein sequence ID" value="KAG8198205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNZ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000117">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase makorin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="227"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8198205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="427" mass="49004" checksum="D08BB7FD5FCB0B17" modified="2024-11-27" version="1">MAEGNSYVPDTTVHAFSTHSSSSERDRSSALPRESTRPKQPCRYFQQGRCVFGDKCWNSHVAVAATVRTDDPPAQRSERSAGPSRQQLLENTPPTEPTRRYESRFSTLHKKSAKPKASHHPPNWVDAPEFVPKTTRSYADTLKTHRGMAVYNENVALELCSYFMDGECPFEYGCPYLHGEVCDICQKACLHPFDARQRQQHVELCEKELEQDMELSFAVARSRDKACGICMDVILDKEPLSERRFGILEKCNHVFCLACIRKWRKVKSFESTSTYVENVLDPEVTRACPECRVASDFITPSQFWVDNEEEKEKLIADYKVALSKKDCKYFKQGKGSCPFGGACFYLHAKPDGTKVELPPPRRRQNQVGELDFFNSILLWDYLELRESNVFMQLELNGYTYPDELGTDTSEDEDNPRETPYRPEIFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQ75</accession>
    <name>A0AAV6VQ75_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000033">
        <property type="protein sequence ID" value="KAG8198957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQ75"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043978211" evidence="1">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8574" checksum="0C41107807B71A45" modified="2024-11-27" version="1">MQAFKLLAFAFVLLMLAVSRGDDASVDKPKDDKKVEIPPWWPSVMEEGKTSKRSPKEWYEWIYDNPITRLTSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQE9</accession>
    <name>A0AAV6VQE9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009313</name>
        <name evidence="3" type="ORF">JTE90_023496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002400">
        <property type="protein sequence ID" value="KAG8172771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010000036">
        <property type="protein sequence ID" value="KAG8198730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQE9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8198730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25504" checksum="1915F2E938237A3B" modified="2024-11-27" version="1">MKQPVSRNEFRKSQSNFHVTNNKCIFCNMPNHRIYKCFKFLNLTVPARKAFVHENSLCENCLRCHPNTSCTSSKCRKCNKDHHSLLHEEPEVQNATSAKGINQAEVTSHLSRNPPTRLITLMPTAVIQVLDGYGQRQPCRALLDSASQTSFVSERCVQRLGLHRKRVNIRIYGLTTSTVGTARGKDHSYFRPVSSNNSGSSLPAVSSDESLANAQLAYVNEDNRLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRK2</accession>
    <name>A0AAV6VRK2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein PTHB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_015519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000037">
        <property type="protein sequence ID" value="KAG8198696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRK2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028074">
        <property type="entry name" value="PHTB1_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028073">
        <property type="entry name" value="PHTB1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026511">
        <property type="entry name" value="PTHB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055364">
        <property type="entry name" value="PTHB1_CtH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055363">
        <property type="entry name" value="PTHB1_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055362">
        <property type="entry name" value="PTHB1_pf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991">
        <property type="entry name" value="PARATHYROID HORMONE-RESPONSIVE B1 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991:SF0">
        <property type="entry name" value="PROTEIN PTHB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14727">
        <property type="entry name" value="PHTB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23339">
        <property type="entry name" value="PTHB1_CtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14728">
        <property type="entry name" value="PTHB1_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23338">
        <property type="entry name" value="PTHB1_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23337">
        <property type="entry name" value="PTHB1_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTHB1 N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 GAE" evidence="3">
        <location>
            <begin position="437"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 platform" evidence="4">
        <location>
            <begin position="523"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 hairpin" evidence="5">
        <location>
            <begin position="633"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 C-terminal helix bundle" evidence="6">
        <location>
            <begin position="738"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8198696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="930" mass="104006" checksum="CB67A385F3FE70EF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSK5</accession>
    <name>A0AAV6VSK5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000032">
        <property type="protein sequence ID" value="KAG8199041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSK5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="112" mass="13243" checksum="C6C2845AA08AB84F" modified="2024-11-27" version="1">MAYVTKMTSHSLPQRYRHSHSMQYLHPNYNPQVRYRRNNTWEMMYRGCGSMWASDASLTLASQRFYTKKIRNQHHHPKPNGRNSKNFPPFKKAHLRTSPHLATSLRGIFKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTF4</accession>
    <name>A0AAV6VTF4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_006182</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="12"/>
    <dbReference type="EMBL" id="JAFNEN010000022">
        <property type="protein sequence ID" value="KAG8199935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTF4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000109">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000157">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000686">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="18"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="290"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="394"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="712"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="787"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="746"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="791"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="818"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="24"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="400"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8199935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="859" mass="96395" checksum="68E5EAD6C63F3893" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUZ6</accession>
    <name>A0AAV6VUZ6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000023">
        <property type="protein sequence ID" value="KAG8199911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUZ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="168" mass="18122" checksum="45ACF11E8F1238EF" modified="2024-11-27" version="1">MKSKKKRVLSTFDSRISAFLQILAPALPGGSMIETVSLHTIYLGLKEAAMKTLFIQLIIGCLLIDLVFAQQLELTLKKKALIKTARKIALGKDKKFIKYGLGAATKGTKGAVQGIIGKPVKLVGVLLGPLGIPLKLIGTVLETKSVLNKAKAVVYTVKKFSRDSVRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWE5</accession>
    <name>A0AAV6VWE5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWE5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="9900" checksum="82E0E85A2EBA7DAA" modified="2024-11-27" version="1">MLSISSIAPLLGIRNNSKSSSRHPKHRGSQSKHNRHRETLQSPQSSRCQAGETTPEADTFLTPIQAFSDPTFVVALMNGLRMTEVTMHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWX1</accession>
    <name>A0AAV6VWX1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_028824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000008">
        <property type="protein sequence ID" value="KAG8201165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWX1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042327">
        <property type="term" value="P:positive regulation of phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18318">
        <property type="entry name" value="BTB_POZ_KCTD20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039886">
        <property type="entry name" value="BTBD10/KCTD20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039885">
        <property type="entry name" value="BTBD10/KCTD20_BTB/POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637:SF0">
        <property type="entry name" value="AT10158P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16017">
        <property type="entry name" value="BTB_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="179"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8201165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="497" mass="55293" checksum="7F2E58F5FF8383B8" modified="2024-11-27" version="1">MKYKERKDNESKLRLRINLGKAFRKIPTTTMSGRKDRSKGSQKSNNSYENSSSDAEESENNEDRRGRKGGCGYSNSPKLKPCLVSRMGDQVESSPSSSGSSRDSPPLTAGPLHMTFTTAPGTKNIQRTHQLSQHSSVARNHSLEHCCSGYTNGDACNQPAVTNTSSANQLVVVPAASDERITLVVENTRIIVDPALFAAHPDTMLGRMFGSSLENNFTRPNERGEYEVADGISAIVFRAIMDYYKVGVVHCPPSVTVPELRDACDYLLIPFDANTVRCHNLRGFLHELSNQGARQQFEKFLEELILPVMVESAQRGDRECHIVVLLDDDTVDWDMDYPPQMGEEYSQIIYSTATYRFFKYIENRDVAKQVLKERGLKKIRLGIEGYPTYKEKVKCRPGGRSEVIYNYVQRPFLRMSWEKEEAKSRHVDFQCVKSKSITNLAAAAADGALDAAAPANITPGTVEGAVGGHLEEEGVVIPPHPSPRELYPDQLPPEDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYE5</accession>
    <name>A0AAV6VYE5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_028751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the canopy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000008">
        <property type="protein sequence ID" value="KAG8201080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYE5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042415">
        <property type="entry name" value="CNPY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13341">
        <property type="entry name" value="MIR-INTERACTING SAPOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13341:SF2">
        <property type="entry name" value="PROTEIN SEELE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043652916" description="Saposin B-type domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8201080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="178" mass="20536" checksum="57FA4C92B25EA6C2" modified="2024-11-27" version="1">MNRTVHFWIFAFIFLTFFQSAFQQSIVKCLVCKQVVNEINNAVTNEDPKKKIQVGSFRIQPDGSQKQTQIKYAGSELHLNEILENVCNQMDDYAQAKSKDSGELTLLNLSKDVEKLSTHELVQDPDLNRGLKYYCENFIEEYEDEIISIFKKDSLDYDLERKLCSEAAGYCVAARNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYS3</accession>
    <name>A0AAV6VYS3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYS3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="10769" checksum="23D5F3FBF1249DFD" modified="2024-11-27" version="1">MKRSLEKCEWTTLTLKYSIDLLSLSPRTELRRTLRINNRAGHRKEDQFSAFWTEEVHRSQDPSKCFVRGGTTGWRKYNTRELCQMMSLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZ79</accession>
    <name>A0AAV6VZ79_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_015766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000012">
        <property type="protein sequence ID" value="KAG8200861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZ79"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="3">
        <location>
            <begin position="63"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8200861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="150" mass="16715" checksum="54488C356E5614B3" modified="2024-11-27" version="1">MQRPNHPVTRRDLFRSTKVCDEIELKERASRSLLPSDDPIDDMNRPHSSASTSSAVALRSTPARGYTNVLMGGANPMVYTCMHADSELREILKEIRVITAKMRQDDEDANVVSDWQFAAMVVDRICLFSFTIFTIASTVLSLGSAPHLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZD7</accession>
    <name>A0AAV6VZD7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000009">
        <property type="protein sequence ID" value="KAG8201078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZD7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="10450" checksum="1C9E51D782968852" modified="2024-11-27" version="1" fragment="single">PLLKESLHQENKHHGEATGLHRNVNLKRKQVWNMFWRMKICLYIASFSYPYENKENCIVRAEHISTFKRSPCHFRIYAKGFPWKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDD0</accession>
    <name>A0AAV6TDD0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of rDNA transcription protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006608">
        <property type="protein sequence ID" value="KAG8155778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDD0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12044" checksum="E53F10F40628A115" modified="2024-11-27" version="1">MIGRADIKGSKSNVAMNAWLPRASYPCGNSSDTSCIKLVKSKGSIGPAFAVRIHTENQDQASFCPFALREVSVLAELALGHLRYHLTDVPPQPNNPPESVLGADRALQGGSALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDW6</accession>
    <name>A0AAV6TDW6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006277">
        <property type="protein sequence ID" value="KAG8156146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDW6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8156146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7726" checksum="389D6426F77A5393" modified="2024-11-27" version="1">MVRLFLLGPLDPDLTIVLCTSEPLCGPPPVFLWPRPCPASSPSFFCPNVCAQTPPLPQVNALVSRVRPARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFW5</accession>
    <name>A0AAV6TFW5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_025901</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004978">
        <property type="protein sequence ID" value="KAG8170727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFW5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="93"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8170727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="217" mass="25074" checksum="C525699A94C40650" modified="2024-11-27" version="1" fragment="single">MSTNCSSCREVITEASDCISCKVCKNTLHFYCCGFREANFRKTSKETKNSWTCDECKSSKTSTAADSNKSFQKEILDQLQEFKRSLDFNSKVLEEVVKSNKNLQEELQNIKKENYQLIEENKQLKTQIAEIKNDVIDLQQYSRRLNVEIANLPECENENITSIMESLMVALETDQMKDLVTYHRVPTISKTKIKPIVVQFTSITTKNNFLKIAKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGQ5</accession>
    <name>A0AAV6TGQ5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004554">
        <property type="protein sequence ID" value="KAG8171030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGQ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9393" checksum="81FB9D929F556CCC" modified="2024-11-27" version="1">MGTDRHENYTISLDFQGAQKRRTGPAKTRGFYGTASLSPDEPIPGTELLQRKNNFPRGPRRRLRFGCVTALVPKDLSPCPVGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THR8</accession>
    <name>A0AAV6THR8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004084">
        <property type="protein sequence ID" value="KAG8171368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THR8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9688" checksum="21EA9743A39FF9DE" modified="2024-11-27" version="1">MIHPRFTDGYLVTTFISPLNNQVRHLFGTSARPESQIDSQSEVLTKIFNRFANHTSPGTQKLLVFPGKLPGVSFEEHSRSLAGIVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLG3</accession>
    <name>A0AAV6TLG3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002745">
        <property type="protein sequence ID" value="KAG8172406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLG3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="116" mass="13723" checksum="D22A327CF29466D4" modified="2024-11-27" version="1">MVVGKKYSRYYVLVNFHEEKKFSVLRLKDAVPDCLNFSDSYDINKWDRSTEVETKWENETYPAYFIQFGENKRMMDDLIDQIVVSGDTSNLPLLQTENEGKRQKKRKRAEMAGPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TM20</accession>
    <name>A0AAV6TM20_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002141">
        <property type="protein sequence ID" value="KAG8173022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TM20"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="27521" checksum="15F7AE2E5EC1DD21" modified="2024-11-27" version="1">MKYDKERYEVGLLFKGEVDLPDNFEVLKRRLNSLVSRFRRDPVLYENYKSVFEEQFMSGVIEQVDIIKDDLVDRIYYAPHHPVIREQKESNRTRLRIVFDMSSKERGPLSLKDNLHSGPNLNPNLLTLLLKFRMNRIRIVADIERAFLSIGLKEVDRYCQRFLWIDKIPPTEIMVYRNTTVSFGIKSSPFHLAATIKHHVRTFENSNPAAYKALNDCLYLDDLIISLNDIILND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TN30</accession>
    <name>A0AAV6TN30_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002153">
        <property type="protein sequence ID" value="KAG8173013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TN30"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="491"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="693" mass="81977" checksum="6B1CB219FAE8154B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNL6</accession>
    <name>A0AAV6TNL6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002073">
        <property type="protein sequence ID" value="KAG8173086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNL6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="12307" checksum="46DCCC14B9CB2768" modified="2024-11-27" version="1">MVGRRYARDKNGNEIYPRRRHTLFSRNEEGQEYYARDKNGNEFYPCLNGQSVVIPERLAKFANNTQRYPSDAKGNEYYLQHQGKPYLLRQESGGNVLGQTRKGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPJ8</accession>
    <name>A0AAV6TPJ8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001470">
        <property type="protein sequence ID" value="KAG8173824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPJ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043910800" evidence="1">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="176" mass="21154" checksum="E632B5B5E9ACC33A" modified="2024-11-27" version="1">MTGRWIFLLLILLTLGLTAYMMYMTTHNDEHLKDVGEWIENALLKTYDQLRKLTGYSTMLNKVQSMGQLSSEEIMRRTYVGLEQYLQSLLDSTSYQEYLQQKNIIFPTWQHIWEKCEAWLRKHTFHNMSDTIMDLAHIIPNMDNYRYQLQNALHMHEPFWKQVYNNLVIAKKRLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPY4</accession>
    <name>A0AAV6TPY4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001510">
        <property type="protein sequence ID" value="KAG8173751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPY4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="275" mass="29711" checksum="721B6F8BA34F148B" modified="2024-11-27" version="1">MASSSGILPGRPFRASFTSLQPFEASVGLSQVPDGSWTALYEISLMPLLEQVLPCLCVRPDISAFWINGREPIDFALVCLLSGGCAAFRGDPPPLLNNSQRVHFRLSSPWPPPVASSTRGKTVPCAPPPKCHNVPHPRCRYVPHQSPHLPVSFRRFGDPEPPSDLVLVPGTPAASTPPGPKNSPSSHPLDENWSLVFSPSLSKRAIYSRTETSRAMASSETKPDPAPSLETLEPLTTPPPYLRPPPPGATRCGARCFARPRPAPSRHLSTLWGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSQ7</accession>
    <name>A0AAV6TSQ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phage related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001166">
        <property type="protein sequence ID" value="KAG8174658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSQ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13481">
        <property type="entry name" value="AAA_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="30557" checksum="66CC2900472E0467" modified="2024-11-27" version="1">MLQDFLTTGQKIPFFSVKEYLSDKAPIPEDIIYPRILTPRGLLVFGGPPKIGKSDFLISWLMHMAAGVSFLGMIPNQPMKVLCLQTEIDDGYLKERLQELKLDKEFLDVGANNFMITPRVQLSLSSEEIDEIKNSLEDKCFKPNILAIDPLRNIFSSEYGNENDNSAMLFFLQKTLERLRNAINPDAGIILTHHTKKLSKKMLEEDPFQGLSGAGSLRGFYTTGMVMFSQDEGSTVRQIVFELRNGERVPSKLVDKINGHWQLINQWNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTB3</accession>
    <name>A0AAV6TTB3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001118">
        <property type="protein sequence ID" value="KAG8174899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTB3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="720" mass="83063" checksum="029324D88A704DFF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUI3</accession>
    <name>A0AAV6TUI3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001034">
        <property type="protein sequence ID" value="KAG8175301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUI3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="165" mass="18203" checksum="9CFFCDD288C54289" modified="2024-11-27" version="1">MSHSDTETDLATDMTASSIGGKYALRPSALSNLADYGRLGDTELDNVDKVINYVVNDTEMSNDNTNVDLIKNAKDSEFASKDMNKNSLNSNFTNHDMINDKMSHLNSDGNSATPAFRREGFLVRMVLLMAFLEETKSRLMIYLVIVLPSTGRNSAILISVTKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVP2</accession>
    <name>A0AAV6TVP2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000953">
        <property type="protein sequence ID" value="KAG8175738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVP2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="750" mass="85140" checksum="C7F2CE69545CE107" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXH4</accession>
    <name>A0AAV6TXH4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000914">
        <property type="protein sequence ID" value="KAG8176177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXH4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="555" mass="64869" checksum="3FB80E628C0BE37D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXU4</accession>
    <name>A0AAV6TXU4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_025548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000918">
        <property type="protein sequence ID" value="KAG8176090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXU4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8176090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46442" checksum="4595BF2CFEB86AAF" modified="2024-11-27" version="1">MLPDLASPAVSMRPYLTSPLLSLKPSPTCLSDAFSRISAIHVVQPSLPLVEPLVQPSRPRGAPSPAQPNRPREEPLVQSSRPREEPLVQPQGGPAVRCSPHPGFEQKQTCPQNLLGSVPVNLASAHGLTLTSSFCSKIDSALFDDDRNSLLPNKRGEKREWSNAKKKEKPRPKTFYKLQRAISGTSEIRHRASKTRPRRKEEKYDKRLQYYIGGGIAINENTDNPIPIPPPAPSTSKAKQSPLDFFVEGGKPISKGKADKLDKQLIRLIVKEYNPFSIVEDKEFINFVKLLCPTYKLPYRKTISNGLLNATYNDAVDECRKVLDKVRNVSLTTDGWTFINNESFIATTVHFIDEDGDLKSLLLGCSRFEASHTSVNLGEDLKSNLQLKGLEGKVVCVTTDTRSHSDGSAKWVVLPTVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYI8</accession>
    <name>A0AAV6TYI8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_020161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000888">
        <property type="protein sequence ID" value="KAG8176375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYI8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14366">
        <property type="entry name" value="CUE_CUED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040195">
        <property type="entry name" value="CUE_CUED1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040192">
        <property type="entry name" value="CUEDC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13467">
        <property type="entry name" value="CUE DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13467:SF3">
        <property type="entry name" value="CUE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="65"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="458" mass="51246" checksum="FAD87F9185A31CC2" modified="2024-11-27" version="1">MVKLNKENNEQSFNLEIQQKQTADPHLSYNVTTIFFDRKDNSRAMAEVDQEEPPSQERPPVTQLEFRQAMRDFKTMFPEMDEDVIEVVLRSNNGAVDSTIDQLLTMSTDNENERLRTELDATENDELPPCYSPSTPPPSYHQAVPNFAAGDNSAAGGNIAAAKAEGESQAARSPKVQFTLPEETVSRLPDIVENGEASLARRRSDAMAAASNSSSEEGACGTDVALKVLNNWKPPLLGELPPNFLKVNGMPGVKLGPKKVTILSSTILQQRIEENERKRHDGTSTNDPELTQYLEDERIALFLQNEEFFQELKDNKEFLSTLERASAELSSPEEEEEGEEAEGGAEEVDPNFPYSNDVQPEETDAAFREKIKNMGKVSRKKFTQLAKLFSRRKRRSFKPILGDGSNPSRDNLLLHEDEYSELSEDDSENEVNKKDTWNSHVGGPGGRSQTIERSKMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZ85</accession>
    <name>A0AAV6TZ85_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_015740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000822">
        <property type="protein sequence ID" value="KAG8177089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZ85"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="493"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8177089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="86664" checksum="2622B00A3E615285" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZW9</accession>
    <name>A0AAV6TZW9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_012649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000817">
        <property type="protein sequence ID" value="KAG8177123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZW9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043585789" description="SEA domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="4">
        <location>
            <begin position="846"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8177123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1139" mass="124196" checksum="DDA1BCB43FAADD12" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4I8</accession>
    <name>A0AAV6U4I8_9ARAC</name>
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        <recommendedName>
            <fullName evidence="7">TBC domain-containing protein kinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_011971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000653">
        <property type="protein sequence ID" value="KAG8179024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4I8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000015">
        <property type="entry name" value="TBC domain-containing protein kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000012">
        <property type="entry name" value="TBC domain-containing protein kinase-like protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF168">
        <property type="entry name" value="TBC DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="466"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="780"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8179024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="880" mass="100541" checksum="725E832442BDFFCC" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4Z7</accession>
    <name>A0AAV6U4Z7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neurogenic mastermind-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_015338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mastermind family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000646">
        <property type="protein sequence ID" value="KAG8179149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4Z7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046370">
        <property type="entry name" value="MAML_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019082">
        <property type="entry name" value="Mastermind-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09596">
        <property type="entry name" value="MamL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01275">
        <property type="entry name" value="MamL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurogenic mastermind-like N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="414"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8179149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="896" mass="100291" checksum="9518B3661F91BD64" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6W2</accession>
    <name>A0AAV6U6W2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_017426</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000598">
        <property type="protein sequence ID" value="KAG8179894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6W2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016447">
        <property type="entry name" value="Translocation_assoc_membrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12371:SF11">
        <property type="entry name" value="TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12371">
        <property type="entry name" value="TRANSLOCATION ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005449">
        <property type="entry name" value="Translocation_assoc_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="11">
        <location>
            <begin position="114"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="335"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8179894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="393" mass="45046" checksum="5140C4AA8C4C0C51" modified="2024-11-27" version="1">MGLKRRTGTKNPPIFSSEFLIQNHADIVSCIAMLFVIGLLFQVSAPLASVFVVMHHNVTEALDPSVPVLYEGGRQDVCVVTFYFLIAIVMHAILQEYALDKLNRKLHLSKMKHSKFNESGQLLVFYLISLLWGGDIILRDGYLLNISKLWQDYPHNEMTFMFKFYFIVQFAYWLHCYPELYFQKVKKDEMKPRIIYTTLYLAFLSAAYVLNFSRIAICLSVLHYLVESVFHTARLLYFAEKNKAATYGFTVWNVVFVVARLASITLSVLTFWYGLAQGEKEAVDWAQGNFNTKVVRVNCVVGVCLLQAWMMWNFINFHLRRMRERAAAAASSRKKALAKKEKKAASRKDEQLKQKSEDEVNELPEVDQNTKKAGGGELRSRVGAAASPKAKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7Y2</accession>
    <name>A0AAV6U7Y2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000606">
        <property type="protein sequence ID" value="KAG8179726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7Y2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="284" mass="31915" checksum="AE8D2C4AC2092D04" modified="2024-11-27" version="1">MGNIEGVTSTGMKITLKDVLFVPKINGQLISVKSIESAGYTLTFKNEKVYASKNGGNRSSNRITVSRNVTFNEKKNSISSPSLITTQNIEDSSESESEQADAPEHTADPIVPPESETRRSTRTRKPVVKFPHPEVYAATNAEETFSYKELCERPTAEQRPWRKAMKEEINSMNENQVWELQHPPPGVKPITSKWIYKKKRDDYNTNERTIPDREESFVLYDLWAQLPSATTEKNGIPSVTSPLSIASCFSSVAVSFIDFKAAISQASYTILAVCILGHRRKVHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U819</accession>
    <name>A0AAV6U819_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_002004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000562">
        <property type="protein sequence ID" value="KAG8180472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U819"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028197">
        <property type="entry name" value="Syntaphilin/Syntabulin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15290">
        <property type="entry name" value="Syntaphilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="411"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8180472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="547" mass="62180" checksum="0C404E2D290A9C46" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8V3</accession>
    <name>A0AAV6U8V3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000569">
        <property type="protein sequence ID" value="KAG8180298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8V3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8353" checksum="A1E6DAD8DB93D54D" modified="2024-11-27" version="1">MSLEFQRKLYPYTSTNPTSEANFRKELAKRNPQETRGSITQLPATPSAFRRVFTADTFSHKSSIFITDLIGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAD6</accession>
    <name>A0AAV6UAD6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein axonemal assembly factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_013169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cilium-specific protein required for cilia structures.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000528">
        <property type="protein sequence ID" value="KAG8181199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAD6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF8">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8181199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="830" mass="92653" checksum="141347B8568D7FAA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAQ9</accession>
    <name>A0AAV6UAQ9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_018253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000559">
        <property type="protein sequence ID" value="KAG8180635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAQ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8180635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="201" mass="23439" checksum="A6598157443B3AF0" modified="2024-11-27" version="1">MRVYLGKDKDECIPGKGVVVLKLMDEVRGKGHNLFMDNSFTSPKLFIELSDNSKINCCGTVKKNRQDMPQNIKPKKKSEMNALWSKALMSVCWKDKRDVYVLSSMHKPTNATLDVSEEVKKLGIINSYNKNMGFVDLSDRMANPYGFSRKTMKWPKKLFFHFVNIAVLNAYIWFKMKRKIKREKQHQTIRSIKNQSLNFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UB03</accession>
    <name>A0AAV6UB03_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_014252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000509">
        <property type="protein sequence ID" value="KAG8181522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UB03"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010312">
        <property type="term" value="P:detoxification of zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF9">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="50"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8181522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="454" mass="50120" checksum="96EAEF6431B7CB36" modified="2024-11-27" version="1">MSQFIEPTSKLICRLDTWHAKCGLEFLEYLKGTLVKISPAMRSSVLYSLIALSGMVFGAEIVASHVTQSLVLLISAYHMLYNILSLLLLVISHRMSKGKTLKNTFGWARVKVVGLLINMLFLVALCFAACVEAVQTMVHASHEDTEPRYPHIMVALGALNLALNVLCFILIGGYTHHQGCSMIIQSEDIQMSCVLSEEVKSSNTQSALGIPTSIKYSSNSTGSNKGCWDHQILDISRDISSCLTVIACGSVILLMEGLILKYADSILAIASIIVLLSTTYPFVRESGLILLQSIPNHIDVEGLTKRLIAEFPDLLQVHDLHVWRLASSVVIATVHVILPSPEMYTRIDSRLNQFFLTEGISSVTIQPEFTNGNWPEKEKSECILHCSLSNNCGALTCCGHLVDKSKNGIRCRSSHHRADATDKQQMKNIEAETDIPLLPQYDFSKFVSAHETTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UC47</accession>
    <name>A0AAV6UC47_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000487">
        <property type="protein sequence ID" value="KAG8181935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UC47"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="213" mass="23134" checksum="9BFFDEE03BC8C019" modified="2024-11-27" version="1">MSTLDLVVKAIEIIGAPRRGASYLAIQKWISSSRGNVTINRLKADLKKAIEKGLKSGILKRPTISKNVTGLRGYFILNKDVIALNKMKDKMKQDEVEIAEKLEEKAQVTKVEETKTVNVKKTKAAAIKKTKAAAIKKTKAAAIKKTEAAAVKKTKAAAVKKTKAAAIQAPDSAPAQGLDTDEMEWRFKLFLLMCAMEMAKSNDSGQGSSSNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCN2</accession>
    <name>A0AAV6UCN2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_000050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000487">
        <property type="protein sequence ID" value="KAG8181939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCN2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="386" mass="42046" checksum="AFBC535A832558AE" modified="2024-11-27" version="1">MEAIQTIGVPRKGASYLAIQKWIASSKENVMINRLKANLKKAIVKALESGLLKRPAISKNVTGLRGYFILNKDAIAQKKKDEVKTAKKLVEKAKATKVAKTKTVAVPDKKAAPASKTKAAAIPKTKAVAAPKPKPAAAPKPKATLALKTKAAAAPKTKAAAIPKTKAVASPKTKAANAQKTKTVATRKTKDVEEIEETSKPKQKSKVSKIKQDDSEAGPSNKPKVKAAVKPRPGKSPVTKSKPKPTAGKHKPEKDEPKEKISRQNGVKFQTEEDLPHLLAKKAASKPTKNMKEGRPRKLYNVDTSIDFSRKDLSDTELNVKPDHRKSLKSYASDTELEVTYNRKKAKVRKVLKKLDVEKETSKTDPSLTIVKKRKGKNSTADDVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCV4</accession>
    <name>A0AAV6UCV4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_004140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000476">
        <property type="protein sequence ID" value="KAG8182205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCV4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043764714" description="Sushi domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8182205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="420" mass="47414" checksum="F4A5891892CB610C" modified="2024-11-27" version="1">MSTLCVTLAFVLSVGLVSCEKPVVSCPAPRSPLHGQSFLYQDGQVVKYVCEPGFEIRGRPTARCVDGAWEDPAPMCIPMGETDDLEDLLLPPDTPEESADLVTPPRRPLFNWGGDEDIDDDEIDDGNSTATDDDDTPMGDQPRVRTVVYPNRVLLRNALLRRAALRSRVIELEEADRKNKEAGGRSVHLQGPPPSVLYLRRSGKSSDGPAGQQVRTAAVEQEGESTEQPQGDKGGDAQRQYYWWAAQHYYQHPQSAALVDYTSVHPYGLTESQMAWINSLHPETRDQYLRDIYGVRTDHVVEAQRAQAFLSRYGDAYNYYHPYYYYREPLAVLTQQDIVSTYDYSCNQAGSPFVRAPKLRNAHIAKYDRRQNPNAPNNHYLAVVYRCNPGYVMYDTRHTDLFCSKRAWIGTDPVCVRARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCZ6</accession>
    <name>A0AAV6UCZ6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_028272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000498">
        <property type="protein sequence ID" value="KAG8181733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCZ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08388">
        <property type="entry name" value="C2A_Synaptotagmin-4-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08404">
        <property type="entry name" value="C2B_Synaptotagmin-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000039">
        <property type="entry name" value="Synaptotagmin 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000181">
        <property type="entry name" value="Synaptotagmin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF369">
        <property type="entry name" value="FI18813P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="159"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="297"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8181733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="435" mass="48988" checksum="88B8629737FBC534" modified="2024-11-27" version="1">MKNQPHVGPGWPLTTPALIGICLGSTFFLVSLAAVTCFCYKRRSGSSSSLKPTSLKGRPDRPLVLRRPTAVKSPSSGSVGAVLPRKSPSPTSANKTPSPIGMHRSPTGGVVEKCGSNPSSRQHSPNVEQKNLIENENEKTKKDCDIKNEKEILVEKQCKLGQLYFRLKYNPDKLSLQVSIVRCSDLPPKDSNNGSSDPYVKLQLLPEKQHKVKTRVLRKTVDPVYDEDFTFYGINPNQLQATTLHFVVLSFDRYSRDDVIGEVICPLSGVDFEEVTGKQMEMVKEITPRNLKIRYQGRGELLVSLCYQPAANRLTVVVLKSRNLPKMDFAGLCDPYVKIYLLYNNQRIAKKKTHVKKRTTNPVFNESFVFEVPYNEGLENISLEFLVLDWDRVTKNEVIGRLELGPRSGGPAQQHWNEVCNAPRRQIAEWHKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UD08</accession>
    <name>A0AAV6UD08_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Diacylglycerol O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_017724</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a long chain fatty alcohol + a fatty acyl-CoA = a long-chain alcohol wax ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:38443"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
            <dbReference type="ChEBI" id="CHEBI:235323"/>
            <dbReference type="EC" id="2.3.1.75"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000505">
        <property type="protein sequence ID" value="KAG8181603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UD08"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047196">
        <property type="term" value="F:long-chain-alcohol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF1">
        <property type="entry name" value="WAX ESTER SYNTHASE_DIACYLGLYCEROL ACYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WS_DGAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1-like N-terminal" evidence="9">
        <location>
            <begin position="167"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="10">
        <location>
            <begin position="386"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8181603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="84199" checksum="C1EFC33EC0BEC142" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UD27</accession>
    <name>A0AAV6UD27_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000471">
        <property type="protein sequence ID" value="KAG8182280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UD27"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000012">
        <property type="entry name" value="F-box only protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039752">
        <property type="entry name" value="F-box_only"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125:SF5">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01198">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51114">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBA" evidence="1">
        <location>
            <begin position="109"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="295" mass="33658" checksum="C5AA2CF95D3DD888" modified="2024-11-27" version="1">MGNVRSSIKELTPDKIFKPQARCASVSEDNSNLANSSSKNDLSELDDVLVHILSFMSVEDLIFNCRFVCKEWKEIIDGNGLWKIKCKRENRCIPSAILNPIPQHYYRKIYIFNPFGRNLVYNPCGKDQFDGWMLRSIDDGDGFKVEDPPQGSDPVPKEVGSQSCFVTSYEWCIKCQLVDLIRRGVPKEILKLETTKVEVGEWYAARSDCAAEYKLDVSLLFLQRAIDPPKPPHDVFDHTDTIKQGKGKQWHKVSHTFQNLGESRCVCFQHSAKDLEKKKGHYGMKMTGSYVKVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEG9</accession>
    <name>A0AAV6UEG9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000488">
        <property type="protein sequence ID" value="KAG8181925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEG9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="10223" checksum="472E7410F40ABB76" modified="2024-11-27" version="1">MEPPTADGDRKSRPLKTFCREQTTRLTSQENYTHTKRKRLGIVFFSSSHTNRWALGTNAVNHWKWFGISSNPMFFVDNEPLRGIFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEZ9</accession>
    <name>A0AAV6UEZ9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_019686</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000454">
        <property type="protein sequence ID" value="KAG8182661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEZ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8182661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="243" mass="27700" checksum="8BD5EC3B4BD22618" modified="2024-11-27" version="1">MSYACKVCCGAFSSEEELGSHLTTHSEELSYVCKFCCDGVFSSEKELNSHLTECAEKKTYYCKVCPKTFHSKLQLEQHSSTHAEDRPYVCNACHMSFGYERSLKSHPCISNPKHTCTFCSMSFKFQADLDEHLNLHTGDRPHLCKTDCHAQEALVRYTGPYLKEIRIHLCQKSSESSGIREFIRKHYVSIKKQNPAFPILIRECEGVEPKIYARYDFGKESSASLSNHKSEQVLEVLKGFASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF26</accession>
    <name>A0AAV6UF26_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000472">
        <property type="protein sequence ID" value="KAG8182261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF26"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006178">
        <property type="term" value="P:guanine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050408">
        <property type="entry name" value="HGPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340:SF1">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="184" mass="20822" checksum="034AB52E729E2659" modified="2024-11-27" version="1">MQSSKYIVISDDDEGYPLETFCIPNHYNGDLDRVLVPCGIIHDRIERLARDIAQDYKDQPFTALCAAKSYEGSDSSGNLKVMGIDNLETLAGRNLLIVEDIIDTGLTMENLLKLLQQFKTKSIKVVSLFVKRTPKSSGYRPDYTGFEVPNKFIVGYALDYNEIFRDLNHVCIINETGKQKYAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHH8</accession>
    <name>A0AAV6UHH8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LIM interaction domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_006448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the LDB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000425">
        <property type="protein sequence ID" value="KAG8183248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHH8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030274">
        <property type="term" value="F:LIM domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041363">
        <property type="entry name" value="LID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17916">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51957">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LIM interaction" evidence="4">
        <location>
            <begin position="320"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8183248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="421" mass="47443" checksum="769E8FC509E403E0" modified="2024-11-27" version="1">MGRHTPYFGQPDIRIYEMNKRLQQRNEDSDNLWWDAFATEFFEDDATLTLTFCLEDGPKRYTIGRTLIPRYFRSIFEGEVTDLYFSLKHAKELFHNTTITLDCDQCTMVAHHGKPMYNKILGGQYPNELMKEQLAKDNAVVVCTEGRLILDFTFDDLMRIKSWHFATRQHRELVPRSLIALQVTQAQQQDPAMLEQLSKNITRQGLTNSTLNYLRLCVILEPMQELMSRHKAYALSPRDCLKTTLFQKWQRMVAPPGGNHRPGPNDFKMQPEVETQRPPSKRRKRKSSATNNANNTGTGTGKKKNNMSPGPPNFSLASQDVMVVGEPSLMGGEFGDEDERLITRLENNQFDATAAAANGLDDGDEFSGNPNVGPNQGGGPPPNWSGGPPQQQQDRNQSSGPGSVPQSQNQEDKKPSPAINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHU9</accession>
    <name>A0AAV6UHU9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_024609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000443">
        <property type="protein sequence ID" value="KAG8182866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHU9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043787082" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="104"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="318"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8182866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="407" mass="46090" checksum="DA0F6ED430AF37D7" modified="2024-11-27" version="1">MKFVISIFTFSLIVFVQCKETNRAIDEKDLFADEESERITVCIDEKLGCFPETEPGEDISFADSVSDWFENKYWRSSRERVGTEFHHWAPGKRQAKVITNWNFHEHIKEGGKFRPDLKTFFIIHGFHDKENPWMTDMKNALMRQGPCNVFLVNWNGGVMYGTAKANTWVVGAELGRIVQRLGLITGMKADRVHIIGHSLGAHAAGFAGKWVQNRMGGTKVKRITGLDPAGPDFDTVVANERLDRNDAEFVDIIHSNFASSLLDGFGLEKAIGHFDFYPNGGEQQPGCPTVLEGVAELSKETLEYINPTYKLYTLIAGDNKNIGDAYEDVKCNHVRSILFFIDSIRHPDCHFIAEECGSWDDYKAGKCSKALKVSMGYRARKYRYKIDPNASKKFYLSTNAKAPFCKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI70</accession>
    <name>A0AAV6UI70_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GMP reductase</fullName>
            <shortName evidence="8">GMPR</shortName>
            <ecNumber evidence="8">1.7.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanosine 5'-monophosphate oxidoreductase</fullName>
            <shortName evidence="8">Guanosine monophosphate reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_009936</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8 11">Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8 11">
            <text>IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:17185"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.7" evidence="8"/>
    <dbReference type="EMBL" id="JAFNEN010000400">
        <property type="protein sequence ID" value="KAG8183880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UI70"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902560">
        <property type="term" value="C:GMP reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000012">
        <property type="entry name" value="GMP reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00596">
        <property type="entry name" value="GMP_reduct_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050139">
        <property type="entry name" value="GMP_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005993">
        <property type="entry name" value="GMPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01305">
        <property type="entry name" value="GMP_reduct_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003470">
        <property type="entry name" value="PRK05096.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170:SF5">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000235">
        <property type="entry name" value="GMP_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="1 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP dehydrogenase/GMP reductase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="8 9">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="268"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="285"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="314"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8183880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="351" mass="37960" checksum="1F7F1B46D31D114F" modified="2024-11-27" version="1">MPHIENDIKLDFKDVLLRPKRSTLKSRNDVDLFRPFKFRNSGKLYNGIPIISSNMDTTGTFEIAKVLAKHGMFTCIHKHYTLDEWEKFAAENPEALKHVAVSIGTAQGDFESLCAIIKAVPAIEYICLDVANGYSEHFVALVRKVRAEYPSHTIMAGNVVTGEMVEELILSGADVIKVGIGPGSVCTTRKKTGVGYPQLSAVLECADAAHGLGGHIISDGGCTNPGDVAKAFGAGADFVMIGGMFAGHDQSGGDVIEKNGKKVKLFYGMSSATAMQRYHGGVAEYRASEGKTVEVPYRGDIEKTVLDVLGGLRSACTYTGASKLKELSRRTTFIRVTQQTNEIFCASEPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UK54</accession>
    <name>A0AAV6UK54_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maturase K</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000411">
        <property type="protein sequence ID" value="KAG8183676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UK54"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="30156" checksum="10E514D2401B9A9C" modified="2024-11-27" version="1">MVDSSSKHTASGLSYLDRCYSEYREVLSRSVCMQENEVLLYYSLIGVSPREYEFLRLLYSFLRRGQCKNEACKLFRRYPEYFWFQDKMFKNTCKLRPALVKLTDFYRQGGLVGLKCFRNTFSKFVHVNEEGKFQSWLYITVFLKMHLKQVGFFNLGEFMDSTGFKKDGLKRGRLLSKATKASYFQWGCNYIFGEKPVIFYLEMESHLKCERDSKIKARLGSRQQWRTKIPSMVPLLTTYHSMDPDFDEVLPLHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKJ9</accession>
    <name>A0AAV6UKJ9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000402">
        <property type="protein sequence ID" value="KAG8183826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKJ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8724" checksum="B0C3A6F816F6BDCB" modified="2024-11-27" version="1">MPTTIPDWRKREKRSKFPDLRMPSSDKADEKRTRGYRRVVVEKKKELRQKQQSSYRREVYVTKASDVAAIIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UL12</accession>
    <name>A0AAV6UL12_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_006781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000375">
        <property type="protein sequence ID" value="KAG8184378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="953"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1695"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8184378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1853" mass="204705" checksum="A223D64876E7BB79" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULN4</accession>
    <name>A0AAV6ULN4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_005121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000344">
        <property type="protein sequence ID" value="KAG8185142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULN4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043349986" description="EGF-like domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2 3">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8185142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="116" mass="12718" checksum="BADF28759781A4C3" modified="2024-11-27" version="1">MNVFMLGILVCLSSFWCKALAIYIASNDTVLNDANSSNVQSTFIIKHGVGSQEKTSQYIVVCNGKECQNGATECNTDIKCYCLEGWAGDTCAEVKTNNLTEHIAQLYVMEMNATKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULS7</accession>
    <name>A0AAV6ULS7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vesicle transport through interaction with t-SNAREs homolog 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Vesicle transport v-SNARE protein Vti1-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Vti1-rp2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_005223</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with distinct SNARE complexes that contain either STX5 or STX6. Interacts with NAPA and, to a lesser extent, with NAPG. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000368">
        <property type="protein sequence ID" value="KAG8184613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULS7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15891">
        <property type="entry name" value="SNARE_Vti1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000078">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREs 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000001">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREs homolog 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="16">
        <location>
            <begin position="121"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8184613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="222" mass="25329" checksum="D7790B2B6E635AC3" modified="2024-11-27" version="1">MASLMESFEQQYAAISAEITAKTSRLSNLSGVEKKLFISQVDRQMEEAHELLEQMDLEVKGMPPASRQKYQIRLQSYVAELSLLDKELVRWTQVKARISPRDELRDELFDGEYLRDDQKQSLLDNTERLERASRQLEGGYKMAVEAEQIGSAILTDLSSQRETIKKSKSRVQETNYDLGRSSRIVNGMIRGIVQQKLVLYGVGAVILVAIVLAIYFTVRKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ21</accession>
    <name>A0AAV6UQ21_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000304">
        <property type="protein sequence ID" value="KAG8186387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ21"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="115" mass="13245" checksum="B299FDDA97F8AF43" modified="2024-11-27" version="1">MLGLSRKEASRTRTDRSKGDSTSFNVHSEEARVNPDENELGRFKERAQKHKAACLNRHMKTQQGCSQGYIPRQSRIIQFQSSKKLRKRNVLWYGSQAVSVGDVRQLKMKVIIRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQY3</accession>
    <name>A0AAV6UQY3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000311">
        <property type="protein sequence ID" value="KAG8186144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQY3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10026" checksum="504C14DD1E093E00" modified="2024-11-27" version="1">MDLRRLLSARAESERYLLDKEEAQPVSFSQGGKVTGENGICCPLAPRNVSFLNTNATTGGGPQGCRVVKVGKFVWMCHITSIASRSIRGTLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URQ8</accession>
    <name>A0AAV6URQ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000298">
        <property type="protein sequence ID" value="KAG8186527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URQ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="44988" checksum="BEAD8D93E13C0834" modified="2024-11-27" version="1">MDEKLKLEMKDSPYPFEEFYQNMDSSEMLDNTNLSSAMSESTEPSVIKSNKRKAEDDGPVLYKKAGCVLKGMKSAELHAILYNDPIAFCQEVGILPESVKCFCCNENMRLETQHGALKRQMMWICRKKGNKKSRSIRMGTWFETSKAPVADVLWMMYMWLYKFPTNLMIHETDHSPKVIIGWNKKCVEVCRLILEMKNEPLGGEGKIVEIFDYKFKGKNLRNWGFCALELKSTKTLYVMVEDAKSGSLKKLLSKYILPGTTIFGLFWSRYKNLSKKDFNYLTQEKKITFYQPTLKTQMDTYEDFVAGVNRYQPLSHFVKNVNDSQFFEKMYRKSLANAPDAYIAFLEDIAMVYKPSEVYRAEERVKKEKDVIVKSEKEIKKEKIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URV1</accession>
    <name>A0AAV6URV1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000281">
        <property type="protein sequence ID" value="KAG8187047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URV1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7489" checksum="08DF4AEE3020386D" modified="2024-11-27" version="1">MRMDVMMSGNRRFHEPVLHASLGTRLGLVADPDCNKKVKEAWRSATGLYVILMGNGPLPCEEASDTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USJ8</accession>
    <name>A0AAV6USJ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Methyltransferase HEMK2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">HemK methyltransferase family member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysine N-methyltransferase 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methylarsonite methyltransferase N6AMT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Methyltransferase N6AMT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Protein N(5)-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_020055</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Methyltransferase that can methylate proteins and, to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. It however only plays a limited role in arsenic metabolism compared with AS3MT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16223"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer; heterodimerization with TRMT112 is required for S-adenosyl-L-methionine-binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000277">
        <property type="protein sequence ID" value="KAG8187184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USJ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000077">
        <property type="entry name" value="HemK methyltransferase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="17">
        <location>
            <begin position="69"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8187184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="225" mass="24838" checksum="4A739F4BE9C8BC18" modified="2024-11-27" version="1">MELADYSVLKKVIFEDVYEPAEDTFILVDALEKNLSLIQQLKYGFLGLEDTFILVDALEKNLSLIQQLKPAICLEIGSGSGVVISTLGKVLQNPYYLCTDINPIAASATQTTSKSNGLQVDIIITNLVDGLERLQNSVDLLIFNPPYAVTPSEEVGASNTFKATSGGFKGREVMDRIFPLVPKLLSKQGLFYLTCIQQNDIDEIALIMKSFSLDMTKRHIKELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UT49</accession>
    <name>A0AAV6UT49_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_005749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000282">
        <property type="protein sequence ID" value="KAG8186977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UT49"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17978">
        <property type="entry name" value="DEXHc_DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13245">
        <property type="entry name" value="AAA_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="27"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="252"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8186977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="691" mass="77863" checksum="4996C277099904EF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UT83</accession>
    <name>A0AAV6UT83_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_005756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000282">
        <property type="protein sequence ID" value="KAG8186984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UT83"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8186984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="182" mass="20412" checksum="E8FCAFABF3F7214D" modified="2024-11-27" version="1">MSGSVEKLGEVLLKTEIVDEEPAGVRKDAQKGLSESRIAELKTAFSILDKNQDGRINFSEMKTMLSNLGIRTDDCVVEALIQQASEKDDGLVSEEEFLSWMAEQDEIGGRENDEDDLMEDLLAAFRVFDKDGNGYITKDELKMAMDIIGEPVTEVQLEEMLKATDIDHDGKINYEEFVKILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTF8</accession>
    <name>A0AAV6UTF8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000297">
        <property type="protein sequence ID" value="KAG8186541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTF8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="156" mass="17386" checksum="9768DFDC4C7ABF9F" modified="2024-11-27" version="1">MATASTSNGIVRQGSAWFQRKVNLRPVHRGCHLVTDELLKQIPEVSKFSVGLFHIQIMHTSASLALNENWDPHVRADMEMFLTQLVPESTNFKHSCEGPDDMPAHIKACFLGSSLTIPITDGQLNLGTWQGIWLCEHRNRAGSRKVIITINGALNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUC5</accession>
    <name>A0AAV6UUC5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_024102</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000287">
        <property type="protein sequence ID" value="KAG8186856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUC5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF124">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL PYREXIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="11" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8186856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="197" mass="21489" checksum="0269A5520958859E" modified="2024-11-27" version="1">MKKCIREGADVQARNIHLWTSLHFAAQGGNIQIGTFLVEQNLDVEAVNKNGQTPLHIASAFGHKDMVQLLLKRNIDVKAVDYSVKTPLHFAAQNGHTNVIKLLLKNKASPASTDVLGCMPIHYAIVFNHREATEILLAEQSINASVVLRGFTALHVSAENGQLELVNLFLKKKANVNAKTDRLAAALHTASLHGHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWV9</accession>
    <name>A0AAV6UWV9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_018282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000228">
        <property type="protein sequence ID" value="KAG8188877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWV9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000002">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007020">
        <property type="entry name" value="PRK09485.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="7">
        <location>
            <begin position="38"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8188877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="354" mass="38797" checksum="9C4CF1217B53007E" modified="2024-11-27" version="1">MKAVCSQNQNTGIGDTFIRNEHYFFVEVLKKLLDVLLSSLMDASLHSQITILDGGLATELERNGLSLQGDPLWSARVLHENPDAIVEVHKSYLQNGAQVLTTSSYQASFTGFKKHLGLSHEESRKLLKLSIDLAKRARKEYNEETNAGDKNILVAGSIGSYGAALADGSEYNGSYAEDLSHGDFINWHRPRIECLVEAGADLLAFETIPALNEAEALMKILNDMPHVKAWLSFSCQSMHKTSHGDEISAAALNCMKIARSDQLVAVGVNCCQPEFAESLLKDISSVSHGYPLVVYPNSGELWDTTVGWTGTKGQPNHTYLESWIKSGANYIGGCCRTTPEDILEISKYVGQANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXH4</accession>
    <name>A0AAV6UXH4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRCA1-associated ATM activator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXH4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="860" mass="98234" checksum="362D2FD7D07CD172" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UY58</accession>
    <name>A0AAV6UY58_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_026753</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000234">
        <property type="protein sequence ID" value="KAG8188648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UY58"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07844">
        <property type="entry name" value="STKc_PCTAIRE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000131">
        <property type="entry name" value="cyclin-dependent kinase 14 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000007">
        <property type="entry name" value="Cyclin-dependent kinase 14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF246">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 63E, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="194"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8188648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="516" mass="58683" checksum="032C7264BA579459" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYK5</accession>
    <name>A0AAV6UYK5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Potassium channel subfamily K member 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_018113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000214">
        <property type="protein sequence ID" value="KAG8189460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYK5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF10">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8189460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14842" checksum="6134A289F5CAF731" modified="2024-11-27" version="1">MTKRGGKRGCCVRVLRLHEDNTRFLLLGLVMLAYMAAGAALFQWLEHATETEDADRYWRLHSDFLARYNGTVDPKDLDELLWEYGNASAAGIIHKRPRWDYSGSFYFVGTVVSTIGGEGVEPRREGHDHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0H4</accession>
    <name>A0AAV6V0H4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">[histone H3]-trimethyl-L-lysine(27) demethylase</fullName>
            <ecNumber evidence="12">1.14.11.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_018130</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(27)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60224"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15544"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.68"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UTX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.68" evidence="12"/>
    <dbReference type="EMBL" id="JAFNEN010000214">
        <property type="protein sequence ID" value="KAG8189478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0H4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071558">
        <property type="term" value="F:histone H3K27me2/H3K27me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1370:FF:000001">
        <property type="entry name" value="lysine-specific demethylase 6A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.20:FF:000001">
        <property type="entry name" value="lysine-specific demethylase 6A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046941">
        <property type="entry name" value="KDM6_GATAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048562">
        <property type="entry name" value="KDM6A_B-like_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048560">
        <property type="entry name" value="KDM6A_B-like_GATAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21322">
        <property type="entry name" value="KDM6_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21326">
        <property type="entry name" value="KDM6_GATAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="JmjC" evidence="16">
        <location>
            <begin position="856"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="476"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="804"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8189478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1160" mass="130876" checksum="5179DC9A564E4957" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V127</accession>
    <name>A0AAV6V127_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000184">
        <property type="protein sequence ID" value="KAG8190435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V127"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8958" checksum="62E034086E89E43E" modified="2024-11-27" version="1">MAISEQRAVLCSARNREVSCCVFRQQPGQDRRKKFNDLNGGVDFGIWRKELFIKITSSWLNDTVTKIAVFNRILGLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V130</accession>
    <name>A0AAV6V130_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_022519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000207">
        <property type="protein sequence ID" value="KAG8189707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V130"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043664042" evidence="3">
        <location>
            <begin position="19"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8189707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="672" mass="76826" checksum="103B4E3DDF58A0C8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1V4</accession>
    <name>A0AAV6V1V4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000183">
        <property type="protein sequence ID" value="KAG8190474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1V4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="200" mass="23031" checksum="7C741C3320C9914D" modified="2024-11-27" version="1">MPMFTLLSIFFTLSQEKKRKYFLKNTVSSPRTLENQTLNSCVKKGRLIYEDPQEIVKTGDLTVPRWTIQKEDLGPVWTPTLSMDPLGLDLDLDFLLCLFVLEKCFRLSVGVTCFGCVTTADDLYRHFSPDAFGVEPETNLISDDHAKKKNANRRKKEQKMDSHRFCPSAIENRFPVRPLNRPWQLDSFSDSAVVWGPIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2V2</accession>
    <name>A0AAV6V2V2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000191">
        <property type="protein sequence ID" value="KAG8190188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2V2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="109" mass="12266" checksum="1C800FA89711CF3D" modified="2024-11-27" version="1">MSTNLYIKNPWLTSGAASSVVGGRKEEVNTPRENEANQKVVHKWHNPKSNKTDKTELKPKPKLTLLYMGRGETTLSEPLSPPTKNKLTCVTSLEVDERRSEVRGNRSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3M1</accession>
    <name>A0AAV6V3M1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Solute carrier family 25 member 46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_009267</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000184">
        <property type="protein sequence ID" value="KAG8190430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3M1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090149">
        <property type="term" value="P:mitochondrial membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039158">
        <property type="entry name" value="SLC25A46"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252:SF2">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN SLC25A46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252">
        <property type="entry name" value="TB1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="271"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8190430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43133" checksum="B1315FB4CCCC0404" modified="2024-11-27" version="1">MSSKVPIDLQPIHEESPPYTRGAYYNDSFSYPPIDPERPGPSTAYSPENPDADHVQKFASIGLEISSAVIGSVISHPCIVLRRQCQVNRKATRYHLSPFTLLPVLLRLQNRQGLLCLWKGCSGIFILRGCTIVLETFLAEATPFPREVTSNSSLKQLSQHLLLKLISFGVLTPFLCASLAETVQSDIASEKPGVLDCLKEGVCRLFKLGTPRSSRLLPMWQLFGPSALVGVSTYVLSSLIQSVLHWFRSLKLRNAQEKAVYECQASQSSAATYLDNLSIFHFSSFMASVIMYPAETMVHRLYLQGTRTIIDDLDSGTSVLPVISTYEGIVDCFNTILSEEGASGLYKGFGALILEYAIQALIVKVAQVTFRELESLFGTPNVKRISADHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6V2</accession>
    <name>A0AAV6V6V2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6V2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="66" mass="7498" checksum="8E58B5BF4FB927CA" modified="2024-11-27" version="1">MATRGRSATSRRRNSSVTCQKRPKYLEKELITGTSCLAGKQTYMHRVSGWLSNGRVPDEQNRALEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6W2</accession>
    <name>A0AAV6V6W2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000141">
        <property type="protein sequence ID" value="KAG8192319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6W2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="486" mass="54844" checksum="844D109AAF3D24CE" modified="2024-11-27" version="1">MSNNLKNNAYGRIQNRHYSSGYEGDESCDELLIDTEDPTEGAKAVGPTKSASETMMEVNFPEDKFSERHLRNSEGLLPRSSHVSRGIADYSDLDFVNEISAKFSRLNTSPKMFGGHDLNPSTCHSDNFESLEQKSQHFTGKKSNIKRKQHEQFRKSPRFETRGLFPETPDDFCTKFKTLQGSNEKLITLDNVRDIKLKSKDLSGLNNHGFASEKKQQKQVSKNKDISFKNVAKPDTRISRNCETAGETSKKYKSPNSASNSSYGFTKNKMAENDKVKVRTEKYNRRIKEKTVSNISEDTNAKASNEVMRVNNSRIEITPKRPNLKNRRISLPAMQGSLSDIDTIPFDRRNSLSFGLPNPKKLPISKVTQSSKFSKKRLASSPIKNLTPIVGPQQTTSTKRRTDSQPDEPSSKFRKRCLSSTDAEEGDITDIRHRVRSSSDGETHESVSNESSTRKRVVDDIATTASGETQYTSKKLRQNHNINPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7S3</accession>
    <name>A0AAV6V7S3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7S3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="108" mass="12062" checksum="70BDE4AC3F1BF10A" modified="2024-11-27" version="1">MPQRQRTRPTDTTFITPTSLRSSPFVGKVNQRSPKVIPALSSRESLAMRFDDRAVSMTPTPLVSHKAARDKQQGPPLEFKDLVSMTPCVLGTYTLVKAARNLFRDFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAX6</accession>
    <name>A0AAV6VAX6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000115">
        <property type="protein sequence ID" value="KAG8193784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAX6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="98" mass="11327" checksum="1FA8F791947BB9BC" modified="2024-11-27" version="1">MALLKECRSAGNNLPNPLSWPQSDIILVLNHRPLRTDMLDGGVYTFDKWPHLRWILGKRFLKFRRLIAQEDSGIQVLSRMFVLIGIDLLVCHATFDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCP4</accession>
    <name>A0AAV6VCP4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_005043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000115">
        <property type="protein sequence ID" value="KAG8193745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18490">
        <property type="entry name" value="BACK_BTBD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18286">
        <property type="entry name" value="BTB2_POZ_BTBD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043225">
        <property type="entry name" value="BACK_BTBD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427:SF7">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26017">
        <property type="entry name" value="BACK_BTBD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="969"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1347"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1466"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1650"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="859"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1690"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1710"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1767"/>
            <end position="1784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1802" mass="201812" checksum="D799500FBE23AAF1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VD04</accession>
    <name>A0AAV6VD04_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_013267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VD04"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="114"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8194515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="193" mass="21740" checksum="4C083AD53BF1B72D" modified="2024-11-27" version="1">MSFLGKGKKQDLLVVCEELGEKVDHLSKVPEIKKKQKKPHTRRREEQSGICLTDEMMTYCHERAASHLGIAKTKDALFKTFYWPNCYREVEAFVKSCDLCQRVGKPQDKKKAPLKLVPVITEIFSKINVDAVGPLPVTPSGNKYLITAVCMSSKYPDAIPVENLKSTSIIDALLQVFSRMGFPKELQTDQGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDL6</accession>
    <name>A0AAV6VDL6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SSUH2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000098">
        <property type="protein sequence ID" value="KAG8194794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDL6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052789">
        <property type="entry name" value="SSUH2_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46337" checksum="5AE42B6635FB57E0" modified="2024-11-27" version="1">MSWYRRASAPGLGKTSNRRRSSASYSVAVGRRTSNGSSRIRSSSKGHIRDFGDDDIEVFLPPLEEMPTVVGYEDVTFEMCTVNPPPAVLVTEDDDASDEMGDLKPFTELPHLSEKEIRKTLIRHADSRCAFDKDAAREMRIVRIDYRPGYKYTLESFTETRQVAWSFEPYTGGPLDEVGPAPPGPWEVGGGVGRPKPFHVHCTCLEVPHTDLLTTCKACYGVGSRRCTACSALGWERCSLCLGDGHKISMQGHRERCFRCIGTGRKKCWKCGGETIAVCAGCSGTGQIRCFIALNINWSNHVDTDILDPSDALPISEKLEYVKGHLVFQDERPMLASASFPVKDLECIANSLLEKHQRISSGEKLLLQRHGVWAIPVTCVTYEWKHKQKSFFVYGSKNEVCAPDFPERYCCCCAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEN8</accession>
    <name>A0AAV6VEN8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_003044</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide. Man(5)GlcNAc(2)-PP-dolichol is a substrate for ALG3, the following enzyme in the biosynthetic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="4 14"/>
    <dbReference type="EMBL" id="JAFNEN010000109">
        <property type="protein sequence ID" value="KAG8194103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEN8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="16">
        <location>
            <begin position="39"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="15">
        <location>
            <begin position="269"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8194103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="470" mass="54361" checksum="03217F5A125ECA5F" modified="2024-11-27" version="1">MFLFVIRVMFFVFPVILFVKLLFFIKRFAWKRRAKDTVSVGFFHPYCNAGGGGERVLWEAIRAVQKEYKNIHCVVYSGDNVSAEDIIKNVELRFNIKLHRGIQFEYLRCRFLVEAKYYPFCTLLLQSLGSVVLAFEALSKHVPDIYIDTMGYAFTFPIFRFFGSSRICAYVHFPTISTDMLKVVKNRQVGVNNRRFISNNKIFSECKLVYYKIFAFLYGFVGRRAEVIMVNSSWTRGHILELWKKPQRTFTVYPPCDVSQFNNIPLESHNGKSRFLSIAQFRPEKDHQLQIRAFHQFISELELGTNPVKNNGPLPTLVLVGSCRDEGDSRRVDGLKNLCENLGILKNVEFKVNLSFRDVMKEMENASVALHTMRDEHFGIGIVECMSAGLVMIAHDSGGPKMDIVVDFNEKKTGFLATDIQSFADAMTNVWNMKETDLYEIRKCARESVSRFSVNKFEETFLQSFRLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VG72</accession>
    <name>A0AAV6VG72_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_003136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the MEI4L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000101">
        <property type="protein sequence ID" value="KAG8194666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VG72"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000800">
        <property type="term" value="C:lateral element"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025888">
        <property type="entry name" value="MEI4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28575">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN MEI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28575:SF1">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN MEI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8194666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="390" mass="44754" checksum="1938C074D58CEBEC" modified="2024-11-27" version="1">MPPKRRISNLNILYYKMMQSEQSESQEIPYTPEVLEETETAEDRGYTTYVQRVKLAVAVAVIKSTPRGTQPKDFATSLVQSFTRDISLWETKYHQLEEMVFSLEQKLETVNMKAQVDFAYPGLDNYETFHSHNSDPPTTNAVNEMNVKDTLEFVRSFILVNSLSSSHTLKESDIKSEKHNKMIVKSLINLLGFLKSEEGLKMEFNVMKQAVTEIHKLFDAPFGKQNTELMDVCLNFLDELLLEIHKTLEINKIDDQHRRSSLIQMMAEHNALTIPYLCRLLREITVTSDFLAGVFREDNDNFLPLLHSENAYYVLQATEGVLSTLAKQNSVLSAIKIPESALREWENTTIKSLSRLGQHLPMYCVYVWHLKSLMTAVFSVTSDDLSVLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VI14</accession>
    <name>A0AAV6VI14_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_002989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000080">
        <property type="protein sequence ID" value="KAG8195728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VI14"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043809474" evidence="4">
        <location>
            <begin position="20"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8195728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="325" mass="37273" checksum="9C53826EC8605023" modified="2024-11-27" version="1">MLLKLFVFLIVSTTVLTLGQVQNDPETICPPADLLSPYCKCSKGCDLCPATVECSDVLNFGDLEAVFRNTPDWTFWHFSIVRSSFPYIPANAIVEKRVRNLYLRNNTMYTMFDEPPASTNLLQELELTDLRLLRGVSWDVYSTLEHLKEINLTNFKILKIDQEFVHHFPQGLTGLYFRETRTKRLGDDAFANLANLTRLFIRDTQISELKRSMFPPVSKLIAMHFSGNQISSLPDDLFTNMPDLRGVDFSNTNVVTLPESVFGRIMPQLGVLYLEGNAVNCNCEMKWIPKLKVLPYYARVECTRPKELEGFTLKKLKEAHFVHCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIB0</accession>
    <name>A0AAV6VIB0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_012326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000069">
        <property type="protein sequence ID" value="KAG8196512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIB0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="28"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8196512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="174" mass="19196" checksum="8F4E7EF38DBE4C8D" modified="2024-11-27" version="1">MPVVPVTIINGHVATSQRKVCCALHTDFLARQPGLCKLGELLFGGICVGLMITYGTPVWITLGVAYPLFLVTSSAALVSTSVLLFCYLVSEHTYRAIRTTVLEIFQNLTASVLYAVGSAFLLMHTTFFLWPMYIIIPYFQAYPALMTAGVFGCLSSFVHAVDAYCAYRTFRSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJL8</accession>
    <name>A0AAV6VJL8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_007840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJL8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8196104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="155" mass="17439" checksum="EDAAB3BB5E6D049D" modified="2024-11-27" version="1">MGEEYLVNIFQVAVVVAFFLCWAPFHAQRLMAIYIVNKTPTAVVIYTTLTHISGVTYYVSATINPILYSIMSNKFRQAFKDTLAHCGATRYERSSSLKYNSTLRSNFSSNNNSMRKKRSSESSKPNGNGHQDWRHLAVNGGVRKESTNGALTVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKZ4</accession>
    <name>A0AAV6VKZ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">U5 small nuclear ribonucleoprotein 200 kDa helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_023200</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000065">
        <property type="protein sequence ID" value="KAG8196688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000048">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="492"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="686"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="1337"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1545"/>
            <end position="1753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8196688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2140" mass="244506" checksum="207C6379C49E4C91" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VL43</accession>
    <name>A0AAV6VL43_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein FAN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_007268</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000054">
        <property type="protein sequence ID" value="KAG8197532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VL43"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057496">
        <property type="entry name" value="FAN-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25400">
        <property type="entry name" value="PH_FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="5">
        <location>
            <begin position="178"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="4">
        <location>
            <begin position="280"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="703"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="749"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="791"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="872"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8197532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="905" mass="103038" checksum="559247C1C11D9C75" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLA6</accession>
    <name>A0AAV6VLA6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 19">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="5 19">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_006577</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the NSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 19"/>
    <dbReference type="EMBL" id="JAFNEN010000066">
        <property type="protein sequence ID" value="KAG8196667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLA6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000270">
        <property type="entry name" value="Non-structural maintenance of chromosomes element 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.220:FF:000001">
        <property type="entry name" value="Non-structural maintenance of chromosomes element 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16 19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0779">Telomere</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12 19" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="171"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8196667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="232" mass="26731" checksum="81C4B8E02D16E435" modified="2024-11-27" version="1">MGELQLQHQMFLQAFMWKKVCDSEEVRMLHTKCHDSVNVPEGDLKIFIEKINCALQPLSMNIKKGIDELTAKQCYVLVNIADTPISRLSSEYESLDLELFKKIVSSIVESEEGKISSTTVLNFADDINKTLTKKVSRRDVNDILKKFIESGWLCEQRGYVFFSTRAIFELQHFFKENFPNSITTCVWCKNIVFQGASCISCGKKVHIYCREHYVERTGNRLCHACNSNFCDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLJ2</accession>
    <name>A0AAV6VLJ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitotic checkpoint protein and poly(A)+ RNA export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_003563</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000068">
        <property type="protein sequence ID" value="KAG8196546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLJ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000084">
        <property type="entry name" value="mRNA export factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8196546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="41946" checksum="49EA965A511BC0A8" modified="2024-11-27" version="1">MQLELSQPKMSLFGSSGFSSNTGVFSNTTAATQNPMKDFEVVSPPDDSISSLAFSPASLPQNFLIAGSWDNQIRCWEVQNTGQTIPKAQQTHQGPVLDVCWSDDGSKVFSASCDKTVKMWDLNTNQAIPVAQHDAPVKTVHWVKAPNYSCVMTGSWDKTLKFWDTRSPNPMMVINLPERCYCADVVYPMAVVGTAGRGIIVYQLEGQPQEFKKVESPLKYQHRCVSIFLDKKSQPCGFALGSVEGRVAIQYVNPQNPKDNFTFKCHRSNGTSNGYQDIYAVNDIAFHPVHGTLATIGSDGRFSFWDKDARTKLKTSEQMDQAISRCCFNARGEIFAYAVSYDWSKGHEFYNPQKKNYIYLHSCFEELKPRNKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLP3</accession>
    <name>A0AAV6VLP3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_007247</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000054">
        <property type="protein sequence ID" value="KAG8197509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLP3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15210">
        <property type="entry name" value="7tmA_GPR84-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000312">
        <property type="entry name" value="protein trapped in endoderm-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF71">
        <property type="entry name" value="PROTEIN TRAPPED IN ENDODERM-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="56"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8197509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="388" mass="43700" checksum="75F9749574D666DA" modified="2024-11-27" version="1">MDSAVRYLLQANQSISESPSILQEAGSADYLLKYPRATTLFATACCILFIVFGVLGNLVTILALSRCAKLRNATTAFVISLCTADLLFCTINLPPTASRYIHHNWVLGETLCKLFPFFFYGNVAASLLSMTAITINRYVLINHYKYYDRIYRPRYIALMIAFCWAFSFSLLAPTLAGVWGEFGYHAPSFSCTILKKAGRSPKKFLFVLGFLFPCLIIVVSYSCIFYRVHKSRKNVEAHTPSVAKGVSGPPVVRQLSHRQDEIRLTRMMLIIFCSFLLCFLPLMVVNVLEEKIRMPTIHVMASILAWMSSCINPVIYAAMNRQYRQAYVRLFCGAKRRFIGGHNNSTSSNARSGSGHSKTLMSEVFNFSPNKNGNVDDKNKKNEVENKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMD4</accession>
    <name>A0AAV6VMD4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000058">
        <property type="protein sequence ID" value="KAG8197240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMD4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000032">
        <property type="entry name" value="Fasciclin domain-containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF124">
        <property type="entry name" value="FI05614P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="105"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="236"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="420"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="554"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="698"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="844"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="976" mass="107420" checksum="2CFAB7120E6689B0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMH9</accession>
    <name>A0AAV6VMH9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spidroin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMH9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1350">
        <property type="entry name" value="Spidroin domain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021001">
        <property type="entry name" value="Spidroin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038542">
        <property type="entry name" value="Spidroin_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11260">
        <property type="entry name" value="Spidroin_MaSp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spidroin C-terminal" evidence="1">
        <location>
            <begin position="83"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="182" mass="17222" checksum="CE1C9CA899D178B6" modified="2024-11-27" version="1">MERSWCSAGRGASAGAAGAGGYSQGVGDYGQGAGTGAAAAGAGTSGAGFASAGGYGAASTGRYQSSAVSAAVASQIGQTLASTTSRLSSPEASYRMSNVASALSSGGVLNLDALPSIISNQFAQVSSSSAGASSGEVLVQVLLEIVSSLIHILNSSSVGQIDMAGIGNSAAAVSQSMAAVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VML9</accession>
    <name>A0AAV6VML9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_014939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000055">
        <property type="protein sequence ID" value="KAG8197458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VML9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF6">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8197458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="339" mass="38189" checksum="A83A7D0E02D5C003" modified="2024-11-27" version="1">MADGQPFQDENDISINGDADPKDSLCRDFLRNVCKRGKLCRFKHPETYEAESLGKKDIVFCHDFQNKECSRPNCKFVHCTKQEEEIFRSTGRLPETVLESMSNAAPMAYPKAPICKDYLKGECRRAGRCKFRHLTNLEYQMETNGLNNHHKRIDNSFNCYEPQLKRRAFENSFPEPHFPHSGEQRPMMPPAHYQMLEEENAMLMHKIQELKKQVVDLTATNEFLLDQNAQLRVSKQTLVSPISQQLIPHTLTPTISSMPPPNITQLSQIPLSTDLGGASLAPDITLTPVSLAPSQVTLPTISAASLSQSLPQTIITSTALISYPIMTQSMRPVIPHSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VN94</accession>
    <name>A0AAV6VN94_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000043">
        <property type="protein sequence ID" value="KAG8198134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VN94"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="152" mass="17524" checksum="B02B060A5F328412" modified="2024-11-27" version="1">MDETYYRELIELNEVIKGVQISERYLKRRSPKKTSPQTPAKSPDMTKFAEQSLVVFCCLTCFCLIAEAIDCRKFVFAPRCRGVSAKRSAKLNNEELRELGEMEESWGADWPARSSVSDDVIADSTTFDSRRKAILQKLLEKFNDYNLHDDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP02</accession>
    <name>A0AAV6VP02_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_007288</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000054">
        <property type="protein sequence ID" value="KAG8197552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP02"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000277">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000033">
        <property type="entry name" value="paraplegin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF8">
        <property type="entry name" value="PARAPLEGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="313"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8197552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="754" mass="84464" checksum="C6E89BD29FADF611" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP64</accession>
    <name>A0AAV6VP64_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_021534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP64"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032526">
        <property type="term" value="P:response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000073">
        <property type="entry name" value="esterase OVCA2 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Serine hydrolase" evidence="4">
        <location>
            <begin position="43"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8198280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="254" mass="29023" checksum="CD332B1E440FB43D" modified="2024-11-27" version="1">MLTSECVQKFQNQKVNILFKVQWLFLYLKWVFVLQLIMADSNKKLKILCLHGYRQNSFSFKQKMNGFRKCIKNIAELVFIEAPHAISGDSNSDCDQEIGQTFSWWFCDETNNFSSLTECEVAKGFKESIDLISQTFKTLGPFDGILGFSQGAAIVALICCLKECHEFAYDFKFVILISGFKSLAKCHQYLYKNPATTKSLFVYGLNDTCISKERSGLFSEVFLMPTIVVHDGGHYVPCHSDVKKQYVAFLKSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPL1</accession>
    <name>A0AAV6VPL1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_026468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPL1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8198570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="132" mass="14783" checksum="3F3E4976CDDF5185" modified="2024-11-27" version="1">MGWLNLYYGFWKGTMLIAAVLLLNCTVFSLLYSDFTYSPGKASSEFTADAIQSAVVTPKSTRKPVKTLQSEDKVQEATQTDSCDMADQETESRLPVEDSQPIQTANNSLPLEEQPWCNRLAYMVQDIPICVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VR09</accession>
    <name>A0AAV6VR09_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000031">
        <property type="protein sequence ID" value="KAG8199124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VR09"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="10678" checksum="D372FFB614675B00" modified="2024-11-27" version="1">MYLRYLPIVISVWGHYYFVGTQLSKHLLGQCSRSRLSDYESINNSPVSSENNNLMAKSLAVQTMDKVNRCSMCRAKTRHGVGVEPQSLRSPKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSS0</accession>
    <name>A0AAV6VSS0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_022148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000025">
        <property type="protein sequence ID" value="KAG8199699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSS0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043316561" evidence="2">
        <location>
            <begin position="21"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8199699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="396" mass="45700" checksum="FED40C59D9FE8129" modified="2024-11-27" version="1">MNSFLKILVGAICLCSCVRAQIKYDRHPVAQKVQYDDGGETYQPYTHDKKDSIKKSLPGDYGKSYGESAPVYEGPIDSPYPQKQIYSNPLEKPVSYYPSKTDYLPEEPRKYDYEEPTYHSAENSYDKKKPIEEYKRTKYENLKSKSTPSDEHEELQYSQDPEKPSYYQSNQHREAPLPPLSYQPSHYASEAPKSSYPVATQSYQPLQEPSPYQPNSPEAYQVLYQPAAQQPAHYQPAQQPAHYQPAQQPSHYQPAHQPSHYQPAHQPGHYQPAQQPGQYQPEGSYPQSAPSYQPGKPTSLVKRDPKLPLYFTMYEKRIIQDPTDQYGKGPWRYLTYGHGITYGSKEPGKVFEKGYGYIRALGRDHCKLPENQCPPKDDKPFEYDGRKEPYFGYRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUY4</accession>
    <name>A0AAV6VUY4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000023">
        <property type="protein sequence ID" value="KAG8199883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUY4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="8746" checksum="E0D0A8AF2BF7EBCF" modified="2024-11-27" version="1">MSLCVVQPFPLGESQLSVMTKRQVNVGRAAGLYGFCSHHKSVYGASLSKPSTARYHLEQRELDLGHEQGSCYSGYFSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVH8</accession>
    <name>A0AAV6VVH8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_000893</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05170">
        <property type="entry name" value="PIKKc_SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000010">
        <property type="entry name" value="serine/threonine-protein kinase SMG1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000008">
        <property type="entry name" value="serine/threonine-protein kinase SMG1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031559">
        <property type="entry name" value="SMG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039414">
        <property type="entry name" value="SMG1_PIKKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF71">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15785">
        <property type="entry name" value="SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="13">
        <location>
            <begin position="2083"/>
            <end position="2420"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="14">
        <location>
            <begin position="3502"/>
            <end position="3534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1827"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="2442"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1843"/>
            <end position="1855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8199801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="3534" mass="397284" checksum="F731168D85788DDD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVU7</accession>
    <name>A0AAV6VVU7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000013">
        <property type="protein sequence ID" value="KAG8200775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVU7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="11527" checksum="A793ADFDF13C6F04" modified="2024-11-27" version="1">MKKEKLTCTTLTLGNLKETIRKQGARASDCPSPRNTYKVPKGLSGGIPSCKLGLVPEVSFVQLFGAVFAACWDDFLTYPASILVWMESTNRGCVVWSLGDKRGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVV5</accession>
    <name>A0AAV6VVV5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000013">
        <property type="protein sequence ID" value="KAG8200790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVV5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="143" mass="16114" checksum="0E17FA9BBA939C20" modified="2024-11-27" version="1">MRHDGRAVWGHLLPVLQMIQKTWPHINTIHFQSDGPTTQYRNKTNLFLLTYFANKLGLKEVTWNFSEAGHGKSSADGVGGQLKTKADHFVAHGTDIPDAHTFYTVLKNSEIKVQLFQVSTKDIEAIDEHNMLGLKAITNTMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VW88</accession>
    <name>A0AAV6VW88_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_001921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000020">
        <property type="protein sequence ID" value="KAG8200064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VW88"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="673"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="749"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="858"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="867"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="894"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="968"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8200064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1118" mass="119472" checksum="C44B5E996F682BD7" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXM3</accession>
    <name>A0AAV6VXM3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_000558</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXM3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="11"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8200478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="476" mass="52955" checksum="1767F3F19CC302FF" modified="2024-11-27" version="1">MATVAILGGGISGLSCAYYLKTLGSSKLKYVFLLDKSPKFGGWIQTTRFPDGAVFEHGPRTLRVGTKAGYNALVLADKLALMPRILPLTKDHPTAKTNFILTQNELTPIPRGFKALFTRSPLFSEKLPIRYLFHELNCKREILEDESVYDFARRRIGDEVARKVLDPMCRGISAGDARELSIRSMFPGMYESEVKHGSVIKGSIRDGQEAISGYRDFAIVQKAQREFWRMWTLKTGLTELIDALACTVEERGVTDLIFDAKCSGLTFKDNKAMVAVDNENIQVDHIFSSIPSQELSPLVQSYPTLAEELKSIPSVDVAVVYLEYTGDVLQNNGFGFLAPSHEDSKVLGIVFDSCCFSEMNGNSKTRITCMIGGRWFKEVLGDPETVSEDAILKLAVSAAGKHLRISEQPVRHKVVLQRQCIPQYVLGHHKKLEKIDEEIKKHNLCMSLIGASYKGAGVPDCIYNAKLSVEKYLSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZJ2</accession>
    <name>A0AAV6VZJ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_011228</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000004">
        <property type="protein sequence ID" value="KAG8201553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098882">
        <property type="term" value="F:structural constituent of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019323">
        <property type="entry name" value="ELKS/CAST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861:SF0">
        <property type="entry name" value="BRUCHPILOT, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861">
        <property type="entry name" value="ELKS/RAB6-INTERACTING/CAST PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10174">
        <property type="entry name" value="Cast"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1223"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1520"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1809"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1911"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="331"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1223"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1520"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1935"/>
            <end position="1947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8201553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1989" mass="232304" checksum="AB50443BAD8B5762" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W064</accession>
    <name>A0AAV6W064_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_016757</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DNAJC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000006">
        <property type="protein sequence ID" value="KAG8201271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W064"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000036">
        <property type="entry name" value="dnaJ homolog subfamily C member 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044632">
        <property type="entry name" value="DNAJC25-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44176">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44176:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8201271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="318" mass="38047" checksum="4D72E5E21192AF63" modified="2024-11-27" version="1">MDGVYSLIDGLYCGQQECYSVLGVERTASKNEIAKAYRLLAKKHHPDKHRTLEEKKKASEIFTLIATAYEVLKDDESRKDYDYMLDNPDKVYGHYYRYYRRHMAPKVDVRIVIVVTISVISLVQYFAACSRYKSAIKYLVTVPKYRLKAMEIAKEENLFATSKKKDRRTKEEIKEEYENVLKKIIENKMDIRGGYSKPSLLDILWMQIICSPYTLISYVAWYIRWMWKFNIQKQEYGEEEKIYLIQKNLQCSSVQWEAFPDNEKDTCFKHKLWMKENYKVWKKEKEMDLKAQNADSGRYKMTRRYLKNQGQRPISFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W0B6</accession>
    <name>A0AAV6W0B6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sodium-coupled monocarboxylate transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_012830</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W0B6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8201771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="71896" checksum="CA785FB8AE583518" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDW5</accession>
    <name>A0AAV6TDW5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006325">
        <property type="protein sequence ID" value="KAG8156100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDW5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8156100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="274" mass="30534" checksum="E325D00CE12CCD7B" modified="2024-11-27" version="1">MQARTDISPDGDGGVSYEDGAARRGRRRRTTDVDEDDDGTRDALTNLRTLDTDYMRTTTRRDNARHYGARSASTRRNLLRSDARQVCATNRPLTIHGRCGRKTRSTARESATVPAARTRDATTRRRDATTGQTRERRGRNGTAICERATSGRRQDANLRRDVRRPTERGKELTVRVAAVRTTTIARRTYGDDVAGPSERYKYSGTAQVTRRTRYTASGERHGGACTAGLGLTRNAARRPTQGRLNAYVTYSDGANATTDCDERTRLTDATRRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TED9</accession>
    <name>A0AAV6TED9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_006742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005937">
        <property type="protein sequence ID" value="KAG8158047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TED9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8158047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="9753" checksum="D1CF12437885FD9E" modified="2024-11-27" version="1">MLKKLFLLDTCEHTSECDNGMECQNKDGVGHCQCAPGLSGDKCDIVDECVSGKLKNCTTDTGGLCKFVIDKPVCDCGVGKGFDTKLQTCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TF07</accession>
    <name>A0AAV6TF07_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005617">
        <property type="protein sequence ID" value="KAG8170327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TF07"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="63" mass="6986" checksum="E38060E561067BF3" modified="2024-11-27" version="1" fragment="single">FQDNLTPNQNSYSDSVAKNLLEPSLTVSVDTVFKGILTPNQKSYSDSVANNLLEPSLTLLWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFQ7</accession>
    <name>A0AAV6TFQ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005123">
        <property type="protein sequence ID" value="KAG8170625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFQ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8258" checksum="F294A731CB5A6D09" modified="2024-11-27" version="1">MAFPKKYRIVRGVPLSLHWVPPSVLSRGHPHHTQLNPSPMEFAEHSVYSGAPNLPGTGKDSFEMRPKRKNNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFR7</accession>
    <name>A0AAV6TFR7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005081">
        <property type="protein sequence ID" value="KAG8170654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFR7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="123" mass="12818" checksum="63CE8D764CD6BFDD" modified="2024-11-27" version="1">MGLEKAPGANESTKGPGEVAAFGIPPSLAGGAHRGPAAFSPLWNGGVLAHTLGPERWGTMPGQDEGPRENLVEVRSGSDVQIDRQTGSSGVRLIEPLVAGFSPRSFPQDSWRSLNSVSSVKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGD8</accession>
    <name>A0AAV6TGD8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of rDNA transcription protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004755">
        <property type="protein sequence ID" value="KAG8170859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGD8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20491" checksum="8E6F61B48DE66F93" modified="2024-11-27" version="1">MVASHHWPLDQAHEPSVRTCGSSRTEQDYYRNDESSVVKTNLSRDGLNPAHVPYKWVNNPTLGEFCFAMIGRADIEGSKSNVAMNAWLPRASYPCGNSSDTSCIKLVKSKGSIGHAFAVRIHTENQDQASFCPFALREVSVLAELALGHLRYHLTDVPPQPTTHLNLSSERIARYKEAARLGLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THR7</accession>
    <name>A0AAV6THR7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004439">
        <property type="protein sequence ID" value="KAG8171093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THR7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8395" checksum="B3EE1FBDB7410BDE" modified="2024-11-27" version="1">MNGNFLVSVSHHLALIMSLALVHTAGLYYRLNIFMRLSDWLSIGFRFLADVAEKMPELDYLEEIKVVNKVALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIS3</accession>
    <name>A0AAV6TIS3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003620">
        <property type="protein sequence ID" value="KAG8171724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIS3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8696" checksum="69384EA278DA5D7E" modified="2024-11-27" version="1">MANRPDCLSNQHLHGVLISASHRTPYGVWFIPQRPFCLPKVATGHSLLSRSGLHVHARRTFSPFKFENMLSRFAPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKI4</accession>
    <name>A0AAV6TKI4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrD-like helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_012019</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002832">
        <property type="protein sequence ID" value="KAG8172314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKI4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="5"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8172314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="460" mass="52773" checksum="E4604C19CA7DBBB8" modified="2024-11-27" version="1">MLLQGPPGTGKTHTIIGLLHKLVEDIHPKILVTAPSNAAVDEIGNRLVHLNSQLKIVRVGIPNQINQNMLQYSLEEKAKKMHEEYEIKYKYEEIETLQSEIDRDKHKEDHKTEERIKILAKQIKMIKQQISTLKADYYRKRRQYQETVLKESDIIMSTLGSCCHSIVKTVYGPNSRNPFTCCILDEASQCTEIEALQVLNFGISKLILIGDPQQLPATVSSKFAANYGFDRSLMERFHEYFSKDEKNNPIYMLTEQFRMHSEICRFPSKQFYRNLLVTSAKTDISYKAFPIEPYMVFNIINSQESDYDSSKTNEKEANATARICEQLLGLNAEPKPSIGIITPYAAQRTLYKNLLNKPTYKHIEINTVDGFQGREKDVIIVSCVRANSKNGKIGFLSCKKRLNVAVTRAKYCLIIIGQINTLNQDPNWRELIKDADKRNCLKNVTCLDEIKLVKKNASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TML6</accession>
    <name>A0AAV6TML6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_005231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002552">
        <property type="protein sequence ID" value="KAG8172595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TML6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="121"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8172595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="336" mass="38234" checksum="453D631B2FBB5EFF" modified="2024-11-27" version="1" fragment="single">VLERIVSEREEETLRQEEIKRHEEIRRQEEIKRQDKLKIEASMSKNDDGGEIISQNGGMQEQAQIGLQKLMHITNPSSIGVSTPHDTVHHIITKGPPVTARPRRLHPKSHDAVKAEFEFLLSQGIIRPSKSPWSSPLHVVPKQDSTVRPVGDYRRLNSVTEFDSYPIPHLHDFAHALHGKTIFSKLDIFKAFHQIPIAEQDIPKTAVTTPWGLYEYTRLCFGLVNAPQTFMRFMHEVLRGLPFCYVYLDDILCFSESHEEHKGHLRTIFERLQAHGLKLNISKCEFGVPELTFLGHLLTSQGLKPLPEKVDAVLQYKLPETIAALRIAGPGSSWAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNX6</accession>
    <name>A0AAV6TNX6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001895">
        <property type="protein sequence ID" value="KAG8173297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNX6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="326" mass="37173" checksum="286EBC5701000351" modified="2024-11-27" version="1">MVNYPKEMKSKLRKMTGVATDLMDLIDIYEGEPSITGEEEAIITALKGKTMFWKSTTILEDFCEQMRNSNMRLRQAQDLIPLMLSIINIKQAAVEYKLVLPAFAYTLTQSGNIDYRQYVKLQVHLNSHSMHIYSNESEDNLKYAICLSFLDAHMADQRLLPFFFKDLTPRKRDAMVKQVLLKGDLSEGEVKKVKIELPQLKAWSKMYKGERGLGGNEQASVCHSFAVTTKYNGVDFIVKDPTGITQQMNRWNNNKSLTGVLMEELQRLIETASRNVLKFGTQGIHSTVELDKDNSDLGLGSEIDLTGGRVMAYYSRTTTDDRWCHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTG4</accession>
    <name>A0AAV6TTG4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001118">
        <property type="protein sequence ID" value="KAG8174887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTG4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="188" mass="21646" checksum="DA1AD29938FB0001" modified="2024-11-27" version="1">MTVESFGRVCSSVSCSVDLPPSMIATDPVTAIYREDGTQFVHISPSKWWYPVVVLEYLLPYLDCDTTLTVSTSEDGYIPNDVVDVRFRMIQECPPLFAVTDCDDFHFLKYYMVKNNLVGNDAPLDRVENYLWKEDELYDIMIQERSNLVIITKDHCEKQIYLDDWDDGDMDPEVHTRIGHLGRGPGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTH3</accession>
    <name>A0AAV6TTH3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001048">
        <property type="protein sequence ID" value="KAG8175180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTH3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="123" mass="14273" checksum="74B6A8AC3613237E" modified="2024-11-27" version="1">MANKNSCLAYLPIAMAIVTLARYQLLVPYHYLSRLGYKAQKGEIVPKGFQKRRNELFWKPLLKSCWAMCGVLSIRQPNRSRMDEDDLSLESRVGYCGDMCCNWRCTSVEIQKYSICRKTKPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUZ2</accession>
    <name>A0AAV6TUZ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_018861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000983">
        <property type="protein sequence ID" value="KAG8175568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUZ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8175568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="310" mass="33266" checksum="44518F7FC1602D05" modified="2024-11-27" version="1">MLKCQICGLQFDNLPKLRTHKLSHQTTSSLTFPIPLTTTSTITVEAPNLSAPPTALSDATPAALFSLPPPPAKKSCVTVLPASHNDVTTTAICLDPPPPPHTMIDDQLSRPHAGPVSFPCPSCKAGPFANTKLRDLYIEFTHSRRSPRVFIQKEKIYTASRRTTPPIEQDPLCAVICSGPPKAPAFPKNPPHPGPRVSMPDPQVRSRCKTGRPRGRPPAARPPLNATLTQADSQDRIPGFSLSPQTISAQDPPKTPLPTPIAISTEAITHPTFDHPAFDATQVSRPASPSSSQVISPTSTQPEDRPQTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TW98</accession>
    <name>A0AAV6TW98_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000962">
        <property type="protein sequence ID" value="KAG8175697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TW98"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="9011" checksum="0169E62472E7E93F" modified="2024-11-27" version="1">MVESTDLLLKDLRASDLFTLMVKVFVPGCQFTPSTFTDLSQLNSISDLSSRKSSGITRSSLGLFEHHLRIVRPPRSIICIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWT5</accession>
    <name>A0AAV6TWT5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_021337</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000903">
        <property type="protein sequence ID" value="KAG8176234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWT5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="131"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="334"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8176234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="537" mass="59944" checksum="8F2D6BF2C00B4162" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZ23</accession>
    <name>A0AAV6TZ23_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000781">
        <property type="protein sequence ID" value="KAG8177402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZ23"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="8252" checksum="91C930BDA247D7CC" modified="2024-11-27" version="1">MKRLLPHPYETDCEDYELAWKKNNNTGPVSREMCELECAEKTFPSFSYFEGDIRVRPVWREECKHILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZ82</accession>
    <name>A0AAV6TZ82_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_028612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000862">
        <property type="protein sequence ID" value="KAG8176630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZ82"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="85"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8176630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24628" checksum="51F6B42E828B019E" modified="2024-11-27" version="1">MKETLYMHQPDGFDDGTSRLCLLKKCIYGLKQAPKNWFTKFSVFMNEIGFESLETDPYIFHRSTFSYNKCYPFDPLPLSHSAVPTGISPSGRISCISDLFGGAISDKEIFKRSVLPKVLEKGDVVLADKGFKIEEELNEIGVGLMQPLFLQNKIQFTERVENKVVSNLRVHVERAISRIKNFKYLILRVLYRTIPSTTLMKCFTLRHFSQISTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZG7</accession>
    <name>A0AAV6TZG7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000778">
        <property type="protein sequence ID" value="KAG8177480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZG7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="12"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8177480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="211" mass="23640" checksum="F929291C4794C9AC" modified="2024-11-27" version="1">MADVFTYSVEENLIAEIAKRPVLYQVKTKSFKDTVAKDNNWLEIEKVLNIKVEELKKRWKTIRDYYVRNSKKKPTGSQAKKKRVDERRTRSLSFLENYSLARSTYTNLPEDNGQCNVPESSSNSSKVPSFSEEEEFFSYTVVYDSPDAGEDTHPGEGSATQDPGEGTSTQDPGEGTSTQDPGEGTSTQDPGEETDSRSELRAGTEKGLSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0C0</accession>
    <name>A0AAV6U0C0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thrombospondin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_013626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000838">
        <property type="protein sequence ID" value="KAG8176949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0C0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005592">
        <property type="term" value="C:collagen type XI trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF878">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXVIII) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043406270" description="Thrombospondin-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="32"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Thrombospondin-like N-terminal" evidence="4">
        <location>
            <begin position="37"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8176949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="790" mass="81148" checksum="CA0A12B22C1B37DD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U196</accession>
    <name>A0AAV6U196_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000759">
        <property type="protein sequence ID" value="KAG8177703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U196"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="213" mass="23789" checksum="D4C2317CD2DFF9F7" modified="2024-11-27" version="1">MAAAYFSTSHALKNTSSENIASGNQLEDDLTPDDAASPNFYSPSSSADYSGFFDHFPDIGHFPEFGEIFRLSRTTTQRPPFRFPGYLREPFPDDDYKTDDTPPPRRRPPRPASSSSSRTKVSKAGGDIPMREKPVHRPAPKGSAHSSKTAFPKIFRFTADRVNLADFDSRKKVNENYLTLTKGDGLDSDGVRREGFLILHGGVFEIDSMKHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3F1</accession>
    <name>A0AAV6U3F1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000709">
        <property type="protein sequence ID" value="KAG8178246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3F1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="147" mass="15965" checksum="1283D21BDA4084A6" modified="2024-11-27" version="1">MTQLSSISNCDTTLSGETPNIENANEKILSPFNEFEGQGSGWIIDEILHLEVNTSVYNPLGAASYIPLPKGLLQTKSIMNIQDNACPCQNLCLFRNLLSGSSAITPFSTIPNTHPRNHGKILSNSRGGRVKQAHTRRSLTPCCAPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4C6</accession>
    <name>A0AAV6U4C6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000701">
        <property type="protein sequence ID" value="KAG8178355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4C6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7488" checksum="896182FD84A14CE3" modified="2024-11-27" version="1">MQILYSNHTVLAAVKLSGAERHAGDSYRFQALCQPPPPFALLPFTGAKICHLPPPKERKKGFPVLGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4S0</accession>
    <name>A0AAV6U4S0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">WD repeat-containing protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_026742</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000640">
        <property type="protein sequence ID" value="KAG8179280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4S0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000004">
        <property type="entry name" value="WD repeat-containing protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056158">
        <property type="entry name" value="Beta-prop_IFT121_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056159">
        <property type="entry name" value="Beta-prop_IFT121_TULP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057979">
        <property type="entry name" value="TPR_IFT121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057361">
        <property type="entry name" value="TPR_WDR35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017233">
        <property type="entry name" value="WDR35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056170">
        <property type="entry name" value="Znf_IFT121-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF5">
        <property type="entry name" value="LD29485P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23390">
        <property type="entry name" value="Beta-prop_WDR35_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24797">
        <property type="entry name" value="Beta-prop_WDR35_TULP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25768">
        <property type="entry name" value="TPR_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25170">
        <property type="entry name" value="TPR_WDR35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23145">
        <property type="entry name" value="Zf_2nd_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037536">
        <property type="entry name" value="WD_repeat_p35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT121/TULP4 N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121 second beta-propeller" evidence="13">
        <location>
            <begin position="332"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121 second beta-propeller" evidence="13">
        <location>
            <begin position="656"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="12">
        <location>
            <begin position="776"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like TPR repeats" evidence="15">
        <location>
            <begin position="1093"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like zinc finger" evidence="11">
        <location>
            <begin position="1222"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8179280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1269" mass="143565" checksum="C216150EB890D065" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5L6</accession>
    <name>A0AAV6U5L6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000627">
        <property type="protein sequence ID" value="KAG8179429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5L6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="758" mass="85921" checksum="3A00F38461E4094B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6W9</accession>
    <name>A0AAV6U6W9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibroblast growth factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_026316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000627">
        <property type="protein sequence ID" value="KAG8179416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6W9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23307">
        <property type="entry name" value="beta-trefoil_FGF8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043395022" description="Fibroblast growth factor" evidence="2">
        <location>
            <begin position="25"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8179416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25281" checksum="07EEC27D7100F820" modified="2024-11-27" version="1">MLIFRFLQIASLAYLCSLIKMVSCQSLSVGLEKGAPAILKNSQDIRRNYKLYNLCSGHHVQIIGKEINARGLSDNANANMSFISARSRHHLNAINIMGQKSGRYVCFNKRGKLIVRFNGRKKLCLFQEDFSKEHYTVLKSLYNPEWYVGFNKKGKPLKGSLHSKSKMESCFHFLKRDHSYGMEQYTPPGPKIKHPWKLKDLLTGGHRSRPQRKVPKTPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7F9</accession>
    <name>A0AAV6U7F9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein FAM195A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_000941</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCRIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000620">
        <property type="protein sequence ID" value="KAG8179540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7F9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029428">
        <property type="entry name" value="MCRIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14799">
        <property type="entry name" value="FAM195"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8179540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="16447" checksum="3C74D8E3951CCC10" modified="2024-11-27" version="1">MYTVSNRPYKLLANTRRGIAQKVDPLETSSGIREFVKCGTNVNMSMPRPVFHQVNGRKPQSPKAPQDIYPPQYNELIKYINDSWSGTQKEYELSKHSPDNKVPKVVYYQDDSDKSHLANFERFDLESFWGERFLKKIQQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7S2</accession>
    <name>A0AAV6U7S2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000611">
        <property type="protein sequence ID" value="KAG8179634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7S2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000006">
        <property type="entry name" value="uncharacterized protein C16orf52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037663">
        <property type="entry name" value="Mosmo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31186">
        <property type="entry name" value="MODULATOR OF SMOOTHENED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31186:SF1">
        <property type="entry name" value="MODULATOR OF SMOOTHENED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18800">
        <property type="entry name" value="Atthog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="167" mass="18467" checksum="4BC5AF257A1B4591" modified="2024-11-27" version="1">MDRLTVISGALFMSANCFAIISLILPDWIVSDVGGSTRLGLLRNCMTIYGRKQLCFAPSLQPEWMLSLICIIIGCICVSCTVGLLLLSHWNEQVVPYARWVGFSAMVLFCLAAVIFPMGFTMEEIGGEAYQLPSSHQVGLSYIFFVLALWITVISELFAGKVCMPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7S5</accession>
    <name>A0AAV6U7S5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000573">
        <property type="protein sequence ID" value="KAG8180239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7S5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8755" checksum="6D7D822BA17FAE77" modified="2024-11-27" version="1">MDSVNMKNQKLALNVKAFTKHSTAMYALQQFNPQRVLLIGFCQAVWPKPPFLPKMFETVQRQIQSATTPENPYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7Y1</accession>
    <name>A0AAV6U7Y1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Syndetin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_025262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000596">
        <property type="protein sequence ID" value="KAG8179938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7Y1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019514">
        <property type="entry name" value="Syndetin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040047">
        <property type="entry name" value="VPS50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258:SF0">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10474">
        <property type="entry name" value="Syndetin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="6">
        <location>
            <begin position="59"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Syndetin C-terminal" evidence="5">
        <location>
            <begin position="712"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8179938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="951" mass="110109" checksum="E28D47A998D02967" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDE8</accession>
    <name>A0AAV6UDE8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000474">
        <property type="protein sequence ID" value="KAG8182224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDE8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="10867" checksum="31F901E2C1C9C79A" modified="2024-11-27" version="1">MGLEDGSIISGFGEKEPMLNHSRVGGGAEESPAPPPVRNRRQSAIDRAARLVDITHHTVVHVSADVAVAGDVVRSPEKSGNGSQGTAFVAKIENAESPGNQNSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEK3</accession>
    <name>A0AAV6UEK3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000445">
        <property type="protein sequence ID" value="KAG8182827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEK3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="9416" checksum="9862C45334C7B3E4" modified="2024-11-27" version="1">MIRKKYKKDDVSDRSGIYDPYICYKDPDDWPSDTVADGKEKDYWIVKNRNIPPHCKVPEWIKMSYWTKNLKLESESKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFX0</accession>
    <name>A0AAV6UFX0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_018093</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000434">
        <property type="protein sequence ID" value="KAG8183047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFX0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="11" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8183047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="476" mass="53196" checksum="6C053BBF1A142C17" modified="2024-11-27" version="1">MMSAISGHYGLFEAIRYKRHRQAMLLAEAGIDVDCRNEKGQTPLIYTVVAVDDCSRSRAKLVKLFLEAGADPNAADWKGLTALMHASILGQAETVKPLLECVWTNPCVTDPNGNTALMYAASHGQQEVLAVFLSVFRNNLKSLQLHKRNTDGFTALHLAVRNRHDACSRLLTKEGQFFPTVIDEFPDPKDLDRDPTPTDNNEVLTIKQKYSPEDKRTTGTMTLDPEDLDLISDSYLSILECSVGDLPAWNFTHPFGLQTNKSTQVVSVDQRRPTPESRQTTPENVAKECEEVEEEEHEESEGTPETPLKIDDWPVIPLQLKPVPQKLLQPLMPIEVNNVEHSNGNTYQRKCLLKQGNRGMSGLRIKIHDARDISVSRIRNGQTVEESDGIISGSSIKSVHLKRNKQSNVSHEIVTNVLPLIPSKDSNLPPVRYSLRRAGSSKKESVCFPAAPLITVRADQTPREMEMFKKNVVVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGM7</accession>
    <name>A0AAV6UGM7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_028735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000441">
        <property type="protein sequence ID" value="KAG8182913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGM7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8182913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="155" mass="17241" checksum="32DB871DE5159FC5" modified="2024-11-27" version="1">MSSNPDCTVCGEEILVQDLLLCNGVCKSNYHSLCAGFTATQFKKFPNQKKTKWICTTCTTPEAVITKTSDGHVDFAVMLNNIHSQNTELKAFMTTKFDELTSSIKQNSSVIHDLMSTIAELQNSNLALQSKQSQLENENINTNKQIMNSNKKLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI47</accession>
    <name>A0AAV6UI47_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_006867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000396">
        <property type="protein sequence ID" value="KAG8183942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UI47"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029827">
        <property type="entry name" value="JDP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8183942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="159" mass="18531" checksum="4BCA7933B666849C" modified="2024-11-27" version="1">MDSILNYKKCEDDDFYKLLGCDESATVEQILTEYKALSLQCHPDKKPDDPEAVTRFQKIQKAKEILTNPDTRSLYDKWRACGFCMPFEKFLNLNKASHCTICSMHWASKKQKDLMLENSCVANESNKCSFGYESRMEQKASWQSDPGNDVLKRFRNYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJ11</accession>
    <name>A0AAV6UJ11_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000381">
        <property type="protein sequence ID" value="KAG8184257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJ11"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="8035" checksum="C3CECBC98FBFD32B" modified="2024-11-27" version="1">MHLVPPHKFNVPPKTLSKKTKASWEGGERTCSLCQCPHRELSSAGKTPLTWSRSRDESRVWFGWNVLDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJP0</accession>
    <name>A0AAV6UJP0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000376">
        <property type="protein sequence ID" value="KAG8184334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJP0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="11415" checksum="A9D08648532F988D" modified="2024-11-27" version="1">MFHYTDLLVVVFHYTDLLVVFHYTDLLVVFHYTDLLVVFHYTDLLVVFHYTDLLVVFHYTDLLVVFHYTDLLVVFHYTDLLVVFHYTDLLVVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMM6</accession>
    <name>A0AAV6UMM6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Steroid 21-hydroxylase</fullName>
            <ecNumber evidence="14">1.14.14.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">21-OHase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytochrome P-450c21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cytochrome P450 21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Cytochrome P450 XXI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cytochrome P450-C21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">JTE90_019745</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.16" evidence="14"/>
    <dbReference type="EMBL" id="JAFNEN010000334">
        <property type="protein sequence ID" value="KAG8185487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMM6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004509">
        <property type="term" value="F:steroid 21-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000049">
        <property type="entry name" value="steroid 21-hydroxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF403">
        <property type="entry name" value="CYTOCHROME P450 306A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 21 22" id="KW-0349">Heme</keyword>
    <keyword evidence="10 21 22" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 22" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG8185487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="508" mass="57102" checksum="4D095656391A597F" modified="2024-11-27" version="1">MFIISFDAFCGSATTATLVVFAAALIVARALTGGPKKNKGSLPYPPGPRCLPIFGYLLSIKKNCHLKLTQLGKEFGAVYQIFLGSKRVVVVSDPQLIRHAFKQQVFSGRPDTGLNTLLEGYGIINSGGALWHEQRQFLHSVLRDFGAKNMGPNKISLENNIQTQVSEFLSTLGATMGAAVHIRPHLARAVSNVVGSILMSVTFGQNDSGFKRLLYLIEEGFKLLTVAVPVNFMPALRYMPLMRYAYRKIESNRKETATYFAEVAEKHKKTLDPERVRDFVDAFFVEQQKAKSLNKQTYFSDEQLHQVMGDVFSAGLETVTSTLEWSVLFLVRHLDIQKRVQEEIDQVVGRDNKPELKDLPYMPYTEATILEVLRRANVVALGNSHATLEDTELGGYFIPKDTHVLPNLWAIHMDPNLWDSPEEFRPERFLVDGRVVKPSYFMPFSVGRRMCVGDSLTRMEVFLFLTNLLQKFDLRVPHGEEPPTVEGDTHASMTAKPFQICAVPRNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPY2</accession>
    <name>A0AAV6UPY2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000309">
        <property type="protein sequence ID" value="KAG8186209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPY2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8186209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="217" mass="24718" checksum="93DD911969233291" modified="2024-11-27" version="1">MQSVFMGVDHSEKLEIQKLKMDLKVCLFTLFLFTICYGKDTHISNQKPTSENPLSFVDMKQSENTTLTSKSNNSVYHYDDYDYDYNNRSSSSSQGVVIGVPIVSLLLLACCIYYCCRCRTQRNVGIVMTPHPPPPQIAPPTQIIIQQQAPPPMAGVAPPYPTQQHKPPPYDTQPMWNPPPQQQQYHQQAPPQHQYNQQMPTSYDNPNYGQPPVNPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UR29</accession>
    <name>A0AAV6UR29_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000308">
        <property type="protein sequence ID" value="KAG8186258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UR29"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16123">
        <property type="entry name" value="RA_RASSF7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033593">
        <property type="entry name" value="N-RASSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286:SF1">
        <property type="entry name" value="FI07216P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="19"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8186258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="400" mass="45746" checksum="12500EAC74013220" modified="2024-11-27" version="1">MGTEIPLWIGGLQKWVTGVTKQTTCEEVIKAVLTANSDKSKPHRDHKHYVIVERWHKVEKPLDPRSRLLKVWNTWGLEQCNVRFLLKRAHHAQTSGSTPRDIKSHRRKVSSKSTKTWHPRKLRSESEDDGSVAIDDDHFPATEEQLRNLISSQSDAISAQLRRLKDKDEEIEVIENGIHTQRMHQIGANYVLDTYLAESTSEGDGTAKNSDLPKTEDANKPTCDIFDHCIELYEKVLQICDQVHREELTIKDLTHQIQQSVQLKDKDGCRLVLDDHPEIAYATPERLEEILSRTKHDIERLLSINQTQQKTINQNEKTLVDCAKIIEEKHYYLQHLKSDLERLDKDNLRLQEEFSAVQVISMDKMSSCNVPENGDSNSDTGLSSLHSSSDDGVPVLDTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URQ2</accession>
    <name>A0AAV6URQ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000318">
        <property type="protein sequence ID" value="KAG8185971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URQ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="474" mass="52344" checksum="20723A96221109CB" modified="2024-11-27" version="1">MTATGMGPYSPSVYPKIEYGTVTSYSEGTSVVPSIGDMKKDCLEKELQVRLSGPVHKPEDIHISGANTRETLWINQAWRPPGEKNGIHDVKILNNINPGMEHNYISTNASDYAEVDTHNMTTFYKKELHAPCIPAPYATTTLINPSARQHSGSVHDKSSGSEMSKKSDKMYDMEARLIEDCVTEQLLEARNVMSPSSDSGSYTTDEYGLPIRRKRLRPVQKGSVLNWMEFIPPPPDHPPSGKASPNPLRSNPYAHRNMHLQMSNENNNPTHSPQVSSRSLQSGRQHPIWSNSPQGGSLTRSPPELGGNVAPYGSSPGVDRGVQSSLLSLASDPLSAKRRAGSLKNNNRGMIYHPLHAEPHDRVRYDNVMQMLQQQQQTTQLHPQQHSPTSSLNDEGEYAPGQCPAPSWTDVTDRSSTSSPRSSVASSSDGSVYTDSDFEKVVAKVNYQHLYRTPNHNKKIDTTNTSLLSPIHNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USY7</accession>
    <name>A0AAV6USY7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000270">
        <property type="protein sequence ID" value="KAG8187507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USY7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9787" checksum="72116368D894B7FD" modified="2024-11-27" version="1">MVESLPDNAACFIWVGVSCSCVRLKERSSGVRCITSNNPRSDLETVTHLPFLNNEDVQEKRIGAFKLKQLLKTNYVLKTYSIPKVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UT24</accession>
    <name>A0AAV6UT24_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000286">
        <property type="protein sequence ID" value="KAG8186883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UT24"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8186883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="270" mass="30971" checksum="14F20CF9EA45C043" modified="2024-11-27" version="1">MTHEEKVEVLKNKKCCYSCLKIGHRAKACRSKIQCICCGKKHYIIMCPDFKPTKNKHQDKAVEPEVLDQAKICGPIPHIKDQLDLSELRQKGITITDCSQEIRPIEILIRADMAGKLYTGNIVPLKSGITAMETYLGWVIMGKQANVYSKKSIDAVTSSLLSQNFNIENLWNLEALGTQDPYEPQNKIELENAVRENLIRSMTVEDGRYQDMQTVGVPDLDHLDEVDVTRRFRYQQKLREELRKRFRSEYLGQLTLAKSNTKSILRINGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UT62</accession>
    <name>A0AAV6UT62_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Microtubule-associated protein RP/EB family member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_005517</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000264">
        <property type="protein sequence ID" value="KAG8187665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UT62"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1430:FF:000005">
        <property type="entry name" value="Eb1, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000007">
        <property type="entry name" value="Microtubule-associated protein, RP/EB family, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="12">
        <location>
            <begin position="200"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8187665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32778" checksum="1F8C5D55BE92AF17" modified="2024-11-27" version="1">MGEREPIMCVNVYSTSGTSDNLSRHDMLNWVNECLQSQYKKIEELCSGAAYCQFMDMLFPGSISLKKVKFKTVLEHEYIQNFKLLQAAFKRVGADKHIPVDKLIKGRFQDNFEFLQWFKKFFDANYGGQDYDPLEARNGMMMGVDGRGGGGGGMTNKSGSSSRLAPNVSVNKSIARAAPSPRVATQPPSRIAAQRVTNRLAGGDHQRMEELTGQLSEMKMTVDGLERERDFYYGKLRDIEVLCQEQEMSEEKQTFIEQILEILYQTEDGFAVPDDAPEDGLPSQNDEDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTQ7</accession>
    <name>A0AAV6UTQ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NGFI-A-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_021782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000295">
        <property type="protein sequence ID" value="KAG8186631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTQ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.2010:FF:000001">
        <property type="entry name" value="NGFI-A-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.2010">
        <property type="entry name" value="NAB conserved domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006989">
        <property type="entry name" value="NAB_co-repressor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039040">
        <property type="entry name" value="NAB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006988">
        <property type="entry name" value="Nab_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038398">
        <property type="entry name" value="NCD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12623">
        <property type="entry name" value="NGFI-A BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12623:SF10">
        <property type="entry name" value="NGFI-A-BINDING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04905">
        <property type="entry name" value="NCD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04904">
        <property type="entry name" value="SAM_NCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Nab N-terminal" evidence="8">
        <location>
            <begin position="228"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="NAB co-repressor" evidence="9">
        <location>
            <begin position="443"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="349"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="867"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="906"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="880"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="915"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8186631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="925" mass="101407" checksum="82E3B79714CD37D3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU33</accession>
    <name>A0AAV6UU33_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000274">
        <property type="protein sequence ID" value="KAG8187322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU33"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="9174" checksum="916013F2802EEF3E" modified="2024-11-27" version="1">MSTNQLSKDSVVNASTRLMTLIYAGCLPTKAITTMCTLVEPLSRLVPIQQFMESFTKRRSADELDKDLDGGSPTSVRRRPSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUX2</accession>
    <name>A0AAV6UUX2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_009520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000272">
        <property type="protein sequence ID" value="KAG8187448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUX2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8187448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="288" mass="33069" checksum="3D7FFCF1FE58E106" modified="2024-11-27" version="1">MSYTIIERGSPNSLGYRIFYTDENGPISPFHDIPLLVDKENRIYNMVVEVPRWTNAKMEIATKEPLNPIKQDTKKGNLRYVHNCFPHHGYIWNYGALPQTWEDPNHTDESTSCKGDNDPIDVCEIGFRVAKRGDVLQVKILGVMALIDEGETDWKLIAIDINDPLAEELNDIEDVEKHMPGLLRATHEWFRIYKMPAGNPENKFAFNGEPKNREFAEKIIEETHQFWKKLIKNETDANGLDCSTVTIEDSPNKINVINALTILQQTEEPGSPQDVDPIVDKWHFVQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWE8</accession>
    <name>A0AAV6UWE8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000259">
        <property type="protein sequence ID" value="KAG8187790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWE8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="178" mass="20737" checksum="02BB56832DB9F61B" modified="2024-11-27" version="1">MDVWVENRSAVIQCLSRAVTLDHSGDCEAAFGKYLESLNALSLYLKEMHVALGFHKTVEKHCEITRVLSMIRECTDRVQIIVDTNSANSTKVVTVRRREENSRRDSISNDVVTPPSQKFPPFEKLQADNMRIIKQYQWRCERTNNYREKTNIRLELERKLAENAVIAKQKYNTVSFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWZ6</accession>
    <name>A0AAV6UWZ6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000228">
        <property type="protein sequence ID" value="KAG8188860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWZ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031751">
        <property type="entry name" value="DUF4735"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33539">
        <property type="entry name" value="UPF0764 PROTEIN C16ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33539:SF1">
        <property type="entry name" value="UPF0764 PROTEIN C16ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15882">
        <property type="entry name" value="DUF4735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044011965" evidence="1">
        <location>
            <begin position="18"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="316" mass="36062" checksum="6776DF7A17E90DCC" modified="2024-11-27" version="1">MGAVVFVLLCAFCGVQGGLIDALGKGLDFMEANIGDINLDAVLGTRLVEEQLTSYFDLEADVMPHDIYNRIVALRDKARFISNEGMSQVAKNDPQYFQALGQVMAPSVRPVWYPSQRLSSEAVIVPLPCSRSAFNETDSDTCLQEIVGTERQKNTCMLSSRCVQKMTSPGQRDYMLTHQVLYWQLVEMRGCRESIPHRIRTNLCSNVMRDAKRIAEAQFPRNHRDLFMEQVGLCGMWGFRDFYKDQWVDTFLSWQQESGCYNDRAKWHCADNLTKDVQPRMKRREKIHKDGCLSHKTAVALLAMAVSIRFELEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UX65</accession>
    <name>A0AAV6UX65_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">63 kDa sperm flagellar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_019287</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000239">
        <property type="protein sequence ID" value="KAG8188383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UX65"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF89">
        <property type="entry name" value="COMPLEMENT COMPONENT C1Q RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="744"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="8">
        <location>
            <begin position="532"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="656"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="705"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8188383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="915" mass="100976" checksum="3E8A2222C1386BCD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYK3</accession>
    <name>A0AAV6UYK3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000227">
        <property type="protein sequence ID" value="KAG8188913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYK3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="175" mass="19526" checksum="99E204C84F608E4C" modified="2024-11-27" version="1">MQVSNWMHFVLIGLSNRETVYRFDKAEALLEPLCLLVPFPPIKSELLSSRGNKGSAADTTRDIRRECPKCTLTYTSDKSEEMTIRLHHERIETFAKTGRLSLENLNSSPLFFSGFSPAKRNAGDHLPERGLYLIAARAGSESERGGCRDSEQKFYCTSNGCFGAHKVALSFSSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYM3</accession>
    <name>A0AAV6UYM3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000229">
        <property type="protein sequence ID" value="KAG8188828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYM3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="13796" checksum="D97BA45E1B2A9CC0" modified="2024-11-27" version="1">MTIHPTNSRICLATLSQYLSLKIAHVLYGSVRGLIKCRKGDPEAASHASCMAPIKIILHNHIYLSRQLCNSPKFYLSRQLCNSPRLKLCRQLCKNPPKNYLITCSHLFATPSTATHQTQEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0I0</accession>
    <name>A0AAV6V0I0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_021859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000217">
        <property type="protein sequence ID" value="KAG8189356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0I0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="90"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8189356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="395" mass="44239" checksum="550FE82439B71291" modified="2024-11-27" version="1">MSMLRKNYKQCNNRDDEDELFESQSDFRTPGRETTKDRCKVCTEHLAIVAFVLILLAALAVTAIIVLIYLPDILGKTRTAEANDPSDNLSPVAQTNCGAFVGVEEGKAFAFKGIPYAQPPVGPLRWKKPQALWSNTSWCRSKNHFKAHTFGSACFQLNPFLKQFEGQEDCLYLNVWTPTLNPEANLEVMVWIHGGFLQFGSGHQKGLSPNGHLASHLNVVFVSFNYRLHVLGYLALDSLFTNLMEDSRGNYGTWDQLVAMEWIRDNILYFGGDPKKVTVFGPDGGAASILVMMTSPKFRSTFRSAWLLGPAMVFNRSFSDSSHHNKGHFMEKTGCAADTQCLRKLTPKEVTGTYVWNDDPSFRIRDQNDLPIQGILPEQLVVVDGKCENCIDLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0Y1</accession>
    <name>A0AAV6V0Y1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Knottins-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_018492</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000208">
        <property type="protein sequence ID" value="KAG8189643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0Y1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003614">
        <property type="entry name" value="Knottins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00505">
        <property type="entry name" value="Knot1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043854473" description="Knottins-like domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Knottins-like" evidence="4">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Knottins-like" evidence="4">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Knottins-like" evidence="4">
        <location>
            <begin position="199"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Knottins-like" evidence="4">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Knottins-like" evidence="4">
        <location>
            <begin position="301"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Knottins-like" evidence="4">
        <location>
            <begin position="432"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8189643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="479" mass="53563" checksum="9E7AD52D274A45A7" modified="2024-11-27" version="1">MNEYFLNFCFIFAIGFQVAHGQDEECGVNEVYAECVNACNTCHPTGRICNLGCVAGCTCKPDHSRNREGLCIPTKLCNDSSEAIGDDTTSTTSGFWCTNSTCKRTCRRRGFTNGHCTWHIRPRCQCNEIKVSNNSLETSTGGVPETNSSAALEYFCTNRDCRQTCRAQGFKDGRCIRHIRPYCQCIRHASLAIDREGPPIEGGHRNSGGCPKVQRCSRFCQNRGFPVGTCFSPGYRGCRCLKYSDSNEESEGCPSLRRCAQRCRLNGFSGGTCHGHTCRCYRDRREDADFVPPPGRNFDSIRDIVVEVPEHCTSRKCEGLCSNKGYSQARCVGRNFCKCFSKAQAIVDYDGDEEHHRNSGSYCPDVHRCARSCVIRQFVGGVCVGRRRQTCRCISEEEAGGISRYRRCIPGQEVGIPPTPNEEVIQPSFPNEREFDIDDSEGCPNRERCRLSCRRRHFIHGVCRGNGLRTCVCEGPIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V447</accession>
    <name>A0AAV6V447_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_002595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000178">
        <property type="protein sequence ID" value="KAG8190640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V447"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF7">
        <property type="entry name" value="RE45222P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043910818" description="Spaetzle domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8190640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="59718" checksum="3B7091C116DEDB83" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4Z4</accession>
    <name>A0AAV6V4Z4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000176">
        <property type="protein sequence ID" value="KAG8190696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4Z4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="95" mass="10656" checksum="9A46CD0D603905A9" modified="2024-11-27" version="1">MNAKNPWWIRDQKPSSIQIDVLSAGGIVCAAILHASPSPELTRPLTNERREVSDQSGMRRKPGILLASVAFATEEVKYRCARSYWNANGWNKSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V598</accession>
    <name>A0AAV6V598_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000167">
        <property type="protein sequence ID" value="KAG8191098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V598"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10952" checksum="B40F1FEAFCDCB277" modified="2024-11-27" version="1">MKRLISPLQSVLRTLIRIPPELYQLSYEQFQFQEGVGERYARSHGRNIIRNIPGFSKHIKEMNRGHELIRTERRKNENTRVLLPVLDARRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5P6</accession>
    <name>A0AAV6V5P6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_007747</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000149">
        <property type="protein sequence ID" value="KAG8191952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5P6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="556"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="829"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8191952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1073" mass="120505" checksum="4284DA451F7B8DD9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5R2</accession>
    <name>A0AAV6V5R2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000148">
        <property type="protein sequence ID" value="KAG8191967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5R2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="11065" checksum="1E6C18E872B00213" modified="2024-11-27" version="1">MITEQKPTSRLLYQSKLTISCNSHSIPQTPLKIVCNLQEYLATFESVFFSYEWMRWIPRPSCSIIIIFGNPLGSVRPSAVSLSVLATVRCWSDRLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V728</accession>
    <name>A0AAV6V728_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000146">
        <property type="protein sequence ID" value="KAG8192036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V728"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="671" mass="74758" checksum="A081FC1772F9875C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VA84</accession>
    <name>A0AAV6VA84_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VA84"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="120" mass="12957" checksum="629FC99245B9FA3F" modified="2024-11-27" version="1">MNLICSVVAPTILHASVSLTPSMDSIIAASPSSETSGEVVMREWDCHRQDPPSGGREEMNGLRGLVSCPSEVEKKQPLYIVIAMSGEVVMRESKWDCQRQDPPPGGSEEVEMDGLKGLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAT7</accession>
    <name>A0AAV6VAT7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000135">
        <property type="protein sequence ID" value="KAG8192776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAT7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="175" mass="19692" checksum="7DA05F46F0709788" modified="2024-11-27" version="1">MTNKGAVIRISRTMSGLIGVRFSDTIWVNRPVMGIERESVLFKVMPYSALCGRGIRSSGRREVTEYPKASHDHGLFNKCLSMDLLLNTTQTSFAHLTSSRPHPKRRLPPDNKKHRPKKGVWILRGRRKKNPPKISGLVSSEKAWRVNSGVFDSAAYVCFGINGYTCCLRGRFGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBH9</accession>
    <name>A0AAV6VBH9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Neurexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_012197</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000123">
        <property type="protein sequence ID" value="KAG8193397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000015">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000029">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF89">
        <property type="entry name" value="NEUREXIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1554"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="23"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="206"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="249"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="461"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="643"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="683"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="868"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1065"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="1106"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1294"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1324"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1508"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1294"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1352"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1394"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1512"/>
            <end position="1521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8193397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1651" mass="179606" checksum="973D23789076BB44" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBJ1</accession>
    <name>A0AAV6VBJ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_028163</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000132">
        <property type="protein sequence ID" value="KAG8193051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBJ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15137">
        <property type="entry name" value="7tmA_Relaxin_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000023">
        <property type="entry name" value="Relaxin family peptide receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008112">
        <property type="entry name" value="Relaxin_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF80">
        <property type="entry name" value="FI21465P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01739">
        <property type="entry name" value="RELAXINR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="14 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043484865" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="19">
        <location>
            <begin position="20"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="590"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="20">
        <location>
            <begin position="431"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="730"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8193051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="759" mass="85976" checksum="D9401EFCC57ADEDE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBT5</accession>
    <name>A0AAV6VBT5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000130">
        <property type="protein sequence ID" value="KAG8193106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBT5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="137" mass="15516" checksum="179BEDCF1AC6DCD2" modified="2024-11-27" version="1">MVTKYPLVRRIHWWKEDKLAAMANCGPILQFLFLLLCCKLACCSPIDEDRRIFNKINANAFIDRLIHYTPELRLMLNGFLRYQNIAKRPEDSSNRSKSQADDPLATILATGFLGSRGKKDDGDELPVFANGFPAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF74</accession>
    <name>A0AAV6VF74_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_028022</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000100">
        <property type="protein sequence ID" value="KAG8194708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VF74"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001250">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DDX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8194708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="820" mass="92289" checksum="EF6579E46A1DE9FB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VG40</accession>
    <name>A0AAV6VG40_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000087">
        <property type="protein sequence ID" value="KAG8195457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VG40"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="132" mass="14955" checksum="9D979D4F49E9685B" modified="2024-11-27" version="1">MILINLKRRSWTLLKLDDLANQFKLMKQEINTRFENFENKEIIHNIAASYASVTKTNNKSEIVAPSDLKARSINALPNAESHVRKLNENKTVISGTGNTSKLLSATRFPKRSAVFVSRLGQMDVLFQDFMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHG8</accession>
    <name>A0AAV6VHG8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHG8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8711" checksum="971B1A220589D63D" modified="2024-11-27" version="1">MLPLHLRFASGSGERNGSDSQPDVWRRSHHQRMVVSCSQWTMHSGQSTGVGFQEMKNARFFLLFESGSKLFAYFGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VI03</accession>
    <name>A0AAV6VI03_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VI03"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="159" mass="16728" checksum="04BC0F5A47EF3DD3" modified="2024-11-27" version="1">MLLLRYQQKRSADAEEGGCGVSRHSSAAGEIRRKMAGGELHSEGRRAATRSTLVCIFVCGTALLSLGIGVLCTGLYLPVHDPAPWLVAGPTCIVLGVLVLLLSVEIILKLRKISAAAEPQQSPPPPKKGVAMAPPPPVVVHPATPQILDPAALEVVQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIX8</accession>
    <name>A0AAV6VIX8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIX8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="196" mass="22802" checksum="FFB8E180699E470D" modified="2024-11-27" version="1">MEDHFWIDPLQLEKNAVDNTDSGGRRSRSVERSASEETLFKEDIIKAFLRSAQVAYGQAENVKNHMVDVQYPHLEPDSLSSHQYDFLKFSEEAIENTDTNLLEVLRHLQKFAVTLYQILKETEEVETGSDYHLLLQDSKDKMVQLLCDIMLAIEAFGMTPFEDIAYDTLPQHMKDKKRLSNKSLRDYLKKLERVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJB1</accession>
    <name>A0AAV6VJB1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_007938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJB1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8196213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="571" mass="65866" checksum="30A3005EA70C9187" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJW8</accession>
    <name>A0AAV6VJW8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Scaffold protein salvador</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_014512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000064">
        <property type="protein sequence ID" value="KAG8196780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJW8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21433">
        <property type="entry name" value="SARAH_Sav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000035">
        <property type="entry name" value="Salvador homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030030">
        <property type="entry name" value="Sav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522:SF2">
        <property type="entry name" value="PROTEIN SALVADOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522">
        <property type="entry name" value="SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="455"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="5">
        <location>
            <begin position="551"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8196780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="68449" checksum="529B285E5503DCA3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKE4</accession>
    <name>A0AAV6VKE4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000059">
        <property type="protein sequence ID" value="KAG8197107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKE4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="350" mass="40694" checksum="08D6195706278E02" modified="2024-11-27" version="1">MASTFFNKRCNVCNRPFQTFFDDERVTTFTLDTIQGEVHYVYKKNQWVSWICENMNFREEIGDVKDENNVTVCDDTSVVLKSDNAKNNNGNDTNANYFDKIVEFKEGSDEDTENEGHFYVESTEDKNYENDVVESSDAKDMGAERLNVVSNYSEIQELIPKDYEANNSLNNSLVGFVSGHVTRVRCSKTSEVKESLIKDEYSDEKKKLVIVDKNKNVQYCKIRSSSIEDDASYENDLEVVNVLTDIKYDRFENNIDDSEDVGGNNFDYETLNKYPENVNNYYKYGINSNNCLSEEKELQSNDPLLQEGQEIKIHTKRRISINKPMTVSDFKTYLAQQREKKKRWFFQGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VL77</accession>
    <name>A0AAV6VL77_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000056">
        <property type="protein sequence ID" value="KAG8197344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VL77"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF10">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24370" checksum="C2BFB5D9F27358FA" modified="2024-11-27" version="1">MTHPVIHHVVMCVLNADDTFDRLRKFGFKLFAKRETPLCKELVLRIGQVNFIITERKDDASPYTKYSDGSKIRSEHFTTFCCENQENHEIDSVFNVAFEVRDIQLVVNRIKSGGGSANVIQPITTLTDTNGEMKYCLIKSVCGNVVHCILQKSSYHGFLVGYEVMEDAFEDDSETQYGINFVDHVTLACHSGHSEEILRFYEMCFGMKKFSIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLI8</accession>
    <name>A0AAV6VLI8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000067">
        <property type="protein sequence ID" value="KAG8196593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLI8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="468" mass="53342" checksum="2AD2A581FCEE29F5" modified="2024-11-27" version="1">MADSKPYKYCHHCGNRFSNESLTDHERQCKNNERQKVQDSFDFKTKKHDAKTMSPEDNDRVKEMKEMPKTTLEEELIKETESKMNQKKSGKIPSPQTQLLNETEQLREKEKDKLASKKDSTEYSSDDLSQGGTEVKRVTPTKVSSSRPKKIDPITGRKKPYLSQDKDNQDNKAFPNPRKVSEDSKPSKVAKKTQVDANEDTEKKSTSSPKKEGSRGKESDQSKDNKATQNSSKVSDSLKSEPSPKYSSISCNCSKELTSNSKVAKNDEISQTPKPRKKSESKASKTHNPAKKISKKVSSSSPKKIDPITGRKKSHQSQDKDNKDNKAFPNPRKVSEDSKLQPSPRYSSRSCECARKYSRKDLNNAELVDEKNKLKVKSTQGDKSFPIMNKFDKSPDKKKVNSKEIAQKREGLEKDNEKSKKDALAKIDKQFLCKYCGRTLVAEDVPTHERLCERRPYKEHELKVERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM68</accession>
    <name>A0AAV6VM68_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Myelin regulatory factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_027547</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM68"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051577">
        <property type="entry name" value="MRF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025719">
        <property type="entry name" value="MYRF_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026932">
        <property type="entry name" value="MYRF_ICA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030392">
        <property type="entry name" value="S74_ICA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029:SF18">
        <property type="entry name" value="MYELIN REGULATORY FACTOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13888">
        <property type="entry name" value="MRF_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13887">
        <property type="entry name" value="MYRF_ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13884">
        <property type="entry name" value="Peptidase_S74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51688">
        <property type="entry name" value="ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="751"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="NDT80" evidence="10">
        <location>
            <begin position="268"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S74" evidence="11">
        <location>
            <begin position="571"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="7">
        <location>
            <begin position="268"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="954"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="954"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8196833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1210" mass="135081" checksum="5B7FB04E06D4CEC1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM73</accession>
    <name>A0AAV6VM73_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_011301</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000058">
        <property type="protein sequence ID" value="KAG8197138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM73"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22209">
        <property type="entry name" value="EMC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043327916" description="ER membrane protein complex subunit 10" evidence="10">
        <location>
            <begin position="24"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8197138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="232" mass="25742" checksum="782804BE494230BE" modified="2024-11-27" version="1">MFFRVVARSIYIICIFLITHCSCLIDDELEGHVLFYIYHSLEPSTSAPVYEQRGTVTYTTSRNEALYTDDSLLTTEKIEKLQKLAVTDDIYRVKLSTKPGDSESSIFSFTKACGIYESGLTDILSITLDQTGNPVGVAISASPPHCMGEEVSNARLLNFNTTVNFVSLTNAPAPDTLTYIQRLEQEKAEKARGEQGDNRSFLTKYWMYIVPFVIFLFISGASSPEGQGAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMU3</accession>
    <name>A0AAV6VMU3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_006885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000043">
        <property type="protein sequence ID" value="KAG8198132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMU3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12394">
        <property type="entry name" value="RRM1_RBM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12395">
        <property type="entry name" value="RRM2_RBM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034221">
        <property type="entry name" value="RBM34_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF56">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="284"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="389"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="501"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8198132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="529" mass="59812" checksum="1BC38395C56EF21E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNT5</accession>
    <name>A0AAV6VNT5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNT5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="127" mass="14864" checksum="E5087091DC0400EA" modified="2024-11-27" version="1">MAEDRYPQYRRKSLETGGFSARLKAKRKKIGNTKYGDGYGSDEEHKQAYLRLLEWETLQEGDQSVQCKYEILVLPCPHYANSECQCCLAMLLKIFKSNKIFCTHQMSKDVFFTIFNAFGERSKNLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP65</accession>
    <name>A0AAV6VP65_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Superoxide dismutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP65"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043529430" description="Superoxide dismutase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="67360" checksum="912CE10DECD6D98C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPP1</accession>
    <name>A0AAV6VPP1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_026459</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tenascin family. Teneurin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000001">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000013">
        <property type="entry name" value="Teneurin transmembrane protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000033">
        <property type="entry name" value="teneurin-a isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057627">
        <property type="entry name" value="FN-plug_TEN1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056822">
        <property type="entry name" value="TEN_NHL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056820">
        <property type="entry name" value="TEN_TTR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028916">
        <property type="entry name" value="Tox-GHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF69">
        <property type="entry name" value="TENEURIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24329">
        <property type="entry name" value="FN-plug_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25021">
        <property type="entry name" value="TEN_NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23538">
        <property type="entry name" value="Teneurin_ABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15636">
        <property type="entry name" value="Tox-GHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25020">
        <property type="entry name" value="TTR_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="268"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8198559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2244" mass="253859" checksum="26F2747C5A10CC28" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPZ7</accession>
    <name>A0AAV6VPZ7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000043">
        <property type="protein sequence ID" value="KAG8198185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPZ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="85" mass="9563" checksum="2E07CCE53082C717" modified="2024-11-27" version="1">MLHMHFMQRHVLTGDGTVTDTVSCHSQCALLQNFPVTVVGYTLGDDVIMTSFVDISQFLYCGLCCRQGLFTRGFLQLTGMKRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQ86</accession>
    <name>A0AAV6VQ86_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">2-oxoisovalerate dehydrogenase subunit beta, mitochondrial</fullName>
            <ecNumber evidence="3">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Branched-chain alpha-keto acid dehydrogenase E1 component beta chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_007079</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterotetramer of 2 alpha/BCKDHA and 2 beta chains/BCKDHB that forms the branched-chain alpha-keto acid decarboxylase (E1) component of the BCKD complex. The branched-chain alpha-ketoacid dehydrogenase is a large complex composed of three major building blocks E1, E2 and E3. It is organized around E2, a 24-meric cubic core composed of DBT, to which are associated 6 to 12 copies of E1, and approximately 6 copies of the dehydrogenase E3, a DLD dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000035">
        <property type="protein sequence ID" value="KAG8198769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQ86"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000004">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit beta 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="12">
        <location>
            <begin position="56"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8198769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="377" mass="41578" checksum="0A1906607215C2D0" modified="2024-11-27" version="1">MALKHLSSSNFLKYFSSIRNKKFLKIKESNKLSYRCSHFTYVPDTVSSTDGETARMNLFQSVTNAMDIALGTDPSAVIFGEDVAFGGVFRCTVGLQDKYGRDRVFNSPLCEQGIVGFGVGLAIAGATPIAEIQFADYIFPAFDQIVNEASKLRFRSGNEFNCGGLTIRAPYGAVGHGALYHSQSPEAFFAHIPGVKVVIPRGPLQAKGLLLSCIRDKNPCIFFEPKILYRMAVEQVPLKDYTLPLSKAEILTEGDDVTVIGWGTQVHVLREVCQLAQDKLNVSCELIDLVTILPWDKETVINSVKKTGRVLVAHEAPLTGGFGAEIAATIQNECFLNLEAPIQRVTGHDAPFSHVFEPFYIPSKWRCFDAVKKLINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQM9</accession>
    <name>A0AAV6VQM9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000043">
        <property type="protein sequence ID" value="KAG8198152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQM9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8546" checksum="1AC55EC81F69CC21" modified="2024-11-27" version="1">MFHELFSFFANIDSDDQWERGLPSHRNTFGPCTKPSEHPKRTAFPIIINHAVANAAPRISRIHDTHNPPSQQSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSE8</accession>
    <name>A0AAV6VSE8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSE8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="8192" checksum="ABEB0EF0D464397E" modified="2024-11-27" version="1">MCVCVSKYRSIVLFEVFRLSFIEIFKNTEAGTLKVLLLKFLLSLCYVLEQKETFWPSAKCTFVHIVLIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSH3</accession>
    <name>A0AAV6VSH3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_009480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSH3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000064">
        <property type="entry name" value="Septin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="10">
        <location>
            <begin position="31"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8199649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="373" mass="43385" checksum="B05B0AC2CAB2A3EC" modified="2024-11-27" version="1">MNEWGSLSSMDGGEIGFATLPDLVHRKSVKKGFDFTLIVVGDTGLGKSTLINSLFLTDLYKDRKNFSVEERVDRTVDIEKITMDIEEKGVKLRLTVVDTPGFGDAINCEENWKTIERYIDDQFNQFFKDESGLNRKNIVDNRVHCCLYFISPYGHGLRQLDVEFMKRLHQKVNIVPIIAKADTLTPIEIRKLKETILKEIEENQIRIYQLPECDSDEDEEFKQQDKELKDSVPFAVIGSTQIVEINGRKVRGRLYPWGIVEVENPKHSDFLKLRTFLISTHMQDLKDVTRDVHYEGYRAQYITKISQQAARERNKLRRDSGPNFEAVSETDRLLQQKEEEIRKMQDMLQQMQQKLRAAGNEEGPKEEAREMNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTA0</accession>
    <name>A0AAV6VTA0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">E3 SUMO-protein ligase PIAS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_001805</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000033">
        <property type="protein sequence ID" value="KAG8199008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTA0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.30:FF:000001">
        <property type="entry name" value="E3 SUMO-protein ligase PIAS2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.780:FF:000001">
        <property type="entry name" value="E3 SUMO-protein ligase PIAS2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF94">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="12">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="PINIT" evidence="14">
        <location>
            <begin position="132"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="13">
        <location>
            <begin position="337"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="100"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8199008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="70429" checksum="4F83A5CE949DC10C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTG3</accession>
    <name>A0AAV6VTG3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000028">
        <property type="protein sequence ID" value="KAG8199328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTG3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9650" checksum="B18CE330CE8EDA34" modified="2024-11-27" version="1">MVLYVTKSIRSTDKARLLKLMCRLANSMIPAASRGNGGPILEFIRSANNFSVERREGTKGRGVGKGQGYPVGTSLFFTLALELASPSCKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTK5</accession>
    <name>A0AAV6VTK5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTK5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8165" checksum="B3A1FC2CB96F884D" modified="2024-11-27" version="1">MKVPPPPPCAVLSSRLYLDTPRAVLVIVHDKNQNRKSKQVDGIPCQDGGCNLTTTSPGKVSAPTFLSSNNAYLKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUZ3</accession>
    <name>A0AAV6VUZ3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Disintegrin and metalloproteinase domain-containing protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_000555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUZ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF2">
        <property type="entry name" value="KUZBANIAN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="4">
        <location>
            <begin position="162"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="3">
        <location>
            <begin position="396"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8200475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="71604" checksum="CF2C036766702E4E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVY6</accession>
    <name>A0AAV6VVY6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_006211</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000022">
        <property type="protein sequence ID" value="KAG8199966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVY6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19031">
        <property type="entry name" value="LGIC_ECD_nAChR_proto_alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000013">
        <property type="entry name" value="Acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000012">
        <property type="entry name" value="Acetylcholine receptor subunit alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000022">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit alpha4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="79"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="300"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8199966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="563" mass="63731" checksum="FD09BE55343EBCB4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VW53</accession>
    <name>A0AAV6VW53_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_022155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000025">
        <property type="protein sequence ID" value="KAG8199706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VW53"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043697832" evidence="2">
        <location>
            <begin position="17"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8199706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="222" mass="23471" checksum="1B9AAE0BE1B18552" modified="2024-11-27" version="1">MKVFAVLALFVAVAVAEDMMSAESYPVATYHQGPAHAASSAGHAYGAHGQRASGYGAYGQSHYGDHGRYSDKAHKAQGHHNVGGYKAHDAHGAQGSSYGKYRNVGAYAQDKGTGYEKAYAYDKKAGHHAIVADHGAHASNYGVRDRNAHHNVGAYANAGHNRYGSHNKYGGAAHGVSAHDNSAYGRYGSAHAQQSHHAPAVSYHHAPAHYAPAPAHQGYSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWF9</accession>
    <name>A0AAV6VWF9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="5 14">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_018924</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Polyol metabolism; glycerol degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="5 14"/>
    <dbReference type="EMBL" id="JAFNEN010000019">
        <property type="protein sequence ID" value="KAG8200139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWF9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="619"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="655"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8200139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="719" mass="80075" checksum="A39837D1ABAA3EC2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXL6</accession>
    <name>A0AAV6VXL6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_016876</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000006">
        <property type="protein sequence ID" value="KAG8201405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXL6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="28"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8201405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="134" mass="15263" checksum="0A86472D3398D728" modified="2024-11-27" version="1">MEKGLTSFGKFDFSKMGRIFLEHIGGSRMFSCAGCDTILTNRNELISTRFTGATGRAFLFNKVVNLTYSEVQDRVMLTGRHMVRDVSCKNCEAKLGWIYEFATEENQRYKEGRVILERALVTESDGLDEYVPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYB8</accession>
    <name>A0AAV6VYB8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_022326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chloride channel CLIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYB8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053823">
        <property type="entry name" value="CLIC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43920:SF5">
        <property type="entry name" value="CHLORIDE INTRACELLULAR CHANNEL CLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43920">
        <property type="entry name" value="CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22441">
        <property type="entry name" value="CLIC-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="6">
        <location>
            <begin position="93"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8200716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="539" mass="61832" checksum="226E5CD680DF929C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W028</accession>
    <name>A0AAV6W028_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U3 small nucleolar RNA-associated protein 15 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_012767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W028"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="160"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="9">
        <location>
            <begin position="342"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8201703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="506" mass="57298" checksum="E6F03FFC2F3830EC" modified="2024-11-27" version="1">MTDFKSLEIYKFPRPDAQITEDNLYWKNFAFPCAFKEYGAIDCVDYSPEAPHHVAVTCSAKVQIYDTSNSTQLCSMSRFKKQAYGGVFRKDGKLLVAGSEDGFLRLFEVEGHRQLRVFKGHKAATHRCRFTSDGIHLLSFSDDKTVGLWDIPTETRLMTYDEHKDYIRAGAVSQSSQDLFISGSYDHTVKMYDTRTNKSVFTMDHGTPVEAVLQFPVGGLFISAGGMSLKVWDPVAGRLLAEVQQHHKTITSLCFASNGRRIMSGSLDRHVKIYDVMTYDVVHTLNYDSPILSVGAAPDDMSIGIGMTDGIFSLQHKKPEKTHKEVKPKNKRFRHYHSYSTDFKPANDDVVVSERKKKISTKYEKHLKKFESSKALDVVLRERVQMNSPEVTVSLMMELIRRGSIRAAMAAREGESLALLIKFIEKYIGDPRFQRVLMDVAFILLELYGPKLGDPQLLKRFQKLGQIIENQHATMKQQLEISGVIQGILAAKYSMTQDTSPDEIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W0W7</accession>
    <name>A0AAV6W0W7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ankyrin repeat family A protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_016870</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000006">
        <property type="protein sequence ID" value="KAG8201399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W0W7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="11" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8201399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24716" checksum="C07C027B52E100D0" modified="2024-11-27" version="1">MYVQVLIKDQSIHWETPCTESPLENAEDGNRSAFTPYKPVTVLTNLQRGNIQTEGPAVLPERSVHQLAGQGELFLGDNCVLGTSFDANVTDEKDFTPLMWASGFGQLETVQKLLKLGAVVTSTGKSGENALILASSSGHAAIVRELINYEAEVDCVDQDGNTALMHAVYNNHAACVQELLNAGADFTITNEAVETAFDIAIKKRSKHAQAVLEKHMLNLMQVGSSTPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W296</accession>
    <name>A0AAV6W296_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_012826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W296"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8201767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="8263" checksum="E6B16C271A2C8C5A" modified="2024-11-27" version="1">MAKSKNHTAHNQNRKDHRNGIKRPSRFTKMSMRGMDAKFLKNLKYAKKHNKKLMPKVKPQTPKAAPKPLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W3N3</accession>
    <name>A0AAV6W3N3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W3N3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="9831" checksum="7AC5EA9C4EAAF727" modified="2024-11-27" version="1">MASPSLVETSFIGSSFVSRNVLLNGYLFLSPCYIVSHISEPLGRKIANLTGYLTDKTNAPTYGKEKVKNRRCTNNEMKLCLDSWIPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W418</accession>
    <name>A0AAV6W418_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W418"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9816" checksum="B0C639612840812B" modified="2024-11-27" version="1">MFVNPVNQSNTRPPPYSRRACNIVELDVTGLNISMVNIQQDDSSFVNAFLQNYCPNYAIEICFRFLVAVQDTDVLYSAGKARHQKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCR6</accession>
    <name>A0AAV6TCR6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007196">
        <property type="protein sequence ID" value="KAG8155689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCR6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8008" checksum="508B2A2A403B3898" modified="2024-11-27" version="1">MGLATTLGNSPVKGMAAESSQARSLRNANSPRPCERGIGAGFSPPVSPRPFTRESCGFFSSLIYMRKFSGLSRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCW1</accession>
    <name>A0AAV6TCW1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006836">
        <property type="protein sequence ID" value="KAG8155737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCW1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8155737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="37" mass="4082" checksum="CFB28B0D43858376" modified="2024-11-27" version="1" fragment="single">MHPSSRKTDVLHVPKSIPGSRIITFPAPDLMAPAQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TD50</accession>
    <name>A0AAV6TD50_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006583">
        <property type="protein sequence ID" value="KAG8155797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TD50"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="198" mass="22040" checksum="439335754BF32E35" modified="2024-11-27" version="1" fragment="single">TLGPEPVSCGKSSTPFSKNPKVKRIKGAPAFAVRIHTENSDQASFWPFCSTEFFLSSLSSPWEHLALPFDDVPPQAKRTHLNLVLVADRCATRMQRAGLEALILRIAFRLNRVTRAVHLGDLLRILVTDRPENYHLLGFQGPTERTGHRNRRDFSPSLRLSLESLLLPTKICTGGGSRRAHARHLNASPPRPSYSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJX3</accession>
    <name>A0AAV6TJX3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_027187</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010003269">
        <property type="protein sequence ID" value="KAG8172013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJX3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8172013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="118" mass="13522" checksum="6E81752ADF1A3FC9" modified="2024-11-27" version="1" fragment="single">YDTDFYILDKFPLKVRPFYTMPDPHNPKLSNSYDMFMRGEEIISGSQRIHDSELLLSKAKEHGIDVTKIQSYIDAFKYGAPPHAGGGIGLERVTMLYLGLNNIRKTSMFPRDPKRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TK93</accession>
    <name>A0AAV6TK93_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003545">
        <property type="protein sequence ID" value="KAG8171800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TK93"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10331" checksum="3DEE50A62D548B2C" modified="2024-11-27" version="1">MGFKGESIQDSEFVRDLGVLVSNDFKMSKQCVEANLSILLDVEVDELVESTRHPGIKLTLHDDSFSPDIHTDGQLIEPGMSYSIAISKVYKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TL43</accession>
    <name>A0AAV6TL43_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002652">
        <property type="protein sequence ID" value="KAG8172492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TL43"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="38088" checksum="25C9E1D6AA8744E8" modified="2024-11-27" version="1">MSPEYKLKRLLARNCNVSIPCELCPKGSQPILFKHLRTHVSTTHGIRCHRECQYCFGYQKWQKGDVKFNVKVHEHRLQCATSLLKCYNPKSQVVCEKSQPILSEEHMEEETSEETEYSKMIALGQKRMKQLQNLWCDMKKQFDSSYQRRAEASQEQEAQLRKQMNQLREQLNARQEQEAQLQKQMNGLRDQLNASQQWGAQLQDQLNTSQQWRVQLQDQLNTTQQWGAELQETLNLERDLNQTMKEDLKKEKRLKSIDAVITKVTNRKLEDSQRDVEMQELRNQLEAARKGWQTTQAELENRNRQLLKLEQRNILEKSAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLB8</accession>
    <name>A0AAV6TLB8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002652">
        <property type="protein sequence ID" value="KAG8172493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLB8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="416" mass="45921" checksum="F064BC775C1E8E26" modified="2024-11-27" version="1">MDTAGGSVHPEAALPPRLYVLELNKYSSPSASALPFESLARSLLERIIFDEDESGGPRNVLVLHETYVIRLFRRLCDAYRVSWNSILETTRQGCCVLDAHLHGMLSELWETRLSRSVSLDEQNCYERVMGRDHVRLSDLQKLAGTLARVAESKRVWTFFGVDGYLGDDPKRYVDHLRVRDEYVRTVGGWDVVRQIGEWRTEQKEKRKKSSGDETTTTRSGGGGKRKGKEDVEENDEDATTTTTSRGSGGGGGKRKGKEDVEENDEDATTTTTSRSGGGKRKGKENVDENDEVAIATTSRSGGGGKRKGKEDVDENDEVAIATTSRSGGGGKRKGKEFEEENDEAAVTTITKHSETLAKEEDDSNELNDETPPPSPPPPPPTHLVEDQIECGDCKPTRAKSRVQTHQVGYFTSHDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLV8</accession>
    <name>A0AAV6TLV8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002592">
        <property type="protein sequence ID" value="KAG8172559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLV8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="119" mass="13796" checksum="5340E4C63CEBBC6D" modified="2024-11-27" version="1">MQYIKTYKEQAKYRSGHRNNKKFKKVQKRPQGGRSILAQEILVAQVKGKSTESQGRDVAQKSLGGHQRVTPWTEAKHQTVAPRITREQGHTGRKHPRQSMRGLRRRPGKIDTRSRRSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMU9</accession>
    <name>A0AAV6TMU9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_023460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002048">
        <property type="protein sequence ID" value="KAG8173117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMU9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="5">
        <location>
            <begin position="28"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8173117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="297" mass="34309" checksum="192029DA4EC108B0" modified="2024-11-27" version="1">MSSEALPSLFSELVSSKCDGDRERTKSRFENQCKILDAKVFHLLKTKGQDVSDVLEYTSRAIDMVSNSKAKCRLLRHRLVSCKETLQCKRDDLRRLWLESLTHKHTHLLLAEIEGIRKTPDLVNEHLLAKRYELATRVLMSSIELLEGKLADIEALQELKLELHRLLDKLYAIFLEELIQELYMSTFHSVYQGDDDGSIKEVTYEKIFNYKPLKDGSRSINFNVSYVTVLLECMMMLGKITETMDILKEECEGELRKIIAKLSKLMHDIVQASTDTAILDLPESQGQRFCSTYWKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNP8</accession>
    <name>A0AAV6TNP8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_001425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001724">
        <property type="protein sequence ID" value="KAG8173470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNP8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005577">
        <property type="term" value="C:fibrinogen complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF5">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043753467" description="Fibrinogen C-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="6">
        <location>
            <begin position="57"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8173470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="145" mass="16907" checksum="51FF5CCA9B41F4A6" modified="2024-11-27" version="1">MLERRVDFIVLFMLLYVTANAQEKQDLDCGVKITTQSYLEIAQEMIKKVKDSNSNCPRQSSTTIDCETLLKSGNTKSKMYTVWPKSRILEEKPVEVYCDMETDGGGWTVIQRRGNFSRAKDYFFRNWEAYKKGFGNVEEDFWLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQG0</accession>
    <name>A0AAV6TQG0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001314">
        <property type="protein sequence ID" value="KAG8174124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQG0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9309" checksum="1A85005EF63B68BE" modified="2024-11-27" version="1">MVGVADLDKVVYKEQRFRRELTWAFGLEAGGTPKKKEDWTEDQKTCAPEDQKTCARPKTTEPRVVSASPLVGRPGGLIYKIAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQQ1</accession>
    <name>A0AAV6TQQ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_028358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001312">
        <property type="protein sequence ID" value="KAG8174128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQQ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043372445" description="C2H2-type domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="530"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8174128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="566" mass="61481" checksum="1D7C2489B25134BE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRT5</accession>
    <name>A0AAV6TRT5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001180">
        <property type="protein sequence ID" value="KAG8174610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRT5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="550" mass="63637" checksum="0C913BAE8458A662" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTA7</accession>
    <name>A0AAV6TTA7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001037">
        <property type="protein sequence ID" value="KAG8175287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTA7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="107" mass="11907" checksum="5185685F4D2A1519" modified="2024-11-27" version="1">MRKYQDIIYVWEYKVQAPEDFMHKPLKVEGAFLSPKLITLNSYKPNGVLIAVLGFFLICYGVFGRYLSSSLAFDVDTAQTLVGDAFMSAILSAIAASIGKLFITDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TU49</accession>
    <name>A0AAV6TU49_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001103">
        <property type="protein sequence ID" value="KAG8174961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TU49"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016184">
        <property type="entry name" value="Capsid/spike_ssDNA_virus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003433">
        <property type="entry name" value="Capsid_VP4_densovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02336">
        <property type="entry name" value="Denso_VP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88645">
        <property type="entry name" value="ssDNA viruses"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="251" mass="28151" checksum="2EEAF0191DF9CEF6" modified="2024-11-27" version="1">MRYSDFKTTGKEFHVNLAKELWGVRENASNFNTNIPKSSVGTPILLNRNLSVYTDDANPQHAGWPMLTEHLNFFDGDVAAGQYILDVSYIVGMGFLKTAPIAIMRPHPCFGDKTTESTVKVKVPMANKIMYSASGEYYVTKERQGGFTTVQVREAQTNEGSATTFDYYNTFDKSQITQPKSTLTCKLTLKLKQPVLFHLTFLHVILMLNCLTFNQVLFHSEPEVDDQATLNCGLKRHKVRTVIAGETLPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TV31</accession>
    <name>A0AAV6TV31_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_013408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000982">
        <property type="protein sequence ID" value="KAG8175589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TV31"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8175589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="168" mass="18861" checksum="C202119518DA9FF5" modified="2024-11-27" version="1" fragment="single">MNDPELYSRASPFQIRDASQVLGVYRKKMGGEVGDGTDTILDIGCGTGDVTSGILAPAIGRFEMLLGVDKSRDMVGYAQQHNSSDNIHYEVLDIAGDVEGFAADWGTFSRIFSFYCLHWVSDLKRALANVRRLLRPRGECMLVFVGQCPVFEMYARMAEMPKWKDYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVT8</accession>
    <name>A0AAV6TVT8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000918">
        <property type="protein sequence ID" value="KAG8176062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVT8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="200" mass="21888" checksum="8596EB4862875750" modified="2024-11-27" version="1">MSNPTPIMTLHSIPPKEQLAILTNPPAESIINRDAVIQLLSVANQYVATHNSYFLADDPTTSRSRQKYIEMLSIQDATIKFLGKLSSEEYIKAYRHSQVPSTNSNDGQTAGAELPCTVVPPGDGPRTPKPRPPQEGISAKELVVNPFHPDSSAPSIEDCNNFSLSPLDCTRLLYIVYILITAILFALCELESRLASTPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVZ4</accession>
    <name>A0AAV6TVZ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_013377</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000948">
        <property type="protein sequence ID" value="KAG8175826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVZ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="66"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8175826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="207" mass="23074" checksum="D29B65499615BED1" modified="2024-11-27" version="1">MEPNNVNASHNVTHVIVTKGPPVTSKVRRLAPDKLKIAKAEFDYMLEHGICRPSSSPWSSPLHLVKEKDGGWRPCGDYRALNAATLPDRYPIPHLHDFTHQLEGTTVYSTLDLHRAYHQIPMEPSDIEKTAICTPFGLFEFPLMTFGLRNAAQTFQRKSSSSSESSDVTDKTFGLGTTRGVGGLRSTRPRPFLLMHSESSKVFRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWR3</accession>
    <name>A0AAV6TWR3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_025546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000918">
        <property type="protein sequence ID" value="KAG8176088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWR3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOCS box" evidence="2">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="581" mass="65409" checksum="EDF2ECE1B72674EE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXR6</accession>
    <name>A0AAV6TXR6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000879">
        <property type="protein sequence ID" value="KAG8176458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXR6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="28" mass="3329" checksum="30EA8E1CFA8FF40B" modified="2024-11-27" version="1" fragment="single">KDAKLPVRILLFYEIISTTDIPTYLIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TY65</accession>
    <name>A0AAV6TY65_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_006957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000829">
        <property type="protein sequence ID" value="KAG8177015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TY65"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF69">
        <property type="entry name" value="PROTEIN BICAUDAL C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="172"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8177015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="260" mass="29402" checksum="DBD0CDEC0653CD26" modified="2024-11-27" version="1" fragment="single">NQALADLNLSPSSLSSDQSMESKASADPCNLFISEKNSESLAEDYYRKKVQAAKAMRRPIKSIESAQVPSSMWAGYGFSQSMPASVIKEAANQYYFNYNNDGGSRSSSEDSDSWENVVLKDCLDANVWSNNNSPPPPYSRHAQELSKLEGKSLLTFSHSNYFDFLRNMPVPFDYVTKDILPELLWQHGLHKYIDVFTKEEIDYQTFLVLTDHDLKTLGIAHHARMKIVCLIKELQDTRTNFKSKNFDAAPGAERKSESSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYM7</accession>
    <name>A0AAV6TYM7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_007488</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000845">
        <property type="protein sequence ID" value="KAG8176879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098858">
        <property type="term" value="C:actin-based cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048565">
        <property type="term" value="P:digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007424">
        <property type="term" value="P:open tracheal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007431">
        <property type="term" value="P:salivary gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035239">
        <property type="term" value="P:tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000104">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000140">
        <property type="entry name" value="Dachsous cadherin-related 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000226">
        <property type="entry name" value="Dachsous, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000353">
        <property type="entry name" value="Dachsous, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000032">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000058">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000061">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000081">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000134">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000279">
        <property type="entry name" value="Protocadherin-16, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
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    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
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        <location>
            <begin position="2310"/>
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            <begin position="2187"/>
            <end position="2288"/>
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            <begin position="2361"/>
            <end position="2419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
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            <begin position="2683"/>
            <end position="2729"/>
        </location>
    </feature>
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        <location>
            <begin position="2361"/>
            <end position="2374"/>
        </location>
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        <location>
            <begin position="2385"/>
            <end position="2400"/>
        </location>
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            <begin position="2683"/>
            <end position="2698"/>
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    </feature>
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        <location>
            <begin position="2710"/>
            <end position="2729"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004357"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8176879.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2729" mass="299461" checksum="D8BDC3437382AFE9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZT3</accession>
    <name>A0AAV6TZT3_9ARAC</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Oedothorax gibbosus</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8177017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1D8</accession>
    <name>A0AAV6U1D8_9ARAC</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="535" mass="61904" checksum="EC683EBACEF2F9B1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U356</accession>
    <name>A0AAV6U356_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
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            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
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            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000701">
        <property type="protein sequence ID" value="KAG8178352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U356"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13465" checksum="59C2A6EBB18539A8" modified="2024-11-27" version="1">MNVASCSSADQLSPPSLFLNEKPPCGPRYTVSIRRERELLLCYGLLYFSMVEMGDSGQGESSISQFFSCNICPDAFSLKSDYEKHMSASKEGHLFSHKASHGIFASESTLHISTTFSKTSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U537</accession>
    <name>A0AAV6U537_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_016629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000668">
        <property type="protein sequence ID" value="KAG8178764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U537"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="151"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="193"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="323"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8178764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="355" mass="39161" checksum="9EF2E27869DD22DE" modified="2024-11-27" version="1">MASDGSLKVDNPGETVDSLNKEVEILKTRLEEERKKLNDVALSKVAERLESIQNVNIKPRRILKGHQGKVLCSDWSLDKRHIVSSSQDGKMIIWDAFTTNKEHAITMPTTWVMACAYAPSGNMVACGGLDNKITVYPLSFEDDVSTKKKAVGTHTSYMSCCLFPNSDQQILTGSGDSTCALWDVECTHLIQSFHGHTGDVMALDLSPSETGNIFVSAGCDRQALVWDMRTGHCVQQFEGHESDINSVKFYPSGDAIATGSDDATCRLFDLRADREVSVYSKQSIIFGVNSVDFSVSGRLLFAGYNDYTVNVWDSLKCVRLSILYGHENRVTCLKVSPDGTALSTGSWDFTLRVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5Y6</accession>
    <name>A0AAV6U5Y6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000651">
        <property type="protein sequence ID" value="KAG8179079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5Y6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="460" mass="50786" checksum="41779C3795482CFE" modified="2024-11-27" version="1">MSHQTFRLHLPQKTSKLNVDSQLMFQAWYKVKGRVYRLKIDYTAAKQGMEAALRKSDFLKRVKKCKKYLVYRFLTASEVAEKKRMNKEKKKIAKPNPYSDSDCTLSPGSSGYSSGSDELGEMHGSPVPLLDWNDQEQVMKLENGSMEDVLLQGSVENLNGVLSFPDGTKVIVRDGYILSAIPLNAQLQPGEAFNMVTDVTFKGQSVEDINVVTDPTLTGQSGEDFNMVTDQTPTGQSGEDCNMVTDQTPIRNEGFVSKTEEIPFHENMKRASESSAVGDPGLSSALLLNQLQSIASAFANLSVDNSGSTHMDAGIPPSQNPVVDVNSLNPTLDASKYNDNLVDEVLDSFFNSEENSGEESQPTATVPLPANLDIISYKTNRYKVYECINRQDLSGMIVLICEPKLKEVCVTVGTEGEINKDEIVFDEATRQLISQNTVESVQLLSNDHLVVTLQCKEPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6I4</accession>
    <name>A0AAV6U6I4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Organic solute transporter subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_002288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000580">
        <property type="protein sequence ID" value="KAG8180162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6I4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8180162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33620" checksum="16D3B9E3964CDDB4" modified="2024-11-27" version="1">MEEAIAALGELSIGLVILGGIVTTGIYCIYIEELVYLYRNWPVKFFLLKLGCLSIFPIVGSCFFLNLLVPRATEYTTNTVVLCLPAPLVLFFWVVIGYASKERHLLERLEDKLIPLRGPPCCCVCWCCPKLPFSKQRFKVVKACIYQFFLTPVILFIIATVCSKYGVFKELKFVPDNAAPYLVGLNFASFFIGVYGLAIFTKTTSKLLHGFHIHGKFLSLQLQFILVRFHFFTFDTLGRLGFFPCHPPVSSLMTALYIRSALLLGEGFILSVVGRFFFLHAPPAHFVSVDPINHHQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8F2</accession>
    <name>A0AAV6U8F2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000573">
        <property type="protein sequence ID" value="KAG8180231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8F2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="59423" checksum="B12878CB7C7D3DEA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAE3</accession>
    <name>A0AAV6UAE3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000827092"/>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">W744_W776</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25368" checksum="260C5698947F7BDE" modified="2024-11-27" version="1">MFGVSEDGMMLQKAAVIFYYFHFAILMNLPTSTFAAFYVVVCYHLRCLLKRFARTYISDNDGIVDYKKLLRSFSSLHGTIQSIDNKLSIFVPLLTTNVSLTVAFVVSDMLRHSNFYSSCFTCLDRVEKYINMVHAVILFVSVTISASLVHEAYDELRSEARRSLVLSDRVFTNEHLKFMICMEKGACLTVHKIVKIRRSFIVATFGCVVTYMLILDNMLVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UH30</accession>
    <name>A0AAV6UH30_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_003864</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000414">
        <property type="protein sequence ID" value="KAG8183514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UH30"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF73">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043327893" evidence="2">
        <location>
            <begin position="22"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="24"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="123"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8183514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="314" mass="35595" checksum="BCB2CC8CE1EF61EF" modified="2024-11-27" version="1">MQKYFLPSILTVVLTLATVQSAPPKFESDFDTKVFVEGSKAWTLCSATNDSPIKYKWFDKQRDEVTSSNDVYTIRDTAERSRLIFEKVTKSQEGIYTCTAENGLVTKLFRITVNSDAESENFTIEDVHVLNVTDSSVQFLVRASKSIGSYNVKYFEKMDTASVKTLQLPNGVDILIEDLIPSGLYTFQFQVLSSEGVLSNWSEPIEVVLLPYSPEMIIRGLSDNTLRVGWSKKWNDFSRETIDGYLLSYGYIQRESYDKFKAPSCMINIELQGACSYTSYTIADLFSKSYYEIQLKAHTKAGYGKPTVTKIYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHV3</accession>
    <name>A0AAV6UHV3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-soluble NSF attachment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_029323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000407">
        <property type="protein sequence ID" value="KAG8183741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHV3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000028">
        <property type="entry name" value="beta-soluble NSF attachment protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8183741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32492" checksum="8151138A1D368C0A" modified="2024-11-27" version="1">MADNEQRGMSLVAEAEKKLKSSQGFFSSIFGGSSKVEDACEMYHQAANAFKMAKKWTAAGSAYCEAADLHIKTGSRHDAASAFVDAGNCYKKTDPQEAISCLMKAVELYTDMGRFTIAAKHLISVAELYEVNDIEKAVSCYEQAADYYRGEESNSSANKCLLSVAKYCAQLEQYEKAIEIYEQIAASSLESSLLKYSAKEYFFRAGLCHLCVDLLNAQHALVKYEEQSPSFTDSRECKFLKELIEKLEDQDVDAFTDAVKNYDAISRLDQWYTTILLRIKKAVQDTPDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHY5</accession>
    <name>A0AAV6UHY5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000408">
        <property type="protein sequence ID" value="KAG8183722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHY5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="8232" checksum="2C97469F9FF70E07" modified="2024-11-27" version="1">MGCITSTTPKSPPEICTPQQVQINIIAASKTPSFASSISCEQKVSSQAAASPSVVDGLASVAMARSVSQTSQDADVEPAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIN2</accession>
    <name>A0AAV6UIN2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000380">
        <property type="protein sequence ID" value="KAG8184275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIN2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="207" mass="23854" checksum="6A897B1B1398D4E5" modified="2024-11-27" version="1">MYKLLITTNRKSRFTDSIKFSTFFPNKCMYVCVSRPYKTTPNNILIWTSSCLPRRIHCTQLMCPFASDNAKMMIDRPISLDIVILRLKTKLVCRKSNREAHCDGLYFPTVQFAIDQAVTVIPTGLLRIDNDQCWWPQESTNTDIELYSEDESQSLLTGPSRNKKKVPKSAQDNSIQYTSLTLDTNNLGNVQLEAECIEMPRKQWQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIU4</accession>
    <name>A0AAV6UIU4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_015562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000384">
        <property type="protein sequence ID" value="KAG8184197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIU4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8184197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="59356" checksum="D4326330154C573C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJA4</accession>
    <name>A0AAV6UJA4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000383">
        <property type="protein sequence ID" value="KAG8184210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1614"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1672"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1898"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2133"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2319"/>
            <end position="2384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2557"/>
            <end position="2608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1673"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1898"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2134"/>
            <end position="2161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2326"/>
            <end position="2349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2362"/>
            <end position="2376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2585"/>
            <end position="2601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2631" mass="291062" checksum="D63EE549B9764968" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKD2</accession>
    <name>A0AAV6UKD2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2HC/C3H-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_006713</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000388">
        <property type="protein sequence ID" value="KAG8184076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKD2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF66">
        <property type="entry name" value="ZINC FINGER PROTEIN 474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8184076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="353" mass="39768" checksum="6737C0FAC85F40B5" modified="2024-11-27" version="1">MPGPPVGSNFVPCHVCGRLYTRHSLPFHEPQCRERGRADSERKPSEHKKKPTVLDYTQWREPDKESRTSAEERDSISDCNRPPTRTLLNPTPNIVHPVIPPITKVHTKHAGATISRQPRTVSKLYDPRHFNNKAESIDIRSPQSSGCCRIRLPDSFASGSADFRTTKKSKMDRQPVRVWRHKPSTETARVVADQGAGNTHQGASEYARCNICGEQVELSRIKVHQSNCAKIGGLGSSKGASRRRPPTVVCYICGRQFGTRSVGLHEPHCLKKWHLENDRLPKNLKRKEPKKPEVILRGDGTFDTSAMSEAAWQIHLEQLVPCSNCGRTFLPDRLDVHLRGCSTPNNRPVKVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKE9</accession>
    <name>A0AAV6UKE9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000382">
        <property type="protein sequence ID" value="KAG8184224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKE9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="210" mass="23421" checksum="F442CA820CD8D29A" modified="2024-11-27" version="1">MILFLCGGSSLPISATPPPLCERKIKRLRGKVANEKGRGKRPERNELEEKKISVPKELRSRSSHPTLNSILEDVASDNNCPFQKMSPLYSKMSPISPVGFESRKGVVPKLPFSLPEGLLSHAIELVRTNVDCWPSPAKRPPRSKTLPVVIHHSIVPQLLRQTKDAKLRHGRMKRKYEILIGIVSARTFPTADTSAPAANTFLDDNHRPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UME5</accession>
    <name>A0AAV6UME5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipase A2</fullName>
            <ecNumber evidence="5">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphatidylcholine 2-acylhydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_013101</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phospholipase A2 family. Group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000364">
        <property type="protein sequence ID" value="KAG8184715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UME5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04704">
        <property type="entry name" value="PLA2_bee_venom_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.90.10:FF:000002">
        <property type="entry name" value="Phospholipase A2 group III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043955741" description="Phospholipase A2" evidence="16">
        <location>
            <begin position="49"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="17">
        <location>
            <begin position="229"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8184715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="355" mass="41134" checksum="354F1E8ECA538175" modified="2024-11-27" version="1">MHDDPGRFPRWCCYETENTRDKYASMTPHRLRLWVVLLLFALSSSTESHRTPWQRAVPYNGNNFGDFVCTRVLSDGEVERRIHKGRISAIETTVELVNPTPDNQVFSTSSSDQAEIQVLTLLQVTDGRHFIQLIYDSGWELRDCEYLKSAKSVDEFYDTFAAVDEVDCPRTGRSLNESAANNFRPFDVTDYPSLRRECRNLHKQIKEMSLHASNHHGGLQRLKRDLFLYPGTNWCGSGSNARKFNELGYNAAADRCCRDHDHCPYTIEGFTSKFNFFNFRFHTISHCDCDERFRACLKLSSTAAGNMVGKLFFNVVQTKCFLFQHTKKCAKRSWWGKCLKFEKEKSAFLREALKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMK2</accession>
    <name>A0AAV6UMK2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_018607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin Y subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000336">
        <property type="protein sequence ID" value="KAG8185384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMK2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20540">
        <property type="entry name" value="CYCLIN_CCNY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000011">
        <property type="entry name" value="Cyclin-Y isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012399">
        <property type="entry name" value="Cyclin_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028934">
        <property type="entry name" value="Cyclin_CG14939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="169"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8185384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="337" mass="38981" checksum="26FCDDE558D16C5C" modified="2024-11-27" version="1">MGNKVSCCSCNSPNFDRKLDGKLDFEGEYFEPNNDRSISNLQHISEREPEDFDADPSTHPTAGPIFMQRSKSDMRYFRERRRSQSNLLETRPLKKSSSCSTIYLDDSTVSQPNLKNTIKCVTLAIYYHIHNRTSNRTLDIFDETIHPLSKDKMHEDVEQKEPDHRSIYRFVRTLFNAAQLTAECAIITLVYLERLLTYTEIDIVPNTWKRIVLGAILLSSKVWDDQAVWNVDYCQILKDISVEDMNELERQFLEMLQFNINVPASVYAKYYFDLRSLADQNDLSFPSEPLSKERAQKLEAMSLALSGALVDLHQNGIRKWYSLDNLTILRKSAAILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMM9</accession>
    <name>A0AAV6UMM9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Suppressor of hairless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_003239</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000326">
        <property type="protein sequence ID" value="KAG8185700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMM9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990433">
        <property type="term" value="C:CSL-Notch-Mastermind transcription factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01176">
        <property type="entry name" value="IPT_RBP-Jkappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1450:FF:000001">
        <property type="entry name" value="Recombining binding protein suppressor of hairless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000003">
        <property type="entry name" value="recombining binding protein suppressor of hairless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000074">
        <property type="entry name" value="Recombining binding protein suppressor of hairless, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038007">
        <property type="entry name" value="RBP-Jkappa_IPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20144">
        <property type="entry name" value="TIG_SUH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="12">
        <location>
            <begin position="222"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="13">
        <location>
            <begin position="340"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="68"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8185700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="71660" checksum="76FBD1B31501D7B5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNY1</accession>
    <name>A0AAV6UNY1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000324">
        <property type="protein sequence ID" value="KAG8185807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNY1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="177" mass="22751" checksum="3878AA8299872955" modified="2024-11-27" version="1">MQEKVRELIDKLQEKLREKLLEEMREEMPEMTQEEMQDKIQDKMREMQDKRQDKMRDQMREKMQMQEKMQMQEKMQMQEKIRELIDKLREKLPEERREEMPEMTQEEMQDKMREMQDKMREKIREMQDKMQEKLREKLLEEMREEMREEIREKLQGELRDELREEMREEMRERLQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ01</accession>
    <name>A0AAV6UQ01_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cation-transporting ATPase</fullName>
            <ecNumber evidence="14">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_026785</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="14"/>
    <dbReference type="EMBL" id="JAFNEN010000304">
        <property type="protein sequence ID" value="KAG8186366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ01"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000023">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000026">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000045">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="950"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="975"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1015"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1056"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1088"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1129"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="46"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="188"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="288"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8186366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1206" mass="135931" checksum="782691599EF1002B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URR1</accession>
    <name>A0AAV6URR1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_004634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000307">
        <property type="protein sequence ID" value="KAG8186290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URR1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000001">
        <property type="entry name" value="Cystatin-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001713">
        <property type="entry name" value="Prot_inh_stefin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414:SF21">
        <property type="entry name" value="CYSTATIN 14A, TANDEM DUPLICATE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414">
        <property type="entry name" value="CYSTATIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00295">
        <property type="entry name" value="STEFINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="domain" description="Cystatin" evidence="6">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8186290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="11317" checksum="8A9A1DC647077AF5" modified="2024-11-27" version="1">MPKVGGTGDLREPDENVHQVTREVKDHVETKTGLQFEEFTPINYRSQLVNGTNYFIKVRHAPEQHLHLRVHRSFNGEVTLSAVQLDKKLEDELEYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URW6</accession>
    <name>A0AAV6URW6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000282">
        <property type="protein sequence ID" value="KAG8187000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URW6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="129" mass="14803" checksum="971B3A169ABED574" modified="2024-11-27" version="1">MPQPGHCGAWMKDRMINIWTKLWHLFAYTPCFFYLSSKPAEKKQFGSERFQVKGVILRWIRWNQNGTILLQGSRKTSLKSHVSETQTFIHPRSTREGVFPPSSPLAVDSGKGDGVGMLFLPEAFRNKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6US69</accession>
    <name>A0AAV6US69_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Mediator complex subunit 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED20</name>
        <name evidence="7" type="ORF">JTE90_020865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000297">
        <property type="protein sequence ID" value="KAG8186568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6US69"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013921">
        <property type="entry name" value="Mediator_Med20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465">
        <property type="entry name" value="UBIQUITIN SPECIFIC PROTEASE HOMOLOG 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8186568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="203" mass="22747" checksum="4D0C872EC2C99121" modified="2024-11-27" version="1">MGVVSIHLFPIPEGKSGQQAAEILQKRLETIGAVKTGTFCVECEMYYAATHINSNRIVNIIHDSEHPVTTFALLDTGTCLMADSQFDMLMLKMAGIYMPKKALKIESKGPRYEVHDFVIKLGSVSIGPSFRGILVEVEYTPCAIPLSCWDLMRELMQGFMGNSVQCPSQYLQGKMNEIYNPVDTVQQYMEHFNAFRRAPSGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USC2</accession>
    <name>A0AAV6USC2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000294">
        <property type="protein sequence ID" value="KAG8186654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USC2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12330" checksum="C52FCE4616E776A9" modified="2024-11-27" version="1">MDGKTFLKTVGQELLAANYDVKGHAGQKRSSSKKAQTNKSASATKKSAGTKTAAKKTSKPRKNSAKKPSKPKKKSAGTRKTSTSKARKNSTAKNKPKPKKPSKGKAGTDVQQQMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USV7</accession>
    <name>A0AAV6USV7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000284">
        <property type="protein sequence ID" value="KAG8186918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USV7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="116" mass="13646" checksum="0C4C5B7C04436B5A" modified="2024-11-27" version="1">MGLIHHYLRLFFRSTFAPIDQRRARRWTNVTSGVYFVSAWTAFGVAMYYCFNVKSEPDDSPYAGGKMYTAYDSIRKFGSEDKNTIFRIKGWNNFEVEEVTKKEAEEICKTNKRPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTD3</accession>
    <name>A0AAV6UTD3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000288">
        <property type="protein sequence ID" value="KAG8186821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTD3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="115" mass="12966" checksum="D698ACC58DB963B7" modified="2024-11-27" version="1">MPFPKWAVEPVFLVRKPLPPDKTDPVNYYPDKAEPGNFYPVVNAALVSCLRQLACVAKIADRIFDEIGCECRQIAERTERLKDKIHICNEIVSDFNARAVQDKHVSADVAIICLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVB6</accession>
    <name>A0AAV6UVB6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_009503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000272">
        <property type="protein sequence ID" value="KAG8187430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVB6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12336">
        <property type="entry name" value="RRM_RBM7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052285">
        <property type="entry name" value="NEXT_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13798">
        <property type="entry name" value="RNA BINDING MOTIF RBM PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13798:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8187430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="178" mass="20324" checksum="2E894A88C11CE5B1" modified="2024-11-27" version="1">MDEKEQTLYCGNLSEKVTEDLLYELFLQAGPLESVSIPKDKDGRQKNFGFVKFKHSVSVQYAVALMDGVALFGRILRLDVRSGSANAFNPFLEKLREYQRMSQRTHRSSQRDSGRQDSRRHDSRNDSRQDIGSRGGPSASYGGFSQQYMMPQSMQNLPQGYPMNYGGYPASNQWSQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVE6</accession>
    <name>A0AAV6UVE6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyl-CpG-binding domain protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_001192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000258">
        <property type="protein sequence ID" value="KAG8187818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVE6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032343">
        <property type="entry name" value="MBD2/MBD3_p55-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025884">
        <property type="entry name" value="MeCpG-bd_2/3_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14048">
        <property type="entry name" value="MBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16564">
        <property type="entry name" value="MBDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyl-CpG-binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-CpG binding protein 2/3 C-terminal" evidence="2">
        <location>
            <begin position="82"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8187818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19952" checksum="9F30DBC01798AC09" modified="2024-11-27" version="1">MLLTKRKRDQDEKPEKETVNRVNTSIVLPIRQTASIFKQSVTIFRNHESKPCPNVSHGQLEKPKQVFWEKRLQGIHACDKNGKVIETFELPSKIKAVGLQLGDETILRSIATALHINGHPITGQNKPKALLDKSPGVYINPSQPLVLGLHVTDEDIEEQEKRVLEARERLKEALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVN5</accession>
    <name>A0AAV6UVN5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000245">
        <property type="protein sequence ID" value="KAG8188249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVN5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="126" mass="14756" checksum="B98C7B4D6A6BE3BF" modified="2024-11-27" version="1">MITINRTKTGLKTKTTKLKNFVENFELDTSNDLKKLSLEEKLNNTSDVLNHIVELRTKVCELPEDVNIDNALEELENLEDTLSEIKMRRRRNQTIRIRSKEDDDHSILFRDLQRRTDKITSGDKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXJ6</accession>
    <name>A0AAV6UXJ6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_028657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000221">
        <property type="protein sequence ID" value="KAG8189117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXJ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000031">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8189117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="939" mass="107517" checksum="8ABF3E778912C698" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXW9</accession>
    <name>A0AAV6UXW9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000219">
        <property type="protein sequence ID" value="KAG8189252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXW9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="358" mass="41018" checksum="96710A8787479AE8" modified="2024-11-27" version="1">MTIKDLTDHWIGVPKSPYVHYTATVSSTTPTSPAPTSAPLATPKRSTKTKKRKKRKQNRKRRIDSDEMPQYRDVNNKDQYSDFDYDYDNYDNPSYNRQTSPRPYIMRSSASSPKTVYVNPSGSGSSPSVSAVYAGVPKVATYVVPSAKKYIVQRVNSHAIFVPPASDPSKMYSMASGSGMRRQDPFDYDDGASGGAHLGPQNGFPPRPVMNKITEAGGRQPCHGPECHQHHKGLVRFYWRRVVYPEGTRRGRRRPGRFRNRRRFRDGGRSPSDQKDVYAAEEDEDAEEDPEESEEENDEEEEEEDADESGESSNRRNRWRPKGYGHDLHEGSNYDDDDGRVYRDKRFAFKNQVRKRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2J5</accession>
    <name>A0AAV6V2J5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">ATP-binding cassette sub-family A member 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATP-binding cassette transporter 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">JTE90_014059</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis. May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes. In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP. May play a role in myelin formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000180">
        <property type="protein sequence ID" value="KAG8190582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051247">
        <property type="term" value="P:positive regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010556">
        <property type="term" value="P:regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000511">
        <property type="entry name" value="ATP-binding cassette, sub-family A (ABC1), member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000612">
        <property type="entry name" value="ATP-binding cassette, sub-family A (ABC1), member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="816"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="845"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="925"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1790"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1846"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1872"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1901"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1990"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="22">
        <location>
            <begin position="1028"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="22">
        <location>
            <begin position="2049"/>
            <end position="2285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1365"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1370"/>
            <end position="1399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG8190582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2412" mass="272994" checksum="5237CD7406501DB0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3W2</accession>
    <name>A0AAV6V3W2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000167">
        <property type="protein sequence ID" value="KAG8191092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3W2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="10693" checksum="84726798C3632603" modified="2024-11-27" version="1">MSSQIARSSIVSDYCSNRLNHLLAAGPSPTTHTRTQGRAHPYTTEPPFVHHAPVVRIIRCGFYFRKPSSPHGNLLRRRICRGTLSATWAASLAGMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4S9</accession>
    <name>A0AAV6V4S9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000171">
        <property type="protein sequence ID" value="KAG8190910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4S9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="177" mass="20565" checksum="11C8167F4FC1BD96" modified="2024-11-27" version="1">MIVIIVHYFQTIKTQLLQSQWKARSRSSFLITDSVHLPELFYEANYFNVHSVDVCAVIESLDDSIIGQDGNERQDVIIGHNRCRAQGKMHTKLSIWRRTLALFRNRRLRLSEMPFIQQLGGQSAWHLLRTTNFKPQDSVYFHETENICYHLMPLPGCIGFLLVQSVPIPNVPERISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V686</accession>
    <name>A0AAV6V686_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_003251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 2">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000162">
        <property type="protein sequence ID" value="KAG8191238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V686"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF905">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="130"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8191238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="565" mass="64415" checksum="60686D9981E3133C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7A5</accession>
    <name>A0AAV6V7A5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ran-binding protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_019595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RANBP9/10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000158">
        <property type="protein sequence ID" value="KAG8191531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7A5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000011">
        <property type="entry name" value="RAN binding protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="17"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="273"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8191531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="66754" checksum="B64AFEEC5B850643" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8D9</accession>
    <name>A0AAV6V8D9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_028110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000132">
        <property type="protein sequence ID" value="KAG8192990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000177">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="4"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1849"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1902"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="334"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="840"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="904"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1277"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1426"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1505"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1670"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1814"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1916"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1931"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="83"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8192990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1966" mass="225367" checksum="8332C08D547DD97E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDH6</accession>
    <name>A0AAV6VDH6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Chordin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_011504</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the chordin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000113">
        <property type="protein sequence ID" value="KAG8193955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDH6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016353">
        <property type="entry name" value="Chordin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052278">
        <property type="entry name" value="Chordin-like_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010895">
        <property type="entry name" value="CHRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46526">
        <property type="entry name" value="CHORDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46526:SF1">
        <property type="entry name" value="CHORDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002496">
        <property type="entry name" value="Chordin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00754">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50933">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="CHRD" evidence="11">
        <location>
            <begin position="148"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="CHRD" evidence="11">
        <location>
            <begin position="541"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="10">
        <location>
            <begin position="703"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="10">
        <location>
            <begin position="882"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="945"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="962"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8193955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="985" mass="109437" checksum="CC4BCDBE8580D7F0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDK7</accession>
    <name>A0AAV6VDK7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000105">
        <property type="protein sequence ID" value="KAG8194301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDK7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8352" checksum="F759C2AFBFA43720" modified="2024-11-27" version="1">MSGYAPDDRIRELEQMFLGGPIIANGKSFSIETLLDVLLVLYDECCNSTLRREKTVSTFIENGKLKRSLKICIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDP4</accession>
    <name>A0AAV6VDP4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_003041</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000109">
        <property type="protein sequence ID" value="KAG8194098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDP4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03858">
        <property type="entry name" value="M14_CP_N-E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000020">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF84">
        <property type="entry name" value="CARBOXYPEPTIDASE M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043843286" description="Peptidase M14 domain-containing protein" evidence="11">
        <location>
            <begin position="22"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="27"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="404"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8194098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="478" mass="54079" checksum="5312BC7D0FD39F2F" modified="2024-11-27" version="1">MSSAIATLFLSSLVLFSVVSALEVDFTYHRFPQMTNVLRQLNREYPEMTKLYSVGKSVQGRDLWVMLVTRDPDDEPLLKPNIKYIANMHGNEPVGRELMLHLLQHLLSNYGSDSYVTWLLDNTRIHIMPSMNPDGFEVAQEGECSGVQGRGNANNVDLNRNFPDYFAGPSKAPTQPETRAVMDWIKKTQFVLSGNFHGGALVASYPFDNIPANSPRNFRIVGSPSQTPDDDVFRHLAEVYSFNHKNMYVGVTCRDGSPPFPNGTTNGAAWYSLIGGMQDYNYVWASCMEITLEISCCKYPRHHLLPQFWTDNKNAILQYLGEVHRGVWGQVKDSNNNPISNATVKVMGRDFGFKTTDRGEYWRVLRPGTYTLQVEARGYDSLEIPVKVTKGVTIQNITLNPQTGTYHEPHNEQPAYQGYPSISPSQQENSGTSLRGLWPTYRNLLKQPKEAVIFPRLSYGVNYRQQPSHPLLNYNIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDY4</accession>
    <name>A0AAV6VDY4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_008173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000095">
        <property type="protein sequence ID" value="KAG8195000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10529">
        <property type="entry name" value="SET_SETD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000150">
        <property type="entry name" value="Inactive histone-lysine N-methyltransferase 2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="352"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="673"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="719"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="794"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="892"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="980"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1121"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1215"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1621"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1575"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="576"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="682"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="719"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1251"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1322"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1358"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1391"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1427"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1456"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1474"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1627"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1658"/>
            <end position="1667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8195000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1789" mass="199738" checksum="EE2B399CB8FC8424" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF03</accession>
    <name>A0AAV6VF03_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat-containing protein 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_013248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the Mettl1-dependent formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the Mettl1-wuho methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required for binding of nanos mRNA and repression of translation by the mei-P26-bgcn-bam-sxl complex. May cooperate with mei-P26 and nanos to derepress the BMP signaling pathway. May cooperate with mei-P26 to suppress expression of a subset of microRNAs. May cooperate with mei-P26 to regulate bam expression levels in germline cells during gametogenesis. Required to promote mitosis to meiosis transition during gametogenesis. May regulate germline cell division in part by regulating ribosome biogenesis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a heterodimer with the catalytic subunit Mettl1. Interacts with mei-P26 and weakly interacts with bgcn; required for the function or formation of the mei-P26-bgcn-bam-sxl complex. Interacts with nanos; may be involved in mei-P26-dependent derepression of the BMP signaling pathway. Interacts with Myc; the interaction may be mediated by mei-P26 and may be involved in the regulation of ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VF03"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8194495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="414" mass="46503" checksum="0C99A4B13A6D1412" modified="2024-11-27" version="1">MAFYTNAKNVGASLFLKNDEIFVFSEDSATNPNTVDPIKLKCKLSVIVQTSDDAGKKSKKQTKETETPTNFITSAIVSNCSTYIAAGDANNSLHLWKKENKEWKITSVRSVVRKCQKIIFTNSASDIIVADRGGDVFTFSVSKSNDPASFLLGHISLILDMSISSDDKYLATCDRDGKIRVSHYPNSYNILSYCLGHQEFVSSLQFLPLYDGEVLVSSSGDGTMKMWNFTDGSSKESVSFHENDSLCRDCNVKVEGQSEILSDNLALSEKQVMFSVRSVKYNQKYRLVIVLFHLQCCVAVYRLCDGELKSFVFKQLIPLTTPPLDAMFTDNGNLYVLTKKKGNALVYFKYHETSEAISKAEDSELSSLKDVQEFYKDHEQIPFQDDFVSLFKRVYDVPDDDECGESKGKKNKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF69</accession>
    <name>A0AAV6VF69_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_001368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000089">
        <property type="protein sequence ID" value="KAG8195349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VF69"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043854478" evidence="2">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8195349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="148" mass="16492" checksum="288A67E79A88EF63" modified="2024-11-27" version="1">MLSTKHQSILLACLVISCSLVLPVVSFGGNHHDHHGLEVLLAAGLLAKLLKQHHKHEVHHVHIPVPVHHHEEHHGHHEEHHGHHGHHGSGSARVPVMRPPVPHHYPVVPMQHLYGGVPMMGAHSMMARRVMYVPPQARDAPFPCPLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFA6</accession>
    <name>A0AAV6VFA6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000090">
        <property type="protein sequence ID" value="KAG8195325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFA6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="66" mass="7202" checksum="17B1CBB43C8853D7" modified="2024-11-27" version="1">MKRRGSSAAPYRAMSSSMSQKTVFQNVPWKRPTVPWIETQEDSSKRGRGGVAGVVDPHICPGVATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFI5</accession>
    <name>A0AAV6VFI5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein CLP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_011002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000103">
        <property type="protein sequence ID" value="KAG8194388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFI5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="5">
        <location>
            <begin position="116"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="3">
        <location>
            <begin position="311"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8194388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47922" checksum="791325F852040028" modified="2024-11-27" version="1">MAFEPTTRFVLEYESELRVHVGEKTRAVKIELENGKAEICGTQMLLNKVYELPPNVSIGVFSWQGCTLKLTGNPKYVKTEKETLMILNTIMHACLQEQRNIAQETNTKGPVTLVVGPTDVGKTTLCQTLLNYAARMEFRPIFVDLDVGQSNISIPGSVGILCVDKPADIVEGFEVTAAKVYHFGYKSPSFNLPLYFLLLKHLANVIKNGLSVARPIVRSSGVIINTCGWVRGHGYDIITHAAMAFEVDRIVVIGEERLQEQLTRDVPASVKVEYMPRLSGAVERSKSSRIRSREARILNYFYGSTRQFSNYTITVPFSDVRIYTIPQEHVSDDAKIDSLSIDIESVKMKPVSWSTGLKDQVLALMKVPKSVETVPDDLVTTEVLGYVMILDVNMKAQVIQIKSPQPNSLPSKYFLMGDRKFNEHIIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFL2</accession>
    <name>A0AAV6VFL2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Guanine nucleotide exchange factor DBS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_019503</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MCF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000085">
        <property type="protein sequence ID" value="KAG8195514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFL2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11856">
        <property type="entry name" value="SH3_p47phox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000078">
        <property type="entry name" value="Guanine nucleotide exchange factor DBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056466">
        <property type="entry name" value="Spectrin_DBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF211">
        <property type="entry name" value="LD43457P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23289">
        <property type="entry name" value="Spectrin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="12">
        <location>
            <begin position="76"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="592"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="792"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="1019"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="932"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="938"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="950"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8195514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1118" mass="127407" checksum="AF778531B8E62315" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFY2</accession>
    <name>A0AAV6VFY2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_002968</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Large subunit of the RFC complex, an heteropentameric complex consisting of RFC1 and four small subunits RFC2, RFC3, RFC4 and RFC5; the RFC complex interacts with PCNA and the interaction involves RFC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000080">
        <property type="protein sequence ID" value="KAG8195705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFY2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17752">
        <property type="entry name" value="BRCT_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
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        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Replication factor C subunit 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RFC1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
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    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="14">
        <location>
            <begin position="248"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="318"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="917"/>
            <end position="998"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
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        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
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        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
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        <location>
            <begin position="940"/>
            <end position="958"/>
        </location>
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        <location>
            <begin position="986"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8195705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="998" mass="110848" checksum="9D6540414784613E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VG26</accession>
    <name>A0AAV6VG26_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_013894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000088">
        <property type="protein sequence ID" value="KAG8195442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VG26"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
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        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8195442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="45139" checksum="71B1A49A7C64AC69" modified="2024-11-27" version="1">MFSLLKSRNSFYFLFYVARFTGLPLPSSQPSQSKLESRNFNIFCLLLTILKTISFLFSCITIHHLVRATTLRLTFYSFNTCGTLTVFAIIAKKSSIRKTMKTLTQLRTELDFNCHVGSRQSIHLVIILASLVIIIFFAQIIFYFDKSHDDRWSVVKIYGLVLSNSTRRVYLDVYHCCVVFTYTNSTITVCLMSLVSYNVSNVLGDIIKSYRKRLMAILRHPNPTVDDIHVSVTLFRRIVCCTRDIEHALSLCLLLLYGASVTWIFNSFNVVIVRDKVYHNKLAYAFVAITTAMALIVFFTVTQGASRLISEDKKLKCLTVRLAERPFTASYASSFCVCNLSTLHCIKLLMRSIRGNRIYLTAGNMFILQRSLVLTMFGLISSYGVLLHQFGDYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGB5</accession>
    <name>A0AAV6VGB5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000100">
        <property type="protein sequence ID" value="KAG8194711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGB5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037660">
        <property type="entry name" value="CCDC51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28624">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28624:SF1">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28721" checksum="CDBE73EC65F6C9B5" modified="2024-11-27" version="1">MHEAVLETQKNIQSVQEKRRKVQEDLFVAQKKLQESRNLLHKTAMDDSMYITVVTQVHEMLKEQGHLQDTFSSYDQQERELQSNLAISINNSQDHERTYREKTKYLSLVTGLVGGLLGFLGSSINNWRLRREIKSFANNISGQVVALQENVKKLKGTDPKYQETLSQMRSQQELFDKSIVALNTLITSPVSRDIEVFNEPYLQLKFDEMSNRLEEDWDSKLRYHTSINIAVISSLLLVGAVVLYVIDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGW4</accession>
    <name>A0AAV6VGW4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoenolpyruvate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_021417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000096">
        <property type="protein sequence ID" value="KAG8194956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051549">
        <property type="entry name" value="PEP_Utilizing_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43615">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43615:SF1">
        <property type="entry name" value="PPDK_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="3">
        <location>
            <begin position="426"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme mobile" evidence="2">
        <location>
            <begin position="1237"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8194956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1318" mass="148826" checksum="907D80E8393A7BF1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHK9</accession>
    <name>A0AAV6VHK9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHK9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="271" mass="30576" checksum="741937D9E8E4BE03" modified="2024-11-27" version="1">MRGWRKRRLMDDPGRTRRLVWETRGEGGSSRESPERFLSIRFDFGLPLLFINGHSLKTHSRVHLGILFCSVELSHLRQALNFVKSTRLSVDSVAKTLFRVFGSREANSSVSALFVAECVFWALPALFRNQRLARVGKHTGTIEILEVQIEAPDWHVSAVLPSGALKKVREGKEEALTGGPTGCATGLGAWPGACISKRGVATARGRHSSKFFEEVSLGRLVTHPFLLARREESRHLAKLKREEKRRRQQRCGVVVFSCDSYPTSHHHHYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJ75</accession>
    <name>A0AAV6VJ75_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000081">
        <property type="protein sequence ID" value="KAG8195671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJ75"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="11506" checksum="AF0FFDD5A0624D01" modified="2024-11-27" version="1">MVRLCSLTIYGHENAEVVRVEAFGIIHEHAEETLESRGPWQKRLLAASSVVWMVRTRRQTDELLRACFCCRMLGIKCIRQMRKDHRMKMMHTGRELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJS9</accession>
    <name>A0AAV6VJS9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="3 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_004324</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3 11"/>
    <dbReference type="EMBL" id="JAFNEN010000059">
        <property type="protein sequence ID" value="KAG8197055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJS9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 10 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="12">
        <location>
            <begin position="5"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="10">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8197055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="230" mass="25398" checksum="06EF87927261848B" modified="2024-11-27" version="1">MSKINWLPLESNPDVMNKFLEHLGVPPSWGISDIISLDDELLSMVPTPVLAVLLLFPISEKYNDYCNEQEAIAKSGDQNTDPSLYYMYQTIRNACGTVALIHAVANSREHFKLDPTTVAGKFIEDTKSMSPQEKAEFLEGSNEISAAHEASAEEGQTEAPSLDDKCNLHFIALVQVNGKLYELDGRKTAPVAHGDTNPDSFLKDAAKVCKEYMQRDPENLNFTALSFGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VK90</accession>
    <name>A0AAV6VK90_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SSUH2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000058">
        <property type="protein sequence ID" value="KAG8197235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VK90"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052789">
        <property type="entry name" value="SSUH2_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="41413" checksum="6F56B5F7E49A8443" modified="2024-11-27" version="1">MNDSKPPPYEASFAASAVTSSAPSINKGFEPDEGISNPPTAPPYDATPVERPPFISFGTLTDQELRDACFEYIDDKCCYGSRFIKDMTLIDIYASYTFHYKLETFCERRESKWTSVAYYGQRIDGPENGPVPSVWDMRVREPTKFKNDRTYEELPHTATVKRCTTCHGDGRVRCSNYYGDGWNQCYLCGGRGTDREEERCSNCNGRGKKKCSRCDGRGRVDCSPCNGHGKLKYYRELIVTWSNYVDDFVSDTMKLPKELIKEVNGKRVFREQNNQVFPFYHIPDAKVNEASSRFIQKSKTSHNQEQILEQRQTVWAVPLTRAKYLWKRWQDEFYVFGLEKKVYFDHYPQQCCYCTCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKX5</accession>
    <name>A0AAV6VKX5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CABIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_013451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000056">
        <property type="protein sequence ID" value="KAG8197324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKX5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025946">
        <property type="entry name" value="CABIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052281">
        <property type="entry name" value="GAREM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454">
        <property type="entry name" value="GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454:SF11">
        <property type="entry name" value="SERRANO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12736">
        <property type="entry name" value="CABIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CABIT" evidence="2">
        <location>
            <begin position="10"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8197324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="361" mass="41363" checksum="EA3D895D157259DC" modified="2024-11-27" version="1">MPDGRTATCFQSIGEVSRAGLPMFLVQDSVLGLMVESTGLNRKLVPHGEVLKVVQIYEDANREKICQQLKRDIHPDIMMYLKCLTRQGEVVFLPYSTKGRFYYISTPEYHTLNHVYLISNLLRVTKLPVVVRIVTGPKPQIALPISNIVQLNEVQYETVILGCTMVGNKPVLLEINANSQFSFVTAKDKSSASKTSAFKRMHQVCVMEGERWRQQIRVAHHVISRANSLSSISRFSYAPSSCTSISKAKRIDLKPSLPPTALVQHVRYSYYDRFFSKRFWSFRKSKRAEYPNVHTGSFRLPVEMVKNYVKRKGSKGSESKESSQRRRLRKFRMEYPRIFHSSDDGYSTSCADVESIYNSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMG8</accession>
    <name>A0AAV6VMG8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMG8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="133" mass="14798" checksum="52F84AB36BB09823" modified="2024-11-27" version="1">MRLVIIPSIHLTPIQSLTTPVHPHRNTSLRVYSLSENRPVNTTLAVQHVPVTVLPRQVTPQLGVQLRAHVGHVFQLGDAAPVVRGPDGEQLRVAVRAEGELRGEQYEPEQEVLVAAARPRVREHRVEGHLFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMQ9</accession>
    <name>A0AAV6VMQ9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="13">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="13">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="13">PHB:PPT</shortName>
            <shortName evidence="13">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_013131</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-decaprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60721"/>
            <dbReference type="ChEBI" id="CHEBI:84503"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:44565"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>all-trans-nonaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-nonaprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17709"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58391"/>
            <dbReference type="ChEBI" id="CHEBI:84502"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17710"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:44505"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
            <orientation evidence="13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="13"/>
    <dbReference type="EMBL" id="JAFNEN010000061">
        <property type="protein sequence ID" value="KAG8196981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMQ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8196981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="406" mass="44996" checksum="440357267F042D5C" modified="2024-11-27" version="1">MWKNLLHAQKSVLGKCVYSKTSKTIYRTTYLCFNPLKGNFVKNNNKVTACFYATKAGSSDIKETKDNDSKTLEKLSLAETLVNKSPSGLQPFLKLMRIDKPTGTWLLLWPCYWSISLASAPGCLPDPTLIALFGTGAFLMRGAGCTINDLWDKDIDSKVARTKDRPLARGDLTVLDAWMFLGGQLSLALLILLQLNWHSIVLGASSLFLVTTYPLVKRFSYWPQLMLGLTFNWGALLGWSAMHGSCDWSVVLPLYMACVSWTMIYDTIYAHQDKVDDVLIKIKSTALKFKEDTKYYLAGFSTSMIALLVLAGYNCNQTWPFYASVGVTGLMLTKQIASLNINDPQSCWAAFKANRKIGLVLFLGIVGGNLAKEIKDSNVKKSNLLMNEPFLSSSTSSDLPLGKAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VN17</accession>
    <name>A0AAV6VN17_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_001568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VN17"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000060">
        <property type="entry name" value="Protein phosphatase 2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8197638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="621" mass="70087" checksum="1096E87A8F7436A5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VN95</accession>
    <name>A0AAV6VN95_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_007528</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VN95"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8197282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="353" mass="39518" checksum="59EAF63F3282E241" modified="2024-11-27" version="1">MRVECSAIIQQLVRVLPESPNWLLARGRFEETIRLVRTIASTNGRELTPDFIVATKRKFILERSLREHKNEPKTQKEATKELFRTKGLRKRTIVLMFSWFTSTASFLGLNYLCIELEGDVHYNVLWSAVAEVMGWAVAAVLLKCTAPRRCTNCVICAVGGVLCISLAIGRRGKSSSASLTLYVSTKLTVSISYFVFPLWSAEILPPGPRETALVLSEILNLACPVFLPLLIYQGRTHPLLPMTLLGLLHVIGGLASLLLPETRLISFLDQPVVAPPTQHWTEHNCAHCHASPNCTPRKGIRNTNPIPESPIFSLLRCQEHQMYSGRESAMSDLSNSRHLERHLSMDELKVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNA2</accession>
    <name>A0AAV6VNA2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_007251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000054">
        <property type="protein sequence ID" value="KAG8197513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNA2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018586">
        <property type="entry name" value="Brinker_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09607">
        <property type="entry name" value="BrkDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="TrpR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brinker DNA-binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="67"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8197513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17620" checksum="00EFBD27C66AD68A" modified="2024-11-27" version="1">MDRRKRFSYEASFKLKVVLRAEEANNMVAAREFGVNEKSFREWRKLKGVLKKSKKTAKAARGKAAQFPDLDKAVLTWVLESRQKGHIVTRTAIRLKALHLAKTVVKNHPGGEFRGFGWLVLTFHGAVWTFSSATDQDCPEVAQTTGREDSSLSKGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPC9</accession>
    <name>A0AAV6VPC9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000047">
        <property type="protein sequence ID" value="KAG8197960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPC9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8010" checksum="1B651EDFD6D93B6A" modified="2024-11-27" version="1">MSGVEENKSANAATNDPPGESPPDNHQTLKNMTNRHQKIHQILMGLANLHQTIHQTLMVASLHRKSTGQSTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQM6</accession>
    <name>A0AAV6VQM6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_017388</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000039">
        <property type="protein sequence ID" value="KAG8198523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQM6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8198523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="120" mass="13813" checksum="C8D4BEC56B0973CE" modified="2024-11-27" version="1">MDYPNVYPEFAFHKQQKKIVNQHLPPKRYNETRKNPFRKYCIRLCKESLITGFPALASDRIGPCRRAMKALVLVVCVCGFLYQTSEFLGLYLEYPTTLNMLVEHPDSVSVPAIGLCNSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQZ4</accession>
    <name>A0AAV6VQZ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YLPM1-like spectrin repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_006926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000043">
        <property type="protein sequence ID" value="KAG8198181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQZ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058903">
        <property type="entry name" value="Spectrin_YLPM1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26583">
        <property type="entry name" value="Spectrin_YLPM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YLPM1-like spectrin repeat" evidence="2">
        <location>
            <begin position="65"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="YLPM1-like spectrin repeat" evidence="2">
        <location>
            <begin position="147"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8198181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="661" mass="74164" checksum="5AC0191159C4F94D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRN8</accession>
    <name>A0AAV6VRN8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ECT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_009369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRN8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000431">
        <property type="term" value="P:regulation of cytokinesis, actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01229">
        <property type="entry name" value="PH_Ect2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026817">
        <property type="entry name" value="Ect2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049395">
        <property type="entry name" value="ECT2_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16777">
        <property type="entry name" value="PROTEIN ECT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16777:SF2">
        <property type="entry name" value="PROTEIN ECT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21242">
        <property type="entry name" value="ECT2_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="98"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="206"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="302"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="482"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8199527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="955" mass="107749" checksum="4726E721D26DEDF0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSM0</accession>
    <name>A0AAV6VSM0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_016225</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000031">
        <property type="protein sequence ID" value="KAG8199088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSM0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000002">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000023">
        <property type="entry name" value="Signal recognition particle 54 kDa protein putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11 15" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="16">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8199088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="503" mass="55538" checksum="FD1741B5F9FC372D" modified="2024-11-27" version="1">MVLADLGRKITNALRSLNNATIINKEVLDSMLKEICTALLEADVNIKLVKQLRENVRSVIDFDEMAAGLNKRRMIQSAVFKELIKLVDPGVKAWQPSKGKPNVIMFVGLQGSGKTTTCSKLAYYYLKKGWKTCLVCADTFRAGAFDQLKQNATKARIPFYGSYTEVDPVVIAQEGVDKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVSNATSPDNIIFVMDASIGQACESQARAFKDKVDVGAVIVTKLDGHAKGGGALSAVAGTQSPIIFIGTGEHIDDFEPFKVKPFVSKLLGMGDIEGLIDKVNELKLDDNEELIEKLKHGEFTLRDMYEQFQNIMKMGPFSQIMGMIPGFSSDFMTKGNEQESMSRLKKLMTIMDSMNDRELDHREGAKLFTRQAGRITRVARGAGVATRDVQELLSQYTKFAAMVKKMGGIKGLFKGGDIAKNVNSVQINKLNQQMAKMMDPRVLQQMGGISGLQNMMRQLQGAAGNNIGGNTRSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT33</accession>
    <name>A0AAV6VT33_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_003665</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFB10 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000029">
        <property type="protein sequence ID" value="KAG8199238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT33"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019377">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10249">
        <property type="entry name" value="NDUFB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8199238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="162" mass="19507" checksum="FE18C535B056F033" modified="2024-11-27" version="1">MALEPKKERNVVDKIQNKIFGWIDGPVTWFRESVVLPNQKPPVYYHRKYPRVPTIDECYEEDGPCMFEANEQFKRDMQVEGKIVDILNRRKLDCYRHEGHERHERCKEIFEQFEEANKNYFIKYGDLGAYAHAKFAYMKQKHRMVYERQKAAGTWNPDNITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VW91</accession>
    <name>A0AAV6VW91_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">sn-1-specific diacylglycerol lipase ABHD11</fullName>
            <ecNumber evidence="3">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha/beta hydrolase domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_000831</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48596"/>
            <dbReference type="ChEBI" id="CHEBI:11152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:90605"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77107"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:77129"/>
            <dbReference type="ChEBI" id="CHEBI:186738"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75468"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38503"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:77272"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VW91"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000039">
        <property type="entry name" value="Esterase ybfF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="13">
        <location>
            <begin position="39"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8199736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="288" mass="31882" checksum="6F589C695BA43CCF" modified="2024-11-27" version="1">MVKNRDSRCLSSSVSNSSSSTVTLSCDVFAPEKTVSPVPVIILHGLLGSKKNWRGLGKAISEKNQRKVYALDARNHGDCPHSDKFDYPLMAEDVKNFMTSQSIPEAVVIGHSMGGRTAMLLALTNEPLVNKLIVVDVSPSKMPSQLQFIPGYMREMKKAIAAVSATGLSQGRRAIDKHLSQTIPEASIRQFLLTNLTEKNKMLSWKPNIDVLLEKFDASINMFPAVEGHYSGDTLFICGGDSPYVKTEDHPFIQTLFPKSEFIKIPNAGHWVHSEKPSEFLQAVYDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWN5</accession>
    <name>A0AAV6VWN5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_000573</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18018">
        <property type="entry name" value="DEXHc_RecQ4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22289">
        <property type="entry name" value="RecQL4_SLD2_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent DNA helicase Q4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RecQ like helicase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF108">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="636"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="844"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8200495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1349" mass="152209" checksum="812A099B65ACB65D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYJ7</accession>
    <name>A0AAV6VYJ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rrn7/TAF1B C-terminal cyclin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_011225</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000004">
        <property type="protein sequence ID" value="KAG8201550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYJ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005668">
        <property type="term" value="C:RNA polymerase transcription factor SL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048538">
        <property type="entry name" value="Rrn7_cyclin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20645">
        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rrn7/TAF1B C-terminal cyclin" evidence="11">
        <location>
            <begin position="300"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8201550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="665" mass="77764" checksum="E39A7DDC7EA6C66A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZV3</accession>
    <name>A0AAV6VZV3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytosolic purine 5'-nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_016866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000006">
        <property type="protein sequence ID" value="KAG8201392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZV3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046037">
        <property type="term" value="P:GMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07522">
        <property type="entry name" value="HAD_cN-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000021">
        <property type="entry name" value="NT5C2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016695">
        <property type="entry name" value="Pur_nucleotidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02244">
        <property type="entry name" value="HAD-IG-Ncltidse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF15">
        <property type="entry name" value="CYTOSOLIC PURINE 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017434">
        <property type="entry name" value="Purine_5'-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="535"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8201392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="66646" checksum="954FBD9004CF9E52" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZV9</accession>
    <name>A0AAV6VZV9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZV9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9638" checksum="C19218BE2DDB50CC" modified="2024-11-27" version="1">MHPFFKKRRRIEEEATVESDPAVVNSEASTSFVLSTPEIPTEPENCHGPMSGPMKCGMKRESFTLGLTPVMEKLDVDIVPALKILAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W0B7</accession>
    <name>A0AAV6W0B7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_010516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W0B7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38332">
        <property type="entry name" value="PROTEIN CBG11604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38332:SF2">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8202159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25114" checksum="B3D0C2F616886945" modified="2024-11-27" version="1">MVMRGIDKEHLEKRPTESYPSCIGKPTGRHRGVCELGTDCRPWTLYFNNGNDFVYLKKGGHAVSDLNFLSRRDKTTMIHIFALTTISILMNRINEGNAISCYTCNSRNGTDQNCHDPFHPAMSTYTEACKVPKEGHIGQFPANFCIKVIGKTIQTEVEHVIRACVLENMDNQCGVFRFEEDTLQGCILTCDYDGCNGDSQLQGGALLLIASILLKLLVRTFNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W326</accession>
    <name>A0AAV6W326_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W326"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="136" mass="14991" checksum="E9E6E36199C3F898" modified="2024-11-27" version="1">MVKGITFDPAVGSSFNLLSPVPILVIGNIGGQLTSGARATKRWFRSQITIEEKRVNYFQGVAPEAKQITVRMSKSFSRDSVSDLIAVRQSVKTMEEITKASRSISKQKEMNRPPLIKTDREITSPGLAISAKEMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TF70</accession>
    <name>A0AAV6TF70_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005557">
        <property type="protein sequence ID" value="KAG8170387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TF70"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="10079" checksum="9C80A8AF5F1B0663" modified="2024-11-27" version="1">MCASQWVLNKPGGEMKVQAGGGRPHSGSPFPRGRGAPEPRRVPLVEVAEFERTRWDPKDGELCPDRTRPEETLVEVRSGSDVQIDRQIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFV5</accession>
    <name>A0AAV6TFV5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_014854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005011">
        <property type="protein sequence ID" value="KAG8170700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFV5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043406277" description="CUB domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8170700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28757" checksum="A8D0BAB4449F67C5" modified="2024-11-27" version="1">MAGTPLMGLLSLTVVFATLVDYGGAYQTYYMERVCGNGSVVLPLSGSMGPESAVLVHATQSPSYSLALSCHVTVSAPKGHRVTLSVRLVDFRARWDGACEDYVTIRRINYCHKLYREDEDQHYDSDDDSIEFFYRTSGNNVTLSGFQGLQFTLTAFATGAPSSNESFSCANGHVVWSGLKCDGHNNCGDSSDEDRYGDAQCGGGGGDRGPDILIVLGLLIVFLLLVMCAATLFCTKNERVRRFSTRVRTGTLSFLRGAHRNSATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TG24</accession>
    <name>A0AAV6TG24_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005130">
        <property type="protein sequence ID" value="KAG8170617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TG24"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="165" mass="18176" checksum="9802C8C1939D1620" modified="2024-11-27" version="1">MIGRADIEGSKSNVAMNAWLPRASYPCGNSSDTSCIKLVKSKGSIGHAFAVRIHTENQDQASLLAFCSTREAVHLGDLLRIWVRTGTKITLSPSIFKGQQRRTGHRKRRGAFREQRPYLRTSRFQGHDSYKKDNSSPGPPSTSPSSVALPHLVPKDLSPCPVGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGJ6</accession>
    <name>A0AAV6TGJ6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004900">
        <property type="protein sequence ID" value="KAG8170785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGJ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="214" mass="23835" checksum="59C05CD167FFF64A" modified="2024-11-27" version="1">MFDSLTPLRPRSDDRFARQNRYGPPPEFPLASSCPGIVSPSFGSQRVRSNSATSTSGTRRSPVRPAREGTGSRMRPTSAGLYFHFAAGLIQDPLTRAHVRLLGPCFKTGRVEFTTRLRLHFQATRLQGDRIRIEPSSYGPRTHFGQQPRSRGLAAESVSGTLTPKRHISPRPCERGIRRWASPGSHSPLLRESLLVSFPPLIYMLKFSGLSRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THP0</accession>
    <name>A0AAV6THP0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004535">
        <property type="protein sequence ID" value="KAG8171048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THP0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="85" mass="9385" checksum="A3A8835687DFE8E9" modified="2024-11-27" version="1">MRSRLAQYAEVELGKQGGSGRDGEEPRPDEALPGTVVATHVGELARGDWRFKDSGWDQAKYQDFVATLVPPEKLGPHHQRSKQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THQ1</accession>
    <name>A0AAV6THQ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_014575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003997">
        <property type="protein sequence ID" value="KAG8171420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THQ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8171420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="188" mass="20416" checksum="428D844C5959C342" modified="2024-11-27" version="1">MLFKYTLSDEFPEDSNILKETPASNRIHCASHCLNEKGCLGFGFDTSKTCTLLSVHMKDNYCDSNSCVPRKDAKIYMSVPPPTTTTTEKPTTTTTTTETPTTTTETPTTTTTTTEKPTTTTTTETPTTTTTTKAPTTTTTTETPTTTTTTKTPTTTTKTPTTTTKAPTTTTTMKTTTTEVISIYFDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIF9</accession>
    <name>A0AAV6TIF9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003968">
        <property type="protein sequence ID" value="KAG8171441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIF9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10962" checksum="E051E9CAD384D44E" modified="2024-11-27" version="1">MPHLAASPDGLIHNGSNTMLLEIKCTFNVDRLELEELAERSNFCLVKTEGQWELKRSHRNFWLDMFEELNEFYLRYYLPALMAPEVDPAEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIT3</accession>
    <name>A0AAV6TIT3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003652">
        <property type="protein sequence ID" value="KAG8171707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIT3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22423" checksum="B8E63B3B57864308" modified="2024-11-27" version="1">MVNFGIFIRSTQDDLTIIEKCKNLLASIQSDTKILHVHRDKARGGLKVIFDTDSSVEQLLQRKDLDVTLTIHALTTALIVHEAFPNNEEEFKKSIRNKIVEKVLDIKKVPLSAKYPEIGTGKWIIILDVPEIEDLDEFKAMGLPENMMLLKLPNNDCKLKVEFYCRLCHKGGHVQGKCLEAPTSSFSNSGQNRFSEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKV2</accession>
    <name>A0AAV6TKV2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002698">
        <property type="protein sequence ID" value="KAG8172442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKV2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="219" mass="23522" checksum="62410B34780EE4D2" modified="2024-11-27" version="1">MQSDMEEDRRSISTITLSSTESLPPTRPNSALDYVRPHSALDSSARPHSALDSSARPLRSSSTRSMFLPPTRSPESAESAALRDLLSSGSPTSSSQSSSGDLWSDDMEWLSLSDISLSVSLSESDSDIHLTEPSISPPSISPPSPQPFPDPVPFFPIAPAPPQPFPDPVPFSPIAPAPISYRSSTIAAGTYNGRPIAVVRPFQPCCPCTCKITYYNRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TL76</accession>
    <name>A0AAV6TL76_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002831">
        <property type="protein sequence ID" value="KAG8172316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TL76"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8676" checksum="B0869A39A4286F70" modified="2024-11-27" version="1" fragment="single">MVQQRKRENLEFIKSLKFSELCQELEASANDGHTSLSDNATKKLLQCPKRSVGRPSKRASSCDLTPTRKSRRLLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLH8</accession>
    <name>A0AAV6TLH8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_015795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002720">
        <property type="protein sequence ID" value="KAG8172421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLH8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="84"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8172421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="305" mass="34716" checksum="E987A336B284067F" modified="2024-11-27" version="1">MCIPPKEMLAVTLRYFASGCSLGDFFYTYRIGTTTASQVVKTTSRAIWNALNKTHFHEATQGNWLDIANNFAKNSNFPLCLGAIDGKHVRIEKFPNEGSMNFNYKKFQSIVLLAVADADYKFIYVNVGGFGKDCDSNIFQQTSFWKLLTQKKLNLPDPAPLPPQGLKVPYVFVADDAFPMHEHVMRGYGGHNLTTKQKVFNYRLCRARRYVECSFGILTNKWRIFHRPLNLSRQSAVEVVKACVVLHNIVRERDGYRFEDLLACPLQPITNVTPTSRKTGRGIRTCYANYFVSNEGALSWQLSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNJ0</accession>
    <name>A0AAV6TNJ0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001760">
        <property type="protein sequence ID" value="KAG8173449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNJ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="342" mass="37391" checksum="ED24F893F9596D71" modified="2024-11-27" version="1" fragment="single">RKLSGTRRTPKNRLSGMPPSITPGGALGSPRCESPQKNAFRSQRTPKGHKGGAQRKSLSKQRSRASWRCFSRMQRNPVHGKGSDTLCAPGGVSHDVEGVLSWSSSSRKNFKGLTADSGNPPFGMDCTGLARESSRGHSPTRRTRALTDELEDLEFQFDDLRETRRKLGIWVTALPPVAPEGVNKKIEKFTDQVNRVFGLYLQTIADLDVSKGSSTQPLKDAFAAYGGKDGDMLPHKYVRLMTALQKDIYESNPELKPRVGGALYTHWGRGECPKDEEASVVGVMSASETSRMGGSSDFVCVQPDPIHPNPKIISKGRTIQMITYSSALSGTWARRVDSATCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRE9</accession>
    <name>A0AAV6TRE9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecto-NOX disulfide-thiol exchanger 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001395">
        <property type="protein sequence ID" value="KAG8173960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRE9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007624">
        <property type="term" value="P:ultradian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038876">
        <property type="entry name" value="ENOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001:SF4">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="41888" checksum="D98DA439A2A016CE" modified="2024-11-27" version="1">MRHEKEGLRPPSPPPIVNYSECEAATLGESLRNEDTFKQALEVLITWLDRGECNKRNAGTFYSMLQSTYSHVRRLVAEKTKIEDELTAVKQKLHQQSTANAQHFMDIESVFNHASAQKVWDHFTKAQRKHIDQWKRQTTDIKLQNLEDLLEERIEDEMEMSDSEDQKPPEESTEKKLELNEELAKVQEDKQKLQEEVEMLRNQLQATNNEMVSSKDENEKKITALSDTYQLMQQNYLETKKKLEETVKEKMALVSRKIVSLDKQQGGGNCVSASGAVTESEARLVSLIATFLNVHPLGASIDYICSYLVKMDRYITTRDVENLMMKFNTVFKEESTGIGATLEKKWIFYGYKFYTSPSSESIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRI0</accession>
    <name>A0AAV6TRI0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001253">
        <property type="protein sequence ID" value="KAG8174323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRI0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="179" mass="19885" checksum="587E4BC68DFE2084" modified="2024-11-27" version="1">MGTDRHENYTISLGFSRANRGAPDTARDAVLLREQRPYLRTSRFQGHELLQRKDNSSPGPPSTSPSSVALPHLVPKDLSPCPGWGILTPFPFGRQRDKHEHVFAFRQTSRFGTDFSDPLGPTDPCSTAVHMEPFPSFSPQGSHLSICYYHQDLHRWRLQAGSRPAPSTHATATLLLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRK9</accession>
    <name>A0AAV6TRK9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_029272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001271">
        <property type="protein sequence ID" value="KAG8174249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRK9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="110"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="370"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8174249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="585" mass="65538" checksum="627445373984B647" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRP6</accession>
    <name>A0AAV6TRP6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_026747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001259">
        <property type="protein sequence ID" value="KAG8174296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRP6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8174296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="303" mass="32961" checksum="BF82D477DCD1F891" modified="2024-11-27" version="1" fragment="single">MGERIHRLFDPDEKHHQPAPPCEDVPRKSPQEALAREGCRSRLFLSLLSGLPNEQDFVLGALAGLGAPLLSPRMLEVLVAQAGVWGPGAALGGLYSECWRGVEGRRMRLFWRATLHPPLCATLGVDAAAGEEEEPFLEPWELRAEGCRVTQVALILHNLSFEVQNVSVLVNSAIFIRFLLLCIHCSWANLKQIAFDTLANIAEEVVLCGGEEADRLLLGVVLAGVVSGDRFVALRSMDALAQMAPRNELLLVPRIDTQVCGRLVSLLSVRDVLLLHLALECLCALSELGRAPCDCIARTPGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSU1</accession>
    <name>A0AAV6TSU1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001204">
        <property type="protein sequence ID" value="KAG8174481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSU1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="9153" checksum="D9CE152D0615F26C" modified="2024-11-27" version="1">MCAKKKRKTAVVQLSCEENFTTELLYFSQYMKMVGMISWMQRFAYNSLHCSKKRRVNITSSRGKRKTVAVHPKGMFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSY8</accession>
    <name>A0AAV6TSY8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001050">
        <property type="protein sequence ID" value="KAG8175167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSY8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10959" checksum="83BFDEEE8389C835" modified="2024-11-27" version="1">MWRILQRGFKPNVRRLQLCCLPNPINFNYVGNILQHYMRSKEKLPRVKVTWGDNLVTGGMCSTTPCFKQKHFKTAKVFKTAKEDLRKEMMVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTX4</accession>
    <name>A0AAV6TTX4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001060">
        <property type="protein sequence ID" value="KAG8175139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTX4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000023">
        <property type="entry name" value="Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21497" checksum="7A055CBA7E9D5199" modified="2024-11-27" version="1">MYSSGQNLQLSWLSDCGNFWHVLVKQSAKKEICLFSIPEVEFLGFRVDKTGIHPSKGKVEAIQAAPKPENKQQLQAFLDLVNFYHSFLPNKASIAEPLHRLLDNDAPWNWSSDHTKAFNSLKQLISSESVLTPFDDSLPIVLMRPHMVSVLCWLTSCLMAGRHQSHFIHGLSRQLRGITHSWIRRHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TU97</accession>
    <name>A0AAV6TU97_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000996">
        <property type="protein sequence ID" value="KAG8175480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TU97"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="186" mass="20926" checksum="E390A73D0E9C0D74" modified="2024-11-27" version="1">MEISIGRKGNENQSTFDKNSSTLSLAATLQGRMWVPSSFQERAIKAEILILMHAIKCNYPFSKLGELVEICTEGFEDSTIAKNVYLSETKARYVTKFGLAPYFRKKVFQDIEDDAETGRPEGRRLLPLVTVADLLAMEVGFIVAPAFLRRGTLLPIVCSIVSHCPSVFIHVRRDNPFSKAIKWKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TV66</accession>
    <name>A0AAV6TV66_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_009122</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000975">
        <property type="protein sequence ID" value="KAG8175643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TV66"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8175643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="357" mass="40518" checksum="3DC78C4D466BBEF9" modified="2024-11-27" version="1">MRRTALCTLEPNKCQWNQSDFCIRYPKYCIKDQDPMNAVPRQGIETSHSFEYLNAVGQREEDLLNYCTIEADTDSPCINVVSQPAMKLEGFPNMCFTVESLWGQPDAQPRSIPVTAQVSVRLELHPEEYVVHKEPVKAHVLVHDPRALDNPNDEGLTLLSGKTYIIYLSQTVTKRQPAPFRTNCTDYLKLWRENGGRGPLTRKSCSAKCKMERSLQSFGCVPLGISYPNNNTLCNFYGAPSEIRDGCSRECADACTENTYHLRVEIQEEQSLKCPADDINCKQQDMMLFFSFNRFEVTTFMHEPKFESVSVFSYIGGYVGMWLGVSLVALFDLAETLVNLLVIYPLSQASRRKARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVQ3</accession>
    <name>A0AAV6TVQ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000948">
        <property type="protein sequence ID" value="KAG8175834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVQ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="371" mass="42648" checksum="850688214F8A3F68" modified="2024-11-27" version="1">MAPLTAAERQRKRREKLKKDGQYEEYKKKHSLLMKKHRQVKADKVSKLPVAVQKELKELEKKKVRERVAKCRRNKSVKQPTENKSSPKIYKSTSALGKAVARARRALPNSPRHKEILVRKLFSSECNIDLTTSFNSSKSTSNHANAINSDTKIKIEEFYERDDISRMAPGRKDVVTIWESGAKIKQQARHLICTINEIYIMFKIENPSAVVGKSKFFELRPKHILLSSKLPHNVCLCIYHENFINAVNVLHQHNDAVPNYSYAFPEEIICVPASRNCWMNECQLRPRHVLPSSKMPHNVCVCKYHAKMDFMLKAVPNLKIKAAELRNLSVCSQYNEDCMLSNCGACEDKIGEVLLDALDEDERAVEVFWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TX44</accession>
    <name>A0AAV6TX44_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_010771</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000866">
        <property type="protein sequence ID" value="KAG8176560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TX44"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44207:SF2">
        <property type="entry name" value="REPEAT PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44207">
        <property type="entry name" value="SURFACE ANTIGEN BSPA-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="8" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="9" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="288"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8176560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="562" mass="62611" checksum="C30C8C79DAFBD498" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXC7</accession>
    <name>A0AAV6TXC7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_020759</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000890">
        <property type="protein sequence ID" value="KAG8176361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXC7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000004">
        <property type="entry name" value="Cryptochrome-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="8">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="496"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="297"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="395"/>
            <end position="397"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8176361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="540" mass="62434" checksum="77C38F9C9854E31E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXF4</accession>
    <name>A0AAV6TXF4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000928">
        <property type="protein sequence ID" value="KAG8176004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXF4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="123" mass="13982" checksum="C5AAF4E0E9E8315E" modified="2024-11-27" version="1">MLLPNSKTICKHGRVLEVVEYQGNVTHCCEKECIPIPDRVIRGLACSKCKAVNYCKCKCISWEATKRKYLRVPLIKPEEGWQAVRLNTEIESIANAVESSPESLTNDLNDLTESSEDFLIYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0D2</accession>
    <name>A0AAV6U0D2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_016890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000823">
        <property type="protein sequence ID" value="KAG8177061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0D2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF83">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="918"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="139"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="378"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="974"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="992"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8177061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1012" mass="117077" checksum="60D83CC728E64382" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0Q7</accession>
    <name>A0AAV6U0Q7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000722">
        <property type="protein sequence ID" value="KAG8178042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0Q7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="987" mass="111801" checksum="FF0101DC01581019" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2T7</accession>
    <name>A0AAV6U2T7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000668">
        <property type="protein sequence ID" value="KAG8178767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2T7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="9142" checksum="40960FAD09FECBE5" modified="2024-11-27" version="1">MDKTGVERLLLVVPKRYRNDLKAFCHEGTSGHLGVTKTKDIFSRHFFWPQCYKEIEDYVRSCADVNALENLLAKRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4E2</accession>
    <name>A0AAV6U4E2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_012545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000647">
        <property type="protein sequence ID" value="KAG8179136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010000647">
        <property type="protein sequence ID" value="KAG8179137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4E2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="25"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="5">
        <location>
            <begin position="370"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8179137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="507" mass="58184" checksum="F2AA86168B07796A" modified="2024-11-27" version="1">MKDNLSKRDLYPRVADFYNGKSVFITGAAGFVGMIILEILLRTCPGIRSIYILIREKKGVKPEQRKEKLLQKVIFDQLKAEQPDALDKVRLVTGDVSEPDLGLSEEDTDRIIQDVSIVFHCAADLSFVKSVKYLMGINTMGTYYVVELCKKLKQLEALVYTSTICSNTNRCEMVQEVVYRLPFPSEIFVQEFRKGTEESVEELSNQCYPRWPNGYTFNKCLAENILLENAAEVPSAIIRPALVAPIWKAPHPGFCERNSTMTLLCEGVGKGFIKVLLVDPDNYVDFVPVDIVANSHIVAAWKVATQRCQIPYIVNCSTYGTSSDTWESFKNILLKILADIPVMPNSFRTRQDCFFTQNPLLYKIVCFYEHYVPAYVIDLLLKFSGKKLRLVRLYDLFDKAMKTATFFTIKRSTYDTANFRTMENDLDEADKEIFYTDCTVAPIEKLALSFPTGNDVFDWKLDKRTKESRMKKATQLHRFTLFLKYSFLVIMFTMVYYVTSTVYQLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4K7</accession>
    <name>A0AAV6U4K7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000670">
        <property type="protein sequence ID" value="KAG8178748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4K7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="133" mass="13905" checksum="9A312083BDD0AB4E" modified="2024-11-27" version="1">MGCHLPPIVQQAGGPVRVWSGGAGGVGWRTSCWRAAEFGSAEPAEFGLAEPAEFGLADAGGVWSGGGRRSLVWRTPAEFGLADAGGVWSGGRRRSLVWRTPAEFGLADAGGVWSGGRRRSLVWFTPVFGPGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5I6</accession>
    <name>A0AAV6U5I6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_025970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000601">
        <property type="protein sequence ID" value="KAG8179802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF49">
        <property type="entry name" value="AXOTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1652"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="5">
        <location>
            <begin position="101"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="290"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="5">
        <location>
            <begin position="331"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="5">
        <location>
            <begin position="520"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="695"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="7">
        <location>
            <begin position="732"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="5">
        <location>
            <begin position="940"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1112"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="5">
        <location>
            <begin position="1156"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1358"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1791"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1795"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1366"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8179802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1839" mass="206657" checksum="EF79CE53D4036F4F" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6L6</accession>
    <name>A0AAV6U6L6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 21">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="21">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">JTE90_002828</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.</text>
            <dbReference type="EC" id="3.4.15.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 20 21">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="21"/>
    <dbReference type="EMBL" id="JAFNEN010000603">
        <property type="protein sequence ID" value="KAG8179789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6L6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1370.30:FF:000004">
        <property type="entry name" value="Angiotensin-converting enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF45">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 21" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9 18 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14 21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 21" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 22" id="KW-0732">Signal</keyword>
    <keyword evidence="7 17 21" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043316539" description="Angiotensin-converting enzyme" evidence="22">
        <location>
            <begin position="20"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 1" evidence="13">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 2" evidence="15">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 1" evidence="13">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 2" evidence="15">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="14">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) (complex) asparagine" evidence="14">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; partial" evidence="14">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18 20">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-10"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-11"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG8179789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="626" mass="72231" checksum="9EDD78C1B54182DF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6P3</accession>
    <name>A0AAV6U6P3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_016498</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000575">
        <property type="protein sequence ID" value="KAG8180222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6P3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8180222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="497" mass="55909" checksum="7BD537E7A011DBAA" modified="2024-11-27" version="1">MELSNKSSREHSKCVMSCEAIGKSSVHALSQLSQAKSSCARVFWLVVFVVTVSGCAYQVYSFLNVYLQYQVLIDLKYQRVMALDFPAVTVCNLNGITLNHIDCVNKSLIWDQCHPSPTQTGSVHGSGGSVSYIGGSGGLPLYRTLSYSLTSTSNTSELQKSYNELAKNLLNRYSKLDGMSRRCYGHRLDDFILKCSFNSVTCDYNDFEYFLSKQYGNCFTFNRKSENDLNAKPRIVKRAGPQSGLELVLDVGLNSYSKVTPSFGVRVVIHNPREDPHPSQKGVNIPFGVESHLSLAKTSFHRLTSPYRDDCKNYPPTGGLNCVDECIQRVSMKLCGCADPFLMAALPKKVLCNLLNETQTACMGRVLDLLSSNVEERLHTCDCRLPCFSTEYDVQLQNMVMNRALVMRSVKSDRHFGKSYEPEECRGEKALMPPTKLKVFFKTLDHKIYVQKPMFSYSELYSQLGGNLSLWLGLSFVAMYEFAEKLFLFVKVALHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U825</accession>
    <name>A0AAV6U825_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_025072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000605">
        <property type="protein sequence ID" value="KAG8179739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U825"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14692">
        <property type="entry name" value="bZIP_ATF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="252"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8179739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="320" mass="35434" checksum="39AC40D3A76DEC17" modified="2024-11-27" version="1">MAFFHNVVSTTPSVFLVPNDYGFNFDEILRSSNKTNDDADLITGLPDLDWLDAQADLSVLDESKGFNIQPFEIEDPLNPDDADLLLDLIDNSILNASYLSSDLCKANLQDILSSSTHIEQPIASSKVSDLPMSLPFYEPICEVSSPTSCTSGSVCPSPSGSSSIDDGFYESISEASSPASFADSAGVTVTVCDMDVTSIKAEPMCLDEVTQSVRRRKYVRDNLKEIPKVKVTLKDAFHPYAKAAPSKRSLGKKERKKVQNKEAAARYRIKKRIEEGHLSGEVEDLEKEQEGLRKKHDDLLSEIKYLKNLMKEVLQKKGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8M9</accession>
    <name>A0AAV6U8M9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000596">
        <property type="protein sequence ID" value="KAG8179949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8M9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="82" mass="9745" checksum="FAF87EEC107860E3" modified="2024-11-27" version="1">MVPRSRKRQKTVEKSDRGDRRAFMKFENYGVSRDFYHHPRMVNYSKEMKSKLRKMTGVATDLMDLIDIYEGEPSITGKKRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBI9</accession>
    <name>A0AAV6UBI9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_016606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EPS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000536">
        <property type="protein sequence ID" value="KAG8181093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBI9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01210">
        <property type="entry name" value="PTB_EPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11764">
        <property type="entry name" value="SH3_Eps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000289">
        <property type="entry name" value="Epidermal growth factor receptor kinase substrate 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039801">
        <property type="entry name" value="EPS8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055093">
        <property type="entry name" value="EPS8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033928">
        <property type="entry name" value="EPS8_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035462">
        <property type="entry name" value="Eps8_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013625">
        <property type="entry name" value="PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF23">
        <property type="entry name" value="AROUSER, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22975">
        <property type="entry name" value="EPS8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08416">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="597"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="547"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="668"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="769"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="807"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="840"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8181093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="994" mass="114068" checksum="DFB46C039A42E953" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBM1</accession>
    <name>A0AAV6UBM1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000539">
        <property type="protein sequence ID" value="KAG8181031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBM1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="256" mass="28856" checksum="F56440B925C0C1C9" modified="2024-11-27" version="1">MPVGYDVKARGHLGSNTSIPSVVTIWNEKVFPTSWQRAIVIPIAKPGKDPQDAGNYLPIALTSCLCKLMERMVNARLVYCLEEKGAFSPFQSGFRHHRSTIDNVLLLETSIREAFVRNQHLNFLKTRVFQVRVGSTLSRDFYQREGVPQGSVLSVVLFILLINGIVEQLPPAVKGTLFVDDFQISCASTNMSTVERQLQIAIRKITDWTNNNGFVISNQKTICMHFCRKRGLHLDPEIILNGVALPVRSEAKFCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDV3</accession>
    <name>A0AAV6UDV3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_019692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000454">
        <property type="protein sequence ID" value="KAG8182667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDV3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="293"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8182667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="559" mass="62641" checksum="D5B44F79500E9E8E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEJ6</accession>
    <name>A0AAV6UEJ6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Multiple inositol polyphosphate phosphatase 1</fullName>
            <ecNumber evidence="4">3.1.3.62</ecNumber>
            <ecNumber evidence="3">3.1.3.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2,3-bisphosphoglycerate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_026895</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27381"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="3.1.3.80"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:27382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. MINPP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.62" evidence="4"/>
    <dbReference type="EC" id="3.1.3.80" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000486">
        <property type="protein sequence ID" value="KAG8181955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEJ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034417">
        <property type="term" value="F:bisphosphoglycerate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000014">
        <property type="entry name" value="Multiple inositol polyphosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF8">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="137"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="482"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8181955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="515" mass="59128" checksum="9937CDB7EB7AFD52" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UH94</accession>
    <name>A0AAV6UH94_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000430">
        <property type="protein sequence ID" value="KAG8183153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UH94"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="619" mass="70702" checksum="A805870C1593EBD4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJE0</accession>
    <name>A0AAV6UJE0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000400">
        <property type="protein sequence ID" value="KAG8183888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJE0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="66" mass="7153" checksum="47F83AC1AC076A87" modified="2024-11-27" version="1">MQLASSSGASDGRPPPSTPPVLGLISSDRDQQAIGYIGRAAKFHRSPMNMALVGMGWLNGMRWYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKG8</accession>
    <name>A0AAV6UKG8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000404">
        <property type="protein sequence ID" value="KAG8183796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKG8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7980" checksum="56075F0DD11B4F0B" modified="2024-11-27" version="1">MIRMPWKFILEKFHQESRALTNQKTSYCRVRVFPPSRRTFPLALVSGTCQPQTILDKEVKWNSRTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKH3</accession>
    <name>A0AAV6UKH3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_015472</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000361">
        <property type="protein sequence ID" value="KAG8184789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKH3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14881">
        <property type="entry name" value="MYSc_Myo20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036029">
        <property type="entry name" value="MYSc_Myo20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF498">
        <property type="entry name" value="DACHS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="85"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8184789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="992" mass="109929" checksum="019F0529B1879568" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UL06</accession>
    <name>A0AAV6UL06_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000354">
        <property type="protein sequence ID" value="KAG8184902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UL06"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8192" checksum="EFC1B5356F32864F" modified="2024-11-27" version="1">MKYGRAHEEDALQDLQEAIGQDIRPCGLFVDKSMPFLGATPDGLTGTYGIVEVKCPPSCENLTPEDAVSTKKFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UM10</accession>
    <name>A0AAV6UM10_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000335">
        <property type="protein sequence ID" value="KAG8185452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UM10"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="104" mass="12132" checksum="A3A4E14B67BB6F72" modified="2024-11-27" version="1">MDIPVYHYTPCTQSGHFLKRWEYAGSRDRPAVAIFMTSGRRCQITCLPETMGSDVGTWRRLRNAMGAIEFRVNFEHRSNVASSFRMFDLVDMIKDLDVRGRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMP0</accession>
    <name>A0AAV6UMP0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GCF C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_012863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GCF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000333">
        <property type="protein sequence ID" value="KAG8185526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMP0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCF C-terminal" evidence="5">
        <location>
            <begin position="539"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="473"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8185526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="856" mass="98318" checksum="48850712138EC74E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMR0</accession>
    <name>A0AAV6UMR0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000371">
        <property type="protein sequence ID" value="KAG8184531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMR0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8673" checksum="C636277F116279E7" modified="2024-11-27" version="1">MVRPVYMLKNSVCHDEFLHHLKVCCYFRNSYRSYVMCQRSTLAEYVRGVCWSTQRLHNLVGLGMKVIEPVNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNC6</accession>
    <name>A0AAV6UNC6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000320">
        <property type="protein sequence ID" value="KAG8185947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNC6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="157" mass="17475" checksum="71720991A30C6377" modified="2024-11-27" version="1">MMCWGAHNSRLDDMLARRPISAPPSQFVRIVTTLLLLLKKHALVVNIYRGGGSRRYIGKTPFPLTCQLKNYSLSEYFVFCGLCLLDSGDMLMGSMPPAGKLPNNPPGASAMIYFGSINVTKTNRKHRPVKNLILAQKPFPTKAEGGPREKKIDKTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNU6</accession>
    <name>A0AAV6UNU6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000320">
        <property type="protein sequence ID" value="KAG8185944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNU6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="135" mass="14699" checksum="2016D0842222BC16" modified="2024-11-27" version="1">MKKKVFNSHTGSPIRSPIRLAVIGVQVAATHTNATSRYSLLSSDYAPTFKLFMNSDAQFLQQRLFISYPPSHTPPTVKAKPLDLWLPSVDSCVLAKMKQTQTQVAYLLGGGLGSCCQGGLLSEEVREATLLQNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPH8</accession>
    <name>A0AAV6UPH8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_019757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000334">
        <property type="protein sequence ID" value="KAG8185501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPH8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043473532" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="153"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8185501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="509" mass="58281" checksum="85C6CD0E1BB53D12" modified="2024-11-27" version="1">MEFSCLLLLSIILFSYANIINKNVENDNEDFPEFKGILVDERVSLKTSQIVRSKSSNSNNELDLNNFFIEHYERRIESPFIDDIGFFNEEMLFANNIGFGKRTIELDLTNRLKQKDLRFRPDGINNPDKDFDTFDVSLSESKIDTNFDDLSPEERKEIVKDHIKYRSKFNTYAPMASDMKYMEYSEFLEAKAKDYVQACKYDKNTSYGLNVYIGTSRNFSRAMRLWYSESKWYEFKNISCSKGHMCGHFTQMLWADSHLVGCARKSHCFPRYSGHILLSCFYLPAGNYLRFPPFRVGLPCTRCTTENGNLCHEQLCVTKRQCEDHSLRCSCKTECMNCAVPNPSTCRCEACRPGWDWEDCSIPCGDELNRIGKNCPTSGKNTFCVEAIPGKLCRKSCGFCEVVNSSKSKEFCCGGKICDPYHVLDSSCKCVLDCPSALCLDSISSKNHTSLKPKNFASDTFDKPSNVSSCLFETNENLYKNSVSKVYGFHLSVFSCFEIVICLLQIKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPN0</accession>
    <name>A0AAV6UPN0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Amiloride-sensitive sodium channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_002764</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000342">
        <property type="protein sequence ID" value="KAG8185236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPN0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="455"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8185236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="57443" checksum="E9C09E63CDFE7E86" modified="2024-11-27" version="1">MHWETPNPTQDNKDPPLNGVEMRSRNLWFFSQEVFSKSSLSGISQIAESRTWTRRILWIALFASCILGFFYHATTYFSLYAAYPTTVDVRVDNKGVLEFPGITLCNNNKLRKSLYCAEYHCNSNDNMQEYEDYWRMNKSDRIRFGYTKERMILKCKLNGRMEMDEDQCYKHFRLFHNAEHGNCYTFNAQWNMPDHKVLYAYESDMWNKPTELLLDLDVQTEEYLDDHKTPSVLIYVHDPRFYPDFGSEAVKARAGHFYSTTTKLLPLPYQTNCTTYNAMPWAMRNKGTLTPKMCTQECSRSLQLKACKCVSSNLTLVFEDSPCEGKKAFCAEDVEKNTTDYCRTLCRVPCERKTFEAAVDSSVWPRKKQVFTIDAWSNKNLTEIRKNLVRIKIYLRTMEITMYEHQPKYELVEVFSHLGGYLSLWLGFSVLAFCELLEMVSMVILRITDVKTTTGPHRVPRRHTRRNRVQNRTEHMAPSRSVNSIFREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTA9</accession>
    <name>A0AAV6UTA9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Diuretic hormone receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_022888</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Receptor for the insect diurectic hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000270">
        <property type="protein sequence ID" value="KAG8187495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTA9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008036">
        <property type="term" value="F:diuretic hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15263">
        <property type="entry name" value="7tmB1_DH_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000155">
        <property type="entry name" value="diuretic hormone receptor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002001">
        <property type="entry name" value="GPCR_2_diuretic_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF15">
        <property type="entry name" value="DIURETIC HORMONE 44 RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01127">
        <property type="entry name" value="DIUHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="14">
        <location>
            <begin position="32"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="15">
        <location>
            <begin position="128"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8187495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="460" mass="51482" checksum="CC8E3CBBBAE659AB" modified="2024-11-27" version="1">MLQENENSIKSANNVSIEKDPFEDIGSLEEADCYLDSLSQEYPDDGKIYCNVTWDGISCWPITAAGSPASVPCFEEFNGVRYDTNTNASRECLSNGSWVPWSNYRGCKPLTHEDDLNDFKVLWDMKEAATIYYVGYGISLVALSLALFVFFHFKDLRCLRNTIHTNLMITYLLLDLTWIITATLQSNSNPSAAKVACILVILLTYLMATNFFWMFVEGLYLYMLVVETFSIDKIQFRTYVAIGWGIPAFVAAAWAIVKGTAGGAAEEPLAQRGCPWQNKDYYDYVFSCPVMLVLLINIFFLAKIMWVLITKLRASNTVESKQYRKAAKALLVLIPLLGVTYIVVIATPSDPVAEVVFIYIQATLLSIQGFVVAVLYCFLNGEVQNSLRHHLERWKIQKSVGKNPRQSVSQASPHHGESIALYNGRGARESCTSFSTTTTVVNLTKKSGSSHHLAVQDDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTQ4</accession>
    <name>A0AAV6UTQ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox protein unplugged</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_000173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000262">
        <property type="protein sequence ID" value="KAG8187707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTQ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051960">
        <property type="term" value="P:regulation of nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000360">
        <property type="entry name" value="Gastrulation brain homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042982">
        <property type="entry name" value="GBX-1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24334">
        <property type="entry name" value="HOMEOBOX PROTEIN GBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24334:SF0">
        <property type="entry name" value="HOMEOBOX PROTEIN UNPLUGGED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="143"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="145"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00068822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8187707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="249" mass="27321" checksum="D161CD5BC5A0B320" modified="2024-11-27" version="1">MQRASFSIDSLMSGSTAVNPGFRSHPAFQFPFFYNGYVFLPRSGLYPAGFPGQTDHLLAGQPRLSFPDIPLDCRAAGYTTAASPSSTTSNRSSIFDLQHSPTGFSNTTRDSSSSSPDVTALDMDEGGSSDDEGGKTRGDDGEKGGRRRRTAFTSEQLLELEKEFHAKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRVKAGLASGRIGTSNGNNGPKIVVPIPVHVNRMAIRSQHQQIEKTLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUE8</accession>
    <name>A0AAV6UUE8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_009495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000272">
        <property type="protein sequence ID" value="KAG8187419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUE8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06592">
        <property type="entry name" value="GH31_NET37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF4">
        <property type="entry name" value="MYOGENESIS-REGULATING GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="5">
        <location>
            <begin position="283"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="6">
        <location>
            <begin position="593"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8187419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="678" mass="78257" checksum="46B89B02B91D8EF9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UV27</accession>
    <name>A0AAV6UV27_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000264">
        <property type="protein sequence ID" value="KAG8187659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UV27"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041404">
        <property type="entry name" value="DUF5588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31919">
        <property type="entry name" value="ZINC FINGERS AND HOMEOBOXES PROTEIN 1, ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31919:SF1">
        <property type="entry name" value="ZINC FINGERS AND HOMEOBOXES PROTEIN 1, ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17826">
        <property type="entry name" value="DUF5588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="350" mass="39649" checksum="52D960C5BD321576" modified="2024-11-27" version="1">MEFGADFDDDFFEEPKERHLNGPAKYEPKVFKPLWFMDTDSNQKSEEEDALHALKHQADHHYSRKCYSKAAETYERCLGMVPPGTNTTWRREFMENIARAHLNMGQPEKALEWSFELDKSSCNADQKIVSMNLLAAVCHKLKKYAEELEALHCCLEAHKLCPEFWQRLALCYAGLFKLRLPDFPSTPDQEPEDEELCCDFKAKRSPLLQGKDKCSKSASAEELLPSPNSDLVCPSLEGDRLTAASEETCTESSKCELCMLGIQIVSSCLIRTRMLMDSGGPSHLTAQRDECLKEKIANCLKHMEVDQDFIDVASQMLGGEFSTILQRPDSTLDQHSSLLNHKEQDPTDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVN8</accession>
    <name>A0AAV6UVN8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000257">
        <property type="protein sequence ID" value="KAG8187869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVN8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043473533" evidence="1">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="10917" checksum="5D92C991C73B95C5" modified="2024-11-27" version="1">MVNTKIFLLVTVTALVAFVALSEAAHSPEPLVARLRRQIIDSSTAQPGTDVTTTAPTGGNQGIVATIISYVWPFLMYLPFLQPFILAYRGFTFIYGFFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWA6</accession>
    <name>A0AAV6UWA6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sodium/potassium-transporting ATPase subunit beta-1-interacting protein</fullName>
            <shortName evidence="7">Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_002455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NKAIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000249">
        <property type="protein sequence ID" value="KAG8188102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWA6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002028">
        <property type="term" value="P:regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008516">
        <property type="entry name" value="Na/K-Atpase_Interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13084:SF6">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13084">
        <property type="entry name" value="T-CELL LYMPHOMA BREAKPOINT-ASSOCIATED TARGET 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05640">
        <property type="entry name" value="NKAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8188102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="265" mass="29858" checksum="AF1FB00059CF2AD1" modified="2024-11-27" version="1">MLIQIKYTIWNAIWLGWNIFVICIYFEAGILSRDTDILNMGTGSRSWWLVNGVGCIPLYNTTHDDPFTFPTPTTVEGCAVEYFYIEAVQASLQCILAVLGIVAACSTIYIFTREDDSFDFIGGFDSLSSYHSPAKASQMCSTKQVHSLPYSIEYHNNTSPADLNMAAQRPMTPRKVKQRSTRSKRGSRRRYQNPVTKLINSNNQNNFNNAPMYSSQPNNLSNDFYPAHANQAFSMSETEGSRPNSMYLNGGRPSPIYMNETDTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWW3</accession>
    <name>A0AAV6UWW3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000225">
        <property type="protein sequence ID" value="KAG8188985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWW3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028022">
        <property type="entry name" value="DUF4600"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28671">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28671:SF3">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15372">
        <property type="entry name" value="DUF4600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="269" mass="31721" checksum="272E99398B007A82" modified="2024-11-27" version="1">MHGYWLKNRSLNEYNMYSRRQSKAVSSKAVLDSGKDVETLRSEIENEQRMTEMLDLSIDELQRTIDALEQQVDHTDIADEDEWKVRYYTQVEVNEQLERQRDWLMERVEAARNQSQEGVSALLAELDLDSLTESQLLRYLKQLEKDRNSLYNELRDKEWKLDQESKTFHKYNDTRKAYMTEITEAMLNLEAMKSRLRTFEGSENGSIAKCPRHLKYLNILPDQRVIDPRKGPIRKTAAVRSLPKLNTADKDFIDDDDMLDKQSKKSAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXB3</accession>
    <name>A0AAV6UXB3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secernin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000244">
        <property type="protein sequence ID" value="KAG8188289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXB3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.60.10:FF:000001">
        <property type="entry name" value="Secernin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF17">
        <property type="entry name" value="LD30995P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="47748" checksum="32C4A5B283EA1C9E" modified="2024-11-27" version="1">MSTKKPCPQSCDTFVALPPATALDCVVFGKNSDRPKGEVQEVVYFPAENHPEGTKVQCTYISVDQADHTHAVILSKPAWMWGAEMGSNEVGVCIGNEAVFTKLCGSEDIEERLLGMDLVRLGLERSSTAREAVDVITSLLEKYGQGGPCSDTKTDFTYHNSFLIADRKEAWVLETAGKLWAAEQVTSGCRNISNSLTIETKIDLMSDGLKEHAQANGYWDPSQGDLNFAAAYGKENESAVQRFNGGKQLMEKLAASGEFSTISMFEVLRDCESGICRGLDHEFPTAASQVSALPPPDSQRSSCHWFTGTPDTAHSVFKPFIFCSSNRISRHIVSPTYPDNEDPAKVKPRFQKEINRSHTLYTKHQKAYPILTSDNPKGKEINTELRRLETQCVKDMEGFVENFTSDKAKEVEDIFKDLVESEMKFYYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UY47</accession>
    <name>A0AAV6UY47_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-phosphoxylose phosphatase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acid phosphatase-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_025503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-O-[beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:56512"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="Rhea" id="RHEA-COMP:14559"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="ChEBI" id="CHEBI:140495"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000222">
        <property type="protein sequence ID" value="KAG8189074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UY47"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8189074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="515" mass="58363" checksum="9747E2BF57E624E5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYG9</accession>
    <name>A0AAV6UYG9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2HC/C3H-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_019052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000218">
        <property type="protein sequence ID" value="KAG8189292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYG9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8189292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8171" checksum="D265EF1134E98D60" modified="2024-11-27" version="1">MDCAVMALSTRLNDEDVASLAELGNNAWESHLQRLVPCPLCSRTFFPDRLGVHKRSCKGPPTTSSRRPRSKMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0I6</accession>
    <name>A0AAV6V0I6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_008455</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000213">
        <property type="protein sequence ID" value="KAG8189493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0I6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF296">
        <property type="entry name" value="DEGENERIN-LIKE PROTEIN DEL-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8189493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="247" mass="27705" checksum="3EA36741AA126505" modified="2024-11-27" version="1">MDLVSPPNIEKATEKGFIVFLDDPLNVIIDDKRIKGQRAPPGLVTTIKSELIRFQRSALYTAWHGGTTHCPKMPKGVMIKNDPERFSLHGCGAFYLAQMLMKTCGCKWLLTEDFPDVKYCDPAQQYKCILPSCLKTNLTEVSKNCLDPCISYHYRADASYVGLGLSNTSRIEIVYNAKQYISLEYRTTTLSGLFSQVGGAMGLYLGASIITFAEVVIFAVSWLWYRIVPSTSPVLPMHHTKKMLSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V148</accession>
    <name>A0AAV6V148_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_014432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000186">
        <property type="protein sequence ID" value="KAG8190326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V148"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11418">
        <property type="entry name" value="bHLH_TS_ASCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000029">
        <property type="entry name" value="Achaete-scute family bHLH transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8190326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="199" mass="22699" checksum="2D9A14EABA7CDCBD" modified="2024-11-27" version="1">MMSMEQNHMHRMLSSNEDTRRLLYLSSLNRPHAVSQGIREIPSQPHRQTIPDLSGTSQTNHKRLTDHQNHPKRLTYHQTGIVPNNPVSRRNARERKRVRLVNLGFSTLRERVPSKNKKLSKVETLRAAIEYIRQLQGMLGLPDSQLFEDCSSSETSGQPGGSGNLSPASSHPSECSLVPYENMHQHQEDQLMDIGLWFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3L9</accession>
    <name>A0AAV6V3L9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000183">
        <property type="protein sequence ID" value="KAG8190466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3L9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8099" checksum="699D327833149A9F" modified="2024-11-27" version="1">MRIPLARWLPSGFPRKRPLDELVPLSSIKCTLDGYSQKKKEYNAQVTAEGKSQSFLKGKSSASMGFIIFCFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4B0</accession>
    <name>A0AAV6V4B0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000162">
        <property type="protein sequence ID" value="KAG8191272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4B0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF29">
        <property type="entry name" value="PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="152" mass="17748" checksum="17FEC2505843F70C" modified="2024-11-27" version="1">MASLLRDCEEFAVPYLDDVAIFYNTWEDRVKHLEEIFVKMKTAKLHLKPSKCQFAREHVKYLGHIVGQGQRKPGELKIQAVKEFPRPQNKTQIRSFLGLAGYYRRYIPDFSILVHRFSVYLKAVLAKDNNKKLQWTISSAFALFTSVYCTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4G5</accession>
    <name>A0AAV6V4G5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_005826</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000174">
        <property type="protein sequence ID" value="KAG8190790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4G5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000002">
        <property type="entry name" value="Solute carrier family 41, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="127"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="338"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8190790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="498" mass="54022" checksum="42B7A13C94033242" modified="2024-11-27" version="1">MVPRAASEGDQLIISDSSDEKEFANLTEFGKPDIINALVPNALDKDSKPVSWTFDGDQSGTDNESHRSLLEEQVVIPDTKETMLAIALQVFVPFLIAGFGTVGAGLVLDIVQHWDVFKVVSEIFILVPALLGLKGNLEMTLASRLSTQANLGHMDTSKEQWKLASGNMALIQCQAIVVGFLASLFAMIMGWIPEGKFNLEHALLLCAASLVTASLASLILGCIMVGVVICSRKCHINPDNVATPIAASLGDLTTLSLLAGISYVLYGKLDSPGFPITIILFFLLLLPFWIAVARKNKYTREVLHSGWTPVISAMAISSVGGCILDFAVDRFYGIAVFQPVINGVGGNLVAVQASRISTYLHQRSKLGVLPVEDKDLCKDPISAFFGKSVHSTTARVLMLMVVPGHLVFTYGIRFFNAGHTSVTAMFLTFYLLAAIIQVFLLLYFAHVMVHWMWIKHIDPDNSAIPYLTALGDLLGTALLAAAFVILYELGDKDFDVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4X6</accession>
    <name>A0AAV6V4X6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000156">
        <property type="protein sequence ID" value="KAG8191599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4X6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="11921" checksum="194751C6BBA1BDDA" modified="2024-11-27" version="1">MIKDRKPKVGFLPQSCKEELLVPKSSSNSKENNNSRSDDCNDIYEKDKTRLQPKILTLSKTVAKVLMNPSINVSVCIPKENTKTETFSTFVEETQFKMSESEAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V503</accession>
    <name>A0AAV6V503_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000155">
        <property type="protein sequence ID" value="KAG8191629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V503"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7702" checksum="91117F15A2AF5712" modified="2024-11-27" version="1">MLPTRIQKSRKTWLDYLSASSRALNKERDVIKGQAYQKGANDKQAGRNLRGHAERLRYMISIELGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V847</accession>
    <name>A0AAV6V847_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_025309</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000146">
        <property type="protein sequence ID" value="KAG8192043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V847"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="47"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8192043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="128" mass="14309" checksum="C5A63073839AC927" modified="2024-11-27" version="1">MADPTNATMTTNYSQEEINQSLEALGPKMQIFLIVLYSMTAMMALAGNATVIVVLLLGKRSSRELRIFLINLALSDVCMALFSIPFTYTDFMLGRWIFHPGFCPFVQFMQHVSVVASVYTLMAIGVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8V2</accession>
    <name>A0AAV6V8V2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_025616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000133">
        <property type="protein sequence ID" value="KAG8192907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8V2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8192907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="111" mass="13045" checksum="4D633F8D023081EA" modified="2024-11-27" version="1">MPFTPNMSNYAYRMARLSARIFGEVPRPTTSKSMKVVSFMSQRPRDLDPEVVNLYPPHVEYGKLIETLRDHGLFRDEHLDFKEEMVRQRILRGKIKPKKGEGKRAKNKEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAR3</accession>
    <name>A0AAV6VAR3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_005061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000115">
        <property type="protein sequence ID" value="KAG8193765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAR3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8193765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="139" mass="15651" checksum="F30E2A1F53727FB0" modified="2024-11-27" version="1">MADRLSQLQDAVNAQAENICNSIGVLQQCAAPSTFTEFERTGPKPPQPPEDYCQTFATLICKTAKDIDVLIDSLPSEDSYPELQEASIRRLDEENKEAARRLEESVVKGEYLLEHIRKVLCDIAQSQQELQKINSIQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBY1</accession>
    <name>A0AAV6VBY1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_006982</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000128">
        <property type="protein sequence ID" value="KAG8193151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBY1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="11" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="96"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8193151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="244" mass="27131" checksum="5273D32795A97BC7" modified="2024-11-27" version="1">MMPHAAKKGDLEMVKHLIQRGMWVNIGDHYCRTALHRAAQLGHYEIVKYLISCKSELNFKDRAGNTPVLLAGDAGKKDVVDFLLKCGARANCANGDKCTLLHFAAGNGWEDVEQEQEVVDFLLECGARVNCTNDDKCTLLHFATGNGWTDVVGRLLKYEEIDLNATNQEGESALMWAARDGRKDVIAILLRVGADVLGKRRLDLNLQDRFGRTPLHRACYKGHLAVLRQLLESFIGMAPTVDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCU4</accession>
    <name>A0AAV6VCU4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCU4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="129" mass="14293" checksum="FC90A2973CC7606A" modified="2024-11-27" version="1">MLSSSDTTKDADHEEENSSSDENLPSIQKTFVAYVNLSRSEDGKIDADSVQKWFLKASIPGLYGADVKKYFSKKGGLDFNEFQEGIEKLAKENNEDKEDIVKKLASALPSGGVIEKEEDAQAKLDDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDC9</accession>
    <name>A0AAV6VDC9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BACK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_004998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000115">
        <property type="protein sequence ID" value="KAG8193698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDC9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BACK" evidence="3">
        <location>
            <begin position="115"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8193698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="277" mass="32076" checksum="78C3206AEEAF41FB" modified="2024-11-27" version="1">MAKTFRRLLNNLTFCCAGRNKTTIDESEYFNIKTVDKKTSKEQPTKTRHPQITAFDLNNPFIIPEIEVINSLIEDLYEEKEKELVSNSRIPAIYKQINIKMVELIDLTSDNMEFLLNIYKTANTVGARRAFRSAAKALALHFNNLVADKSFLNLSLNQLTTILRQEKIATKSEIDLFQAAVYWINQDYSTRQHLAIDLFRFINFSALTMPELMQCYSYQPNLFQSSEVDIILRNAATYISLKYLNKELTVFAFAPNPREFTIRPETSNPFEPVNPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFK0</accession>
    <name>A0AAV6VFK0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000098">
        <property type="protein sequence ID" value="KAG8194788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFK0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="212"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="360" mass="41332" checksum="AC7679D5B754268E" modified="2024-11-27" version="1">MTSSLWWNGPNWLVQEESSWPTNIPDLSNLKQFSSLRKVHRITAWILRFVNNARPKSSKLSVPLGATEISSAQTYWIRATQQRHYKEEVADLSKGKELDKSSTVRSTNPFLDKQGLLRLKGRLQFSNVSENEKQPWLLPSKDSYTELVVRDAHDKVLHAGVDATLAQVRESFWIVKGRQSIKTTIRECCICKRYSARPGSEEMAPLPPDRILEAPPFATTGLDFAGPLITKDSEEKHYILLFTCGVTRALHIELVNSMSTENFILAFRRFISRRGLCNTIYSDNAKTFKRADKELSKIWKCISHPSVKNMFANYGILWKYSVEKGPWWGGFWERQVRTIKTSLKKVIGRSTLCVKELETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGS5</accession>
    <name>A0AAV6VGS5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000076">
        <property type="protein sequence ID" value="KAG8195927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGS5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="11184" checksum="DD7F6B7E8FF15376" modified="2024-11-27" version="1">MKAATHHNGSGVSNNIQITNIHPKPTSKPFEKVKFHKRKPLPTTQRVMKPTEDQLSEQFTDRAIRDDMMRSGVPNEEVSRSAYTPKLGYQRRFPKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VH44</accession>
    <name>A0AAV6VH44_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_028963</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JAFNEN010000075">
        <property type="protein sequence ID" value="KAG8195989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VH44"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8195989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="333" mass="38295" checksum="52C9CC2F83FB0ED0" modified="2024-11-27" version="1">MKYMIPTTTRRSSLYIILFVLFSSCSILFHFIQLFSVNSRYLKPWHYPNASNWDNSKRVIQGSLFLPPVPSCSLDSGIRLVVIVCSAPQNFASRQAIRSTWGKDSIWTKSAKVFFVIGRTSQNVTDMFISMEKVEYGDVIHYNLVDSYYNLTLKSVSALKWATTRCPNAKYVMKTDDDMFVNIPLLQKSVLRFKLGNVVVGKLIVNARPIRNKASKWYVPYETYVDQYYPNYLSGTGYVMSQSAAVLLYNSSLSVPFISLEDVFITGICAKNESVKPIDSTLFTYAKQRKNPCRFLTIATAHRMTPNDLYEMWDLIHNIHFRCVTNFWNSIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIV9</accession>
    <name>A0AAV6VIV9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_028971</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000075">
        <property type="protein sequence ID" value="KAG8195998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIV9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000850">
        <property type="entry name" value="PRKACB isoform 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="48"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8195998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="223" mass="25952" checksum="2DEC9E37FD271AF3" modified="2024-11-27" version="1">MVRYDVTSIGVGKVAFLRKMKIFLEEARKDFEEKWTNPSKNTASLEDFDRIKTLGTGSFGRVMLVQHKTAKDFYAMKILDKQKVCKLKQVEHTLNEKKILQAVSFPFLVKLEYHFKDSSNLYMVLEYVPGGEMFSHLRRMGRFTEPHSRFYAASIVLAFEYLHSLDLIYRDLKPENLLIDNQGYIKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKVNVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJ44</accession>
    <name>A0AAV6VJ44_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJ44"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="157" mass="18190" checksum="CA5F53F0DB008A08" modified="2024-11-27" version="1">MSRFVWAYFCDLETNTWIHLKSRLPPSSNFLVFTKVVPSLFSESSDVRPPRTLMALRHDIYICIVDRPGIRWPRNQLVKTKSSSGLLVYELTLFGWLIDLLSRISSADLQAFDNKRRITFSYLRGLLDGLVFDGPTVSNELLKCENRFILSLSWKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJH8</accession>
    <name>A0AAV6VJH8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_007807</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJH8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8196067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="199" mass="22647" checksum="B7BEC19BC5AE466B" modified="2024-11-27" version="1">MVNKCSVPNCRGNYKNGPKVTVFRFPKGELLRKWLVAIRRNDFKPTSNSRVCELHFTKDDLEYVTEAYDERRGCLISVQLPAPRLRKTAVPSQLDGCPSYLSTTVTYREDPNSRKERLDNEQVAAAIAESLKTCTDYEKKHSFSSFNELLNVLKTADISDFWKMVTENQGNLLKVVLNVRGLIGGRIKIKVEENIGLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKD0</accession>
    <name>A0AAV6VKD0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000059">
        <property type="protein sequence ID" value="KAG8197092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKD0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8197092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="346" mass="39077" checksum="5912BDE8D694BE94" modified="2024-11-27" version="1">MDRASKALRRSSVRLKSLGAGHSDLNMVISELKDLKNATKAFMTAQNSASQDMVKWATCDENRAIQDIMSQLGELNCMWTDVQKDFIEHLRTFKNHFELILEGERQLDLAQNTLVSCEQTEQRIRKELKRASKKATEEEINNLEIKLSQAERAKYLAQLEVVELAHKNEAIKVVRLKDGLLKLSEAYVELANKCAIIFEAQREVSHYLPDVHSRDMNELKYTGSGACKQAVAKARDRVQQYKRHNYRLVPSSSIIEDPPPPYTPGFYNPATGRPYNEAMDNRINSGQAPTIQRQRAVATVTISPSCPPYPSYSPPHYNAQAESGPLRPDDLDYEEELSGAMGATHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLE8</accession>
    <name>A0AAV6VLE8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable imidazolonepropionase</fullName>
            <ecNumber evidence="5">3.5.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_007250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000054">
        <property type="protein sequence ID" value="KAG8197512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLE8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01296">
        <property type="entry name" value="Imidazolone-5PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000007">
        <property type="entry name" value="Imidazolonepropionase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752:SF1">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="87"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8197512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="441" mass="47979" checksum="B0A3DBD4C4A1C0D2" modified="2024-11-27" version="1">MSIVPSFKLLIHSAQQIVQVVKNGEKFVVGKALSNVAVLKQSDASSGLSIIVSSDGFIEDFGSDEEISEKYRVNDFQNKIDATGKCILPGLVDAHTHPVWAGDRVKEFSMKLSGFTYMDIHKVGGGIYYTVDQTTKASEDDLLRLLKARLSEMLKCGTTLVEAKSGYGLETESEMKMLRVLERAKRETDIEISSTFCGAHAVPKHMTSQEATKAVLNEQLPALQKLMKSGEISVDNIDVFCEKGVFDLDQSRSILEAGQKMGLQINFHGDELHPMEAAKMGAYLNAHSISHLEEISDQGIVAMAESGTAAVILPTTAYMLKLTPPPVRKMIESGVVVALGTDFNPNAFCYSMPLVMHLACVTCGMSMEEALNASTINAAASLGKSATHGSIEKGKQADFLIINAERWEHLIYQMAAQGSLINNVIKKGNVVYENANPKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLH9</accession>
    <name>A0AAV6VLH9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000068">
        <property type="protein sequence ID" value="KAG8196531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLH9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="8627" checksum="4D4AC23E42FB98C6" modified="2024-11-27" version="1">MDAVVKAGIISEKSGDFGLCGPDGLFAVTGKGATPNTSFNQNTLPPLISSSVLVVGLQMEISSAPLIPSELVDLTPRPTPPEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM14</accession>
    <name>A0AAV6VM14_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000059">
        <property type="protein sequence ID" value="KAG8197105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM14"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="95" mass="10249" checksum="06131CCC4A7C8739" modified="2024-11-27" version="1">MESKNHRQRPQASASMRPSISNSDHLVASSDLAIRHLTAPGLNGVLQDHNSINFKLIKTGRSLANVFGLTLSGRSLALDCHSGGAGHVMRLWHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM40</accession>
    <name>A0AAV6VM40_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM40"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="139" mass="15996" checksum="962DF593AA2F4060" modified="2024-11-27" version="1">MDLDEILHEVGANGKYQTLMLWFVFLPAHLTFGCHAFSQLFMTWTPDHWCQIPELAAANLSEHLIRHLTIPPESTGTGYSRCTMYRLDYSIRTDHNTIILKEPNTNWTNVTCTSGWIYNTSGNWDRDTAVTKVCLLFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMK7</accession>
    <name>A0AAV6VMK7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMK7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="145" mass="16804" checksum="B5E709D5FF57CAE7" modified="2024-11-27" version="1">MDLDEILHDVGEFGKYQKLMLWFVLLPSHLPYGTHYYSQIFMSLTPHHWCQGTSPNTSVNVTYRPLTMWSRNEDKVKNPTISECYVGNWTKLQPDNLTGGVACKNGYEYDRTELYEDESIVTTVEFENDVQLISIALEDASQRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VML3</accession>
    <name>A0AAV6VML3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_020316</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000047">
        <property type="protein sequence ID" value="KAG8197940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VML3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="10">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8197940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="191" mass="21287" checksum="F476AEE7758751AF" modified="2024-11-27" version="1">MRTIYQSTEHLQLTGTVFVGKVILKCSIRDSSFLVSLIYNMLLITICTVYAVKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSFEVQITTLCVSTSLSAYVALFCLFSPKVYIIIFHPDKNVRKLTMNSATYKRAPTSSTTCGPSLNQGNGKGTAVEQVKLSVHMTPSREQTTETDKDSLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNY3</accession>
    <name>A0AAV6VNY3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNY3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8451" checksum="22CFE1F0CD0B678D" modified="2024-11-27" version="1">MVTDGWLLRVAKRGGRPEWGQLGCRHESCIVMGEVADLKVISAPNRNANIWSLVSQESSHSHGKVEVLGPHRNHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPD8</accession>
    <name>A0AAV6VPD8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000045">
        <property type="protein sequence ID" value="KAG8198036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPD8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="9370" checksum="E998EC2A03B92A3B" modified="2024-11-27" version="1">MIHRTIIDMSYPLHKKGPYFKLSFNKAPRAIVMPQSSRKRNIPETGRENARRSRKDEKEFGKNWRNNITQTRKEKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQ08</accession>
    <name>A0AAV6VQ08_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQ08"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="10818" checksum="0E6FA6485E214516" modified="2024-11-27" version="1">MKAEFEGESAQEMAHSGVVALLERSESRIDLLGAHSELFSRPVRRACAPSFSGRVPIGGWPRCQNPSRKRICVLSLRERYLYVHVVGIKCAGYVKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VR45</accession>
    <name>A0AAV6VR45_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_026434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VR45"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8198531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="333" mass="37736" checksum="7B33784DCA34C493" modified="2024-11-27" version="1">MMALTPQREHRLLVVDHTKSVALVPMQTSNVDVNLKKMVFSRHMDNLPRNYHPADSNVPVAWRQREMTLNNPYVRRPSSPSMTSSSSDDREEVPIVRHHYRPLSRHSNVDRREQQLDHYATVRNERFSSARSDRMDNYTPHRTIPPAENYFYRTSGTLRSTRSVPSLAFAAAMEAPDPCPVHGGNHTLARRHGSLFDIRSPPVGGPLSLSGLDKKNFYGSKHSMVNGYHPPPFQFHPDMPQYLPPPPMINPMMRPPPHHPMPLLMDQISLRDPFNKAMAFQHNGASGYPTKEPVDPYRVEQVCCKGHLIVLWIILGVVTVGVILGIIMGVTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSU6</accession>
    <name>A0AAV6VSU6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Orn/DAP/Arg decarboxylase 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_015101</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000034">
        <property type="protein sequence ID" value="KAG8198887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSU6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="8">
        <location>
            <begin position="54"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8198887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="447" mass="50222" checksum="72E0B5B4746757B4" modified="2024-11-27" version="1">MDSVHSKAELYGDFYRELVKKYNGEKFETLLDYLRNVIAGLGADQSFYTIDFADVVLKVQLWRRNMPNIQTFYAVKTNSDPLLLRLLVMLGFSFDCASQGEIELVMQAGASPNNIIFAHVIKTPGALRYSASVGVDLMTFDCEEELVKIQTYFPAARLLLRIAPVNVKCSFDLSDKFGCDAEDAEHILKQAKNLKLDVIGVSFHVGGLCKDPDSYAATIRSAAEVFQVAHKMGFKFRILDIGGGFSGKKGTEDLFDEMTQTIWSVVRENFDEKEIEIIAEPGTFFVGSAATLTTAICGKKKTHKKTGATEDGIERIYYINDSIYGSFFHGVEEYGMRPKPMLEESVLTQRPVYKSRLWGQSCCGEDLLLKVCLLADMEDGEFIMWENMGAYSRVLCSSFCAIPIPATKHIFINNDRLSAEWLNNFEEVTNFLSEQCSLVDAEKHFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT58</accession>
    <name>A0AAV6VT58_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000029">
        <property type="protein sequence ID" value="KAG8199265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT58"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="62012" checksum="1321ADD8DA20F42F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT91</accession>
    <name>A0AAV6VT91_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_011777</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000028">
        <property type="protein sequence ID" value="KAG8199310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT91"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12479">
        <property type="entry name" value="RRM2_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="178"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8199310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="252" mass="27904" checksum="71882EC8DA4CD8AE" modified="2024-11-27" version="1">MMDIRPNNSIYVSNLNEKVKKDELRKSLYYIFSQFGEIADVVALKTQKMRGQAFIAFKDINCSTNALRCMQGFPFYDKPMKIQYAKSDSNAIAKQKGTFVERGVHGKPTSETGEVKKPKKKPAKDKTSNQPPIQPGLLPGIASGSMLQSLVTNAISSHPSVAAAAQQSGRLVEQPPNQILFLTNLPSETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVLSAAAKEALQGFKITPTNAMKITFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VW64</accession>
    <name>A0AAV6VW64_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000021">
        <property type="protein sequence ID" value="KAG8200012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VW64"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12636" checksum="7C5042BE045ABF13" modified="2024-11-27" version="1">MNVGENESVLVRVANEGSRIMLLKRGWNWEKILSTPLPMIPLIHPISNEKKKDVNELLTTLFSTEWINDDSLSWYRNIVSNEAFPTSSENDECVKEIECDCLEDDCAIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXJ7</accession>
    <name>A0AAV6VXJ7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXJ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="10396" checksum="FE0E93E34BCD8569" modified="2024-11-27" version="1">MPTCASSPQIKFFHFDPLKSNLLRPRSLETYVTLQSRKKFLAMSHDYCTPCMTSSDEDGTKARVLKNSLANMRLHHEEFFRRELLSSASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXP9</accession>
    <name>A0AAV6VXP9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-galactosidase</fullName>
            <ecNumber evidence="10">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_020591</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAFNEN010000011">
        <property type="protein sequence ID" value="KAG8200953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXP9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019377">
        <property type="term" value="P:glycolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000070">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF83">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8200953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="393" mass="45008" checksum="7A806DD346D885CD" modified="2024-11-27" version="1">MEQNLSNNFLQLGFKGGGSACTLNNGLALTPPMGWLAWERFKCNTDCENDPDNCISEKLFMRMADVLIKEGYRDAGYLYVNLDDCWMARRRDQKGNLVADPERFPHGIKFLADYMHTKGLRLGIYQNFGLKTCMQYPGIAGHLEKDTKSFADWKVDMVKLDGCFTDPSILNNGYINVGKFLNKTQRPMLYSCSWPYYQLISGKEPHYKLISTHCNMWRNFHDIADSWEVIEGTIKFMGDNQEVLSQHIGPGHWNDPDMLMIGNFHLSHGEARIQMSVWSILPAPLLMSNDLRSIDKESKKILLNKVAISINQDHLGLPGKRVLEIPQLEVWTRPILPVNKKKETSFAVLFINKSKKSKKVVKLVGILQHKSQFWLSWATLGFMAPNLITQELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXX1</accession>
    <name>A0AAV6VXX1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">medium-chain acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="5">1.3.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_028573</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a medium-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:14477"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83723"/>
            <dbReference type="ChEBI" id="CHEBI:83726"/>
            <dbReference type="EC" id="1.3.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.7" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000016">
        <property type="protein sequence ID" value="KAG8200396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXX1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070991">
        <property type="term" value="F:medium-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000010">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000007">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="17">
        <location>
            <begin position="42"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="157"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="15">
        <location>
            <begin position="267"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8200396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="424" mass="46088" checksum="2E39B720C0B46F60" modified="2024-11-27" version="1">MIPISKVLRPSAFLRIPMRLLSTVPEPSQAAKANGGMHFELSPEQKEMQEMARKFAREEILPHAAELDKTGKYPTEILKKAWELGLVNATVPTKYGGSGLSLFDACLTAEEMAYACTGVNTAIGANELAQAPLLLGGNEAQKTEYLGRVTKECLMCAYCVTEPGTGSDVAGIKTKAEKKGDSYVINGQKMWITNGGVANWYFVLARTNPDPKCPASKAFTGFIVDADTQGVTPGRKEWNMGQRASNTCGVTFEDVVVPAANVLTAEGAGFKIAMGAFDKTRPPVAASATGLAQRALDEATKYSFERKTFGQRIAEHQAIQFLLADMAIGIETSRMAWMRSAWQTDNGQRNTYFASIAKALAGDVANKCAADAVQIFGGNGFNSEYPVEKLMRDAKIFQIYEGTAQIQRIIIAREHFNSFKQQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VY45</accession>
    <name>A0AAV6VY45_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000009">
        <property type="protein sequence ID" value="KAG8201036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VY45"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="131" mass="14989" checksum="EBB9A1925A33CBEB" modified="2024-11-27" version="1">MGGFERSGLEIHGLLEVGKSRQIIARFRWALMRFTYRNVTETSLIEYSLWTWPLFSDATEAINLLKPPSPPNGQNNNKITRRDHGKEIAAWRTLEQQHGWDVETGGASRDTWAAGSWKCRQNNSQDFVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYV0</accession>
    <name>A0AAV6VYV0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">DNA repair protein REV1</fullName>
            <ecNumber evidence="13">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_027284</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="13"/>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYV0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012112">
        <property type="entry name" value="REV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036573">
        <property type="entry name" value="REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 13" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="97"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="17">
        <location>
            <begin position="351"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="217"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="951"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="955"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR036573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8201802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1110" mass="124719" checksum="A4AE450B3879CD48" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDX2</accession>
    <name>A0AAV6TDX2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006321">
        <property type="protein sequence ID" value="KAG8156115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDX2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8156115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="53291" checksum="6A9B95B44A71AC96" modified="2024-11-27" version="1" fragment="single">QSVEKVRATIEWGLPPLDSSTRRGVLAPLTPALYCLCCGPHVGYSCRRIASASQDHLLVELERARASSLPPPGPPGHLDAAVGEDAPLPTTCSIAVGDDFQALWTPPALCGRCLGDDSPPRIILLVDDSERGLQSLASRAKAAADALEISPVSPISPPLNATDDSSPRPRHSWSSRDSGRGSSAPPSLHDELSASGTSHLLSSTINSRRSSRSSLKRVSFGADVVIHGPPSPLGPPPPPVHSARRRVIVFGLSELSSASSICDALLGLPSCPPGPLDVVRFFYGRDGSRNCILSADSLICDFLDGFPRISIDHLRVRVRRFIFIGRCFNCHHLDHLAKDCSLPPACGICGGTHRSSGCCDPPRCLLCPSNNAHRSDSPTCPTLLAYKKSKLAAHVRSTSLRQGPPSPPVRRSVTVRLPLDRILPGSSPGPRPPGHTRADFPMAPASTSMVTLPAPPPASQERLPLMYYSDGSSCRSSQDDDADPSCSDEDVYDQYDLAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THE3</accession>
    <name>A0AAV6THE3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004184">
        <property type="protein sequence ID" value="KAG8171300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THE3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="13915" checksum="5CCAB85970F5D749" modified="2024-11-27" version="1">MIPPQDFEGPPPLPLRDFNSWEPPLFKFFATFPHGKLFAIGLTEVLALGGFNHPIKVALPSKPHSQRGRIRINPGSYGPSHPLWQHPGQGACESPLRDAQILNATFPTPLRAGIRPGFSRFHSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THI3</accession>
    <name>A0AAV6THI3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004295">
        <property type="protein sequence ID" value="KAG8171206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THI3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="4"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="172" mass="19881" checksum="04AD4B1B8D84DE83" modified="2024-11-27" version="1">MKPIPDYPFQRVPSDLFEFNKKPYIVIADSYSGFYDFQKLQHPTTRDCIEVLKRWFSVHGVPEVFESDNGSQYASKMFNEFLESWGIQKSQSSPYHPQSNGLAERAVEASKVLLKRCQKDNSDIALALLNVRNTPREAGLMSINQRLMSRTTRSLRAIYDKFSQAKSCRRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THN0</accession>
    <name>A0AAV6THN0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004307">
        <property type="protein sequence ID" value="KAG8171193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THN0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="35" mass="4035" checksum="322E77723494D428" modified="2024-11-27" version="1" fragment="single">ALVLLSHGFTEHCMMYDELAKALVQRGFFVFAHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THV3</accession>
    <name>A0AAV6THV3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004554">
        <property type="protein sequence ID" value="KAG8171031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THV3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="162" mass="16923" checksum="3734E472E890C851" modified="2024-11-27" version="1">MEPFPALVPKVHFSICYYHQDLHPGAAPGGLTPAPSTHGHRDPPTTAGPYPAAPILPDGVLALSEPLGKPPPEFPLASPLAPGYFPHLSGPNVCGSQNPPLPKWNAGGFPGAPAREGKGIPNAAHLRPAPYFHFAARGYSKTHCSRTCLNSLWAVFQDGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TI58</accession>
    <name>A0AAV6TI58_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_022864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003866">
        <property type="protein sequence ID" value="KAG8171533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TI58"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8171533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="120" mass="14463" checksum="DC16A350D082ADF0" modified="2024-11-27" version="1">MLYVCQICSKRFEDVQQLKKHSLIHTKNKHLCQMCFKSFKTRRQLIAHSVTHKTKTEAPFACQVCSKQYPTEKQLQKHFRTHTDMVTHKCQECDKVFANRANLRKHMGYHTRHHVLQRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIE3</accession>
    <name>A0AAV6TIE3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004289">
        <property type="protein sequence ID" value="KAG8171215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIE3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11800" checksum="DF595CBADFEA42A6" modified="2024-11-27" version="1" fragment="single">LVVVAVLRLIYGAAVSVLLGFSWWITVSASLACFPHVSASLRVVRPPCRAAPSRKLFLWEYGAYCDRSIGLRVGVSLNAVRVANSTRLSSFSTLVVSSPRCNMQRGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLL7</accession>
    <name>A0AAV6TLL7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_018817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002677">
        <property type="protein sequence ID" value="KAG8172469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLL7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043933231" description="MD-2-related lipid-recognition domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="2">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8172469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="8769" checksum="06252F5C3CEF7C6B" modified="2024-11-27" version="1">MNALLVFAMLACFSLSTASPFKDCNPKGKEAKVKSVDISGCDNNAARCELQQGSDITVSIKFTPKKAVNNLKVCMGMYLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLW1</accession>
    <name>A0AAV6TLW1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_019127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002296">
        <property type="protein sequence ID" value="KAG8172864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLW1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_eL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_eL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8172864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11271" checksum="1DB53C8CB23A12DA" modified="2024-11-27" version="1">MESINSRLALVMKSGKSVLGQKQTLKALRQGKSKLVIIANNTPPLKKSEIEYYAMLAKTGVHHYSGSNIELGTACGKYFRVCALSITDPGDSDIIRTMPTEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TN55</accession>
    <name>A0AAV6TN55_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002153">
        <property type="protein sequence ID" value="KAG8173009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TN55"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8525" checksum="9453CD1472E949CB" modified="2024-11-27" version="1">MMQSKLKFLLSQGIIHPSKSPWSSPLHVVPDSTVRPVGDYRRLNSVTEFDSYLIFIVFDFLTTVVYAIRSTDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNQ7</accession>
    <name>A0AAV6TNQ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Shugoshin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001955">
        <property type="protein sequence ID" value="KAG8173246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNQ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22511" checksum="A333D1699914DB67" modified="2024-11-27" version="1">MSMMLQKKLHLLQQRNQKVVPIIKSPEDEVKEVENTAIEAMNEDETSNASIAKESTQDSSTNNDPIAPEKENITEAKATEEKQKLEAGQGPAVRADYPNPAKARRRSSAPDQETEKRTRSPVRNIRKRRSYSSSDSSSPEVPVLETRSPYRDTSRVPLGDPANTHQSEARVLLEEGPRDRLLHHGDRDDPHLRGEDPSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNX8</accession>
    <name>A0AAV6TNX8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger MYM-type protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_003636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001879">
        <property type="protein sequence ID" value="KAG8173321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNX8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF23">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="2">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="417"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8173321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="56745" checksum="6F20E051E9365B57" modified="2024-11-27" version="1">MSRKVLEVIIQQVHQAKYFGLIVDSTPDISHIDQLAIVLRYVDTDGDAVERFLTFHAIHNHTSSHLHDVIVEYLKSLNIDLKYCRGQSYDNASNMSGKYSGLQARLKDNHLIEYVPCSAHSLNLVGTNAAECCSSAVSFFGIVQTLYNFFSGSTHRWELLKEQMKNETRPITLKSTSTTRWSANADAVKALKKNFSAIGNVLCAISNNPEENLSTRHDAKSLFGSIKTFEFALMLIIWDAILQRINKSNISLQKVNCEISTIISLYESLVAFIQKVREEFDMYEVEAAKLAFTKEYTSKRKRNTPKSKHLDESSSTGVSLSDREKFLYETHNVLCDAIISELNKRKKAYSSLDTRFGFLTSKNMGTYEIQKAAKNFQEIYTDDIEEFPEEYLQFSNFNLGNITPSEKLKGLKSLGIEHTFPNVSTALQIMLSIPISNCSSERSFSVLKRIKNRLRSSISLNNLSYLSLLAIESDLTEVINFDDVIKDFVSAKTRKMPFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPP1</accession>
    <name>A0AAV6TPP1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001790">
        <property type="protein sequence ID" value="KAG8173416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPP1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9603" checksum="B08B0F04557FFA27" modified="2024-11-27" version="1">MKKPIVLNYLTGEGLVIEPTVCDGIYEAKFCIKLLGCMKAQLEREDFVLQEITEIPVNMCAALVMKGSTILVFTHALVMAAMVLVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRL2</accession>
    <name>A0AAV6TRL2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transferrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_015522</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transferrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001249">
        <property type="protein sequence ID" value="KAG8174344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRL2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:iron ion transport"/>
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    <keyword evidence="4 8" id="KW-1015">Disulfide bond</keyword>
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            <end position="623"/>
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            <end position="348"/>
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            <position position="68"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
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            <position position="96"/>
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        <location>
            <position position="122"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:17544"/>
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            <position position="126"/>
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            <label>1</label>
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        <ligand>
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            <label>1</label>
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        <ligand>
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            <label>1</label>
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        </location>
        <ligand>
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            <label>1</label>
        </ligand>
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        <ligand>
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        <ligand>
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        <ligand>
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        <ligand>
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        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
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        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
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            <end position="210"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="244"/>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="623" mass="68180" checksum="288D2E29F780D13F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="3">DUF4806 domain-containing protein</fullName>
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        <lineage>
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            <authorList>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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    <name>A0AAV6TTG7_9ARAC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Araneomorphae</taxon>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
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                <person name="De Corte Z."/>
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                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8486" checksum="3CC56CB8ABDA497F" modified="2024-11-27" version="1">MEFLENEMKTAFNLLTPQLKIDVFYIAEPGHVLEEDRLLPLRKDPSNVSHVKVDDGVSVNTSSSLQLTDDFPVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTG8</accession>
    <name>A0AAV6TTG8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">JTE90_002481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
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            <taxon>Araneomorphae</taxon>
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            <taxon>Araneoidea</taxon>
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            <taxon>Erigoninae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
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            <authorList>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8174959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="397" mass="45276" checksum="3D41E1252860E544" modified="2024-11-27" version="1">MWQLWTPPRIIGSPICCKSWPTCRTLPAKEIASTTSRWTKNTFIKGKGLEHLKFCLHAVLGEVPFDSRQLDRTWDSIGRRLRRDPSRSLSNSNVCLLFKLHNMFLVKKGFTFGNSLVAEDEHHVIQTSNAAMMCFVLPENSLIPAQERMRRHLPENYQLFYDRYVLPPHGTYLVPKNTRYVLVAVQKTIFALDVISSEYLFQGATPFDACKRYCTQQAEYNVPPPTPCRSPKPPPSTESMMMPPPPCPPKKRKSPWGSYKIPKKNCQPTPEPTPTPVVPEPTLPTTILMQPEIVPLPEKASHQDLQFVPEMDFNSLEMVEEEASEKSVADYVNNFFSNISFGDDPFQKSSFPDLDLSFLEQPSNLILNPAPSKTIFGNPKDFPPVQFFMKSQNKRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTZ0</accession>
    <name>A0AAV6TTZ0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Arachnida</taxon>
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            <taxon>Araneomorphae</taxon>
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            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001068">
        <property type="protein sequence ID" value="KAG8175112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTZ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043809441" evidence="1">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="85" mass="9635" checksum="7E06C79517418D7A" modified="2024-11-27" version="1">MGFWTIKSLWCLPVNSTVAIRFPDAWISHLCDSPLEENGTRPIRQCLTSLLQPWAWSICGSDSAFWKPSQVSLQLNIFTCKGGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUH4</accession>
    <name>A0AAV6TUH4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_021360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000959">
        <property type="protein sequence ID" value="KAG8175710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUH4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015889">
        <property type="term" value="P:cobalamin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002157">
        <property type="entry name" value="Cbl-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051588">
        <property type="entry name" value="Cobalamin_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559:SF18">
        <property type="entry name" value="TRANSCOBALAMIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559">
        <property type="entry name" value="TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01122">
        <property type="entry name" value="Cobalamin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043876876" evidence="9">
        <location>
            <begin position="24"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="458"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8175710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="615" mass="69839" checksum="C4E188101798EF7A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUQ4</accession>
    <name>A0AAV6TUQ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_014833</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPII-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000997">
        <property type="protein sequence ID" value="KAG8175454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUQ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000005">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1670:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="12">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="13">
        <location>
            <begin position="131"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="15">
        <location>
            <begin position="429"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="14">
        <location>
            <begin position="546"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8175454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="647" mass="72500" checksum="5003BE2284372099" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVQ1</accession>
    <name>A0AAV6TVQ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_004380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001002">
        <property type="protein sequence ID" value="KAG8175441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVQ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="50"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8175441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="165" mass="18094" checksum="B9EF18C9655195CF" modified="2024-11-27" version="1">MDDTNNYMKPYPNESIFDEYETYPDFTQIAWVRTTYVLAYVLVIGLAVSGNALVCWTVASRRRMRTAVNLYIANLAACDLAVGAFVAPVKLAELAAPASWGLLSDSVCTAAVYLQTCVVFASVLTLVAICIERLVMTHICATILTMLPNIVLFQRSLNEVKLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXG3</accession>
    <name>A0AAV6TXG3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000916">
        <property type="protein sequence ID" value="KAG8176156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXG3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16019" checksum="245511E0521DACED" modified="2024-11-27" version="1">MVSGKSLGSKTSIHVALEGMPVGSDYGDVYVSLINRHFSVTDVASRDRVLCNDSAMPLIGHAELGSAIGSQKGSKAPGPDGINPTIVKLLYSKIPDLFLNLFNSLLRFSYFPGVWKFANVIFFGKRGKPVELAQSYRPVCLLQSLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZS3</accession>
    <name>A0AAV6TZS3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000822">
        <property type="protein sequence ID" value="KAG8177078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZS3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37557">
        <property type="entry name" value="115 KDA PROTEIN IN TYPE-1 RETROTRANSPOSABLE ELEMENT R1DM-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37557:SF4">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="454" mass="51724" checksum="20A30A852FE6B5BF" modified="2024-11-27" version="1">MDDLVLVADSPLGLQNTFQKIQPVLEATGLKINTKKSITFQWLKDGKKKMIFDHRPFIRVRGQPLQALRITDQFKYLGIFFTPRGKTPAKTDLREKLMTLQGAPLKPQQKLFLLVHHLLPGFQHTLTFGKISCGFLKKLDIVIRSLVRNILKLPKDTPTAFFHASIKDGGLGVPSMRWNIPVLAHKRGNFNRMIYDGEVELRSTTQAATRWRRLLYNSCDGSGLREASAVPQCHRWLSDGTSLMSGRSFISAVQVRSNTLFSRARAARGRPEKQQAHQCSRGCPQPETLNHILQVCFATHKQRIKRHNNIVDYLHRGLLQRGFTVHTEPRFETPGILKPDLVVYSEEEVSVIDIQVVNDQYSLEVANKNKIQKYEEPLRPHLQGLRSKYSVIGLTINWRGILCRTSVEELLKRRMISKRDLKILKVKTLEGNARIHGCHQDMTSHVSGLKKGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U028</accession>
    <name>A0AAV6U028_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-protein coupled receptors family 2 profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_003628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000784">
        <property type="protein sequence ID" value="KAG8177366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U028"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043865657" description="G-protein coupled receptors family 2 profile 1 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8177366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9151" checksum="9AEB04CA74360D5E" modified="2024-11-27" version="1">MNFISFFSILLDSSCSAAWDSFICWPPLPAGETMSKPCPQMNTRGVVIGDAAHPGMFAVRTCAENGSWVENRTNFSLCMTNIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0T8</accession>
    <name>A0AAV6U0T8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000775">
        <property type="protein sequence ID" value="KAG8177523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0T8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="10557" checksum="F4AC508492E30EEA" modified="2024-11-27" version="1">MEPDALNDFKKLCEGCALNVRVKHCADKVVFKTPTLILTNDPLEICSDPAFKNIRVKHMRYKRAPFLKEVVKKPYPMAFFDILDYYDIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1N2</accession>
    <name>A0AAV6U1N2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000731">
        <property type="protein sequence ID" value="KAG8177974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1N2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36696">
        <property type="entry name" value="AGAP012002-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36696:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="273" mass="31544" checksum="4CE2A83EA3BDCEFD" modified="2024-11-27" version="1">MATENVTAEEKLDMVDENEEKEVVADAQEPGNEGQAEKEVENERDDMATAKREEKPGSSEMKEADDADRDKVPVKWIRSKRPTSVMKTKLLVKDVVKFIEEMKKKITQEDLNLRVWPHLASCRFELPIDLTRLEDLTPLKYVSQYCRVTDSRRAVYAAKYERHLQQSEGKSVLTSDLREVYEKIYQEPKLADEMLHLRRLLDMDLNEELDVELFTAVSCVMERVIVKSKGLEISQENTKNAFEETDFCALRAKLNGLQVSPSLRSLLEFIRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U231</accession>
    <name>A0AAV6U231_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000713">
        <property type="protein sequence ID" value="KAG8178154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U231"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20191" checksum="8F4BA8C58BF6D201" modified="2024-11-27" version="1">MRSSEVNYTGKEQICVKINGRNCVMEVDSGSEYSIISESTFNRLFVSKPKLHRDLVHLQDFQKRENENVNEKKYWKKMESLGDSVSVPLVKIDYQMCAYPPPPPAPPCPPPSTRWSRTPLGSGSRFPRDRLVLGEGAFGQVVQAEARDEDNTNRVVAVKMLKDVKNGRICDAPLPNLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U247</accession>
    <name>A0AAV6U247_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_011652</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000725">
        <property type="protein sequence ID" value="KAG8178022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U247"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
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</entry>
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                <person name="De Corte Z."/>
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                <person name="Kostlbacher S."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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</entry>
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                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">W744_W776</strain>
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    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG8178457.1"/>
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        <property type="entry name" value="Spidroin_repeat"/>
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    </dbReference>
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        </location>
    </feature>
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            <begin position="36"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8178457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1300" mass="132605" checksum="256071BC370973BA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3T4</accession>
    <name>A0AAV6U3T4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RanBP-type and C3HC4-type zinc finger-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_017603</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000660">
        <property type="protein sequence ID" value="KAG8178905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071797">
        <property type="term" value="C:LUBAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20345">
        <property type="entry name" value="BRcat_RBR_HOIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16633">
        <property type="entry name" value="mRING-HC-C3HC3D_RBR_HOIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20358">
        <property type="entry name" value="Rcat_RBR_HOIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000137">
        <property type="entry name" value="RanBP-type and C3HC4-type zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047558">
        <property type="entry name" value="BRcat_RBR_HOIL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047559">
        <property type="entry name" value="HOIL1_RBR_mRING-HC-C3HC3D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047557">
        <property type="entry name" value="Rcat_RBR_HOIL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="999"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="1182"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="1186"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="449"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="762"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="856"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1081"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="866"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1090"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1142"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8178905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1414" mass="158424" checksum="8FBE94C107839D3E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U498</accession>
    <name>A0AAV6U498_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_026293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000703">
        <property type="protein sequence ID" value="KAG8178325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U498"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000962">
        <property type="entry name" value="RBMX2 ortholog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8178325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="425" mass="49083" checksum="CA67C532F02C0569" modified="2024-11-27" version="1">MNPLTNVKNIAKLNELELAKGTVDKKSWHDMYKDSAWIFIGGLSYGLTEGDVLSVFSQFGEIVNINLIRDTKTGKIKGYCFLCYGNQKSTILAVDNLNGIKLCGRTIRVDHVSNYKPPKDRETDDDLTKQLKNEGCAPKPIKVENAHSSNASEPTSSEKKKSKKAKKEKKKHKKKNKKHESRKETENFENVKVKEEKTDPGYDKNELLDGRKSRTRNETASDSSDSESSSSDSDVSNSSNQQLSRQKASHHIKHKNTSEQSHREKYDSHISSKSGSYYDRVAYGKPESIQNERSASSRDGYYKSNRKKRYQDAAESSPRSRSPDKDRKRKYYDEDEINERSDSHKKKHAAEYKTSSRHQRHDSSSSSGSVSDQEQSRFQDKRHEKYGKGHFDEEKYSKSRKKYDDSQQRDYDRYSEKSKHERDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U506</accession>
    <name>A0AAV6U506_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000615">
        <property type="protein sequence ID" value="KAG8179607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U506"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="264" mass="30520" checksum="F8DF24E949E9E636" modified="2024-11-27" version="1">MWVGEACSQEEDITSVTVVDALLQIFSRMGFPKVLQLDQGSSFTSALSTTFLEKFGIKVVHSSVYHPQSNPIERFHRTVKRVLKVLCLESGSDWEQAIYPALFVLRTVTHESTGFTPAELVHGKNLRTSLTLLYEKWLDVEETEGEPVTEYVFSLINRMKRCQELAISKMEECQQKNKTWYDKRAVKREFRIRYLVLIFAIFKSNKLSPHWTGPGTILRKLSETNYVVQLPGEKATSKVYHVNMLKPYYKRPEEINYLISDLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U597</accession>
    <name>A0AAV6U597_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Down syndrome cell adhesion molecule</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_012491</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000655">
        <property type="protein sequence ID" value="KAG8178978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U597"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000104">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF54">
        <property type="entry name" value="FI24025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="32"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="132"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="232"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="332"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="435"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="537"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="707"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="708"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="739"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8178978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="826" mass="91025" checksum="8CA0633647429882" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5T6</accession>
    <name>A0AAV6U5T6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000621">
        <property type="protein sequence ID" value="KAG8179535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5T6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="242" mass="27470" checksum="A8F7FA577D128EEA" modified="2024-11-27" version="1">MELFKPPPEISFTCGNVAENWKRWIQKFNNFMLATEKNEKPDANKIAILLNLLGDEGVKLFNTFKFEKTDTLDEAADYSVVLKKFEDYYAEEEPACEFGEQEESLIRDRVVLGIRNLNLQERLLRETDLSLTKASEFVRAAETSKEQFQSMKGLATSVNAVTINSRKRFQPKDSPAQTTMTARNVVSTIRELSALSTRKSAPSASRRIILLWVADLTTLLAERSKSSILKNTCQMLSCTCHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5V7</accession>
    <name>A0AAV6U5V7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Frizzled-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_014016</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000654">
        <property type="protein sequence ID" value="KAG8179015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5V7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07448">
        <property type="entry name" value="CRD_FZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000008">
        <property type="entry name" value="Frizzled receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041765">
        <property type="entry name" value="FZ4_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF99">
        <property type="entry name" value="FRIZZLED-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043843261" description="Frizzled-4" evidence="17">
        <location>
            <begin position="23"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="18">
        <location>
            <begin position="28"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="19">
        <location>
            <begin position="237"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8179015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="565" mass="64817" checksum="97003FB171DA8790" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U815</accession>
    <name>A0AAV6U815_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">U6 snRNA-associated Sm-like protein LSm5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LSM5</name>
        <name evidence="15" type="ORF">JTE90_020819</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000600">
        <property type="protein sequence ID" value="KAG8179836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U815"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8179836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10007" checksum="E99D2666A689C91F" modified="2024-11-27" version="1">MSATSISSPANLLPLELIDKCIGSKIHIIMKNDKEIVGTLLGFDDFVNMVLEDVTEYETTPEGRRVTRLDQILLNGNNITMMVPGGEMPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U847</accession>
    <name>A0AAV6U847_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_007458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000560">
        <property type="protein sequence ID" value="KAG8180502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U847"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043697789" evidence="3">
        <location>
            <begin position="24"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8180502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="433" mass="48119" checksum="C05A3880A8A0893D" modified="2024-11-27" version="1">MSAVLRLLCCVCCFNTLIALVHATQCDPSRFLCSGMCPPFPEDAAPPTDEAVCSRDPDSDTCVCWLHNPDSQLHTLFQCEARINGSTSKVACYPPSDCFLPDQNVGCLIVLQCQCVLFDQSYQYQKTDSWKRVKAVVHTMKKTADNQDGYPIERMQDIREFSLKHLLFLLGFVVAPLLCWCLLNFFHDGKCRKKPPAPPEAQPMPTSRNSTLDNSSDFDIVQPTSSPRHLASSQSCSIPIPSAPDIDAVLESDSQQEAFLKCESPPPYCESTDRSCPIDCGPPPTYEDALRGSDLNVQQLWQTVFILQYVARGKEKGWGSPKPSALVNDGGLSQTALNEVGSKVVRFGTGNVPQSRERQLAKYFQNILIIYTCFTNCVAQHNIVQGIGTHGKYYCFNSFYTFTDTNRLAFTVDSEVGFQAVRLQIPHMLGTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8F1</accession>
    <name>A0AAV6U8F1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_022794</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000564">
        <property type="protein sequence ID" value="KAG8180449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8F1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF72">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER NCKX30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="19">
        <location>
            <begin position="259"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8180449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="420" mass="45370" checksum="ED6A9A9E65B087DC" modified="2024-11-27" version="1">MNAKRKMSTPMLHAGSKFRSGLLQLMIHTIDPMHDGKLDEKETNLHAMASLRVLLEAQKTNGSAVNTMMKSSASCPACSDCPDCTHGVQHPGMVDSHSFAPTMTPVAEDGGKSPPSNVRVIWTANNSSAGTFMTRSIRSDPGDGPGGVLRAESIGSNGPTNADSSQNVNIIMPISESKSTIHHSNSINSTGSQVVVAPQEAAEAAPAEEEEEEGDKPLDISWPDTWHKRINYVLLAPIIFPLYLTLPDTRRPEKRKYFYVSFLGSILWIAVFSYLMVWWASLVGETAGIPNEVMGLTFLAAGTSIPDLITSVLVARKGFGDMAVSSSVGSNIFDVSVGLPLPWFISTLIFGPVHVSSSGMACSLLLLFLMLLFVIISIAAFKWKMNVGLAMVMFFLYFVFIACSLLLEYGVVSCDDLLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UC57</accession>
    <name>A0AAV6UC57_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cathepsin L</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_022226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000523">
        <property type="protein sequence ID" value="KAG8181288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UC57"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="130"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8181288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38517" checksum="533E846F7F1B3E87" modified="2024-11-27" version="1">MSSYDKVYLVLQILAANNMKFILLLAFFTSCNSMPFTPELDEHWENFKSVFGKIYNSHEEGARRLIWEDRVVAIVLHNLKADVGLVSYRKGLNTYSDLTPEEFSRRLKGYKRSMNVTGGSTWLPPENMELPKTVDWRTKGYVTKVKNQYACGSCWAFSAIGSLEGQHFKKSGKLVSLSEQNLVDCSGPEGNEGCEGGLQEQAFQYIKNNHGIDTEESYPYEGFQDECQFKESGIGANCTGFVSVKGEEALQQAVATIGPISVCICTSEDFYSYKSGIFDPDICYSDPAYLDHAVLVVGYGTANGKDYWIVKNSWGTSWGDQGYIKMVRNKGNKCGIATRASYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEF0</accession>
    <name>A0AAV6UEF0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000489">
        <property type="protein sequence ID" value="KAG8181910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEF0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="102" mass="11794" checksum="BEB6A451AED3698E" modified="2024-11-27" version="1">MVSCEGLDDGRLFRLLKTRYHGCDSNPLLEILAIKESMMTEEILDILASKKHILEDAEVKEMLEIYDDCIRNSDGMPYKRAKLSTKSYSEFQKKFTDLVNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEH8</accession>
    <name>A0AAV6UEH8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000478">
        <property type="protein sequence ID" value="KAG8182143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEH8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="10027" checksum="E0A73CCF0626F973" modified="2024-11-27" version="1">MDLFRTCKSLPNLVPNQPIWEPPQKHKPALEEPSSCLRMTFPSDRIASQPRCRLTGQRPMIVCQQECEKTFFVASLFVKEVRDHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFP7</accession>
    <name>A0AAV6UFP7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DAN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_010562</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000440">
        <property type="protein sequence ID" value="KAG8182931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFP7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051427">
        <property type="term" value="F:hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000049">
        <property type="entry name" value="Glycoprotein hormone alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052680">
        <property type="entry name" value="Glyco_Hormone_Alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31129">
        <property type="entry name" value="GLYCOPROTEIN HORMONE ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31129:SF2">
        <property type="entry name" value="GLYCOPROTEIN HORMONE ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="DAN" evidence="5">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8182931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="126" mass="14174" checksum="EEBC43C720D92072" modified="2024-11-27" version="1">MAKLMKHVAQEKKIKVQLNFFPAGLATPWEHSGCHKVGHSRSIRIPGCVVFDITTNACRGFCSSFSTPSPEWIVRSNHRQSVWSVGQCCNIMETEDVYVEVMCLGGMKELVFKSAKTCSCYHCKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIS2</accession>
    <name>A0AAV6UIS2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor SPF27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_003871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000414">
        <property type="protein sequence ID" value="KAG8183521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIS2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8183521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="212" mass="24488" checksum="BAE0BDFA8672100F" modified="2024-11-27" version="1">MAGEVIVDALPYIDQGYDDPGVKDAVFSMVEEETRRYRPTKNYLEHLSTLNLHAFETEVLKTEFERLQARLPMDVLSMKRYELPQPAAGKMSDLAAWTESVDNSMAQLEHQATRICNLELMSVYGCETWKACNATLVQMVNQTQKQLQDLRKKILEINWQRKNSQNTAGEKLRDLESCWVGLVSKNYEIERACAELEKEITLIEMKTSKYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJI0</accession>
    <name>A0AAV6UJI0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_007691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000369">
        <property type="protein sequence ID" value="KAG8184575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJI0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="2">
        <location>
            <begin position="198"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8184575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="392" mass="44945" checksum="EBB64D8FF4FE0AB5" modified="2024-11-27" version="1">MRPNCKDISEIERLLRVLGVLETDIETGSTFEAELDSNINKMLQGSFRSLFSINCCVRHSSINKFLQISNRTYINALKKRNQHSFLTGNRTFVAYAKVLCKEATPFNPLESSGIQKSIAALQAKKRVPKRKAQISKEDLDQKAGQVVAYSSAEEYDIERLTVALEKKGLYQLLQLPEDADEVIHVSAKYQVGNEPRHIYFFSEGSVVFWNVPDLEQQTVLRFLKPFETNSFDPELVAAEKEDLDYIYSEKGTKFSNGRIILSSEGDTDFYTYTFSNSLALSVKLAMWEAALENYIDSMEWVTENMKKGEEISMSRNQVFKKRGELFALRHVINLSSDLLDTPDFYWDRQDLEVLYQQTCNHLNTAKRTKLSNNTIPHQRYSDGTKLLFASLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJZ5</accession>
    <name>A0AAV6UJZ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohormone-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000413">
        <property type="protein sequence ID" value="KAG8183586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJZ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044011963" description="Prohormone-3" evidence="1">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="21878" checksum="549B2E40ADC47730" modified="2024-11-27" version="1">MAVICVTIFLMAAFIYEASGQYVFPDGVEVGNWGNGEIQTKRGGGAEGLEALLSRDEDYRCYGKTCQHSEECCRGTTCVDIEGASGTCLPTSGRQMSYQSCNDDAECSAGLSCTESGGYYKTCQLDTASIHKKAGFNDECVNSSECDTDHGLCCQILRGHRVTTRRVCHYFLDPKSCIGEFRAGAKELKFVANPFFKARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UK40</accession>
    <name>A0AAV6UK40_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Breast cancer anti-estrogen resistance protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_010136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000411">
        <property type="protein sequence ID" value="KAG8183661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UK40"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10337">
        <property type="entry name" value="SH2_BCAR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000013">
        <property type="entry name" value="SH2 domain-containing protein 3C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000015">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051853">
        <property type="entry name" value="SH2-Ras-GEF_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044102">
        <property type="entry name" value="SH2_SHEP1/BCAR3/NSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14247">
        <property type="entry name" value="BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14247:SF8">
        <property type="entry name" value="RAS-GEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="163"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="6">
        <location>
            <begin position="516"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8183661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="90548" checksum="B3A35210B8FB1959" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULA5</accession>
    <name>A0AAV6ULA5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_026352</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000373">
        <property type="protein sequence ID" value="KAG8184433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULA5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000001">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000078">
        <property type="entry name" value="Putative Inward rectifier potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="15">
        <location>
            <begin position="57"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="16">
        <location>
            <begin position="204"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="456"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8184433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="496" mass="55054" checksum="FFD873FE4B38FB2F" modified="2024-11-27" version="1">MSSASGTTTAIEMQSGHRPLYRSRSTGSHHSLKSTGTADTSGVMRLTRSTALRKRVVLKNGTVNLQKAHVSKRKQAFLQDIFTTLVDIQWRYNLMVFALGFLLSWIGFALIWWLICLSHGDFQHVGDDEWTPCVSEVHDFATAFLFSVETQHTIGYGSRCTSEECPEAIFIMCVQSITGVMIQCFMAGIVFAKLSRPKNRSQTLLFSRYACVCLRDRRLCFMFRVGDMRKSHIIGATVSALVIRRKTTAEGEVIPYYHTGLDVRFDDGSDSVFLIWPATIVHVIDENSPFYLKSAEDMLRERYEVVVFLEGTIESTGQSIQARSSYVATEVLWGHRFDQVVSFRKETGEYLVDYSKFNATNEVQTPLCSARDFAEYQRLLSEKSLNNPLAAATDNSNSTSTNEDNRDYKRSISSPLGGCNGTLPINLGQSTMDTPFNVGHSSLVPPFNLGPPIMETSLNLGPPTTVETPPADTPGSSGPPTVNTPLLCDMSNTSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UN86</accession>
    <name>A0AAV6UN86_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair and recombination protein RAD54-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein okra</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_017053</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts (via N-terminus) with spn-A/Rad51.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000349">
        <property type="protein sequence ID" value="KAG8185030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UN86"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000020">
        <property type="entry name" value="DNA repair and recombination protein RAD54B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="372"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="696"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8185030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="950" mass="107632" checksum="6113F762C759BBFD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNM2</accession>
    <name>A0AAV6UNM2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein axonemal assembly factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_024807</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cilium-specific protein required for cilia structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNAAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000323">
        <property type="protein sequence ID" value="KAG8185832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000166">
        <property type="entry name" value="Dynein assembly factor 1, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="315"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="712"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="832"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="938"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="719"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="945"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8185832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1538" mass="174691" checksum="65DBD169364BD29A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNP8</accession>
    <name>A0AAV6UNP8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_000719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000325">
        <property type="protein sequence ID" value="KAG8185732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNP8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="656"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8185732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="721" mass="80949" checksum="79182805C2992E42" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNZ0</accession>
    <name>A0AAV6UNZ0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Discoidin domain-containing receptor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_013012</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000340">
        <property type="protein sequence ID" value="KAG8185321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNZ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038062">
        <property type="term" value="F:protein tyrosine kinase collagen receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048680">
        <property type="term" value="P:positive regulation of axon regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05051">
        <property type="entry name" value="PTKc_DDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000007">
        <property type="entry name" value="Discoidin domain receptor tyrosine kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000053">
        <property type="entry name" value="Epithelial discoidin domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048525">
        <property type="entry name" value="DDR1-2_DS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF580">
        <property type="entry name" value="DISCOIDIN DOMAIN RECEPTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21114">
        <property type="entry name" value="DDR1-2_DS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="15">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="549"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8185321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="850" mass="95453" checksum="DD7039F15062ECBA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPP4</accession>
    <name>A0AAV6UPP4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000302">
        <property type="protein sequence ID" value="KAG8186412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPP4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="8200" checksum="686A9B2535D02239" modified="2024-11-27" version="1">MLRNEKFVCFLPPMEPTRKRPPKGDEEKRTFCGCESSWDSIPPPLRIWNVLLRILLCTKSPANSPLSLEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ05</accession>
    <name>A0AAV6UQ05_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000304">
        <property type="protein sequence ID" value="KAG8186372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ05"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1130" mass="125527" checksum="9BCA110DA024D90F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQY7</accession>
    <name>A0AAV6UQY7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000296">
        <property type="protein sequence ID" value="KAG8186614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQY7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="11598" checksum="379A2066CBE21EBE" modified="2024-11-27" version="1">MNNIYKTFDSDRVMSRGQSDLGPLWPPRSPDLSVCDFFLWGTLKSKLYSNNPQNLQELQQNIADEISAITKVQLYCAFRNMLTRAQRCQEINGGHFQHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URR0</accession>
    <name>A0AAV6URR0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000282">
        <property type="protein sequence ID" value="KAG8187002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URR0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9919" checksum="6DEBE100C9CA8044" modified="2024-11-27" version="1">MLSSHKKAPDHLQWCWCGRKIEAGVTASARSPKKDVYPLPRIGNTLDCLRGAQYFSSKDLHSGYWQIEVDEAYRGKNRIHHQRRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USP3</accession>
    <name>A0AAV6USP3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000270">
        <property type="protein sequence ID" value="KAG8187500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USP3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="66" mass="7752" checksum="36ED4C72AE710B3E" modified="2024-11-27" version="1">MTTPKKTPISQRTNVYSKPETFDKIEYRHYSLEVIVKDGVIASRWINKLQLARVRKGEYWGDGHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVG2</accession>
    <name>A0AAV6UVG2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">T-lymphoma invasion and metastasis-inducing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_008018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVG2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01230">
        <property type="entry name" value="PH1_Tiam1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01255">
        <property type="entry name" value="PH2_Tiam1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000065">
        <property type="entry name" value="T cell lymphoma invasion and metastasis 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055230">
        <property type="entry name" value="PH_Tiam1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043537">
        <property type="entry name" value="Tiam1/Tiam2/Sif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040655">
        <property type="entry name" value="TIAM1_CC-Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001:SF3">
        <property type="entry name" value="PROTEIN STILL LIFE, ISOFORM SIF TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001">
        <property type="entry name" value="TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23014">
        <property type="entry name" value="PH_Tiam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02196">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18385">
        <property type="entry name" value="Tiam_CC_Ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50898">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="57"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="RBD" evidence="8">
        <location>
            <begin position="343"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="420"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="646"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1041"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1106"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1192"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="183"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="618"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1053"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1074"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1128"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8188452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1212" mass="137002" checksum="1165C16F37C9101D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V249</accession>
    <name>A0AAV6V249_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000175">
        <property type="protein sequence ID" value="KAG8190725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V249"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="351" mass="39970" checksum="EE89F2A89718A27E" modified="2024-11-27" version="1">MHFSRQIWQFSSDLFCHQKRHLCYAASKTVEFASKNTKKGHCYNSLFPWNNQDEFSNYLASTLVYQKGGLIALNKPFGIKSLGKSDKRTKTKPSFIVSPIPECNFTIEDSLDSLKSILNVKKLSIVKSAERFTSGIVLLSCDDYTTNAVKKSLNIAKIQKTPALTHWMITLGYPVVNFREEKVALKFLEAENEEFKQPIIVTEFSKNEVKNKKVYPVHVIYRAICVNPTLQTSMVEISSSSVKWHFVRVYASSRIAAILGDAIYSNRMNTFMGMPVKLHIEQASAFGMPPISEDIAKALYIEKGIKGHSRIPTMLHLRSIFLPRFKNEDVTITANLPTHFQWTAEQLKLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2R3</accession>
    <name>A0AAV6V2R3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_001281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000177">
        <property type="protein sequence ID" value="KAG8190672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2R3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043731164" evidence="2">
        <location>
            <begin position="20"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8190672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="554" mass="64098" checksum="BB856EADA1064A72" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2S2</accession>
    <name>A0AAV6V2S2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Apterous</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_006025</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000194">
        <property type="protein sequence ID" value="KAG8190085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2S2"/>
    <dbReference type="Proteomes" id="UP000827092">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Znf_LIM"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="85"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="268"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="270"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="211"/>
            <end position="270"/>
        </location>
    </feature>
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            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8190085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="42962" checksum="252F86947CCF60AD" modified="2024-11-27" version="1">MSPTDGCMSDHSGTTGPGGGPVVLCAGCGGGISDRYYLLAVDRQWHASCLTCCQCRVQLDSELTCFARDGHIYCKEDYYRLFSVKRCTRCHLSISPNELVMRARDHVYHLHCFTCAACNRPLTKGDYFGLKDDVIYCRPHYEAVLQYDSPTHRVLKEEQHDRDLDGLGTGGVGGGAVMGLNQQIISLNGSEDHDRHLSLCAAVASAAAGVAKTPGQKGRPRKQKGFLSSSSLLLPHRGPSVCSGEDGSSPGLQLHLSDSSTSSEHHMSRPKRMRTSFKHHQLRAMKSYFSVNHNPDAKDLKQLSQKTGLSKRVLQVWFQNARAKWRRNLLRQQSQGPEIAQDCKPLSELASQPQFCDPFRLGSSSILDMQPTPITQEEQNIQTFTNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3P5</accession>
    <name>A0AAV6V3P5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_006081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3P5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF14">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE DAPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8191335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="13742" checksum="307380FF577FCABF" modified="2024-11-27" version="1">MAVTVCTRFSDNYELKEELGKGAFSIVRRCVQKNTGLEFAAKIINTKKLSARDNEPLDETYILKLYYFSENYVTGPVTKPNVSSIQFDVKPTLIIHILPQTCSKQPRVRCVVVSVKGGRMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3Q6</accession>
    <name>A0AAV6V3Q6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_006073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3Q6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8191325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="114" mass="12864" checksum="AE2409087662CB9B" modified="2024-11-27" version="1">MPRPTPLRPLLTKLLPFCLVVALLLVAFMSFHLVSGTWRRVLESRTTVGTRIRQLNAVADNLSRILMATETESALLNRDVGRFLKIVEKQVGEMKAAKEQQSSSRKQTLPSSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V585</accession>
    <name>A0AAV6V585_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_003278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000162">
        <property type="protein sequence ID" value="KAG8191267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V585"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="168"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="245"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="4">
        <location>
            <begin position="368"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8191267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="529" mass="59786" checksum="56A73A26E45E8E3F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5N0</accession>
    <name>A0AAV6V5N0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_025296</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000146">
        <property type="protein sequence ID" value="KAG8192030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5N0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058766">
        <property type="entry name" value="HHH_XRCC3_RAD51B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030548">
        <property type="entry name" value="RAD51B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46456">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46456:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26169">
        <property type="entry name" value="HHH_XRCC3_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="79"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8192030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="287" mass="32274" checksum="FF21FF1F9D8AFD3F" modified="2024-11-27" version="1">MGSYKIRRLNLPQLVIEMLEKQHLNSCKDVLSHSKLELQTLLGMNRYKIDSLWLEVCRKCVSTPQTAYDIYKSQQSSVSNGFLQTTLHALDLLLQGGLPFRNITEITGPPGVGKTQFSFMLSILTALPASMGGLESHVIYIDTESAFCAERLKAIARSKFPQLLMQEDETIKILKRIFLHKVNSVHDLKEILPQLETEVIRNNVKLIVFDSVASLVRKEFSSEGMSSLMERNKLLLELAATLKDLAQTYNLVVFLTNQIASHITEVDSILPVDCISDDEDNGTGKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6J5</accession>
    <name>A0AAV6V6J5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_029093</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000140">
        <property type="protein sequence ID" value="KAG8192360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6J5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13990">
        <property type="entry name" value="STKc_TLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000037">
        <property type="entry name" value="Serine/threonine-protein kinase tousled-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF23">
        <property type="entry name" value="TOUSLED-LIKE KINASE, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="411"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="54"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8192360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="723" mass="82963" checksum="B6FB70792C597BD7" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V753</accession>
    <name>A0AAV6V753_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000159">
        <property type="protein sequence ID" value="KAG8191471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V753"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="142" mass="15956" checksum="0E16953A798418A6" modified="2024-11-27" version="1">MINANPFKMLKLFRKSNISWSLLLQIGLLLLISATLSFGRQIDTNLFSNHGLQNNQFKSEWTRNLQSTPEILLPGQERFMLGSISNGAMSFGKLRLLSTLWKGMKTTGLQETVAGEVLQSFLRAALKDIIVPFKSELFSSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7E2</accession>
    <name>A0AAV6V7E2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000151">
        <property type="protein sequence ID" value="KAG8191825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7E2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF80">
        <property type="entry name" value="FASCICLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="122"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="283"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="432"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="622" mass="70391" checksum="426034F018E90371" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7E3</accession>
    <name>A0AAV6V7E3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_018034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000139">
        <property type="protein sequence ID" value="KAG8192514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7E3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF445">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF28.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8192514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="385" mass="43846" checksum="C77647E79138CCCD" modified="2024-11-27" version="1">MMEKLQQSSIMTDEDYEVESTVKTQNDCSSRKRKAKRICSKSFRRIDNLKNHQLSHNRKINPYVCYNCKKKFIRQTNLAKHKCSLAKKRFGQQSIQKNVVVLPENTGKSTKIVDNEPFNCMNERETSVNVVCPNETLDNMGAQNKIAFSFDNELIQGRREVTSKVESELPRNSNICSKNCTLTEKSLDIVEQNEITSEEVYVRNSIDCEITSACPEAKLADNKLNENVPPEMVLTDNPRNAVCNACPKDFCTNSSLKQRVHTQPSEKQHANHSCGKAPSQNCGFGNQIDQNITPTSNVYECEVCHEEFSKTSFLKTHFLAHSAEELEQVKKFLHLLPKNPSSVNKFKCDVCNKAFRDSCDIKRHLLKHTGSLKIVQNFEPISPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7N9</accession>
    <name>A0AAV6V7N9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">JTE90_007727</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000149">
        <property type="protein sequence ID" value="KAG8191930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7N9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10319">
        <property type="entry name" value="EphR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05033">
        <property type="entry name" value="PTKc_EphR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09488">
        <property type="entry name" value="SAM_EPH-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000089">
        <property type="entry name" value="Eph receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000019">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000143">
        <property type="entry name" value="Ephrin type-B receptor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1770">
        <property type="entry name" value="ephrin a2 ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027936">
        <property type="entry name" value="Eph_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016257">
        <property type="entry name" value="Tyr_kinase_ephrin_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF14">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14575">
        <property type="entry name" value="EphA2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25599">
        <property type="entry name" value="Ephrin_CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000666">
        <property type="entry name" value="TyrPK_ephrin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Eph LBD" evidence="25">
        <location>
            <begin position="20"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="325"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="425"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="637"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="23">
        <location>
            <begin position="924"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="762"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="643"/>
            <end position="651"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18 20">
        <location>
            <position position="669"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="69"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAG8191930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="999" mass="111499" checksum="A6CF761E02FB3375" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8S4</accession>
    <name>A0AAV6V8S4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Voltage-dependent calcium channel type A subunit alpha-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">JTE90_001744</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Membrane</location>
            <topology evidence="1 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000147">
        <property type="protein sequence ID" value="KAG8192016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009582">
        <property type="term" value="P:detection of abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009581">
        <property type="term" value="P:detection of external stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042045">
        <property type="term" value="P:epithelial fluid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000007">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000043">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000059">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000011">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 18" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="10 18" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="301"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="390"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="423"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="585"/>
            <end position="604"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="786"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="938"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1008"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1074"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1184"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1265"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1295"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1337"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1365"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1423"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
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            <end position="1581"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="1597"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1893"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="2035"/>
            <end position="2076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="829"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1755"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1896"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="2067"/>
            <end position="2076"/>
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    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="764"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1155"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069462"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG8192016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2076" mass="236232" checksum="E2022E4340D4DEB3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9Y1</accession>
    <name>A0AAV6V9Y1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondria-eating protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Spermatogenesis-associated protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_017981</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIEAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000139">
        <property type="protein sequence ID" value="KAG8192451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9Y1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035694">
        <property type="term" value="P:mitochondrial protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035695">
        <property type="term" value="P:mitophagy by internal vacuole formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026169">
        <property type="entry name" value="MIEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771:SF1">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="15">
        <location>
            <begin position="169"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="61"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8192451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="366" mass="41769" checksum="6176FC1C41451730" modified="2024-11-27" version="1">MYINIYSVRNRSHRSSSSSDNQSLTEGSSVSSAKGIIHRNFDIKPEGPLYCSRISNSPLDNRPLTKLSNSPSPSSQLSTRPLCKLSNSPTPSAQLSTSSHSTVSFQDSWQVTALRREVSVLKAELNQSQLNIEFLQQRERKIKERLAEQARLMMDRGMRFENVAMGGGRPTALIRRYGNLYAQSRVDTLDALDSIPELEHAHDLKSKILFSAVVLSFRSVYHTMCEIRSRIKHILQVNDERTPDPTIQELDHCITAHMKNSVDRFDLRKNLEEVLSQIWATLYDYPSLKNCDGLKHYVKDCVRLAWSLSNQCPPFVIEYEGRVFRKDLHVRFHSSNQESNHIKTYLWPTLLEGRNGPCVHKGVVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAC9</accession>
    <name>A0AAV6VAC9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exophilin 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000138">
        <property type="protein sequence ID" value="KAG8192596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAC9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="87634" checksum="FA7023AD9A254FD5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAS5</accession>
    <name>A0AAV6VAS5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PKD/REJ-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_005093</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000121">
        <property type="protein sequence ID" value="KAG8193446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730:SF1">
        <property type="entry name" value="PLAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730">
        <property type="entry name" value="POLYCYSTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043349995" description="PKD/REJ-like domain-containing protein" evidence="7">
        <location>
            <begin position="34"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1398"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="domain" description="PKD/REJ-like" evidence="8">
        <location>
            <begin position="684"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8193446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1457" mass="159991" checksum="4804099B110A091E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAX1</accession>
    <name>A0AAV6VAX1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000114">
        <property type="protein sequence ID" value="KAG8193825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAX1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7696" checksum="BC197576194C5BD8" modified="2024-11-27" version="1">MIANIEVHGADKDEGGYCCFLLRNREVVLPGKNITAAGRKEETKNSGFVVDEGRKCYEVVKFNPLHRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VB21</accession>
    <name>A0AAV6VB21_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000113">
        <property type="protein sequence ID" value="KAG8193870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VB21"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="129"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="293" mass="32771" checksum="3EF33A78F27C3285" modified="2024-11-27" version="1">MSLESKGVNDDYGIALALTITERCFSFVDCNFVCDCITAKKTRNCTSIEYNDLRTEYKEWWIVKSGVTRNASCKFNLQLDTIVAHHNNSQCQITHPTSSAIAKIGGSSEAVNDPLRIDLLHLYRDGILSDATINTEGKSFSAHRSILAARSPVFRAMFEKDEMSEGRSGVVDIDDVDSETVDRMLVFLYGDSLQGLQWGEAASLYYVADKYAIQPLKQKCADILKTGLTVDNVCDALVLADTHSDEQLMKSVVDFIYDHQEVVSSPKFEQLEDIKPRLTSKVTKELFLKIGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBI1</accession>
    <name>A0AAV6VBI1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_028378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000110">
        <property type="protein sequence ID" value="KAG8194035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBI1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11779">
        <property type="entry name" value="SH3_Irsp53_BAIAP2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000188">
        <property type="entry name" value="Insulin receptor tyrosine kinase substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027681">
        <property type="entry name" value="IRSp53/IRTKS/Pinkbar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206">
        <property type="entry name" value="BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206:SF7">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 53 KDA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51338">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="IMD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="344"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="550"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="557"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8194035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="69665" checksum="EBB37D9DB62BCDF9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VC09</accession>
    <name>A0AAV6VC09_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_028376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000110">
        <property type="protein sequence ID" value="KAG8194032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VC09"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8194032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="289" mass="33875" checksum="9844572F5722664B" modified="2024-11-27" version="1">MDGCQLIRGLTFPPHQIFPKQNIEDTLDYVPHDGDIVIASYPKSGTTWLQYIVLQIISKGEHFPSMDALNEVCPFVELVGTKSVEELKEPRVYMHHCPYNMVKKNPKAKYIYIYRNPEDVFVSYFHFLQERRGRSLDFELYFEGFLSGNIGYGRCFEHVLSYWQHKDEDDLLLVSYEKLLINRKEEILKIIKFLGESFHQAILSDESALEKIIEHTSFDYMKRNLTMFNSNLSKNDGHSEREVSQINFFRKGVIGEGKRSLSRDQLKRLRKVMEDVLEGTTLLEEWAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCN6</accession>
    <name>A0AAV6VCN6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000103">
        <property type="protein sequence ID" value="KAG8194429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCN6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7455" checksum="984BE8C91AD083A4" modified="2024-11-27" version="1">MLKNALIAVSGSCVTLNLFRESAFTWINVQRSQGPEACEVCPAHREIGSLTNHPNIPVTPRGIDPLLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VH31</accession>
    <name>A0AAV6VH31_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_027960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAFNEN010000091">
        <property type="protein sequence ID" value="KAG8195219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VH31"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044000660" description="Alpha-1,3-glucosyltransferase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8195219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="464" mass="53156" checksum="411626B3B569CF02" modified="2024-11-27" version="1">MLINGVDDLMHFGVLLSIILRWAVSRFPYSGAGKPPMFGDYEAQRHWMEITVNLPVQQWYINSPENDLLYWGLDYPPLTAYHSMLCGYVAKWFNPDWVALNTSRGYESYHHKIFMRSSVLISDLMFYIPLILYWTTIQRPWNLRNKAIAAGLSLLYPGLILIDHGHFHLGLTLWAIVLLMWECDLQGAACFTLALHFKQMSLYYALPFFCYLLGTCIRLKWKKGALKLFSLAFVVITVTCICWLPFLRSYEGAIAVVERLFPFSRGLYEDKVANVWCMLSIIIKWKSIFPLSTLATISAICTLVSAMPSCIQLMRNPSLHKFRIALINSSLSFFLFSFQVHEKSILFSALPVLLLIEDHPLTCIWFAYISTFSLVPLLAKDGLIIPYIALSSLFLIGAIRAYEDLLISFKTQQSKIASLSFCISILGSLILLTFVENQSIDYYLLPAENRTVFIAPLDKITRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VH85</accession>
    <name>A0AAV6VH85_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000089">
        <property type="protein sequence ID" value="KAG8195335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VH85"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043496211" evidence="1">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8924" checksum="D39701FCD37661DB" modified="2024-11-27" version="1">MELKQLLKTTFLLIAFLCAAPVQAHHHHHPMWKMMKKMMKHHYEEPAKFLGIKSIFVPIPMPVNVDLKKISFMKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHE1</accession>
    <name>A0AAV6VHE1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_001408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000089">
        <property type="protein sequence ID" value="KAG8195395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="61"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="185"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1219"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1039"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1125"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1048"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1125"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8195395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1316" mass="150844" checksum="732BA6118AC31154" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHS0</accession>
    <name>A0AAV6VHS0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_019501</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000085">
        <property type="protein sequence ID" value="KAG8195512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHS0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8195512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12521" checksum="5CA75314D48C6453" modified="2024-11-27" version="1">MTVGQHNEILALLNSKMRVVLCDNRTFVGTFSAYDKFMNVVLTDAHELKKYKAKRKPPVEGKQHHDCLVIRGENIVSIIIDSDPPRPDRGDRDRDRDGGSSSRSHSRGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIY5</accession>
    <name>A0AAV6VIY5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIH1D1/2/3 CS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_012274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000069">
        <property type="protein sequence ID" value="KAG8196450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIY5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026697">
        <property type="entry name" value="DNAAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041442">
        <property type="entry name" value="PIH1D1/2/3_CS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21083:SF0">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21083">
        <property type="entry name" value="TWISTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18201">
        <property type="entry name" value="PIH1_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1D1/2/3 CS-like" evidence="2">
        <location>
            <begin position="92"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8196450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="196" mass="22144" checksum="BB7E1F1C360EF863" modified="2024-11-27" version="1">MEDFGTSDIRHLVNLLNLDENGNSDEDSDIYPIRTQNPYSMISNTTPANCVNVELAEQPKNSYGNKSAISKDIWSEDEILPEDYDESQIKEKPEHEMVYHQKVTPDDIILQLDGKGPGTNSCECLLVKIQLHGTNSKDDITLKISSLSLICKTEKYYLNLDLPRQVDPSKCVSTWNVLDCLLSVNLTFEEKGVLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJD8</accession>
    <name>A0AAV6VJD8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Speckle-type POZ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_027610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJD8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045005">
        <property type="entry name" value="BPM1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26379">
        <property type="entry name" value="BTB/POZ AND MATH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26379:SF187">
        <property type="entry name" value="OS07G0655300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="28"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="348"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8196905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="60122" checksum="71B4718ADAA55EB2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLH4</accession>
    <name>A0AAV6VLH4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">15-oxoprostaglandin 13-reductase</fullName>
            <ecNumber evidence="2">1.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_007228</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000054">
        <property type="protein sequence ID" value="KAG8197489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLH4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF3">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="37"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8197489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="363" mass="39636" checksum="ECDDA59F263DBB19" modified="2024-11-27" version="1">MCHVLSVSILSWKSSVSKMAEKQSSFKKLMVHEMTTDFRKAVKIETIEMCHPQKEQVCIKIKYVGVNASDINASKGRYFTTGILPYEIGFEAVGEIIEVGEGVEELKIGQSVALLKSGSYAEYVCVPAKEVFPIPEATPKYLTLLVSGLTAAISLDKAGHITAGETVLITAAAGGTGHLAVQWAKAAECHVIATCSTKEKEDMLKDLGCDRIINYKKENLAEVLAKEYPKGVDVIWETIGGQMLIDCVKNLAIKGRLLIIGGITGYKSEEKNALPKLDLSFLPEQLLMKSAAVQGFLLFYFTDCFPTYFKYLCENVQSKKLTPLVDTGLSTPEGEFVGMEGIIRGVEHLHSGKNVGKVVSRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM98</accession>
    <name>A0AAV6VM98_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_006815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000051">
        <property type="protein sequence ID" value="KAG8197774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM98"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8197774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11949" checksum="2C65E37D5C05D987" modified="2024-11-27" version="1">MEELSNNFDTSASLGTIPEEHRKTPCRMQTDRGSTRCSSTSNSKNRPVVRRHMCPLCQSRYKKKCHLMVHLRVHTGEKPYSCITCGKAFSRSHNLHRHERTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMY2</accession>
    <name>A0AAV6VMY2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_001879</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000045">
        <property type="protein sequence ID" value="KAG8198045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMY2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000001">
        <property type="entry name" value="Calpain-1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Calpain catalytic" evidence="9">
        <location>
            <begin position="136"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8198045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="541" mass="60994" checksum="31000A60F2441F81" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNP4</accession>
    <name>A0AAV6VNP4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_021546</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNP4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF471">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="29"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8198292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="678" mass="74428" checksum="127744C4F8C71C89" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNY6</accession>
    <name>A0AAV6VNY6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_006509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000050">
        <property type="protein sequence ID" value="KAG8197810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNY6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12934">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03020">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LEM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8197810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="241" mass="27809" checksum="683FCA81F131CFB2" modified="2024-11-27" version="1">MSVITDETLREQLILYGEDVGPLNSSTRLYWEKRLAKLNKSSNSKEKQLSNAKNFKSSIKYSSKKNKIKKPEKKPVKIQQRDKILLDSLRENGLNILRGPLTDAMRNEYQKKLNSLMLEAAPGHKDIENKLISNQRDSTVDSEDGDLKKSLLHYGVSVPNGPLNDATKHQLKKVWYKLMMNEKGILSEIDLRDAFEEDNHDSDSLESDPRIRYWAFIKTLFSFMTKLTLLLTPQYSPSLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSQ8</accession>
    <name>A0AAV6VSQ8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSQ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="269" mass="32230" checksum="0EBB03D254CDEC9E" modified="2024-11-27" version="1">MARLGQTWDKLREEIMESIEENGFLLKIAEEEFGEIPFRNAVYRMFQNQMMEDWDLEREDASKIEERRKAIHRRVIERERFVITRTREYLETKVKMEELQSERVNPDLDYIFENLKYSSREDEIDAFVKAFERNLFISCEVDLENLLHDRNLIFKKILLTLQNAPRKALYRRYDNLTKAIQRIMARTGDKYTRFLCEDLHVVFVNIRKKIQNIVRFVPLDLGFSGENIKFVFISGRKGREEERIRTFLLLNHQTFAASLVRKSSAFGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSY4</accession>
    <name>A0AAV6VSY4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSY4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="115" mass="12825" checksum="0A70FD00A897C1A0" modified="2024-11-27" version="1">MMIFFHLSCWMNSYKDRLDNNNQTNVMVGNFLLSVNTETLEVLEYIDTSFNDSSSNSTKVELHPGSSIEAIFLVAATSSCEQCVITTLTNRLIIDHATDALLAVDIPSQNNTNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT93</accession>
    <name>A0AAV6VT93_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_003689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000029">
        <property type="protein sequence ID" value="KAG8199266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT93"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="49"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8199266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="496" mass="54819" checksum="36B9D23FEABE837E" modified="2024-11-27" version="1">MTADVSWVKCEAISNEKNNIRLGISKEDQVFSVDDAVNKVGFGKFQKKLIFLASFGWLADAFEIFILSVIGDLVACDWILYRWQSALLSSIVFAGIMIGSPILGFIADIYGRKKCLCASVVLVFVFGSASAVTPSFAWMAIFRSCLGVSLGGIAQAVTLCSEYCPNDMRGKTVFYMCYLWSFGSLGVILLTWVVMEYTNNWRLLLALAAVPSLIVIFSLKFYPESARYHLVSGQYDKACAIVAKMAGTNRRDLPPGKLVRVEVKSRGRLRDLLSSEHRRTSLLLWLIWFGSAFAYYGIIFISPMVIKHGGLRDSANKDVNLNLTSIGFEMLQVLPCVRFTQQDYVDMLLTTAAEFPGILIYTFLIEKIDRKKLLGFSCLVSSMFCMLLLMKTHRIAILTFLFISRGILVAIFQLNYVITSEVYPTTVRAVGMGAGTAFCRLGGLIVPYFAQVLLISSPVTAICLLSGMLFASGVAAACLPLETRGRGMKESSAQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTD7</accession>
    <name>A0AAV6VTD7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000028">
        <property type="protein sequence ID" value="KAG8199298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTD7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="8038" checksum="7B6B0087DA62703D" modified="2024-11-27" version="1">MKREREIKTFVKDIICDIDMLVRCIFNLVLQILSGCHYCTPWTSIAATQVTSEFYWGRRSALLVKIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTT1</accession>
    <name>A0AAV6VTT1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000031">
        <property type="protein sequence ID" value="KAG8199119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTT1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="85" mass="9524" checksum="6A2131FFE2E79EE5" modified="2024-11-27" version="1">MPARIEQMFIFNVFDAHLWEPSAGGCGWTEQLGSGLISRALDIGPYPIHMHDSVYGAQGTLEGPDAAASCRDLEWILPWRRWPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUN0</accession>
    <name>A0AAV6VUN0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP-5 complex subunit zeta-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_009320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUN0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044599">
        <property type="term" value="C:AP-5 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028222">
        <property type="entry name" value="AP5Z1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055450">
        <property type="entry name" value="AP5Z1_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056856">
        <property type="entry name" value="TPR_AP5Z1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056857">
        <property type="entry name" value="TPR_AP5Z1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46488">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT ZETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46488:SF1">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT ZETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14764">
        <property type="entry name" value="SPG48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25153">
        <property type="entry name" value="TPR_AP5Z1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25154">
        <property type="entry name" value="TPR_AP5Z1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP-5 complex subunit zeta-1 N-terminal TPR" evidence="2">
        <location>
            <begin position="42"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="AP-5 complex subunit zeta-1 ARM repeats" evidence="1">
        <location>
            <begin position="274"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="AP-5 complex subunit zeta-1 C-terminal TPR" evidence="3">
        <location>
            <begin position="408"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8199472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="84649" checksum="6F2E39392F762C9E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VV49</accession>
    <name>A0AAV6VV49_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VV49"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="9475" checksum="EA63EFF4DE245FE8" modified="2024-11-27" version="1">MIMDESAEEGMPALGSIPNLTPGPDTVEVARRNEQDKKKTKNDILNKLCDEFSRANQAMEKNDERIIKLLEQQNYLLLKISNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZ41</accession>
    <name>A0AAV6VZ41_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZ41"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="108" mass="12087" checksum="7F180D6BD28EFFFF" modified="2024-11-27" version="1">MEEEWPCPDTTDQEVYLDKWLEPVHVDTGRANKNKAELGRIFFGGVCQTAFVLGCDGVRCTMNSPLKTLSGFDSHPPNAFINENGYTSVTHSALYCALKPYFTPKRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W2V7</accession>
    <name>A0AAV6W2V7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W2V7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8202118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8062" checksum="AD5689CBF6EDD6B0" modified="2024-11-27" version="1">MFPASANLINVIEYFSTGIIIASTQLPTIQAAHGVMKTELLFLAKLSRAAVTSEAIAPAHWQPPPAQAFLGSWLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDZ5</accession>
    <name>A0AAV6TDZ5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006257">
        <property type="protein sequence ID" value="KAG8156173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDZ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8156173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="700" mass="78829" checksum="C709123F70F95707" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TE91</accession>
    <name>A0AAV6TE91_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">exodeoxyribonuclease III</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_028687</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9 11">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010006392">
        <property type="protein sequence ID" value="KAG8156017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TE91"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00195">
        <property type="entry name" value="exoDNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="EXODEOXYRIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250:SF2">
        <property type="entry name" value="EXODEOXYRIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="12">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="10">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8156017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="259" mass="30188" checksum="D84ADE82412E1F2F" modified="2024-11-27" version="1">MLKIATWNVNSIRKRVNQLCSFIVDSQIDIILLQEIKCTEEQFPYAEIEKLGYEYAIYGQVARNGVCVLSKYPILEKLKIDIVEGHQEARYIECVIKHTNYKIRVGSVYVPNGQSLDSHAFEYKLKFFDNLYERMSTLLKNEELTIIAGDYNVALDEIDVFDSNLLNGQVCFHIKEHEKLRAVLNLGFKDAFRISHPNLQQFTWWHYQGNSLRNNQGMRIDYMLLSPQAVDKLETCYIDDRLRKLENPSDHTPVVCAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TG17</accession>
    <name>A0AAV6TG17_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_015259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005477">
        <property type="protein sequence ID" value="KAG8170431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TG17"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043361235" evidence="2">
        <location>
            <begin position="18"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8170431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="324" mass="37536" checksum="69C6F762C6E8EBB0" modified="2024-11-27" version="1">MAHSILLLWCIASTVASQAFIPAARVRRDISDTTQPAELITTESPTDEEKATTIEETLTTFFDAEKDLRIRARKVEESRFLDFFEFEARRDEARRAARTTAEDPRIRATTEETKSTTEGVQANETESAEYTLDKSLMQNLLVFMEAEYKCRQEVTRLLTEETTRMKEILEEFDAKEETRTLAHTEEENRKFFMYLRQKEQMEDFSRAKKEAAKRADIEEYERNAQANYTSEEDREVQVAVGAWKVKMAFAEAARMEEAVLDFQEKMQEQIHASIIEEGMKWEIHQQLRAVLSDILQHQTAKRLAEKDEGNAPTMSTTAVEQTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TH30</accession>
    <name>A0AAV6TH30_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004390">
        <property type="protein sequence ID" value="KAG8171128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TH30"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="124" mass="14248" checksum="676FE8FB6BEECD0A" modified="2024-11-27" version="1" fragment="single">LILIYLEEIWVNSLLQLQREQTPYLVEVDVNESPALQLTDEEFKRNTNAKIGKVLYQPKILAEQQQIILLNQEKILGLLLQKESSLPQLESEDMRKMFPLKTVQDLDDLSSLIAEEGENEAIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIG6</accession>
    <name>A0AAV6TIG6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003809">
        <property type="protein sequence ID" value="KAG8171572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIG6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="128" mass="14631" checksum="DBE068FB1CF3621A" modified="2024-11-27" version="1">MGKHQLRGFSINKEICVENMSHKTLISRRAIKDLLNSVGGASNVHITKELLFNVASARSRYEHYFARGEDEKRQAVVLECLKTKRKRLEPCAQYLEKSADECAEKAENTQNFSFIAKSNALQKIKMQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJ42</accession>
    <name>A0AAV6TJ42_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003918">
        <property type="protein sequence ID" value="KAG8171481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJ42"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13703" checksum="793B0C0D8C866F73" modified="2024-11-27" version="1">MFLRFRKKPFHHRGTPTIKGPLYLILPQKYCHKIKYETSHSRQTVLDSPRPALHIAAGRGNNKGRKGRQASRVGHAHGIQLTPTRSPMLRSQYAPYSHRNNFRDGAARHGGPDTRREAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJ70</accession>
    <name>A0AAV6TJ70_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003572">
        <property type="protein sequence ID" value="KAG8171787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJ70"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7936" checksum="44E2D3FFA7A152CA" modified="2024-11-27" version="1">MTHVQTAVHMEPFSSFSPQGSHLSICYYHQDLHRWRLSRRAHARHLQRTPPRTLLLTAAVNLHEEALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJM5</accession>
    <name>A0AAV6TJM5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003554">
        <property type="protein sequence ID" value="KAG8171798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJM5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="146" mass="16001" checksum="8D0BFB504B237B8B" modified="2024-11-27" version="1">MGLAPTLGNSPGQGDLLQSPSPARSLLNATFPHALASGDSALGFSRFTRRKSLSTIEGPPPSKWPLYLILPQKYCHKIKYETTSHSRQTVSRLTTSRAAYCSGGEETTRVEKDDKRVELATAHGIQLTPTRSPMLRSQYAPYSPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJY2</accession>
    <name>A0AAV6TJY2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003492">
        <property type="protein sequence ID" value="KAG8171836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJY2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="96" mass="11036" checksum="EDB6E63880908305" modified="2024-11-27" version="1">MIKWPKRDLKSFPCQNKGAPETGKIFYLKTETFSPNIWATLPRHPPPDLWHGENPTGKKKLSSWGPLHLLPDSVPFRDWGTLPQTPDLCWITFIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKI6</accession>
    <name>A0AAV6TKI6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002801">
        <property type="protein sequence ID" value="KAG8172354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKI6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="275" mass="31486" checksum="8AE1B274F01F766E" modified="2024-11-27" version="1">MCCNSSFILYVVPANEPDTIAVLPPSPARIVVSQHPGASAGGPMRTRRWLRPASPTDREAAATARGQARNNSGTRRNPYQRPERLAAHRLQHPETQQNTTNFEHQWRTEFVAQAWHHEPELELREFPEVYRVPAPLRRLGCQFLPDVPSSCRIASPRVHFYTRRAGDKSRDQATQSPIKETRTSFARDECGDMAQLTGLSTFQFCHIRMTLNFSTNLKRLFSSYFIWKWTNTSLSLLHQTSLEENPHEDLNHPTMTNLLTTTKQIFIGKYSNVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TL75</accession>
    <name>A0AAV6TL75_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_002913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010002635">
        <property type="protein sequence ID" value="KAG8172522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TL75"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="4">
        <location>
            <begin position="13"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="5">
        <location>
            <begin position="409"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8172522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="464" mass="50488" checksum="CB18C8361CEA2C08" modified="2024-11-27" version="1">MDKKTRIESDSLGKVKVPSEHYWGAQTQRSLENFKIGTEKMPEPLIKALAIVKLAAARVNMKQGSIDNKVGDAICASAREVMDGKFNNEFPLVVWQTGSGTQTNMNMNEVVSNRAIEILGGDLGSKSPVHPNDHVNYGQSSNDTFPTAMHIAAAQQVNHLLIPNLEELYKALNNKVQEFKDIIKVGRTHLQDATPLTLGQEFSGYAVQIKKGIERIKSTLSNIYELAQGGTAVGTGLNTKKGFAEDCAREVAKITNLPFTSAGNKFEALAANDALVELSGTLNTVAVSLIKIANDIRLLGSGPRCGIGEIMLPENEPGSSIMPGKVNPTQCEAVTMVCTQVMGNHVAVTIGGSNGHFELNVFKPVIIYNVLQSIRLLADASLNFTEKCVVGIKANEERIKDLLNQSLMLVTILNTHIGYDNAAKIAKLAYKENITLKEAAAKLQLLTEEEFERIVKPEEMVNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TL95</accession>
    <name>A0AAV6TL95_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003031">
        <property type="protein sequence ID" value="KAG8172160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TL95"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="154" mass="17723" checksum="FB55F06C04BE1C5D" modified="2024-11-27" version="1">MQYAFGHTLICPTIDQAGEVCFNHLIKKETVSLDGSIFSPQGTLTGGSIQAGDTVLEKLIPCPKLKEALERKQNQLSQLQKDISNMKIVKQRYDSLHEDWELKENEAQLLKSKIEQSTYHKQLQEFKDMQQSYEDHKTQLADCKEKQKKCCEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLE6</accession>
    <name>A0AAV6TLE6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002384">
        <property type="protein sequence ID" value="KAG8172785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLE6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043720012" evidence="1">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="201" mass="22324" checksum="15240A8CFDE25989" modified="2024-11-27" version="1">MQVAFAVLFVVILVQGDADADVTCKLPTPVEKFAASYYTAMIVGHDPDIVDTLSVSGDEAAMLPYRVVKKALDAFKYGRCDGEEIGFIASRSVSNIANLTMPRYFEMESRTVGSILYKFGVMDCSNAVPLALEFLTYSREDAKKYKLDPYKFDSFMHEIIFGGIRLHKAHGLNLDTVSAPAVDTFHQFSTEDRKVNQHCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLJ1</accession>
    <name>A0AAV6TLJ1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002312">
        <property type="protein sequence ID" value="KAG8172830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLJ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="143" mass="16730" checksum="5113C79E24F4F0FC" modified="2024-11-27" version="1">MVQRFLRKNDVQASSEMLLFDCLNILETRKDLKDLWEKTNDLFKGANIADFLAHGNPILQTIGNILREEDLPSEFIGNIMELIKDVDAMRALSEMWVKTKLCKESKFLAAVESDEQDEHMDLRKRIKKCSRWKEYASLLPLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TM16</accession>
    <name>A0AAV6TM16_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_024123</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002326">
        <property type="protein sequence ID" value="KAG8172822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TM16"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="14">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="270"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8172822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="479" mass="53515" checksum="7B0FB02F5C6558C1" modified="2024-11-27" version="1">MVKGCCVPFCNTQRGNKISLHEIPSDLNMRTEWLQAIPLKDFIPLDHSKVCANHFQKSDFLSSCRAKRLKKNAIPSIFEGCPTIITDKGKNYVVKQSSKHSSDFELVQTSESEKSQTQINLSSVPSKQVTELNSSPINSVGSRFNLPSIVVKQPITPSFFMKKNVKSIYVLDKNKTTTPMKEAAQTVTNKCTSFNIENNYPGLLKRKADVNNCVNNNAKMLIISSTPKNKAVSFSVQSTCSSNETLSVLDTEKGTTSASQLSHQLVSQGLPSDDEAVTTSDMNNEGVGGVGNAESETEMNQRNVPSNRFTGITNNRSNQAGTQINHSRVTTSAASRELSKQTSLPTKYFNANSYKFISELRHKNKNMISLLCKKNKKIRLLQSKLEEMSEKLEYFENHEVMRKVEKLLVINDKGLASNQIKFLLSQLSNLDKKTPRWPDDIVRECVLLHASSPKCYEALQKSELIKLFLKIVIFSSSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TN34</accession>
    <name>A0AAV6TN34_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002014">
        <property type="protein sequence ID" value="KAG8173168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TN34"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="113" mass="13206" checksum="DD262B277D6D3572" modified="2024-11-27" version="1">MFSSIIETKNSWTCDECKSSKTSTAADSNKSFQKEILDQLQEFKRSLDFNSKVLEEVVKSNKNLQEELQNIKKENYQLIEENKQLKTQIAEIKNDVIDLQQYSRRLNVEIALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TP49</accession>
    <name>A0AAV6TP49_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_004727</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001801">
        <property type="protein sequence ID" value="KAG8173399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TP49"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8173399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="216" mass="24379" checksum="D963640846AC385C" modified="2024-11-27" version="1">MIKVCDDFENRCGIPNVLGALDCTLIKIASPGGDTAERFRSRKSTFALNVQTLSDVELSIRNLVVRWPGSTHDSTILDHSYLRAHLEVDLQEKYVVLGDSGYPLRSYLMTPFLNPANIHQRRFNTAQILGRNVVERQYGVWKRRFRCIDSKLRCRLDNAQKIIIATAVLHNIAIGKGDNYAAADDYEDDDVDSINYDQTNGGVARRNAIVAARFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPA9</accession>
    <name>A0AAV6TPA9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001677">
        <property type="protein sequence ID" value="KAG8173518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPA9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="10315" checksum="EB3EF585D977465A" modified="2024-11-27" version="1">MLRKRPKKCRPEIKLELDVTSELDVTSELDVSELDVTSDICPKVDDLCPTVEITESIDDILNKILVEFCTYEKLIEVLSNICVENKFVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPH3</accession>
    <name>A0AAV6TPH3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_016429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001663">
        <property type="protein sequence ID" value="KAG8173534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPH3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16510">
        <property type="entry name" value="RING-HC_IAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051728">
        <property type="entry name" value="RING-FYVE_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879">
        <property type="entry name" value="CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="62"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8173534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27096" checksum="F371A98EE738B6D7" modified="2024-11-27" version="1">MKEHLSRVHSDKVSKELSYFQQLKAKADKQSNVRELFKKQESDLDKGLLASYEVSLLIAKCENVIRSNFSEYGDIEEVSLFHNYGFIRFSTQVSAALAICARDQHNIYEGEVRCNWAPTQPVEAAAPSTSVTHRISQLRSEPDIRYSGLATASVPESVEPNRATNAKETEVEGKVEVTKVDKKVEETKTVDFQCKICMDEQVGVVFLPCGHLVSCPRCAQRISNCPMCRKQITALVRTYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPY3</accession>
    <name>A0AAV6TPY3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase p58-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001427">
        <property type="protein sequence ID" value="KAG8173920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPY3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase p58-like C-terminal" evidence="1">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="285" mass="32030" checksum="2C8DDB2671F9A925" modified="2024-11-27" version="1" fragment="single">MQRVYNSVYQNLENVAAKQSRLRDKIAKIKTFEIGQKVYLYTPATKQSTGRAFAKKISGPFRIVKKHSDLNYTIQESDKPFSKSTKVHVDRLFDYTERRPDLQIPAQSNTGNFNNATGLGTSYSHYNDTNQFSWYDDAEGTDILMVTHTNTEVHNRIEKGQTLSQPTTQLDHATIPKQTKVEKKREFNASVVAQLILVALMSGISVASKAHICRQAENSSYSCEMVSSEVLESYNLDLPDNACAATSCKDCVVANASFIITEKDELMHPTTFLDRPTDRLGNKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQV2</accession>
    <name>A0AAV6TQV2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA-binding protein FUS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001263">
        <property type="protein sequence ID" value="KAG8174274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQV2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="9212" checksum="E2CEA4269B438637" modified="2024-11-27" version="1" fragment="single">MGDQQYSGYPANQAGGYSYGSYGGDASYSQPAYGGATTGAYAGSTSTNQWSGSAAPAQSAAYGSYGATDQYGSSQQYNYQQQPAASTYSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSX7</accession>
    <name>A0AAV6TSX7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001153">
        <property type="protein sequence ID" value="KAG8174749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSX7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="145" mass="16558" checksum="37FFD237FA6C6E03" modified="2024-11-27" version="1">MNTEKTKRKSLRQSFTVCASNAKAALDKAGTTVTELSSLQRQLLDKYSRLEEVQEIVAQSLLTDPSKTTEYENDFETAEQYRDTFADITTQLEARINIAAAPSESGRDSTAEKRNFKLPRLELKKFTDTMEKKQPRSIYIKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTU5</accession>
    <name>A0AAV6TTU5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001089">
        <property type="protein sequence ID" value="KAG8175033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTU5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043451032" evidence="1">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="117" mass="12849" checksum="1289933A529BAE05" modified="2024-11-27" version="1">MTPLVKALVLFQTIFAFLCVLQSTAELVNLGNVAIDTAVGKVRGQSLTLAGDNHNNSSRLFYSFLGIPYAKRFRAQSGQYLERTCSERTVLEKWNLPTTLGPSGWGQSISTTCSWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUL1</accession>
    <name>A0AAV6TUL1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001016">
        <property type="protein sequence ID" value="KAG8175384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUL1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="176" mass="20313" checksum="83F4DC8D99F99856" modified="2024-11-27" version="1">MSALVKLSESLPQVLESSEKATFVEEVREYTVDQEIDNLENLGVYSKCDNMIIDLNWWSHIFRLEQDGELKYKVLPKLVKAVITPFSGPLVEGSFNIMDDIITADRSTLTVENYEAIYTIKYNLRRQKLKAIDLKPNVNMRKAIHTAYTSYKEHISKKKLKTSGNLPMPQMLKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUT4</accession>
    <name>A0AAV6TUT4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001048">
        <property type="protein sequence ID" value="KAG8175239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUT4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="25390" checksum="E015E6F875471850" modified="2024-11-27" version="1">MESLNRVSSCPLIGPTINSSPLYVRYHNLIYHRKACLVTCPFSCSGDPMSFGEFLRVHMKEVHQVNASHACPFCLGRFQWLRQEARSEEVNRHRLECMKALFPELFHSRVPKIRPNDKQREQSQLFAEIKQLHHNLVCEGSESKLKEQIRNLLLDHDAAEITKLRAQLSTLEEARNQREQLIQEKEQLIQEKEQLIQMHEQLSFSLREHQQKLVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVF0</accession>
    <name>A0AAV6TVF0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_002860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001006">
        <property type="protein sequence ID" value="KAG8175430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVF0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043361239" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="368"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="518"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8175430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="620" mass="70722" checksum="7C96862F45F752AE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVS6</accession>
    <name>A0AAV6TVS6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000948">
        <property type="protein sequence ID" value="KAG8175844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVS6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8617" checksum="3FA9384B7638E698" modified="2024-11-27" version="1">MHSGSSRGGACSKKMMLSSTTCSTRSSCILHNICHELQEEFLYEWIKGVVLDTDDTAVFTAADSSDARHLLVYWCAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TW30</accession>
    <name>A0AAV6TW30_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000938">
        <property type="protein sequence ID" value="KAG8175949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TW30"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8929" checksum="7F8CF99F4A0C60DB" modified="2024-11-27" version="1">MNNHLKNQHKAIISRNFMTAETAYNPPTTTTNHAELKGSKLDHRLLEQYIHPEFQRLTSQRLKILLKHNQNVPENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TX02</accession>
    <name>A0AAV6TX02_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000930">
        <property type="protein sequence ID" value="KAG8175997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TX02"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="468" mass="53918" checksum="919AB82F8FEE4421" modified="2024-11-27" version="1">MDAMKDKVITYLSGYNADCLNQTTDIHPNKRSSVVALNESSSTNNTDIYSLNQTNFANAMNETNEVYNPDCVSAPTGDEPPKKVPAKRGRKIKNGLKSQWRREKCNKYLNKPYKNYKGLEIKSKEFVDYDCGCQLKCSEVLSANDRKQEFQKFWELGSYEAQAIFLVARVDEQVTKRSLRVRKRKKKVVSETEDSSDGPDTDGSPEKEKKKKKDPEPEVKKSKRQFSRTYILKAKQVCRTMFIKTLGITSKRINTALVKMRKKSLTDHRGLSQGGKNRISDKRHQEVIDHIKKMPRYKCSHVQGKMDSEFLPPELSLSKMYDIYSKEVEQPVSLSMYKKVYYDKFSFKSKGSKREVCNICKGERKSKTDTSKKRNNSNNNNNQTPEKQQYTFPSSPEENIVLQQHQYRPNFIGASSINCNQSWLATPNFQMTQHNPTNYFEQQLSYTNTNFDGQQGQGPARLIHTNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TY39</accession>
    <name>A0AAV6TY39_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_005730</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000831">
        <property type="protein sequence ID" value="KAG8176985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TY39"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03858">
        <property type="entry name" value="M14_CP_N-E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000013">
        <property type="entry name" value="carboxypeptidase N catalytic chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF93">
        <property type="entry name" value="CARBOXYPEPTIDASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043563354" description="Peptidase M14 domain-containing protein" evidence="14">
        <location>
            <begin position="16"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="15">
        <location>
            <begin position="25"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8176985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="339" mass="38185" checksum="3464706BDF52C769" modified="2024-11-27" version="1" fragment="single">MMLLLLFALIANVSCQKPLWQESLTHFNNAELQEYLLKVHQQCPDITRVYELNQSSVKGWPLVVIEFTSKPGKHQELKPEFKYIGNMHGNEVTGRVLLTSLAGYLCDEFKNGNKDIQRLINITRIHILPSMNPDGWDIATQSGGKDWLAGRENANGQDLNRDFPDLNSVAYQAEKLNAEQTNHFFSPETIDHKLQPETKAVIQWILNTPFVLSANLHGGALVANYPYDEARKPGNLHDYTASPDDDTFRHLARVYSGAHKTMAADKPISCGGDDFTHQGGITNGAAWYSVAGGMQDFNYLSSNDFEITLELGCDKYPPADKLKEEWNNNKQALVDFIWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYY4</accession>
    <name>A0AAV6TYY4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_023609</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000789">
        <property type="protein sequence ID" value="KAG8177292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYY4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8177292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="326" mass="34847" checksum="EEBF5C73689B2FAF" modified="2024-11-27" version="1">MDCCKNTMSKFLFALCRSPMKEACAEFLGTFFLVLCGNGVMASITLGRLGQEAAIVSAFGWGLSLGIGIWISGGISGGHLNPAVTTAMAVMRKCSWNKVVPYLVAQYLASFLAASVVFLVYHDGIVEFDLGTRQLPPLANSTAQIFATYPKDSVSTGILFADQVVGTCLLLIVICTATDSRSGRSESHLPGLIIGLGLTAIALAFGHNCGAPLNPARDFSPRLFTAIAGWGFDTFSFRNYTWFWIPIVAPHVGALVVFNVNDRLERITTESPPKSSIPPVFGSLSPTEKSLLDSNKAPEHSSVISAEGSQDFLNEALTPKESAIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0V1</accession>
    <name>A0AAV6U0V1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_023443</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000775">
        <property type="protein sequence ID" value="KAG8177538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0V1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034720">
        <property type="entry name" value="Viral_alk_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953:SF1">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01771">
        <property type="entry name" value="Viral_alk_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8177538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26943" checksum="27BD8C9E4797317D" modified="2024-11-27" version="1">MVMTCAVLHNVCVEFKVPLPDDSDDDSDSDPEVDDLLLQVVEAVISPSGFNEFAKTQLLPDICQKAEKATCLQADTPLWHELRYGRITASKLHAAAHCHTLDSSLVEQILGTRVKETEAMKRGTHLDVPVHLHIPPVPMSLNKITQVNPRRKSFKSRGTNPIKTPKLADKACSTSEFDSDPVKKNAQSQEESEDSDEASSPAETSDEEYVLPKDSENDLELDEESQRDWLKATNEKVLFAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U167</accession>
    <name>A0AAV6U167_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_025962</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000712">
        <property type="protein sequence ID" value="KAG8178197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U167"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8178197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="381" mass="43080" checksum="E4EA007CC8BFF872" modified="2024-11-27" version="1">MPLKDTTGITSILTIETRFLKLIAQHMRFSYKLMLPVDGQFGIPQPNGNWTGIIGMIQRDEADLSVAHLAMTEHRMQTIDFSESYWMEDVTFMTELPPLLPKTYFYAYPFTLGMWLAILAVMIITTFFLLPREGFGAVLMTVLRGLCRQSVNVKSAKTVSRQLLLGHWLYFANFVTMSYCAVLLSFLTVPLRQKGVETIDDLCRAVKEGSYKALVPMGSSIHYYILRSENENLHELGRTILNNHWQFDTREGIENYFAYGTALIDPIIRFTGVKFSGRFISKDSFGTSIVGVALNRRFCCKKRLNVLLRRILGAGLNQKIIEEEGFKAGLGQQNSQTEKNLKGASSVSLSIDDLYGVFAMLMAGYIAAGVVLFLELMWNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2A5</accession>
    <name>A0AAV6U2A5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000718">
        <property type="protein sequence ID" value="KAG8178082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2A5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="120" mass="14026" checksum="10CA778A53DB5C6A" modified="2024-11-27" version="1">MKGFIAFLEIFHSITLEISTEKHVSISKLPLFYGFMDDHVKMCRNEYKNRALQDVGRILSQQIADRLLKVVTINHVCEAVLLDPRFKELGLEVIKMDVTTKEKVKAKLVELLRFHYAWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2Q6</accession>
    <name>A0AAV6U2Q6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000703">
        <property type="protein sequence ID" value="KAG8178296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2Q6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="250" mass="27422" checksum="9C8BF97BB8942844" modified="2024-11-27" version="1">MSTPHKLNVTFWDMPEEEIDKPLDIKSGVKKVILEPIGRFLRPHPVRFGLSAALLLLSWLADVAGFVLPFLAVAAVHFWHATLQRGKLTPGLTHAIFCASIFGEILSAAAVDNFWLRTGIHSSVLFLTSLFVGKEPTLMLYAGCRFFLWASVPGVPDTARGLLGYACAVLGTMAAKYVEVFLMAQILPDLKLSAPRRRRSSNNTVFNVYKMRRTSLPALGGKASHHPFGYQHSHLLRLIAASVASIVGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2V7</accession>
    <name>A0AAV6U2V7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000713">
        <property type="protein sequence ID" value="KAG8178158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2V7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="13503" checksum="AE9044C29F7D5DDF" modified="2024-11-27" version="1">MSSGKCLMDEIEGTELLCSLMSILNSIAHHSKSLIINATNNIAEEFNSVITKFLGCKRIIYCLVKSFKARCNAAAVSHNTRTPLSEVLGVVKKSRAGKFVKKFERSMSHIRAAAAKRRNTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5G9</accession>
    <name>A0AAV6U5G9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000643">
        <property type="protein sequence ID" value="KAG8179200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5G9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="179" mass="19846" checksum="2EC9F53940BDE3B4" modified="2024-11-27" version="1">MGTDRHENYTISIGFSRANRGAPDTARDAVLLREQRPYPRTSRFQGHELLQRKDNSSPGHPSTSPSSVALPHLVPKDLSPCPGWGVLTPFPFGRLRDKHEHVFAFRQTSRFGTDFSDPLGPTDPCSTAVHMEPFSSFSPQGSHLSICYYHQDLHRWRLQAGSRPAPSTLATATLLLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5R5</accession>
    <name>A0AAV6U5R5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000654">
        <property type="protein sequence ID" value="KAG8178991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5R5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="25" mass="2928" checksum="FF803C4A33D098BB" modified="2024-11-27" version="1" fragment="single">MLRTGTNHREKIKVGKKYKAIKDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6E9</accession>
    <name>A0AAV6U6E9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000643">
        <property type="protein sequence ID" value="KAG8179236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6E9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="255" mass="28936" checksum="BC99C12D37F55B73" modified="2024-11-27" version="1">MLLGEKIAKSKLAPWQRIDALKTFFFPAFVFHMRTEQLSKCDMKIVDDFMRPLIKDTLYLDDSAANEYLYGSTKMGLFGIPKLADEVDIMMIDNAFKLLSSKDIRIHVLAWEDILEHITTRTGLEPSPSLIEKFLNGVQDEEGFRHTTCPYASTWSRARAASTRLGVTWRCREYGDLKLHIEGKVLTQCYRKKVCKTIKESLRTCLANNLIAKPSQGVAIEVSALHPASSSLPSKWGLHHFRRLALYSQSAAEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U705</accession>
    <name>A0AAV6U705_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_025073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000605">
        <property type="protein sequence ID" value="KAG8179740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U705"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF107">
        <property type="entry name" value="LD20793P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043596772" description="Chitin-binding type-2 domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="91"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8179740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="153" mass="17357" checksum="4877A1500212CEFD" modified="2024-11-27" version="1">MYGFLFTLLMAVLHCQIVWSQQPFKCPGQSGYFPDPEQCDLYYECRKGVAKEKLCKDGMVFQANNPNYERCDFPFMVSCGDRVYLQTPQSSKNCPRKNGIFATPKSCTVFYQCRDGLASKMNCQSGLAFNPKAGTCQWKYLVPDCGKGEETNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U763</accession>
    <name>A0AAV6U763_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000589">
        <property type="protein sequence ID" value="KAG8180045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U763"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="197" mass="22384" checksum="D1D332E936D556DB" modified="2024-11-27" version="1">MKIVPVIQEVFSKINVDACGPLPVTPSGKRYLLTAMCLSSKYPDAVPVEDITSVTVVDALLQIFSRMGFPKVLQLDQGSFFTSALSTTFLEKFGIKVVHSSVYHPQTLFALRTVTHESTGFTPAELVHGKNLRTPLTLLYEKWLDVEETEGEPVTEYVFSLINRMKRCQELAISKMEECQQKNKTWYDKRAVKREFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8G2</accession>
    <name>A0AAV6U8G2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000581">
        <property type="protein sequence ID" value="KAG8180143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8G2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="81"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8180143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="223" mass="25160" checksum="4587D07D0A938DAD" modified="2024-11-27" version="1" fragment="single">SLPEEELQLQWNGEKGGVGLLEAEDVWQSKFTLLLPIHTSHFSLQYHGPDVSGRFSCVNATFRLRRQNGYHAGYSYTITSFIVVVSWIGFYIPPTAVPARVTLGITTLLTLLTTANFVRANLPPIAYVTAMDVWVGACIVFVLFSLLLFPVAHRYATSRQNTERKVCVVLTKSDRLNHGSRGPVGNMHEPKKEIQIDVDSKCRFMFPCAFLLFNVGYWCHYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8I0</accession>
    <name>A0AAV6U8I0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000559">
        <property type="protein sequence ID" value="KAG8180555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8I0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="216" mass="24775" checksum="8106A80EF2B1C767" modified="2024-11-27" version="1">MLPTVPSKSKELVAKLVCSTEQEKCMLGNWVVCKDKYEALTSDVQNGSELISWYAWDSNSERRTVKTVKEGTLDDAINTLEEQIPSFLEHCFIKQSQSEYFQDSKKNVSEKKCLLQVDFCENFTIMQQDEVQSAHWTNDQVSIYTAVAHTITEKVTVMYVDDEEVKSQVAKLEKRWDNISALPKTHETHCVRTEGVNTVRYSMTSKTDGKVFHSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAL2</accession>
    <name>A0AAV6UAL2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_008842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JAFNEN010000519">
        <property type="protein sequence ID" value="KAG8181372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAL2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF3">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8181372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="561" mass="63927" checksum="3399BF6694DDEB1E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UB71</accession>
    <name>A0AAV6UB71_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_013026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000525">
        <property type="protein sequence ID" value="KAG8181255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UB71"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF238">
        <property type="entry name" value="SD10469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="33"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8181255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="664" mass="72262" checksum="195880D9C7A47A1A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UD42</accession>
    <name>A0AAV6UD42_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_014355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000485">
        <property type="protein sequence ID" value="KAG8181975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1035"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="907"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1238"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="907"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="939"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1244"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8181975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1309" mass="147102" checksum="DCF46734C3394C98" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHK2</accession>
    <name>A0AAV6UHK2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nephrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_002777</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000408">
        <property type="protein sequence ID" value="KAG8183709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHK2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043417336" description="Nephrin" evidence="5">
        <location>
            <begin position="22"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="644"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="141"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="249"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="349"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="446"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="539"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8183709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="775" mass="86269" checksum="12BAC0087C009C8F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJD9</accession>
    <name>A0AAV6UJD9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000377">
        <property type="protein sequence ID" value="KAG8184326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJD9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="146" mass="15767" checksum="7AF195C0BB8FAEAB" modified="2024-11-27" version="1">MFTSMPRVGSPQPAAEGGGGARVPPSHRLLPAAAARVARAVLRLRLPERGAEARALRRARAERGAAQDLVPEPARQDQEGGGGRPRTPAEGERPLRPLHLVVTPGLLLVTLVLNRLGIAVLKMHSVRDNRIHVAPRRRSFRRCASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJV6</accession>
    <name>A0AAV6UJV6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dimethylglycine dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_001519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000393">
        <property type="protein sequence ID" value="KAG8183988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJV6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="476"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="759"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8183988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="851" mass="93954" checksum="68A8037C9883772C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKX4</accession>
    <name>A0AAV6UKX4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Unconventional myosin-XV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_016213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000357">
        <property type="protein sequence ID" value="KAG8184872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKX4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13201">
        <property type="entry name" value="FERM_C_MyoXV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041795">
        <property type="entry name" value="MyoXV_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF26">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MyTH4" evidence="8">
        <location>
            <begin position="93"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="7">
        <location>
            <begin position="253"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8184872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="66977" checksum="1FCEDE86818F3096" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMA2</accession>
    <name>A0AAV6UMA2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000337">
        <property type="protein sequence ID" value="KAG8185367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMA2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="10584" checksum="453CB053DF5FBD0F" modified="2024-11-27" version="1">MLDLLKQNKYSLYCRLGKVHFREPVTKKTDQEETDQPPEKDAVKPVSQVSSDPESQKSSDHVIFPLLRDIVDDKTESSVTEQGPLTEASHTAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMG9</accession>
    <name>A0AAV6UMG9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">[histone H3]-dimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="7">1.14.11.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_008232</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60188"/>
            <dbReference type="Rhea" id="RHEA-COMP:15541"/>
            <dbReference type="Rhea" id="RHEA-COMP:15546"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.65" evidence="7"/>
    <dbReference type="EMBL" id="JAFNEN010000339">
        <property type="protein sequence ID" value="KAG8185327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMG9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140683">
        <property type="term" value="F:histone H3K9me/H3K9me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000004">
        <property type="entry name" value="Putative lysine-specific demethylase 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="10">
        <location>
            <begin position="940"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="206"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8185327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1185" mass="135155" checksum="7A789A04DED2917D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UN00</accession>
    <name>A0AAV6UN00_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000324">
        <property type="protein sequence ID" value="KAG8185797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UN00"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="85" mass="10014" checksum="2748D54FE28B7D07" modified="2024-11-27" version="1">MGIMLLKLIPKRQLQDDFKGHQRGDDLLDVCSTLSRILETEYISVFNQLLRYSYFKDNEDEDEDDVVGTHYRTPTSRPFERSRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UN48</accession>
    <name>A0AAV6UN48_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">14-3-3 protein zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_026084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000329">
        <property type="protein sequence ID" value="KAG8185620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UN48"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11310">
        <property type="entry name" value="14-3-3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="3"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="3">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00068216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8185620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="245" mass="27944" checksum="CD2733001D0957D1" modified="2024-11-27" version="1">MDKDELVQRAKLAEQAERYDDMASAMKQVTETGVELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTEGSEKKQQMAKEYREKVEKELREICYDVLGLLDNFLIPKASNAESKVFYLKMKGDYYRYLAEVATGDQKNSVVEESQKAYQEAFDISKSKMQPTHPIRLGLALNFSVFYFEILNSPDKACQLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDTQGDGEEQPEAGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNB5</accession>
    <name>A0AAV6UNB5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_023868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000341">
        <property type="protein sequence ID" value="KAG8185253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNB5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8185253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="561" mass="65045" checksum="BF094E0108379CC1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ03</accession>
    <name>A0AAV6UQ03_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_000700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000325">
        <property type="protein sequence ID" value="KAG8185711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ03"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="50"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8185711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="343" mass="37833" checksum="4C1CEE50BE5494AB" modified="2024-11-27" version="1">MDPEPSGFERMKQSGYSTVVQVEENGPKSNKKVLLQSAESIGSAILYGVCSTSMAFTNKAILTSYKFHFPFFIMACQMILCVIFLEILRITQLSNIPKYSLKSGKSFAWPSIFYALHSVTALHALGGMSIPMYAAIKRCAPIVTLILSVLLLKKRVPNARIVSSVILISVGCVVASLGDLEFDSKAYKYGAVSILVQGLYLTLAQKCLEVMPALQVLHISSYNTTPFYVILCLLMETEGISHYKYFSDIKFLLCFGVQVSIGVLLNYSLFLCTEKNSALTTSLVGVLKSIMQTVIGFFAFGGVQFSALNVFGISLNMFGGILYSYSKYMEKFKVNPESFMKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URF5</accession>
    <name>A0AAV6URF5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_023784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000286">
        <property type="protein sequence ID" value="KAG8186897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URF5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000182">
        <property type="entry name" value="Paired like homeobox 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="110"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="112"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8186897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="308" mass="33338" checksum="AA806A4E0659DF0B" modified="2024-11-27" version="1">MDYPYLNQPPFDPSCSLGTMELPSCQLPCSYADLGSCSQMTSAYRYSTAAVPRSFGGPSAVGPPPCGMVAARPRHDQGPASVFSSAGMALQSGLPYKVYTGHDGVLTEKRKQRRIRTTFTSSQLKELERAFQETHYPDIYTREEIAMKTDLTEARVQVWFQNRRAKFRKQERLNQQKQAQQNNSSSQANSTTTSTSSTSNCTDSTASSIKDGKDTKPPVLSTINADSKTVNAPSYPNMAMSWCVSGKISPSVKWSTGHCPQQKPAVAAISPLTSLASSCPTSSFPGVLGSVPYPLSSIDTKPALASMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USK8</accession>
    <name>A0AAV6USK8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_011669</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000274">
        <property type="protein sequence ID" value="KAG8187296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USK8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="11" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="335"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="434"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="467"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="532"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="599"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="666"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8187296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="835" mass="92418" checksum="3C30209915A3ED65" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USM2</accession>
    <name>A0AAV6USM2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tight junction protein ZO-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_009802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000292">
        <property type="protein sequence ID" value="KAG8186733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USM2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150105">
        <property type="term" value="P:protein localization to cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PDZ3_ZO1-like_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11859">
        <property type="entry name" value="SH3_ZO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13865:SF28">
        <property type="entry name" value="POLYCHAETOID, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13865">
        <property type="entry name" value="TIGHT JUNCTION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="140"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="225"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="405"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="7">
        <location>
            <begin position="997"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="540"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="761"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="803"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8186733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1129" mass="127177" checksum="CCD3612737C5BCA5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTE4</accession>
    <name>A0AAV6UTE4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_015624</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000261">
        <property type="protein sequence ID" value="KAG8187755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTE4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000845">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050609">
        <property type="entry name" value="Antp_homeobox_Deformed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771">
        <property type="entry name" value="HOMEOTIC PROTEIN DEFORMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771:SF6">
        <property type="entry name" value="HOMEOTIC PROTEIN SEX COMBS REDUCED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8187755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="104" mass="12939" checksum="64FDA7B5F24DFE1A" modified="2024-11-27" version="1">MGETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKEHKLASTMPPQIPQVMADHHHPHHPHHHHHAHHLHGSTNVYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXE5</accession>
    <name>A0AAV6UXE5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_029067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000248">
        <property type="protein sequence ID" value="KAG8188141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXE5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8188141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="415" mass="46696" checksum="8922A82941E32643" modified="2024-11-27" version="1">MDTSGSSVDDQDIVNLCKELLLWKPTRCRGRFWCLSPETWLAFGFFLMVMGLSLLSTGCFFTSDADKKQVIKFGFFALLLGTTILIMLIGRVNDGTYCRLLCAHTSPPKFVGVCISPPIQPEFLSAMLLPEINREWVPVETLPGFERCHADIVPPPTQQATAGDENGEESRSKKRRNRKKKVNNSFSELDPASQESNEIIARVDANQEDVQLRNGDPPSKIKKQDFNKLNEDSDQQSLQENSQPAKLNPDGYNLNKSISQEKDKQMRNQKQAGNHQSSSRLYDSIYKNNSSTRNKVLEENSSDYNHKDSLQTASRLISKGKSDKPAVNFITDEQQKKSELALLSPDQNYANNSFEQLNITSGHLGNNTKEKSEKSADKTSSSNTTSTEMQQVDPKPVSPDFITSTSKKRNRRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UY54</accession>
    <name>A0AAV6UY54_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UY54"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="9007" checksum="E238E53145D53236" modified="2024-11-27" version="1">MGKGGTKNKEKRTPGKTKRKKKRIKKQEKRKQPKQDMEKTWEGFQLRSSDVMSMYLQQLRERFSEAAPEKEEKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYN7</accession>
    <name>A0AAV6UYN7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000213">
        <property type="protein sequence ID" value="KAG8189537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYN7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="420" mass="48704" checksum="D75AA523BDA9652C" modified="2024-11-27" version="1">MAAEHSNSNYSLLDLPDLVLYNICAELTCPFDLLSLGNTCSRLRRISSTPSSWWKLAFRWLRGLWVLMEEGSIEVNARDWMLDIMRQYCAKATRTKPEVVFNGGETWRRVDSPKFRFLFNLMRVAYTKDREDNPAVLYEQWLYDMGLYQRTSLCVEYTRHDFDFSQDEVVQLSTLGQASERDLCRRKQPFKDPKWYLKRIGVSGQPWMEELFPVSLNGSICPLLMCPFLNSCHREVSGPQGLAICFSRVFEQRLMHTCKSSSLPLYNVWELIKVATSVFMSEILFVLRSFESRLADLSLKGAFCAIVMENIHNFPQVQMIFEKMELSFTAMDVCRDLILLLNEYKEIDFVVDDVRLVLRRAINEEINKVLFPSCSLVTRINLTDSDLIGGDNSKHEMSSAAFVSDHGVLVTWHLTGRMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V061</accession>
    <name>A0AAV6V061_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000197">
        <property type="protein sequence ID" value="KAG8189996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V061"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="124" mass="13843" checksum="2F29D0C9986AA17D" modified="2024-11-27" version="1">MISSVSRPRVLYNPSIIFPTLYCGALCPPWAHPTSQSEASISEIWVWHSSYEDYHTTLRRDHDDLHGVIAKLVVCRRTLDFATHGEIAGPCVCHPALPLSSPDLSFRILGMLLPNADVRDLCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0F8</accession>
    <name>A0AAV6V0F8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCNA-associated factor histone-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_019013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000224">
        <property type="protein sequence ID" value="KAG8189001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0F8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031444">
        <property type="entry name" value="PCNA-AF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15715">
        <property type="entry name" value="PAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA-associated factor histone-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8189001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="149" mass="16321" checksum="8AFA8F96899502DE" modified="2024-11-27" version="1">MARTKADAAKKAGGKAPRKEPMLRNSPSSAGVSKSKNCNGAALRNSARKCPVPKWQVSVKDLAWMQPGSSRDPQAQEVNEENGNNHEENGGKSEENGREDEGSELLQQDMEDSNESVDQELDRSESLGRESLDIEISNHDKVDDSKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4I3</accession>
    <name>A0AAV6V4I3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_010841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000169">
        <property type="protein sequence ID" value="KAG8190982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4I3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="94"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="475"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8190982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="632" mass="69662" checksum="12B97C2AB58238C6" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4I6</accession>
    <name>A0AAV6V4I6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000155">
        <property type="protein sequence ID" value="KAG8191635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4I6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="207" mass="23832" checksum="3780BAEA8AEBD498" modified="2024-11-27" version="1">MLVIPQEVRWNTYFDTIKSYLDNRGKLVQVCQDHQNEIGKDIFKLVNDVNLTVNCADYLAVLKPIAKALDSMQSDNTKLAESVDFWNKLGETLESCSASDQTKVMKYFNARRGAHYAANLLDHRYCGKTLCDAQRKKVLFISCNQSEILPLAMQFLAKRAPFPSYMFESQFNDVDPITWWANIELTPRQRLSIFHKNCSLDPLLQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5F4</accession>
    <name>A0AAV6V5F4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5F4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="230" mass="25208" checksum="966600EE84681C12" modified="2024-11-27" version="1">MDEKGNNSSCSSSVCPKNIPPQKPLSSLATLPHLPFPFRLDRSSPGIPPSSQVQRPPTVNIEPALRRLPEDRDTSLELTSSYFTGLFQSTSQPSDQTSIQSTMDVFSELDIHSPVTSSVISSSDLVATVESALQFAEASSNHDFSMDFFSDYHRTNKDGYEGDSRYEFLPPYPEGASPSSTSSMSSSMYQPPPSPYSTPPSTFSMIQEGSKKREGQKRLASTGELLFLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V729</accession>
    <name>A0AAV6V729_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">sn-1-specific diacylglycerol lipase ABHD11</fullName>
            <ecNumber evidence="3">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha/beta hydrolase domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_019602</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48596"/>
            <dbReference type="ChEBI" id="CHEBI:11152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:90605"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77107"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:77129"/>
            <dbReference type="ChEBI" id="CHEBI:186738"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75468"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38503"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:77272"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000158">
        <property type="protein sequence ID" value="KAG8191538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V729"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="42"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8191538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="147" mass="16849" checksum="FE487A203DAB50FF" modified="2024-11-27" version="1">MVATRTCDIYISQNSSYNKMENAVKLSYDAIESNGTRPDLCPVIMMHGLFWNKFMLKDLAIKLNQMTQRKVFTLDLRNHGESPCPKDCGAVLMAEDVKLFIDDMNLKRVSFVCHSFSSTIAYLVGLDRVRLLLSFTTFNQKAEEKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7N5</accession>
    <name>A0AAV6V7N5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000154">
        <property type="protein sequence ID" value="KAG8191656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7N5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12633" checksum="041B45993F4C91F9" modified="2024-11-27" version="1">MVKENDNILEFKNYQYQLSIPFVIFADFETILRNENIANPSTSSVTEKINQHEVCGYSYVIVGPDGKSVKPVVVYRGVNAVDRFLEDILTEEKELVKINYYSSIVYDSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V958</accession>
    <name>A0AAV6V958_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000132">
        <property type="protein sequence ID" value="KAG8193012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V958"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="10082" checksum="9CDAFDBC7DBC3068" modified="2024-11-27" version="1">MCRHDSRGTKMLPYLSPSDSSTHTLVTSDQPRLCHTIHLPSNRAESSHNSKNKTRYSSWYAEFLAYRKIIARCDLAITMCSVEIQISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9I0</accession>
    <name>A0AAV6V9I0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000135">
        <property type="protein sequence ID" value="KAG8192773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9I0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11102" checksum="8A17BE1F1E4BCEC1" modified="2024-11-27" version="1">MDKVDSENGAGSELLEAAGRWSTPYTPGVILRACAQGGAVIVVPMLSDYLQNGWYGVVHDASSFQDSLAEWMKDKPLSILQLDPADRAVLRIAGESLLLFYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9X8</accession>
    <name>A0AAV6V9X8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000121">
        <property type="protein sequence ID" value="KAG8193437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9X8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="107" mass="12361" checksum="56A846AF8FF1C476" modified="2024-11-27" version="1">MNIDNFFKWVEEKLIHNIPPNSVICTENASYHTKVLDPVPSKYSTKKKLIEWLVEKNIVHNPNTRKTELYDLVQANAPPAKKYYIDELFKTNGHDVLRIPPSGVGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VA19</accession>
    <name>A0AAV6VA19_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable arginine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_028077</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of arginine to tRNA(Arg) in a two-step reaction: arginine is first activated by ATP to form Arg-AMP and then transferred to the acceptor end of tRNA(Arg).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000132">
        <property type="protein sequence ID" value="KAG8192953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VA19"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="12">
        <location>
            <begin position="470"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8192953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="593" mass="68189" checksum="91750689C48DB387" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VD48</accession>
    <name>A0AAV6VD48_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000113">
        <property type="protein sequence ID" value="KAG8193858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VD48"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="11937" checksum="C1D477804023E0E8" modified="2024-11-27" version="1">MHCHCRPPPLKHIDFRLTNNGALIAYTSPHDSLQLFFCLQLAPLPTTPCVTENGAFIASPLQLSATFIYLFFYLFFFVIGFFATWFAPSPRKKRFSCCSDLALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDG7</accession>
    <name>A0AAV6VDG7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma-glutamylcyclotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_026370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000099">
        <property type="protein sequence ID" value="KAG8194719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDG7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061929">
        <property type="term" value="F:gamma-glutamylaminecyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039126">
        <property type="entry name" value="GGACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLAMINECYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510">
        <property type="entry name" value="TROPONIN C-AKIN-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639126-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8194719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="171" mass="19661" checksum="116403EF2C46AD96" modified="2024-11-27" version="1">MTSSFEGGNKSEECEHLIFTYGTLKRGEPNHGIITDSGQATFVGLARTIQKWPMVIASRYNIPYLLYSEGVGKNVIGEVYRVNNIMLSHMDELECHPKYYTRIKAEVEIIRDNINVQQSSSLILRPWIYFLQNFRPHLLDLPHLENYESKGAHGLEYVSSEETCDPEDIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDJ4</accession>
    <name>A0AAV6VDJ4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000110">
        <property type="protein sequence ID" value="KAG8194038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDJ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="383" mass="41596" checksum="17C7F17C5ADF7F47" modified="2024-11-27" version="1">MLVDLVRNTIVQIRPAQSAWRDPARSVGVARSGPLGRRGEIGRRSAWRDPARSVGVTRSGPLSRRGERPAQSRRDRPLVDVARSGPLGRRGVIRPLGRVARSGPLGRRGEIRPLGRRGEIRPARSAWRDPAARSAWRDPAALVGVARSGPLVGVARSGPLSPANRVSAGEIRSNPLGRRGEIRPAQSAWRDPTRSVGVARSGPLSRRGEIRPAQSTWRDPAAQSAWRDPARSVGVARSDSLSRRGEIRPAQSAWRDPARSVGVARSGPLSRRGEIRPAQSAWRDPAAQSAWRDPARSVGVARSGASGLTWVQSVRSDVTERATLAGTASARSQKVTHDMATMRVEGAYVFTMLPVSRRTSGNTATSMVKLPARRWKEKQKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEF2</accession>
    <name>A0AAV6VEF2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Brain-specific angiogenesis inhibitor 1-associated protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_003029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000109">
        <property type="protein sequence ID" value="KAG8194086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEF2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027681">
        <property type="entry name" value="IRSp53/IRTKS/Pinkbar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206">
        <property type="entry name" value="BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206:SF7">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 53 KDA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="IMD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="312"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8194086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55796" checksum="91B59D99E12C7C37" modified="2024-11-27" version="1">MKQLVAAGRTYLKSLHTMMSASRQYTEALTKIASLANNSTLSGSRDIGSTLFNIVDVNKELLAQQSNIVKSLEFDFLEPMEIAAEKDTKLIGREQKRFQQLYKGRREAYLKCVTTLKKTRRKKNINTDKQLAHMKMLESAKERLEVFCNDSLKEAIIQERVMYGTVLERQCALNRQFLIYHAKGCEILEEQLPYWENIAETRDKLPESCFTAVKNGHQSFPMTMDGIYSLDSMLDVVIRNNSIARSYGKNDRDSVLSSQTMRVPNKEDNIYARPIVRAKSEFCLPTSTSDDSPKADPNQKRFSRVVDYHEDGDTSYARVLYAYEPTGDHQLGLREGDVVEYITEENTTGWQFGDNLTSGRSGWFPVSYTEPIPEPNRNVYTEAYEEKSLPPPPLPPVSKEPIRSKYSNPQQQVSGEYATLTRAKKLLPTNSANVSYAGDLPIENGGTLKANRSKHYASHPNIYEGSSATLGRTTNGVSSGTVYNNGMYLPSMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEM0</accession>
    <name>A0AAV6VEM0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000103">
        <property type="protein sequence ID" value="KAG8194443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEM0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="248" mass="27782" checksum="5F7E57E5EE0783D0" modified="2024-11-27" version="1">MLLTGTDINPSIKEDESKKEMEFKKRAMEESGSEESEEGDGTAALGPLQCSSIKIGSYTVVPQPNKPYVDVILNVHNLTFDAPLQSDPSKQVRIKLGSADILKMYVHFGRGLLVMFIDITQEFGELLRNALHMIENGTLNSDPSTKDDKTHLTLTFIIQCMTEDQMRFIRSKFPCKKCYNEIIEIDQKTANGILVNSTHNQVLEKLPDSFAVRVPDAPSEPMEQHHTGEDITRISEGKQHCSCVNPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIC2</accession>
    <name>A0AAV6VIC2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_003562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000068">
        <property type="protein sequence ID" value="KAG8196545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIC2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF4">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="598"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="470"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8196545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="742" mass="84890" checksum="A0EF81C2996CC8DB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJ32</accession>
    <name>A0AAV6VJ32_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_012311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000069">
        <property type="protein sequence ID" value="KAG8196495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJ32"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="112"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8196495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="410" mass="47544" checksum="C92FC45EFD8963EF" modified="2024-11-27" version="1">MPYMKCEPLKWRKNAKTVQNERALRNENKERKNSDVTRGTAYSRFCERISFVKYIFLILIIPPVLNYASLKRESAILMPLEGEQVDMGWGQKMFIHCLGEGVPTIILDAPTGGTSDIWFFVQQHLSKFSKVCVYDRAGLGYSDLPFVNEMRTPDKAENRKFVSQVATLEQMTCDLHHLVTNGKPLPRPFILVGSETGGLIARHYALTYPSDVSDIVLLNPFVEDLFRRQSEDWNNHWNMDVLPYLQSLQLFAYSGFPRIFALLGYLKPQLFGDDVPQEVEMRQLSHLCNPSHMSAVFHEHLLLNTSFMQMDEVWQAKPFPKNVSVTVINSRKFEKIPTILQKAWQQSQLHLRQFLHPTSKHFLFDGSFSQLYVEPATITNTVQQLVYKWRISHDVLPTVHTFREQETLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VK94</accession>
    <name>A0AAV6VK94_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000058">
        <property type="protein sequence ID" value="KAG8197217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VK94"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="115" mass="12104" checksum="20F898A581553813" modified="2024-11-27" version="1">MDVEGKGDVEDPAMEAEAVEDPAMEAEAVEDPAMDVEGKGDVEDPAMEAQAVEDPAMEAEAVEDPAMEAEAVEDPAMEAEAVEDAAGFLFLLIGKTVVAYSDQFLLATIAKNLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLA5</accession>
    <name>A0AAV6VLA5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_007211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000054">
        <property type="protein sequence ID" value="KAG8197467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLA5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019346">
        <property type="entry name" value="Ribosomal_mL42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13450:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13450">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10210">
        <property type="entry name" value="MRP-S32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8197467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="134" mass="15827" checksum="96C1019FCD10B8B6" modified="2024-11-27" version="1">MSVIGKCGLVKFSRFLCESLLKQMPVTSHIYYSSTKNRNSWTVLSNDGQTICCWHPKENVPYEHTRPLPVIDPEFNEDDSVLKVQYRRHAKHRFQPDGPTIPELAKLTYTTKHRWYPNKEKKYEDPQQFDRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLC8</accession>
    <name>A0AAV6VLC8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000065">
        <property type="protein sequence ID" value="KAG8196704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLC8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="129" mass="14402" checksum="2178441964AD80A2" modified="2024-11-27" version="1">MCQDSWGSEVETVNNKMLLLVQEEFQSNCQDLGSTARIDFQSSTAVLGVGGVLFWCGREPSTLRDQRYKIELAGIGLSPRRWADTRGGCPRHRVHSILSSRMMGGRLELEGCDTIQIMREVPRSLVCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLJ0</accession>
    <name>A0AAV6VLJ0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000056">
        <property type="protein sequence ID" value="KAG8197350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLJ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="157" mass="18275" checksum="7CD64FACA3E9B027" modified="2024-11-27" version="1">MFRGRIHPMISHDIIFSANSFTWSCVIRDFIRMWQPILGGDWSTVSVYYNPTVTSRSSRSTSVTNPTSSPSHFFSRCCCWGFYGHEDEPAYEPKVDDSAAVPDEEETRQPPKTDDWKAKVNHTFVVQKRFSQMKEEVPELDWDRLFIIWAKATLTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMX9</accession>
    <name>A0AAV6VMX9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Noggin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_011322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the noggin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000058">
        <property type="protein sequence ID" value="KAG8197162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMX9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.520">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008717">
        <property type="entry name" value="Noggin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10494">
        <property type="entry name" value="BONE MORPHOGENETIC PROTEIN INHIBITOR, NOGGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10494:SF6">
        <property type="entry name" value="NOGGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05806">
        <property type="entry name" value="Noggin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8197162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36794" checksum="2343BEF84376E75B" modified="2024-11-27" version="1">MFEGVCVVRRRSSVSVGVVKRIRGLFFLICYCLGRSVVAPSCVDRWGPESRLRVGPTLHESLILIFSLFLHQSIPPSSHRILGGENFLQSGQPLARKMDHPSPSFCIFILLLLLPYNEGRRPDPSSVLPVLDLLEPRGDLYDPRPEDTDEARLRSILGRSFDPKVMSIRQPTAFLTHPNGTVQLGLRKTWSGGMVPLGVPPKFIKRLKLQGVRMGDGKRIDIKMGNKMRRRFRDLLWLQSHCPLLQKWKDLGPRFWPRWFLENSCALRATCSFPRGMVCRPHKSLNKILLRWHCQNWESKKNCNWLRVQYPLVTECQCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VN98</accession>
    <name>A0AAV6VN98_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_004305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000059">
        <property type="protein sequence ID" value="KAG8197036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VN98"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF1">
        <property type="entry name" value="RE15579P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043888149" evidence="3">
        <location>
            <begin position="26"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="613"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="212"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="5">
        <location>
            <begin position="297"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8197036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="670" mass="74331" checksum="D6AD9FFCB915926D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VND2</accession>
    <name>A0AAV6VND2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aprataxin and PNK-like factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_006925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000043">
        <property type="protein sequence ID" value="KAG8198179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VND2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039253">
        <property type="entry name" value="APLF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019406">
        <property type="entry name" value="APLF_PBZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21315:SF2">
        <property type="entry name" value="APRATAXIN AND PNK-LIKE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21315">
        <property type="entry name" value="APRATAXIN AND PNK-LIKE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10283">
        <property type="entry name" value="zf-CCHH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="PBZ-type" evidence="3">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="PBZ-type" evidence="3">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
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        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
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        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
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        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
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        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8198179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="68350" checksum="BE285B134345FF79" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNJ8</accession>
    <name>A0AAV6VNJ8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_006892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000043">
        <property type="protein sequence ID" value="KAG8198139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNJ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8198139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="282" mass="31833" checksum="38053B48648C9172" modified="2024-11-27" version="1">MNSRFTRCNPAVNPLSIDTRAMFLFIFLLAVSSECGAQLYMYGGPMSYRRAPIKRSPMEALERLRAPAARYYPQMDYLEEGANSVYALPPQWTDTAALYNEEQPMNDEDEYDYQASVVRPVYQGPVETYPEPEPELPSDVMSYNDLMNGYYMNAPPPEMPLWMERRSEKTATATTTTTAASTTATSQTGSAPTYQPEKKSVQSMVLPDPARQSSAPSGDEGQKEVPLFRPLHNSQRSTEWTNEQQKSAIPMLKQMIQGLQKQQQQKKSTDPLLEELNSLKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRH2</accession>
    <name>A0AAV6VRH2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000030">
        <property type="protein sequence ID" value="KAG8199215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRH2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7824" checksum="55322E377144BE50" modified="2024-11-27" version="1">MQGGQSGHSQMLSGLMRSLTGKLDRERFSLSSLTLHHSMLLRVALLGSWQKNPSWSSLWFELTFELSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS42</accession>
    <name>A0AAV6VS42_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tetratricopeptide repeat protein 21B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_026543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000219">
        <property type="entry name" value="Tetratricopeptide repeat domain 21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056832">
        <property type="entry name" value="ARM_TT21_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056836">
        <property type="entry name" value="ARM_TT21_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056835">
        <property type="entry name" value="ARM_TT21_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056834">
        <property type="entry name" value="ARM_TT21_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056833">
        <property type="entry name" value="ARM_TT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040364">
        <property type="entry name" value="TTC21A/TTC21B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699">
        <property type="entry name" value="STI2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 21 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25058">
        <property type="entry name" value="ARM_TT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25060">
        <property type="entry name" value="ARM_TT21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25068">
        <property type="entry name" value="ARM_TT21_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25064">
        <property type="entry name" value="ARM_TT21_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25063">
        <property type="entry name" value="ARM_TT21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25062">
        <property type="entry name" value="ARM_TT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B N-terminal ARM repeat" evidence="6">
        <location>
            <begin position="13"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B second ARM" evidence="5">
        <location>
            <begin position="265"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fourth ARM" evidence="9">
        <location>
            <begin position="725"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fifth ARM repeats" evidence="8">
        <location>
            <begin position="921"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B C-terminal ARM" evidence="7">
        <location>
            <begin position="1069"/>
            <end position="1278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8198647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1283" mass="145940" checksum="82126B1899AFAD64" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS64</accession>
    <name>A0AAV6VS64_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">JTE90_009385</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VS64"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF40">
        <property type="entry name" value="INNEXIN SHAKING-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8199544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="360" mass="41956" checksum="ADE6B207B945AECE" modified="2024-11-27" version="1">MSIMIHALSTLKGLIKSKKLHIDHWAFRLHYRATVLILFLSCVLVSTKQYAGEPIKCSSGITQESSLIDTYCFVTTTYIVKKALNLTPSEGAPHPGIYPSQNPEDFRQITYYQWLVFILLIQAIFFYFPHWLWKMWEDGEISSLLERDQKFLPKEEQVKVRDIIVEHLRCKWSKSSSYFGKYLVCELLCLANLFGQIALLDAVFFNEYLYYGFEVLAYFNSSPGSMVSPFLRIFPKVTSCIYRYFGSSGKLESQSFLCVLAVNVINEKIFLLLWFWFVFLAFFTIFMLVFKVALFTISSFRISVLSYRFPSTRRDDLQLVIETGNLSNFLFLYLLGENMNESSFSEVMEYFSTVQRGKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSB9</accession>
    <name>A0AAV6VSB9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase substrate phosphoprotein PP28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_009419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSB9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="89"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8199582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="189" mass="21584" checksum="AB08A7766A64B4EF" modified="2024-11-27" version="1">MPKPRGRGGSGHKGLRRHFTNPDQMAQNEEKKEKERQWRQQRGELSSSEESGEEKESSSEESSSEEEEGETEEKQSKAKGVQHLIEIENPNRVVKKEKKVETIKVDEVSSAQLSRREREEIDKQRAKVHYQKMHAAGKTNEAKADLARLAIIKKQREDAAKRREEEIKAKAEADKAKAAETKKALGRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSJ3</accession>
    <name>A0AAV6VSJ3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_021041</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000032">
        <property type="protein sequence ID" value="KAG8199026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSJ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02952">
        <property type="entry name" value="TRP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000124">
        <property type="entry name" value="Thioredoxin domain-containing 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8199026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="123" mass="14016" checksum="5B4615DCBF8F7395" modified="2024-11-27" version="1">MVKRINVEGFDAVQKAIRENSKSDSLFVLFSGAKNSRGESWCPDCVAAEPIIEEGLKIAPESSVFIYCSVGDRNYWKNPNNEFRKDEKFKLTSVPTLMKWNTARRLDDEQCKSAALVTMLFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTX1</accession>
    <name>A0AAV6VTX1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_001958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000020">
        <property type="protein sequence ID" value="KAG8200104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057618">
        <property type="entry name" value="Znf_POGZ/Z280C-D-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25429">
        <property type="entry name" value="zf-POGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1551"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1685"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1562"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1581"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1632"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1695"/>
            <end position="1707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8200104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1861" mass="208997" checksum="8B3FE689AFAD4F80" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXH9</accession>
    <name>A0AAV6VXH9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000013">
        <property type="protein sequence ID" value="KAG8200798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXH9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="81"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="172" mass="20049" checksum="C8277383CCF0633D" modified="2024-11-27" version="1">MLIGSLKRILRRVIGNACLQAEELSTVLCEAESLINSRPMTYISEDVDDLKVLSPSMFLNEIEEFGVADFEEIDAKRMNSRFAYRLRLRNDLRKRFRNEYLRQLREYYKVKGDQHVKEGDVVLIGDTNCKRLSWPLARISKLLPGRDGNVRLVQVKTSYGTLLRPIQRIYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXW9</accession>
    <name>A0AAV6VXW9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXW9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="136" mass="15258" checksum="CAB95BDE928AE3E0" modified="2024-11-27" version="1">MLHVYPGGDDTIYVNGRSGIGEWQAANRYGAQERDCYLIEGLCTYGEINCVRAVFSICCEGRQRQNEKMIKVGPKLGENILMLDLVNIIVDIWTLHMGDLNLGHANCCMYKNDSPSHLCCTTIYLPTSRNNPLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYW2</accession>
    <name>A0AAV6VYW2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_027305</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYW2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF349">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE BRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8201825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="256" mass="30385" checksum="1A449FFDC812305C" modified="2024-11-27" version="1">MLGISSDKSIQNQIDEEHARNKDLVQAEFMDTYYNNTIKMIMGFKWVVEHCPKAQFIMFSDDDMYISTKNLLKFIRNPFNKRVGFRRRRDVDKMMRHNYHYKRELPNSDSVDSSNERRLMEFDPVLSAFDGRLFSGFVFQSSPMRHKSSKWYVTLEEYPYSKYPPYVTAGAYVLSYPALEDLYFTSMFTKHFKFDDVYLGIVAKKCGISPLHNDNFYFWKKPYSKETYSNVIASHGFSDPNELREVWEEQRSLGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZL0</accession>
    <name>A0AAV6VZL0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZL0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9921" checksum="48F906F6FB0A34A6" modified="2024-11-27" version="1">MQEQQDYSGYHKVIGPNRPAPLENDDSRHSWSTRGSNTPPARTRTQRLERRLSREARPGLPFYLLGGKRAKWHFPSPRKRAKGPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W2P3</accession>
    <name>A0AAV6W2P3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_027351</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W2P3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8201872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="409" mass="47531" checksum="AE11247D84A7DB14" modified="2024-11-27" version="1">MIPSRLRVSLIPDTYFTLVNESLPGYQRVSGAFGEFLNIIAKHLGFEYDFVYPEEFNIGVRKDDGNWTGIIGILSRGEADLSLNHLSMEFHRQEVVDFGTVYAAEEVIYFIEKPNYEEIPIFGFLYPFDFTVWLCFAVTVLFIATFLYFISQKRLEYGDTLLTLLASVLKQPLKINCYQNKEHLIFLFWLFFALVISVAYSAKLLSFLTIPLKKPQIQTFEELYSAVEKETHQCFYYENGYVMGELKQSKTKYLNNLRNAIIRNSWYLDGSDYPYLNLVTENLGIIYTQLEYSLFFTAFGSKSRYMRFEESLGVWPIAVAYRKDFCCKTEINEVISRIVSSGIVDKLFSDVSFKFWAANAKDIVEREKIIAKLRVEDITGPLLLLVTGYVLAILVLICEVIYYKTFRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEW3</accession>
    <name>A0AAV6TEW3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005679">
        <property type="protein sequence ID" value="KAG8163804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEW3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8163804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19142" checksum="472F252B28A1CF03" modified="2024-11-27" version="1">MERGGPGAPPPRGNGGSRMRPTSPGLIFISPPGYSTLARAHVRLLGPCFKTGGEKAFPPSRDPHHKRGPLYLILPQKYCHKIKYETTSHSRQTVLDSPRPALHIAAGRGNNKGRKGRQASRVGHAHGIQLTPTRSPMLRSQYAPYSHRNNFRDGAARHGAGPLAEKLRREGSRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TG55</accession>
    <name>A0AAV6TG55_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005159">
        <property type="protein sequence ID" value="KAG8170598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TG55"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="66" mass="7543" checksum="2F5FE25688BB8953" modified="2024-11-27" version="1">MGSHERLASDALKPGVWFIPQRQFCLPKVGPLGTLILSRPAFSHARRTSHPFKFENRLRSFRPQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGK6</accession>
    <name>A0AAV6TGK6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004722">
        <property type="protein sequence ID" value="KAG8170882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGK6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="177" mass="19523" checksum="EF78CE6982DED531" modified="2024-11-27" version="1">MRRPPPACIHFAAGYSRPMTAQIGIIARASVEREGPNQRRDEDYALLEIPRSADNCNRQSPARKRFNGLPIPVGEGKSNTMILQCGSGGPGHLGHLQTDYCLCPRRLNAASPSKKKRRLGMIRGLFSRLSKSLVRYQNKPDNSLPEPKSGNAPLPRNQKSSYNLFNLAVSWPVGVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGV3</accession>
    <name>A0AAV6TGV3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004516">
        <property type="protein sequence ID" value="KAG8171054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGV3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="483" mass="55306" checksum="DDBD321EE57AF08C" modified="2024-11-27" version="1">MDPVDIFPVLTIPFRGQPECIQKDRSTWKETLLPKIESYIHVQFKDDRVFAFPAPRLDAKRQADHFRRCVDDAQTQRLIGKRDITWNKVVKTLKRDPNSALKNTSIRHFYKVEGHMFLVKFGFTFGLCFVEPGTQHVYQLSSVPLLCFHLPTTHHDRKTFATLTRRIFLASDQKYYISSTFHPHQKYVVPSGTKYLILATQKTIFSVQVIPDTIQLSPSEFFSFTTHKEQTHVYNIPPPTPRHPGSGSVSSCRSNDAPKQKHDWKKYIIPKRTTKAPNVSRNYPPTIGCSDSQTLTTRTNEFDIKANGPPENTLTLRSELNSMLMEIQSWAETQPTLMDLESTTTVLTQTIEPQTKNLSSSQECLDFEEEMAFLDQPYCWPSHTPTDPIVHTSQVTSTTEPNLETLNTKPSWPFKTLYVNCPWSMKPQELVPPSLLSQKPDRDIGPAHGEEVSHRDHLTHVLGNTYRIAESDGTEHPLDLMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGZ2</accession>
    <name>A0AAV6TGZ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004645">
        <property type="protein sequence ID" value="KAG8170950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGZ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="260" mass="30438" checksum="BC72BF6A27F66C94" modified="2024-11-27" version="1">MSKRMALVPEELFSSYQFRDPETRIEDEMTKLLDRNTLPDDMKVKLLSQLITRYHKVVNEPAEPIPVKMQETNVPIPVKMQEVKEPSKKDETHPVDSMVRNILMSVPKYSAKFITPIIEKLKTRGVSWNEKGEITMDGRVITNSNIIDFFSYLMRNSKEQLEPRHFDLFLKAIKEAKIPMSWITNKRLYNRLNEAEDSFVFESVEDEPPSSEGRRFTPLRRKKVKRSYRDLSFASPSPLAAWHRNPNEKWLNFSGKSTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THY0</accession>
    <name>A0AAV6THY0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003879">
        <property type="protein sequence ID" value="KAG8171510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THY0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33626:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33626">
        <property type="entry name" value="ZGC:158463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="108" mass="12911" checksum="EE1A8046F28A523A" modified="2024-11-27" version="1">MGNPLNLFRAGDWRLQLSAMNEEFLVSVSHHLALIRSLALVHTARRYYRLNILVRTSDWLSIWLSGRADVPKKMPELDYLEEIKVVTRYPSVNQRVDHYRTFRREREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TI65</accession>
    <name>A0AAV6TI65_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004010">
        <property type="protein sequence ID" value="KAG8171412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TI65"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="153" mass="17702" checksum="63922EF1673C3EFA" modified="2024-11-27" version="1">MYDFVAVAEFLFLQGVLVPFRVIFTSTRNPDKTILLEADTDTLQMTYADVRKNLQMSPHLFTQQRPTTHHLTFHVKHLSFYLGGKFTQDYLKEAWHEPRIVCLDSATHNLLLGLMPNVTLLDGQLRQNNSLDLSLRAARLLNTKLGLEPYWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TID0</accession>
    <name>A0AAV6TID0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004010">
        <property type="protein sequence ID" value="KAG8171411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TID0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043989311" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10070" checksum="0BB7DDB3A63F393A" modified="2024-11-27" version="1">MKSGARNGLTLHFFWVSCVANVDSNGAANHCELLYNCLSIQEQFPCPTLEMICSTTVALVKASIQMHANAWLVHSNQLKGVSRNKVFFRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIM1</accession>
    <name>A0AAV6TIM1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003881">
        <property type="protein sequence ID" value="KAG8171508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIM1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="102" mass="11406" checksum="E3070A4BD1F7DA53" modified="2024-11-27" version="1">MSSAETLHFPSKGEIVSYLEQHPLTNDPYLTEKKIIEAVADFFADKDKAPMGVDMGVMLKLADLNEKLQLPQHLTHYSPFPAKAVSVSLIHLDLFDDTLSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJT4</accession>
    <name>A0AAV6TJT4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003332">
        <property type="protein sequence ID" value="KAG8171958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJT4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="114" mass="13261" checksum="F29501EF2B67B3B4" modified="2024-11-27" version="1" fragment="single">MAGSWFYLIICCWGFRKGYDTREYVDDLGHRMKAISKLKIAEGRAEDQEEFGLHAENEYTSTRFPLATMKRFVTDSALRDASTEADKIPQAFDVELSMRRDVFRNLTVLKKKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKG0</accession>
    <name>A0AAV6TKG0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_019371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002704">
        <property type="protein sequence ID" value="KAG8172437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKG0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8172437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="454" mass="51281" checksum="6F70BF9062B41FE4" modified="2024-11-27" version="1" fragment="single">NEVLSTVAGGKVFSKLDLSQAYLQLPVDDATSRLLTLNTHKGLFRVKRLPFGVSIAVAIFQKKMEEVFAGVDGVLPYLDDIYITGTDMTSHNLKLEEVLQRLDQAGLRLKREKCCFALPEIVLLGFRVNARGIQPTVDKVKAIREAPSPTNVVELQAFLGLLNFYGSFLKRRSDILEPLHKLLQKDVPWEWTAEHEEAYKASKGLLTTDDLLVHYDEKLPLILTSDASSYGLGSVLSHLLPNGKEAPVAYYSRTMTKTERNYSQTDKEALAILAGVKKFHSYLLGRRFRIVTDHRPLLGIFNSTKPIPQMISPRVLRWSLSLQAYDYELEYRKGKDIANADALSRLPVSTPEFDVPQPADILLLESDTQFQVDSKLLAVSTKRDPVLSRTALWVSNGWPDHSPDERFQPYFKRRHELSIHQDCLLWGSRVIVPEKLQDEVLSLLHAGHPGIVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKG2</accession>
    <name>A0AAV6TKG2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002990">
        <property type="protein sequence ID" value="KAG8172191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKG2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="95" mass="11591" checksum="4EA98D2FD1DDA00C" modified="2024-11-27" version="1" fragment="single">MRWREPASGERKSERSRKRRRRERKGERRRKGGERTTRRRANEEKKREEQENETWRKEKGEERKKERGEEREGRKGEKKGGKGERGKKREGGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TM90</accession>
    <name>A0AAV6TM90_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_024825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002356">
        <property type="protein sequence ID" value="KAG8172806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TM90"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="4">
        <location>
            <begin position="3"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8172806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="14681" checksum="94206E8349A6D8E0" modified="2024-11-27" version="1" fragment="single">QTLVSYLPKLYIEKLLRYVVDQLDDTPHLEFYVIWIQYILTSHGIDIKNRSKSNISTLRTMQKSLSHRLEQLDKICGNFKYMLEYTLALNNIKKRKHESTEEETELLLVPQATEEDSSISSEDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPY8</accession>
    <name>A0AAV6TPY8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xrn1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001470">
        <property type="protein sequence ID" value="KAG8173828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPY8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="1">
        <location>
            <begin position="122"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="405" mass="47516" checksum="1175E6ECEE85729E" modified="2024-11-27" version="1">MGITNFCKFINPLHESEPPDRPEYFDSILYDVQPLIHIGISSSLQKHEPQVLNEVCQLAWKRLQMSLLEILPLTTATSVTLILSFDGEGVPMKWPTQRERRLNNNPLDLKTKYRMALFGVNTITLQIQNYFRQKMKSFLFPHVQQLHIYISGCNAPGEGEHKIFQIAEALNTCHHPLVVSVDQDVFILTLMRLSRYETIQIYRYGRYYPVTRLYREWLPYSMKHLEYISFLFGNDFIPTFIGITPINVPDIHQSLQHMDVPDHPTHILAQFINNMSHCIRFQRVTHLDTLLLESFWITYFWIRDYYTQTTFPQKYLENPIYDSFDRNQLLTALSDAEISLVCFENARRAYDQVTREPTTRKQAEYAVFVHDDILNQLSLYWVPPTNAACTVLHLTKKSSRATSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQZ9</accession>
    <name>A0AAV6TQZ9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_022075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001319">
        <property type="protein sequence ID" value="KAG8174108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQZ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8174108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="443" mass="51231" checksum="F5261D372B8C110F" modified="2024-11-27" version="1">MALLRVCQRSNAFSANVKFLARFSSSQSPQSEGDDILPYWHAATGGKVKDFKRMPGPKYLPLIGREWRYNKMIGIYDHDYVNRTFAKMFRQYGPVVKEYIGRDRAVVHLFHPDDMRTVYRNDGLCPTRTFNRVMARYRKERPDLYDSPGLGSSNGLEWRSFREEFVKQCGVYLLKGQKHNLEEVADDLVTRVQSKLDKNREVDVMPLLYRWTLESVGTVTLNRRLGCLDPVYIPEADRLIEAAHITNEVVYRTELMESGHDEQYQKFIPAEDYFAGVIRKYIDEAIEELPTSPENEFLSTILKPETKLNNLYTFVLDLFRAGIHSTAVTAAFALYHLALNRNVQEKLRLEILEELPTEESRYADSQLAKSNYLLFVIQETLRLNPPTIGNGRVLKAPLALGGYNVPASTMVLLHHQVASLQEENFRDAQKFIPERWSKEHRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRW1</accession>
    <name>A0AAV6TRW1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_028719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001243">
        <property type="protein sequence ID" value="KAG8174354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRW1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="105"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8174354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="268" mass="30708" checksum="05885E35D6342FC3" modified="2024-11-27" version="1">MGWRATYREDGTNIKLHGEFFTESKMKTDQSTYVDRLKPDFLLFESQPEPEAPISAEQEPAMPTPVTTRYSRKNVAEVRKCGRRVKLSVEKMPILESNLGRKISCGGALINRQWVVTAAHCVARTSGLRVRMGEHDIKQTTEKYTHEEMAVRRKVVNPGYNPSNYQHDIALLQLQRPVRFRRHVIPVCLPFNSEDFSGQKATVTGWGRTRYDQINQEATFTASGIQQKLEKTSFNLNCRNLILETSSRSSAFLKLESTRFDFSKETLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TS70</accession>
    <name>A0AAV6TS70_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001118">
        <property type="protein sequence ID" value="KAG8174882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TS70"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="417" mass="47502" checksum="85F1ABA5F4D95C2C" modified="2024-11-27" version="1">MSSRSDCIFPRPVDNVAALDSSKDYWIAHLLQVMAYVSHITGEGDRIYHKPLDKNTFIKGKGLEHLKFCLHAVLGEVPFDSRQLDRTWDSIGRRLRRDPSRSLSNSNVCLLFKLHNMFLVKKGFTFGNWLVAEDEQHVIQTSNAAMMCFVLPENSLIPAQERMRRHLPENYQLFYDRYVLPPHGTCLVPKNTRYVLVAVQKTIFALDVISSEYLFQGATPFDACKRYCTQQAEYNVPPPTPCRSPEPPPSTESMMMPPPPCPPKKRKSPWGSYEIPKKNCQPTPEPTPTPVVPEPTLPTTILMQPEIVPLPEKASHQDLQFVPEMDFNSLEMVEEEASEKSVADYVNNFFSNISFGDDPFQKSSFPDLDLSFLEQPSNLILNPAPSKTIFGNPKDFPPVQFFYEEPEQEAPVNYSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUA4</accession>
    <name>A0AAV6TUA4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_004753</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001049">
        <property type="protein sequence ID" value="KAG8175176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUA4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8175176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="493" mass="56128" checksum="3AA2D086DDFD4CFE" modified="2024-11-27" version="1">MEHSNKSSREHSKYVMSCEVIGGKSSVHALSQLSQAKSSCARVFWLMVFVVTASGCAYQVYGFLNLYLQYPVLIDLKYQRVMALDFPAVTVCNLNRITLNHIECVNKSLTWNQCHSYVRRTFCRYGPCGFGGGGGGRPTLLMTEAKSLTSASELLRKYNKIAKNLLNRYTKLDDMSRRCYGHRLDDFILKCSFNSLTCDYSDFEYFISKQYGNCFTFNRRTENDLDAKPRIVKRAGPQSGLELVLDAELISYSNITPSFGVRVVIHSPQEDPHPSEEGVDIPFGVESHLSLAKTSFHRLSSPYRDACKNYPPKGELNCVNECMQRVSMELCGCVDPFLMATRPKKVLCNLLNETQTSCMGRVLDVLSSNVEERLQTCDCPLPCFSTVYDVQLQNTVMNWSLEMRSVMSDRSFGKSYEPEECRGKKKLLSPTKLKVFFKTLDHKIYIQKPMFSDSEFYSQLGGNLSLWLGLSFVAMYEFVEKVFLFMKSLTFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TV42</accession>
    <name>A0AAV6TV42_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_009147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000994">
        <property type="protein sequence ID" value="KAG8175513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TV42"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8175513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13876" checksum="8CE5FBE7369BF227" modified="2024-11-27" version="1">MPCNQFGKQEPGGSPDEIYNGIKHVRPGNGFEPNFQLFEKIEVNGEKEHPLYSFIKAYCPSTRGEFSDQTKLFYTPMRVRDIRWNFEKILVDSTGMPVTRYDPSTKPDDIARDIDKLIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TW08</accession>
    <name>A0AAV6TW08_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000948">
        <property type="protein sequence ID" value="KAG8175841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TW08"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="98" mass="10861" checksum="4D68FD1A50F40877" modified="2024-11-27" version="1">MWKQTTVLETLCRILQTRENATPSFHASGFLNSGSSPCSIRCRQGNIHDAGSDLLCRCRLHSTMVPTTKRRLCQCIKCGETMKLHAFNTGCSLATSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWU8</accession>
    <name>A0AAV6TWU8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000916">
        <property type="protein sequence ID" value="KAG8176133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWU8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="43184" checksum="FD6553BFA53598B9" modified="2024-11-27" version="1">MDGSSQTEQMESRVMSSGAPETIINSHTRASTSVAKPNSNKGQKKSKGKNHQAETMGPKPSSRSVNQDAGINAQEANALPPKVTSLDQDRSPTPQTLAVSESQGESLGGNQTTTSQADASQQPQVEIPYQSKRSDNAQTHDSERSFAEVAGWGPSCPRGPIQVKSTAPSSNSGSSGRDQVKPGNDVKRTRPYIREVLVVGPLGNTSSSKLPFRYFMWNLLDTNGLGKPAHARSTLAGGLVLFLVYLQSLDALEEALGRDDFRERISVRRSCGNSRKPQIKICDMEDIDFEVERNKILREIEVERNLPNVTLRFVFKYSRDSKERRSDWVLEVDPRYWVNVRTLKFFRFRWGRHAVFEFLDLNQCNRCFAFGHGSKRCSKKPLCKRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TX43</accession>
    <name>A0AAV6TX43_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000920">
        <property type="protein sequence ID" value="KAG8176042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TX43"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052090">
        <property type="entry name" value="Cytolytic_pore-forming_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31594">
        <property type="entry name" value="AIG1-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31594:SF14">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="555" mass="61017" checksum="C7A6BF5569C20CA2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYG2</accession>
    <name>A0AAV6TYG2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_015734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000822">
        <property type="protein sequence ID" value="KAG8177082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYG2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="402"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="638"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8177082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="682" mass="76176" checksum="51A48C74A2F5150E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYL9</accession>
    <name>A0AAV6TYL9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_010233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000836">
        <property type="protein sequence ID" value="KAG8176963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYL9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="2">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="14368" checksum="484EEEA5282CA3A1" modified="2024-11-27" version="1">MADEGIYVRREQKKLRQLRYSKEASFEKYIREMVQIITPRMRQEGDANSSISAEALSIADSIILDLFQDVVKEARKLVVSAKRRTLMACDIQCAVLMCLRGEVARHAVSEAQKAVFSYVEKARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZC6</accession>
    <name>A0AAV6TZC6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000778">
        <property type="protein sequence ID" value="KAG8177442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZC6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="14505" checksum="64B1E93C2F091B37" modified="2024-11-27" version="1">MSEKRFSTIMRFLHFTNNNTLDLSTHPQPGIRKIYEVYEALNQKFKSAYVPEKDISVDDSLKLFKGRLGFKQYLPKKARFGIKFYQLCESASGYIWNSIIYTGKDVPLWSEAAAYKTTTNIVMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0D1</accession>
    <name>A0AAV6U0D1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000778">
        <property type="protein sequence ID" value="KAG8177479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0D1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11885" checksum="3DE4C90B9C9B86EF" modified="2024-11-27" version="1">MPPKSYKVIDTWFKKKDKNGHPYSEWCKKLNDEEIQCIVCNKKIACISKGWQAVTQHENSSVHKEEAAVKLSKTQLLVSPRNIGVSCGIQSAVSLQEPKKSTVLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1S1</accession>
    <name>A0AAV6U1S1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000775">
        <property type="protein sequence ID" value="KAG8177521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1S1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="120" mass="13856" checksum="8AC0E075ECE48F52" modified="2024-11-27" version="1">MDSPLSYRSPRPLYVWQDTCRKLHVYCRQRLDHQSACVCHQELESVLQSHVPFVWLRITESGTHEASCPRITSLCSCRYNGFPNYVQVQHAIHRIDCLVKTCDGGAARFMGDPARRIHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2Y2</accession>
    <name>A0AAV6U2Y2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_024605</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>glycine + S-adenosyl-L-methionine = sarcosine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57433"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.20"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19938"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000738">
        <property type="protein sequence ID" value="KAG8177896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2Y2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017174">
        <property type="term" value="F:glycine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006111">
        <property type="term" value="P:regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046498">
        <property type="term" value="P:S-adenosylhomocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046500">
        <property type="term" value="P:S-adenosylmethionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901052">
        <property type="term" value="P:sarcosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000113">
        <property type="entry name" value="Glycine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.46.10">
        <property type="entry name" value="Glycine N-methyltransferase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014369">
        <property type="entry name" value="Gly/Sar_N_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16458">
        <property type="entry name" value="GLYCINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16458:SF2">
        <property type="entry name" value="GLYCINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000385">
        <property type="entry name" value="Gly_N-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51600">
        <property type="entry name" value="SAM_GNMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="7 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="14">
        <location>
            <begin position="43"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000385-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8177896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="263" mass="30218" checksum="68D9968D7F37CC1D" modified="2024-11-27" version="1">MDQNADDVVADAWDDYIGDVDSRLSHYADFLVEFLRKQNCRHVLDAACATGIDSIMLLEKGFKVTSVDASASMVKLALKKRLDRRKEKAFEIIKEANWLTLPHNLAKPDEGFDAIICIGNSITHLKDLSDVKLAIQNFHHMLRPGGWLVIDHRNFESIHGKRHRPKSCMYYNGTVFNDSTIEQTSKYIIRNVCFESSRDKKSDVSSEKKKCRFMTYTIQLGDFNSVLKDVFGQSSKHEIYGDYKPLESVENLAFFIHFIQKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3P7</accession>
    <name>A0AAV6U3P7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000685">
        <property type="protein sequence ID" value="KAG8178562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3P7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8690" checksum="A49DE0F7D188192A" modified="2024-11-27" version="1">MDLRVCGHPWTPVSSEWFNGCKYQQDFLPITVTYSLERVPSHTVDCVCVSILSFVYVRYFDTSPSHAKFELAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U431</accession>
    <name>A0AAV6U431_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_026286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000703">
        <property type="protein sequence ID" value="KAG8178316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U431"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF569">
        <property type="entry name" value="IP01065P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8178316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="8236" checksum="7E3E5D4B32CD65A2" modified="2024-11-27" version="1">MAFVPSLSSHVSMDDYLLTRRRQRRNRTTFNPQQLTELEVLFEKTHYPDVFLREEVAKKINLSEARVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U632</accession>
    <name>A0AAV6U632_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000649">
        <property type="protein sequence ID" value="KAG8179090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U632"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8132" checksum="2A7A74AF1C3A91C5" modified="2024-11-27" version="1">MNRISKSVLKMVRADTPFGETYNFLTSGSKDPGAWGCGACATQAAEERGPQTKCLYSKLRIDMLLKVNVDGYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U639</accession>
    <name>A0AAV6U639_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000639">
        <property type="protein sequence ID" value="KAG8179308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U639"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043428659" evidence="1">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="98" mass="9905" checksum="5517D12B2382268E" modified="2024-11-27" version="1">MKAVIFVVVLSVLLATANSEATSVASLLLGKHRFGGGSYGHGGYGHGGYGHGNYGHGSYGHGSYGHGNYGHGSYGHGGYGHGGYGHGGYGRGGHHGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7U8</accession>
    <name>A0AAV6U7U8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium-dependent multivitamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_017803</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000609">
        <property type="protein sequence ID" value="KAG8179664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7U8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8179664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="64224" checksum="8435F3CA0ABE3643" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U903</accession>
    <name>A0AAV6U903_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_013541</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000570">
        <property type="protein sequence ID" value="KAG8180288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U903"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000233">
        <property type="entry name" value="CLUMA_CG012980, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="240"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8180288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="415" mass="46450" checksum="9A31F45419DAC2D7" modified="2024-11-27" version="1">MYCNLVNVNWELSNTVCDFYIAVDVTCSTASIFNLVAISIDRYIAVTKPISYSKHRSNKRVFLTIAAVWLVSAAIGSPIVLGLNTSPERTPNLCIFYNSDFIIYSSLSSFYIPCLVMVFLYYKIFRAIHERAVQYKRRHKALANRVPSEGAKTDHKPTHAQLHVVVETTTNVPTPSQQPDDEEDDNTTTPKVVEDNNDTTAVPESVVLKFKTRHHSDSIGNNGDSGYDAQSQQDVRLISVKMTDSPVSVKMTDSSGGRSSEGSPFPVKKNGSLVKTGSDAKEDGEGKTLVRRKRCRFNLGKKHKSSSKKREKASAKRERKATKTLAIVLGMFLICWVPFFTCNILDAICIKLDSDDWRPGVNAFLLTTWLGYINSCVNPVIYTIFNVEFRKAFKKILEGMWMQCSGKGKARSVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9H9</accession>
    <name>A0AAV6U9H9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_025360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000558">
        <property type="protein sequence ID" value="KAG8180655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9H9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.75.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032978">
        <property type="entry name" value="ZMYND19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46831">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46831:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13392">
        <property type="entry name" value="HNH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8180655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="229" mass="26510" checksum="30F42312398CBC53" modified="2024-11-27" version="1">MKFEKKSDDSIVPGFMFGLVILGPAAGKLKYTLLDKQDITLLQNYILEAYVDVDRNGEGACVFALAYDIKRGKDAGRYIQDILWEKHYGGIAPGFKVAHRNGITVDNRLENLTLQPKENSHFRASTLKDPEHSLYWSAVVEMPHEAEPLYMKLFTAHEEISLLKEERYFECHYPPCTRIEQRPQEFHICSLCHITRYCSATCQSLDWSWHEPICLQRPRPLNIQGHLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9Z7</accession>
    <name>A0AAV6U9Z7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000558">
        <property type="protein sequence ID" value="KAG8180658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9Z7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7841" checksum="267307E56EF09B3B" modified="2024-11-27" version="1">MASAQHSSSMQTQADQQGVVLPSLKQDNTIQDTIETIQPPDSELAYFYFIFANTPSWFVNHSTMPAYSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UA48</accession>
    <name>A0AAV6UA48_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_008845</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000519">
        <property type="protein sequence ID" value="KAG8181377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0010">Activator</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="12">
        <location>
            <begin position="12"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="13">
        <location>
            <begin position="1398"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="11">
        <location>
            <begin position="1698"/>
            <end position="2114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="384"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="477"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="789"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1500"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1948"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="589"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="806"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="822"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1528"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1983"/>
            <end position="1992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8181377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2125" mass="234695" checksum="31483A4B3F400CA8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAF2</accession>
    <name>A0AAV6UAF2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000534">
        <property type="protein sequence ID" value="KAG8181114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAF2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF435">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="217" mass="24572" checksum="B21D978B4836FA16" modified="2024-11-27" version="1">MRLVSVEPLETVTECTVVNSVETELGDNFEAWGRIKLTTEHPIRQHPYRVPQQLKPELNRQVNELLESGIVQESESPNLAPVLLVRKKDGTYRLCTDLRRLNEHTVPLPYPIPNITQLVDNLGGSGLFFTLDLCSGFFQMKLHPDDMWKTAFSTENGLYEWTRVPMGMRNAPNSFQRLMEIVLSGLSPLGIAPYIDDIIVASSESVDEHFFQIGIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAG9</accession>
    <name>A0AAV6UAG9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)H oxidase (H2O2-forming)</fullName>
            <ecNumber evidence="3">1.6.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">JTE90_005796</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NADH + O2 + H(+) = H2O2 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:11264"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.3.1" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000554">
        <property type="protein sequence ID" value="KAG8180699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042335">
        <property type="term" value="P:cuticle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042303">
        <property type="term" value="P:molting cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009886">
        <property type="term" value="P:post-embryonic animal morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000020">
        <property type="entry name" value="Dual oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000059">
        <property type="entry name" value="dual oxidase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF208">
        <property type="entry name" value="DUAL OXIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0349">Heme</keyword>
    <keyword evidence="16" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="999"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1049"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1089"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1139"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1179"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="799"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="835"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="1224"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAG8180699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1504" mass="173090" checksum="3ED9EFB23E032ACE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UB06</accession>
    <name>A0AAV6UB06_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000517">
        <property type="protein sequence ID" value="KAG8181409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UB06"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="49473" checksum="8FC3155E3F24DAF3" modified="2024-11-27" version="1">MDKNDSKPGRKGVSASKENEIPEFEEDEIKLNLELEEMEPTALEEKSVHEMPDSETNNSKNISGANNKEQNTRPKQKENTQEGTSKSGEDKGTKSQTKTNASSELENQQKPNTSVAIEEEEIETEDTELEDKLKKGTLAFEENNGTKSQIKTNARVYPESEKQQKPNSSVAIQEEEIEIEDTELENKMKKGNLELEDEQCKDTAEDEETAVSLLVGESVSINMQGKSPSVRVLTADGIGVKPKKKESLFSRNLITRLRNSWAKSTNVYDFLFRVVLIVFSTLGWILCSGGLPFVSIAMFIIGSVYINDCKVQPNIPLYLIVGGVFGTIQHFVSFWNKCVPESRQGRLSNYQIYYSALDGAITLFLLIWFIIGCAWVYGVRNVEFQDEYKDEYCHKTVYYFAFWLLNINFILIALVAVLSIGLLLFVIIYPKEDVVAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBY1</accession>
    <name>A0AAV6UBY1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">L27 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_007760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000520">
        <property type="protein sequence ID" value="KAG8181353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBY1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.470:FF:000001">
        <property type="entry name" value="Disks large 1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.470">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015143">
        <property type="entry name" value="L27_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09058">
        <property type="entry name" value="L27_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L27" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="160" mass="18752" checksum="1D10DB3F5CD5383F" modified="2024-11-27" version="1">MPVRKQEAHRALELLEEYHCRLSQPQDKQLRSAIERVIRIFKSTLFQALLDIQEFYELTLLDDTKSIQQKTAETLQIASKWENSSSLGQQHNNQPNKYSPYQDDEDNRDVSDSFPRNIVERVVQDHFISSTESPAPIRKVGLQFSFYSLLFGDISSRHFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCA8</accession>
    <name>A0AAV6UCA8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000501">
        <property type="protein sequence ID" value="KAG8181675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCA8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="202" mass="22958" checksum="F1493E357683BD88" modified="2024-11-27" version="1">MKQSKSTNIKYWSKLFLVWILVALIIALFAGLCVEFWFPATERLYIDGKNTAELVVHGGSKNKGQLHYTAIEKQVELTTIAKEETNPPWHLDFLINPTRLCETWDSPETESYQRNPEVMVDSGSFGPRTLHAKEHNQEDLGICGSALFFRPKALRPHGPVRLGFVLGITSNATQQSLIRHESEAFGDIIQADFVDTFRQPYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCG5</accession>
    <name>A0AAV6UCG5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_028284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000498">
        <property type="protein sequence ID" value="KAG8181746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCG5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12680">
        <property type="entry name" value="RRM_THOC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="98"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8181746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="217" mass="23867" checksum="1571A33EEEC39152" modified="2024-11-27" version="1">MSEQKMEVDLGLEDIIKKHRGKFSNFRTRGGRGNARGRRGRGNIRGFNRGARAGQANDRTKFAFTSPRGAFKARARPAFLTTNRIRRGFNNTAALGPAKLVISNLDYGVSDSDVKELFGDFGNIRKAVVHYDQSGRSLGTADVLFENRGDAMRALKKYNGVPLDGRPMKIHITVQLGQSSNFNENTFAGRGGSGNRFNGRGRGRGMRGRGRGGFNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UD99</accession>
    <name>A0AAV6UD99_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_013962</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000483">
        <property type="protein sequence ID" value="KAG8182031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051129">
        <property type="term" value="P:negative regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05052">
        <property type="entry name" value="PTKc_Abl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09935">
        <property type="entry name" value="SH2_ABL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11850">
        <property type="entry name" value="SH3_Abl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000052">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000010">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000037">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000004">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035837">
        <property type="entry name" value="ABL_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015015">
        <property type="entry name" value="F-actin-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08919">
        <property type="entry name" value="F_actin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="207"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="274"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="389"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="741"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="784"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1286"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1369"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8182031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1497" mass="168121" checksum="B2703ACB9EA99CA9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UG63</accession>
    <name>A0AAV6UG63_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_023393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000449">
        <property type="protein sequence ID" value="KAG8182754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UG63"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000423">
        <property type="entry name" value="Putative inorganic phosphate cotransporter-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="28"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8182754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="521" mass="56985" checksum="AE9ECE1A9F1CF573" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGA4</accession>
    <name>A0AAV6UGA4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000458">
        <property type="protein sequence ID" value="KAG8182600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGA4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="207" mass="23468" checksum="D708A853C76FD60A" modified="2024-11-27" version="1">MIEKNDALLNVAFFAFAPPKNEFGHQIPHYPQVSSSSSILILKYTHSQVSSSSSIIILKYHYPQVSQSSSILILKYLVPHPQVSLSSSSLLLNYPHPQVSSSSIILILKYHHPQISLSSNLFSLYIMMRKRPPYFFDSLATAPDVKVCSETSLIEFVTLKLKVGKDGITKQYEWREKKHGVNGIGKSREIRGRAFCNRKLLRKLFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGW6</accession>
    <name>A0AAV6UGW6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000442">
        <property type="protein sequence ID" value="KAG8182891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGW6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8182891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="292" mass="32128" checksum="7479815494AA8FED" modified="2024-11-27" version="1">MLGCHDNNKVVKVYPLIGNDRFSLTAHLVALCPTLYAFILFLWKCVLLLSPPWEDTIITFIPRIPSMKRLVDYNELPSLVLPTIVLSQYDEADPMVLPEERGVDRERIRSLSGGAKAASPSSSTSSISSRFRRQSGDDNKKMSAVLDAFRPRSKSDSKGKRPTFMSSLRSSMGGGSLSRSTVVSPTSPLATHSTPPYVEPHRPRSGSDSRGAVSKMFDMLRNRSQSVTFDLKNKTKLGTNSSSSLSSRALKTVGGISYNARGEESNLADQLKPHWLKLEPYIPTVHSRDGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHC8</accession>
    <name>A0AAV6UHC8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000406">
        <property type="protein sequence ID" value="KAG8183772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHC8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12026" checksum="3FD926123DD5B2B8" modified="2024-11-27" version="1">MLASKSRVAPIRVISIPRLELCACVLLAQLECKLRSALRLDVSKVVLHTDSTVALSWLATPANRLKTFIANRASKVQRLTEDCQWKHVPSNLNPADLVSRGLGPQEITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJ03</accession>
    <name>A0AAV6UJ03_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maltase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_008909</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000386">
        <property type="protein sequence ID" value="KAG8184127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJ03"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="12">
        <location>
            <begin position="57"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8184127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="877" mass="100086" checksum="08FE2E4569E6A29A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULJ6</accession>
    <name>A0AAV6ULJ6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000387">
        <property type="protein sequence ID" value="KAG8184096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULJ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12037" checksum="E8986E6519628517" modified="2024-11-27" version="1">MSMLICSSYDIDVVCLRNDINIIGGSERASPSSLSKRGEWEGDSGHLSDYTPRGSQTLKRPRSQRHHTVGFETGSMTTLPRGSMDLEADAHLVLWMIGECDTSAFDGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UM36</accession>
    <name>A0AAV6UM36_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000343">
        <property type="protein sequence ID" value="KAG8185207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UM36"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF40">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="18273" checksum="1AA6A8CD28295DF0" modified="2024-11-27" version="1">MMLWESILEENEKKKEVTSWKMISIRVAANFVVTMLLVSSAYAVVLVVARSQEPEAQEDGSWYRQNEMTLVVTFIQNLYPTLFDIVGIFEKYHPRVQLRWQLARILLLYLLNLYTLIFSQFDKVYKTTNELQVIAQNITETIDGPGYNMSRLNEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMF0</accession>
    <name>A0AAV6UMF0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_017754</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000354">
        <property type="protein sequence ID" value="KAG8184899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMF0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000011">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="255"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8184899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="397" mass="46396" checksum="ADB43AE59207AC94" modified="2024-11-27" version="1">MSDAEDDFMCDDEEDYDLEYSEDSNSEPDVDLENQYYNSKSLKEDDPKAALNSFQKVLDLEGGEKGEWGFKALKQMIKINFKMSKYGEMMNRYKQLLTYIKSAVTRNYSEKSINSILDYISTSKQMELLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYYDRAEYNKLSKILKQLHQSCQTDDGSDDLKKGTQLLEIYALEIQMYTAQKNNKKLKKLYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEYEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDNEILAMTNLVSAYQNNDINEFENILKTNRKNIMDDPFIREHIEDLLRNIRTQVLIKLITPYTRIHIPFISKELNIDVNEVENLLVSCILDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UN13</accession>
    <name>A0AAV6UN13_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase A2-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_012860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000333">
        <property type="protein sequence ID" value="KAG8185522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UN13"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase A2-like central" evidence="2">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8185522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="13964" checksum="BBB732F8DB47DDF6" modified="2024-11-27" version="1">MHDLCYEKAGDSVCYDEKPHVAPYRWKYSNGKIYCNSSSVTTTPAKGKAGHACGLVTCRCDAKFTGCIDVYKDTYNPQLRKVRPPLYNAINRFLSQINKKARIDRIEAPFISIKLRRSSEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UN21</accession>
    <name>A0AAV6UN21_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000344">
        <property type="protein sequence ID" value="KAG8185163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UN21"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8250" checksum="2157450B7292D32E" modified="2024-11-27" version="1">MSGYQINPIERFFAQIGFKIIAFIIILLIASLIGMCIKACRKSCCNKNEKLPEVVSEVTVLPPDDAYPKQVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQL8</accession>
    <name>A0AAV6UQL8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Osteoclast-stimulating factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_017569</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000332">
        <property type="protein sequence ID" value="KAG8185566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQL8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11772">
        <property type="entry name" value="SH3_OSTF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24155">
        <property type="entry name" value="OSTEOCLAST-STIMULATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24155:SF10">
        <property type="entry name" value="OSTEOCLAST-STIMULATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 17" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="12" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 18" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="14" id="KW-1053">Target membrane</keyword>
    <keyword evidence="9" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="SH3" evidence="19">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8185566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="217" mass="23749" checksum="77108923149B353E" modified="2024-11-27" version="1">MSGIIRPAPPKPVPKPGHVKVVRALYRYVAQQADELSFEEGDNLYILDIKSNANWWKASCQGKVGLIPSNYVEESTEEVLHPLHEAAKRGNLTFLKECICNKVSVNGLDKAGCTALHWAAHAGNEECVKELLKVPNVEINVQNKLGDTPLHSCAWKGYSEVVKMLLDKGADATIKNNENKNAFEITNDSTCAALLKPHINNAPIVAADDYGDSDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQQ8</accession>
    <name>A0AAV6UQQ8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000318">
        <property type="protein sequence ID" value="KAG8185966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQQ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8492" checksum="7C7A9D789ED5E3FC" modified="2024-11-27" version="1">MRRPSVVVAVQPVNVAEPSAVRSTVRRPKRDLPLPGDPHLGLEETVLFVLFVVVLVTETDSRLHGAGLTPASAREQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USE5</accession>
    <name>A0AAV6USE5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Centromere protein S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_014734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TAF9 family. CENP-S/MHF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000294">
        <property type="protein sequence ID" value="KAG8186658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USE5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22919">
        <property type="entry name" value="HFD_CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029003">
        <property type="entry name" value="CENP-S/Mhf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF0">
        <property type="entry name" value="CENTROMERE PROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15630">
        <property type="entry name" value="CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8186658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="13486" checksum="07A8D3A8FE84690E" modified="2024-11-27" version="1">MGDFENNSELKDNLQTSLHYSVGKICAQTAEAFNVKFSKQFIATLSDLAFHQTGIFAEDLELFAKHAKRTTVTVDDVKLLVRRSKSLHDHVSKTAAEIASKSTKPKSKKKEIDGESSKAAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUH6</accession>
    <name>A0AAV6UUH6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000249">
        <property type="protein sequence ID" value="KAG8188107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUH6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="66" mass="7348" checksum="0AD3566D2B2CD45E" modified="2024-11-27" version="1">MAASVAKCGIAARTKATMQIKGKKEKVIYCGDNANEQTLLFNNNTKSPPTFDHRMRAKTAHREPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UV25</accession>
    <name>A0AAV6UV25_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coiled-coil and C2 domain-containing protein 2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_005504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000264">
        <property type="protein sequence ID" value="KAG8187652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904491">
        <property type="term" value="P:protein localization to ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028928">
        <property type="entry name" value="CC2D2AN-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056288">
        <property type="entry name" value="CEP76_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041510">
        <property type="entry name" value="DUF5523"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052434">
        <property type="entry name" value="Tectonic-like_complex_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837">
        <property type="entry name" value="CENTROSOMAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837:SF0">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15625">
        <property type="entry name" value="CC2D2AN-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24652">
        <property type="entry name" value="CEP76_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17661">
        <property type="entry name" value="DUF5523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5523" evidence="4">
        <location>
            <begin position="218"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="CC2D2A N-terminal C2" evidence="3">
        <location>
            <begin position="645"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="CEP76/DRC7 peptidase-like" evidence="6">
        <location>
            <begin position="1320"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="domain" description="Centrosomal protein of 76 kDa C-terminal" evidence="5">
        <location>
            <begin position="1466"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="435"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8187652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1612" mass="184973" checksum="8AD473646B59E972" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVA4</accession>
    <name>A0AAV6UVA4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_009522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000272">
        <property type="protein sequence ID" value="KAG8187451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVA4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="115"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8187451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="453" mass="50838" checksum="CD463AD999A5739C" modified="2024-11-27" version="1">MPSPIDYEQIAQAQQNDPELQSLLSNSNIFHFKKINLPDCKKAIFCDLSTGTARPYIPKQFREHVFATLHNVSHSGARSTSKLVRTRFVWPSIGKDCTNWAKCCIPCQKSKIARHNKTPLGKFVDQTERFSHVHIDIVGPLPPSQNNYYCLTMIDRFTRWPEAVAIPDIRAETVAKQFYATWISRFGCPERLTTDQGRQFESALFRALSQLLGIKKLRTSPYHPQSNGLIEEFHRPMKATLKAYDTSEWAAALPTLLLGFRTAFKEDLRATSSELVYGQTIRLPGVFFDPTPTEATPQQLVEELRSHFGAFARANVEPRKESDVRPPSDADLHPRLCAARRRAQATPSTIRRTVSSPGEEGEDLRLGDKRRAAHHLDRQIEASVRRCRLTTHQSFNSSRPGSGNTAKYPLSGGALAIISTGSEQTARLDRLRADDNPCWLSAANTLSTSAVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVV7</accession>
    <name>A0AAV6UVV7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000254">
        <property type="protein sequence ID" value="KAG8187933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVV7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8729" checksum="AC88794E70A59F50" modified="2024-11-27" version="1">MSQIEADIAASNNCIEKFAEVFRSSRSLHWVQVCSLSLFLSRIFKDWLIMRQVDRRKTAECPSRLTQMVTKCQCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0B0</accession>
    <name>A0AAV6V0B0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000198">
        <property type="protein sequence ID" value="KAG8189989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0B0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8773" checksum="B766C7E454D9A303" modified="2024-11-27" version="1">MRGCARFENLGSQNFKEWRTDWRCLQNRGFLVCIREGNSSSKTEPAKPYGIPEAKGQGHFDVYRGLALPQAVIASEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1F4</accession>
    <name>A0AAV6V1F4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000184">
        <property type="protein sequence ID" value="KAG8190446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1F4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="7974" checksum="D54C86420DFE2FD8" modified="2024-11-27" version="1">MWSSSGGLTGMLWMCSSSGGSPSRWTGVLWMWEDGGALLTVAEGAERERNVTLRHFREPILHEFTTIDEAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3R7</accession>
    <name>A0AAV6V3R7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000181">
        <property type="protein sequence ID" value="KAG8190526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3R7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="37261" checksum="2F9E2BCF736F25B2" modified="2024-11-27" version="1">MKNILRKLLIVVFVLYHGVTGLVILNYCRNFKVEGKDIRLTWVLFLQCLMSIGALLLYRKRKLIQETTYQLDMYLKPFKEIIMEGRVIKFRIITVLGCAVIVLKLVTVSCFLWLNIFSYQVSLLQSPTTLWLGLLTFSLVYLAMMGLALMECFLLYYCLLCWVLKRAFKVYIDLLDNNLDGRRIISYHSRITNAVSCVESGNSVHLFWIFLSFLLIFFSETYIVMHNKTNQLEVIFTVWSAMLFFVTVMSAASVGESADSLKRYVSENDSKFDDNVFYRMNLKMSASDNQLTVCNMFILKKVTLIHVIGTFITYTIMMIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3Y9</accession>
    <name>A0AAV6V3Y9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphodiesterase</fullName>
            <ecNumber evidence="8">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_010844</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Vital for female fertility. Required for learning/memory.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="8"/>
    <dbReference type="EMBL" id="JAFNEN010000169">
        <property type="protein sequence ID" value="KAG8190986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
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    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:anesthesia-resistant memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:conditioned taste aversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDE4_UCR"/>
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        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF18100">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDIESTERASE1"/>
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        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0114">cAMP</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="221"/>
            <end position="549"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="296"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="336"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="337"/>
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        <ligand>
            <name>AMP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
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    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="337"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
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        <ligand>
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        <ligand>
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        <location>
            <position position="505"/>
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        <ligand>
            <name>AMP</name>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00053071"/>
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        <source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8190986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="557" mass="63091" checksum="8C76A0E1AC214BA6" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V593</accession>
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        <recommendedName>
            <fullName evidence="3">Zinc finger CCCH domain-containing protein 14</fullName>
        </recommendedName>
    </protein>
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            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Nab2/ZC3H14"/>
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    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="417"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="417"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8191243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="543" mass="61811" checksum="2E33667F39560C51" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5K1</accession>
    <name>A0AAV6V5K1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5K1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043720040" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15591" checksum="6DE946031F33F0C6" modified="2024-11-27" version="1">MLSLSLLLIAALSTHCAGVPTVYDVLQLVYQLCSTAEAVREERLDCVGEHLGREVSPAVSRCLPPVLCARTLEWAAKHPDTPPHRITRVLGLGALGRMGCVLGEVPRPLPVWKAAFAKCFPDFQSVDSLNKDGSTGRSGNSLADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6W0</accession>
    <name>A0AAV6V6W0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000142">
        <property type="protein sequence ID" value="KAG8192232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6W0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043574436" evidence="1">
        <location>
            <begin position="24"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="234" mass="26468" checksum="0591073575FE8F98" modified="2024-11-27" version="1">MKGLYFSCLSVLLLAIFATEVQSQACHLREMDLCVAIGMFHYQSNGIPADEEKVDEWCETMQEVRDCMGNFTTKCMSPLQREMMDLLTGSDEIALQFCQQGSEVRSNYLEHAECLAEGSESDEFKNHMKDLQVVIETMFEVQFKQRFPLMCCGFRRFHIAVESMTTQRCGQEAVDMIRNIMHMITTDLPETICQTFDPASDQCTAVMPPSGTPSKGTDNKSQIGKLMDTVFGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V790</accession>
    <name>A0AAV6V790_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_027758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000144">
        <property type="protein sequence ID" value="KAG8192111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V790"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051606">
        <property type="term" value="P:detection of stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421:SF29">
        <property type="entry name" value="GUSTATORY RECEPTOR 5A FOR TREHALOSE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8192111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="193" mass="22140" checksum="DE2166E83E34BA71" modified="2024-11-27" version="1">MCLNSRMWLRHFRKLYKASDITEQNIGVRSFRKSYENLCEIVSLLDDAFSEMVGIWLFMILVIICVRIISVLNPLTVTTDQMMTVILLTLFRAMGTLLGSCFLGDSISSEGKNALSLLIEMARRDNCYAWNNSAFFEIQLIITKYALSPLQLTVIKFARLDRKFLMSCMGMMTTYIIISIQLYPNAMKGLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8D4</accession>
    <name>A0AAV6V8D4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator complex subunit Med25 PTOV domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_029088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000140">
        <property type="protein sequence ID" value="KAG8192353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8D4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.30">
        <property type="entry name" value="Mediator complex subunit 25, ACID domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021394">
        <property type="entry name" value="Med25_PTOV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038196">
        <property type="entry name" value="Med25_PTOV_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11232">
        <property type="entry name" value="Med25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mediator complex subunit Med25 PTOV" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8192353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="325" mass="37279" checksum="27F906A595442939" modified="2024-11-27" version="1" fragment="single">VGCIQFPATCDIRIMVVLYMPDKQIYMGFIAHDQEGFFNSIKQRYETHRKQQQQRLLANIPPSDGSMGNQPNNPQNPNMMMQPQQPVNNLNPNPNQMNMPGMPGVNPQQQQQPPPQPPQQQVPRQVNPPPPQQQQQPQVPNQQPGLQQHSGNANNPANAARLNQLEAARQQNLVRQQNLMKIQQLQQTLEAAQQKELQFKAAQEQQKQQQAAQQQQMIERQTAIRHLEQQLQHQQQQLAQQQQSIQMQQQQQQQSHNPQLRNLLQQQQVQQQMRRQMLMQHNPQGIRPQIPGNLAQGGLGGQQQQQQQNPQQAWGDLGILDSLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V967</accession>
    <name>A0AAV6V967_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-protein ligase E3C</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">HECT-type ubiquitin transferase E3C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RTA-associated ubiquitin ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_002099</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with 26S proteasomes. Interacts (via the HECT domain) with UBE2D1 and, less efficiently, with UBE2L3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the UBE3C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000141">
        <property type="protein sequence ID" value="KAG8192273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V967"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000011">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000014">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="727"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8192273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1067" mass="122225" checksum="E1EA4A4D2EBD5748" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAQ4</accession>
    <name>A0AAV6VAQ4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_004951</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000129">
        <property type="protein sequence ID" value="KAG8193127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAQ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF33">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043596801" evidence="9">
        <location>
            <begin position="33"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="46"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="143"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="239"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="341"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8193127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="499" mass="54978" checksum="7C5D29E64D39F727" modified="2024-11-27" version="1">MVSQLGDKLASPVNMEGATLLAFVLLIIAVESGTLHTDETTEDGIPRMISSSRPLRIREGESIELPCKAVNINGKVRVWKKLPSRTLFSGSISVSRDARIQLLEGSTLKLEDIIPEYSGEYICQISHQPLLNVTYKIQVLVPPTIIPDPAHGKAIVRKGNPVTLLCDVQGSPKPIVTWTYDQDGESTSTLPSGVRQVHGTQLQVASVDVHHSGIYKCTADNDVGDPVSATFNMTILYAPEVTVTPEWIHGDEMVTVEFTCTSHSMPMSQVHWVRGVDPKQGQHLKSNQYLKITDSVVHPTTTESRLKVQNMRREDLGSYTCVAKNSVGVTFKKVEVSGLAEPVQLRGMESGDSSFQLLWTAKSYSPVMEYQLKIRKHKSGDAWTDVVIPVSDDAAHQSLFFSQSYNVTGLDPGFKYEAVLQAHNDHGWNRPSDTLLFNVGPTPEPDIEEPIILKTVIPFYDADLDVTDPTFLKQDSSSSSSSYSSSLFILSLTFIFCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VB75</accession>
    <name>A0AAV6VB75_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">JTE90_027021</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000126">
        <property type="protein sequence ID" value="KAG8193277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VB75"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000199">
        <property type="entry name" value="Glutamate receptor ionotropic, NMDA 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000155">
        <property type="entry name" value="Glutamate receptor ionotropic, NMDA 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000009">
        <property type="entry name" value="Putative glutamate receptor ionotropic NMDA 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044011975" evidence="20">
        <location>
            <begin position="25"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="21">
        <location>
            <begin position="18"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="22">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="16">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="16">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="329"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG8193277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="573" mass="66170" checksum="A15B2B0A387F8CCF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBB2</accession>
    <name>A0AAV6VBB2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mab-21-like HhH/H2TH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_026998</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mab-21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000126">
        <property type="protein sequence ID" value="KAG8193254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBB2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF42">
        <property type="entry name" value="CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="13">
        <location>
            <begin position="186"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8193254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34864" checksum="E61FC3DAA7506AB9" modified="2024-11-27" version="1">MQILIFIKVKELENLPYVTFQVDKNSLNELKDDKLKSLFDGNYLILKKVHSWFQSNVAKFCSYCEKTSKFKDLGILKVEKSESGPACTLKLCTSSHVTKGNVGTSQFEHISVDLVPVFLIDVDHLTRYTYSNIHDLSEVDGQYCHMVPKPLKKELNFLTPSTASKAWRVSFPVQEKHTFADKEPLKIVMKLMKMLRDHENWKMPSYFCKAAAFWLVNKHPLSSYWSDSDLGDLFLECLDDFHKHLTLNHLGHIIYPNFNLLHTLTPNTIEQIRKRIQNIQGKLQRNPAYAYSLFKSYQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDN1</accession>
    <name>A0AAV6VDN1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Unconventional myosin-VI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_029186</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000097">
        <property type="protein sequence ID" value="KAG8194895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDN1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21759">
        <property type="entry name" value="CBD_MYO6-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MYSc_Myo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21958">
        <property type="entry name" value="MyUb_Myo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000006">
        <property type="entry name" value="Putative unconventional myosin-VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1590:FF:000002">
        <property type="entry name" value="unconventional myosin-VI isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000018">
        <property type="entry name" value="unconventional myosin-VI isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049016">
        <property type="entry name" value="MYO6_lever"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032412">
        <property type="entry name" value="Myosin-VI_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036114">
        <property type="entry name" value="MYSc_Myo6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF745">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21521">
        <property type="entry name" value="MYO6_lever"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16521">
        <property type="entry name" value="Myosin-VI_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 11" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="14">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="13">
        <location>
            <begin position="55"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="11">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="839"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="149"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8194895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1220" mass="140808" checksum="76ED799F9965F236" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDP8</accession>
    <name>A0AAV6VDP8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_005067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000115">
        <property type="protein sequence ID" value="KAG8193773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDP8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043753499" evidence="2">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="8956" checksum="22BA9161259969F1" modified="2024-11-27" version="1">MNKLVLITLAVLLVSLSVSADHLGHGYGLHGHGFSGHVDEHGYKVDIEHHGHGHHGHHGHGGSGHSSRYFHMQGHHGHHGGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VH04</accession>
    <name>A0AAV6VH04_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CAAX prenyl protease 2</fullName>
            <ecNumber evidence="11">3.4.26.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Farnesylated proteins-converting enzyme 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_028411</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="11"/>
    <dbReference type="EMBL" id="JAFNEN010000090">
        <property type="protein sequence ID" value="KAG8195260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VH04"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="14">
        <location>
            <begin position="109"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8195260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="271" mass="30978" checksum="197BAEFB7D6A39B4" modified="2024-11-27" version="1">MYVGSLYIWKNTHRRDHPSTIKKRFLSVFFMSFVSAVVAYVVADRSYFGYETSYWSLIGLRYSGLLEASIWPLLLTMVLFLGPMCLHYNDGGYNTMFDLKLWKYCLTNAVWLRNHVIAPFFEEFTFRACMLPILVPCFGNKYSVIFCPFFFGIAHLHLLSEKLANGALLKVAILQSLFHCAYTTVFGAYSTYLFLRTGHLAAPVIVHAFCNHIGFPDFSQLLTLKQPKKSWLMGCFVAGLLAWMVILKPLTDPNMYAILVLDISLIASHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJC0</accession>
    <name>A0AAV6VJC0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_006567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000066">
        <property type="protein sequence ID" value="KAG8196657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJC0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14304">
        <property type="entry name" value="UBA2_KPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041927">
        <property type="entry name" value="UBA2_UBAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052476">
        <property type="entry name" value="UBAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057650">
        <property type="entry name" value="UBL_UBAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46738">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46738:SF1">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23326">
        <property type="entry name" value="UBL_UBAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="181"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="323"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8196657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="449" mass="50167" checksum="71CDD8CA83F4DE9D" modified="2024-11-27" version="1">MYVVETSLGSIEAMKITVINPTGAYWVVDVLPEFTVDKLKLMALSHFFNPMDSIKVSDRYKLILVSQNRPLPDESTIRDEDIRENDELLLLKKRPLPVSVGESQEEKEEKCRGPTEAEITKETATVHPKNLDAVVENPSVPVDFHTELRKILVSLVKVSEKLLRYHPEVVALFKEMAEGDEIKEEESCVDKTSLKQLTDMGFLEAQAIEALKQNCNVSDAMDWLLAQSVDANTSLNPSTAKANSSPIHTRKFSVPKFCVSKLVEKATGEKSSSTEKHSASTSHKHVDTEVPSTSSQSTGPNGEQNRIVEMIRCFRSYKRKVFRPSSAALANLKEMGFAEADILDALRINGNNQDTACDWLLSDKKPNFEDVEEGLDPEGPIYKSIMSNAVVQLGLSNPKTFLALLHMLENPTSACRWLSDPDTAPILSQIFRIYHAEKHSLQLARPFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VK53</accession>
    <name>A0AAV6VK53_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_023818</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000073">
        <property type="protein sequence ID" value="KAG8196262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VK53"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590:SF0">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR627179-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8196262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="11155" checksum="5F8AD079D11CFBD1" modified="2024-11-27" version="1">MSCGIVPWSSVLCELMTPDPCHSKAIDMQRCLKANRYREGACFGAMTVMEKCCTRWKGRSSCCMFYETKRPSTVSRKNPVNDLSTDHFMLFEIFLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VL52</accession>
    <name>A0AAV6VL52_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_009058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000070">
        <property type="protein sequence ID" value="KAG8196428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VL52"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF551">
        <property type="entry name" value="RE08073P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8196428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="255" mass="27723" checksum="D7555BA2C01F47B1" modified="2024-11-27" version="1">MGLSCGAKCAKGFLVTFNLVFWISGCAVFASGVYLLVDKDKSTLFRLFAEPTTQYAPHQWLAWALVGTGALVFLGGFCGCCGAIRENRALLVTYFIFLFLIMSCELAVGILSVIFQNKTIEKLEGLSTLLKDEYGIDGATTEAFDYAQTKFNCCGVYGPGDYEDSTWRSQDLGKGDLVAKTCCVLANSNHLDPRPTNGTLCQSADSATYRHEVGCLEKLEDFVRDTTMLLVAIGCGVAALEIFGMIFAMCLCKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLF8</accession>
    <name>A0AAV6VLF8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_027592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLF8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8196880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="119" mass="13790" checksum="4DD9E2BF340122FC" modified="2024-11-27" version="1">MVAQRIYKCSVCSREFNYKHCLRRHEQVHKEVRQVHTCEICGAHLKRKDTLKEHMMLKHNVMLEVIILKGNHPDITHVTIVANNFLGGTTFCVIEDGTTLFKLSMLVNFVPVHLPERIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM95</accession>
    <name>A0AAV6VM95_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000062">
        <property type="protein sequence ID" value="KAG8196937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM95"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="148" mass="17058" checksum="B36C550410B7C10D" modified="2024-11-27" version="1">MNSRPLTYISENNKDPVPLSPSMFLQDIQEWRTPDLDSVDQKSLNRRPSTCDPIQAVLRALENVDLAAEDRRVSAMKKNNPSYRSQPRSPMFQDHVDPYKTALKKIEELQMKKKAKSTRKVTFNLESSGRKESMLRMSGLKVRPSQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMC1</accession>
    <name>A0AAV6VMC1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMC1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10482" checksum="C2F070C65B264623" modified="2024-11-27" version="1">MQQLDSVLREVNPSAKSYTKMHEIFKNNPATSVKMVFMEDGSLDMRRYNVPTIRTEVAAIFVGDDGEPPANRDIIFYPVDSLQNNFQNQPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNK2</accession>
    <name>A0AAV6VNK2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclin A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_020096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000049">
        <property type="protein sequence ID" value="KAG8197818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNK2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20504">
        <property type="entry name" value="CYCLIN_CCNA_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="171"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="264"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="268"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8197818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="44486" checksum="E3121CE1BA5730E7" modified="2024-11-27" version="1">MAQYVSYSDNSSVIPPNKIINDGQKRPALSVLNHNQRLQPKGGKSSQWLKNDDSTDQSKTSSMGFQIFQDVSMEAKDISMAKTPSLPACVTRLITLNDHRDSHKENDSPYWEFPVDPAAEQKKKDELNWTCPYQSDIYQYLTEQELRFRPRPNYMKKQPDITMNMRSVLVDWLIEVGEEYKLLSETVHLAVSYVDRFLSQMSVLRAKLQLVGTACLFIASKYEEIYPPELKDFVYITDDTYTKKQIIRMETLILQILNFDLSSPTSCIFLQLYGTIASMPERDLFLAQYICEISLLEADPFLAFLPSQIAAAGIILANYTLGNTILWPEELGRTTNIEVSQVWSIVEFLYVKYKGINSYPQQAICEKYRSTKYQRVAEIQCPESLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNK4</accession>
    <name>A0AAV6VNK4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_007557</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNK4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8197311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="56748" checksum="8638642867A00A36" modified="2024-11-27" version="1">MGDILNVWSIILGIFILSVSVFWWQKKRKYHLPNGPWSLPIVGYLPFLGEKPYKDFEKLSKKHGKVFGLYMGPDYTLVLNDYESVKEAFSNNALLDRPDHLFDFNPAPTGFTSANGEEWMEQRRYSMKTLKDIGLSKNPWETNLEVEIEDFLNLLESKAGNPVDISHELLASVSNSMTSIVLGKRLMLDDPRRVTVDKGIEAVIESFGQNSVVTIFPNFMKFICKLGLTRWAEIYRNLDAFKEFFRNAVEERKKVFPNQKEDNYIDGYLEEMSKAKATKSYFNEDNLIGSAETMVMGGSDTSKNSLMWIFLAMAAYPDVQKKIQDEIDRELGRDGKLPWMQRTKLPYTYAATLEVQRWKTTAPLGVFRRANTDTKLGEFDIPKGTNVLGNFWLLHNDPKYWKEPDSFIPERFLDSEGNLLTLKPESYIPFSIGRRNCPGEFVALIEIFRYFTAIMQRFHIRPLENKPPILEGLMKAVYAPIPQKLRFIPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPR9</accession>
    <name>A0AAV6VPR9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPR9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7912" checksum="34C06481D798EBDC" modified="2024-11-27" version="1">MPTHSCHGDSPTLQRALSWVDATKLSANLSGISLQKRNQMLKGMSLRIRHFYDDELEICLRASWIPWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQU2</accession>
    <name>A0AAV6VQU2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000044">
        <property type="protein sequence ID" value="KAG8198099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQU2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="11820" checksum="2367CF7BA9B09506" modified="2024-11-27" version="1">MHVRWDIFLQPEIGKKPLAPRKVLIENPLLMMSQGFGRGTTPLSRRRKCAAGEIGSVLFWNATKKTGIHLLVILHRIWSENNNPLSDGGTMVRSVRDPDFSIELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRD6</accession>
    <name>A0AAV6VRD6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000032">
        <property type="protein sequence ID" value="KAG8199060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRD6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="151" mass="17432" checksum="0FC9E570EBF1F927" modified="2024-11-27" version="1">MGPCDNARPCFAAWFAEWRAHLSRYRSLWVKPDSTQKLYAVPKHRTETQTVSSLRFRYATYGLTPPSKAPRRRELKEESHLTPHMDRFMIVMTSICEHSPPNPSITLFEATDTAGKLQCSDAVPNHIFSLTLYTTYPHQTLYSQKDRKGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSP1</accession>
    <name>A0AAV6VSP1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000031">
        <property type="protein sequence ID" value="KAG8199100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSP1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="144" mass="14983" checksum="758ABA97462FFBA4" modified="2024-11-27" version="1">MSRQGKGPTPANPAVPGAVAQQAQQYLEQNIMAWMQPKPQGQQILSSTLSTFAGGPQMSQKALHEHNLTTRQTTHSANSSNNASPSHAGTSCVGLPPSCSSIPHSLSFSGYSHHSLMQGTSFSSPCPSTFGAAQPSAAASFFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTF3</accession>
    <name>A0AAV6VTF3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000022">
        <property type="protein sequence ID" value="KAG8199987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTF3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="238" mass="27394" checksum="0960A18EBC979374" modified="2024-11-27" version="1">MEEENWRIKSEENRSRYTSPRFSKNRGVVVVNRRIQSTENAEKDTEKNTGRPVNSRRQRKASNHRQSLLQEELLLPSQVMDEEYIYFPSDPEAISNMKSETAGKWLVNGNSDMPRQDKAWVNLLPLCKEGILIGMKASTSIIADVQEFMAGEVILCYTQDADDVKDVKKAGDAIMLAIGDWRSWRNDKILYYKTNAASVGGLYVKEGFKAVTKYRLTPEGSFDVRDHHKRWNPVQMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTJ1</accession>
    <name>A0AAV6VTJ1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTJ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="163" mass="18906" checksum="867D40C5E21DA420" modified="2024-11-27" version="1">MSHVLIGTQSAKPDTLKPQPQSHKKHPPPEEKKPESIRDREERSAIFMNRKHFMGRIVGALRTYLCPHRLSQQTHQVDHLMNGRDPFKTGGRPFYGPSGGENHLVLDAEIITPFCRRIRWPFYGGRSDLFDNSKKRRRKNIVGMSFGCGKKRCREVLKEIFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVF8</accession>
    <name>A0AAV6VVF8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_022266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVF8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8200644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="40913" checksum="E581D09AD8DD33F0" modified="2024-11-27" version="1">MIEHGKLSQRKLCKQFSRSTSLDNCPAEGITVTGASRDNLHKISENGLVFESNGIHDHKKIDNKNAVICTRYKNQGSPKWERNVERQYGAYLKTPNIKTISESLQNDPNNQPEGPYASSKSQDAKNQNTQSITQSLKSMVKLYTNPVYVLINVCMSTYILIFIPILTVIVDYGIDKGIPEIYGKYLINSMAIGDLIGRLGFGWVTDKKLMTVSSFMCLTFILQGISIMLFPFAISLAFFMALLILYGIMAGAILVLFPVLVLTYLDINTQTVGMACMPFMSGIMSFAIPPMIGHFRDDVGSYDGMFYLTGIISIVSGGGWLLEPVVAKWYYGKKDMKTEKEADVHNANLNQNNHMDATDCQNKSVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VW66</accession>
    <name>A0AAV6VW66_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WAPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_006199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000022">
        <property type="protein sequence ID" value="KAG8199953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VW66"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012502">
        <property type="entry name" value="WAPL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51271">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAPL" evidence="4">
        <location>
            <begin position="510"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="952"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8199953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1058" mass="117935" checksum="02523260E2F52900" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWX3</accession>
    <name>A0AAV6VWX3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Espin-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_022323</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Stereocilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWX3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032420">
        <property type="term" value="C:stereocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052420">
        <property type="entry name" value="Espin/Espin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153">
        <property type="entry name" value="ESPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153:SF8">
        <property type="entry name" value="FORKED, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1009">Hearing</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="11" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="13" id="KW-1053">Target membrane</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8200713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16334" checksum="B3C978A9C6DADA7F" modified="2024-11-27" version="1">MKSMKKLAEPFIPPPLCWSHHLPHPFGPYPTMPEVPLIHRALVAAREGDLQGLQLLKKKQELLQGLHDDFGATCVHYAARGGHVKVLEFLVSKCGMRANVRSFVGATPGHDAAAMGKLPALVWLLRNTDCTLWDRDKDGATVMHIAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VX29</accession>
    <name>A0AAV6VX29_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000010">
        <property type="protein sequence ID" value="KAG8200980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VX29"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043417357" evidence="1">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="152" mass="17858" checksum="E03CCA66D2B99B4A" modified="2024-11-27" version="1">MDSVHLLVVLIVISSAKCQGMDFFNGFQGTWDGMGNNDFMKMGGLDSWENFENVFKEMSDHFKEIKPMPNWYDGPNVCTQESYREREHIRINRSFEEYQDHQESENCIGRDFKYVCINRMFVDGKSKERRTTYECCPGFIGSFHNGMKCVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VX65</accession>
    <name>A0AAV6VX65_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000004">
        <property type="protein sequence ID" value="KAG8201597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VX65"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="63" mass="6995" checksum="B0402946E2965956" modified="2024-11-27" version="1" fragment="single">MSRRKQAKPRAFKREDVEPLPDESTEELCSVLGNSQKENDLISAAGIESNSTLDSPLFENSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYH9</accession>
    <name>A0AAV6VYH9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_028781</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000008">
        <property type="protein sequence ID" value="KAG8201113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYH9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000202">
        <property type="entry name" value="Short-chain dehydrogenase/reductase family 16C member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF746">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 16C MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8201113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="305" mass="33526" checksum="F35C6AE4BCF524A6" modified="2024-11-27" version="1">MNDLAKTIGQYLAILYYWIEGMILFFVPLKFKAKDITGELALITGAGSGIGRLMALKFAEKNANVVLWDINIEGNEETARLVREKGAKAYTYSVDVTNNHAVYETAAKVKEDAGIVTILVNNAGIVCGKNILELDDQMVRKVFDVNVLAHFWTIKAFLPDMKEQDHGHIVTIASLAGMSGIPSLTDYCASKFAAVGLMDALLTELHAEGRKNIHTTTICPFYINTGMFSGAGAKLFTNLEPDYVADQVLAAIQCNKAIVLIPRVFYFLFQMKTLMPARSLMSLQDATGGIHSMDKFTGRNGKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYJ2</accession>
    <name>A0AAV6VYJ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000011">
        <property type="protein sequence ID" value="KAG8200897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYJ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="113" mass="12781" checksum="FB76D5BF7A8ED272" modified="2024-11-27" version="1">MDIRFVKGQDNTVADAMSRIAAISLPTPFNYEEMSVSIASSKALSSVTPRSGGWKSCLVSYWVFGPIFDRIWGRLRQNWSMANLYVFLANSFVHLSHLPHTQSTYEGYEVPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W2D2</accession>
    <name>A0AAV6W2D2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W2D2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024857">
        <property type="entry name" value="Cappuccino"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16230:SF3">
        <property type="entry name" value="BIOGENESIS OF LYSOSOMAL ORGANELLES COMPLEX-1, SUBUNIT 4, CAPPUCCINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16230">
        <property type="entry name" value="CAPPUCCINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21784" checksum="58A3FCCB3C9A673D" modified="2024-11-27" version="1">MADELQSPDVTKNVLPEEVLEDKSKLNKLVSELSDDYSKYMKVDVTTEKSILEDEIEEILTRLDEFTSLVDMVRGDNALCLNQTLPEIHKKCSEIEKVFHQVDRLEDMVKAIKQNLDVMEDKVNEAEVHLDTSSVKKLFNSLQKPLFSKKAAEPKKQIKYEPPVIFRTEDFFPNSNTVEEATGTTEITGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W3K8</accession>
    <name>A0AAV6W3K8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ras guanyl-releasing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_027285</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RASGRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W3K8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20808">
        <property type="entry name" value="C1_RASGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000003">
        <property type="entry name" value="Ras guanyl-releasing protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF252">
        <property type="entry name" value="RAS GUANYL-RELEASING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 7" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="11">
        <location>
            <begin position="44"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="9">
        <location>
            <begin position="214"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="479"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="517"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="10">
        <location>
            <begin position="550"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="625"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="668"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="668"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8201804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="772" mass="87317" checksum="B8D3EA78A67DE065" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TD36</accession>
    <name>A0AAV6TD36_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007369">
        <property type="protein sequence ID" value="KAG8155673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TD36"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="150" mass="16285" checksum="F24FF798EB140A19" modified="2024-11-27" version="1">MIGKGSRHEGQKATSLNPLAATSQLPPGNFSTPFAKNFVKSKGSTAQLSQPFFILKKKIKRLLLLPTRGFCPRELALWGICVFPFTEYAPAKQPTFNFVLGADRALPRGGSGPLGVEADPYGSLFPLKGVRERNDESSGFHYPPASTPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TD80</accession>
    <name>A0AAV6TD80_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006561">
        <property type="protein sequence ID" value="KAG8155826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TD80"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8155826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11143" checksum="4A1D4FB706855B05" modified="2024-11-27" version="1">MRWIKREFPTVPIYYLANRSKGNGLGKISGGKKGPMLSLTLAEFVKRHESGSISGRCLPVSEIPLLHRFFTYSVKRKATLRITLLPQARCLLCRARSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDF1</accession>
    <name>A0AAV6TDF1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006950">
        <property type="protein sequence ID" value="KAG8155716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDF1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="130" mass="14633" checksum="C8BF660BD0E0A334" modified="2024-11-27" version="1" fragment="single">MKGSRKSRIDPSPSKGVPKRAVEGTTSETRSRHVYLRMWKIRMVEKGTSPFPFFGAVPKKEKKTALGFHGKKWRGCGSLRNGDNKPKIISAKNTPRGRFPPGPKSRTAAFTGCFNGTRHYQSVLQYFCQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGG0</accession>
    <name>A0AAV6TGG0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004681">
        <property type="protein sequence ID" value="KAG8170922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGG0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="102" mass="11412" checksum="404BF746FBE27A33" modified="2024-11-27" version="1">MLTCARVNGVLKSARRRNEVTGRRRWRIGIPVPSRAGRTGVDRRVSQLVEVAEVSAHVGTRTKDGENYARDHGRGQRKLWWRSVAVLTCNRSSDLGSSGVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THS8</accession>
    <name>A0AAV6THS8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004289">
        <property type="protein sequence ID" value="KAG8171216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THS8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="140" mass="15388" checksum="587C2B293AEF50D2" modified="2024-11-27" version="1">MVPRTHFGQTAPVKGTCAESVSASSLLNVTFPTPLRAGDSALGFSRFTRVTKGIPASRLLEHSKFIQVNLPVQPRQPVKIIKGNRLACSERAVTPHVGATARLELRIQLRLFNRNNFNIRYWASVTAAAGTWLAPPIDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TK20</accession>
    <name>A0AAV6TK20_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002994">
        <property type="protein sequence ID" value="KAG8172189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TK20"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="167" mass="18674" checksum="FE7A9A5F8A7D27B5" modified="2024-11-27" version="1">MPSGHLLATVCWEPQAPRPRGFEDNPKTSHLTYENHGRAHLEAFWQKKGFRPVVGSSNPRDDPTRFTCLPALHAAIGNTCGKERKNSAVTLEEQHCIETHSRQRLRAADGFGGKNWPGCVQQNFATGRKKDVWMLFLRSTGLAGDKDPKTIRGTRLRCEGRTPKPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKV4</accession>
    <name>A0AAV6TKV4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002833">
        <property type="protein sequence ID" value="KAG8172313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKV4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="160" mass="17170" checksum="C91FC40922CA2A35" modified="2024-11-27" version="1" fragment="single">MTNFSYAIAKFQLLSAADTRGVSAFVGYIGMPGIICITLADADFGDLRWELVLALFLGKCFIFVLVAGVTLVINGNIGIAGLLAVFCVHTNDLPVGNPLRILLNLTFREKLPSTIHQPIEAIAATVPGCVLSILGFNMVRKERYLLTSSVITATVLLSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNK6</accession>
    <name>A0AAV6TNK6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001827">
        <property type="protein sequence ID" value="KAG8173377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNK6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="118" mass="13317" checksum="0F71821EFEBFCA43" modified="2024-11-27" version="1">MVLLKKSRSQGPSAFRQKSGPSAFRQKSRNKCLSVKSDQVQKSKDQVPFGRSPGPSAFRKKSRTKCLSAEVQEQVPFGRSAEVQDQVPFGRSPGPERQKFGVKTCFGNNYRMVWFCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPW4</accession>
    <name>A0AAV6TPW4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001483">
        <property type="protein sequence ID" value="KAG8173798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPW4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052160">
        <property type="entry name" value="Gypsy_RT_Integrase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47266">
        <property type="entry name" value="ENDONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="123" mass="14250" checksum="98C0CFFC9405986A" modified="2024-11-27" version="1">MDCAAWARQCIPCQKSKITRHSKTPLVNFSDQSQRFDHVHIDLVGPLPPSQGNYYVLTLIDRFTRWPEAVALPDMTAATVAKSFYNIWIVRYGCPLRITTDQGRQFRERAVLRIFKIIWNPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TR62</accession>
    <name>A0AAV6TR62_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001196">
        <property type="protein sequence ID" value="KAG8174510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TR62"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="157" mass="18072" checksum="22EFABC2258608D6" modified="2024-11-27" version="1">MYDFVAVAEFLFLQGVLVPLRVIFTSTRNPDKTILLEADADTLQMTYADVRKNLQMSPDIFTRHQQRPTTHHLTCHVNHLSSYLGGKFTQDYLKEAWHEPRIVCLHSATHNLLLGLMPNVTLLDGQLTYRQDNSLNFSLRAARSLNTKLGLEPYWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTI3</accession>
    <name>A0AAV6TTI3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001101">
        <property type="protein sequence ID" value="KAG8174974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTI3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="9417" checksum="E74C4D73CB77C194" modified="2024-11-27" version="1" fragment="single">CQPRTTTYAPLMYAEGARKVSDVNIEKDLKQRHNNRIPFGQIKLNYLSVRHVNSRPKHYYSFCLQTIFIKQIEYENLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTI9</accession>
    <name>A0AAV6TTI9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_021971</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001102">
        <property type="protein sequence ID" value="KAG8174973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTI9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000011">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043865655" description="EGF-like domain-containing protein" evidence="16">
        <location>
            <begin position="21"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="220"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="303"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="347"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="390"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="435"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="920"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="927"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="939"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="960"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="967"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="979"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8174973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1009" mass="111697" checksum="9D909983D45CE523" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTS1</accession>
    <name>A0AAV6TTS1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000996">
        <property type="protein sequence ID" value="KAG8175467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTS1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7261" checksum="F0C9A441BCC9DB3D" modified="2024-11-27" version="1">MKNWFSEAETVNSTALVSPVVTLSDAPSACSDELANAPVSLMPCVVFPSASSANPDPSLPQRHQPVCCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVE6</accession>
    <name>A0AAV6TVE6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000976">
        <property type="protein sequence ID" value="KAG8175641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVE6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043832072" evidence="1">
        <location>
            <begin position="20"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="28" mass="3074" checksum="0BB91D06D6EECD9B" modified="2024-11-27" version="1" fragment="single">MLLAASALILLLCCEEVKLQPIDQTTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVJ6</accession>
    <name>A0AAV6TVJ6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000996">
        <property type="protein sequence ID" value="KAG8175490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVJ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="88"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="170" mass="19513" checksum="55AB57437A22DF6E" modified="2024-11-27" version="1">MTQGRLPKSPKPWWNHDCSQAEKQKKSELGVFSVAILLRQIRLNSRGLGPMPVGYDVKAKALLKLYNRIWNEKVFPTSWQRAIVLPIAKPGMDPQDAGNYRPIALTSCLCKLMERMVDARLVYCLEEKGAFSPFQSGFRHHRSTIDNILLLETSIREAFVRNQHLVSIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVQ7</accession>
    <name>A0AAV6TVQ7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000948">
        <property type="protein sequence ID" value="KAG8175814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVQ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29849" checksum="95B656F629C33A35" modified="2024-11-27" version="1">MECVTNSKWGNQFLRTGENIRFCDWRFIHKARLNLCSLNAQRRSSHHEEIDKSCRRCGHHTENLHHVVSTCRPLLHLRTKRHDAVLDRLIKARRRGFRVMGRNQDVDGSSLRPDLVLTQGDTAILIDVAVPYENRLTAFANTRSDKAAIATTVLVPHLKFPRAAQDHVLNLCPLDSPVPVLARPPSVGAPRARHLCCDNLQVSQVLNLSPLDHPVPVLATQCSYSLASQCCAPSARHLCCAVLTTKCTKCPNQPVPVPATLCSSSLASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TW18</accession>
    <name>A0AAV6TW18_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">JTE90_016730</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000989">
        <property type="protein sequence ID" value="KAG8175531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000040">
        <property type="entry name" value="Putative tatD related deoxyribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF2">
        <property type="entry name" value="INACTIVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="24" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="17" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="23" id="KW-0407">Ion channel</keyword>
    <keyword evidence="20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="21 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="19" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="22" id="KW-1053">Target membrane</keyword>
    <keyword evidence="11" id="KW-0800">Toxin</keyword>
    <keyword evidence="13 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="919"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="988"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="527"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="585"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="27">
        <location>
            <begin position="835"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1318"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1533"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1618"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1538"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="1578"/>
            <end position="1588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAG8175531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1637" mass="183982" checksum="092535CF4E8DD8AA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXG6</accession>
    <name>A0AAV6TXG6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000886">
        <property type="protein sequence ID" value="KAG8176406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXG6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="85" mass="9696" checksum="DD49579635579616" modified="2024-11-27" version="1">MLKTALTKGFFRYPHGKAKHNLPGKPPKQATRYQCSLCDYGSNFSANDFWLSQLQLENKIYQADLCKQSFSSAPFVHMPRGGRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYP9</accession>
    <name>A0AAV6TYP9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_000486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000843">
        <property type="protein sequence ID" value="KAG8176901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYP9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043731147" evidence="2">
        <location>
            <begin position="21"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="253" mass="28081" checksum="5E8F78F2CE1EFD8D" modified="2024-11-27" version="1">MKNLFLVYTLTFILCSSVQARSSLFGNFLFGGSSDTTKRSSTLPQNADLFNNNLTNPVYSETEIDPMIINSTFDKEFVDLYSWNVSENIAVGENSSGFEDAATKQSVKKQLVDISSKPPPVTSQPRPTIEHIESQSVKNTVSGEVNVTSSPDDPEEVVLGTTKASIVTEDKTIFQKSLEWVENTYTLSILIPVAAGVLFATTCVITVALCRCVRRCCRRRRLRKKIMLPDSVKSLRASDRKRLLGDCSSDEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U050</accession>
    <name>A0AAV6U050_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Protein kinase C and casein kinase substrate in neurons protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_019378</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. May form heterooligomers with other PACSINs. Interacts (via SH3 domain) with DNM1, SYNJ1 and WASL. Interacts with TRPV4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000802">
        <property type="protein sequence ID" value="KAG8177213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U050"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07655">
        <property type="entry name" value="F-BAR_PACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11843">
        <property type="entry name" value="SH3_PACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000014">
        <property type="entry name" value="Kinase C and casein kinase substrate in neurons protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000009">
        <property type="entry name" value="Protein kinase C and casein kinase substrate in neurons 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF11">
        <property type="entry name" value="SYNDAPIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="17">
        <location>
            <begin position="9"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="415"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="363"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8177213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="54891" checksum="3D329A7201FEC688" modified="2024-11-27" version="1">MSHHSDDGMLIPCSDSFWEPGNYKKTTKRIEDGFRLSNDMITLIQERCEIEKVFAKSLRNWSKKWNELIEKGPEYGTTEAAWKSALVEADRRCDMHIRVKDRLVSDVVTQIKQWQKDNYHKSMMTLKERKEMDDAFKKAQKPWAKLLQKVNKCKSEYHTACKNERSAINQERNASSDTSLSPDQVKKLQDRVSKCKDEVQKTKERYEQALREINDYNAKYMEDMTVVFDKCQEFEEKRLEFFKEMLFGISSCLNISTDQELPQIYEEYRHSIQNADASKDLKWWSGNHGVGMAMNWPVFEDYSEEFRDIVGKNKKAPFPESGIMLVNQHRIGEDLPEYNPDFHNISKKEKKNHNDGNIILTNVHSNHAKNGNKEKNLSNRNSAISTNGGPDANPFDDDQEDWEDGSNEALVDNGEPGVPVKALYDYEGAEADELSFKAGEIFDKLEDEDEQGWCKGRKGGRVGLYPANYVVLATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0I4</accession>
    <name>A0AAV6U0I4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_023552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000818">
        <property type="protein sequence ID" value="KAG8177121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0I4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF0">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="218"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="390"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="596"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="779"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8177121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="869" mass="101196" checksum="1A6B2916990FCD62" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0Q3</accession>
    <name>A0AAV6U0Q3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_015732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000822">
        <property type="protein sequence ID" value="KAG8177080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0Q3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8177080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="130" mass="14550" checksum="C2603CAD8A7A5B1F" modified="2024-11-27" version="1">MSERPRTKNFTALEEEILLNSVGEFSHIIECRETSALKVGEKGRAWQRVAELFNSQSSVTKRHINQLKLKYKNVKANSRKRLANDKVETFVTGGGRKKILASETDARLKASGAVLRPLENVFDSACQEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1R2</accession>
    <name>A0AAV6U1R2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000700">
        <property type="protein sequence ID" value="KAG8178377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1R2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8227" checksum="B281D0176EC955BA" modified="2024-11-27" version="1">MLFIRILTLRRLNMSFSTKFLCIAFACIVLGLVAMDHVSAMPHLHGQQNNNGVIQMLVAGLIAKLLQENNGGFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2I3</accession>
    <name>A0AAV6U2I3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000709">
        <property type="protein sequence ID" value="KAG8178240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2I3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11109" checksum="DD208323D87A280F" modified="2024-11-27" version="1">MIRITLPRSNRTQDRKELLGGSCTNVDLEDSRREATLRALAAPPSPNHIERSEELFSVRARESTSLFLVPCPNRPLVYSNRPCVTGTNDYPIEQSPAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2N4</accession>
    <name>A0AAV6U2N4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000693">
        <property type="protein sequence ID" value="KAG8178470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2N4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF281">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="418" mass="47925" checksum="BD1F4CE967B3AA23" modified="2024-11-27" version="1">MGADINSLPHEVLVRIFQFYLELECQVNFFNYVSKVCRTWKEISRNSCFFETLDGSLPLSALVTLAKAGSLRLTKTLKFGKVTKDKSGHYKCIYSNMPRLKHIDLTNVCEKLNNRKEHPVFTELDGLCPELCELVLSPPDAHCKSKILGVVFEQMMKIRGPHFVHLDFSSVNICGKPTIFELVADNCPNLEELLAQNLKGTTLTHRFNTEKMQKKCPKLKTLRLGFPISFIRNAYKDPVGFPDLEIFTHPSRDDYFFRSSDLETLLCQSAKLKILDVRGCVLVSFEVLNSLPATDLEQIYLSWLNHLNYTGIIKIFQKWSHSLNIVDVSHIKDKAVNEMFSPQHLPNGLPNLEVLNVNNTSITVETLKVIIQQNPKLRYLNLESCHGLIRGTRQIHRSRSEIEKLLVKIEKFEEMDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2Y3</accession>
    <name>A0AAV6U2Y3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_005278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000700">
        <property type="protein sequence ID" value="KAG8178386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2Y3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043608162" evidence="2">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8178386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9656" checksum="632F1F243EC3B8C3" modified="2024-11-27" version="1">MRKFLILLAVSLLLSGCLLPPAEGYYHHGGGLVEMLAAGLIAGLLGQQNHHHEAHHHHHGHHHGHHHHGHHHHGHDHHGHHHHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3Y0</accession>
    <name>A0AAV6U3Y0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_022407</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000667">
        <property type="protein sequence ID" value="KAG8178776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3Y0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="14">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="223"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8178776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="330" mass="36769" checksum="78E7B3BCCAAFFCFB" modified="2024-11-27" version="1">MTGDAKSDVDIPLRENLVETAVNFLLNPSVKGKPDHPKTAFLKNKGLTDEEISVAFQRAHSQPELSPAQQQPVQQQSLTPHSQPYYLRPYSFWARLSSVSSSLIVIAVALYGLHRFYKLYIEPWLFGTKPKSDELKELITELSSSVAELKNSVSTLEVTVNSQKDQIDRVFLSEGTSYMPIPMAVADLKTEVGNLKSLLINRHQFPAVPKVASNISIPQWQLTDTDAKENNKESKSVEETTEDSTSSADDSSSSGEETSNVDQPQNNDWRKRVLETIDQITKTAEARRLNGDESQDPSVVDPSETDENGVRDVHNVDVLQDPSLICDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U414</accession>
    <name>A0AAV6U414_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">adenylate cyclase</fullName>
            <ecNumber evidence="4 16">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">JTE90_018812</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="18">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="18">Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 19">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="4 16"/>
    <dbReference type="EMBL" id="JAFNEN010000707">
        <property type="protein sequence ID" value="KAG8178265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U414"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000001">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000002">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032628">
        <property type="entry name" value="AC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030672">
        <property type="entry name" value="Adcy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009398">
        <property type="entry name" value="Adcy_conserved_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16214">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF06327">
        <property type="entry name" value="Adcy_cons_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039050">
        <property type="entry name" value="Ade_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 16" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 16 19" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 16 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="505"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="603"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="22">
        <location>
            <begin position="174"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="22">
        <location>
            <begin position="747"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="994"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="1000"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="179"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
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    <feature type="binding site" evidence="18">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
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        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="797"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="17">
        <location>
            <begin position="871"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="17">
        <location>
            <begin position="878"/>
            <end position="882"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="918"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR039050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR039050-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR039050-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG8178265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1037" mass="117586" checksum="FC4393F5853BD62B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7T5</accession>
    <name>A0AAV6U7T5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0598 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000585">
        <property type="protein sequence ID" value="KAG8180124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7T5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028108">
        <property type="entry name" value="DUF4505"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31449">
        <property type="entry name" value="UPF0598 PROTEIN C8ORF82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31449:SF3">
        <property type="entry name" value="UPF0598 PROTEIN C8ORF82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14956">
        <property type="entry name" value="DUF4505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="169" mass="19771" checksum="CACD6C98728EA55E" modified="2024-11-27" version="1">MLFLDDARIKNFTSCFKEKKFLAFFFRRIRLNTTGKYEKDFPFFSPCGNEKNFVRCDDLPIVFTHILEVKQGVKQVDYLSYGHTGDMLKVKFEPEKICMLPETGRVYHTGPEATGGVGLIKSSLAIDLSQNFLYKNKEDTHEMPTYFMWKDKKYSLTNEVVDHLRTLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8A0</accession>
    <name>A0AAV6U8A0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_016190</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000587">
        <property type="protein sequence ID" value="KAG8180063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8A0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="15">
        <location>
            <begin position="39"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="16">
        <location>
            <begin position="303"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="256"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8180063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="424" mass="44396" checksum="30E849AE38A3DB2E" modified="2024-11-27" version="1">MALRHLSHESHQAIVSTRPFTAIPFTGTKSIAEMALNEVVIISHARTPVGAFKGQLSSVSAADLGKFAIQGAIERAGIQKDAVQEVFMGCVLQAGVGQAPARQACLNAGLSLSTPCTTINKVCASGLKAIILGAQSIMLGQQDVVVAGGMESMSNAPYYLQRGDTPYGGVDLKDAVLCDGLTDAYANGHMGDCSEGIARKFDFSRQDQDNYAIQSYKRTIAAGESGVLESEIVPVVIPGKRGKPDTIINSDEEYKRVDFEKLLTLRPVFSKEGTITAANASSLSDGAAACVLTSKSYAEANNLKPLARILAFADAAIDPVDFPIAPSYAIPKILSKANVEKDDIALWELNEAFSVVGLANIKMLNLDPEKVNVHGGAVALGHPLGMSGARIVGRIVNSLQPMQKGIAAACNGGGGASAILVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8W3</accession>
    <name>A0AAV6U8W3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_027866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000586">
        <property type="protein sequence ID" value="KAG8180086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8W3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8180086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="170" mass="19699" checksum="8C5677CB59961312" modified="2024-11-27" version="1">MWCRSLSETLRLWETCRPGRNNQQPPNRAGRSRRNNQQQPNLAGRPRRNNQQQPNLAGLPGRNNQQQPDLRVRHEAVQFKLRQIPHFVSSSSACVEIPEAELDDTKCGICVTGAREYKENRRPVARTDCGHFFCIPCIYNWKKRSSNCLYCTQPTLPRRGARGLYLFHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAN1</accession>
    <name>A0AAV6UAN1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_025927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000518">
        <property type="protein sequence ID" value="KAG8181380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAN1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF2">
        <property type="entry name" value="ACYL-COA:LYSOPHOSPHATIDYLGLYCEROL ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="90"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8181380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="522" mass="60254" checksum="CB02AE4717C61267" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBE0</accession>
    <name>A0AAV6UBE0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000559">
        <property type="protein sequence ID" value="KAG8180556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBE0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9678" checksum="44CA121ACE761705" modified="2024-11-27" version="1">MQIGKASTYIKRPAMHTSRFVSNKVYGISPSRTNVGEHTKRASQQEVNDAKEARMDMRLPLLMYWEKLHPAMRSVENNDGICRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UC06</accession>
    <name>A0AAV6UC06_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_025930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000518">
        <property type="protein sequence ID" value="KAG8181383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UC06"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF1">
        <property type="entry name" value="MINIATURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="797"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="77"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8181383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="843" mass="94849" checksum="39D64A49DADAF87B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCE3</accession>
    <name>A0AAV6UCE3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_025925</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000518">
        <property type="protein sequence ID" value="KAG8181378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCE3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="220"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8181378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="442" mass="49377" checksum="4047CAE8CDCEDE4A" modified="2024-11-27" version="1" fragment="single">GQNQSGGGPGGSGSGGDKKDDKKKKKYEPPVPTRVGKKKKRTKGPEAASKLPLVTPHTRCRLKLLKLERIKDYLLMEEEFLRNQERLKPQEEKHEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDQLEPGCSVLLNHKVHAVVGVLSDDTDPMVTVMKLEKAPQETYADIGGLDQQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAVGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVVMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKRRIFLIHTARMTLAEDVNIDDLVMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFRKSKENVLYRKKEGTPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UD85</accession>
    <name>A0AAV6UD85_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_028184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000467">
        <property type="protein sequence ID" value="KAG8182340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UD85"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8182340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="567" mass="66552" checksum="F993AD03F0427DDE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UE36</accession>
    <name>A0AAV6UE36_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000484">
        <property type="protein sequence ID" value="KAG8182004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UE36"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="136" mass="15165" checksum="AA2C2541418EF610" modified="2024-11-27" version="1">MGEEPKSRIDGRARNVISFAGIGCTERCDWSEEHANQCLHANHGVMEKGLSFSSESLGVFELLSFRAGNKVRTVVVVCVYHESDDVSKLGNTFPQLQRLTQRGFVQQPPHSPHSIRNFSWDSKVPLSIPEKAGKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGU6</accession>
    <name>A0AAV6UGU6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_013428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000438">
        <property type="protein sequence ID" value="KAG8182979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGU6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF11">
        <property type="entry name" value="UNC93-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8182979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="322" mass="35924" checksum="E65A62198356B9E3" modified="2024-11-27" version="1">MTTVVEESFGKNPIINDSLEGNASSEISIEADSKQEIPGDDKKAIQKRSFWNLFVFSISYLLLFTGFWTLSTLQSTMNALEGIGDYSQAVIYVCSTVSCILLPTFMIGKFGCKNILLFGAVTCVLCMASNMFLRWDTLMVGAVLYGVANGPFIASQAFYIDEMATRFLTTVEGQSEFIMALFFGLFMFFGQSTQIWGNLISYYVLRSDRPAPSPLNSTDCGINFRPSVNDTNRNLDPPTENQRFLLVGIYVGMGCVAIFVLGIFLEPLRNDLQETKGCRTILDRLLSSFKFLRDPVRILLIPLSVYIGMEGPFYTNEVTQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGX0</accession>
    <name>A0AAV6UGX0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000416">
        <property type="protein sequence ID" value="KAG8183454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGX0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8488" checksum="B59F6EB518F40F8E" modified="2024-11-27" version="1">MWERGMEEIRDARTADADAPWSGIYDGDAGDAVSNPLTTAELFIGRRGRGGGAMQMRRRSITTAERDRTEEGEDAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHH6</accession>
    <name>A0AAV6UHH6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_003889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000414">
        <property type="protein sequence ID" value="KAG8183542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHH6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8183542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="9006" checksum="39E55F832A4E9BF1" modified="2024-11-27" version="1">MLPIPLQRDDAGGRVERRGRHKMADGEGDRPDPSPFRSRARKGALKKKNVICVKDHRFIPRFFKQPTFCSHCKDFIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJ72</accession>
    <name>A0AAV6UJ72_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000381">
        <property type="protein sequence ID" value="KAG8184251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJ72"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="14094" checksum="1A4505EC6D18E933" modified="2024-11-27" version="1">MPILSWAANPKRKFPSKVKSLPTAKTKETNEERRKRLNREKNARFRQRQRDLAAFSITAPLSVHSPVESEQSPTESFEERRKRLNRERSARYRERKRAAAAQLEIPTAQLENYYSNVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKJ8</accession>
    <name>A0AAV6UKJ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="13">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_019326</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="13"/>
    <dbReference type="EMBL" id="JAFNEN010000363">
        <property type="protein sequence ID" value="KAG8184722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKJ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000003">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21292">
        <property type="entry name" value="EME1-MUS81_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="181"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8184722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="449" mass="50898" checksum="B64AE6BC033E6C08" modified="2024-11-27" version="1">MEKSKHRIKKKYTSPNPLFVKWLTEWKQDAAEKGLKIQYTYGKALCSLKKYPLPLSTGKEAKMLEYFGDKICAMLDAKLLEWRKDNSSNSLSSSQSSTDTNGSSSSQSSLTSKLLATKIKPSSPRAPKNNGVQVKTVNVGRVNSVPRSLPVSKEVESNQQMDIDEIDRNTFYLFPGRFSVILCVDNCESVSGHGKSKKQFVSELQKSNVEYEVRNLHVGDFLWIAHDHSDPNKELVLDFIIERKRLDDLAHSIKDGRFREQKFRMKNCALRNPIYLVENCSGAKYLGLPESTLEQAMINTQICDGFLVKKTQGIKESVSYLTMMTKMITCKYQNLTLISGSRETVLRKSAASNTFMCFKDFNCSSLKNKSLTVKEMFAKHLMQFFGLSVDRAAAIVQHFKTPSEFLEAYDRCNSENEKIHLISSIKYGLHKKNIGPALSKTLLQYYSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKY7</accession>
    <name>A0AAV6UKY7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_001507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000360">
        <property type="protein sequence ID" value="KAG8184810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKY7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003834">
        <property type="term" value="F:beta-carotene 15,15'-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8184810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="533" mass="59879" checksum="915CAD362217FCBC" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULM3</accession>
    <name>A0AAV6ULM3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000372">
        <property type="protein sequence ID" value="KAG8184460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULM3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8754" checksum="60FAB4A1BDCE4B87" modified="2024-11-27" version="1">MDLQKEAAIWEQRLDDARDEGKQEGILIGHEKGREEGEKQAKIAVAKNLLKAGVSIDLIAESTCLPQARIAQLKEEISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULT9</accession>
    <name>A0AAV6ULT9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_014577</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000347">
        <property type="protein sequence ID" value="KAG8185102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULT9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="300"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="143"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8185102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="640" mass="72331" checksum="962257E018BDC515" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UM78</accession>
    <name>A0AAV6UM78_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_019359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000363">
        <property type="protein sequence ID" value="KAG8184763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UM78"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18727">
        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8184763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="766" mass="87690" checksum="2255E140743323A6" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UM97</accession>
    <name>A0AAV6UM97_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000363">
        <property type="protein sequence ID" value="KAG8184751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UM97"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="113" mass="13427" checksum="1FEFA049AC8C6F22" modified="2024-11-27" version="1">MAQLLPISVHECTGERERDGEREREGVRERKRGREREGERERERERGREREGERERGREREGERERPAKVTAHCHKRGLTTFKIYTLRSVCRKQRVGSGWEVTVNVPVSINFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNA7</accession>
    <name>A0AAV6UNA7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_025886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000343">
        <property type="protein sequence ID" value="KAG8185214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNA7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="entry name" value="MM3350-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012912">
        <property type="entry name" value="Plasmid_pRiA4b_Orf3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41878">
        <property type="entry name" value="LEXA REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41878:SF1">
        <property type="entry name" value="TNPR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07929">
        <property type="entry name" value="PRiA4_ORF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="MM3350-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8185214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="363" mass="42314" checksum="BF0278DB30E8F4CC" modified="2024-11-27" version="1">MGICFVPGCNHAANGTKRNCKYFFRFPTGEMLRKKWINNIRSDREPSEYSLVCSCHFKDEDRTNGPTIFIRTPGALQSINRPSTSGKRTACGQSTQTHTVAQYGRAIKPKHPSIRTKVDKSTQTEPSLHLQLCETTDKLERMHARIQTTDKFIKLACTGGIEYEDNDLETDMAEYASTVYQFKVSLQHIKPQIWRRFQVPADFSFKELHLAIQCVMGWQNYHLYMFRMGTKRIDIGNKFFPYIIDQDICVGNERDGDNIISASDTKLPRFFKKEKSRCVYEYDFGKSWMHDVVLERILPRKEEDILPRCLNGKRNCPPEDGIYSSDSEDDDDKTRAWKKKRRDPEFFDLNAVKFNFKNIDNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQU7</accession>
    <name>A0AAV6UQU7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrokinin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000308">
        <property type="protein sequence ID" value="KAG8186257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQU7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043798351" description="Pyrokinin" evidence="2">
        <location>
            <begin position="28"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8186257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33373" checksum="D39BD27886268504" modified="2024-11-27" version="1">MLRSAKCPVILWCKFAMVSVLLQNSLGLDISDDENHQALVQLARLEKPGFWTFVEDSNSQANGVIPFARLGRKLFKLPQTLIPYPRTGRELFDTDIFDSDDSLMSDYSWHNLADGPMADFFLDGKSLIPKRAIAAFPPRFGRKKRSLSAEDEQMEQDDSERAQDKDSRSPSRNWFNLGDFETDMFLRQDRKPKSKNSFVPRVGKRQFDRGMDEIPENNKRAKIFQPRVGRIPSSMFSRMESDNPRGLFQVKSRGAFIPRVGRRASFVPRMGKKAKFSPRVGRRSEDVDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UR56</accession>
    <name>A0AAV6UR56_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptor Mth2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_027080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000313">
        <property type="protein sequence ID" value="KAG8186086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UR56"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043731159" description="G-protein coupled receptor Mth2" evidence="6">
        <location>
            <begin position="22"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="593"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8186086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="763" mass="86991" checksum="74EA7185314FF9ED" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URC3</accession>
    <name>A0AAV6URC3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000291">
        <property type="protein sequence ID" value="KAG8186749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URC3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7880" checksum="2103AC7F71180B4D" modified="2024-11-27" version="1">MQFAVNEEKHIPAMLRSCHLTSILRKCSLHLDTDFGGSYSPSTAGIQTGPLRRRKEENRRHGLALSEICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USI8</accession>
    <name>A0AAV6USI8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000275">
        <property type="protein sequence ID" value="KAG8187272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USI8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032055">
        <property type="entry name" value="TMEM72"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28474">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28474:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16054">
        <property type="entry name" value="TMEM72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="184" mass="21813" checksum="03D9B90871D1A52D" modified="2024-11-27" version="1">MDRNKPSVLLRALEFVEVTTRLWGIITMIVMWGVGIDLTIHKHGLGEYTLFIAVILTIFETSFAINIFLDFIIKDDKNLCFQFWQLLQWFDMWKKTVLYFFLSIFCFIKPHEMWLGTIGGTMLIVLSLLYIIFTYKMHLIEQETLMFDKECSYDRFEDLQDEIDDRLPQINCGNVGDQDTILRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USZ2</accession>
    <name>A0AAV6USZ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_009531</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the activator 1 small subunits family. CTF18 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000272">
        <property type="protein sequence ID" value="KAG8187461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USZ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053016">
        <property type="entry name" value="CTF18-RFC_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="334"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8187461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="866" mass="99142" checksum="3F840CD16FED2587" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UT66</accession>
    <name>A0AAV6UT66_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000284">
        <property type="protein sequence ID" value="KAG8186928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UT66"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="124" mass="13223" checksum="387D41C1F4FFC8A3" modified="2024-11-27" version="1">MIIKVRCQKRQRKISDVTSISPRNPYLLSPMLSLAPVRSRSLKALLVPSELASLLPEPFLFHGVDVGGDGHVQLFAAAHSLPQCIAEVAKVPLAPSEPASLLAEPFLLHGVDIGGDLSVQLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUJ8</accession>
    <name>A0AAV6UUJ8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_009541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC149 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000272">
        <property type="protein sequence ID" value="KAG8187472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUJ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019179">
        <property type="entry name" value="CC149"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21682">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21682:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09789">
        <property type="entry name" value="CC149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8187472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="232" mass="27630" checksum="BAEB48A39B0DEBCC" modified="2024-11-27" version="1">MTLKFQKLEEDYLSLLTEFNTTKCKLECKTDSLLILSQELEKCRLEKDQYKLMADQLRTRYSALKRRVEGWGPSLIGVYDVDGLKCEREKSLVQMLVELKDRNKMLKYENMDLKQRLEDTMGDIKILREEISKRNADCTQEFLSANYVPFSQKETLVKQLETQKLKWAQLTKDLESVLDEKEELITARDQYRHKFERLNQQMNYVLRGDQQKPVDIDGVLMDNKYLHDELNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVI4</accession>
    <name>A0AAV6UVI4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVI4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043395036" evidence="2">
        <location>
            <begin position="24"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8188490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="722" mass="84522" checksum="06ABE5CD2950E820" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UX12</accession>
    <name>A0AAV6UX12_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_019448</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000247">
        <property type="protein sequence ID" value="KAG8188169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UX12"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20344">
        <property type="entry name" value="BRcat_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20360">
        <property type="entry name" value="Rcat_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16773">
        <property type="entry name" value="RING-HC_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000004">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047555">
        <property type="entry name" value="BRcat_RBR_TRIAD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047556">
        <property type="entry name" value="Rcat_RBR_TRIAD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26000">
        <property type="entry name" value="UBA_ARIH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="111"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="423"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8188169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="469" mass="54241" checksum="8407E662DC30C964" modified="2024-11-27" version="1">MEEDDADYEDYYNTSEDPEMEVPQEEDPEQFDFECLATEDVERLFNECVEGVCAALPVKPSLAKLLLHTHAWNAKEITVLYTAGASKLLVDSRIKPANPPQTEAQSVRGCKSVSCSVCLLYYIGEHFRALACGHYFCKECWSTHFEIQINQGITTMMECMGQGCSLLVPEDFVLSILNKAILREKYQKFSFSDYVKSHPELRFCPGTNCSTIVLAKEPQSKRVTCKYCKVVFCFKCGSDYHAPTDCDTIKKWLTKCADDSETANYISANTKDCPKCSICIEKNGGCNHMQCYSCKFDFCWMCLLDWNSHGSEYYECSRYKENPNIANESAHAQAREALKKYLFYFERWENHARSLRLEEQTHQKIIDRINEKVMASEGTWIDWQYLRNAASLLAKCRYTLQYTYPFAYYMETGPRKALFEYQQAQLEAEIENLSWKIERAETTDRGELENQMDVAEKRRTTLLKDFLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UX23</accession>
    <name>A0AAV6UX23_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000258">
        <property type="protein sequence ID" value="KAG8187861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UX23"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="14513" checksum="0783B6D75D320CD7" modified="2024-11-27" version="1">MVRCEINFHLHKIRQKPLNTTYSLRRNIQQIRFLLFEKKRFQSVTPKVNIIPNQLQNQAFPKSKGTSHFHIHLPDIIPNNRGPDRQTNGIYKKKRNKKPPYAAEAAKSELIELLAHGGRVVVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UX90</accession>
    <name>A0AAV6UX90_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000222">
        <property type="protein sequence ID" value="KAG8189067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UX90"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8297" checksum="8053744F44E387B9" modified="2024-11-27" version="1">MRTLESGKQFSKWLLDVGNAKEGDAVKLPEICYPEIQDPIAQLYKDIDFRNVTSKQLKDRAILTVTNDIALET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZ77</accession>
    <name>A0AAV6UZ77_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_010061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000225">
        <property type="protein sequence ID" value="KAG8188968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZ77"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19338">
        <property type="entry name" value="Wnt_Wnt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009143">
        <property type="entry name" value="Wnt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF99">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043820811" description="Protein Wnt" evidence="10">
        <location>
            <begin position="21"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8188968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="354" mass="40191" checksum="C9BC83E7C06347BB" modified="2024-11-27" version="1">MTLAARGGYLLLLLLPLVRASWWLLGMPAAYQTSLELKPTTYQTYCRKLQYLGERQKELCGTSPNILQTVGRGAKMGIDECQHQFRMSRWNCTTFSNSSTVFGGIMDVRSREKAYIYAISAAGVAYSVTRACSKGELAECRCDEQVRKRDNGGRWKWGGCSDDIKFGARFSKDFVDSGENQQAPEGLMNVHNNEAGRRGLRSKMELVCKCHGVSGSCSMRVCWRRLKPFREIGDLLTSKFDGATLVKAVERRHKTKLRPVRKNVKRPSKKDLVFLDDSPDYCVRNETRIGVLGTKGRLCNDTSYGMDGCRLLCCGRGYQTVIREVEEKCQCKFVWCCKVHCEMCSFKKEEHYCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZY2</accession>
    <name>A0AAV6UZY2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major vault protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_000127</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000196">
        <property type="protein sequence ID" value="KAG8190032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZY2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08825">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000002">
        <property type="entry name" value="Major vault protein-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.570:FF:000002">
        <property type="entry name" value="Major vault protein-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.550:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.570:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000010">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.560">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.550">
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    <dbReference type="PANTHER" id="PTHR14165">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165:SF3">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="4"/>
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        </location>
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    <feature type="domain" description="Major vault protein repeat" evidence="11">
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            <begin position="558"/>
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        </location>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11978"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17794"/>
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        <source>
            <dbReference type="Pfam" id="PF17795"/>
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            <dbReference type="Pfam" id="PF17796"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="895" mass="100313" checksum="1E74326A0B75AB74" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1C9</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1V1</accession>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAG8189973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11804" checksum="4A817F7D5FF1BA1F" modified="2024-11-27" version="1">MRHSRIWALVQFKIFPTTSKAVYLLDHNFKAVYLLDHNFKAVYLLDHNFKAVYLLDHNFKAVYLLDHNFKAVYLLDHNFKAVYLLDHNFKAVYLLDSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAV6V209_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
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            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000202">
        <property type="protein sequence ID" value="KAG8189830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V209"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="144" mass="16236" checksum="46DE78B03D281A50" modified="2024-11-27" version="1">MSTHQSFSNQSTPGTTWPEWERIRLILDSLDAPENPPNEQSHAFFENNRRSEIAPRARFYAWKLGPRAELILTITSHLTTFPQNPKSTSLPLPLEITTNLDRIPHKSSSLPKTTHGAEKQTSGFMIFPAVITGKVALEMLRAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2X2</accession>
    <name>A0AAV6V2X2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009279</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000184">
        <property type="protein sequence ID" value="KAG8190442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2X2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24772" checksum="4F4BDD82D63DF6F9" modified="2024-11-27" version="1">MTFLERYHNVGDDFLSQVVTGDETWVAYVTPESKQQSMEWRHSDSSKQVKFKQTISARKIMCTVFWDRKGILLVDFLPRNETINAAAYCETLNNLRRSIQNKRRGKLSQGIVLLHDNARPHVANRTKDLITSFKWETLDHPPYSPDLAPSDYHLFLHLKKHLGGQRLQDDDEVKTVVMQRLTSQAADFYEEGIQKLVQRYDKCLNIGGNYVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3M8</accession>
    <name>A0AAV6V3M8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_006048</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3M8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="229"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8191295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="509" mass="58205" checksum="370B450C26BC688E" modified="2024-11-27" version="1">MERVRNFFRRINKFFRRRGSKKSKYEKENDNVLITNTESVKQRPNLAKELEIGQDYNYSAGDNKNIKVNQEETKISPEIIETLEFIIQQVESNISFQQEIPQQLEINLKDDQANENTTQIQEIVKLIEDIIQQVEHELDHPINKDQGSGIQGSTECVSNPKPPKSLEKATENLEPSNSLPPADPPRGLEEIKPSQTTATESRLEIIPSPIPKRTPKPWPEELEPLKDNYSYKGRLGKGGFGQVYKLRNKQTGEGVAAKVVPSNKVTVAETDVWPKLHHPTLLQFIEQHPFGKHHIFVSPRQKYRLIDVIYKAKFPKMKQYLLDALSGLEHLHRLGMCHLDVKPDNLLIGKHGAVWCDFGFVAESKGLTNASFLAPAAYRPPEASLSEGAEAKIPDGKAVDLWAFGVMLVELFTRFPLAHSKVKGNNWNKCFYPTLRKALSKKSFKKYFKKDFPLIDKNTCKALLDLIHAFLHKNPHNRMSAEEALKHPFFQDPVPKDFVKHEKDLSLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4V0</accession>
    <name>A0AAV6V4V0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_010822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000169">
        <property type="protein sequence ID" value="KAG8190959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4V0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12493">
        <property type="entry name" value="CUE DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12493:SF0">
        <property type="entry name" value="CUE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="7">
        <location>
            <begin position="173"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8190959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="306" mass="35240" checksum="CFD80EF57DCAD2A2" modified="2024-11-27" version="1">MSEHDSPEKNQDAFVKSELSRFIMEHTGSDTLSSIDEIVLSYIIGVLESLGSADVPEDVFDVDEFAEMMTAYIPAFSNIHSYHTYAWMLNLAGCLKEISRKNEKNKNCFSESFLFKVHERQRCVSESSTQSIDSESQTHSRTRRKSYHSSTSYSSSQSEDDEKCITVDNFGHDEIETLTEMFPHLHIVEVKQFLSMSDGDCEKAVQFILQRQESNLDLNEPVNLKGAVPTLLTASKEKVVEDKELRKQILKRYAYIDQDEDEREHKPVAPKTEPKKLIRYRDNKIVSIKGERYVEMKKLEDSDISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6L0</accession>
    <name>A0AAV6V6L0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SPOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_020735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000159">
        <property type="protein sequence ID" value="KAG8191488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6L0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010912">
        <property type="entry name" value="SPOC_met"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50917">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SPOC" evidence="5">
        <location>
            <begin position="10"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8191488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="261" mass="31097" checksum="5ABEE2054F8579D1" modified="2024-11-27" version="1">MAEAQENRTEEHMLQGRPVVWRGDLQLRFRHVPIQLHILSGNRALAERCFPQEELEVLQMSRTIRVCGLRMDEITRKTRKYVEHAILIGMAEADEEKGFLDELRRAQILKNNFMEYFYCKRSVGFLRLFDKDDDQYELHVFPHCAFSSEYLMRLVPEDWPRLQHSAYLLFFLTKKSSREPSPTTWLGDQLPNESQNRLEDPDGPNPNSEQQSQASRQHQEHDYSHFSFSETQPQEHDYSHFSFSETQPQEHDYSYFSFSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V831</accession>
    <name>A0AAV6V831_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_029116</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000140">
        <property type="protein sequence ID" value="KAG8192392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V831"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000318">
        <property type="entry name" value="ATP-dependent RNA helicase DDX19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="190"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="387"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8192392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="543" mass="61133" checksum="02556987E88FA186" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8F6</accession>
    <name>A0AAV6V8F6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000135">
        <property type="protein sequence ID" value="KAG8192772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8F6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7481" checksum="25F9AAC90EC9904A" modified="2024-11-27" version="1">MAITNKIKLSKERFLAKYGIKVSAHAVKRGLSTRGAGIEHDGRKTIVRRSVHRVSALFSLDKNSPYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAV4</accession>
    <name>A0AAV6VAV4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_019114</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000135">
        <property type="protein sequence ID" value="KAG8192796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAV4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000231">
        <property type="entry name" value="PLAG1 like zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000256">
        <property type="entry name" value="PLAG1 like zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF31">
        <property type="entry name" value="ZINC FINGER PROTEIN PLAGL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8192796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="406" mass="45814" checksum="DBCCC1C2F5046FCC" modified="2024-11-27" version="1">MSRQGLMRDTNGDGQQRDSVGTTSIQQQHYGYENGFRKPRGARCSRNEGGGDGEGRPDKVYACMHSGCARTFSSNFKLSRHLLIHSGDRRFQCTSCDRRFHRKDHLKNHLQVHNPNKILHKCDKCQKTYCSPMSYRKHIALHAAESGDLVCRICGMLQPDREAILCHLKVHTNSRTLRGPSERKYPCKLCDRSFFTKKDVKRHLVVHTGKRDFVCKFCPQRFGRKDHLVRHTKKSHNGHSICTPPSNDSVRKYEAQQQQQQMSSQQQQTPNDHKMVVSSTQMNDMNGLMMLDQPSVLDPVVKPDPGYGVPHHPANLIQSGYALSPLSTGGENGQLGRFSSESSISQYLPMSPSYPTPIMSHHYLNMSTSSNILSDLLPPMSMAPSFTTLSLDVGNPPLPHFNQAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCK6</accession>
    <name>A0AAV6VCK6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">15-hydroxyprostaglandin dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="3">1.1.1.141</ecNumber>
            <ecNumber evidence="4">1.1.1.232</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eicosanoid/docosanoid dehydrogenase [NAD(+)]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prostaglandin dehydrogenase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">JTE90_005059</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78836"/>
            <dbReference type="ChEBI" id="CHEBI:90697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48641"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.232"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:23261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90866"/>
            <dbReference type="ChEBI" id="CHEBI:90867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H(+) = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:41596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78325"/>
            <dbReference type="ChEBI" id="CHEBI:78329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:41597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67026"/>
            <dbReference type="ChEBI" id="CHEBI:78311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41573"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>prostaglandin A1 + NAD(+) = 15-oxo-prostaglandin A1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41263"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57398"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:85072"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41264"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16477"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57397"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16478"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57400"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="1.1.1.141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:11877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>resolvin D1 + NAD(+) = 17-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:50129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>resolvin D1 + NAD(+) = 8-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50124"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132080"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50125"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>resolvin D2 + NAD(+) = 16-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:53589"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>resolvin D2 + NAD(+) = 7-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137497"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:53585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>resolvin E1 + NAD(+) = 18-oxo-resolvin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:91000"/>
            <dbReference type="ChEBI" id="CHEBI:91001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:49245"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.141" evidence="3"/>
    <dbReference type="EC" id="1.1.1.232" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000115">
        <property type="protein sequence ID" value="KAG8193763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCK6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047034">
        <property type="term" value="F:15-hydroxyicosatetraenoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016404">
        <property type="term" value="F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000149">
        <property type="entry name" value="15-hydroxyprostaglandin dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG8193763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="245" mass="26788" checksum="C97218E08C67148B" modified="2024-11-27" version="1">MDFSGKVAIVTGGSQGIGLAFTSALLDHGMKVCICDIKSEPSEDYIKKLSEEKKSNLMFQKCDVTSFSDFNDAFEKVVAHFGRIDVVVNNAGIFIESDWKKMIEVNFIGVIHGIKLAFQFMNANNGGHGGIVINTGSNTSFEPLELGPVYSGCKHGVLGLTRSYGTDYHFAKTGVKVMAVCPGPVDTNLLHTYADFSIDRERAKEQLKEIKPIKPDAVAQALIEILQKGENGSLMRVDDQGMRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VD17</accession>
    <name>A0AAV6VD17_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000119">
        <property type="protein sequence ID" value="KAG8193546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VD17"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="445" mass="49132" checksum="23C50E03DBC3A909" modified="2024-11-27" version="1">MASIGRRLYRLFAICLPCLKSSEKGEKETEVKSFGSEEDKENKNRNGKEEKVHQEDEYPDSLNPFTSDDKEYEQENDYPQELNPFTDDEENEEKNDYPDELNPFANEEDDEAETEIVNQCSLELSPGLNSPAINGYSSTVPLPNEEKVDDGKNESEQQEDEYPDCLNPFAIEAEEKEQHDDDYPEELNPFADDKDEAADTAKANQRSPELAPELTPPAINGCPSKVPLLNDEKTEDGKDESKQQEYPDSLNPFASEDDENQYPEELNPFADDAADTAQVNQSSPELAELTLPAINGSSATSPLADKRKKAKSFKKRRAPDPPVIERVVPNEESAPGASKTLGSLPIIYKVKDYDEALNRFASEDEEATGDTTGKQSSLAQPTAATIDGCSSLNVSSKGKNKGKSSKKRHAPDPPGIESKDSAYSDIKSNQSKASSFHPCTEKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VD26</accession>
    <name>A0AAV6VD26_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000114">
        <property type="protein sequence ID" value="KAG8193828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VD26"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="108" mass="12426" checksum="124BD11DF16001E2" modified="2024-11-27" version="1">MGNWVTFVHGSFKKDDIVSFFAKRFPDLMYSLVVVCFSLAHRAYKNNDATPSEFKDVMQIAIWVFQNPQFRILAIPNASYPGAVKQNRVKLTSQRSAMAQMRFQCDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEH0</accession>
    <name>A0AAV6VEH0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000103">
        <property type="protein sequence ID" value="KAG8194453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEH0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="11117" checksum="7594A127840CADFE" modified="2024-11-27" version="1">MTSRSETIQIQKTMHPEDDPHPKRSNQKTIPIQKTIRSETINNHPQLNAKSTTLKFINNSDPLNVVAFQPSNIKEKCIISVIQDDMYFIPLINACQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF60</accession>
    <name>A0AAV6VF60_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000106">
        <property type="protein sequence ID" value="KAG8194276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VF60"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8461" checksum="903CA73268E96113" modified="2024-11-27" version="1">MIRRKAKASKKMPWMRKTAVNDPQLPFISHVPAGMRRRGTPHTSTNQMAGNSPDHGTMRCSGCGRVQESEGRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFZ3</accession>
    <name>A0AAV6VFZ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000095">
        <property type="protein sequence ID" value="KAG8194976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFZ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7669" checksum="0D11BA70726A2825" modified="2024-11-27" version="1">MWNPAWNKRATTSAAKKRNLVPLNFPTGGRGLMSSSSHGEVKTAWWTGGWIIIYNCFITGFRHCGDGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGK6</accession>
    <name>A0AAV6VGK6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000078">
        <property type="protein sequence ID" value="KAG8195809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGK6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="530" mass="59918" checksum="22CA9750CE57F5DD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIU5</accession>
    <name>A0AAV6VIU5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000064">
        <property type="protein sequence ID" value="KAG8196722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIU5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="142" mass="15951" checksum="E65DAE4C2E70E79A" modified="2024-11-27" version="1">MLSIGCYRRTETQEKQFIEKYCSPAANQLNTESTAIRFLPNLMRLYRIISQNLSAPTRTWTSGLSADFESAISENFCEKASSIQLSGTANGAPEIISVTKTSNLILYPLFLFLRSTDTTSYNLLLAFSMSELGFVLSKHTEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VK52</accession>
    <name>A0AAV6VK52_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_029006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000075">
        <property type="protein sequence ID" value="KAG8196036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VK52"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8196036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10806" checksum="273A772B72510116" modified="2024-11-27" version="1">MTKLFEWLSGVALITSIWFYSLHNDFILKKHDLHSWLLPVYGVVAFGIYSLLIILYRVFTFNDCKDAAEELKLEIKMAKEDLGRKGFKFDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VK96</accession>
    <name>A0AAV6VK96_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_014149</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000067">
        <property type="protein sequence ID" value="KAG8196588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VK96"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF352">
        <property type="entry name" value="BCDNA.GH04802-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="172"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8196588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="274" mass="30600" checksum="6FE4F7569B937D3A" modified="2024-11-27" version="1">MSIFHHSLEKAQLIVLGKHIQEGPKACAKSISGLLCYGNIAPKTNWGKLVTIVYAIFGIPLMFLYLTNIGNILAKSFKFVYGRLCYRKRLGDHRRRRQQTSLEQYQIHHIMLQDASATSPNAAANSIMDSSTLIRNKLNSDHVRDDMDDESLSPNYNRKPRVTVPITLCLAIIAGYICGGAALFSFWEGWDYLDGSYFCFVTLSTIGFGDLVPGDSVVSDEGTQEKLVICSLYLLTGMALIAMCFNLVQEEVVFKLRRLGRAVGLLTDREDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VL97</accession>
    <name>A0AAV6VL97_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_006583</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000066">
        <property type="protein sequence ID" value="KAG8196674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VL97"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="1 8" id="KW-0768">Sushi</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043753500" description="Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" evidence="11">
        <location>
            <begin position="17"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="12">
        <location>
            <begin position="238"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="359"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="417"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="477"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="617"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="623"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8196674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="77593" checksum="8CC2A2ADBA39C5BF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLM9</accession>
    <name>A0AAV6VLM9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">JTE90_027538</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O</text>
            <dbReference type="Rhea" id="RHEA:51312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:134022"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:51313"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:51314"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O</text>
            <dbReference type="Rhea" id="RHEA:51316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:133992"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:51318"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O</text>
            <dbReference type="Rhea" id="RHEA:51300"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:134020"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:51301"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:51302"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine</text>
            <dbReference type="Rhea" id="RHEA:64132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:77016"/>
            <dbReference type="ChEBI" id="CHEBI:149701"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:64133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:64108"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:59002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:64109"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:64110"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:64116"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:149697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:64117"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:64118"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-(9Z-octadecenoyl)-L-asparagine + H2O = L-asparagine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:64136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:149730"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:64137"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N-(9Z-octadecenoyl)-L-glutamine + H2O = L-glutamine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:51356"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:134033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:51357"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:51360"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:134035"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:51361"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:51362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>N-(9Z-octadecenoyl)-L-lysine + H2O = L-lysine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:64192"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:149731"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:64193"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N-(9Z-octadecenoyl)-L-methionine + H2O = (9Z)-octadecenoate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:64144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:149732"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:64145"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N-(9Z-octadecenoyl)-L-serine + H2O = L-serine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:51352"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:134031"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:51353"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N-(9Z-octadecenoyl)-L-tryptophan + H2O = L-tryptophan + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:64176"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:149733"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:64177"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-(9Z-octadecenoyl)-L-tyrosine + H2O = L-tyrosine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:64184"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:149734"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:64185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N-hexadecanoyl-L-phenylalanine + H2O = hexadecanoate + L-phenylalanine</text>
            <dbReference type="Rhea" id="RHEA:64124"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:149699"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:64125"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-octadecanoyl-L-phenylalanine + H2O = octadecanoate + L-phenylalanine</text>
            <dbReference type="Rhea" id="RHEA:64128"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:149700"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:64129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>an N-acyl-L-amino acid + H2O = an L-alpha-amino acid + a carboxylate</text>
            <dbReference type="Rhea" id="RHEA:15565"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="EC" id="3.5.1.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:15566"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:15567"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate</text>
            <dbReference type="Rhea" id="RHEA:54184"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:84824"/>
            <dbReference type="ChEBI" id="CHEBI:138093"/>
            <dbReference type="EC" id="3.5.1.114"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:54185"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:54186"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="28">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="28">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLM9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990845">
        <property type="term" value="P:adaptive thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.900:FF:000003">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000027">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036696">
        <property type="entry name" value="ACY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 28" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 28" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="29">
        <location>
            <begin position="246"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="27">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="27">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00049457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KAG8196824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="505" mass="56990" checksum="291383F5C9B02894" modified="2024-11-27" version="1">MPKIVRMFCKISLLLTIFVVILVSIAVLRALFLSKESVPETCTSEDNDYISDSRGLSKRLSEALKFETVSYAKHKYNEKALAEYLNFLNQSFPLVHSSQLVTREIVNNFSVLYHVQGSNEKLKPYLLAGHMDVVPVEEQHWEFPPFGGQIKDGFIYGRGTIDCKHIVMGVLEAVEYLLEKGHRPQRSFYMAFGHDEEVQGLDGAKQISKLLKLRNVKLEYILDEGSFVMENAIAGLNLPIGLISVSEKGHLDLKLEVQDQPGHSSMPRKETAIVILAKALSKLEGNVFPSMFGSGPEIAMLEEMAYCPVPFPFKVVIGNMWLFKPIIPFFLTSPAMSAIHRTTTAVTVVSGGNKVNVLPSSASASVNLRVHPAQTIQEAMDFVIKIVNDERVKVTKTVYTDPHPISPFDTFGYSQIKKSIMQIYNNTCVVPNLLIANTDTRWYLDLTKSIYRFSLVRMPLTEVHRFHGHNERIGVENYVNVVNFFLHLIKNSDTEIPSKHFHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPC3</accession>
    <name>A0AAV6VPC3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPC3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="11013" checksum="3D56BF1A46EAAD26" modified="2024-11-27" version="1">MWRTNSQNLGESRSHEVSVLGYVAVCIDTFSGICTMPSRHFRTTLLSALKLLENCILHAQKPAIWFVPSSLASAPLSWQQQRLLWDDHFLDTTPNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRZ4</accession>
    <name>A0AAV6VRZ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRZ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="35"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="290" mass="33403" checksum="77B420670149E74E" modified="2024-11-27" version="1">MVVEGPESFTNERWQKNVRSLKGGLAYICQTSALSDITMLVGSKKFKGHKLILKIRSEKFSKMFNKEEGNRATMEEIRITDVGEQAFEILFNYIYTSKIGDLDVNSRELVLEVHRAASVYGQHGLREACEAIIDKWEISHETVISVLQMSDVQIVIDRCWKHLQLYAREVLASNGILEATDDTLCEIFERGYFNGVPVMELLTHIVRWASRLFPCQPDFERVREHLLVCNGAQQRCLMSWIGLQKLSLEQLGMVMNKYPKLINDSEFRMFFLYVTAPEDKKPALPSWIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS41</accession>
    <name>A0AAV6VS41_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000032">
        <property type="protein sequence ID" value="KAG8199078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VS41"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043574448" evidence="1">
        <location>
            <begin position="19"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="223" mass="24837" checksum="DE27AA5D822AED03" modified="2024-11-27" version="1">MLIFKSILLVTLGVFASATEDDVCDPKQPELCFSPSVHVDFPVSEEELDKICPFKCLSDFKNRCNDVEFPRQLQGLENVHDILVEACDKDSEFHKKLAINLACIKEVFVNHLNTCVPIVKEAIDEMSNHPDIEFNVDNISDDNDWSKYVCLSEALDLSCFVASSSVRCGEEAGEMVGAVLDQIGILNVLCPEDIREEVLAVVEIIKPFVELGVVAEEVLSKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTN8</accession>
    <name>A0AAV6VTN8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000031">
        <property type="protein sequence ID" value="KAG8199126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTN8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9595" checksum="49DD8441E7938A93" modified="2024-11-27" version="1">MGSSDISALLWREKMGKGWGILVGLRELVWRVPHDTTKFTTCHPIHFINRHFQTAPAWHIQEVVSDPRPDTPNLARAPLSPRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUV4</accession>
    <name>A0AAV6VUV4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUV4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7661" checksum="7167674CFD62C7FE" modified="2024-11-27" version="1">MAEKTFRGHEEDMLDPSSDTTGMPLMTPAEPTVDVATKVGYSCSYDRIHHLFFLFGSQGERHGNLIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVT2</accession>
    <name>A0AAV6VVT2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_024980</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SPT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000018">
        <property type="protein sequence ID" value="KAG8200198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVT2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000001">
        <property type="entry name" value="Transcription elongation factor SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="13">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8200198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="116" mass="13023" checksum="AB4D9BE4B22140E8" modified="2024-11-27" version="1">MSLESVPKDLRSLRACLLCSIIKSVDQFEFDGCDNCEEYLGLKNNRDLVYDCTSSNFDGMIALMGGEDSWVAKWQRISRNAKGVYAISICGRLPQGVIRELKSRGITYKSRDTSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVU0</accession>
    <name>A0AAV6VVU0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Counting factor associated protein D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_024992</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000018">
        <property type="protein sequence ID" value="KAG8200213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVU0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000087">
        <property type="entry name" value="Counting factor associated protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043630550" description="Counting factor associated protein D" evidence="7">
        <location>
            <begin position="18"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="248"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="331"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8200213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="61857" checksum="2763F82956C7879F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VW52</accession>
    <name>A0AAV6VW52_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VW52"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043350006" evidence="1">
        <location>
            <begin position="25"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="9164" checksum="2719F889F372C757" modified="2024-11-27" version="1">MKTTKIEFFVAFAVLFCLVKAIEGQRPPPKVYAKIKCERRVKNETLLEKCKSCVEQYSLRENPSKSEISKLYSLERYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWB3</accession>
    <name>A0AAV6VWB3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000009">
        <property type="protein sequence ID" value="KAG8201059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWB3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="114" mass="12809" checksum="92F353228489B3D8" modified="2024-11-27" version="1">MACWILAVGVRLPDYVLDTPVLLFGLTLKHTRPSFCNLSINSKASPTSIFRNSRRPENGHSQFICHRNYFGKAAASIGWVEATVYWVQVVGALKVMCKRNGKREVCSYFIQGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWR0</accession>
    <name>A0AAV6VWR0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_002724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000009">
        <property type="protein sequence ID" value="KAG8201049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWR0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000423">
        <property type="entry name" value="Putative inorganic phosphate cotransporter-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="33"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8201049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="512" mass="55988" checksum="BB152A35C7C4D83F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXP4</accession>
    <name>A0AAV6VXP4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_019859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000007">
        <property type="protein sequence ID" value="KAG8201220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXP4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8201220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="118" mass="13751" checksum="1BF441BFF0613D0A" modified="2024-11-27" version="1">MPEVALQHPWDKNPPGGPSAKSLMTAKCHRLRSSSMVPQRSHKQILLAFKTRRISEDNRSENMHLKKWRRCIIFTRNFISGSARGSVILSKYDVRKGIFWVLVKCVFIKAFIFFSWCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VY17</accession>
    <name>A0AAV6VY17_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone-lysine N-methyltransferase SETMAR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_011229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000004">
        <property type="protein sequence ID" value="KAG8201555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VY17"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="9">
        <location>
            <begin position="54"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="115"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8201555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31776" checksum="1130989E3FA2D75E" modified="2024-11-27" version="1">MPVYIEDISSGQENIKISFLNEVNSYEPPTTVSYTLNCVLTSESLAENFESISLPCHCKDDCTSDCTCSASQAYNSGKLSETYDHHFGKPIIECSDLCSCNENCRNKVAQFGIKFSLQVFQTHNRGFGVRTMEFIPKSSFVCEYAGEIIDDVEAQYRISKQAADDSNYIYVLKEHSCEDKCAHTIIDPTYVGNVGRYLNHSCSPNLISVPIRSNNMVPRICFFAKSDILPLQELSYNYGGECVSRTDSSTFCKDQQISRARKCLCLSSNCCGFLPFVFDNWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VY71</accession>
    <name>A0AAV6VY71_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VY71"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="133" mass="15149" checksum="F5B3E41D25BA6796" modified="2024-11-27" version="1">MQGIQHHRAVCAVAECLGQFDKVLVWSYFTLSNIVNFHCNQGYLVRLPNKKDNFRITSLPVILNSFSSFPTFAKIYPQNSIATLYRKRPMSDNGTPLDIGPLSVTDTEFHFNKGSLKEKTYRLWTLGTNSPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W009</accession>
    <name>A0AAV6W009_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W009"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="13493" checksum="11575FBF9C42699E" modified="2024-11-27" version="1">MSIGDPLHVSKVAWKVARNACRVTCRGQIGSISTRLYTNKHFEVESRESQNLHKTNLPSPQLKGHPNQIPQPLLKAKSPAPKILQMIILTKSDECETLMLQITSVIGHLVNQGLNSDSKVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W1B6</accession>
    <name>A0AAV6W1B6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Caspase Dronc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_024316</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W1B6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038001">
        <property type="entry name" value="Caspase_ICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="10">
        <location>
            <begin position="102"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="9">
        <location>
            <begin position="248"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038001-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8201446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="40840" checksum="7F6B3F981F87D168" modified="2024-11-27" version="1">MDHRSRNIILRNKANLELKIDLEQLKPHLVKHKIFSRAMLKDIFETRECDLYTELLTRGPDALGKFLRALNDAEYHEEAKILSPSETLRLQTRMCYKMISKPLGYCKIINNVKFDFNIMEERFGSDMDASELSRVFYEIGYEVFTEHNLTDYQMRESLEKFAANDWTKVDSCIIIILSHGDTSDNQDMIYGVNNIGISKMDIYEMFDNRHCKQLQDKPKIFIFQACRGVREDNGVKESTDATVVRPVKRPFMSDMLVVHSALPNHVSYRDFEKGTWFCQDLVQVLSSDYLNDPLETMLQRVDRKMGIRLSARNMKQVTHIDKYGLKADIYFCLNNLTELPEFYIPFNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W2H4</accession>
    <name>A0AAV6W2H4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000003">
        <property type="protein sequence ID" value="KAG8201661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W2H4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8139" checksum="52111089C14C1666" modified="2024-11-27" version="1">MLQRGEPKDPFEGLNDFSDWSPQTSKRLQGRRVIISVSNHPHDDVSPRRPALAACYNRDTPEDAKPKSGNGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W3S4</accession>
    <name>A0AAV6W3S4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DMAP1-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_010434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DIP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05905">
        <property type="entry name" value="Dip2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000001">
        <property type="entry name" value="DIP2 disco-interacting protein 2 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037337">
        <property type="entry name" value="Dip2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06464">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01137">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DMAP1-binding" evidence="3">
        <location>
            <begin position="45"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8202070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1597" mass="174611" checksum="85A5CB1750378AF4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCZ1</accession>
    <name>A0AAV6TCZ1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006605">
        <property type="protein sequence ID" value="KAG8155782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCZ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003882">
        <property type="entry name" value="Pistil_extensin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01218">
        <property type="entry name" value="PSTLEXTENSIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="867"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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            <end position="883"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="906"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="935"/>
        </location>
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            <begin position="936"/>
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        <location>
            <begin position="1094"/>
            <end position="1108"/>
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    </feature>
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            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1161" mass="116680" checksum="E4CE44D0E1AEE640" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAV6TDG6_9ARAC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="931172"/>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006611">
        <property type="protein sequence ID" value="KAG8155774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="123"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8155774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="180" mass="19511" checksum="783EC0B8EAE054E7" modified="2024-11-27" version="1">MGKRGIPNAADASAGLYLFIRRRAYSRPIDRRTLLESLGPCFKTGRLACFLDKLSLTGGDTCLLSVSRKWKYLALVGVTTRLGALPSNPTPRRIRSRIEPSSYGLAPNLGKQPRSRGLAQSPSPARSLLNATFPHLLGEEGIRRGASPGYSPLLRNPCAFFSPLLLCLKSGVISSDLRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDR1</accession>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8156022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="176" mass="18874" checksum="2A45FA87F8134C43" modified="2024-11-27" version="1" fragment="single">MGTDRHENYTISLGFSRANRGAPDTARDAVLLREQRPYLRTSRFQGHELLQRKDNSSPGPPSTSPSSVALPHLVPKGPISVSGLGNINPIPFRSAARQTRACLQSSRLSLEYLLLPPRSAPVAAPGGLTPGTFNARHRDPPTHCGVNLHEGSSAVAARYRPNAGASSIFRASCFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEZ8</accession>
    <name>A0AAV6TEZ8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028394</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005583">
        <property type="protein sequence ID" value="KAG8170379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEZ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7508" checksum="1476B8DCA3D12C4B" modified="2024-11-27" version="1">MTSRNGNVNQLNRRRISNAIPLSSSYLQTPMSSGYAPPLPVRRISPTSYGSRMGMGMGMGSYYSPYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TG14</accession>
    <name>A0AAV6TG14_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_008770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004962">
        <property type="protein sequence ID" value="KAG8170749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TG14"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF5">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 44 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="10">
        <location>
            <begin position="64"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8170749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="154" mass="17697" checksum="CBC47BA33099BBDE" modified="2024-11-27" version="1" fragment="single">NRNKSNQQIIEKFLNRIDNPVRVQASVRLIKDRTQSCLLNSLNGAHHARLGEYAVDLWKEKSMTDVLIVVQEKEFKAHKAVLACYSPYFSEVLVKPGFSDVHYLHLPNVTANAFGILLEFMYTGRLRVTCQELNEVYRSARKLGMKEAVKECIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGA0</accession>
    <name>A0AAV6TGA0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004794">
        <property type="protein sequence ID" value="KAG8170834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGA0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="248" mass="30018" checksum="71C083D7183B434A" modified="2024-11-27" version="1" fragment="single">EGRERRGGKEEEEEEEGGREREEKEVGEGGREGRRREGGEEERKGKRRRGKRGRGREEEEGEGRRRRRREKERERRKEREEEKERGREEKGRGRGRRRRRREREGERGGKEGKGEVGGEREEGEEKRKKKGRRERKEGRREEKKGRGEKEGEGREKKEKEGERRRERERKGGEEGGEEREEREEERREEERRRRGEEGEGRREEEERERKRERKRRRKEERERGEREEGKGGEGKGGRRGGERGEGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGZ6</accession>
    <name>A0AAV6TGZ6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004425">
        <property type="protein sequence ID" value="KAG8171099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGZ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7151" checksum="82FDC6681204BACA" modified="2024-11-27" version="1">MRGSIGALTGAFGSSPAPVLLTKVPTGALSPLSRPAFSQSGASPHLKFGIGFETFGPPKASNHFRLRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THS2</accession>
    <name>A0AAV6THS2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004004">
        <property type="protein sequence ID" value="KAG8171417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THS2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="59" mass="6222" checksum="96CB8BF3135D86F7" modified="2024-11-27" version="1" fragment="single">SLTCGSDRGLSLSPAAPPRAEEPSEAAVRVEAGGGEVKHRLTLLVLKAKSISTWKSQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THW7</accession>
    <name>A0AAV6THW7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003937">
        <property type="protein sequence ID" value="KAG8171462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THW7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9864" checksum="0C206DE70E867811" modified="2024-11-27" version="1" fragment="single">AVDPNKQSIIVELLLMKKQQHRQQQRLENIRRMIDIAETHKKKKLPVILIKDLYQTTSAEVAEELLQKVPTVTDDVDADSSICTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THZ8</accession>
    <name>A0AAV6THZ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003874">
        <property type="protein sequence ID" value="KAG8171525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THZ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="84081" checksum="4A4471CF39D06D7D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJ10</accession>
    <name>A0AAV6TJ10_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003648">
        <property type="protein sequence ID" value="KAG8171712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJ10"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043944420" evidence="1">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="111" mass="13157" checksum="ABDBFE5C7BFA97D7" modified="2024-11-27" version="1" fragment="single">MRMFHRSGLILCLAAVLVSAETGCPYPEDVYPCTCVKGQLYELTCDHVDDPHVLLRVFENSRRYTFDVFNLKRSTLQYIPHQIFDDIKMFYFLMFNVTLRNLFDEVPRRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJK3</accession>
    <name>A0AAV6TJK3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003736">
        <property type="protein sequence ID" value="KAG8171646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJK3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9690" checksum="1DFD075A29E9970D" modified="2024-11-27" version="1">MSSWSDVLARRDGFGTGWISITPRYSTPYPTSFAISRRSIWRASSPFGLLERSSVAGLKKQTTWLRQESLESMRNRSENGGSCRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKR1</accession>
    <name>A0AAV6TKR1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002809">
        <property type="protein sequence ID" value="KAG8172344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKR1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043372443" evidence="1">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="134" mass="15180" checksum="612CC72F4DECAEB3" modified="2024-11-27" version="1">MIGRVRRWNASLTYLLFWPESLVVEDLSAADWEENGIYARVSVGPAVCGSVIEMGRSATFHPFLVIPSACVAIKSASKVVGRRRQGSLVPTTSRDYPKLCCIRCVFFLNNIVPSENARFTLQRYRFACWKNWVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNM5</accession>
    <name>A0AAV6TNM5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001959">
        <property type="protein sequence ID" value="KAG8173238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNM5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043652877" evidence="1">
        <location>
            <begin position="26"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="223" mass="24287" checksum="A972508FCDF9D019" modified="2024-11-27" version="1">MVNSKNMGRLYWVFVLAVVIVSSSARPHKCEQRERSLADLDLAEDALNRAKLLIPNCEDENGVSNSSECSRKDKSLGIIQVALNLISDAKKTLPVCNKEPPTVVTTVEPLTTVTTVEPLTNVTSVEPLTNVTTVEPLTNVTRIEPLANVTSVEPLTNATSVEPLTNATRIEPLTNATTLNLPETTRRFLRWTARIAAADCTSACTAWLGGKSSRPDGLMEEWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TP71</accession>
    <name>A0AAV6TP71_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoacetyl-CoA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001568">
        <property type="protein sequence ID" value="KAG8173650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TP71"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="14017" checksum="3764221E71D8B965" modified="2024-11-27" version="1">MNGWIFAVDQLPEVRDCLCVSQYNKDLDERAVLFVKIREGHSFSIQLLNKIRETIAKELTIEHIPDVILETKDIPYNMNGKKMEIIVKKIINKIPHTTEAVINLESLDYYYNVPELQLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPH6</accession>
    <name>A0AAV6TPH6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001455">
        <property type="protein sequence ID" value="KAG8173880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPH6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="81955" checksum="1C368FFC3A6F103F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPK6</accession>
    <name>A0AAV6TPK6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_000017</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001506">
        <property type="protein sequence ID" value="KAG8173770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPK6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043608158" description="Reverse transcriptase RNase H-like domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="146"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8173770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="285" mass="32041" checksum="897EB870626218C0" modified="2024-11-27" version="1">MLMVIVLALAALLNSAVSLEVFGVHEEDAMDCGVYLTCDEDNDDIWEIFYHLGKKAREKAFEVINREFLKNDLEKDGTGIFCSYGEDKRRKFIATYGDTLYTFWGTVCDDENATYDLEECDKVDETITLLSALIKKKLDNKECGIKEVLVACDASPYGLGVVLSHPTPEGDRPIAFASRSLTKAEKNYSHLEKETLALVFGVTRFRNYLPGREFTLLTDHRPLLSLLSETKPVPTVAAARIQRWALTLAAYAYKIKFKPGKDHSNADAFSRLPVRENCQEPPQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPQ5</accession>
    <name>A0AAV6TPQ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_022798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001777">
        <property type="protein sequence ID" value="KAG8173431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPQ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF3">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="155"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8173431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="436" mass="50701" checksum="C65232820AC10DB7" modified="2024-11-27" version="1">MDSLDSDEFSADECTITCLPPDPGELTDEENVNENCLDEVEPVDVCGEVELTLKRHETPDASEKKIKSKKRKRCQPENHFSTDEEDLDKSQIQEIEPKKSTKKKKPIKLNDIRSKKLKKLQKNSYAWKKGDKLDPIPSEKAQILEETHPELASKTPYELFRMYFDSDIMNLILEETFRYAAQKNNTTFSLSEKLLEVFLGIILFSGYHSLPQEDLYWSNSEDCNLPFIQNAMSRQRFRDIKKFLHLCDNNSIDGSDKLAKVRCFIEMFCKKLQQFGTFAECLSVDEEMIPYTGRHSAKMYMRNKPIKFGYKLWILASSQGYPFNIQVYVGKEAAATDKIPLGTRVVLDLIECVENCRRHRLYADNFFSSLKLLEEMRKKKFRLSGTVRENRLQKCPLQDNKVLAKKERGASDYIITKDIGVVKWKDNKVVWLSIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSP0</accession>
    <name>A0AAV6TSP0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001118">
        <property type="protein sequence ID" value="KAG8174910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSP0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="420" mass="49128" checksum="143CA9F6A7C1D573" modified="2024-11-27" version="1">MDGRERNKLWALWAFYDPYPKDELFFRDCGPKHVRFSEESGLGLCAFNIYHCFMSDKRKAGKEDELNEMRIHHRHLLVAMKRDRVASFKAEWKSVAFRECMPAEDRGGPVRRQRDKLCVSMDSASHLMYAIAYVSGPRATCDGNKDATASGSHYWMFQELSSCAKLSLAALFEGGHATLVSKRHRVSNLANFYEHVERANKHWQVRLKHLAMPEKNCVLPLARGYEMSDTWAEDCPVVYVYGRAKYLKCVPELGKLEYDAWLRHQLRTGNHFWYGLRDEYYVLEYYQTRSCGRKEDILRVLSTTQGDLTESQKRGTAREAKAQKRIEALARQLVTTRKDVAKPQKRIVDREEKCHARIRHLEAELKSVAEERFRQSEERLRATEERLRAAEEQLRASHVDTFLDEEETEEREGHRRTNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSY3</accession>
    <name>A0AAV6TSY3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001069">
        <property type="protein sequence ID" value="KAG8175110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSY3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7880" checksum="BF9AC810D8F0ED35" modified="2024-11-27" version="1">MPIWWLSRWGSFCQQSPLSGGGVAHWPRTTCVVPPTPIKRGKKVVEEGIAGLILLVEMCIGSRRWKYKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTB5</accession>
    <name>A0AAV6TTB5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001048">
        <property type="protein sequence ID" value="KAG8175177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTB5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043529398" evidence="1">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="112" mass="12651" checksum="32091A441C93F3B5" modified="2024-11-27" version="1" fragment="single">MSFSLALALYTITYVDTITPPVPKPTQDVEKCPGFFPVYSEPPWYTLPFQIDGQKRLDSNSTNHYVFVKGGVVPQDACAGSEMDPIYPPPGPQLYQYFQKTNWFRNPSLSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTE0</accession>
    <name>A0AAV6TTE0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_006963</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001112">
        <property type="protein sequence ID" value="KAG8174929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTE0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8174929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="61194" checksum="6E27AB1ACD51EF92" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUB1</accession>
    <name>A0AAV6TUB1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000983">
        <property type="protein sequence ID" value="KAG8175567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUB1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="169" mass="17539" checksum="BA9D7E57B4CE15A9" modified="2024-11-27" version="1">MLATAFSKNSQASWSALFSWISARISSNSYNGKSSVSLVDASGVRAEEALSSSGAGVSSEGGMRELQGRRGDGDGLGGGVSFGGVVRVDGFFLQWDGLLARARGFSSADEGDPSSGGMWLGEWWSAPESLAVQLAAWKGAQGQSSSGHFRAGEIGEDRWSVSLILIGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUV6</accession>
    <name>A0AAV6TUV6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000996">
        <property type="protein sequence ID" value="KAG8175474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUV6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="104" mass="11800" checksum="AD49F016D24677B1" modified="2024-11-27" version="1">MAQPQCFLTGGPNSVYYRPDSPREICRSMNDWKMAIDKHIIAIEAHREFLANLSPLEVQNRDLTIKDLNYNVSMVLDLRKNWKLKGVALLLAAGSPTNGIPTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUX1</accession>
    <name>A0AAV6TUX1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001044">
        <property type="protein sequence ID" value="KAG8175250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUX1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="14245" checksum="9778E9DAC0BA0BF7" modified="2024-11-27" version="1">MPSLFKEKYPDLDVKYEFYLNYFQDNFSLRFGRPQVDTCIKCEECDAKIKSSSLGDAAKRDARAELTVNKRRAKQFYNKLQEVTKLCAEHEDTVALSFDFMPSSGYFLLEATLGELFWNKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVC9</accession>
    <name>A0AAV6TVC9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000928">
        <property type="protein sequence ID" value="KAG8176010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVC9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14000" checksum="0ACDF0DA3CF25417" modified="2024-11-27" version="1">MFSALEKNVEDAWDQFFDFANVYRKECVDDIIFTVPIEENVRRTHGYMKKFATTALENKKNITFERTCFGCNTTCPARTVFPLQSSKLAQEKTKAGCNTTCPTRTVFPLQSSKLAQEKIKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVL7</accession>
    <name>A0AAV6TVL7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000928">
        <property type="protein sequence ID" value="KAG8176005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVL7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="263" mass="30684" checksum="06CBD34F8FFFCF8C" modified="2024-11-27" version="1">MSASYASVSYDIFYQNNATLSLLKKNKKTCIVCQKCPANNPTIPLDVLSFHLTTAHLINCGHKCVYCFCKFQWRPPREVGMKVHTSYLTLVKHRYECLQNLLQVSSCVATQVEDACIRRPAIRHQLQTDSYFLLGKRKTPDWRLPVAKMLRIQTLDQKRKFTRHADAKMLRIQTLDKKWKFTRHASFQNNETRETTHEQASEVAKDEECKRLRKQLDETQDALQDAHQQLLCIQDLLQEIQEDLVEPSTNDTISWILKKMLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWK6</accession>
    <name>A0AAV6TWK6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_012402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000916">
        <property type="protein sequence ID" value="KAG8176149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWK6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="188"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8176149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="468" mass="52365" checksum="1CFC750ADB86CF2C" modified="2024-11-27" version="1">MTDPPRLATDGVSLNVANSIRYLGVEWDSHLRFTPHLSLTKERVGKLLNDVATAGKSLFHKDPGLLKEIYRGAIERVALYGVGAWGHRTKLKGFCDRLRQIQRDCGLVLTRSYRTVSTDATQILAGIVPLDLVARAEWCKFQVCGLKLPAFDLLGIEVNPKNFDFPIDLHLSHPVDRRSLGFCSRLPCGDGLEIFTDGSAINGAVGGAFVVCYYVLAIHRGLGRLDDRNSVYQAELTAIENACDWVNQNLRNTEVSLFSESRSGLQTIANPDNRCLIARSIIEHIEKAKVLHVKMKLNWVKAHVGITGNELVDAAAKEATELEHQNWAQKLPKSYLRRSLKIMALDLWQNRWNATTNGLVTKRFFPKVSTSRLICGRVAQLTTGHGRFPSYLQRFQFDIEGECWCGLGMGSSDHYLSNFTLLDIVKLRKKLKAINDPFTILTHKANQPVLNQIVLTISKLLPNPLTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXZ3</accession>
    <name>A0AAV6TXZ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000844">
        <property type="protein sequence ID" value="KAG8176887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXZ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8322" checksum="296DACF3C1C6F9A4" modified="2024-11-27" version="1">MLAHSSNKTSNDNAMLSSHVEYDEGYLHRCYTKQHALIPLIVKLHLSAVSFGQLFNVFILTQVLSIDGKYIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYQ5</accession>
    <name>A0AAV6TYQ5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000862">
        <property type="protein sequence ID" value="KAG8176612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYQ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="132" mass="14347" checksum="F3D1876AE63687C9" modified="2024-11-27" version="1">MWLESNTSTSEKKISAFAELPQNETGTDLSPNNNDFGLVHKNSLTSMVQPLICSECGMKGLAVNITKEIEVVCKSCKQLGLNGATSPKVEPTKQFLVNKKIVDSLLSIGKGSSSIDTFCMKMGMNPIDRKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYU2</accession>
    <name>A0AAV6TYU2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000849">
        <property type="protein sequence ID" value="KAG8176818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYU2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="301" mass="33568" checksum="3D711E996141402A" modified="2024-11-27" version="1">MPVRTFATSAGGTIVSKEPPLDAVIVTDTALPMTATMPTSKEEYVTRFWQCRKCYKVLEKRKCTRYEHKCWEIQCKGCKKYVGSDYQCYLPSKRPKSANDKLLIFDVETDQSSGDHVVNFVVSQYANEDEKVFKGYDALNQFCTLLFTKLHKGHGNDKSEVSFSLCKNPSSEDKPSQCPALPNQDGEDVIEDNNAVNGTSTQTDVKSTASLANGITPNAVFRISPLEVEEATHLLCKTVEFWKDITEVSLYCAEIKVPAFTKGSLPMMSECINLVDADKEKALKNATFLQSAYKSDLEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYV4</accession>
    <name>A0AAV6TYV4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000849">
        <property type="protein sequence ID" value="KAG8176733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYV4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="115" mass="12489" checksum="CAB57FB55ECD31A0" modified="2024-11-27" version="1">MDRNVALPLPVSNTSKNAEKQKIQSKRNYAKLPKPKKAKRFGRAADASEKAAQLLTSIISSTTSECSLPPSNKKYKPDGKTSVHKKQMVFLGNMAVGQRGSSQVTCSKNPIVSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1T5</accession>
    <name>A0AAV6U1T5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_000347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000764">
        <property type="protein sequence ID" value="KAG8177661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1T5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF129">
        <property type="entry name" value="LP15124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043921964" description="Peptidase S1 domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="547"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8177661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="813" mass="90730" checksum="84440C1DF734EED3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U210</accession>
    <name>A0AAV6U210_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BUD13 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_020829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000716">
        <property type="protein sequence ID" value="KAG8178124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U210"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8178124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="509" mass="58694" checksum="26E2D1F8E7F98690" modified="2024-11-27" version="1">MMAANTSNSKTEYLKRYLGGEKKEKRKKKPKPSSSSLVPRIKIVDKNIDVKAIKFGDEVDVEEDEAPVVAEVIDDRPEEVKLKEVFDSSRWKKLDSASEDEHLRNLSNSSQKRTHSDDNSPRQNKHSRKRMDSDSDCSPPRISRNSHNKKLSRHDSGSDLSPPRNSKRLSKGSNRHDSGSDLSPPRQGHKSRNLKNVTKHNSDSDISPPRRNNTSQRSKVVKRHDSDESPPRRNDASRGSRDRNQSYKVDSSKRKVRNDSDSDLSPERQGPRKESSKKSRGSDSDLSPPRKNSGRGINLRDEKMRPSKTLSGLKAGLQNAETLRLETNELRHREKEQIEKLGAELSGRDARTVVRDRKTGKRRDLEEEDREKEEKERRLSEQQKKYSEWGKGIEQSEKQKSKFSEDLYEMSKPMARHRDDDDLEEMLKARIDAEDPMAEYMLKKRKQNDAARMPEYSGPPPPPNRFGIKPGYRWDGVDRSNGFERKYFEKINSSKATEEEAYLWSVQDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2W3</accession>
    <name>A0AAV6U2W3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Synaptotagmin-like protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_023251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000685">
        <property type="protein sequence ID" value="KAG8178560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:exocytic vesicle"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:exocytosis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FYVE_Slp3_4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Synaptotagmin-like 5, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="FYVE_2"/>
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        <property type="entry name" value="Rab_BD"/>
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        <property type="entry name" value="SYTL1-5_C2B"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="BITESIZE, ISOFORM I"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02318">
        <property type="entry name" value="FYVE_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2DOMAIN"/>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RabBD" evidence="7">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
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        <location>
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            <end position="2614"/>
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    <feature type="domain" description="C2" evidence="6">
        <location>
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            <end position="2766"/>
        </location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="1627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1685"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="1906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="1971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="2220"/>
            <end position="2267"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2287"/>
            <end position="2307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2370"/>
            <end position="2446"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="46"/>
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            <end position="265"/>
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            <end position="459"/>
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        <location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8178560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2803" mass="312084" checksum="401503E1D0517247" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2X9</accession>
    <name>A0AAV6U2X9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphopantothenoylcysteine decarboxylase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">CoaC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_029297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the decarboxylation of the cysteine moiety of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine and this reaction forms part of the biosynthesis of coenzyme A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000702">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Flavin_trans-like"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00082063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8178343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="191" mass="21626" checksum="24408916AC2D156C" modified="2024-11-27" version="1">MEPVEKCHLLIGCTGSVASIKLPELLKLFLKQAIDGRHFEIKVIATKNAFHFIPTREMPTNVTVYSDEDEWTSWKIMSDPVLHIELRRWADVLLIAPLNANTMAKMANGLCDNLLTCTIRAWDRMKPLYFCPAMNTYMWDHPLTAKHVKELKGLGYTEIPCVAKRLACGDVGYGGMAEVGTIVNEVVRRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U337</accession>
    <name>A0AAV6U337_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_016118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000696">
        <property type="protein sequence ID" value="KAG8178446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U337"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF77">
        <property type="entry name" value="LD25952P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8178446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="280" mass="31295" checksum="CA27A0E051BDFB1F" modified="2024-11-27" version="1">MTTEEKFKSAVDVINSIPYDGTFEPSEEMMLKLYALEMQAKEGPCNIPKPYVWNVSARAKWSAWNDLGNMSNLTAMESYIEELTKVVETMSYNEKISKFMSLMGPFYELVSSDDADSQKDKTKSDEASAASTVLDSYHPPTILQIYNMSKKPQHSRSSSGSLSDISNFDLLSDLTGSESSPPNEKELSGHFKSKEVLKSHPSLTEKDILILAIINLQTSLEDILKKLDKLNSLAASANLRNLETTVENTQSGSWNLNFTGTAFALIWPVAVDLYFQAFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U382</accession>
    <name>A0AAV6U382_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_005404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EEIG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000690">
        <property type="protein sequence ID" value="KAG8178510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U382"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8178510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="361" mass="39656" checksum="EEAFA4DD1FF06F35" modified="2024-11-27" version="1">MSFMLKKKKYKFKVDLVLQEISAVSFANGILFAKIRLQDGGTFTEMSQKQEVKNNCVKWDRKFQFGCKMTANASTGVLEPCLCRISIRKEVRGGRSFEKLGYASLNLAEFAGAGLTTRRYLLEGYDSKHRQDNSMLHISIEMFLLAGDPCFKTPDVRAPLGDKPEIQLPADKKGEDYSGDSLASGSSGFGSLPRKQRPNLLCSDLVVGTPEERTKEEENAADFERGHSRNSSYASQHSKASGYGSLASHSRQSSAESGHHRNPSSSSTYGEMCLSGVPKPTDRKRPSKKQAAEEGRMDSTRVSAKEVINEVFEATNLETDESTESPGLVLIIKNDGTPALSSHAVPDCSAGHYDQLILSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3U6</accession>
    <name>A0AAV6U3U6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_014209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000680">
        <property type="protein sequence ID" value="KAG8178618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3U6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043989322" description="Peroxidase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8178618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44262" checksum="3063B24704C58466" modified="2024-11-27" version="1">MFWKSSLPNALKIVLFFFVTKTSADVETSTLSSDAVEEALLLADVALEEWKKKEFERQRIDRDFVDDDIAGIRHDYLLPCGSKSRYLESVQQRYEVASKLLIHSFDLSSDQVRSSVGGIEPRSRGRDLCSRSFNATCDPDSKYRTYDGSCNNLRNPLWGAAPSCYLRLVDPDYGDGISEKRRSTSGGPLPSPRTVSVKLHGELAQTIPNVTAMLTIWGQFLGHDLLLTPVTKGPKGEMLRCCPVRKNNHPQCDPIIIEPGDPFFAQFNVTCLHNVRSAACGTCALGPRQQVDEETVFIDASQLYGPNENISRSLRKFDGTGNLRFIKSKDGGELLSLSNNPKRDFCSFQNPKLDCFRSGKYIFFIRVSTFALTAKIKKEKLTFVDNWCSIDQKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U454</accession>
    <name>A0AAV6U454_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000670">
        <property type="protein sequence ID" value="KAG8178742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U454"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="108" mass="12402" checksum="4E0E2980CE122590" modified="2024-11-27" version="1">MQKKDIKACDFFAKHLKLDAKLLSCVSFLMRKLSQGHLATTPNPIAIQLGTSERVGLYKHHFLPLISIIWDFGSEERMRGHQPSWNKVILRHFANPTERDSIAYGLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4H6</accession>
    <name>A0AAV6U4H6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centromere protein X</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_000930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Heterodimer with CENPX, sometimes called MHF; this interaction stabilizes both partners. MHF heterodimers can assemble to form tetrameric structures. MHF also coassemble with CENPT-CENPW heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex. Forms a discrete complex with FANCM and CENPX, called FANCM-MHF; this interaction, probably mediated by direct binding between CENPS and FANCM, leads to synergistic activation of double-stranded DNA binding and strongly stimulates FANCM-mediated DNA remodeling. Recruited by FANCM to the Fanconi anemia (FA) core complex, which consists of CENPS, CENPX, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FAAP24 and FAAP100. The FA core complex associates with Bloom syndrome (BLM) complex, which consists of at least BLM, DNA topoisomerase 3-alpha (TOP3A), RMI1/BLAP75, RPA1/RPA70 and RPA2/RPA32. The super complex between FA and BLM is called BRAFT.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000699">
        <property type="protein sequence ID" value="KAG8178415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4H6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8178415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9755" checksum="49471A9DCB0E9772" modified="2024-11-27" version="1">MAETKNPDFLKVKCVEKLLKSKFKNSNTKISNDAVKLTSEVLKVFITECAARSAIQAKSEASEEIPLPPEVDNQHLEKILPQLLLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U953</accession>
    <name>A0AAV6U953_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_016384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000567">
        <property type="protein sequence ID" value="KAG8180353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U953"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="6">
        <location>
            <begin position="49"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="5">
        <location>
            <begin position="298"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8180353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="497" mass="55463" checksum="8C09BAE893A0C09E" modified="2024-11-27" version="1">MEATHVLGLEQEAPVPKSHKKKKDKRSLADIQHEETFAVEPSSKTNVLNSEDWPLLLKGVDKLNVKTKQFVPISNGCSPLNREITDHLNSGFINLDKPSNPSSHEVVAWIKRILNVPKTGHSGTLDPKVTGCLVVCIGRATRLVKSQQGAGKEYVCIFKLHNAVDDPCRVPRALETLTGALFQRPPLISAVKRQLRVRTIYEVKMNQYDNEKNLGIFWVSCEAGTYVRTMCVHLGLTLGVGGQMVELRRVRSGIQSEKQNLYTMHDVMDANYVYKNHNDENYLRRVVQPLEALLVTHKRIIVKDTAVNAICYGAKIMLPGVVQFEDNIVLNQEVVIMTTKGEAIALGIALMETSTIASCNHGLIAKIKRVVMERDTYPRRWGLGPTASLKKKMVKEGLLDKYGRPNESTPADWSEKYEGKVKVEPTESAVKTEMMSPVPKRAASPTSEASGDEASASKKKHKHKKQKHGSDAEEKTQSPEKEKRKKKKKKSSSSDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9G7</accession>
    <name>A0AAV6U9G7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000539">
        <property type="protein sequence ID" value="KAG8180982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9G7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="181" mass="20999" checksum="0FB3BBF6924AC360" modified="2024-11-27" version="1">MESVIAKRTPARDLLSVESKERVESEEKELESKEKQVGMHIGRIAYRLYFKARPYCDSEDEVALNVQNGCYIGDINHSVAFAKNFLPYVCLRNLSILSIWNILLLKHNGKSVAASILDCISQWNISKHQFIAGSFDGQYFNLSVPEYLNQHFAEEKDKTFFYDWDPMHKASLVDDHMRKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UA19</accession>
    <name>A0AAV6UA19_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000556">
        <property type="protein sequence ID" value="KAG8180678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UA19"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10252" checksum="FBE6508B87972D3E" modified="2024-11-27" version="1">MPEPESNIYNKNFTRTIILAIHEISPDVCISRQNTPILELQAYHFYTSTPHPSTSSPPLNPLHICNSISGTASEIQDLTENTSINNRITKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UB54</accession>
    <name>A0AAV6UB54_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Costars domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_028290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000498">
        <property type="protein sequence ID" value="KAG8181752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UB54"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1540">
        <property type="entry name" value="Costar domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026111">
        <property type="entry name" value="Abra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027817">
        <property type="entry name" value="Costars_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038095">
        <property type="entry name" value="Costars_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22739:SF7">
        <property type="entry name" value="EG:152A3.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22739">
        <property type="entry name" value="STRIATED MUSCLE ACTIVATOR OF RHO-DEPENDENT SIGNALING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14705">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01283">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Costars" evidence="2">
        <location>
            <begin position="113"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="216" mass="24415" checksum="93796A4A4D3831EB" modified="2024-11-27" version="1">MTLPTFQFNILVPPGVQSRFGLLIRYPSTYIPNHPLPEMSSPIKIYGNDALSSRVAAFQKKAEDHQSKQRRNPFSGSGHVSTMANQKWDKSDPRYGKPEEGSKTEKRGLAAGALIGNEIIFLCEMISQYGTHEEDGTVWITFGELFQIYVTISNKVVGLLLRARKQGLVHFEGEMLFQRRDDDVVITLLKPINEIRPERPPPKCKQVEQSDVLSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UB56</accession>
    <name>A0AAV6UB56_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000517">
        <property type="protein sequence ID" value="KAG8181399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UB56"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34231:SF6">
        <property type="entry name" value="AGAP006868-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34231">
        <property type="entry name" value="EXS-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043720030" evidence="2">
        <location>
            <begin position="26"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="784" mass="88399" checksum="8AE81DB4428E1834" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBR8</accession>
    <name>A0AAV6UBR8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase family domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000522">
        <property type="protein sequence ID" value="KAG8181293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBR8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.280">
        <property type="entry name" value="AF1531-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.320">
        <property type="entry name" value="Photosystem II 12 kDa extrinsic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051675">
        <property type="entry name" value="Endo/Exo/Phosphatase_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180:SF32">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="67634" checksum="C1388E7A3B5EC1D7" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCM2</accession>
    <name>A0AAV6UCM2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000519">
        <property type="protein sequence ID" value="KAG8181376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCM2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13288">
        <property type="entry name" value="PH_Ses"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000378">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF53">
        <property type="entry name" value="INOSITOL PHOSPHATASE INTERACTING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="17"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="268" mass="30447" checksum="9B76A393DFF190CA" modified="2024-11-27" version="1">MKINEKNLINFASSKSCIDREGWLGKRGEVNKNFQKRWFVLKGNLLFYFEKRDDKEPVGLIILEGCTVELAENEETYAFKLVFHGAGNRTYILCANSQDHMEQWMKALASASYDYVKLMVGELQRQLDEITELEKQASLAMPRHLVENSTNAKLPSNRSDGCLFGHTATGGRASRFNPFDKWKNDGNVEGGPSNAVMATASSEGDLLHHAASGRTKGSRQRYLFIELHEYYGQTFRRLFEEQKKKRAAAKPSTQQDLLSFSETNLISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFB6</accession>
    <name>A0AAV6UFB6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000466">
        <property type="protein sequence ID" value="KAG8182351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFB6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7887" checksum="C07BC1C34C1A1B6A" modified="2024-11-27" version="1">MRKIFDYLFIDIQMESEERAMLVSAATARSEEGMCKHSKTAWDRILQELRIPPGFAKRGNDTLGLEGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJY6</accession>
    <name>A0AAV6UJY6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tantalus-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_006866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000396">
        <property type="protein sequence ID" value="KAG8183941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJY6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028149">
        <property type="entry name" value="Tantalus-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15386">
        <property type="entry name" value="Tantalus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tantalus-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8183941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="197" mass="22166" checksum="376C98C815E3FF52" modified="2024-11-27" version="1">MSEIKKRTNKKLTVEELYQNKNFVPPKEKNLETIFEEPRKAKNGTDILTSVRKYRRYLHFDPTQGKIQKRKLKAKKCVCKMKTGKLKTRSTTKKKECDDISLYILQAIGDLSDSEMEQVDGDTKDNCTISAMNDSIVKDTAKQTTNLNVDSEPLETANDKSQNSEDCGKESLIESSSDAVPEETEPNDSASSSCIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKR8</accession>
    <name>A0AAV6UKR8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable ATP-dependent RNA helicase spindle-E</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_019337</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000363">
        <property type="protein sequence ID" value="KAG8184735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000081">
        <property type="entry name" value="Tudor domain containing 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF113">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="12" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="143"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="371"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="16">
        <location>
            <begin position="941"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8184735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1437" mass="163000" checksum="C5D94E41492F7F1F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UN61</accession>
    <name>A0AAV6UN61_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000327">
        <property type="protein sequence ID" value="KAG8185667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UN61"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="163" mass="18372" checksum="0DBFFEBBD6034257" modified="2024-11-27" version="1">MSRFNFILNWNLSTGQETVQTLTFVRPGSHGRVKNKRDVYTLQGCTLRRVKDGDFHNYSSYRNLHQFPTDARLARDLVILLRWSVEMTAGWAIGAGTTLGAPENTTTYLSGQNAFTFHEGNVAGERSVNYGKFVFASLTIRDAQRLASLTLFLGHFGTKMFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNW3</accession>
    <name>A0AAV6UNW3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_002018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000324">
        <property type="protein sequence ID" value="KAG8185792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNW3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043652892" evidence="2">
        <location>
            <begin position="21"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8185792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="118" mass="12722" checksum="E004873697BEEF15" modified="2024-11-27" version="1">MHYSFATLAVLAVFCVVVLASLMDTTEAMPHRHHHGNRGLEHLLAAVRELPTKKKMFSFAKIAVAAVISVVVLVSTMVPTTEAMPHHNHNQGFGGLEHLLAAGIIAKLFQNNNGGFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPL8</accession>
    <name>A0AAV6UPL8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Single domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_003191</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000312">
        <property type="protein sequence ID" value="KAG8186109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPL8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029277">
        <property type="entry name" value="SVWC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15430">
        <property type="entry name" value="SVWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01318">
        <property type="entry name" value="SVWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043832090" description="Single domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Single" evidence="4">
        <location>
            <begin position="32"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8186109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="96" mass="10324" checksum="BD3A2ACEDACDF7D2" modified="2024-11-27" version="1">MFFRVILLSAVLVCAVQAYTYRQHIDTSGGACVGSWGSIPVGGEGYDDEKCERISCSEGMRINAGCGTVGLPPECRLVKGRGHYPDCCPRPECPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPU4</accession>
    <name>A0AAV6UPU4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_009224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000300">
        <property type="protein sequence ID" value="KAG8186465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPU4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000021">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="9"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8186465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="275" mass="31179" checksum="609DCB81D2846F4F" modified="2024-11-27" version="1">MKTGSNLTSNDYGLDPEELASKFNSKTKLIIVNTPHNPLGKVFKREELLMIGDLCKKHDVIAVMDEVYEWIVYKGNEHIRMATLPDMWDRTITVGSAGKTFSVTGWKTGWAYGPQHLIRPLQLLHQNCIYTCPTPIQEAVAVGFETEIARLGQPDSYWRELAEMLEKKRNKMSKFLSDVGMAPVIPDGGYFMIADFSALGAKVNFDEETGTKDYKFVKWLSKNKKLQGIPPSAFYSDTDKHLAENLIRFCFIKEDSTLEQAEKIINDLKKTISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ54</accession>
    <name>A0AAV6UQ54_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP synthase F0 subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000326">
        <property type="protein sequence ID" value="KAG8185705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ54"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7983" checksum="E62F7034B10A4DEA" modified="2024-11-27" version="1">MELNDFYRNFCYSRSFKISTRHLVFGIYLCQLVVVCLQCYIDSTRLPTAKKKLPAKKMKSWETVLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ97</accession>
    <name>A0AAV6UQ97_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000319">
        <property type="protein sequence ID" value="KAG8185958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ97"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="38590" checksum="A7BFA8240930146C" modified="2024-11-27" version="1">MLDLLLKPLKDLMMESRVVRFRIILILWCAVVVLKLFTMSFMLWLKRYSQILQMQESTGKSVYLGMLTFCMIYFPNMGFALIECFVLYYCCLCWILKRAFKVYIDLLKNNLEGRRVLSYHSRITKAVSCVDAVNSQQLFWIFSLFLVVFFAQTYILMHETIDINEIIITGWSALLFFVAVMSAASVGESAESLKQYMSENDSKFEDNMFYRMSLKMDASDNQLTVWKMFILKKTYILMHDTVHMTEVILTAWSALLFSVTVVSAASVRESSESLKQYMSVNDLKFEDITFYRMNLKMAASDNQLTVWKMFILKKVTLINVAGALITYAVILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URD4</accession>
    <name>A0AAV6URD4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000286">
        <property type="protein sequence ID" value="KAG8186882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URD4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="314" mass="36370" checksum="098C694BEFE30903" modified="2024-11-27" version="1">MAEEFEKASKKRSVARQRTTKLITKIETLYNDETVDKNEKCEELNCLLDQLLEKKSTLKELDIKIEGLVSCDELEKDIISVEEYLEKIVRWEGKIKRFLKLEDETRALDSSILSANGGVSMQNDRSNTSNYNENAGESSLLNSEVEVLRDFENNLKYDNERYEVGLPFKGEVDLPNNFEVSKRRLNSLVSRFRRDPVLYENYKSVFEEQLMSGVIEQVDITKDDLVDRIYYAPHHPVIREKKESNRTRLRIVFDMSSKERGSLSLNDNLHSRPNLNPDLLTLLLKFRMNGIGIVADIGRAFLSIGLKEVDQRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URI3</accession>
    <name>A0AAV6URI3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_024109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000287">
        <property type="protein sequence ID" value="KAG8186865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URI3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000037">
        <property type="entry name" value="Gamma-tubulin complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="182"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="475"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8186865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="829" mass="96021" checksum="D4FA3CCBA339C4E7" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URL3</accession>
    <name>A0AAV6URL3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_004622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000307">
        <property type="protein sequence ID" value="KAG8186278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URL3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF16">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="10"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8186278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="587" mass="65314" checksum="365100A443BCB376" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URL8</accession>
    <name>A0AAV6URL8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_026778</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="JAFNEN010000304">
        <property type="protein sequence ID" value="KAG8186358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URL8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8186358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="467" mass="53314" checksum="A24A22863E6F2042" modified="2024-11-27" version="1">MLKYTVQGTHQVISNPVLGVNKTFSRRLPGENIRLIMASGEAKHKVAVIGAGAAGLCAGRHLLAEPDKFQFDIFEQQDGVGGTWRFSAHVGVDQYGLPVHSSMYKNLRTNLPKEVMAYPDFPFKDCEGKSFVHHTQVLEYLQDYAENYGLYQHIKFHKMIENISPVNPAADPFEWSVSFSDVVTKEKEIRIYDAVMVCNGHYSVPYFPEIKGLFEFKGTVIHSHDYREPQAFKDLRVVVLGAGASGVDIAIEVSSAAKEVILSHNTPPKTCPFPDNVRQQKGLESVDETSVTFLGGERYECDVLIICTGYLYHYPFFDKSCNVKIGDQKITPLYLHMFLIDFPTLAIWAVPKLIIPFPIYDQQVKVFLKFLKGLIHLPTKEEMRSHMERDFCRRKELGMKPRHAHVMPGQLQWDYDDELSKFGQIDPVPDSVRNLFRHVHHLRTLDLINYKNTNYNLVGDESFVQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USG9</accession>
    <name>A0AAV6USG9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000281">
        <property type="protein sequence ID" value="KAG8187054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USG9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="112" mass="12792" checksum="0A7E24CF4DC2AC7D" modified="2024-11-27" version="1">MICDNDSSEPFVETSPSVHAALSNRLHSFVLREFLFFVFMSPIRKEHFIPGSGNTPFPQVRCVRERVTEPGLIRHISHDFPTRPDLNFNLSPTNDASLVKPIHYLACHTQCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UT22</accession>
    <name>A0AAV6UT22_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytokine-like nuclear factor N-PAC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glyoxylate reductase 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_009809</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000292">
        <property type="protein sequence ID" value="KAG8186740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UT22"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="6">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8186740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="753" mass="86292" checksum="A997B4662AA35C5D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTZ3</accession>
    <name>A0AAV6UTZ3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_015658</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000293">
        <property type="protein sequence ID" value="KAG8186721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTZ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14427">
        <property type="entry name" value="UBA2_HR23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000254">
        <property type="entry name" value="UV excision repair protein Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.540:FF:000001">
        <property type="entry name" value="UV excision repair protein RAD23 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="158"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="326"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8186721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="370" mass="40560" checksum="25486CF74F5A8A15" modified="2024-11-27" version="1">MIITLKTLKQQTFQIEIEETESVRVFKEKIEALKGNEYPAHCQKLIYAGKILVDDMKMGDYDIDEKKFVVIMVTKPPTAEENVDKASSPTAAVASLTPSTKTETVNNTASTEVKSSVAENEAKPQTQVFAEDSESSIQSVNVEGLDISAAESTLVLGEDYEKMVSQIMEMGYERDDVETALRASFNNPDRAVEYLITGLQDLPAESEPQQQGTPSPGGIQSSNSISIPTDNDAEPLAFLRTQPQFQQMRQVIQQNPQLLNAVLQQIGQNNPQLLLLISQNQEDFVRMLNEPQGPASATSRAAQPVVPTGTSPLESSLGEATAQVSPQDRDAIERLKALGFPEYLVVQAYFACDKNENLAANFLLSQNADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUU6</accession>
    <name>A0AAV6UUU6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_025918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000267">
        <property type="protein sequence ID" value="KAG8187584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="741"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="813"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="913"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1163"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1326"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1390"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1628"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1886"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1993"/>
            <end position="2023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2087"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="521"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="751"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="776"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="913"/>
            <end position="926"/>
        </location>
    </feature>
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        <location>
            <begin position="956"/>
            <end position="966"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="984"/>
            <end position="1020"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1062"/>
        </location>
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        <location>
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            <end position="1103"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1127"/>
            <end position="1144"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1163"/>
            <end position="1188"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1362"/>
            <end position="1377"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1419"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1439"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1452"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1628"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1890"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2004"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2090"/>
            <end position="2121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8187584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2165" mass="238014" checksum="317F13CBF4782221" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UV49</accession>
    <name>A0AAV6UV49_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_009878</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000251">
        <property type="protein sequence ID" value="KAG8187999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UV49"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="23"/>
    </dbReference>
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        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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        <location>
            <begin position="20"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1079"/>
            <end position="1097"/>
        </location>
    </feature>
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        <location>
            <begin position="913"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8187999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1098" mass="124316" checksum="77B2221073552B4B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVG1</accession>
    <name>A0AAV6UVG1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock factor-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_025832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HSBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000259">
        <property type="protein sequence ID" value="KAG8187794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVG1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000002">
        <property type="entry name" value="Heat shock factor-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8187794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7973" checksum="B628FADE675FA74D" modified="2024-11-27" version="1">MPTGNTLPDPKSIHDLTQYVQSLLQQMQDKFQIMSDQILARIDDMGHRIDDLEKNIGDLMTQAGVEETDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYS0</accession>
    <name>A0AAV6UYS0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000234">
        <property type="protein sequence ID" value="KAG8188660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYS0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00010">
        <property type="entry name" value="tRNA translation"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="9951" checksum="D22F6D3475DDC1C7" modified="2024-11-27" version="1">MNIPWYPSEVAEINSYKKEERRENCLAWAREKKNMASTHCVVLFSLQQKICKTAIFVALVAQWIRHRSPKPGIAGSSPAEGTDNNFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZ66</accession>
    <name>A0AAV6UZ66_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_009174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000230">
        <property type="protein sequence ID" value="KAG8188780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZ66"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043496205" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="640"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="710"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="66"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8188780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="781" mass="88315" checksum="7A41CCF472DC7109" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZ78</accession>
    <name>A0AAV6UZ78_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_007187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000236">
        <property type="protein sequence ID" value="KAG8188581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZ78"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF27">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043451052" description="Protein sleepless" evidence="3">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8188581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14834" checksum="36CC06FAB5DBF292" modified="2024-11-27" version="1">MLFLTIFAAFLPATLAIKCYTCSWSPKDAPNRTAMCNDEQFEGNALAISDCENGCQTYVHMDRNGVIEQMRRSCLQPDETMTGNCVNEENKVFSSKRCTCNYNLCNSAASYVLANSVFLLLASTLVLHIRNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V054</accession>
    <name>A0AAV6V054_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">JTE90_028664</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Postsynapse</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the TANC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000221">
        <property type="protein sequence ID" value="KAG8189125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058018">
        <property type="entry name" value="AAA_lid_TANC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058056">
        <property type="entry name" value="WH_TANC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF55">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25520">
        <property type="entry name" value="AAA_lid_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WHD_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 20" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0770">Synapse</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="17" id="KW-1053">Target membrane</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="12 22" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="24">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="20">
        <location>
            <begin position="891"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="20">
        <location>
            <begin position="924"/>
            <end position="956"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="20">
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            <end position="1067"/>
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    <feature type="repeat" description="ANK" evidence="20">
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            <end position="1100"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="20">
        <location>
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            <end position="1132"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="20">
        <location>
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            <end position="1165"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="20">
        <location>
            <begin position="1166"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="22">
        <location>
            <begin position="1326"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
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            <begin position="227"/>
            <end position="240"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038259"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG8189125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1440" mass="159780" checksum="043E2DC652AB3507" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V119</accession>
    <name>A0AAV6V119_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026602</name>
    </gene>
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        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000212">
        <property type="protein sequence ID" value="KAG8189558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="270"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="310" mass="36313" checksum="5844BBEBDD0DAD1B" modified="2024-11-27" version="1">MLRALAGYFFGGPQQEEQLECETKEVNDWLVVNMPDQPQTNIELEEESNDMELDDIDDVLWCLSNWFSPEVTEKTTNLEDEEDIEPSITQVRFLYDQENEVQNFDILYNNNKENNGDSMVNLPNELDIFMNMAYNLDLRQLNDWPLMPFVETSRCGKNMDQIQLKKITDYLKETLPMSFFVPPTNSKCELLCLYEEGSSKPKELLQRLRERNGKKATKHGDVTCPPVYSKTYVNHRHPSQSPPKTDLLQKIKELEPEQKATQYAMKKNLSRGQINRQNKNYIYDTSTKKNRRKNLQRNPSGANNNRKCCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1D7</accession>
    <name>A0AAV6V1D7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000210">
        <property type="protein sequence ID" value="KAG8189620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000827092">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8125" checksum="4224FF27998E1A71" modified="2024-11-27" version="1">MFGLDKEAVLYQEAVYVTSPTSCIGDVPNHRRYESPCAGGVSSRNRMARDYLQPFSPYGRYYLKVTAQLGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3R3</accession>
    <name>A0AAV6V3R3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_016649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000165">
        <property type="protein sequence ID" value="KAG8191134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3R3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22107">
        <property type="entry name" value="F-box_FBXO38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042354">
        <property type="entry name" value="FBX38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14753">
        <property type="entry name" value="F-BOX ONLY PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14753:SF3">
        <property type="entry name" value="F-BOX ONLY PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8191134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1278" mass="145025" checksum="03839EFA3D154EF1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6Z1</accession>
    <name>A0AAV6V6Z1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000160">
        <property type="protein sequence ID" value="KAG8191411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6Z1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9572" checksum="AB411E5EBC956AFF" modified="2024-11-27" version="1">MFTVLFLKLKTTTFISQPLSPKNPIQTHQHSCPSGRLQSGAPPMKRASSKKAPMVSISDTFWTARPALGTDPTSLFPTCNGYQDRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V805</accession>
    <name>A0AAV6V805_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V805"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="7728" checksum="0AB2FD5149D07C78" modified="2024-11-27" version="1">MGVPNPPPSYVSFLPRPAHDAQGPTTLLPQDQVCLTLGRYRVGLDRGRVDLERTGLTRIGGVDDLGKRGSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VA12</accession>
    <name>A0AAV6VA12_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VA12"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="66" mass="7358" checksum="297335B37816945F" modified="2024-11-27" version="1">MNKKPSLRIIKLCLKVNGELTSITILLIMQSIGRWVFDRTKQLDQTQMVVGGNDAVLGTCSPKQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAK5</accession>
    <name>A0AAV6VAK5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_024027</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000116">
        <property type="protein sequence ID" value="KAG8193664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAK5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20811">
        <property type="entry name" value="C1_Raf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01816">
        <property type="entry name" value="RBD_RAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14062">
        <property type="entry name" value="STKc_Raf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000024">
        <property type="entry name" value="B-Raf proto-oncogene serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000004">
        <property type="entry name" value="B-Raf proto-oncogene serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000036">
        <property type="entry name" value="RAF proto-oncogene serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000259">
        <property type="entry name" value="Raf serine/threonine-protein kinase phl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF262">
        <property type="entry name" value="RAF HOMOLOG SERINE_THREONINE-PROTEIN KINASE RAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02196">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00455">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50898">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RBD" evidence="15">
        <location>
            <begin position="155"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="235"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="453"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="396"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="37"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8193664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="766" mass="86638" checksum="7A46EBD91A9ED542" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VB60</accession>
    <name>A0AAV6VB60_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Myosin tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_011484</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paramyosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000113">
        <property type="protein sequence ID" value="KAG8193932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VB60"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000035">
        <property type="entry name" value="Paramyosin, long form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF7">
        <property type="entry name" value="MYOSIN TAIL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="6" id="KW-0518">Myosin</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin tail" evidence="11">
        <location>
            <begin position="36"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="117"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="708"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8193932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="876" mass="102380" checksum="9AC82C9789ED378F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDD0</accession>
    <name>A0AAV6VDD0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3CxxC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_027989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000100">
        <property type="protein sequence ID" value="KAG8194674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDD0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031849">
        <property type="term" value="F:olfactory receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026096">
        <property type="entry name" value="R-trans_p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14402:SF10">
        <property type="entry name" value="3CXXC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14402">
        <property type="entry name" value="RECEPTOR TRANSPORTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13695">
        <property type="entry name" value="Zn_ribbon_3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="8">
        <location>
            <begin position="61"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8194674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="175" mass="20070" checksum="F9DFD71CAAD86AC9" modified="2024-11-27" version="1">MCSITTTPAVLAVPIVKRTCTEAVVWQVIFMKLFYRFVPHSWRLVSVPNRPSGRWHTFVDSAKVRFSCKSCEHGWTSMKGRITFWCAFSNNTGVVAYRLYGQQCGSCTGESYESAMWYPEEIEKVLWNICNRVAHVFYGLARPPIQLNRRPGKPKNPHNSEKCQACKDGVCAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF93</accession>
    <name>A0AAV6VF93_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_027994</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000100">
        <property type="protein sequence ID" value="KAG8194679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VF93"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF5">
        <property type="entry name" value="VENT HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="112"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="114"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8194679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="238" mass="26422" checksum="7008D12A50BDCA99" modified="2024-11-27" version="1">MFSDANSALVGAMLNSRMRSFLIRDILDEPQRDDISDKECEVVSHQGSRYNNGYDSTKDDPRSALTTPPNHTSHHPSFYGDPRSSPGGYSDGRSPQPSHPHKDVGGSASKAKKPRRRRTAFTQAQLAFLERKFRCQKYLSVADRGSVAEALSLTETQVKTWYQNRRTKWKRQNSQRLEHLRQQSQGISKEGPVGGLGTSGPHPLDGPLVSATYYGACVVPTSFAPGILRNVYVPGFQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFK1</accession>
    <name>A0AAV6VFK1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ferrochelatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_026383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000099">
        <property type="protein sequence ID" value="KAG8194735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFK1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000001">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8194735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22197" checksum="BF9F865EAC1EF6AE" modified="2024-11-27" version="1">MANILCFADLISKELELVPEEDRNDMILLFTAHALPMSAVNRGDPYAAEVAATVLGVMQKLNFSHSYRLVWQSKVGPVDWLSPQTDDAIKGYVSKGKKNLMLIPISFVNEHIETLHELDIEYGEELAHKIGVKNYRRVPAPNDHPSFIEGLADILKSHLKSEEVCNPQLLLRCPLCTKATCHHTKDWLSQLKQKGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VG47</accession>
    <name>A0AAV6VG47_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_028001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000100">
        <property type="protein sequence ID" value="KAG8194686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VG47"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8194686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="136" mass="15344" checksum="0B58ED279E767982" modified="2024-11-27" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASESYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIQ3</accession>
    <name>A0AAV6VIQ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000085">
        <property type="protein sequence ID" value="KAG8195541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIQ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7726" checksum="2734BD9F0B813198" modified="2024-11-27" version="1">MRLETPQTPRSQRPLPTAAADVIRSLCSQQRPKSLASENPSISHLSPLPHLLFSLQKDSLKFLMMGGRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VK27</accession>
    <name>A0AAV6VK27_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase InsH N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000073">
        <property type="protein sequence ID" value="KAG8196254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VK27"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16746" checksum="276FC5A08D5B2CE8" modified="2024-11-27" version="1">MALVNSLRLKYFLSIGLEQILPDETLSLAIAHWYSGNRPGLSLEPECTKCAQTALARLRSHISLTFIDGVNTYSSCPRSCSASPVHVIDCIGASVGQLWTRKNFVKENSVCENCLRSHPRSSCTSSNCRKCNKSRNTLLHEESTEVQASIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VL73</accession>
    <name>A0AAV6VL73_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_009007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000062">
        <property type="protein sequence ID" value="KAG8196948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VL73"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="279"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8196948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="379" mass="42666" checksum="3862E1A7E47D593B" modified="2024-11-27" version="1">MPIFRDTGTSIDVVCRNRITPEMLTGENIWVQQPLDEFPICLPFSEVELKGEFGHVITKAAVVPCQLDKGRYLLGNQTAALLETMKNEDVPHQINAIETRAKKRKAEQEQAVGDIIEEVVDEEENENDEITIDEDDLFSFPPKEDNYEGLALLKVDSKTFLDQQKECPELKSLLEKVQENTGEPVGGLVKLENGILVKRKMDKTGVERPLLVVPKKYRNDLKAFCHEGTSGQLRVTKTKDIFSRHFFWPQCYKEIEDYVRSCDRCQRVGKPFDKKKAPMKIVPVIQEVFSKINVDACGPLPVTPSGKRYLLTAMCLSSKYPDAVPVEDITSVTVVDVLLAIFSRMGFPKVLQLDQGSSFTSALSTTFLEKFGHNSSGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLG6</accession>
    <name>A0AAV6VLG6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch-like protein diablo</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_004322</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KEAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000059">
        <property type="protein sequence ID" value="KAG8197053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLG6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000024">
        <property type="entry name" value="Kelch-like ECH-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF401">
        <property type="entry name" value="FI11917P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="58"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8197053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="597" mass="66932" checksum="2F23E6A6D0FB2430" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLP6</accession>
    <name>A0AAV6VLP6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000053">
        <property type="protein sequence ID" value="KAG8197564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLP6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="9454" checksum="344DA607E917D330" modified="2024-11-27" version="1">MLLEHSNYQSYYQLSPNWPIITPHYEEHGQLTKSKEAKEAATYENPKALFDVLRELELKTKLRRTSKLDVPTQGTLSTDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQH3</accession>
    <name>A0AAV6VQH3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_015112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000034">
        <property type="protein sequence ID" value="KAG8198900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQH3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15847">
        <property type="entry name" value="SNARE_syntaxin7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000059">
        <property type="entry name" value="Related to syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000006">
        <property type="entry name" value="Syntaxin 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF411">
        <property type="entry name" value="LD23667P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="182"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8198900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="277" mass="31166" checksum="938AF096ED8E9F58" modified="2024-11-27" version="1">MASSYSNGYQYSTYTSAETAGNGEFKRLSDVISTNIQKVSQNVASMQKMVNQLGTPQDCESLRAQLHQVQHYTNQLVKDTNNHLKELPLLPNPPNQSDQRQRKVLREKLNTQFSEALKNFQLQQRNAVTKEKASVMRARAHSGLSGNPFGDDPPSTGHLIDLQSPTQNQMMTSLQMEEEVNLELLREREEAVRKLEADIVDVNHIFTDLATLVHEQGEVIDSIEANVESAQIQVSEGTQQLAKARKHQAAARRKACFLVMFLVFVVVIIGLIIYFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQX3</accession>
    <name>A0AAV6VQX3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000043">
        <property type="protein sequence ID" value="KAG8198129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQX3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="190" mass="21201" checksum="53B5C069A730BAA3" modified="2024-11-27" version="1">MANCPAPLEQRIPCIPIRCRRGSSLFVSSRMRRDDGHGLVHRLNISKFRVTGTLGFRLGRGDKLESLLMGNDIKETRSVVFRTLLFLIQVAIQRPNKNTRLASPYIKNHYASPIASSHSSRPEQSASVDSMLIDPPFVFPCPPPEDRMSGAVLKGSENTLKWQHHWMGEVIKFCDTGKKAGGGKFPMGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRD3</accession>
    <name>A0AAV6VRD3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BLOC-1-related complex subunit 6 C-terminal helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000036">
        <property type="protein sequence ID" value="KAG8198725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRD3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019314">
        <property type="entry name" value="BORCS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046465">
        <property type="entry name" value="BORCS6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13440">
        <property type="entry name" value="BLOC-1 RELATED COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13440:SF7">
        <property type="entry name" value="BLOC-1 RELATED COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10157">
        <property type="entry name" value="BORCS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BLOC-1-related complex subunit 6 C-terminal helix" evidence="2">
        <location>
            <begin position="275"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8198725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="379" mass="41423" checksum="A754A7A380285713" modified="2024-11-27" version="1">MSEKEVFCASLDNTSIKNDKESIGISNPNQTNDIPKQNTDSQGSKHVEKASTSDENIALDSNSFDKPKLNSSSSKHLSSGESEEKLDDNQEYSEIDYDEDVMTGSYGEISLDRELLNCDKNTDSLSSREDLNCFPDEKGDVLVDEINDQKRPNSLVLTASATTSKDGGPYQVHQSMQTSMVKTDSADPSPSVSSEEFAVHSSSRHRTGSDTSGLSELQGTLTVDGDVVTFVAEDLAEKIKMSSPVSRWADASSFGGSQSSTPSLYKQALQPIHIIDPTVITDLEAHAKKVATCVDTMLENLSGTLQSISSLTVDCMETYENSVCKTCDAVDLNIKAVYQLMAKCEELNNSMGPLYCLSSDIKYIKMMLEQLEHIVEHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT54</accession>
    <name>A0AAV6VT54_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_000921</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT54"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="35"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="111"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8199834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="296" mass="32591" checksum="F2E640F8555CAF0F" modified="2024-11-27" version="1">MPVDHILHPLRLQTMAREWLLEDSGTFDYGGGVVGDRRCEFTIYQKTRGLLAGIPFANAVFQELSVRPMWLRKEGELLDPICEVARVSGPARNLLLAERVVLNILSRCSGVATAAGRMREMVENAGWCGRIAGSRKTTPGFRAVEKYGLHVAGIDPHRYDLSSMVMLKDNHVTIAGSIEQAVKDTRDRCGFALKIEVECRSLLEAMEACQANCDIVMLDNFDPEACKQTALTLKLQFPSVVVEASGGITENNVLQYANPWVDIISSSSIVQGYPTLDFSMKVTPTVSIAHSLDCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTI1</accession>
    <name>A0AAV6VTI1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000022">
        <property type="protein sequence ID" value="KAG8199965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTI1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="11082" checksum="3D56824140503CF6" modified="2024-11-27" version="1">MEQSNTESHTNEKEVLPLFPFFHRTLFTASQFITTRDGESEERREKKRCRGASDGNAAGTVGGIGRLAALAALPYSPRPPPWKGGMGSRDVNSLYNRIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTX9</accession>
    <name>A0AAV6VTX9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hexosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_000846</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus</location>
            <location evidence="1 9">Golgi stack membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTX9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF13">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8199753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="774" mass="88933" checksum="6447968EF212C145" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VU28</accession>
    <name>A0AAV6VU28_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000029">
        <property type="protein sequence ID" value="KAG8199224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VU28"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="146" mass="16434" checksum="EF23C48A94D9C706" modified="2024-11-27" version="1">MRSSCSNYASPLHMIPKRGTLEWRPVGDYRALNAQTVKDKYPIPCIADFTSQLHGTKIFSHVDHQIPINPADIPKTAICTPFGLFGSTRMQFGLCIASSTFQRFIDEVTRDLSGVYAFVDDILIAPDEHVQHLRAFSLNFKIMAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VU47</accession>
    <name>A0AAV6VU47_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000028">
        <property type="protein sequence ID" value="KAG8199291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VU47"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="121" mass="13698" checksum="BFD1D65BFF4E0BD3" modified="2024-11-27" version="1">MIKIADPPLIFTERNSNDNKFGASPSGVFPNSFIILLTKEQQTRKAERGVRAEADVKKKEPSNPDPTDLPLFRSPSGRTQRGVEMLMHPELVDYGMSFTSNDYSIFVLNSGRIWGCHNMYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VV09</accession>
    <name>A0AAV6VV09_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-binding glutamic acid-rich-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_001954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000020">
        <property type="protein sequence ID" value="KAG8200098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VV09"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF15">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8200098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20505" checksum="D86F8ADEA60EBF10" modified="2024-11-27" version="1">MVIKVYISGICGSHEVRKQQQRVLFILQSLPIDLQIVDITEPGREEDLTFMQEVAKEHNKKTQLPPQIFNGEDYCGDYSDFEVANDDDRIMGFLKLESEAPVTQNHQTNGVSETVAENNSENHVDEIDNTEKDNVEEAKDLGDVEERNQKDDEESNAEETAEVEENVKAASEEASEKEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VX07</accession>
    <name>A0AAV6VX07_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000017">
        <property type="protein sequence ID" value="KAG8200283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VX07"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10653" checksum="A834C661269B076F" modified="2024-11-27" version="1">MKFIDIQRTQEEAKRQSAKYPQYKTSNKRPTRNQNRNLSLILPTPFKNSTVAQKFQTKRCGIQNRRRKKRYATASSHKTTLSAQRPGERGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZ04</accession>
    <name>A0AAV6VZ04_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_002749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000009">
        <property type="protein sequence ID" value="KAG8201077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="525"/>
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        <location>
            <begin position="68"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="2">
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            <begin position="716"/>
            <end position="844"/>
        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8201077.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W099</accession>
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        <recommendedName>
            <fullName evidence="22">Multiple epidermal growth factor-like domains protein 6</fullName>
        </recommendedName>
    </protein>
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        <name evidence="20" type="ORF">JTE90_028846</name>
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        <name type="scientific">Oedothorax gibbosus</name>
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            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="20">W744_W776</strain>
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    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8201191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1282" mass="138673" checksum="751571BB5E7FAEBA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFU7</accession>
    <name>A0AAV6TFU7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
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    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005606">
        <property type="protein sequence ID" value="KAG8170356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFU7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="80210" checksum="79C27DC9FFEAA48C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGK0</accession>
    <name>A0AAV6TGK0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004656">
        <property type="protein sequence ID" value="KAG8170939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGK0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="131" mass="15308" checksum="B850E15870BC7294" modified="2024-11-27" version="1">MASIKEVSQVSKSLVAVVGFLITMAVICQGYSTFLKYYAYKIYMKTTHPAERVSFFKFYFNRHRNKTDEEQLLVEKEMLDPILKGNHEVLIECVEVALDRMCLEDDSKLEQKYASKEHEDLLKRTLYTASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIA7</accession>
    <name>A0AAV6TIA7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019473</name>
        <name evidence="2" type="ORF">JTE90_029435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004059">
        <property type="protein sequence ID" value="KAG8171382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010003980">
        <property type="protein sequence ID" value="KAG8171433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIA7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="8270" checksum="5A6B93CE807C69A3" modified="2024-11-27" version="1" fragment="single">VLSGVLVRWRKSKIYFQNVLCSLWMLQKIFEEYCWYYVSQVKSIFKMSCVAFGCYNKSSKKIAGISYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIY7</accession>
    <name>A0AAV6TIY7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003688">
        <property type="protein sequence ID" value="KAG8171682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIY7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="149" mass="16682" checksum="5875A42BAF34FB3E" modified="2024-11-27" version="1">MPANSPWASPIHMVPKKDKTWRVCGDFRRVNSVTVSDRYPIPHLHDFSHILSGKTVFSKIDLVRAYYQIPVEPADVPKTTVTTPFGSFSFVKMPFGLRNAGNTFQRFMHEVHLEGSSEGLRSLGSFLHPLSEVEGCPPHKVAAWKLPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJG5</accession>
    <name>A0AAV6TJG5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003588">
        <property type="protein sequence ID" value="KAG8171753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJG5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7971" checksum="406B9B3E281F12E5" modified="2024-11-27" version="1">MVDCEEDKKVDDVVSVNENQQSTLEHRIEAINTRVSCTLRKLFGSYKAFQLNGKDDACKEEDDGDDDDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TM39</accession>
    <name>A0AAV6TM39_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002445">
        <property type="protein sequence ID" value="KAG8172698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TM39"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10694" checksum="89DB1417FAF65802" modified="2024-11-27" version="1">MIKRNRRGHSYCDARGEILGPSQDELLRKHLPRMFPLIRTKVRGSKAIRYRPSSNHKRCQPAIRLCSSNDTPGSFRETKAFGFRGKYGCKAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TM57</accession>
    <name>A0AAV6TM57_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_028206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002295">
        <property type="protein sequence ID" value="KAG8172867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TM57"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8172867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="137" mass="15836" checksum="22032434F1EE3E64" modified="2024-11-27" version="1">MTEKIQRRKLKDFREKKSNVLVATQVLEEGMDIRQCNLVIRFDMPGDFRSYVQSKGRARAEDSLYVMLVEEGEQHTTFFKDLVDFKTIEKMLLAKCHGRSKPEEDDIAVHMSDTEIAPYMPKGPNGPRITMNAAIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TM68</accession>
    <name>A0AAV6TM68_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002292">
        <property type="protein sequence ID" value="KAG8172869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TM68"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="172" mass="19101" checksum="7D7259377BE3E9EC" modified="2024-11-27" version="1">MTHFRTPLRPPYAAPSSSWNVPKDFPDPERSVVLHRQMNPAYAFKKKQTTQPPSPLPQQTPVCPILSKPGCPDAPPINRLQGRRPRASINQSTPKTTPSSELNQSTPAGRRPGNKPQPVSRTVAPRTGPRTATLHLAPKQLPCRRHCRLTDSKTSNPRRAPSTPCSFRQLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TM98</accession>
    <name>A0AAV6TM98_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002075">
        <property type="protein sequence ID" value="KAG8173085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TM98"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="85" mass="9648" checksum="A89CD5609E75630B" modified="2024-11-27" version="1">MKNPPTRMTKQSSSHLCASILLFWRRRRTAATRRLSPKRVRRLRDPGAHRPKRPGLNRPSHARGGSPGMKSTTSSKRVLGIIYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMS8</accession>
    <name>A0AAV6TMS8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_019196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001895">
        <property type="protein sequence ID" value="KAG8173292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMS8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="235" mass="26861" checksum="9E859F08517E3AED" modified="2024-11-27" version="1">MGGVADLDKVVYKEQHFRRELTWAFVLEAGGTPKKKEDRRKTRRLTHTTDCGGASTFLSPLSMTNPVTAIYREDNSQIHISPSHEHYPSVVRDFILPHVDFFTTLVVVAGDDDYAVDDVTEIEFRFVQEHPSLFAITHCNDYHFLKFYMVKNNLVSANAPLDVLDNFLWQDYELYGIMLQERSSLVNISRDGFETRIVLTDWDDEDIDPEVHTLIGHLGQGDGHVQNPLALLPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TN86</accession>
    <name>A0AAV6TN86_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_001181</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001948">
        <property type="protein sequence ID" value="KAG8173252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TN86"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="215"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8173252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="353" mass="39105" checksum="D61146D2C1DB1C57" modified="2024-11-27" version="1" fragment="single">KVSVTFEPTGDDNPEAAGVVLRRFSFRGSISINTHSSAKKRHSSVHSHHEHVIKALTQSVASHHNPAFANGHLPAPLDTQTSKNSLSSLLSSTGELSLLREFILHIFPIDTESWPDKKLIFKLFDIIKAPVYFLLIITIPVVDYENDKNNWCRPLNIIHIFTSPAFVLFALGKYDKNINNFPLWGIILIISFVVAVIVFFTSKNSDSPAYHCFYGYVGFATSVVWVYLLATEIVSLLQTIGIVFRLSDTILGLTVLAWGNSIGDFISNLSVARQGYPRMGISACYGGPLLSIPYTVVIVKNGRPLRLKYDKLITLLYGSLTTILLTTIITMTILRFQAKEILESSSSACISPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNC0</accession>
    <name>A0AAV6TNC0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001939">
        <property type="protein sequence ID" value="KAG8173258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNC0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="13903" checksum="03719B105EC3EA6C" modified="2024-11-27" version="1">MSDRKTSKAVLVSSDEEDFVPLKRKMKSSGEVSKKGKRNLKVDLNLGEAAVPRVALPPYSIYLGSDILLEVKPFKKILPGVFEERRRRSKKSLQREHQDDTHSEASHRCCNEHLEANNLKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNP9</accession>
    <name>A0AAV6TNP9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002196">
        <property type="protein sequence ID" value="KAG8172970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNP9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="251" mass="29096" checksum="3BE9746F7374C064" modified="2024-11-27" version="1">MEKLPTLLTSPVRDMLSHPISPIPSPPYQKIGSGMSPLNYEPVSPDYLPPPESPPPPMAEQLSLLEERYPEPPPKRRHLPGESSDRADPRRQHHRQTPWRGSSSRHHRRTPWRPPYTRLASGLIEPHFHAKSRAVLCIRDTGFTLTNGFISYTMDRNALYPVLLEHVQHLRVGKLIFTDEATRLQWKMLVERGRTNFDFSQVPNYKMSEKNLEPCPLCHQSNCHRHIAVEGIRRMLNTKDVERIPHPVLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNS1</accession>
    <name>A0AAV6TNS1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001934">
        <property type="protein sequence ID" value="KAG8173261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNS1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="130" mass="14446" checksum="0D930957D2B2F489" modified="2024-11-27" version="1" fragment="single">YSSSTAKIADIQNVESKDEEMVLAPGVTIRKEKWLQVISGENVTESRLVRLDALEFWLREHKGKDVGSQSLWSLLSSGLMTQGFGAEAYFTSKFVGTMNSLFNSPNSKVPYSSKPHHRAAKTDSGHLELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNW4</accession>
    <name>A0AAV6TNW4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_024130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001725">
        <property type="protein sequence ID" value="KAG8173468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNW4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="377"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="668"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8173468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="724" mass="80702" checksum="E044BD8FBA8A7EDC" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQ64</accession>
    <name>A0AAV6TQ64_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001489">
        <property type="protein sequence ID" value="KAG8173789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQ64"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="109" mass="12005" checksum="D0EEDEBFF7BD7114" modified="2024-11-27" version="1">MATTATEIKCLFSDFQRTRIGFHMDKSMLGEKTSKPSNSSEYAKGTFVRKTFSTKQNISVRSQGGFSSNLTLPSPEKRCIARNPATMSSLPAADYISCKKNLLTRKEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQZ5</accession>
    <name>A0AAV6TQZ5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001307">
        <property type="protein sequence ID" value="KAG8174141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQZ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="203" mass="23588" checksum="6C95054637F3C591" modified="2024-11-27" version="1">MGDLMIFDELQAVADSLGEKCFVSLGAYSTVAPVSVPDKISELRLMVAQHPRVIEHINEGRGRPLKIFLTDIHSVQSNFTEFKINEEVMAVLKDIEVMYDDVRNANYIFKEWDEDRPYLSPEQERKVKSFLRHFRPAHWAIRYAISLMDVTGSPSQFDDAKKTYNYDGEEKLYRYTVEVRDLIKSLDENSLPLLDVQEETRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSA1</accession>
    <name>A0AAV6TSA1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_006174</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001258">
        <property type="protein sequence ID" value="KAG8174305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSA1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="55"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8174305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="625" mass="69060" checksum="15F28FA242F95CA0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TST4</accession>
    <name>A0AAV6TST4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_025047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001164">
        <property type="protein sequence ID" value="KAG8174704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TST4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8174704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="112" mass="13017" checksum="50AE6080BB94E721" modified="2024-11-27" version="1">MKPVSGTLSLEEDTFNKKPSRSRVHVEHAFGMLKGRFRCLLKENDVALKNMRHLVAACCILHNFCQRVQDEYLYTWEEPTDPMNCVDTTVFQGVQTRDAKDMQKLLIDWANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUP7</accession>
    <name>A0AAV6TUP7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RdRp catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000948">
        <property type="protein sequence ID" value="KAG8175827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUP7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014023">
        <property type="entry name" value="Mononeg_RNA_pol_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00946">
        <property type="entry name" value="Mononeg_RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50526">
        <property type="entry name" value="RDRP_SSRNA_NEG_NONSEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RdRp catalytic" evidence="1">
        <location>
            <begin position="75"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="203" mass="23411" checksum="18C68DDC5DEABD4D" modified="2024-11-27" version="1">MVIRLAPKEKELKINARAFGCKTFQDRTRAIIQEKNAMRYLSNFSDEQAISLSELDLLRKIYSLINLQKAYSGHRIFYINFDAKAWNNKFRNATVKPVMRETLDKVFDTDIFSKTHDHYEAARIYIPDDFYELYWDGQLGGIEGLNQDTWMITYLGQIKYAFKGVCDSFHLLAKGDDLRAAVPIPVAISSSTLPQDQPHPHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVF4</accession>
    <name>A0AAV6TVF4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_022862</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000925">
        <property type="protein sequence ID" value="KAG8176025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVF4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000014">
        <property type="entry name" value="dnaJ homolog subfamily A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000005">
        <property type="entry name" value="DnaJ homolog subfamily A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="13">
        <location>
            <begin position="139"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="10">
        <location>
            <begin position="139"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="366"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8176025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="415" mass="46389" checksum="D6B85BAD33D0FA6D" modified="2024-11-27" version="1">MAIFWGCARNSFLVETLKMVKETTYYDILGVKPNCTTDELKKSYRKLALKYHPDKNPSEGERFKQISQAYEVLSNPDKRKTYDLGGEQAIKEGGIGGGGMSSPTDIFDMFFGGGTRKRDNRSANVVHQLGVTLDELYNGAVRKLAVQKNVICDKCEGRGGKKGALEKCTKCHGSGMQTHVQQLGPGMVQRIQTVCSACSGQGEYINPKDRCKNCNGKKVVRERKLIEVHIDKGMEDGHKVTFAGEGDQEPGLEAGDIVIVLDEKEHDVFKRSGSDLILRMELTLTEALCGFHKAIKTLDNRQLVITCIPGEVVKHQSLKCVLNEGMPQYKNPFEKGKLIIQFLVDFPDQIHHGSVEELEKILPPRPEYILPDDADEVPLSDITPNQDSRNQRYRQAYEEDDDHHGGPRGVQCQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TW50</accession>
    <name>A0AAV6TW50_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidoglycan-recognition protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_011279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000898">
        <property type="protein sequence ID" value="KAG8176295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TW50"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF41">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8176295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16416" checksum="6A6110D74FF59FD3" modified="2024-11-27" version="1">MHTVSDPCRTKPQCMRNVQFLQDFHMDNRGWSDIGYSFMVGGDGRIYEGIGWTETGAHSINFNTNSIGVAFIGDYSEAEPSKKMLDATLNLIECGVKKGYLTPTREIHGHRDVTCTKSPGDKLYAIIRKWKNYKGGRIPKYDCSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWK2</accession>
    <name>A0AAV6TWK2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000948">
        <property type="protein sequence ID" value="KAG8175839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWK2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="109" mass="12987" checksum="4947257C22DE543F" modified="2024-11-27" version="1">MLQYDPNRNISYKLDFSDKLRELPYRPKPITRSISSFPALFETRPIISKDKFNDLQWLKKMLPADARHFYDNIPCEEESRRQQKAKLAVIKKQKKSDEDATLTKMPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXX8</accession>
    <name>A0AAV6TXX8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_024801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000833">
        <property type="protein sequence ID" value="KAG8176982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXX8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12876">
        <property type="entry name" value="SPRY_SOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035754">
        <property type="entry name" value="SPRY_SPSB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF5">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="19"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8176982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="478" mass="52837" checksum="191FDEA600B0730C" modified="2024-11-27" version="1">MGSIKDLVTETSIPRCKNLIETLFCKSDKTEETNGRIEWTWETPEANDFVNLLNDDKDVKFHRNFSSGTAVVRGAQPMTHDQYFWELKMISPVYGTDMMIGVGTPEASMTQVHDKFISLLGSDKQTWGLSYTGLFHHNGESKSYASRFGQGCTIGVHLDLWNGTLSFYKNKKHLGIASRGLTGKTLYAMASSTAACSGMRIVRSCSFPSSLQFLCCAKLRELIPDEKSVLSTVKMPPGLKVFLENNLGWLLDSRFTECVLYPSLSKRKLHSALKANSDDPLLGNVGSEDEEGYQRQMDGDEEGGYIWIGERPFLLQCTQRMGRLPPPRLGPYGCLRRNAINLLTPAPSESTAAIIFPRSDPRSFMNPRNILGEPIDEVQRRLSEQASSESPADTPISLGGNLLMTPTRILTGQTSSESRIVPPPPPVTIDDCLMVGLMDVTDGEEDDSLDLEKPAKRPRTYNYIVGLSDSEGEDGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYM5</accession>
    <name>A0AAV6TYM5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_018410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000885">
        <property type="protein sequence ID" value="KAG8176420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYM5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="64"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="443" mass="51125" checksum="9E73E840E58CB10D" modified="2024-11-27" version="1">MDSILRLQKLNPEKLVELCRMHLTFTLDLHDDEFSALMDNSSGKKKPKGYFSRFVKEKSIAEVMPLNEETISHIYQIIEYLGREINICKEGLFRKTGSLARQNELKTLLRIGDNIDFSAGLYTVHDCACVLKCFLAELQEPLLSEAHYSAHCQITDMCTDDMSPSQKNSVFERQLKATKLLLMLLPVDNYCLLKYLLLLLNQIDNAQEKNKMTSENLATLFAPHIICPRKMTPEMLRENFPRMVKCLTFLINNAMILFDPPKELVQDVLMYLYEANFEGQLQCVNEETPPVKTMVAFCDRGRAYAEPESGDYTNKALSELQEYIEQLPNSTRKRKLIKKFQKDNIVVKAERTKKHSRSRSVGDAIKRHILKNSDKRRNDMDFRHSAYNMELPTSKSIESIHVKSKSVDSLDLDGKESSKFSEIKKNFLRASRKKVQKLVKSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZ56</accession>
    <name>A0AAV6TZ56_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000864">
        <property type="protein sequence ID" value="KAG8176574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZ56"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="50344" checksum="36817B8A3FF4C839" modified="2024-11-27" version="1">MSVLTRRNGEVREFRPPKSPVRLFWPDENLQSLSVAVKEREKRVKVNSYASSSSSKAWDRRFWLFFVLFHLFGIETLPYIDLPKRKSKITATQRMLIIIWKSPKYIIRVILLVNLATRIFWLVVLPDTVIQLAFLFHALSLSFAYLKIYRNRRGITKTFESVIGVFEILAPGYTFKKYRYSVLLFFIYCQFLAVSSSILHNFTQGNNQTEQNTTNSTPISTNFPPLPTYLNLTLNIVEVLHNVAITGIVSLFVLYYSFTCKFLNKLFNEVLRHVKLIPKAQNYEVLLPAYEQILTSMDSLEDSSSFPTFLIVVNNTVGLFVVGYSLAFTADESYEFFFYSLLLGLQHMTFQIMIMLIGSNTVEAAKDAKVGIFSLPGKIPSKYEELKILMCRKFKRDSVLTLWNIYVLDRSLLLSSFGSLITYGILIGTLLKVQHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0P4</accession>
    <name>A0AAV6U0P4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-C2HC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000822">
        <property type="protein sequence ID" value="KAG8177069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0P4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41050" checksum="619DA15A04B8BAC9" modified="2024-11-27" version="1">MAHSIVVFSISTTRATSKVTSRRPVKRAASISSLLWPSQPFDLLDGTCRAICRPSINQEDFYSGHKRMHCLKYLDILCPDGMIVCLVGPFRGRRDDSETSLDDANPNPDNEGNFTQTNSRPARIPPLIITNPQFKWTEIRKKLLNTLGEERFSGKTSGEHFKLQMTTENGHRIASKLLENLAIDYSTYAFNAQNPLKVIIKNLPADTDVAEIHEAIKDAGFPMQNVHQLKKTVDFQKIPLPIFLAELETPPPPPAFSTENFPQSSNAPPPPPTTTWTPVGGHGHLPATSYQAPPVGAPPPPASAPPPTSNPGTRPNPTTPENHTSFDFRTLFIKLHLLWQKFKTSKDFVAKMEIGFEAITKLFNLFNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U202</accession>
    <name>A0AAV6U202_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000757">
        <property type="protein sequence ID" value="KAG8177736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U202"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="175" mass="19294" checksum="29C3DE97C8AC8220" modified="2024-11-27" version="1">MGNPKCSSIHRCTHVFLRTDKVCKPLQPPYEGPFKVLLRREKTFRIAIGRREVEVSLDRLKQAYYCAAEEPPPITSSNSSTGASATANDPTAPSDNGPDFRTPAAPSNIEQETPLGDATAPEPSQVPRTTVSRRYSPRPQTETKTTRGAADDTFPKPILKTSSGRTIRQPLRFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4B3</accession>
    <name>A0AAV6U4B3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_005463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000649">
        <property type="protein sequence ID" value="KAG8179107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4B3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158791">
        <property type="entry name" value="MgtE N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043910805" evidence="2">
        <location>
            <begin position="23"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8179107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="349" mass="35636" checksum="0E1CBDDFB6313662" modified="2024-11-27" version="1">MAATRTLGIFVCLCMLFYGSETLPDDYKKVLIQIRKLSSEQVGQFLKSFSPAELGLIVDSIPDNELKALFAGFSKKTIGSFVKGIPEDQQKALIKDFDLPSFFAKGLSGLPDDTLGGIVKGLNKAKLARDVKELPKEQVGQLIIEKIPNTELGKEIKEIPDDAILTTLQALPQNLFLNMKQKLSKINPDNSAPPIQPQEPLPSESPDADSEPDGNAFGAIVHELGLFNAVKFLVQESVKELPLLGDGTLLDYDGIVVAVVQYLLSHEGLLGGLLGGDGEGLLGGLLGGLLGGGDGKDGGGGGLLGGLLGGGDSNGGGGGLLGGVLGGGGGDGGGNGGGGGGLLGGVLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4N7</accession>
    <name>A0AAV6U4N7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000665">
        <property type="protein sequence ID" value="KAG8178818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4N7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11108" checksum="612FE1334C436B04" modified="2024-11-27" version="1">MPCSSGIACRLIYKGCNESLLKFGTIISGRNDEDPTPIVQSVCDGALPGRHRPRWCDEETSGHQQVLLIWLVRLLWVPVWVPVWYNAPSVPSISSPYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U534</accession>
    <name>A0AAV6U534_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000651">
        <property type="protein sequence ID" value="KAG8179050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U534"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="244" mass="28203" checksum="F8670E3238A4296A" modified="2024-11-27" version="1">MHRIDRQDDRVMNRCQRWMNGSKNGRLVSPQPIVVRAFSTLELDSAPLIAHFSFATLLPATMHPDPPCVVELFCHHHDADRLYDVNGDMVDYLRGMMLCVPMSRAQFAHMSPFFFNAKYPATRLHVSGHWSAAAGGGRAIFGVPLTVQGVPYRNHVMNALNGFVAPRKRTPCQVCIDVMDWSRPYRFDMIRDHVVRLRFMMPDDGLEGDDHWKRLIQLDKDTFKYLVARIMAEKDWSQTRCRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6F7</accession>
    <name>A0AAV6U6F7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_004053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000643">
        <property type="protein sequence ID" value="KAG8179225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6F7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09077">
        <property type="entry name" value="R1-I-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="184"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="588"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="921"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="951"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8179225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="960" mass="106804" checksum="A3BD8972B31EF51A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U772</accession>
    <name>A0AAV6U772_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IFT80/172/WDR35 TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_006275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000597">
        <property type="protein sequence ID" value="KAG8179912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U772"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="6">
        <location>
            <begin position="10"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8179912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="333" mass="38267" checksum="4784661D899E87D4" modified="2024-11-27" version="1">MEFKQQMELANLGKLALESMNLVIAERCYAATGDTSKARFLRETREIAQEAGAISGSNGYDHYQVRARLAIMNKDYKTAESMYREQHKIEEAIQMYLDLHKWNDAIELTKATDHPDLDRLNVTHFEWLQTTGQEEKARELKENKGEFHEAIQLYLAAGLPTRAGKVTNMPTLAKNDEQVQEIASALMKNEFYEHVGDLYEKIDNYHKALECYRLGNAFNRAVDLARTAFPQEVIHLEEEWGDHLTSIKQLEAAINHYIEAGKSVKALDAAINAKLGKKAVEIMEIIDDRQSLSKYLKPMAQHFYSVGQYEVAEHLLVERLRRNTKWLSLCMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7V2</accession>
    <name>A0AAV6U7V2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="13">PAGM</shortName>
            <ecNumber evidence="4 13">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_027886</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 13">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13 16">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 13"/>
    <dbReference type="EMBL" id="JAFNEN010000586">
        <property type="protein sequence ID" value="KAG8180107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7V2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000015">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000019">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="18">
        <location>
            <begin position="58"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="18">
        <location>
            <begin position="119"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="20">
        <location>
            <begin position="187"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="19">
        <location>
            <begin position="301"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="17">
        <location>
            <begin position="457"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="14">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="16">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="374"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="502"/>
            <end position="506"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8180107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="539" mass="59551" checksum="D40C016BA7B5B1B0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8K0</accession>
    <name>A0AAV6U8K0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_020893</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000557">
        <property type="protein sequence ID" value="KAG8180667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1186"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1270"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="656"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="871"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1012"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="871"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1025"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1101"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8180667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1294" mass="144575" checksum="B63E0C4CAFE7CE5F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8N3</accession>
    <name>A0AAV6U8N3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000576">
        <property type="protein sequence ID" value="KAG8180208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8N3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="292" mass="32991" checksum="3B5D02E779A1CAF8" modified="2024-11-27" version="1">MQFMVDSLHRCKIISFTQASNLPNSLCCDINNKDCMYGTCSRCEVKHINLNLNDIEEQQDVITYYKWIRKNEERLDSKKNLIRSSLGSSFASFTNDSEDIIHFQSDGPTTQYRNKTNLFLLTYFANKLGLKEVKWNFSEAGHGKSSADGVGGQLKTKADQFVAHGTDIPDAHTFYTVLKNSEIKVQLFQVSTKDIEAIDEHVMPGLKAITNTMKLKQVVWGSKSPNQLSLRTLSCFACEVKCKHYASKPSVWNFATIPALRPISQKPHQPIAPSANVRRTRSSCQTKSKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAE5</accession>
    <name>A0AAV6UAE5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_018748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000511">
        <property type="protein sequence ID" value="KAG8181512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAE5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16990">
        <property type="entry name" value="ENTH_Epsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000002">
        <property type="entry name" value="epsin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF115">
        <property type="entry name" value="FI19443P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8181512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="507" mass="55434" checksum="FBFDE6BAAAD56912" modified="2024-11-27" version="1">MTSMLNVQGLRRNVKNVVKNYTDAQVKVREATSNDPWGPSSTLMSEIADLTYNVVAFSEIMQMIWKRLNDHGKNWRHVYKALVLLEYLIKTGSEKVAQQCKENIFAIQTLKDFQYVEENKDQGMNVREKSRQLVSLLRDDERLKGERSRALKAKERFAQAQALSHSGSEAAGGASPDKNSAESSPDGLPSSRELENARPQTAGEEELQLQLALAMSKEEAEQEERLRRNDDLRLQMALTESKDVYKRVNSEEGDGTTDLLALCSSPINPPASKQDTDPWGMPVANVPDPWQSASPVNVIEADPWGATASPPVPSAGASWAPRMSTSASVSFEALGGRSNGELDDYDLLSKRSAMSSPDTSTNRGTPNLFDMAELKESLATSSFPARENGQNSNNVRKTPETFLGPNSNLVNLDALVSASDRELGSGNPFGLPPPPPVNNPNPFQAMRPPPPTINQLRAQMQIPPLPVGIVVPPVMPNPGMKLTGTKTVLYQELQSVKRGICTGCVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UB44</accession>
    <name>A0AAV6UB44_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000507">
        <property type="protein sequence ID" value="KAG8181567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UB44"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="101" mass="10677" checksum="C4F069940D916FEC" modified="2024-11-27" version="1">MFVHIYVSADIGLFATQVMGYLQKLPDHPDPLAVVVEGLLLPARPLAAVAVTGSGCPVGIASQDAPPLIGRVPRETVLGATRVRDGPGATLHRLEVRINEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCF8</accession>
    <name>A0AAV6UCF8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_028259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000498">
        <property type="protein sequence ID" value="KAG8181720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCF8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043383766" evidence="2">
        <location>
            <begin position="25"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8181720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="145" mass="16832" checksum="49AA46C79C485444" modified="2024-11-27" version="1">MNLHAYMALMVIHPIFLLQTVIDSLTFQADFPLTSIRQASSPYSDHQVITIPQLPRLLRSSSESGVTHGRRQDQCIVRMLKKNIRKQIIRLHWNIFIFLFCGVRFQWSMHGFLEQGEMIIGSKSDGECKWRNLQSHGFCGMVLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCG9</accession>
    <name>A0AAV6UCG9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_025683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000499">
        <property type="protein sequence ID" value="KAG8181709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCG9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051895">
        <property type="entry name" value="OTP_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46770">
        <property type="entry name" value="HOMEOBOX PROTEIN ORTHOPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46770:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN ORTHOPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="3">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="4">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8181709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20251" checksum="35979F176396C24E" modified="2024-11-27" version="1">MEFLWILQPSSEIKGKTSKASVSLQANDNVWFQNRRAKWKKRKKTTNVFRNPGALLPSHSLPPFGSMSDGFCSFGPAAPHDSPRWPQMGPPLGPASSLSRQHSAAAAAAAAMGGINQYMSVQVSSQLVPNSLPSITTSAPAVYQPPYAPAPATPPPSPACALAEGSDVWRGTSIAALRRKALEHTASMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCX4</accession>
    <name>A0AAV6UCX4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_017720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000505">
        <property type="protein sequence ID" value="KAG8181599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCX4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19336">
        <property type="entry name" value="Wnt_Wnt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF101">
        <property type="entry name" value="PROTEIN WNT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 10" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043708974" description="Protein Wnt" evidence="11">
        <location>
            <begin position="18"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8181599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="337" mass="37658" checksum="2C2BF9896933D005" modified="2024-11-27" version="1">MFLEVILEVALLHSATSVASIEKQDHCENLVGLTKRQIKICKKNLEVMESVRAGAQISLSECQWQFKTRRWNCSTVNGTRIFGKVLSDGTREAAFVHAISAAGVAHSVTRACSSGALGRCGCDRTVRGFSPDGFQWSGCSDNVAYGTAFSKSFVDARDLRAARGRSSARALMNLHNNEAGRKVIEYNMRVECKCHGVSGSCETKTCWRALPKFRNVGTILREKFDSATEVQPRTSGKRSQLVPLNHYFRYHSDTDLVYLDSSPDFCEQDSQIETPGTHGRQCNKTSRAVDGCDLLCCGRGYHTVTEKVKERCDCKFYWCCFVKCKECEIEVEVNYCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UE06</accession>
    <name>A0AAV6UE06_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000475">
        <property type="protein sequence ID" value="KAG8182219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UE06"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="117" mass="13084" checksum="87FE9C744B4E1921" modified="2024-11-27" version="1">MCGELRSPLAEQMAHICREGRRLLAGELLKFSSNSKQMHVHTNYILMSTPTILKTPQNPFTRSWPRNLKAQHPLTPNCPEYKEFKSPTPLKSYKGSLSAIAVGEELAGEIASDKTCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UE15</accession>
    <name>A0AAV6UE15_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000451">
        <property type="protein sequence ID" value="KAG8182727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UE15"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19761" checksum="DCDB7B9A559CD5FE" modified="2024-11-27" version="1">MTKEKSLLLFLLVIQGYCILSYGLEIKPFHFSDNLREGLRSVVVCAVMDGDPPFNFEWSKDGRPLTNDHKSLEIKPFHFSDNLREGLRTGAMCMVVEGDPPFNFEWSKDGRPLTKDHKGLEIKPFHFSDNLREGVRTESCAWSGDQTLPLLRQPSRRFEDWLLCMVVDGDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEP8</accession>
    <name>A0AAV6UEP8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000475">
        <property type="protein sequence ID" value="KAG8182218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEP8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="104" mass="11526" checksum="CAEEB8A7147155C9" modified="2024-11-27" version="1">MECAYQSNPILHFLSLFFLGFSGGHLFLAKLRGRYTLATYFFSLYFAVPPWPTSLARANDPTSFRQLMLTLLRGTVGKGCRVGEEIAGDFEVGVTPGINQISMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEW9</accession>
    <name>A0AAV6UEW9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocon-associated protein subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Signal sequence receptor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_017113</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAP-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000436">
        <property type="protein sequence ID" value="KAG8183027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEW9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008855">
        <property type="entry name" value="TRAP-delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731:SF1">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, DELTA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05404">
        <property type="entry name" value="TRAP-delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8183027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="161" mass="17925" checksum="223A951E4CDB6C37" modified="2024-11-27" version="1">MILGSLIYPAIGDICKDPKIDANSYTTVDGMVISDVACISEFSVDCNANKDFILIADKQGRQLPAVKSLDNRKYQISWTEDTENFYGGEHGVKVYDEETYAAVKKAYRNDEDVGNIPSAFFISLYHRGIYYGPWVSTEFVATAISVLLFYIAYSAKADLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFC8</accession>
    <name>A0AAV6UFC8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000452">
        <property type="protein sequence ID" value="KAG8182699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFC8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="9645" checksum="C9048EB793B4C621" modified="2024-11-27" version="1">MSERGRLIFISKGCARPGLVLVIRSPTDFNCTRLNICPLTNIRSTRKGIFLPAKIIKHFSGHGHSMLLSTASVSCSSTSNEGTHCPEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGW4</accession>
    <name>A0AAV6UGW4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000414">
        <property type="protein sequence ID" value="KAG8183552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGW4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043675364" evidence="1">
        <location>
            <begin position="21"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="435" mass="46316" checksum="E742AD301D4AA3F8" modified="2024-11-27" version="1">MKVLVAALVLLGCVGHFCHAFKPGQVMCSMPKCQDGCEIDPTTKPCPSCSCKDEIRNITKRSPQRPQCSMPRCNGAGCYLDFSGICPSCRCNGRRGGGFGGGGRSGLQCSPPNCRFGCFVDYSGICPRCRCGGRFKRTPQLGGIQCSPPKCDAPCYMDYSTQPCPSCKCLNNQRNNNVQCSPPNCGRGCSIDYSTQPCPSCNCGGRGGAGAGIQCSPPRCGAGCTVDYTSGPCPTCKCDSRGSNQGIQCSPPRCDRGCTIDYNAQPCPACRCNNNNQNPYGVQCSPPNCQRGCTLDYSTKPCPSCKCGGNDNYRQPGGVQCSPPRCGPGCTLDYSSQCPTCKCDSGRNFGGNQPGGVQCSPPRCPPGCRIQTRYNGPCPGCDCGRTCINTEKDISLLNKHGDSSNRMAFHDFVWSSGVLFLGGERRLQLHMKSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI86</accession>
    <name>A0AAV6UI86_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000419">
        <property type="protein sequence ID" value="KAG8183371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UI86"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF23">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="2">
        <location>
            <begin position="124"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8183371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="297" mass="33004" checksum="E398807EAAFB1F8E" modified="2024-11-27" version="1">MMNKTEVGPLRGSADRTDSGKQASTLAMHIEYKVFLAAEQSRSHLSSLKADPVQVDLVRPRRSQDAVNEPADKIVCELHFAEKEIRCSSGVSSALLQPRLNPGAVPTVFEGCPSSSEQSLCDPGYTDWKNVSQRLSEHENCTFHRDAMCSFSAKRDSRVDCTLVQEQESEFKYWRNVLRRVVEAIKFLCQHGLPIFGSDETVGSLSNGNFLGSLELISQFDPFMAEHLEKFGNVGRGKVNYLSSTIVNELIQIMGDTVLKKILEDICAAKYFGIIVDSTPDISHIDQLSVVIRSVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIR9</accession>
    <name>A0AAV6UIR9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_025396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000387">
        <property type="protein sequence ID" value="KAG8184086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIR9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8184086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="348" mass="40125" checksum="26205DB193736CF7" modified="2024-11-27" version="1">MSRHSQLFVGRLPLDSREKDIESLFKKYGSLVRCNLKSGKSTGMAYAFVDYEDKRDAEDAIKYENGRDLRGQTIVVEWARGPSSRPPMRSRTSAECYRCHRHGHWARDCPELERDRYKARRYSRSNSRSRSRRYRYSYSRSPSPARGRWGGRRRRTPSQVRSPSYNRSRRPKKRTPTPASSRSRSRSRSNDKTKEKSRRSYSKSVSRSPSPKRKHRSSRSGSKDRSRSPVSPRKARNSRSRSVSKGASPKRAKRSRSGSSKRSASPQKQARPSKELSRSRSRSVEKRMSKSRSPSTDKLPKDAENGDRKRISRSRSASSKGSRDRSRSASYDKEPARSPKGRDWSKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIY6</accession>
    <name>A0AAV6UIY6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_025148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000413">
        <property type="protein sequence ID" value="KAG8183596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIY6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056371">
        <property type="entry name" value="DHX37-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23362">
        <property type="entry name" value="DHX37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="246"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="523"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="479"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8183596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1134" mass="128639" checksum="DE996C64818D6EFF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJ74</accession>
    <name>A0AAV6UJ74_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000385">
        <property type="protein sequence ID" value="KAG8184180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJ74"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="193" mass="21056" checksum="4EF50BF36AFED7B6" modified="2024-11-27" version="1">MCCPNRGGALTRSAKRPSRDYSKTARSSAARKQQLLRGDVMCEATPGGRKDSETVRLQSCDEGKITCSSFSTGGNGSYSVSSLTAASAVHVRPPRIEGTPYIREKSMHRRQPLLTPMFHASSFSPRLRKNGCWMKTKTLSLWAPLAPVAVGWGGPTPHGRVSNPQPFESCSIRCVATTPDHLLAWIRMGKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJB6</accession>
    <name>A0AAV6UJB6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_008303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000419">
        <property type="protein sequence ID" value="KAG8183406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJB6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="5">
        <location>
            <begin position="11"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="170"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="314"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="601"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="730"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="803"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8183406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1035" mass="119821" checksum="9C3A7C6568AA5F2F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UK76</accession>
    <name>A0AAV6UK76_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000384">
        <property type="protein sequence ID" value="KAG8184203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UK76"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="142" mass="16754" checksum="EADC2E5271DEEFB5" modified="2024-11-27" version="1">MASKLLSFQEQGNEFEEIDSDKRTIKANIPLEEIHLFFNTQLDHFITPPSLYFFKRFKLSTDFLKSDPSMWEQDLSFVKGKNIVRNLRVDTTERGVELIQDYSDTIRKDEKQKQYLLQIISECRKIYPDVTKSTLEKPLPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKE6</accession>
    <name>A0AAV6UKE6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_001095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000380">
        <property type="protein sequence ID" value="KAG8184278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKE6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17082">
        <property type="entry name" value="RAWUL_PCGF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000122">
        <property type="entry name" value="polycomb group RING finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032443">
        <property type="entry name" value="RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825:SF29">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="504"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="807"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="823"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8184278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="859" mass="95308" checksum="FD4F7233BEA39739" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKS6</accession>
    <name>A0AAV6UKS6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000363">
        <property type="protein sequence ID" value="KAG8184754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKS6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="10256" checksum="DB6D859026DEE09F" modified="2024-11-27" version="1">MPRRLLKNLIIFLIGLLLMGVHHTYMNDNEKNKIFGCYLVCWLFASILDLRGWVNWSIMVNVFHVICIKMCDNKMLRQTVFYYLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UP69</accession>
    <name>A0AAV6UP69_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000315">
        <property type="protein sequence ID" value="KAG8186051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UP69"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="176" mass="19992" checksum="AC7D94BAC2156BA5" modified="2024-11-27" version="1">MADAQEDEELEILKRNPKLRIIQVSVPNSSKEFVQTLQNEIRKLKPSKKTTHGKKSVFVSKELSNCSHVFVYNNATVSSLHPVYLGPFVVKKAPKYFDIEIKGIVKRISIDRLKLCFTLHENSEQSKTDASSTATMDPPPTPCPNKSDELLPKGESYTTRKGRKVKFPKHLEHYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPC4</accession>
    <name>A0AAV6UPC4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_023312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000330">
        <property type="protein sequence ID" value="KAG8185613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPC4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF6">
        <property type="entry name" value="CALCYPHOSINE LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8185613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="292" mass="33585" checksum="B911D4DFC998ADA5" modified="2024-11-27" version="1">MLKPAKYQETLNRSFQQYWSPSPEQPLEHLNINTGRITKHKMLRAMKLPKCVAKFHPDWSDLLFIVTGVYLLWKQVTQSEMPRPVSAQTRNEQVMKERASKKLLSADDPIERLRLLCLQRGSRGILGLGRVFRRIDDNHSGDLSMEEFIKGVRDSGLDVSDEEGEALFNRFDADGSGSVKYDEFLKAVRPKMSASRHALVEKAFMKMDRSGDGQITQEDLRGVYSVQNHPDYLNGQATEKQLLNRFLRNFEENGVVDGVVTKEEFFDYYTGVSASIDEDGYFDLMMRTSWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UR76</accession>
    <name>A0AAV6UR76_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TBC1 domain family member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_020494</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000288">
        <property type="protein sequence ID" value="KAG8186816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UR76"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.680">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039842">
        <property type="entry name" value="TBC1D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043039">
        <property type="entry name" value="TBC1D7_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13530">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13530:SF3">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="11">
        <location>
            <begin position="49"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8186816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="288" mass="33545" checksum="5092D65E67DA614D" modified="2024-11-27" version="1">MTDKSRNFRSSYYDKVGFRGVEEKKSLEILINEKPMDKGKLSKFCLRFTLPSIYREYVWQVLLGVIPVNAENHNSILQQRSEHYVELENSLKVMLKIKDDTPKLIIHTLMFLLTEDVLEYDIQKQLSTSKVQSLIVLASLFIELSSSEETAFWLFKNFILHQRKLNTKYKNVSQKEIVETILKKEEDVLFEHLCTTKCFDSIPLDLWFDRVFAEVLHESSIARICDKIIGGSCKILPYILSALLIVRRHLLLPLNDADKMVELLEKNPEDVSELAVNKALELYYTANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTH5</accession>
    <name>A0AAV6UTH5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000264">
        <property type="protein sequence ID" value="KAG8187656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTH5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="102" mass="11615" checksum="31392DB63C55E523" modified="2024-11-27" version="1">MEQAPNFEGNWNYFCIPAPRARQKTSPNSSKTHNRNRNRPTGVLSAGKMTTQMPPVTIGAYLPILTENSVDKIRCEVSHINYFFENTVKNKSSKISIRLNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UV00</accession>
    <name>A0AAV6UV00_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000280">
        <property type="protein sequence ID" value="KAG8187081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UV00"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="33095" checksum="504164A2E51344CF" modified="2024-11-27" version="1">MESIEFFKTFEEVEKYVDHLKEQHTPLAIHSSTPASVYNKKLKNSEYHLGPEVKYFKITYACKHFGTFKSRGKGIRKVNSVLKCDCKFFISFKYERMLKGYRVMKKHFTHNHEIGAEYYYQYAENRRLNSVEREEALQLLESGTKPKQLRKIMQEKTSKVILIQDLHNIRKKRKHTKASFKPLTQLDKYKKVVLLSHRIADAASQLSDEDFRKNFKTLEYILECIQNKETLEIFKENDVLQNGNASNVLEESVVNGSQPMSVLQELEAVMQDVATEQDKRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVF5</accession>
    <name>A0AAV6UVF5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_020660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000276">
        <property type="protein sequence ID" value="KAG8187231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVF5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000013">
        <property type="entry name" value="Tubulin-folding cofactor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="177"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8187231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="238" mass="26728" checksum="E10E52FAD8C7543E" modified="2024-11-27" version="1">MGDESKPDLLDILVTSSINSFGTQRRFPKDLKIGELKQKLELLTGASSGSMELELLNDKQEIIAKLVGDDSILGSYPLEGAKVLHVTDTFHQAGEFEDVSKVKKFELSEEEYLKREDTLRAFKEKMKLQSGGDAKAALEEKKLKEEEELIKKIVVGNRCNVRVSGKPNRRGTVMYVGKTEFKPGFWVGVKYDEPLGKNDGSVGGKRYFECEPKYGGFVKPHDIIIGDFPEETYDLDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UW15</accession>
    <name>A0AAV6UW15_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000263">
        <property type="protein sequence ID" value="KAG8187676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UW15"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="114" mass="12902" checksum="A178F9C591A75AF8" modified="2024-11-27" version="1">MFTRVRSFCHCEKYPAVPIGLKAVLPDNLKRKKTNGVIFARLSHTNGSFRPGPHFHAYDVCLIARAAPKTRAELTPLDPFLADHLRKGSCLTKLYLHHLGDSFISLTFRLIQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYA0</accession>
    <name>A0AAV6UYA0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYA0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043720038" description="Cuticle protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8188495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="19165" checksum="66CFDFD586A19E80" modified="2024-11-27" version="1">MLSQAFLFVVILGAVVANPPLLHHEPIHHVAKPYAFGYSVKDHHGEQHREESGHGGAVKGSYGFTDARGVHRQVEYVADGAGFRAQVKTNEPGTANQNPAAVHMISDAPIHHHGFAGHHAGYLGEHHGHHGYGGLGYGVAGPYGNYGYGAGYAGSYGGYGYGGYGLGLASGLLGGLGYPRYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0N5</accession>
    <name>A0AAV6V0N5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neuroproteinsis</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000186">
        <property type="protein sequence ID" value="KAG8190335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0N5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051291">
        <property type="entry name" value="CIMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580:SF28">
        <property type="entry name" value="BOREALIN N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580">
        <property type="entry name" value="SHIPPO-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="75936" checksum="B74E8887842F5A2E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0Y0</accession>
    <name>A0AAV6V0Y0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="18">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">JTE90_022019</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="18"/>
    <dbReference type="EMBL" id="JAFNEN010000185">
        <property type="protein sequence ID" value="KAG8190375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0Y0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000008">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000013">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000025">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF9">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 18" id="KW-0697">Rotamase</keyword>
    <keyword evidence="11 19" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="21">
        <location>
            <begin position="85"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="21">
        <location>
            <begin position="202"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="19">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="19">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="452"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG8190375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="491" mass="54860" checksum="8EBCE0475E2E7CDD" modified="2024-11-27" version="1">MFTILQLQLQTYLRKSSRFKKAFLKLYITFVITLNHFFKMSDKVETEAPAYTPGPNAVDISPNQDKGVLKEIITPGSGDEFPGKGNKVSVHYTGRLTDGTKFDSSVDRDELFEFTLGQGEVIKAWDIGVATMKKGEKCVLTCHSNYAYGDKGSPPKIPAGATLVFEVELFSWKLEDLSPEEDGGIQRSIIIEGEGFATPSEGSNVEVHLVGKHDGKQFEERDVKFELSEGCEVGVVNGIETALQKFNKGEKSKIVLAPKYAFGSSGNAELGVPPNATVEYEVTLKAFEKEKESWNMSIEEKIEQSEIAKSKGTNYFKDGKFEIASKQYKKITNFLHYETGAEEEKSEKSNSILNAGYLNLAACYLKLERYDEVVQSCEKALEIDPKNAKGLFRKGQAHLALKDYEQARNCFVKVLETDSTNKAAQKNLYVCKEFIRKQLESEKKMYQNMFKKMAEQSMDAEPTSGDSNSNENGLEKTESEEKQAAETAVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1E4</accession>
    <name>A0AAV6V1E4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000207">
        <property type="protein sequence ID" value="KAG8189693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1E4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="95" mass="10693" checksum="89237B7FB786D161" modified="2024-11-27" version="1">MAPKYQNNSMANSLEIVPPTTPVQLLYNNFPAPLVSCYLTDGGIGAYKSQMALTRHILLKPDKARNSQMQFPLFTPLPMSYEDVSEVKEEQEEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V285</accession>
    <name>A0AAV6V285_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">A-kinase anchor protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_008692</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000192">
        <property type="protein sequence ID" value="KAG8190157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20815">
        <property type="entry name" value="C1_p190RhoGEF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051632">
        <property type="entry name" value="Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944">
        <property type="entry name" value="AGAP007712-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944:SF21">
        <property type="entry name" value="CYSTS, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="12">
        <location>
            <begin position="676"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="860"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="408"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="480"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="739"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1641"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1750"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1514"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="754"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1643"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1752"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1771"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1819"/>
            <end position="1837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8190157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1837" mass="206302" checksum="174BEFEF248DBB53" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4W0</accession>
    <name>A0AAV6V4W0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_026836</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000152">
        <property type="protein sequence ID" value="KAG8191805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4W0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8191805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="145" mass="16915" checksum="67C566A83CBABA1D" modified="2024-11-27" version="1">MYFHFGVDTIILFKEWTTSSTQGLIFSVIGIFILAMIYEGLKFFREFLFKKYFTSLEYSSVSVLGDDGKPVTEVHKVARNRMLSWPHILQTFLHIIQMVLSYFLMLIFMTFNVWLCLGVILGAGFGYFLFGWRKATVVDITEHCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5R6</accession>
    <name>A0AAV6V5R6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_025295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19234"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000146">
        <property type="protein sequence ID" value="KAG8192029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5R6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043596800" description="Palmitoyl-protein thioesterase 1" evidence="10">
        <location>
            <begin position="17"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8192029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="306" mass="34852" checksum="E06ECE3A7E34A5A4" modified="2024-11-27" version="1">MKVFIVLSVLIALSKSQLISENDIEYQDSPVPIVLWHGMGDSCCNPISMGSIKKFLEQSVPGVYVHSLKIGNNVLENMENSFTMNVNDQVTMACNQISSDATLKGGYNAIGFSQGGQFLRAVAQRCPHPPMKNLVSFGGQHQGVYGFPRCPAESLKVCDYVRRILNEGAYTEWVQEHLVQAQYWQDPLDEETYRAKSLFLADINNEREPRNQTYKDNLSKLENMVLVMFSQDGMVQPKESEWFGFYKPGQAKELLKLQETDLYKEDWIGMKAIDQQGKLHLLETVGDHLQIDLNWFKKNIVDKFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5Y5</accession>
    <name>A0AAV6V5Y5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_006095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5Y5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043518332" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="42"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8191349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="287" mass="32168" checksum="DDF843765BF069D6" modified="2024-11-27" version="1">MSSQRWTMVVRLLVVGCVWTTVVVAIEDYEKCGVGPVLTSRIVGGNESEPNKWPWQASLMLTHPQFGRVGHWCGAVIVARKWVLTAAHCILNPLFSLPQPVWWRVRVGDHNLQLSEGHERTVQVSEVHFHPWYHAYDKDIALLKLEKELHFDDYVRAACLPDIEDGHQGMRCVATGWGKVDFDKRGSSVLREVEIGVLPNHVCHSAYFPTYKIPIKGWHLCAGETVGGKGTCQGDSGGPLQCQVGGRYYVVGITSFGSGCAKEGYPDIYTRVSYFADWIQEIMQRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9B6</accession>
    <name>A0AAV6V9B6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_005553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000127">
        <property type="protein sequence ID" value="KAG8193204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9B6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="152" mass="16647" checksum="F0715DC352D56336" modified="2024-11-27" version="1">MVDPTSAPEPHLAPNVRGIVFSSLIVLAAVVLLIVIIVTIVYAVKGAKLKKEIAKSSNSVPLQSISSSVPNASTVPRGTDVPRQPPTVPSQDTSFYNRVRRSFRGERASTNVETHAVQQYSNESYQVPSMYPSLEVTQDMYGVDNKNFKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBE3</accession>
    <name>A0AAV6VBE3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_028126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000132">
        <property type="protein sequence ID" value="KAG8193006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBE3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="305" mass="34700" checksum="CA917CFF97BA102C" modified="2024-11-27" version="1">MCLLTLYKPRNQGIHLSTLETNNNKGSVPEVVPSDRPVDGRLTFHPTKELPLMRDWFHSCRNPSRRTLQMYVDLLNQGSVRQQERPKVAVNTLKNWWKNEKQRERKNQKSDDQTDEPSKPKRKKSSDDSQAKTDPPDENGSHTFSNSDSQDTPPKANNKFTLINHSESESDIYRVEEIHPKDISENSLAGDSVPHIPRSSPPKDNFKFTLSHTDHEVVTVPDNRLNEHIIHPILPMKDSIDSPFFHKLHPVCIDHPHGLFGFPDHHLGMPGGNKIFGDSESSGRTNLMEESNSHMSSEDDVDVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBH5</accession>
    <name>A0AAV6VBH5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000114">
        <property type="protein sequence ID" value="KAG8193837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBH5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7775" checksum="5272598C49512AA2" modified="2024-11-27" version="1">MGRRCHTPWGWRPPVANSSSLKTKERVPPQNTISQSGGRVAAVARKGMSPSPSGSLKACQVYRKLEMFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBZ2</accession>
    <name>A0AAV6VBZ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000118">
        <property type="protein sequence ID" value="KAG8193562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBZ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="116" mass="12405" checksum="7D5CE98586F53889" modified="2024-11-27" version="1">MNIDGKTFLKSVGQELLAANYDVKGHAGQKRSTSRKAQTNKSASATRKSAGTKAAARKTSKPRKSSAKKTSNSRKKSTGTKRSSTSTPRKNSANKKKPKKSSKGQAGTNPQQQMHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCM4</accession>
    <name>A0AAV6VCM4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_003047</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000109">
        <property type="protein sequence ID" value="KAG8194106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCM4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20413">
        <property type="entry name" value="Tudor_TDRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047379">
        <property type="entry name" value="Tudor_TDRD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681">
        <property type="entry name" value="SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681:SF24">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="423"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="513"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8194106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="551" mass="62757" checksum="ED30FC5590AC4043" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VD37</accession>
    <name>A0AAV6VD37_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000114">
        <property type="protein sequence ID" value="KAG8193843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VD37"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7813" checksum="9DDC29F394FC298B" modified="2024-11-27" version="1">MKLVTEPGIFGDLSKGRYEGPNPQIGAYRKGAKRGPRGQGRRVARRVTQWVEQKGALIFFGNLQVQDRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VE80</accession>
    <name>A0AAV6VE80_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_029204</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000104">
        <property type="protein sequence ID" value="KAG8194327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VE80"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF246">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 63E, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="34"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8194327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="677" mass="76253" checksum="50E9D26740EFBA21" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEQ1</accession>
    <name>A0AAV6VEQ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Splicing factor U2af 38 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_013252</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEQ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12538">
        <property type="entry name" value="RRM_U2AF35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000055">
        <property type="entry name" value="Splicing factor U2AF 35 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="44"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="189"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8194499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="28884" checksum="AF056F232365BBFE" modified="2024-11-27" version="1">MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRIHNKPTFSQTVLLQNLYHNPQNSAQSADGSHCKFLTNLTEEEVQEHFDNFFEDVFVELEDKYGEIEEMNVCDNLGDHLVGNVYVKFRKEEDAEKAVEDLNKRWFAGRPIYAELSPVTDFREACCRQYEMGECTRSGFCNFMHLRPISRELRRELYGRHRRRKSRSKSRSRSRERKRSRSRERRPRRSRSREREKGGDRDRRDREGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHD4</accession>
    <name>A0AAV6VHD4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000086">
        <property type="protein sequence ID" value="KAG8195508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHD4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="265" mass="29255" checksum="9C92DD6B7FD064B2" modified="2024-11-27" version="1">MDLTSPDHPLFGTKLTTNGQAIDSSELIIDSNNSQALKSTLPNSRPTSPMMVSNDVVSSAPSTPAPPATDICRNKLYYQAQLNDTIKARDNYLYLLNENEQLFQPEQKAMHKASIASHEAHINVLKQILAEQAIKCPIPNCKFHYPTPDLTILNTPTKRKKKQSEGSSDDEGFKSPPKKLIARQIITVNKPDTETKNQFDALADSPTDEPVTEQTQPQEKVPAVMLFRALLNLSPTTPAPPSRISGQIEIAKLRSTKSRKPSPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VI57</accession>
    <name>A0AAV6VI57_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ankyrin repeat domain-containing protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_009595</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000071">
        <property type="protein sequence ID" value="KAG8196379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VI57"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="11" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8196379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32010" checksum="5D5BC6525102477A" modified="2024-11-27" version="1">MTESDSGVDTGSESNESNSMSVGSPSRSDEDKDINDFVEKAHPAYPHLGVPFGNLQPVACSYGFSDYRQQEQVRKIKPGLQRRNVGRWKQQPIPNMKDLIGERRLRAAANSNAIDIMKNLLDNDVDPCAADGRQRSPLHFAAAAGYTEAAQLLIERGADPNQRDSVGNTPLHLAACTTHIEMITLLLKAGTDINALDYSGRSPFHVAQSKLKLLQRNTEYSSEQLKREVVHVVEMMQVYLQRSGRAVEMDLMNAFSNRLHHHQTREEFDGDVKDLLMSLSHLNLQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIZ4</accession>
    <name>A0AAV6VIZ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dorsal root ganglia homeobox protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Paired-related homeobox protein-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_014500</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with RGMB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000064">
        <property type="protein sequence ID" value="KAG8196767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIZ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000126">
        <property type="entry name" value="dorsal root ganglia homeobox protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF337">
        <property type="entry name" value="ARISTALESS RELATED HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="90"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="16">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="151"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="376"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8196767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="426" mass="46009" checksum="3C21DFC3E1EFF95E" modified="2024-11-27" version="1">MGGFVVSDVIRKPRPSEVGSEAMPLKRRSYKFKSTINKTKMFCYHCPLSVPPSSVAPRPPPLPFSVYSAVSPYSGYGYQSDLHDDNFVRRKQRRNRTTFTVQQLEELEKAFAQTHYPDVFTREDLAMKINLTEARVQVWFQNRRAKWRKAERLRKEREEKDRVPTAGDEQGGSATPADEEPADDPSLPAVSSPASSQRHLSDEEDADSSGRDDDLSPPRASAATAAAGSASGDEAAAEAAAMEGSLAVISKSSSSSESSSVLMGSNSSSDQLADFPSLLLSRSPMGSFGGDSSILKDPSGCLRPGSFLRSSLFSSLSSGGPLSSQACMESMMNTGGRFPLPPMYFPHQFGHQFAPSSLPFKAFPFCACCLPKPVTTSSAVTSSSSSPDLTSTSVTDLRRKAREHSQALLQSAMNNGSPHQQHQDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VL86</accession>
    <name>A0AAV6VL86_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VL86"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.740">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF18">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="1">
        <location>
            <begin position="15"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="156" mass="18058" checksum="E178619C9E16D0B4" modified="2024-11-27" version="1">MPLSHFDERSGIVSVDTPWGRWWQTVSEVLIEVNIPEGTPGKQCKVSISPNHIECRVLDKTIFKGDTYKTVHPEESTWTVEERKKIVILLEKAEKFENQNHWVGLLKDDYLANPLQQNEMLKKLDLEKFQMEHPGFDFSGAELSKTYDNHPVLPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMG3</accession>
    <name>A0AAV6VMG3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_013473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000056">
        <property type="protein sequence ID" value="KAG8197346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMG3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000250">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8197346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="170" mass="19449" checksum="F841AFA588FAF40D" modified="2024-11-27" version="1">MMCKCFSQFGKICRVYQILIPPNSISISKTILWYLPTKVVPVPVLLVPNPYPLQPEATHPQTHGAVATRLPDLWKEVQRPFQAQKSLCPALQIRVHIPLNVNFTNAWIASPLSKSTLHRCPMCDYRTLNKGHLQRHILGHTGEKPFKCGVCGKCFRQKAHLRVHFITHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VML4</accession>
    <name>A0AAV6VML4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000047">
        <property type="protein sequence ID" value="KAG8197917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VML4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="120" mass="13970" checksum="D0AD84A4E3A490CB" modified="2024-11-27" version="1">MDTENFSPQVHFYRCSVELTTTNKGVFTNRVSGLMSRDRRPCEQVESRKNAVVVSNFFATVTFNREEKSLKARPIILFPEMLFFGKGTLERTLRSRRSWIESRLGSRNGTEKEFCVFFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMX4</accession>
    <name>A0AAV6VMX4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_014931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000055">
        <property type="protein sequence ID" value="KAG8197450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039895">
        <property type="entry name" value="COBL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019025">
        <property type="entry name" value="Cordon-bleu_ubiquitin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21557">
        <property type="entry name" value="CORDON-BLEU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21557:SF2">
        <property type="entry name" value="CORDON-BLEU PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09469">
        <property type="entry name" value="Cobl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="3">
        <location>
            <begin position="1490"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="910"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1139"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1285"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1424"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="847"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="944"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1159"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1193"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1299"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1340"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1366"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1432"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1467"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8197450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1535" mass="168500" checksum="57E8531DD9EA34FF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMZ2</accession>
    <name>A0AAV6VMZ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000045">
        <property type="protein sequence ID" value="KAG8198037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMZ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="11064" checksum="B0DC927087B9DA72" modified="2024-11-27" version="1">MPPTKESSSEKAAAGKDIRLMGISVLLIRHVSLREIVYCQSMACGLWGGFAPIISPATEKMKSTQNVFRRLVLDTETYCLFMERDKCRLEPVVFRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VN14</accession>
    <name>A0AAV6VN14_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MAGUK p55 subfamily member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_024274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000048">
        <property type="protein sequence ID" value="KAG8197875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VN14"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06799">
        <property type="entry name" value="PDZ_MPP3-MPP4-MPP7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11862">
        <property type="entry name" value="SH3_MPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="L27" evidence="7">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="L27" evidence="7">
        <location>
            <begin position="68"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="140"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="228"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="364"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8197875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="65165" checksum="7C05F03AC6974916" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNN5</accession>
    <name>A0AAV6VNN5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Minor ampullate spidroin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_001629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNN5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1350">
        <property type="entry name" value="Spidroin domain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.60">
        <property type="entry name" value="Spidroin, repetitive domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021915">
        <property type="entry name" value="RP1-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021001">
        <property type="entry name" value="Spidroin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038542">
        <property type="entry name" value="Spidroin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043070">
        <property type="entry name" value="Spidroin_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12042">
        <property type="entry name" value="RP1-2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11260">
        <property type="entry name" value="Spidroin_MaSp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubuliform egg casing silk strands structural" evidence="2">
        <location>
            <begin position="340"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Tubuliform egg casing silk strands structural" evidence="2">
        <location>
            <begin position="654"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Spidroin C-terminal" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8197705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1078" mass="94288" checksum="E2CFD2E9462A8321" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS57</accession>
    <name>A0AAV6VS57_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000034">
        <property type="protein sequence ID" value="KAG8198923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VS57"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10481" checksum="B4758B2BD5F2CBD2" modified="2024-11-27" version="1">MNKKNDSSYSRSPLIDQPSLEIHYQSATPTFPSPEPECPPASLMSISGLSPMDFKDCKMTQSKSISSLPHDFLAGFHFFFLLQDFQCFPKPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS93</accession>
    <name>A0AAV6VS93_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Staphylococcal nuclease domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_026450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198549.1"/>
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            <begin position="197"/>
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            <begin position="93"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50304"/>
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            <dbReference type="PROSITE" id="PS50830"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
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    <sequence length="902" mass="101085" checksum="792CAB6DBF447AB8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSQ1</accession>
    <name>A0AAV6VSQ1_9ARAC</name>
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        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 1</fullName>
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        <alternativeName>
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        </alternativeName>
    </protein>
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        <name evidence="12" type="ORF">JTE90_016223</name>
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    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
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        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG8199086.1"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12881:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
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            <end position="614"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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        <location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8199086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1780" mass="191902" checksum="3E28DE8A50B448DE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSS9</accession>
    <name>A0AAV6VSS9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_007130</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000035">
        <property type="protein sequence ID" value="KAG8198828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSS9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000078">
        <property type="entry name" value="glutamate receptor ionotropic, NMDA 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="12">
        <location>
            <begin position="390"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8198828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="494" mass="56228" checksum="E67A98C9727D87C3" modified="2024-11-27" version="1">MNINSPFEVRTYIATTSSAPIINSNTFHQQYQHTMSFNYIFQQNGHNVHPYYLPLDPNPNDLALATNRFLAYNGWTRTILIRDTSTFYTKFASGLRSSIGLHVKLDDKLRDPQMFENVADVMHSDIRVILVACGNVMAKRVIEQARRANLMDGRWIWILVESAFTSDISHPKKDENQQFPAGILGIKLRKTHLDKVSVRSAVLFFASSINRRLDGGPWTQDVDNRNYTLPVSCFFGPEDKREEFAKFIHKTMLDHRLHNTTTHPPKPTFDIYNLVPRSNHPLPHHVMPHVRKVKPDQLVWKRIGNVTGGRVSLEAVLWPGRHHVGPSKRGRERYRVATAFAPPFVMPATRVENQSCLLGLPCLQVRTHSKTELSRLFADFRGQRVLEGTEYNVSCCAGISMDLMQSLAEDLHFSFDLYLVADGFFGTKRGGKWNGLTRDIASGAAHMTFTAFSLTSERSRAIDYSVPFHHSGVSCLTFTREREVPLSAFLVPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT29</accession>
    <name>A0AAV6VT29_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="11">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_000276</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="11"/>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT29"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000003">
        <property type="entry name" value="Dolichyldiphosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="12">
        <location>
            <begin position="61"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8199408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="240" mass="27830" checksum="F7178ABC26CF5374" modified="2024-11-27" version="1">MESTLDLTSKGPLQWTSLAISHVEYQNGDWLGKVLALTSLCPLALIISFATLILFRRDLHTIAFFAGIVLNEAINWICKHSIKELRPCHGREILYSEYGMPSNHAQFMWFFASYMAFFLLIRLHHGNSTHPLENAWKYIATIIVVCVATIVTYSRIYLQYHTWNQVMWGSILGIVLGSLWFLITQTTLTPLFPVIVAWPISEFLMLRDTTLIPNVMWFEYTSHRQESRTRQRKLVSMKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTH4</accession>
    <name>A0AAV6VTH4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_006186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000022">
        <property type="protein sequence ID" value="KAG8199939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTH4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04646">
        <property type="entry name" value="LbH_Dynactin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8199939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="159" mass="16891" checksum="E76C29AB2D3CA03D" modified="2024-11-27" version="1">MTSRSKVIIAPGAIVCKESELQGEITIGSRTVIHPKARIIAEAGPIVIGESNLIEEQVQILNVATGNESESPCPMIIGANNVFEVGAYIESTKIGDHNVLESKCKLGRFTELTSGCVIGAKCELTCNEIIPENSVICGSGCDRRLQIEKPPGIDIIIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUT9</accession>
    <name>A0AAV6VUT9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_000911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUT9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043563390" evidence="2">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8199823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="8125" checksum="9967CA6D59ACF51A" modified="2024-11-27" version="1">MNSNRINLILTVLLLVSSAINAHYGGGGGGGKGGGGGGLGELLVAGLVAKILSEGGEHHHCGHHHHGHHHMMMHHHGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVD9</accession>
    <name>A0AAV6VVD9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVD9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="113" mass="12947" checksum="529FD62FABD94E25" modified="2024-11-27" version="1">MGKNERSVGKRNGLVGAPTQALSIQFFQHYLWGLVLFWLPRATGCSSEDAEEHSILFPPSAREANCQKQPLLMDFTLEEKTPGPQSQWTNRMVLEDPMSFYFETLGRYLCRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWT1</accession>
    <name>A0AAV6VWT1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_000628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWT1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="79"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8200555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="261" mass="29559" checksum="3EB6C3F64D71EED6" modified="2024-11-27" version="1">MDKTGVERLLLVVPKKYRNDLKAFCHEGTSGHLGVTKTKDIFSRHFFWPQCYKEIEDYVRSCDRCQRVGKPFDKKKAPMKIFPVIQEVFSKINVDACGPLPATPSGKRYLLTAMCLSSKYPDAVPVEDITSVTVVDALMQIFSRMGFPKVLQLDQGSSFTSALSTTFLEKFGIKVVHSSVYHPQSNPIERFHRTVKRVLKVLCLESGSDWEQAIYPALFALRAVTHESTGFTPAELVHGKNLRTPLTMKNGWTWKKQKVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VY48</accession>
    <name>A0AAV6VY48_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MHD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_022350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000014">
        <property type="protein sequence ID" value="KAG8200747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VY48"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052095">
        <property type="entry name" value="UNC-13_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999:SF4">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="4">
        <location>
            <begin position="340"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8200747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="882" mass="101543" checksum="688A0ABC1DF57473" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZA8</accession>
    <name>A0AAV6VZA8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000008">
        <property type="protein sequence ID" value="KAG8201182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZA8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029731">
        <property type="entry name" value="OSGIN1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192:SF8">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192">
        <property type="entry name" value="PROTEIN CBG05349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="476" mass="53225" checksum="E6A2A88314E888B6" modified="2024-11-27" version="1">MEKEIFKDAVIIGNGPSAIALSYMLAGNWPYYNGLPHPTDFLQYRLEENKDKSLLEQDLSCLSDGLEGRSLNPISVLFDTLVRPQADLGIENPSVLSWKYDSRKAVDHIVLGKGYPGGSWQRMDSSTLTISLSSWMELPNVDIQEWDIARSRLLSTQSGLRQKRATVGTVAEYYSSYVQTQGLSPYFVNNTVVTSISPAYQEMAEESEFKNLWKIKGYTESMVCGSSEIVTSPFTYISPNIVLATGNSDEPNRLHVEGEDLPFVLYSLTNFEFLLHKKIIKPDSGQLLIVGAGLSAADAVIAARFYGIPIVHVFRRSVYDPDLIFNKLPQDIYPEYHKVHRMMKDSSRVNYEGYKAFPCSKVHTIKPDGTVIIRSCENENAVLITKVSYVLVLIGRHPDLSFLPSNEFTKLCINPEKPIDCKKNPINIKLHNHETVCYPGLFAVGPIVGDNFVRFVQGGCLAVANHITNNVKPNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W3D5</accession>
    <name>A0AAV6W3D5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W3D5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="139" mass="15663" checksum="F19FC0FE07EF90E9" modified="2024-11-27" version="1">MGIRIIGAAGSERDCQRMKMQVSGLICIFLVVFVQEASGNFNLFISKPEFLRLLGPFNYSHFETLRPLRTNILSTAFRISRHVNLRSFHSQGSNSIDALLIPAISSELMERFHYSVPLHCCSNGKVSPRIVDAPFRSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TE55</accession>
    <name>A0AAV6TE55_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006197">
        <property type="protein sequence ID" value="KAG8156205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TE55"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8156205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="142" mass="16380" checksum="05B9B35CBE6A79BF" modified="2024-11-27" version="1" fragment="single">LEKPTALEKITSLRIGNPVGTHALKSRETQSESRTHSGETEIRENPQLNRETQSGETIEKPTALEKRDPRNPQLWRNEIRETHSSGETRSEKPTALEKRDPRNPQLWRNPQLWRNEIRETHSSGETHSSGEMRSEKPTALEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TE79</accession>
    <name>A0AAV6TE79_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006141">
        <property type="protein sequence ID" value="KAG8156244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TE79"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8156244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="9525" checksum="C795D47D9938BC28" modified="2024-11-27" version="1">MFPLASSCPGHSFTIFRVPTCALKLRHFHKWNAAGHPVRPALEGTGIPECGRPPPACTFISPPGVFRPIDIAHMLDSWFRVSKTGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEX5</accession>
    <name>A0AAV6TEX5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005603">
        <property type="protein sequence ID" value="KAG8170368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEX5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="538" mass="60258" checksum="C00B5E412329F4A3" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFK1</accession>
    <name>A0AAV6TFK1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005809">
        <property type="protein sequence ID" value="KAG8160599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFK1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8160599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="118" mass="12637" checksum="3A65ABA4A20D3F63" modified="2024-11-27" version="1">MTHVKRGTWNPSPASVLKVPLEYLQTTPKICTGGGPRGLTPALKKHAPAKPPYHCGVNLHEGSSASGPGIGQRGRIHFGLVVRSVSFYTSLANSLPMATSDCLEKPNTFRARAFAWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGI7</accession>
    <name>A0AAV6TGI7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005151">
        <property type="protein sequence ID" value="KAG8170600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGI7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10449" checksum="B1DB89BFDA50130A" modified="2024-11-27" version="1" fragment="single">YGNAFLWKTSAQERNPECVPDKTDRYRTKGGFPILETSWASIMNRPATPGNQRSSRTNPRGTNPPFSQKFTPRPVRVHLALMGYERRRPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THI7</accession>
    <name>A0AAV6THI7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_025667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004573">
        <property type="protein sequence ID" value="KAG8171003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THI7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8171003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="783" mass="89390" checksum="1E7A62954C0B69FA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJ63</accession>
    <name>A0AAV6TJ63_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003637">
        <property type="protein sequence ID" value="KAG8171718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJ63"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12717" checksum="EA88D14CD8E54A5E" modified="2024-11-27" version="1" fragment="single">INWQAKIDASYYLTQRQTADQEDDPSMKTATVQQRGTLQVPVQVQVPGSLLRWTFMTKEYNIKFGLFLKEKSGKLKELVAVESVDCQVIPEENEFLCEKAGTCEYWNFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJL3</accession>
    <name>A0AAV6TJL3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003646">
        <property type="protein sequence ID" value="KAG8171716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJL3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10677" checksum="BE355E34E015516E" modified="2024-11-27" version="1" fragment="single">RLIQILRKYGKLEDDYNKWKVLSAESGIQVESPEEQWIRTSKYEYDESEEVEDDYYDNAGDYEVIGGINFSPSPYSENIDERPLWGTGETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJU9</accession>
    <name>A0AAV6TJU9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003321">
        <property type="protein sequence ID" value="KAG8171973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJU9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="120" mass="13358" checksum="A71F37DC3DAD7F65" modified="2024-11-27" version="1">MPRYLEGEVGGSMTLRTVLMSLQILLATPEPDDPQDAVVAKQCIENPEMFELTAKHWTEVYAGAPKTPSDFDAKIKKIGEHGRGREKKLAMPCLCCSWNLKEAKKITVWLGNHALTDTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLZ1</accession>
    <name>A0AAV6TLZ1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002434">
        <property type="protein sequence ID" value="KAG8172718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLZ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="285" mass="33053" checksum="1C6D6A0999A234D9" modified="2024-11-27" version="1">MLNRVFGGYYNCIQSDNLKPNSNGSNPTPDLALTLFNCRIVTTEELEGKLNENRVKQITGNSSVVFRNMYEISQSGIPTAKFFTTTNNVPVRLAQYKKEEKVIDQSYMGCFLVLSYHLKKYMNVKDGLLYCRELPPSVVEYTRLYLLNTDVYNQFKTYIDIQRSKYCMTTMTDLRSAVRQFLKNTKNNTTPETDIILKFEEEFSENRRSDIQLGGIQYESVFDQGESRLLVVENELLEPVETTMNGKRTILSDGCTRKKRKQTSDTIVYYDNVVIRNLRKTVQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TN35</accession>
    <name>A0AAV6TN35_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002434">
        <property type="protein sequence ID" value="KAG8172730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TN35"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22615" checksum="6769AD2592FE8424" modified="2024-11-27" version="1">MTRASTAEKTLESLYYSHRTKLVKCSRCDMQVLLPLLDTHMKLRHRVNPRLRCIFCNGTFRGIPFQTHHRITCLLEFIKIKDKQIRDSISKLEGQLLPTRPEDTTLEQQLCSLDDFIHENDWLLDTEELNRWLQECENDEVLPQQEVMPQQEQASVDNVQSLFPMTFAAGPNELVFTIQPDGTMTIHVRASADST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TN52</accession>
    <name>A0AAV6TN52_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002173">
        <property type="protein sequence ID" value="KAG8172991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TN52"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="111" mass="12148" checksum="58909165D613E649" modified="2024-11-27" version="1">MTPIYPEETSEGTSYWEGFDYLTPPRPSTIDCTFEPPRDLPRFFPWPGSCPGISFTIFGAPTVRSNSATSTRGTRRVSGAPAREGRGIPKCGDLRRPVLSFPPAGLFSSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNY5</accession>
    <name>A0AAV6TNY5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Smoothelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001877">
        <property type="protein sequence ID" value="KAG8173324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNY5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8692" checksum="B19C6076F287DD20" modified="2024-11-27" version="1" fragment="single">MSLADELLADLEEAGETEDALLQLDAPLQEVEDVPMETVEDAFRTIRAIAKLRDSEQLKRVMEEIARRRHQERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQ65</accession>
    <name>A0AAV6TQ65_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001312">
        <property type="protein sequence ID" value="KAG8174135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQ65"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="7892" checksum="E1C34EAA312F1995" modified="2024-11-27" version="1">MGLAPTLGNSPGEGDLLQSPSPARSLLNATFPHALASGGFGAGLLPVHSSLLRESLFVSFPPLIYMLKFSGLSRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSG2</accession>
    <name>A0AAV6TSG2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001180">
        <property type="protein sequence ID" value="KAG8174614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSG2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="171" mass="19790" checksum="4593AA2F6FC898C6" modified="2024-11-27" version="1">MSIIKVPTPGPYHDVEYVLKIHFKQDVPLLIHVVSLKYCERYYPEFVITTTDQKHNFPLQENGQRFEVPNHSSRVPVSHLPTFFATGWCHAALGRSRLGVNCPATLDYVRLILGLENVVLMDVPYTPHLSSKLQLSRLEWEVAKDREMQELQAKIARQKFFTGSVETDRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTE8</accession>
    <name>A0AAV6TTE8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_015395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001040">
        <property type="protein sequence ID" value="KAG8175275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTE8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8175275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="166" mass="18367" checksum="80510FBDD4BCA3F7" modified="2024-11-27" version="1">MSLPKEYDGVKTTLENQPLGIAGLNLQLVRARLMDAEALLEDSRRDNPPRQARCLGDTAAFSATPRKNPTCNICRRKGHIARFCRSNRGACYSCGQRGHLARDCGRTRTREHEAASTAVTFVAGQIAHKDWIVDSGATHHMCSEKTWFTNLRPHVGTISCASKMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTU0</accession>
    <name>A0AAV6TTU0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001023">
        <property type="protein sequence ID" value="KAG8175357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTU0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="234" mass="26243" checksum="277AB0B58588C6C3" modified="2024-11-27" version="1">MMKLAKGFVILVAVTILLTIIALGLTNTTRNIFKSPAKSDISEAENTSTPWVQKKFVSTIQNFNNSVFENLETSLQVQNIWHVTSDSETTRRVYFKIATKFLTDLGHPRPQALANIVSKAGSLHHPLTMPVFFEVAAINLAEVFLAHNKDIDSDDARKYVDFLSSELDMANLSDYESIVQAQYNAYAKPEEAYFSVFPSNFLQTLAILKPWILPVGESRALGHPSPQSSQQRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTX5</accession>
    <name>A0AAV6TTX5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SF3 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_022646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001048">
        <property type="protein sequence ID" value="KAG8175223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTX5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045455">
        <property type="entry name" value="NrS-1_pol-like_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051620">
        <property type="entry name" value="ORF904-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35372">
        <property type="entry name" value="ATP BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35372:SF2">
        <property type="entry name" value="SF3 HELICASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19263">
        <property type="entry name" value="DUF5906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="5">
        <location>
            <begin position="695"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="999"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8175223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1052" mass="122560" checksum="2697463CC4B9360A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUQ5</accession>
    <name>A0AAV6TUQ5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_019714</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001021">
        <property type="protein sequence ID" value="KAG8175368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUQ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16510">
        <property type="entry name" value="RING-HC_IAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="110"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="330"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8175368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="528" mass="59018" checksum="442010D3C07C3958" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUR0</accession>
    <name>A0AAV6TUR0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000948">
        <property type="protein sequence ID" value="KAG8175842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUR0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="217" mass="23191" checksum="7459BDC0CFB686DB" modified="2024-11-27" version="1">MAVETDETTSDRINDLGCQFLLAKDYPTAREILLSLRVFDPSCMLLRKAIGMAMDTFDRDWISKLQDPPKLTPIRISTKGKSTPKARAKATGGAAADPKANLVATTSNARKTSRAAFLDKGRSSPQMAALSISDHIQVRAPPSTRGATPPLVNLPSTSFQTSSNPYTPNPVAQESGPELNDDESEIGILSPTPTNLYSPPPTPFVPLCLVPNGTQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUY6</accession>
    <name>A0AAV6TUY6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dual serine/threonine and tyrosine protein kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Dusty protein kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Receptor-interacting serine/threonine-protein kinase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_019129</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010001005">
        <property type="protein sequence ID" value="KAG8175431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUY6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044344">
        <property type="term" value="P:cellular response to fibroblast growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045743">
        <property type="term" value="P:positive regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051302">
        <property type="entry name" value="Dual_SerThr-Tyr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46392">
        <property type="entry name" value="DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46392:SF1">
        <property type="entry name" value="DUAL SERINE_THREONINE AND TYROSINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="685"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="256"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="714"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8175431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="910" mass="102974" checksum="EAB92D2C05B5634E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TV81</accession>
    <name>A0AAV6TV81_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase ULK3</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Unc-51-like kinase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_016685</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000988">
        <property type="protein sequence ID" value="KAG8175536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TV81"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14121">
        <property type="entry name" value="STKc_ULK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF65">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ULK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="10"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="345"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="483"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8175536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="514" mass="58393" checksum="99322450917A4130" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVP3</accession>
    <name>A0AAV6TVP3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000923">
        <property type="protein sequence ID" value="KAG8176035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVP3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7894" checksum="BB3E49968A4933D9" modified="2024-11-27" version="1">MATEAMVLSRRHNVYKIVRCITFGSIDKCNNSVWHSLVKHNIYICSIDKGINSVWHSLVKSIYMKQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWG5</accession>
    <name>A0AAV6TWG5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_011093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000949">
        <property type="protein sequence ID" value="KAG8175790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWG5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8175790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="35052" checksum="7B18DBEA3CA912A3" modified="2024-11-27" version="1">MKTKGAYHTHYPRSHSEVTLGSLREPPAKESWKVAEGEGFYSAYILRVEDSLDVLIDSLNKKRPSMPLTQYEDEFLSSTTEDEVGVLKSQKDNKKQEVAEIKKQELSTKRLRAFPNANEFENDSDSDDPEVIPSTKYEQLKNAYDFLEKEKERVEEKLKSVEKKFSDCQKQMDEFKMENAEVVHLRSLNRQLQEKLLAIPDTQGGCCHAVINQPDIQSVSETTEIELGAGIMVDRKVYEDIMNLDHVRKFTKSLAVVIWGSQMREYLTKRGKSDEIEEELKKRNKYISDKIQCICKNISLNKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYV8</accession>
    <name>A0AAV6TYV8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_008324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000844">
        <property type="protein sequence ID" value="KAG8176884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYV8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="50"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="185"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8176884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="464" mass="53086" checksum="A89F221BEA14C40F" modified="2024-11-27" version="1">MSFVPFYPEQYPIQHRLFRPRNMIQMLVSERRLIQYPVLMLIYSETLARCLFQFDSKLGKEGNFSSPFYPNNYRENTECIYNFIGHDFETLKLTFYFFELEPPYFKGCLTDYVDISTITASNVKELVGRYCGNKIDTPLLSMHPKAEIIFRSNHIVHHKGFYGAYEFKDEKSIPPPSSSLDVEGCGGTEEGVGGVITSPGYPHSFPKDVECVWLIRVESHKHIYVRILELQLYGSIANCGDAELSIYDGYSSFTFNPEIMKKYCGDLKYYKNVEERTQMSKRNRLLIRFKTKVTSEQKGNTNKVIGFKLVWTAVGFKFPGKCEQHVCRTSHYCLNTESTICDVMPHYCIDKSLVCDGLPNCSEDDDSDEEKCHLPLVAGCGGVILLCMIGACTVFYIYRGKKQRQEREALAMQLRQLEHSPVSIARAPAYYAASDCSIHGHLAELSDDSFESNYKAYPPYPTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZ26</accession>
    <name>A0AAV6TZ26_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_010229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000836">
        <property type="protein sequence ID" value="KAG8176959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZ26"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8176959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8495" checksum="B33140084BFF9504" modified="2024-11-27" version="1">MQGYAHASASFAAYESAMSNKEPSNESHPRTLYVGNLDPSVTEELILALFGQIGPVKGCKIIQEEIVLNRKSRFCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZJ6</accession>
    <name>A0AAV6TZJ6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_018710</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000840">
        <property type="protein sequence ID" value="KAG8176927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZJ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8176927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60840" checksum="DD55402208FC2512" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1G1</accession>
    <name>A0AAV6U1G1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000762">
        <property type="protein sequence ID" value="KAG8177677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1G1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140293">
        <property type="term" value="F:ADP-ribosylglutamate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140291">
        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042278">
        <property type="term" value="P:purine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001664">
        <property type="entry name" value="PRK00431.1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="55"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="232" mass="25838" checksum="3DAED2C438F2C1A5" modified="2024-11-27" version="1">MSKEADMSFTEEKEKYLNMSIEDKRSQYNCKSKYVPLKKIPTWKEQSAKHAFAESAAYPKIEAFNEKVSIFVGDITHLEIDAIVNAANKTLLGGGGVDGAIHRAAGKSLLAECITLNGCETGEAKITGGYKLPAKYVIHTVGPIGEQTELLQNCYRNSLTVAQENGVRTIAFPCISTGVYRYPNKNAAHVALTEVRTFLEKNASSFDRVIFCLFLEEDVYIYENLIKEYFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2D5</accession>
    <name>A0AAV6U2D5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000757">
        <property type="protein sequence ID" value="KAG8177725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2D5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="193" mass="19808" checksum="72CDAF2BCF1A8EAE" modified="2024-11-27" version="1">MASAALMDIAVGTVGSVAITNAVPLDHSVVVTNAARLCLSAVLINAVCQDRSAVVTNVVWLGRSAVVTNAVRLGLSVVEAAVVRLGLNVAVENAVRLGLSVARTNAVQLVLRVVVTTAVGLGLSVVVTNAVTPGHIVVVTNAVRLALLVVVTNVVRMETIVVITNVVSLNIVAVVANVVRKFRDVGINTEGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U315</accession>
    <name>A0AAV6U315_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_010880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000729">
        <property type="protein sequence ID" value="KAG8177984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U315"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF178">
        <property type="entry name" value="LIPASE MEMBER H-A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="67"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8177984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="379" mass="42342" checksum="2EFB0943699239BB" modified="2024-11-27" version="1">MKKIKLFELFVVGGVILTQVKGQGILGLIGSLVGTITDDVYSLGSVVSSLCLSPPFEADGCEGTDEGTTEAFLFTRRNSRSPEFLHLCDWSLPNNTNFDPRDRTEIFVHGWLDGVCRSEWMREMKEELLKRGSFNVILIDWTWGNGLEYNTGAKNVYVVRKHLATLIQNIMRKSGVGAENFHLVGHSFGGQIVGLAGKIVPNLRRITALDPALAPFRNRPAFQRLDRSDAVLVDVIHTNGGSRPGETLGDIQPLGDADFYPNGGREQESCKTNIIPSLLKLDVPYAAFLLLPEFCSHLQSIQYYKASINPTECLFIGVQCPDYASFESGLCNSCGRNNARCAVMGMDYEYEPHPAPRKRRPRKYYLDTTLNYPYCKRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U420</accession>
    <name>A0AAV6U420_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_016514</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000664">
        <property type="protein sequence ID" value="KAG8178844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22827">
        <property type="entry name" value="Gal_Rha_Lectin_SUL-I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.740:FF:000001">
        <property type="entry name" value="Adhesion G protein-coupled receptor L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044023353" evidence="9">
        <location>
            <begin position="21"/>
            <end position="3468"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="11">
        <location>
            <begin position="67"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="11">
        <location>
            <begin position="139"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="11">
        <location>
            <begin position="215"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="11">
        <location>
            <begin position="291"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="11">
        <location>
            <begin position="357"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="11">
        <location>
            <begin position="434"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="11">
        <location>
            <begin position="503"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="11">
        <location>
            <begin position="579"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="11">
        <location>
            <begin position="657"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="11">
        <location>
            <begin position="733"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="10">
        <location>
            <begin position="889"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="11">
        <location>
            <begin position="1047"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="11">
        <location>
            <begin position="1142"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="11">
        <location>
            <begin position="1215"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="11">
        <location>
            <begin position="2145"/>
            <end position="2199"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="11">
        <location>
            <begin position="2219"/>
            <end position="2274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="786"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1107"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1273"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1768"/>
            <end position="2143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2275"/>
            <end position="3399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="793"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="809"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1117"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1280"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1330"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1354"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1368"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1435"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1472"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1548"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1562"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1595"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1620"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1648"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1715"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1730"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1784"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1846"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1888"/>
            <end position="1922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1923"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1969"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1995"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="2008"/>
            <end position="2054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2055"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="2068"/>
            <end position="2114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2133"/>
            <end position="2143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2300"/>
            <end position="2320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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        </source>
    </evidence>
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        <source>
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    <sequence length="3468" mass="372448" checksum="E03F1BF8D10D249A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4D5</accession>
    <name>A0AAV6U4D5_9ARAC</name>
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        <name type="scientific">Oedothorax gibbosus</name>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
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        <reaction evidence="7">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
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            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
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            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
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    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="3" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAV6U4X0_9ARAC</name>
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        </submittedName>
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        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
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            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
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            <taxon>Oedothorax</taxon>
        </lineage>
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000677">
        <property type="protein sequence ID" value="KAG8178646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="491"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8178646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1346" mass="152857" checksum="E2B58F6EDC883A36" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5U1</accession>
    <name>A0AAV6U5U1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000641">
        <property type="protein sequence ID" value="KAG8179253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5U1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="298" mass="33690" checksum="2E0BA08862F5B6D5" modified="2024-11-27" version="1">MCNKTLKVHQNSYSHLLYLFRHLAEDLKRNHNLNENDVQTAIDVMNINFRRVSKGQLPSEINFNDMNYCVGYLHRFALCHATMVQKAIVFHVLRSPPLELMVKLSPNQGLNLVGIGSGPANDVIGFLSAFKDQCTKLRSLDITVVDKMPGWNQAFTEAVRILRSDKSSGVLSTLFKSGGPDVTTSYLAGDLEMENLSQGLQTKLRSADVILLIKVLSHVPDHKKLLLLRNIETNMSPGAVLIYMDSPFPSSKFADLTSLKSVYEAERKKYKFRFRVYNFGHINLTQCHASTRIFVKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U655</accession>
    <name>A0AAV6U655_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000609">
        <property type="protein sequence ID" value="KAG8179655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U655"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="8939" checksum="6CBDDCCF9DB3AA42" modified="2024-11-27" version="1">MSRKIVTATVRLNTAHKEHARHLRNGRRPVVFFLCVHLSSQQVIIMCLQGRFVDRRVGTGNGVRASPGVPSLCASSHEGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8S2</accession>
    <name>A0AAV6U8S2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MRG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_012885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000589">
        <property type="protein sequence ID" value="KAG8180041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18983">
        <property type="entry name" value="CBD_MSL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF48">
        <property type="entry name" value="MORTALITY FACTOR 4 LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MSL3 chromodomain-like" evidence="8">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="MRG" evidence="7">
        <location>
            <begin position="1097"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="488"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="583"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="635"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="681"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="737"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="884"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="746"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="884"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="907"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1002"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8180041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1301" mass="150750" checksum="2BC2B1CDB1A5E1F3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U997</accession>
    <name>A0AAV6U997_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000575">
        <property type="protein sequence ID" value="KAG8180219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U997"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="305" mass="34913" checksum="DA8CE0236D246E99" modified="2024-11-27" version="1">MAHLDDQSGRPAQQRFLDLSTLKPQTREEVQNALYKIPEMRLRPEKLPEDENPLLPDSWRRSWSYPYMNPVPPSMVHVKIKQLSKVDIDWKMLTLDRPETALEVHIFSRIVYLNKVTRKCIANEKDRKEKAQSVRLQRLGAKYGKVAKDGDSGAKIEDLTYECFSRHFGMSDRGQAMEEIPKPATADATKPPPVTTADDPNDDATAEEENIADNSTKRKTKVRKKKLTKKKKKSKKNKLRKRKSTRTGSPTKSSPVKSKVRKVKLKKSSNSVKSNKHKLGSSGKTLVQMLKVSEKAERRQRKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9C3</accession>
    <name>A0AAV6U9C3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Calx-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">JTE90_011164</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000572">
        <property type="protein sequence ID" value="KAG8180249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9C3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000003">
        <property type="entry name" value="sodium/calcium exchanger 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032452">
        <property type="entry name" value="Na_Ca_Ex_C-exten"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00845">
        <property type="entry name" value="caca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF65">
        <property type="entry name" value="NA_CA-EXCHANGE PROTEIN, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16494">
        <property type="entry name" value="Na_Ca_ex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01259">
        <property type="entry name" value="NACAEXCHNGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="812"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="853"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="22">
        <location>
            <begin position="314"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="22">
        <location>
            <begin position="443"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG8180249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="878" mass="99261" checksum="B881434E9C5EA72D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9D0</accession>
    <name>A0AAV6U9D0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BolA-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_006252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000555">
        <property type="protein sequence ID" value="KAG8180694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9D0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8180694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11929" checksum="576F11CF380CFBCC" modified="2024-11-27" version="1">MPQYNQDYIQKKLQEELETTHLDVQDLSDGCGAKFHALIVTPKFEGVALLQRHRMVNEILKTELESIHAFNYKTLTPEQWEKQNASSASKKDMKCEGLCKTNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAV6</accession>
    <name>A0AAV6UAV6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000522">
        <property type="protein sequence ID" value="KAG8181294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAV6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="141" mass="15400" checksum="6E192BA40D3C3DFC" modified="2024-11-27" version="1">MLQWGVIPSVDVSPSYNPGMRKDADGKWNFCPPLMKKKQHVDSKPPSPNTHPGNPKPPPKPNTQTTRTAESEPPVPAESCSVREQTSRPVPFARGIHPTLRTGKKKKSISCAPLLCVFGGDVAQRLFRGQRIGLPAAHGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBK7</accession>
    <name>A0AAV6UBK7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000559">
        <property type="protein sequence ID" value="KAG8180631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBK7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9658" checksum="52D88643126C1773" modified="2024-11-27" version="1">MKSFILADVDFPFQSLLPMYRMKVAVGGHCESQESDSEIGDHALGRDLPDPLVVQSEDGHAGEMATFHPGVIPDRWFGLMVEDLQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBW7</accession>
    <name>A0AAV6UBW7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="2">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_017510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glutathione = L-cysteinylglycine + 5-oxo-L-proline</text>
            <dbReference type="Rhea" id="RHEA:47724"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="4.3.2.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000521">
        <property type="protein sequence ID" value="KAG8181343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBW7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF26">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8181343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="233" mass="26183" checksum="DD6F7FAB0C13EEBF" modified="2024-11-27" version="1">MSMWVFGYGSLIWNPGFEYLDSKVGYIKGYVRRFWQGNDFHRGNPEKLGRVATLVEEEQGLTWGRAFLLGPSASSSLSYLDSRESKLGGYCTTVVTFHPRDQHIDPLPALIYIALPSNRLYVGPAPLPKVATDIAEAAGHCGHNAEYLIRLVDFMKEQVPGVWDEHLYHLDHLVRARLEERNMKVEEVMGEEKPLAIAGLSSESSDDEVHPSSSCPSDYASRVSKRKVRCLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UC51</accession>
    <name>A0AAV6UC51_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CXXC-type zinc finger protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_023008</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000546">
        <property type="protein sequence ID" value="KAG8180856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UC51"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022056">
        <property type="entry name" value="CpG-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12269">
        <property type="entry name" value="CpG_bind_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8180856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="459" mass="52692" checksum="F907EB727EC48E2A" modified="2024-11-27" version="1">MASNSGYNKNSFTNLSTSTEICYCVCRSSHIDTFMICCDFCEEWFHGECIGVNAHDAEAIEKYFCERCRTSNSNLQITFKRKMATKRKKMSKLSTNSKTRIKHTPKKKSKYENGKIETVSCASENLDSAILEKTQPPVSDIRTVNDEDLAIIFESDTTKRKAKTIANKNIMEHTEVSTIITKHKDPPVLKQCDGPGCTKVARTRSKYCSDACGIKLGRNRILEILPQRLEQRKAVPCAADEFSKRKLAAIRRRQGQLRSSIDQMDVKIVQLLQLVEKAKSPDDKDIVIEDDPLEDENATSLHCKLCGAEVQTRLLVRHMEHCYKKQEKRLMLSGTTKADDLEWNIFCNHKMGKQGFCKQLKATCPFHHRNRPNTDEELCGYPVVMNLTECSGKFCGRLRKNCPKHPKNWEDNFRADMDMQKWKFLWSLNLLEKEEGAIRRDMAKRGNLMALLLHQTIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UET1</accession>
    <name>A0AAV6UET1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000452">
        <property type="protein sequence ID" value="KAG8182702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UET1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="137" mass="15115" checksum="814948EC6638B089" modified="2024-11-27" version="1">MDVGFSSNTVVWFRGVTCGDMGHKSHVTSGPMDLTTCSYLDLRLTLFAITLDNNYPHLFGTSERIILTKPQSKKQKSNKTLPKAQEAPYNESTHHPQLTKTTAGRTSQRPANEKTPNSNNSRCPASTNKVRDPVPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFJ2</accession>
    <name>A0AAV6UFJ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_013906</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000469">
        <property type="protein sequence ID" value="KAG8182300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFJ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="15"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="116"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="216"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8182300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="414" mass="46693" checksum="5F001143DD0ED7A5" modified="2024-11-27" version="1">MKLLLISGWVVSADPSFVEVIPNVTVAIGRDAVLQCTVEEIENYKVAWIKMDTQTLLTIHKHVITRDKRIRVTNNNLQWNLHISKVDEKDKGFYMCQINTEPMVSQLGHLDVMVPPAIIESSTSSDTVIEERSKVSLRCEASGYPEPIITWRREDGKDINLGSYGGRKYSAPRVEGEYLNISQVSREDMGAYLCIAANGVLPSVSKRILLQVNFRPKIRVPNQLVGAAAGSDVILECRLEASPSPLTSWIRSDGIMLLNNRKYDITEDKEGYKIYMKIKIFSLKESDFGSYKCVAKNTLGEKEGFIRLYEIPPPTSNPKVTQHYEVYLPRLREHLQNNGSSSQRKNPPSSNTLMDESQEFLSDKKLRSSSESDSEDETMPSRPFQGRQENGGFVTSGANFLLVSLLIILHQLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFK2</accession>
    <name>A0AAV6UFK2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000462">
        <property type="protein sequence ID" value="KAG8182441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFK2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="199" mass="22486" checksum="DF7F449F48C8BDC5" modified="2024-11-27" version="1">MNVSHPNKGKFSRNPDSKPLTTSNSESLTFLSAFVGWLSGCNYHVSLEQVLESERKLRIKSVLHLHSKKYGNIPMKVFVNELCMREAEEVDVAPFMDIVEFMDLNVSTSDTEILTYIAGYCVHKLCLTCDTCKFFYQGAFDISVDLHEDILLSPLEKLAHTEYLDLIDRGGMKTPSSNVVFSLSKKFAQSVMLLFLKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UG23</accession>
    <name>A0AAV6UG23_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000461">
        <property type="protein sequence ID" value="KAG8182510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UG23"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043395027" evidence="1">
        <location>
            <begin position="17"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="455" mass="51492" checksum="2D24FFD93818485B" modified="2024-11-27" version="1">MNQVLLLLALATVSKAGLLEPGLLDPRLRPDSLQGGFHHRPPYDSTIDFYKARYYAKKAYDIATLRNKIFGLGNGFYGYRYGSNFRKPHFGSFPEYLGLKYQSSGLAHPNFYGKSVRFHGPTNYGSSYSQNFASGKGYSYSLSKLQPSPIDYNLPRHFKMNPLSPGYKYSYFVQGPFSKFGTQIPFKGYNTIYGTRYTGFPSQLAQWKSKVPSWYDFPMTNVPGFKGYDTIYGMKYTGSLGPFVQWKSKVPSWYNFPMTNKKVQSWYDFPKTNIPGFKGYDTIYGTRYTGFPNQIPSLTSKVPAWHMFKDFKGYPNVYGHVSSGFPSQNIPSMLDLNYGPLHFDIPNKKETIFDVKFDTVDSGVTHPKGTVLINPNYNPSFHNKGTGYDLNYRAIGPGVISKEGEEFFNENPVPELPVVGFTFPNSGNTEPEKLAIPSGVDFHEAPGHYELNHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UH17</accession>
    <name>A0AAV6UH17_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000431">
        <property type="protein sequence ID" value="KAG8183113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UH17"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="172" mass="20047" checksum="ED663C9E205F8F92" modified="2024-11-27" version="1">MYTVHPKNDECFYLRLLLVNVRGPTSFESLRTVNATVFPTYRDACEELNLLENDTHWETTIVEAIISASPNQIRTLFALIISTCFPSNPSKLWHKYKDNMSEDILHQIRGSSRNPDLQMNEEIHNQALILIEDMCYLMCGNLLVRLGMKVPNREMNDALNRELERESEYDHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIG4</accession>
    <name>A0AAV6UIG4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Hephaestin-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_011522</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000390">
        <property type="protein sequence ID" value="KAG8184024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIG4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04200">
        <property type="entry name" value="CuRO_2_ceruloplasmin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000002">
        <property type="entry name" value="Hephaestin like 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043585799" description="Hephaestin-like protein 1" evidence="16">
        <location>
            <begin position="26"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="18">
        <location>
            <begin position="106"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="659"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="18">
        <location>
            <begin position="849"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="1008"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8184024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1111" mass="126451" checksum="C63E94D132349866" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIQ5</accession>
    <name>A0AAV6UIQ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_013705</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with Ote.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000389">
        <property type="protein sequence ID" value="KAG8184071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIQ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000280">
        <property type="term" value="P:nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000010">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="249"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8184071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="456" mass="51766" checksum="8379AD6D7D074096" modified="2024-11-27" version="1">MPREMITLQLGQCGNEIGSAFWKQLCKEHGINPEGVLEDFATEGTDRKDVFFYQADDEHYIPRAVLLDLEPRVIHKIMNSEYSKLYNQENIYLSETGGGAGNNWAVGHSQGEKLHEEVFDIIDREADGSDSLEGFVLCHSIAGGTGSGMGSYMLERINDRFPKKLIETYSVFPNQDEISDVVVQPYNSLLTLKRLTENADCVVVLDNTALNRIAVDRLHIPNPSFEQINTLVSTIMSVSTATLRYPSYMNNDLIGLLAPLIPMPRLHFLMTGYTPLTTDQEVASVRKTTVLDVMRRLLQPKNMMVSTAYDRLSNHCYISILNIIQGEVDPTQVHKSLMRIRERKLAQFIPWGPASIQVALSRKSPYIPTAHRVSGLMLANHTSISSLFERTLMQYDKLRKREAFLEQFKKEAMFQDNLSELDNSREVVQQLVDEYKAATNKDYLTWGMQQAEKQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJV1</accession>
    <name>A0AAV6UJV1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000374">
        <property type="protein sequence ID" value="KAG8184397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJV1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8886" checksum="EFE9EA97D8ACE339" modified="2024-11-27" version="1">MTSLWAAPDPSLDTVIEVQLRHNFRVQWSRGGFVSLVGEDTSIHNSLRRRQIDRWGSGSGRGDHTPAKPQQFQRYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKA3</accession>
    <name>A0AAV6UKA3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_013209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000382">
        <property type="protein sequence ID" value="KAG8184233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKA3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005722">
        <property type="entry name" value="PRK07539.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005725">
        <property type="entry name" value="PRK07539.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8184233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27325" checksum="4E5B31463B76DE43" modified="2024-11-27" version="1">MQSLARSVFQHGRRCLLAQCVQSSAPVSTSSKLLSDKLFVHRDTDQNNPNIPFEFTKENLKRAESIIAIYPEGHEAAAVIPLLDLAQRQFGWLPISAMNYVADYLKMPRMRVYEVATFYTMFNREPTGKHHVQVCTTTPCALRGAEDVVTRVKKNLGIDVGQTTKDGQFTLTVVECLGACVNAPMIQINDNYYEDLSLNDVDEILNDIKAGKTPKAGPRNGRLACEPAGGLTSLTEPPTGPGFGVQPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UML9</accession>
    <name>A0AAV6UML9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA 3'-terminal phosphate cyclase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_008932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000327">
        <property type="protein sequence ID" value="KAG8185662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UML9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000001">
        <property type="entry name" value="RNA terminal phosphate cyclase-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="179"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8185662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40720" checksum="00D06C911234F967" modified="2024-11-27" version="1">MSNLKYHGSNFFRQRLILSTLSGKPIEIKDIRDAYDEPGINEYENSFLQLLDTLTDGAVIAVNETGTDVKYTPGLLLGGKLQHDCGTERAIGYFLEPLLCLAPFCKKPLHITLKGITNDSVDPSVDAIKYSSLPVLKRFIINDENLEVKIISRGLPPEGGGEVLFTCPVINTIRPLKFLDPGKIRRIRGYAYSVRVSPAMASRMVDKSKGLLLKFLPDVYVYTDHFKGKNSGKSPGFGLALVAESTTGVFYSAEAISKPSGSKGDFLVPEDVAQQACFNLFEEINRGGCVDSNNQSLACVLMALGPTDVSKIKTGPLSPYTIQFLRHMEDFLQLRMKLETEKDEKLLLGTHKVSLTCLGIGFTNLSRKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPU5</accession>
    <name>A0AAV6UPU5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ionotropic receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_013002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000340">
        <property type="protein sequence ID" value="KAG8185311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPU5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8185311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="47232" checksum="2E4A552CF23E0085" modified="2024-11-27" version="1">MYFPDKLRLIVTVANGFVAYNKSGYIIMRPEFYMLDYLSKRLKFNYEITEATPDALLPGLKEHFDIGMPYLFMYEKFFDYVHFTVPYHVTKTIFMCEKAGETPKFDAFLYPFHFDVWIFCLCFALVATVVSKYMTSLKQQSVNIFLNLVGSLLKQPLNVEINTLKKQIWWATWLVCAGVMSFLYNAIFLNFLTIPINTHNPKNFQELSEAVQNKKLECITTLNQKNHLLESREEHLRLLGEIITKNEWYFEDHRIHPIVSKTKCWIDIDQILKLQSYIPPKILHFSDDNLKMFYHVVFVRKSFCCFEQLNNAVLNMIEGGFAEKFYADYLNIHVNWRKELRRLELPDHSVQALGMEEMKYPIYLLLFCYTFCIIVFLFEILLPKTIMLTILSNKYVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ66</accession>
    <name>A0AAV6UQ66_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000302">
        <property type="protein sequence ID" value="KAG8186432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ66"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="8592" checksum="9DBBF24A305362AA" modified="2024-11-27" version="1">MKVVHCIHQKTLGALKGGPTIYSDISSFAMQPLPRKRTRQGAPSRGYPALGFVNCLTPNAPPADTSKLPSFSEDILITPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URG0</accession>
    <name>A0AAV6URG0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_004408</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000322">
        <property type="protein sequence ID" value="KAG8185866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URG0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF29">
        <property type="entry name" value="METASTASIS ASSOCIATED 1-LIKE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ELM2" evidence="8">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="136"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="591"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="517"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8185866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="776" mass="85579" checksum="DF4C89216184E840" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USF6</accession>
    <name>A0AAV6USF6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000297">
        <property type="protein sequence ID" value="KAG8186545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USF6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7665" checksum="235C390489D423B0" modified="2024-11-27" version="1">MTAVHSLLRGCGRTDKQNGSLEQNPEKELNSWWERRTATAKGGGWRIEVCDVIMNGGRGKSVRKTLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UST7</accession>
    <name>A0AAV6UST7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIP41-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_008432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000268">
        <property type="protein sequence ID" value="KAG8187545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UST7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8187545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="275" mass="32217" checksum="EC78D2E3F8ED361E" modified="2024-11-27" version="1">MAIPGNACQNSFRFESWTVESKKSHILQSRCTEDSCKTINDEKCALENASLCDFCLYETKLELPQLPEMTFAGNILTLNHDSAFGIEFNALDALLMVDSKHDNMKVAIAEAWQESRMENSKIKDVVKPFDWTYTTHYKGTLFGNTEKIKISQTEERIDLEKLKVKSKILFYEDLILFEDELADNGTAQYSVKIRIMPDSFFILLRFFLRVDNLLVKIIDTRYFYEVGKKYILREHMTRESKIKDLNVPLQLLRNPQELWEHLPKVAFEYEKLEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UT67</accession>
    <name>A0AAV6UT67_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_005743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000282">
        <property type="protein sequence ID" value="KAG8186969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056870">
        <property type="entry name" value="TTC3/DZIP3/RBM44-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043866">
        <property type="entry name" value="TTC3/DZIP3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056871">
        <property type="entry name" value="WH_TTC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17550">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TTC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17550:SF7">
        <property type="entry name" value="RNA-BINDING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24905">
        <property type="entry name" value="TTC3_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19179">
        <property type="entry name" value="TTC3_DZIP3_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24812">
        <property type="entry name" value="WHD_TTC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="2001"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="878"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1718"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1856"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1336"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1410"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="916"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1720"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1768"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1822"/>
            <end position="1831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8186969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2053" mass="229205" checksum="6A9225C7484C15BE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU06</accession>
    <name>A0AAV6UU06_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000278">
        <property type="protein sequence ID" value="KAG8187118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU06"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11610" checksum="D23B79858D5AC139" modified="2024-11-27" version="1">MRLLITRGYVYVPNTALALGTPPKDFPRLPVGTVRRGSSHTHTTQIREVRALLHFPLLDFPRLPVGTVRRGSSHTHTMQIREVRALLHFPLLASKTNRAEHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVK2</accession>
    <name>A0AAV6UVK2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000241">
        <property type="protein sequence ID" value="KAG8188346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVK2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="240" mass="27094" checksum="1B4E459EABC49F0C" modified="2024-11-27" version="1">MVVLNVFSVKHLTETGEHVVEGPAVKARNELIHIRDVSGHHGSVLMIVGKTPSPSWTTCSLMSAIETQTSSHIKNIFQDHGKCRADRRAYNLECQQFKQKKRVILHDETFSMIMAMVHGPGHFHGLVDETSSPNGRTYFGMSAIKTINESARNPIKNFFHDHGDVLMIVDTFSNDQEDVLPVRRLAQAGEHVPERLQLKHRQVLISRTFSSIMANVLPVERLAQAGEHVLECQKFKQKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVS5</accession>
    <name>A0AAV6UVS5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000260">
        <property type="protein sequence ID" value="KAG8187763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVS5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="114" mass="12912" checksum="EEF5D1F6D148D970" modified="2024-11-27" version="1">MPGNTLQLDTLIQNTQEPPKSLTQTLTNKNIPEAHPRTKPQLIQKEKRNRLEHFLALKREIRGGMGMRKSRKWLGSFESSPLPHKGLNGWGDDMLLWRVTVALCGRGIMLLMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVT1</accession>
    <name>A0AAV6UVT1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000257">
        <property type="protein sequence ID" value="KAG8187888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVT1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="10554" checksum="8CDA0CD06A51B895" modified="2024-11-27" version="1">MTKDPSSSPSSSPLNLGHGYRDPTLSLKFPFLISVFLNRKYLKTSTTTSQVTAVVSAAGFTRKETSSVGFLAISQQVGDGPRGSSGIANQSTRWDAEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXY1</accession>
    <name>A0AAV6UXY1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000224">
        <property type="protein sequence ID" value="KAG8188999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXY1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="233" mass="26928" checksum="1DB581A9082BC626" modified="2024-11-27" version="1">MVITSSSFHQNHLSNGVIQLIIEAYTEEMLRELESVAEFQLSASQSSLLRQRMKSLYDHIRQHPALHQRYLWVGKGRPDIDPDIRTPPKKSRATSKRKRYLSEDDSEPATSHESQASPASQPAKKAAAFPAEEICKTNRQWEQINSTHDFYDNEVEVIQDSVQQYVFSYRCVAETGPCIGISPLYESECTERYGWMYMYYRRTDDPFRTPQWGFVAAPHHCACKITPKYIPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1K4</accession>
    <name>A0AAV6V1K4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000178">
        <property type="protein sequence ID" value="KAG8190647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1K4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="8246" checksum="CCBDB5FFC7CDFD27" modified="2024-11-27" version="1">MNKKKISRMNLCRLGSHSHRSLGYIRLKVPAQRDESVFYRIALKRVFGNLVDFGRKVQAHRSARMNLYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2W0</accession>
    <name>A0AAV6V2W0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000169">
        <property type="protein sequence ID" value="KAG8190949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2W0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="9712" checksum="47E854880EED859F" modified="2024-11-27" version="1">MKGATTDYNSTHPIRVPLACISQIETAGSGEFFPMHTKIPCAVINEQPLEGWEYQRIGKIGGEKMIYRRSGPSSRVLSNGGLGFNRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5H0</accession>
    <name>A0AAV6V5H0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_019605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000158">
        <property type="protein sequence ID" value="KAG8191541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5H0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="52"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="276"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8191541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="338" mass="39283" checksum="C385375BB746D9C8" modified="2024-11-27" version="1">MRPIVERGEAQRLLSMSEASSPIPSNYFDGFRLPGMFSKEAVQSVIDYKPRDDDIFIVTYPKCGTTWSHHTLALILRHGENFGENFKLMDSGPFLEMTGMEASTKVPRPCAFRTHLPFRLVPWSDKAKYIYVTRNPKDACVSAFHHTQNIPGMDFKGTFDDFFEKFISGDIDCGDYFDHLEGWYKQRNRPNVLFVTYEEMKEDHEAVILKMASFVDDEKYGEPLRNDQQMLDNVLKYSSFKEMKPLLNKSMDDFFAMSANNAEKSKMPESIQNMLSKVSETKTDEDVAGKPKSCNFVRKGIIGDWRNHFSEEQSRRLDEKFAERTKNIEIPEIWKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5V4</accession>
    <name>A0AAV6V5V4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000150">
        <property type="protein sequence ID" value="KAG8191857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5V4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="137" mass="15929" checksum="0DA565F71A669F13" modified="2024-11-27" version="1">MAPHTTTPKRHHHDLMILLLIILKPKKRERKKKEMRPKESIAYPVEKQCSKPTIPRSASRNETFGAEQLFIDRDFSLAPLMIKRRKSGDLILFIQALRCRVARKRSLFSQSQLHLFQTNRNHNSISSKTTNLTGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7G1</accession>
    <name>A0AAV6V7G1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7G1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="121" mass="14244" checksum="6319FCA72D0528A4" modified="2024-11-27" version="1">MPKSHPSPVDSVITKGFRTRQAANQRRIRTTEVQSKEEKKSNSMLDPCQENEKNDVRREVQVHFPLLDPRDRNLSLTSTLVKLIKTWPLQDFLKKELKRKRKIIIPRKEVAGIQTRVKFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7R7</accession>
    <name>A0AAV6V7R7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PHD finger protein rhinoceros</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_002249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May function as a negative regulator of the EGFR/Ras/MAPK signaling pathway during eye development.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the JADE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000148">
        <property type="protein sequence ID" value="KAG8191979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15573">
        <property type="entry name" value="PHD_JADE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000004">
        <property type="entry name" value="Jade family PHD finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000030">
        <property type="entry name" value="Protein Jade-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF160">
        <property type="entry name" value="PHD FINGER PROTEIN RHINOCEROS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="219"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="271"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="588"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="676"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1021"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1034"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1061"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1101"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1149"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1175"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1191"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1211"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1230"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8191979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1415" mass="159356" checksum="F70B7C94519FDB86" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8W8</accession>
    <name>A0AAV6V8W8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_006981</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000128">
        <property type="protein sequence ID" value="KAG8193150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8W8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11367">
        <property type="entry name" value="RNase_PH_RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="197"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8193150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="289" mass="31282" checksum="18976A78B5FDF019" modified="2024-11-27" version="1">MTNFILQEAEKMYIIHGIQDNLRGDGRACLDYRTIEIETDVIASCNGSSIVKLADTKLLAGVKAELATPRPSAPDKGWIEVSLESTPHAHLEFEGRGGEEFASDVGQLLSQVCNNDKLLDLGKLCVIPGQQVWVLYVDIMVLGYGGNYIDAAAIATKAALYDTKIQSATVKCDGENEPEIEISDDPYDVFSLDVTKLPVLITLYRVGSEFIVDASGEEEACSICKLVLAVSPTDTALMRQFGGSGSLHIATLQDGIEVGQDIGISLQMQLLNSLKTEKSLPKKKRSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDE7</accession>
    <name>A0AAV6VDE7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_005024</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JAFNEN010000115">
        <property type="protein sequence ID" value="KAG8193726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDE7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="267"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8193726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="315" mass="35900" checksum="DA0503F7B3EDF76D" modified="2024-11-27" version="1">MTNFVERRPFNLMGMFDGLEEYLNTGDPVVREWFMVKSNFWPIFLCSSYLLIIKVIGPAMMRDRKPFELRKTMMLYNIFLVASYAACVSVVGYGIAMTGPTALCKNTLVTRKDYTYVMAASGWVIYLLKYAEFLDTIFFVLRKKDKLITNLHVIHHASLPICGWIFFRTERSGFQAYPILINSVIHIVMYSYYALAAMGPQVRKYLWWKRYLTIAQMIQFILIISFVTVIMPLTGCTAAKSSIYINVIAAGLFFALFYNFYQTSFKPTKPKSSRTNGKSVEETNGNGETNGYGKGQNGCKNGEDIANGQSKVKCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDV3</accession>
    <name>A0AAV6VDV3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000095">
        <property type="protein sequence ID" value="KAG8194970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDV3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9700" checksum="A3F09EB4EC5D28F0" modified="2024-11-27" version="1">MTKLVVLLVDIYSVFLRTHKHHTPPSSQISVPSQIQSIRLSSVDPSPPFPSSASLQHPIRWADGAPRCYLLHSDAGKLLQWRFNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEL7</accession>
    <name>A0AAV6VEL7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000092">
        <property type="protein sequence ID" value="KAG8195147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEL7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8312" checksum="E1F28EE7F49FCC75" modified="2024-11-27" version="1">MDKGFSWFPQDMESPLNGSVKDNGYLQVSSASEDLTRVVIGLSVMSLLEWRVWLVLMASLERLSMNYSRRIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF92</accession>
    <name>A0AAV6VF92_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin carboxyl-terminal hydrolase 32</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_001395</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000089">
        <property type="protein sequence ID" value="KAG8195379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000081">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000018">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057368">
        <property type="entry name" value="USP32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF76">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25265">
        <property type="entry name" value="USP32_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="229"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="265"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="15">
        <location>
            <begin position="374"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="14">
        <location>
            <begin position="763"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="488"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1052"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1453"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1056"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1107"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8195379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1624" mass="183442" checksum="FD2E2A273C4B00EE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFS6</accession>
    <name>A0AAV6VFS6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Neural cell adhesion molecule 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_013268</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFS6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009138">
        <property type="entry name" value="Neural_cell_adh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF27">
        <property type="entry name" value="NEURAL CELL ADHESION MOLECULE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01838">
        <property type="entry name" value="NCAMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="113"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="208"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="304"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8194516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="48806" checksum="827A884E10818BF9" modified="2024-11-27" version="1">MSPEYCPEHQSKNGSCSQLYLQPVKNDHAYFTGDNFFITCFTTDENIDKLTWTDFDNNPISTTEGRIHAQPAEGDQLGLRLVFTNVETEDAGTYTCSDDQYSVNFDLIVYRALSFSDTPSEQHAPEGETGIVLCNVKSDPKPVVNWYFNGNKISNNQKYKIHPENHSLKIQNLTRKDAGEYKCKAFVITSLSSQVKDFDIKLHVQYIPEVIGEHKVVSYASIGMKKSLTCTVTADPVPLFEWLHDDMIIYNNSKSFVIYNTVNTSTLHMVVDDDDRLGEYTCRASNPLGTKEVIIDLKEGDTPPPPAISVAGQDQGIVKLNIKAQEDNKVGEELKVTGFKVEYILASETWDSAVSQAFVFGESYELKNMSFNSEYILRAAAYNAAGYGNFSAEYPYKTHSLQTASVISSDAVDLKILFYEKAYLLCMAISILLVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFZ5</accession>
    <name>A0AAV6VFZ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_021399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000096">
        <property type="protein sequence ID" value="KAG8194938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFZ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206">
        <property type="entry name" value="DEP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206:SF19">
        <property type="entry name" value="DEP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="35"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8194938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="498" mass="57979" checksum="72C652E4A0583C9E" modified="2024-11-27" version="1">MEDSGRNFESLSTIQPNIRRLDPFWATRLWQRLIKEALVKVKVCRQRHFLKNYDDVFNGEDLVDIVFQFLKECTSDLDVQRIDRSNAVKVCQVLMDKKFFESVISKDNQKFEDSSNRFYRFIHDQTAEEKPLKEEFQKNDTSKIIQEEKENAVLSPYNARSFTPDAKLSLKRRSIRLKTPMLRVRETKPSPVRFSKRMSRDADQEDSQELRDTALALLLQLTDIPMIENILSIPFDLPEIPEAPRPFVLENDLTPRKVQPTTDFRGPIADIPWVKAASQCMEGKHPAGIAGIWSLQACKVLCYRSVVERFSLPVESLIPWHYFPVCIAIVGMLKDGRRQHALYALQLLVFHLPWRRRKQLQHLLHFLRLVVDDIFVSVDKKVTNYEAVQNDFRVTVFKHPLVSNEHQKILFDFLLLKSEVIFQIPATLHTIKEAGMRFCKPSAEDSPNSASNFTKQCLLDLAFSVVDSTDIKLSEKKVFLRRLKKHHPKAHEACKFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFZ9</accession>
    <name>A0AAV6VFZ9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000080">
        <property type="protein sequence ID" value="KAG8195720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFZ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="104" mass="11625" checksum="0D6802FB786EDC3A" modified="2024-11-27" version="1">MSDKHKNYSMSWSRVTVRGPRQDTDHTSTHIDISANKDPEIKNTPTFGGSFFRYSREGTLQVRHSIPLVELNCLATADLYSSYPRSSVFVCGVFNQLGVRANGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHJ5</accession>
    <name>A0AAV6VHJ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_013603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000093">
        <property type="protein sequence ID" value="KAG8195131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHJ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001336">
        <property type="entry name" value="Epithelium specific ets factor 3, ese3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF190">
        <property type="entry name" value="ETS-DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="265"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8195131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="363" mass="41595" checksum="91975138EBF2D18D" modified="2024-11-27" version="1">MLSPDLAPDLQFVGSDVPFYDNDIVKKEMQYIDLQPPMLSQNSNQYNNSVIMEYMFPNGTNDDLQWETTRPWQYKPPNQWTESEVLEWLINWSRQTGIDLLELNCMPELNRMNGQSLCALTQSDFYTLDHQYGPLLHQSLQNEIANHHYQLSPTSMDIAASLRADNPLPAFHTWSNDTYSQLLSVVGSDIQGSSPSSSHDSDREDRESTSSSMSTANEKLALNNPEYLMTTLCPEITDAKKPGRRGRPPKSEARSSRSRQGKGNGKLWEFIRDLLLDPATNPSLIRWERPEDGIFKFVQSDRVAKMWGDRKQNPRMTYEKLSRAMRTYYSSGILSPVPKTEGLPKKLIYKFGPKSSGWLRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKG5</accession>
    <name>A0AAV6VKG5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_009597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000071">
        <property type="protein sequence ID" value="KAG8196382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKG5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043518337" evidence="3">
        <location>
            <begin position="24"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
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        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8196382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="811" mass="92274" checksum="D824C061DC62AA34" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKR8</accession>
    <name>A0AAV6VKR8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000069">
        <property type="protein sequence ID" value="KAG8196487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKR8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043787105" description="Glycine-rich protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="15538" checksum="B46EA96369242C55" modified="2024-11-27" version="1">MIRKLLAATLVALVLCSCVRDAEAGHKLKLKKIAKMLLMANALTGKKILFPLPLPLPIPIFQEHVKHVPYESMGGYGDMGGGYGMMGGGGGYGMMGGGGGYGMMGGMGGGYGGGMGGGYGGGMGGGFGGGMGGGYGGGMGGGMGGYGGGNMKGGGMGGGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLQ6</accession>
    <name>A0AAV6VLQ6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000054">
        <property type="protein sequence ID" value="KAG8197524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLQ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9254" checksum="12A120CCFB24B5C1" modified="2024-11-27" version="1">MPKHNTKSYPLLHELIPPKSNTGYHPLSKPGASDNLKGFVSYPTVLNIIPSSFIGKDDNCSQLMPRLSLSHEYMNGKCVLSPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLV4</accession>
    <name>A0AAV6VLV4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hydroxylysine kinase</fullName>
            <ecNumber evidence="8">2.7.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_001555</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19049"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57882"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58357"/>
            <dbReference type="EC" id="2.7.1.81"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.81" evidence="8"/>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLV4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047992">
        <property type="term" value="F:hydroxylysine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050249">
        <property type="entry name" value="Pseudomonas-type_ThrB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064:SF1">
        <property type="entry name" value="HYDROXYLYSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="10">
        <location>
            <begin position="75"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8197624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="390" mass="44476" checksum="24C3296225E308FA" modified="2024-11-27" version="1">MSNTEPSNSEVLGKIISEMFKPHVSKELAIELASRLYGFEVTEIKPLNSFSDQNFLIKVSKHHQNPHIEEISDEGYVLKIINTYKSKMENHFESVHAGIIHLFKKGLRVPLPIKNLEGKTWTLERVPLQEKEERKANKDMKCGIHLLTYIPGVPMATFKNTADNFFEWGKLLAEFHSALEDLDCPSLKTKDIFSNVKFFSNVGAFLESQEDQELKTLVHNVLERYPSELLVHLNNVPQGYLHGDFNDHNVLAQLKHSAAAAEYRADGILDFDDLHYGALVWDLGLMLGHVPMVDKDIDDLEAAGHAVAGYRSVRHLNELEMSLVKICMECRLSMMTFVSIATKDDPNNSYIQLLAATEPKRNMLKRLAKINVDELLDIWNRTFRKHNIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMA3</accession>
    <name>A0AAV6VMA3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMA3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="141" mass="14750" checksum="4A4E76B2F9EC8C84" modified="2024-11-27" version="1">MPKVTLFGMPDPSPGNLRICPNLTELSTSGNPPDPPGLTHSSSVTSLMSENSPHLTLPHRSLFPSKPSAHLPGCPSLQSGSSSVYLPPAPMMSHSTKPQLRGPLAALSATGPLDVTGSLMDPCLSRSIHQHKQVTSDEAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPS0</accession>
    <name>A0AAV6VPS0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Speckle-type POZ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000036">
        <property type="protein sequence ID" value="KAG8198712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPS0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="21"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="187"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8198712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39114" checksum="D2944CEBC62DF28B" modified="2024-11-27" version="1">MGGTTSLEHKTALCDGVPVDKYVYVWTVSNIQKYLSNGVGYKTQTSVLTLNSDETFRVVLYPNGFNERTNGYASLWLQKLSSNEKLLRFTCAIVGDDGNKVLKKTIKKQLGIESFIGWMTFFPRNILIEEDPSVLVNGNLILKCSVQMCNDDKLLGNPENEDSVIANSVLCGLSNNFMSLWADEAYCDFSIYVQETKFAVHKAILSARSPVFRVMLKSQLTNTDSITITDISEPIVKKMLRCIYSGEVGVLDFEAASELYYAADKYQIILLKSVCFNIITKKIRVDNVLSALLLSENHSDYELREICIQFVVKNAPEVHELPEWMEFLKSQPHLANVIFRRLAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQI7</accession>
    <name>A0AAV6VQI7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KRAB-A domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000034">
        <property type="protein sequence ID" value="KAG8198915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQI7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="32711" checksum="15DE8B428B93043C" modified="2024-11-27" version="1">MAALTALLQEKARNTLLYSKDKYYALLAEVKQAKVRHRKESVDYRRLKKYDVLNVNGEERLIVPLTGDNSMVLYYVHVDELFDILHHTHLVLGHRGRDSMERELQTMYKNVTKEVMMLYLRFQLATYDGPAFAMKIKFMNALNTLLQEKANNTHLLTKEKYCAVVEEVKQAKVKPRKETVDYRRLKKYDVVNINGQERLIAPLTLDSSVLLYYVHTEELFDIVHSTHLATGHRGRTRMEKELKAKYRNVTTEVIMLYLRLCEPCQKKLAEHKTQYQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQW2</accession>
    <name>A0AAV6VQW2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="6">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_021526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="6"/>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQW2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090433">
        <property type="term" value="F:palmitoyl-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="168"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8198272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="764" mass="85927" checksum="6B325BCDA0D78980" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VR96</accession>
    <name>A0AAV6VR96_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_021527</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VR96"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF83">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8198273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="548" mass="64888" checksum="BFF6B443892F24CB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS56</accession>
    <name>A0AAV6VS56_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000039">
        <property type="protein sequence ID" value="KAG8198504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VS56"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="9237" checksum="CBF51303820A34F3" modified="2024-11-27" version="1">MRDDRNDKLEQKISSIYNTEKIATIQLLSNNLRSRASGLIRDELGGDRRFKQVIDNLNSFQSLDTILIPYEDTRVALVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSB1</accession>
    <name>A0AAV6VSB1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_023490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000036">
        <property type="protein sequence ID" value="KAG8198722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSB1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000508">
        <property type="entry name" value="Sodium-dependent glucose transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8198722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="559" mass="61511" checksum="BBA21DF5DF9D115E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSJ4</accession>
    <name>A0AAV6VSJ4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000032">
        <property type="protein sequence ID" value="KAG8199055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSJ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="8093" checksum="3B9C22512B6B8F67" modified="2024-11-27" version="1">MKIKRPNINQQSTKNHKENNRQLAHVMSSRDRTKDNGDFVDSWTKDVTTLQQLGEKRQHWIKGYDNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT03</accession>
    <name>A0AAV6VT03_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT03"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF19">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18891" checksum="B3CB2A58B8854664" modified="2024-11-27" version="1">MSSTGKISEFHPESDDAATYVMRLKHFMVANKIEDNNKLSVLITVLGSKVINTLVDLVTPDELDSKTYDQIIELFLNQYKPEKLTVAERNIFNTRRQKQFESVQEYIIVLKHLASMCKFGNFLNEALRDRLVSGVLDEELRQKLIIEDITFTKACEIAVKYEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT71</accession>
    <name>A0AAV6VT71_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000020">
        <property type="protein sequence ID" value="KAG8200112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT71"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="9239" checksum="D818ABEE8C445522" modified="2024-11-27" version="1">MKSLRTLIPLPPNTTAHKRTQSSTLTIPQNLTFPSELSSERSAIRLTLTGKVSYARAFNGFCVWVLVTRGACAFGDNRPFEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VU69</accession>
    <name>A0AAV6VU69_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_011804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000028">
        <property type="protein sequence ID" value="KAG8199338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VU69"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039986">
        <property type="entry name" value="CFAP210"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28663:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA- ASSOCIATED PROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28663">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="507"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="570"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="170"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="278"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8199338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="78342" checksum="DFECE28E2DF45283" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VV48</accession>
    <name>A0AAV6VV48_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_022133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000025">
        <property type="protein sequence ID" value="KAG8199683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VV48"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="2">
        <location>
            <begin position="61"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8199683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="382" mass="44385" checksum="34A017052CD5BB99" modified="2024-11-27" version="1">MQNHFSSYRWRRYVPFLVFATVVAIVQLYAIAIKDPHFIKNAIQTLSNTKNRGNETLGPLHVLLVSYARTGSSFVGDLLQSVPDTFYHFEPLHFISNPVLNSSFDDARVLLNKVFNCNVSSIKGYLPWIQLHKEYMKLKRSLNYWKECSKKKKNLCFNASFVDSTCRKHKTVIVKTIRLKLREASELFLTHPNLNLKIIYLMRDPRGSINSRMKFPVSMWCKKDPMCSNPKYYCDSLAEDMKVACGLLKDRPEDFLIIRYEDLALDPFGTTDRLVKFLGMPSMPRDVEIFLKTHTSVIGSVREKYRTQGVDYAYSTFRNSSITAMSWRQQMSFKRVTQLQNYCQTTLTGMGYYPYYTVSNLRSNVNFDKNNDDAIRSYCSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VX94</accession>
    <name>A0AAV6VX94_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor AP-2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_019883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000007">
        <property type="protein sequence ID" value="KAG8201244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VX94"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF17">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01748">
        <property type="entry name" value="AP2TNSCPFCT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="8">
        <location>
            <begin position="254"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8201244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="477" mass="52675" checksum="08DADA949566EBBF" modified="2024-11-27" version="1">MAQVSPLSVVTHDSPVSKRKGTPDEDIGSVEVSGQLSPDHSVKASDIQSAFALIDTGEDRRELVVSHVGNLTSISSIIPGTTTFTTGARLNHEFQPPYFPPPYSSLAQQPTQLDFNSDPYGPALTAPQANYHPQLHNSRNLFKREDEATLHLQTTNMLTYADSNRARTDLGSFARRPDILVHSAHTLTDQDIINLHNAGALAALDDGQTTTVDESSLFGSEHNSVIRKGMKRANNENNHKDIMMTGLTSTQEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAIHLARDFGYVCDTEFPSRQVAEFLSRNYTDPAIIYKRKQELQDTREIIKEFAEFLGQDRSPLCNTKMNPILPQQIQRHLTHFSLITHGFGSHAIVSALSAAQNYINESIKYLDKQLSNYQQVSQDVTGLMDNKKDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VY09</accession>
    <name>A0AAV6VY09_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_000524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052424">
        <property type="entry name" value="Kielin_Chordin-BMP_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698:SF3">
        <property type="entry name" value="TENECTIN ISOFORM 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="77"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="1220"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="399"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="490"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="785"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="876"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1029"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1186"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1394"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="803"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="877"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="932"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1030"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1061"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1394"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1424"/>
            <end position="1438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8200441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1618" mass="179872" checksum="1607661FBD8E350C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W259</accession>
    <name>A0AAV6W259_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_010382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W259"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043709025" description="Right handed beta helix domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Right handed beta helix" evidence="6">
        <location>
            <begin position="139"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8202011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="415" mass="47522" checksum="2EC16B2E63AC1C16" modified="2024-11-27" version="1">MEKIDSKKMYLLLPLLFFIGSARALETESSVTISDLCTIDEDPDSSIPFVECLCSNRENFTYTSLFVYNINRITIKGCGSVHLGFDSLSNLHLKQLSFVDLQSLTLQTFSLFWTEEIENLKIEDVGDLIIQQHAFSGLRNVDMVTLKNVTVQRLPKEAFSSIANVRLMIIEGSAFYYIEQLAFVVQNVTILKVIDSEFHALEDSSFFILESDVVQFKDCTFETTDNQTFVISRVDSISFYNCSFEDLAPNSVQTHNVNTISFTNSVIEVLHPDAFTGLKVVEKIEFKWNTIRIMYNNSLEPILAPELKYVEVDFCCNSFTCDCNIFWLWSLKNREILENSTCIEDLSTTVSLYVPILDSENICMTLELKSSQYEYHGNTSYKVMIHHMGKASTASPFQLMLFIIIGSWFSYYFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W4Q5</accession>
    <name>A0AAV6W4Q5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-arabinono-1,4-lactone oxidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_027401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W4Q5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF8">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-arabinono-1,4-lactone oxidase C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8201924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="9065" checksum="336E4C130EDBAF68" modified="2024-11-27" version="1">MYRPYGKDVPYQEYFQAFERIMMEAGGRPHWAKAHAVTSEGLKTMYPFFGKWCLIRQKLDPIHMFMNPYMSRILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W4W0</accession>
    <name>A0AAV6W4W0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_027389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W4W0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21092">
        <property type="entry name" value="TPT_S35C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="62"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8201911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="408" mass="46418" checksum="8EB5171D65776660" modified="2024-11-27" version="1">MKRRRESSLHRNSSPNRQASFMSYIRHFNVCCFPCPDVYNPKMKSLDRFCTVRLILAFIRTLGLVCLYYCFSIGITFYQKWFIKDFHFPLTVVICHLVVKFMLSGMLRCSYQIYTGRQRVVLDWSTYFKQLAPTGIASALDIGLSNWSFEFITISLYTMTKSTCIIFILGFSLLFGLEKKRYSLIIVVILISAGLFMFTYQSTQFNLEGFLLVLSASFLSGLRWTLAQIIVQRKDLGLGNPVDMIYHVQPWMVLGLLPLAVIFEGLPIATTEKVFRYKESSAIYTTLGYIMLGSVIAFLMELSEYLLLVFTSSLTLSIAGVFKEVCTLYLAVKYTGDSMTTVNFIGLVVCLIGITFHVILKGLDSNGKESSSLRTVLVSCYLNSIYYFSSIGNKVLRVKRNTKDGSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TE30</accession>
    <name>A0AAV6TE30_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006300">
        <property type="protein sequence ID" value="KAG8156126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TE30"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8156126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7593" checksum="CF7A44FD46F208E5" modified="2024-11-27" version="1">MSRTVMAEKNSSPTPPVAAAPGVDVAQERNKQSPHSKLTVNTLPKQTTANEGLWVRERTKNGRENKTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGN4</accession>
    <name>A0AAV6TGN4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004083</name>
        <name evidence="3" type="ORF">JTE90_013000</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004617">
        <property type="protein sequence ID" value="KAG8170978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010004091">
        <property type="protein sequence ID" value="KAG8171362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGN4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8171362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17628" checksum="6D9DC9716C3C24FA" modified="2024-11-27" version="1">MGLAPTLGNSPGQGDLLQSPSPARSLLNATFPHALRAGDSALGFSRKKPFHHRGTPTIKGPLYLILPQKYCHKIKYETTSHSRQTVLDSPRPALHIAAGRGNNKGRKGRQASRVGHAHGIQLTPTRSPMLRSQYAPYSHRNNFRDGAARHGGRTTRREAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THA7</accession>
    <name>A0AAV6THA7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004288">
        <property type="protein sequence ID" value="KAG8171219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THA7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="9741" checksum="697EED3B77AECA73" modified="2024-11-27" version="1">MKGPQTASGLPRGDLTSQTEILSVPHLPPTPRPPKRTPAMKNDQVQQRGSLFPGGGRHHWLVIRWASPPRENIRFGPFPSRGTTELGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKD3</accession>
    <name>A0AAV6TKD3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002744">
        <property type="protein sequence ID" value="KAG8172407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKD3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="57" mass="6404" checksum="D5C75DBC34E06C65" modified="2024-11-27" version="1" fragment="single">RVSNHAVRKTYLVGMQTIIRERDAKMGNSLVKKERGNEGSKGFVSGGVEKWQTNRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPD7</accession>
    <name>A0AAV6TPD7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001659">
        <property type="protein sequence ID" value="KAG8173548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPD7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="175" mass="20423" checksum="D9D29D90057AAE38" modified="2024-11-27" version="1">MDSAKPQRKAKSMTKEQKLEKAEREKRLSTTNERILGMKRDVLKTVESMLLKDLSIEWFLENCSKLCQQDYEDVIQESYFDVLPLFGLHYRDIRDGVKKIVETFSLTLTNITFKPPEWKCISLVLLRILTQNVLNDIEDAKYLKKFSKISVQEINKLATDLVSSKVLCRLQSCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQB1</accession>
    <name>A0AAV6TQB1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_005162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001333">
        <property type="protein sequence ID" value="KAG8174070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQB1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="619"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8174070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1170" mass="128815" checksum="BDE6A5B4598EC308" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQJ0</accession>
    <name>A0AAV6TQJ0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen fixation protein NifU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_006342</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001302">
        <property type="protein sequence ID" value="KAG8174160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQJ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="NIF system FeS cluster assembly NifU C-terminal" evidence="4">
        <location>
            <begin position="174"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8174160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="248" mass="27370" checksum="8663007633276F82" modified="2024-11-27" version="1">MQYSKRLAQKIEKPLHVGAFSLVEAQSKGMRLAVGTQGNYQLGQWIKIYLLVDESDGVIADAKFQMFGPSCLIGALEAACEVLMRKNYDQAALLNADLIDKQVRDKSQIPAFPESAFSYLKFVIDAIADAVQSCRDIVLPDNYVPTPLTSLLHNQEEYPGWKELSHEQKIAILEMVIANDIRPYIELDAGGIEIKELSLDNQVIIAYQGACTSCPSAIGSTLQAIEEILQAKVYSGLSVKPDLSLLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TR53</accession>
    <name>A0AAV6TR53_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001246">
        <property type="protein sequence ID" value="KAG8174349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TR53"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="10384" checksum="DEBB185D1E80601A" modified="2024-11-27" version="1">MASLLTAIKGASEFFLGSFVTYSSALKQHILDVPKKILETKGTISAECVLAMLNGALEKSQADVGLAISGIAGPTSDSSHEKIGTMWARYARKKGSSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TS39</accession>
    <name>A0AAV6TS39_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_027101</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001216">
        <property type="protein sequence ID" value="KAG8174446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TS39"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8174446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="671" mass="76762" checksum="2121134AC2C390CB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSS7</accession>
    <name>A0AAV6TSS7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_007655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001203">
        <property type="protein sequence ID" value="KAG8174485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSS7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8174485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="278" mass="32389" checksum="FD41A79728380EAA" modified="2024-11-27" version="1">MDKEFKVEYEELGTEVRDFTVQLLSQCRDTTETEMLLQLPWGFNEGGPKIQFPRVQLALGYNQREFVAHSLVQQVLAAHWLGEFRSWPRLSLASKMLHCFVRFLMLPFLSLALAVMPWFRPLKKYHSPLNRFLLHLVSYLIFLLMVFLLNHLDTGKFHKVPPQTGVEAEVLEDRQHKRKVLERKFWRGDDAALVHEALFSVGIVLAFGNLAYFYQQSSRLGPFLVSMSRMVLQSAYFMGFCLIVITTFAIAPTRMYEFYDGMKRNDKDGNSRTQLSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTY8</accession>
    <name>A0AAV6TTY8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Solute carrier family 25 member 32</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitochondrial FAD transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_012993</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Facilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes including fatty acid beta-oxidation, amino acid and choline metabolism as well as mitochondrial electron transportation. In particular, provides FAD to DLD dehydrogenase of the glycine cleavage system, part of mitochondrial one-carbon metabolic pathway involved in neural tube closure in early embryogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>FAD(in) = FAD(out)</text>
            <dbReference type="Rhea" id="RHEA:76535"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001055">
        <property type="protein sequence ID" value="KAG8175154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTY8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015711">
        <property type="term" value="P:organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000025">
        <property type="entry name" value="mitochondrial folate transporter/carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="120"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="225"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8175154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="322" mass="36035" checksum="8386C5F65D78387B" modified="2024-11-27" version="1">MRAFVATQPKRIAPVNLFSHVKFEHLLAGISGGVTSTLVLHPLDLLKIRFAVNDGQILTRPSYNGLGNAVSTIIKEEGVRGLYRGVTPNCWGAGASWGFYFLFYNAIKAWMLESSNKKTLGAGSHMLAAAEAGVITLFITNPIWVVKTRMCLQYSTSTGLPPSKHYTGMLDALVKVYRHEGIPGMYKGLIPGMFGVSHGALQFCAYEEMKKKYISYYQLPVDDKLGTMQYLSFAALSKLFAASVTYPYQVIRARLQDQYKEYSGVSEVIKRTWRYEGVRGFYKGLPAYFLHVTPNICIVFLIYEKLTVSSEPENIFPEDDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TW83</accession>
    <name>A0AAV6TW83_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhabdovirus nucleocapsid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000964">
        <property type="protein sequence ID" value="KAG8175682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TW83"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3570.10">
        <property type="entry name" value="Rhabdovirus nucleocapsid protein like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000448">
        <property type="entry name" value="Rhabdo_ncapsid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023330">
        <property type="entry name" value="Rhabdovirus_ncapsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035961">
        <property type="entry name" value="Rhabdovirus_nucleoprotein-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00945">
        <property type="entry name" value="Rhabdo_ncap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140809">
        <property type="entry name" value="Rhabdovirus nucleoprotein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhabdovirus nucleocapsid" evidence="1">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="208" mass="23804" checksum="0F04BACC1E30178C" modified="2024-11-27" version="1">MDNSNIMEIHIARKDKLNQTIVFSDSKEEAQYTYPSDYWKTSKNQPPSISIMDVTSSQIYSLLMEDLAVSQWRDPVISTFIYCVVQEHPEIFEVTLDKDWTPKNEPAIGKKTEKINPFSLIRVTKDYPTTAAKTELPDSKKSRLSLLLCVLITYRKIVMKTNNPNQHNEGFWSTAGVQNKDKFLLYDSKAAEDTGPRVILLEVNGFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWN6</accession>
    <name>A0AAV6TWN6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000942">
        <property type="protein sequence ID" value="KAG8175884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWN6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9253" checksum="8C28C7AB6382527B" modified="2024-11-27" version="1">MVFVKKSSAAQVQLQKGTHVESKDKDTGASSKTSFYILAGAVVSLVVSVSVSGSEVSASLASTLEKRKEKAQLDWRSSEMARKQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXS5</accession>
    <name>A0AAV6TXS5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_012399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000916">
        <property type="protein sequence ID" value="KAG8176146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXS5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="47"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="273" mass="31375" checksum="4981808CF350C186" modified="2024-11-27" version="1">MKTTHKVRERFYWDKLKSDVDKWCRTCSTCTARKGPNTTRGRLQRYNVGAPFERIAIDVLGPLPQTTNGNKYILVVMDYFTKWPEAYVIPNQEATTVAEALLQDWICRFGVPLLLHSDQGTNFTSAVFTGLMDLLGVTKTRTTPLHPQSDGMVERMNRTILNHLSLFTHRNQNDWDQKLPLFLLAYRSAVHETTGLSPSQMLMGRELRLSCDLLFGRPPDDPSSPVEYLEDLKARLEDVHLFARERIDINTSRMKTRYDAKSHEPAFKIGDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZL5</accession>
    <name>A0AAV6TZL5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000849">
        <property type="protein sequence ID" value="KAG8176724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZL5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1850.10">
        <property type="entry name" value="RNA-directed RNA polymerase lambda-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22212">
        <property type="entry name" value="CPV_RdRP_pol_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1245" mass="141161" checksum="7880CB06F6AFBAD4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZT7</accession>
    <name>A0AAV6TZT7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000810">
        <property type="protein sequence ID" value="KAG8177169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZT7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="243" mass="27564" checksum="855F0FF40AAC3BD6" modified="2024-11-27" version="1">MENLTLDSIQQIVLNTEEEWEQFFKSQNNPSTNTTNPEPFVRGITKYNGKDIIGNIADQIGAEIRKGIDDSIKFIRLKEAKRENDIVYPSVRIVLDDSSKEINVKALLNGDICKRYNVKTITLCHPDQSYKRGACCYINENGERVYDIINGSYNINLTWNIEEKICNIRINVKDDGTVTLLESHGITEEELLANKEVKIGKKREAKFLHEALASQLPQSLSKSARVLVLQSSVEAYESIAQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0L2</accession>
    <name>A0AAV6U0L2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Golgin-84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_026196</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000773">
        <property type="protein sequence ID" value="KAG8177569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0L2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000301">
        <property type="term" value="P:retrograde transport, vesicle recycling within Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019177">
        <property type="entry name" value="Golgin_subfamily_A_member_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13815:SF7">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13815">
        <property type="entry name" value="GOLGIN-84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09787">
        <property type="entry name" value="Golgin_A5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="684"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="228"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="355"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="454"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="598"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8177569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="723" mass="82399" checksum="DEF40B5059156A43" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0T0</accession>
    <name>A0AAV6U0T0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000766">
        <property type="protein sequence ID" value="KAG8177644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0T0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13879" checksum="E54136C13612E678" modified="2024-11-27" version="1">MTENPTDLEPITPDMFLKDIDEVGTPDLDMIESKNLDKRLRYRANLREQLLRRFRNEYLGQLKMQFPKLKSREIMLDEIVLISSDNKKKSIQNRSLKIESSEGSARRKEVIKIWTCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0Z6</accession>
    <name>A0AAV6U0Z6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endonuclease III homolog</fullName>
            <ecNumber evidence="14">3.2.2.-</ecNumber>
            <ecNumber evidence="14">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="14">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NTH1</name>
        <name evidence="17" type="ORF">JTE90_025245</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="14"/>
    <dbReference type="EC" id="4.2.99.18" evidence="14"/>
    <dbReference type="EMBL" id="JAFNEN010000715">
        <property type="protein sequence ID" value="KAG8178132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0Z6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000003">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000005">
        <property type="entry name" value="Endonuclease III-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HhH-GPD" evidence="16">
        <location>
            <begin position="309"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="178"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8178132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="494" mass="55314" checksum="6D367B9191F1F304" modified="2024-11-27" version="1">MLCFLKTIKSFSAKSSLPVIASSMTTRTLRSSASVKTENKTLNDKETENGPNTSKYFQKKLIKKEMGVSENVKKSVKISRAPKSKPQAQRIVVKAAESDVPGIVITEPLDNDNRTSTSGDDIQTTNKPKTVANVDSTKKIKVEKKGNTKKNAIKTEQISPKKVKTEVLSDEEFASTNNHSALGFEGDSKNKIYPTTRKKQVQKPSIKTEPNSSEKVKDEPLSDQELTATAISPRKRKQVVKVEKSTKFKTEDIEDIGWQPGNWRVVLDNIMEMRKWQLAPVDMMGCEECPEKDTPPEVFRYQTLISVMLSSQTRDEVTYAATQRLIAHGLTVDSILGTSDEKIGELIYPAGFWKSKVKYIRNTTQILKDRYNGDIPRTFKDLCKLPGVGPKMANIVMSVGWKETVGIAVDTHVHRISNRLGWVPKQTKDPEQTRKALEAWLPKELWDPINVTLVGFGQTICRPVGPSCHKCLNSQLCPFGRSCLKDGFKKSPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U108</accession>
    <name>A0AAV6U108_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_024198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000770">
        <property type="protein sequence ID" value="KAG8177598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U108"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF12">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043798336" description="Spaetzle domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="6">
        <location>
            <begin position="709"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="343"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="467"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="467"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8177598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="812" mass="90870" checksum="409D7294F8B73347" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1Q8</accession>
    <name>A0AAV6U1Q8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_000799</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000734">
        <property type="protein sequence ID" value="KAG8177936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1Q8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="11">
        <location>
            <begin position="392"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8177936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="483" mass="52766" checksum="9E7010C14659844B" modified="2024-11-27" version="1">MCVTIFAERRIKIGVLSGPESSRREGSDKFWSFARPPASPLLLEPLPYRLPKWSGTEIAKAVCDAALSGARGLVVLCPRRLSALVDAYSSRLPLVSPWGGQGALHAALVPDAVGAAADIVRGDDSFAFLYDTDTGADHLSSVFSGLLQEGSSRSPPRVEGFWRVHGPNESLAFLHMVPRNTTRVIVDVGDEGAADEVARLFSAAGREVHALWMGPALMTARRSSKVSGRSTLTKLQVASGGGVSLEDLENRWKTLDDGRGDEKDMPVSTILTHDAIRVMYSMLDQLGTEWLDLNSTADEDCFNFTAGLPEGDTLDMQTLSGSGVTGPLKFDENGKRAGYTLDVIETNSFGSRKVGTWSRSSGLRWDRMQAEEQAQRLKREVPIRVTSVINRPFLTVKPGNQLEGYIPDLVEALRNVTGRPFVLVPVKDGRYGYKLDGRWVGMIGEVLFNPRSFTQVRDDPRGRSSDGFRRCTFEAASLILTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3H3</accession>
    <name>A0AAV6U3H3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000707">
        <property type="protein sequence ID" value="KAG8178261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3H3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="304" mass="33084" checksum="5F213CA4520DB243" modified="2024-11-27" version="1">MSRFTISNSDLEILNALTIANSISKNLTSNSSFEKSNSYNASYGQGKSKRTISTTFSTNDSAIGSTNDSVICSTNDGSTASTKADVTSSTNLGAFCSSSISAPLSPYFDATCSTTDAAACSTDDSIQGIFRRANQTFTSFQLDSEYQAVLQDIQTVCLMNDITTERKRELENKRAITTPSTLSTSVLRKRLENINLVIKHILTISSQVSKVKQSLQDAPYKTTLKVGPSCQEDVVKFFHTADAIIKKLQDDSSAVKFYNKSVAQVIPVDETALHSKLQAIITGLARRLDILTEFRNCLLAIEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5A8</accession>
    <name>A0AAV6U5A8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000647">
        <property type="protein sequence ID" value="KAG8179121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5A8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043529403" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11768" checksum="D0DF19BE692CE68C" modified="2024-11-27" version="1">MKTRTFLLLALFTLLSFKVEASHGASQVTSNSKTTISNRFLGFPSKPSRSRRSPQFPQMFLVQGISRPFCNLFGNAGCAPHLVSQCSGGYKYDFSAQRCRKIGIGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U605</accession>
    <name>A0AAV6U605_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein ced-11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_012073</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000631">
        <property type="protein sequence ID" value="KAG8179376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF1">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25969">
        <property type="entry name" value="NUDT9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="675"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="808"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="946"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1003"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="14">
        <location>
            <begin position="97"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="14">
        <location>
            <begin position="239"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="15">
        <location>
            <begin position="528"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="707"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8179376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1439" mass="166471" checksum="24FD9CFD7B0A0D80" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7K9</accession>
    <name>A0AAV6U7K9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_015400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000595">
        <property type="protein sequence ID" value="KAG8179950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7K9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000013">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF92">
        <property type="entry name" value="PATCHED-RELATED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="731"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="761"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="834"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="10">
        <location>
            <begin position="266"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="923"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1052"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1066"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1089"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8179950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1105" mass="124699" checksum="093DFF136B38AE34" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7Q0</accession>
    <name>A0AAV6U7Q0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Scavenger receptor class B member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">SR-BI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_019536</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Caveola</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000571">
        <property type="protein sequence ID" value="KAG8180255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7Q0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF110">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="490"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8180255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="550" mass="61668" checksum="D0051BC065DE0F42" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7Q3</accession>
    <name>A0AAV6U7Q3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000606">
        <property type="protein sequence ID" value="KAG8179716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7Q3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="109" mass="12690" checksum="A7D907DF9EF4CD07" modified="2024-11-27" version="1">MTPSSILSDFIITPSGVTDYLQFLLPEEITEYLTNSFNNFASIDEFQLQILRVSFFILCINLVFILIVWKKFGEKITERFMKPASSKSLEELKREATELKLPKEHTPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9T3</accession>
    <name>A0AAV6U9T3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000539">
        <property type="protein sequence ID" value="KAG8180974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9T3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22122" checksum="9AB2FD89D9B7989E" modified="2024-11-27" version="1">MILTQYYQECKARWAHVRDYYKRKQGKPGTGSTGEAAKRRAVLLSFLDDKNLGKRDTINSFPRETLPCADIDDLMVEVVNQVEGAHEVVEVEPSWDNEMEPGTSDFADSPPPQLLPGQRKRMTKTATRSEDRLNLLKIMGDNIKLPEMDTNDQLMSAMSKIMSTLPQLQQSQLRHQISNLVHEAQTEYLSKLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCC4</accession>
    <name>A0AAV6UCC4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_025935</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000518">
        <property type="protein sequence ID" value="KAG8181389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCC4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15718">
        <property type="entry name" value="FYVE_WDFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000105">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042234">
        <property type="entry name" value="WDFY1/WDFY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189:SF1">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="289"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="370"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8181389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="414" mass="46781" checksum="0296A6C1195DD411" modified="2024-11-27" version="1">MAAEIKPVPGTSSAQFGNARKPQLISKLEGHQDQINMAVIVPNAEGVISVSDDRTVRVWLKRDTGQYWPSICHYMPSPATCIVYSEETKRLFVGMDNGTISEFVLSEDYNRMNHQRNYLAHQGRVADIVFSLWSEWVLSVGRDKYFQWHCSETGQRLGGFQCNAWCTAVQFDSQSKHVFIGDYSGQVTMLKIEEGGYKPITTLKGHSGSIRCLSWDPDRKLLFSGSFDQSIIVWDIGGQQGTAYELQGHHNKVSSLAFANASKQLISGSEDSSIVVWNMKINRLETPEWADSDYCQRCTKPFFWNIKAMVDQKTIGIRQHHCRRCGKAVCDKCSGNKSKIPIMGYEFDVRVCDECHTVITDEDRVSLATFHDARHSIIHMNLDETRSHLLTVGADKVIKLWDVSSLLQPTEDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDC4</accession>
    <name>A0AAV6UDC4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000461">
        <property type="protein sequence ID" value="KAG8182472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDC4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="11071" checksum="65053E4FB2CE7418" modified="2024-11-27" version="1">MNSSTTSIRTKGAKDIFKKKKTAVCVVVNCWHPHSPQASIDSITGFNTKTGLAKGGGRRGVCLYYNNECKGRRGWFGLMPVNVRSESLFSPQLRNHGERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGB5</accession>
    <name>A0AAV6UGB5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_024616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000443">
        <property type="protein sequence ID" value="KAG8182873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGB5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043753482" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="55"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8182873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="501" mass="55841" checksum="07A16F7B13871276" modified="2024-11-27" version="1">MASIAILCLLLMERFLASDMDSLTEPVLNGLRALERTALQYKRSILPGDMLRSRHKMARFYLFTPESPSGDGQRLDGDDPRGLRHFNPKLETKVIIHGFLDKVKIANWMHEMKDEFLMLDNFNVIVVDWSFGNFIPYTKAAANTEPVGEEIARLLISLIEQYGAKPEKFHLIGHSLGSHVAGYVGERVKGLKRISGLDPATYLFKNVHPKSKLDKRDAEFVDVIHTDGGGIGIKEPVGHVDFYPNGGEIQTGCTASNSLRALLEHGVVEGARNVICSHMRAPYLFTATIIPRPCAMLAYKCADWGDFSRGNCDSCGDECAVMGYHTDTRRDYGNLSKHYLLTEDAPPYCGYEYKITVNRVGARPDNVTSQKFRRQEWSTSDILQVSLYGSGGSADFHIEGENYDGWHRSHVVFSPSFLGDVLGAIIRWSKKPMSRAKGVVDLVASVVRVDPGRPPIASIHVSSLKTHTQWRIAPIVFELCVSPALSRSDNQQGATFRSEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHP2</accession>
    <name>A0AAV6UHP2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000413">
        <property type="protein sequence ID" value="KAG8183599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHP2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35355" checksum="0801822B6ED9E8BA" modified="2024-11-27" version="1">MTVVIFDEDHLVISALITIGMQLLFFVIAATFQFDKVTDFAGGVNFIIIALVTFLLSETYATRQILVTALVCAWGVRLSGFLLFRILRIGRDARFDDRRSNVLRFAVFWTFQALWVFTVSLPVIFINSPKKLLPDVNPVPMTTLDIVGTVMFAIGFFCESLADVQKFRYKNRTKEHWCDKGLWKYSRHPNYFGEILLWWGVFVISCNALRGPEWIAILSPLFTSAILLFLSGIPLLERNADDRYRDIEDYITYKHTTSPLIPLPPSVYADIPKFFRAFLLCEFPLYNYMDPNKGADDVREPPAPVHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJ40</accession>
    <name>A0AAV6UJ40_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_008973</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tektin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000378">
        <property type="protein sequence ID" value="KAG8184287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJ40"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF12">
        <property type="entry name" value="TEKTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8184287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="213" mass="24894" checksum="A4CD682FFE2D21B9" modified="2024-11-27" version="1">MKTRRPPIHPFVSMICRWSSPQEWVEFTRHRLFSARDELRSSAVLRDKINSHLLNGYKDLRHQADTVESLLGQRVNETNDSLYRLRKHLQLVIGDIAEAEKTIQFLKKEILEKEAPLKKVQTRLHMRNERPNVELCEDKAQRGLILESRQLAATIQVLQEQLARAQASLANLQTTRRELEREIAVKENTVTVDKGRVQSVRKRFPAQHKLMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJC3</accession>
    <name>A0AAV6UJC3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_002946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000404">
        <property type="protein sequence ID" value="KAG8183793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJC3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="2">
        <location>
            <begin position="65"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8183793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="224" mass="24417" checksum="0D724016DFDBBC2B" modified="2024-11-27" version="1">MSEETDVSAQNLSLEETDKPAENDKPADELVKSSSVEPFDWNNLKSDTSFSEAARKRVLSLAASNNRSTYRKVEEAIAVIGTGDNGASVPAIVTWILNNYSTLDPSKLKVNVKRAILKGLKGGTLVRAKTSKKAMGVSGSFTFPAQRIKLKAVRLEGKKYVFPILQPVSSASNAGDEKPQVSEPVIKRRLSLDASIVKSSPKRVAKKRSKRVISEISDKTEVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UK56</accession>
    <name>A0AAV6UK56_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Follistatin-related protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_005210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000368">
        <property type="protein sequence ID" value="KAG8184596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UK56"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003884">
        <property type="entry name" value="FacI_MAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00057">
        <property type="entry name" value="FIMAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043675366" description="Follistatin-related protein 5" evidence="8">
        <location>
            <begin position="19"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
            <begin position="75"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="298"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="375"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8184596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="870" mass="95099" checksum="6A5E2B50FEC7532C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKX0</accession>
    <name>A0AAV6UKX0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">glutamyl aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">JTE90_005351</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide.</text>
            <dbReference type="EC" id="3.4.11.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="22">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.7" evidence="6"/>
    <dbReference type="EMBL" id="JAFNEN010000376">
        <property type="protein sequence ID" value="KAG8184333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004230">
        <property type="term" value="F:glutamyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000003">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000006">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000013">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000012">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000016">
        <property type="entry name" value="Glutamyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF276">
        <property type="entry name" value="GLUTAMYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13 22" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="28">
        <location>
            <begin position="177"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="26">
        <location>
            <begin position="397"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="27">
        <location>
            <begin position="698"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="28">
        <location>
            <begin position="1050"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="26">
        <location>
            <begin position="1269"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="27">
        <location>
            <begin position="1563"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="28">
        <location>
            <begin position="1914"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="26">
        <location>
            <begin position="2135"/>
            <end position="2348"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="27">
        <location>
            <begin position="2434"/>
            <end position="2747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="108"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="21">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="23">
        <location>
            <position position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAG8184333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2786" mass="322494" checksum="5D213593E525C0EC" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMU1</accession>
    <name>A0AAV6UMU1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_011078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000353">
        <property type="protein sequence ID" value="KAG8184946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMU1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043764720" evidence="2">
        <location>
            <begin position="25"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8184946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="273" mass="31212" checksum="A351F63C8862ABBF" modified="2024-11-27" version="1">MSLSHKTILLTTCLLLSGSLLVECYMQHHGTDVASILAAGLIAHLLRNHHHHHGGHHHHHSARSHHHHGYAAEPHHHYGYTVRPQVNKLYTTEPQANHGYTAPHEVNHGYTDQPQANHGYTAKPQANHGYTAQQEVNHGYTDQPQVYHEYTAQPQANHGYTAQQEVNHGYTDQPQVYHEYTAQPQVNQGYTPEEQQEPRMAPVYHQLVAPQRYPGTAQSFESQVQQGMLTQSHQNQLQPEVQQLNQYRSQKRNPDYSIHDELQSIADQLNQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UN92</accession>
    <name>A0AAV6UN92_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000343">
        <property type="protein sequence ID" value="KAG8185199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UN92"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="8035" checksum="5ACC2104B825858F" modified="2024-11-27" version="1">MRRRPFPGHPPDRFLAHAHSRFFRIGIPNVLARGVRRTIPKYPDEVCTGTVMADHGRYTLKKGYKTVSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNB3</accession>
    <name>A0AAV6UNB3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000320">
        <property type="protein sequence ID" value="KAG8185932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNB3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="168" mass="19074" checksum="521460FB01B0DC3D" modified="2024-11-27" version="1">MSCSEFRIFAFWHHSLKKAKFCMKITRTVIEESSDLPKNQKHYRINSSGEKEPGFGQGFVLLFWTSGRTSAPALLNPALGVGSPRQRDRPAWGRTWDALNNDQEEQKRGETFSEDLPNKNLSFRACAPATRRPVCDLAPTGGKTCAVIVRKRIKDLKFTRESQEVRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNJ8</accession>
    <name>A0AAV6UNJ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_002036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Msh homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000324">
        <property type="protein sequence ID" value="KAG8185811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNJ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050674">
        <property type="entry name" value="Msh_Homeobox_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338">
        <property type="entry name" value="HOMEOBOX PROTEIN MSX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338:SF0">
        <property type="entry name" value="MUSCLE SEGMENTATION HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="187"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="189"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8185811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="323" mass="35947" checksum="F18DA31801961753" modified="2024-11-27" version="1">MQLSSPNGSSDQGSDTKTTPTEYSRTTTSSPTMSSRYQNNSSSSRSPSKSPEAVVIKSKSNKTFSFSVDSLLSDDSGRRSSSSPELRLDHRNGPARTAQEVSDLLLAKQFSMDRILDQAQKVPARLPHGYLSPGSMDFLPRHGSNMMSWSSQQVGMPWFQVSRSQSPDHKQGELPKLPMKCQLRKHKSNRKPRTPFTTQQLLSLERKFRSKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKEKRLKEAEIEKIRMASRPLSLSGFAYPGFLTAGIPPPAHNGMPVSSRPFLGPIMTPYPFYTSSPSGHHHVGSPIATACPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNP9</accession>
    <name>A0AAV6UNP9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Abasic site processing protein HMCES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Peptidase HMCES</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">SRAP domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_025882</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000343">
        <property type="protein sequence ID" value="KAG8185210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNP9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8185210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="293" mass="33442" checksum="5D33C88665EB4918" modified="2024-11-27" version="1">MCGRTACTLDKNGIQLATCKYSRNNENLQWIQKYDWQNYHPNYNISPSQISPVIVNGSTFSANDTDNLVLTPMRWGLIPSWYRGTLQECPLKNNNCRQEGLLEKPTFKGAAKAGRRCIVLADGFYEWKATDSKHKQPYFIYFPQEEGPDVFTRDPETFNQGGEWKGPQLLTMAGLFDVWKGPQNECIYSYSVITLDSSKSFAKIHERMPAILTGKDEVSMWLDTNRVPTKDAMSLVKPVENLQMHKVPTLVNFSRNNSVDLIKPLQESESKPPLKHTGLTSWLIKIQRNSLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNZ2</accession>
    <name>A0AAV6UNZ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_022360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tektin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000335">
        <property type="protein sequence ID" value="KAG8185428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNZ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF12">
        <property type="entry name" value="TEKTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8185428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="11553" checksum="02913B4C499B53C9" modified="2024-11-27" version="1">MKNERPNVELCEDKAQRGLILESRQLAATIQVLQEQLARAQASLANLQTTRRELEREIAVMENTVTVDKGRVQSVRKRFPAQHKLMGTRNRSNRSKRKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UP09</accession>
    <name>A0AAV6UP09_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000335">
        <property type="protein sequence ID" value="KAG8185443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UP09"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30526" checksum="822349E2DABD0AB2" modified="2024-11-27" version="1">MGSRETAVPDQAGHASGTDLSLFSNARNSYRMTYLQTLVVNVVTEDRVAAVRVLCDSGSQRSYITKKCVKELKLKPVGTEVIQQEVFGGGKTAPASHNTYSILLRSLDASFQFEVSALDQERICSYVPRVRDAAIFNFLEKKGIHLSDYSSEVGENSDIQILLGADVWSKIITSQHYSLNKDLVAVKTRLGWSVIGKSESGYKDSSSILVSLVASTDISRLWDLESLGITESVISSCFSIRFIKVSASSGEMTSWSGFWLLKDFLTKYLFFCYSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPU8</accession>
    <name>A0AAV6UPU8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_007333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000306">
        <property type="protein sequence ID" value="KAG8186312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPU8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="154"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="774"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="951"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="791"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8186312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="970" mass="110098" checksum="AEF283C459062BA6" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPW3</accession>
    <name>A0AAV6UPW3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_008933</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000327">
        <property type="protein sequence ID" value="KAG8185663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPW3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012599">
        <property type="entry name" value="Propeptide_C1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08127">
        <property type="entry name" value="Propeptide_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043809459" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="9">
        <location>
            <begin position="84"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8185663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="335" mass="36915" checksum="50DE9540460F77AD" modified="2024-11-27" version="1">MKLLLLVAAVLAVASAKYHVPRHVHIHPLSQKMIDVVNYMNTTWTAGKNFDGVSLKYIKGLLGVHKDNKKYRLPSIKHVVPNGLPDNFDAREQWPQCPTISQIRDQASCGSCWAFGAVEAISDRHCIHSNGKVNVQISAQDLLTCCDACGDGCNGGFPGAAWTYWVVDGIVTGGLYNSHVGCQPYTIESCEHHTTGKLKPCEGEVDTPQCVNLCETGYNVSYTADKYFGKKSYSIDNDEDQIRTEIYKNGPVEAAFTVFGDFVTYKSGVYRHVTGQELGGHAIRILGWGVEKGTPYWLVANSWNEDWGDKGYFKILRGSNECGIESEIVAGLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPZ5</accession>
    <name>A0AAV6UPZ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_022712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000311">
        <property type="protein sequence ID" value="KAG8186122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPZ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="129"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="439"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8186122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="680" mass="76129" checksum="6F943AB9B309A6BE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ08</accession>
    <name>A0AAV6UQ08_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000297">
        <property type="protein sequence ID" value="KAG8186547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ08"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043731156" evidence="1">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="8966" checksum="3B55C41B5D08D231" modified="2024-11-27" version="1">MQKALVLLFLACLVCVGVSGVEYCGSLPSCGIDQCCTGGFYHRYCRRFAERGEPCERPNSAGSYKTACPCQEGLTCSVIARCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQQ0</accession>
    <name>A0AAV6UQQ0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000309">
        <property type="protein sequence ID" value="KAG8186212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQQ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="18"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="234" mass="27212" checksum="0990C19A8604CE95" modified="2024-11-27" version="1">MSLTECELRNERPERPGEFTFTWSVQNYSYCTKKETECLLSPDFVVAFLGKTKCYLVLYPRGDKQAPGFVSCKFRTYAKDSICNFTLAIRMSNGQFKESDENVYDGSEDFKNGIGYSKFVRFEELKGSDGYLYNDTFTVRCRMWKTSVDIPASVKWEAYSRIKVSKLDYTWILNDISVANGVFENEFNESVDITEFFTNYKEINLQLFEKGSQERNVKFWNPLLLLATSSSKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UT16</accession>
    <name>A0AAV6UT16_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein TSR2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_011711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in 20S pre-rRNA processing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000274">
        <property type="protein sequence ID" value="KAG8187349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UT16"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8187349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="168" mass="19128" checksum="5A53641A97EEE319" modified="2024-11-27" version="1">MDPESTFLTYVRHTLKKWSGFQEAINDGMGGPYSKEKESWIGTEVEKYFKQYSNVKPEEIEDYLGTMIENEFDTYFEDGSLEEVSKNFCTAYPLSLADPNHTIFREMHQKSNSVSTPRANGAAVLRTVSTPLQPEEIACEGIEKLSVNENFEEADGWTFVTKKNKKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTV0</accession>
    <name>A0AAV6UTV0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000267">
        <property type="protein sequence ID" value="KAG8187579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTV0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10103" checksum="1EFDE63F3C3824EF" modified="2024-11-27" version="1">MNRTGRRQYNEIISWDDFLFAFATVSASKSENGTSSGRQSGAKIADKPVMIDHRDIVDVIWWAEDNGSACCISILRSGLLVRVRVITDGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UW04</accession>
    <name>A0AAV6UW04_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000251">
        <property type="protein sequence ID" value="KAG8187997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UW04"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="153" mass="16813" checksum="69F4CE5D303EF319" modified="2024-11-27" version="1">MGRGFEMLGVVFVSIKQKPVKKQVEEMKATLGLICLVGCAIFVAEAQTVSVKLCHEDKDCRSPNLYCHTMAIAGVEISTCRAYLRDGNVCMPNITAKCLPKSECLDFYIRNSTYYKTCQKKTEDTTTSAPVEITTSVDLDTSLGPDDISTVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UW09</accession>
    <name>A0AAV6UW09_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000264">
        <property type="protein sequence ID" value="KAG8187655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UW09"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="104" mass="11762" checksum="F037AB8D02C7272E" modified="2024-11-27" version="1">MTDLRACDPMHAPRNTRSPSLVGKKDGEWWELLGSSGIGKNWYLETTSFEKRSRKRESGHFLMGANHLLLFFDISSSSHLPPFWSTCSSVVCCIGRIYTGDLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UY01</accession>
    <name>A0AAV6UY01_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_005944</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000235">
        <property type="protein sequence ID" value="KAG8188588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UY01"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="18"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="7">
        <location>
            <begin position="422"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8188588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="576" mass="63234" checksum="46C6419F55F0F649" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UY52</accession>
    <name>A0AAV6UY52_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000221">
        <property type="protein sequence ID" value="KAG8189109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UY52"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8078" checksum="D32FFF7CB656920B" modified="2024-11-27" version="1">MRSASATGPVPQATSASSLAPLEYKHRSSAKTKSFTLIPAEEMKKKMGLVDISILGVFLSLSQVEGKLRTVFQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYD1</accession>
    <name>A0AAV6UYD1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000233">
        <property type="protein sequence ID" value="KAG8188679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYD1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="123" mass="14363" checksum="07E6CF6F3EA89C78" modified="2024-11-27" version="1">MYNFFFTPNSNIFSLSNSCPKLPLFNKPSSIHPNTIIKEPKTETFHLYPPGWKFHAGLKLFNRGASLKRTTKAEEYFARPFCATFRRGVTAGAPPSDEFALQFHAYLMFSLWWNWKFFPFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYL1</accession>
    <name>A0AAV6UYL1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_018127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000214">
        <property type="protein sequence ID" value="KAG8189475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYL1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="427"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="852"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1010"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1041"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8189475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1110" mass="125376" checksum="DF4C4CFB1EF39D5F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZL0</accession>
    <name>A0AAV6UZL0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000202">
        <property type="protein sequence ID" value="KAG8189850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZL0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="121" mass="13942" checksum="5323C8167D6CD100" modified="2024-11-27" version="1">MGRTRSIWTSALRLKLPPGHIGPPSRGPGQHLMSLICQASLLRVAWWWFRLDCRERVTLCHSTSKNRVEAHQRQRDISTKEEFRSTSPSHQKSNSFLVSDRPGEEQRHLCGIQPLVLFDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0F3</accession>
    <name>A0AAV6V0F3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000212">
        <property type="protein sequence ID" value="KAG8189563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0F3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="151" mass="17992" checksum="25ECBAA963BE8546" modified="2024-11-27" version="1">MNINSLRRTLKYFRFNGFLRRKNLPMMKEVYVKQKSGFLFVKERDIFDKPYTSSSSDDESTDSSDSDEILCDKKEDSKPLIKSIIKSDKTQDCDKKESENEWDIVSEELEKKLNTEKNTKHASIQRDPPPNEKRARRNWFSRFSLLNYIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0I9</accession>
    <name>A0AAV6V0I9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_026713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:36684"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="JAFNEN010000193">
        <property type="protein sequence ID" value="KAG8190146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0I9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF2">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="99"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="601"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8190146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="639" mass="71890" checksum="4CE48BD9EF3599E6" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0R1</accession>
    <name>A0AAV6V0R1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">UDP-glucose:glycoprotein glucosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_008702</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61304"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:59080"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000192">
        <property type="protein sequence ID" value="KAG8190169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000004">
        <property type="entry name" value="UDP-glucose glycoprotein glucosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="14">
        <location>
            <begin position="270"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="15">
        <location>
            <begin position="409"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="16">
        <location>
            <begin position="668"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="17">
        <location>
            <begin position="1201"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1471"/>
            <end position="1494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8190169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1494" mass="170116" checksum="36AE0D46EDF338F8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0S4</accession>
    <name>A0AAV6V0S4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000191">
        <property type="protein sequence ID" value="KAG8190236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0S4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13514" checksum="9F72201F3E9B9830" modified="2024-11-27" version="1">MEPMGQAKRWCPKSKKKIDLPQPGIVGSYNKNMSGVDILDRFFEFLPTKNKGKEIVVTFFYQHSKHVCESCLENPSRDEWTHVAISIFTRYCVVFDEIRETGIVANISTWTTHTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1I9</accession>
    <name>A0AAV6V1I9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000184">
        <property type="protein sequence ID" value="KAG8190424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1I9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7597" checksum="40D422568F049312" modified="2024-11-27" version="1">MLIQADGNVPIWHRSSGGYLSLSTPEVCRLHPSSRGGRADNDPSSASSCIGWLHLWCPEMENRVEKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V343</accession>
    <name>A0AAV6V343_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000191">
        <property type="protein sequence ID" value="KAG8190235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V343"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="2"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="117" mass="13673" checksum="46473FC548A39FCC" modified="2024-11-27" version="1">MYMRNKPIKFGYKLWILASSQGYPFNIQVYVGKEATVTDKIPLGTRVVLDILECVENCRRHILYVDNFFNSLKLLEKNAKKGILSIRNGERELTSEMSFTRYYSFGRKKKEGHLTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7L5</accession>
    <name>A0AAV6V7L5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000136">
        <property type="protein sequence ID" value="KAG8192685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7L5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="10136" checksum="AB5D1A4535827E41" modified="2024-11-27" version="1">MYKTTNLPKFFDIYFLGNSHRGEDLYKMDAKQVDSNSTRRRNTGAAIRIVNVALEDRTAVTSRRAPDWEIARKEKKNIKAERYIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9B2</accession>
    <name>A0AAV6V9B2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA methyltransferase 1-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_009971</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000143">
        <property type="protein sequence ID" value="KAG8192211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9B2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000087">
        <property type="entry name" value="DNA methyltransferase 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008468">
        <property type="entry name" value="DMAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05499">
        <property type="entry name" value="DMAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="10">
        <location>
            <begin position="114"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="DNA methyltransferase 1-associated 1" evidence="9">
        <location>
            <begin position="233"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8192211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="415" mass="48410" checksum="90A423A088A7470F" modified="2024-11-27" version="1">MSDVLDILDVERPHTPEITRESIIGDRKKKKKLSDVPFKRPEGMHRELFALLYSDNKDNAPMFATDDKGYKQNKAKLGLKRVRPWKWMPFTNPARKDAAIFHHWRRIEDEGEEYAFAKFNKAVPIPEFTNDEYLQHLQIEGWTQQETDHLFDLCQRFDLRFIVIQDRWDKSRFASRSVEDLKERYYNICNILAKIHAVGNIEPKLIAYDSEHERKRKEQLIKLYDRTPEQVEEEQTLLNELRKIELRKKEREKKTQDLQKLITAADSSQGETKRLEKKGPKKKVVQQKNIKAESTSVDSAGIKFADFKGSGVTLRSQRMKLPASVGQKKAKAIEQLLKELDIEPNPIPTDDICLHFNELRSDMVLLYELKLALGSCEFELQTLRHQTEAMLPIKKEIIDPAPTVSMVLENGGKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VA90</accession>
    <name>A0AAV6VA90_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000134">
        <property type="protein sequence ID" value="KAG8192879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VA90"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="123" mass="14056" checksum="1794D0FCB001F83E" modified="2024-11-27" version="1">MIVETFPLCPHAAMMICNNYPLAMMNLPIVSVVERATRLLDILGMCGSFNSLCLKDELLKELADMLRNASVDDGFEYLDFPDNEIEMSECLVIQVLMTGKRCQIYEQDKNPKCIQNFINWKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAB8</accession>
    <name>A0AAV6VAB8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_004995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000115">
        <property type="protein sequence ID" value="KAG8193695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAB8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8193695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="106" mass="12589" checksum="654D17E54DBF554F" modified="2024-11-27" version="1">MIFIFSDEYEEEELTCNFCDRSFRSVKRLERHQTRLRHYACSVCDAPFQALSALEAHKEALDHFSDYELRALRHFASTQQDGPDEQDEDLDDDEEDGKPEERRMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBY3</accession>
    <name>A0AAV6VBY3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_002377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000107">
        <property type="protein sequence ID" value="KAG8194172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBY3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118:SF12">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044023379" description="Cyclase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8194172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31244" checksum="AB10FE3DE86D9923" modified="2024-11-27" version="1">MAFLCNLLLVCSLSVARCAPVPLEMIDMTHPFDNSTLGWPTQKKFQIVVKENGTQREGQWVQSEEYAGGSHVGTHLDAPCHFNRRGWCVDDVPFSRLVAPAAVVDVTRRSRDDADYLVRVRDLEGWERETGESLNGTIVLMRSGWGRKWPDKEAFTGTAGNRSSQLHFPGLSKEAAQWLVDKRNIFGLGTETLSLDGGQSRDMSAHRTLLGKNVFGLENVANMEDIPIYGATLHVFPMKIGRASGAPVRIVATYPKMKYAKKEEEYGTEGTLREIIIFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VC10</accession>
    <name>A0AAV6VC10_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hexosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000122">
        <property type="protein sequence ID" value="KAG8193423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VC10"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043876900" description="Hexosyltransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30853" checksum="2B2F578143BC7539" modified="2024-11-27" version="1">MPKRRPLHFALFLLFCGGGGALFLRLRVAPPPAPPPLFLGRNSIPESMCDPAYLAMVVVKGADSSTRQLIRETWGHPFHTHMLGLSVAYGVSVDELADLESAMFGDLLHLQLGRDGPLDLLQAAREACRRPYFLVMLKKDVFVNTFALVDFLKDLQKSPLFLQHRNVIWCHLREADHDVSASNDASGQTHHCLPGAFITVPSAVDAILLTEHSNNISQTMTSVTGALAKEAGVDLVQMEDRLNEKRTIFRHVDKDDKITRDLWKKLIEGRLRKDGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VC77</accession>
    <name>A0AAV6VC77_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_027007</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000126">
        <property type="protein sequence ID" value="KAG8193263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VC77"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF83">
        <property type="entry name" value="INTEGRIN ALPHA-PS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043091875" evidence="13">
        <location>
            <begin position="19"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1017"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="101"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="176"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="239"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="296"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="358"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="419"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="15">
        <location>
            <begin position="466"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="16">
        <location>
            <begin position="624"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="17">
        <location>
            <begin position="792"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1052"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8193263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1074" mass="118527" checksum="296F3B7107673B59" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCJ1</accession>
    <name>A0AAV6VCJ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dual oxidase maturation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_005000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DUOXA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000115">
        <property type="protein sequence ID" value="KAG8193700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCJ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018469">
        <property type="entry name" value="Dual_oxidase_maturation_fac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158">
        <property type="entry name" value="DUAL OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158:SF10">
        <property type="entry name" value="LD27791P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10204">
        <property type="entry name" value="DuoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8193700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44112" checksum="99579E4DD8B14BEA" modified="2024-11-27" version="1">MSSTASLRATPLVMITWEKFISLTYENLSWEFHIKSTTEPCYPFLSSWNVLPKFTTFITVTISLLVGAVILICTFGTEWHVAQASISSPYRAFSREKIFADVAVKIGLSSVNITLQATPVHKRSEDINYNERFQWVGADEMREGYRGALVRGLPFPLLTIAEYFTQELEGFCWGRRYRMAGYYSTILLWCAFSLWLLMNLLLCTVPRYGAYTMQLTGAVLLLTSALYTHLLPKKPLVIPFEGGSLHFRLGWCFWAVLAAGIVSVVVGGAEAVLDLLFPNKFSTILEVDYDMPCRYTRTGYQVPEPPKVPPAPKEGFENNAFEKGEEEEENYSTLVNGKRAVSLRNFGKFAQKEGLGNPFYQAKRMNNFTTNAYKPSTSKDVNIDISAASLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEA8</accession>
    <name>A0AAV6VEA8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ectopic P granules protein 5 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_029615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPG5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000094">
        <property type="protein sequence ID" value="KAG8195034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051436">
        <property type="entry name" value="Autophagy-related_EPG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058750">
        <property type="entry name" value="TPR_Epg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059030">
        <property type="entry name" value="TPR_Epg5_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139:SF4">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26103">
        <property type="entry name" value="TPR_Epg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26573">
        <property type="entry name" value="TPR_Epg5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epg5-like TPR" evidence="6">
        <location>
            <begin position="1169"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="domain" description="Epg5-like central TPR repeats" evidence="5">
        <location>
            <begin position="1632"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8195034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2339" mass="271036" checksum="268ADCB067C99427" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEM1</accession>
    <name>A0AAV6VEM1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide-binding protein-like 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_002368</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000107">
        <property type="protein sequence ID" value="KAG8194161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEM1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000002">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3 (nucleolar)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000493">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="126"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="541"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="541"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8194161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="572" mass="64352" checksum="D36EA005F98D6C84" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VG49</accession>
    <name>A0AAV6VG49_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000087">
        <property type="protein sequence ID" value="KAG8195472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VG49"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="38832" checksum="5B861569DD635AA8" modified="2024-11-27" version="1">MVERFHRSLKQALMCHHTLRWTQALPLVLLGLRSAIKEDLGCTSSELVYGSTIRLPSEIISPSPTTQPLSLPTPHHLQILRLPNPQLCLNQFQSSHRFLQKHLIHHRSVQGTVSHFKQHALDAVYVSTPGHTKMEKSNVVGLSRSKSSQVTSQSKYQAKVASQQSQYVSSASSYGSQQPVYSASVTASGNTSPSQMGYSSLATASYSSNNTGYSNQPNVYSGSTNTTTQGYSSHATASYSSNNTGYSNQQNGCSLSTDTITQGSMLSSQAGAKQCLLPSDFIISPCQAPFPYSLLTTPAYVASVTTSGNTYPLQTDACFEESLESSEDSQDSFSAELQTIFIKKIAEEESVSAQRIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGE7</accession>
    <name>A0AAV6VGE7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000100">
        <property type="protein sequence ID" value="KAG8194703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGE7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="430" mass="48995" checksum="D8E0B49B5889B86A" modified="2024-11-27" version="1">MVALATFAKAGYAGDIGLLILAIIYNYFVAMAEEQNKAEKDLVEVIEPIFFEVISLTQSPMIKHIETIAFDFPKLSKSFLKWHAKRHMKYKAKLAFFNTLDSIAEREYEEIEANLGKSVTDVKGSGDVVAEVNIPNLKIHHSEPENKHKENFGINAEHVEKSGEIVAEENIPNLKNQYEVPKNNEHEQIKANFANIEGSDSVVPEPNFVEVPLQSPTIQKIETIAFDLPKISKSFLKKHAKRHRKYKAKLAFYSTLDSIAETEHKENFGIDAEDVENTGEIVVEENIPNLKMQQDEPESNSQMKANLGINIADFEVRDGDVPEAISVPQVQKVKRFADVIRNGSGKFFQRQVNRYRTHRAKVAFTSTLADTDSEELEPNTDLNVADVNTSNFEVQHSEPEEEHSSIRNKCKKWNSFKKRFSRIKKFFKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHN2</accession>
    <name>A0AAV6VHN2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHN2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043910849" evidence="1">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="78" mass="8911" checksum="8C983D9BCD3E002F" modified="2024-11-27" version="1">MSGVKHSCVALLLLIVAVAVMWRTTEGRYLPTRADNTRYEQIKGLITALLDEADRQNRKERNMEMIFVLITSTTSLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHN5</accession>
    <name>A0AAV6VHN5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_027940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000091">
        <property type="protein sequence ID" value="KAG8195196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHN5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.200:FF:000001">
        <property type="entry name" value="RNA polymerase-associated protein RTF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="10">
        <location>
            <begin position="322"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="188"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="590"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="192"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8195196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="682" mass="78408" checksum="C7836C28B6FB8D5F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHT9</accession>
    <name>A0AAV6VHT9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_028985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000075">
        <property type="protein sequence ID" value="KAG8196015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHT9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="173"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8196015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="362" mass="40955" checksum="D8D62B80250CE4E8" modified="2024-11-27" version="1">MVTLRYLSTGMSFRALAFSFRMGNNTVGAIIKEVIIGYMGRAAAPSHASPYNGKAKGSGRRLPQCVELPPCCRVTRWQTCNVDRAIRIFTDIIMACVIKCIPRGQRKKYAPFWNKELQSLKKHRDEARDRTESTGLMSDCIELRKRQACLRKAIREAKRGTFRDFVEGLDFLLQALVDCNYKFLVIDVGGYGKQSDGGTFLASDLYTAIADGSIVLPQQDDLPDTNVEAPYVMLADEAYPLLPFMMTPFKRATLDDSTRVFNERLSRARKTVECAFGILFSKWRILSKPIETKVETADLIIKCICFLQNVIIDNEGFERHLTDVSINPNSAMLNQPGRLSNEAKAVRQLFTTYFEKFVLSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIY2</accession>
    <name>A0AAV6VIY2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_028980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000075">
        <property type="protein sequence ID" value="KAG8196010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIY2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF141">
        <property type="entry name" value="TRANSPOSASE HELIX-TURN-HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Helix-turn-helix" evidence="4">
        <location>
            <begin position="78"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="159"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8196010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37893" checksum="7DB27213A69DAF84" modified="2024-11-27" version="1">MKKVAEYEKMVPAMLKKQKALSVVNENLRSQLLAQDEIHQILNSKKLLEFYIGIQNRDAFNVLLDLCQEEWQPSVETHLEPASQLLLVLMRLRLGLLFKDLAHRFKICYSTASLIFSDWMNILYAVGQTFVMWCTKKSIRRNLPAAFQNPTFKKVRGLIDCTEVFIERPTSLNARAQTYSSYKGHNTVKFLVVTTPAGGISFVSKAWGGRASDKEITANCGLLDLVEPGDVYLVDRGFNCEELFATKGCSLLIPAFTKGKSQLSGEEVIRSRQYSNVRIHVERRIGKLKNYRILSRTLPISVLKHRSDEDICILDKILVVCSALSNLQVSIMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJ57</accession>
    <name>A0AAV6VJ57_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat flightless-interacting protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_014158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LRRFIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000067">
        <property type="protein sequence ID" value="KAG8196597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJ57"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019139">
        <property type="entry name" value="LRRFIP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19212:SF0">
        <property type="entry name" value="LD07988P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19212">
        <property type="entry name" value="LEUCINE RICH REPEAT IN FLII INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09738">
        <property type="entry name" value="LRRFIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="115"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="324"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8196597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="48996" checksum="CE521441D759A9E2" modified="2024-11-27" version="1">MSSPRVRRRGIQRLYSAEDEVLDKVVQEAEARLVARRQARAEARDIRIREIEKQKEAEDHTDGQYDDHLTVEPSRPPRGIRSEAKEHAPPYASVGSCDSRRSSEDFPETIGSKEYKLLTNQVMELEEKFRKAMITTAQLDNEKTSLSYQVDTLKDELQEIEELYLSVQKDYKNVSRAHDLMSRDFKDLTRQNELLKDCIKFRDELIAERGLVLVGGEEEEVDEEEDESADNSEHKKKPESERQKRIAKMALVSQEGADILKHAGSGTLDVRLKKLAEEKQDLLDEIYRMRLDLEEERQKAYKLDQMSLMRSGANGPEIKLMEVQREANKQVNDYKYRLKRADQEITTLQGCVTRIEGQLARFKTQAESSEQVEDELRTEKRKLQREFREAQSRIEELETANVHLQKRIDKLKTVKSVLIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJB3</accession>
    <name>A0AAV6VJB3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cell division cycle 5-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_007866</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJB3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="16">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="15">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="15">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="16">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="216"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="676"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8196130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="803" mass="91664" checksum="B7A5C3FC7FE50E1D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJM4</accession>
    <name>A0AAV6VJM4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_013818</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000072">
        <property type="protein sequence ID" value="KAG8196333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJM4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12109">
        <property type="entry name" value="Hr_FBXL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045808">
        <property type="entry name" value="Hr_FBXL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF19">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="194"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8196333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="592" mass="66808" checksum="D45D493331CDE80B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJW5</accession>
    <name>A0AAV6VJW5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000062">
        <property type="protein sequence ID" value="KAG8196964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJW5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="205" mass="22933" checksum="202DFDA7951C9DBC" modified="2024-11-27" version="1">MSEEVRVTLEEVGHYDLDADDEDDSLEDHHASNLDLEGSIVVGGTHRRRGSSHRRHDSAHKCRDPSHKYRDSASRRDDSGDANQSEHDPSYEWQDSSHKCCDPAHKCCDSASCSGSSSSRRSSCCSCSSSSSSSRGYSRSGSSAIDDDSQRQDDEIDLPYPGFRPVTMFCLTQTSRPRNLCLRIVTNPYPFICYKCALYLSHLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKR6</accession>
    <name>A0AAV6VKR6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proton-coupled folate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_011324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000058">
        <property type="protein sequence ID" value="KAG8197164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKR6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8197164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="60652" checksum="A7F23570156CBB57" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKV8</accession>
    <name>A0AAV6VKV8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000068">
        <property type="protein sequence ID" value="KAG8196532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKV8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9737" checksum="5D2E04BB3134476E" modified="2024-11-27" version="1">MATPPSQSCLASGIPEDRFWDPEKMLHHRFLLKTSHCAFFIPRAFIRTRSAIQTLFICEGEGLFFIYRVTQLHYRHKLGNGQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLT9</accession>
    <name>A0AAV6VLT9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_027595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLT9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8196884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="113" mass="13167" checksum="FFCF45BC22B62699" modified="2024-11-27" version="1">MAGVDTILSRLTRNTARATLKCSKCHFEFIPYNTFLAGSPPMQTIGVYRCKTCSKEFAKKYNFLRHLEKHKEVRQVFSCEICGATKTRKDHLKTHLFYVHNINPSKKTQWNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VN87</accession>
    <name>A0AAV6VN87_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000058">
        <property type="protein sequence ID" value="KAG8197178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VN87"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="742" mass="81659" checksum="E92805A55C42F20E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP01</accession>
    <name>A0AAV6VP01_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_021528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP01"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF235">
        <property type="entry name" value="CUTICULAR PROTEIN 73D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043350005" description="Cuticular protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8198274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="31937" checksum="028317B93A7C6AB1" modified="2024-11-27" version="1">MIFTQVLFAVAAVTTAYATGMEGGGMMGGGGMGGKMGGIGGYGGGMGGGGMMGGGGMMGGGSMMGGGGMMGGGGMGGKMGGIGGYGGGMGGGGMMGGGGTGGKMGGLGGYGGGMGGHGMGGGMGMFMPKPYGFGYNANGYGGNHYRQEQGDGSGTVKGSYGYTDMQGLYRKVNYIADKDGFKAQVMTNEPGTLDHKMENPAHVDLMAQPSPPGVQEKYTQFGGHGMGGGMGGGIKGGMGGMGGMGGGMGGGIKGGMGGMGGMIGIGGGMKGGMAGMGGMGKGMRSGIMGGMGGGMYGGMGSGMHGGMGGGMKSGMGMSMMGGMGGMGGGMKGGMGGSGMHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPN6</accession>
    <name>A0AAV6VPN6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="15">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_007225</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum membrane</location>
            <topology evidence="15">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="15"/>
    <dbReference type="EMBL" id="JAFNEN010000054">
        <property type="protein sequence ID" value="KAG8197486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPN6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12160:FF:000005">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000002">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918">
        <property type="entry name" value="RADICAL SAM PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918:SF45">
        <property type="entry name" value="THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="17">
        <location>
            <begin position="101"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="237"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="16">
        <location>
            <begin position="468"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8197486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="563" mass="63387" checksum="4E72BE12097B0180" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQ33</accession>
    <name>A0AAV6VQ33_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000046">
        <property type="protein sequence ID" value="KAG8197994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQ33"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12188" checksum="64174C70C02E6BC6" modified="2024-11-27" version="1">MLGLFLAHHIMQLQQYLFPPYSNGGFYAHHKADSLTYPVGYMMHPQQHPSPMQQGMEQMQGGMHPPPGAMQGPPGGLQGPLAYLERTMSSIGNVCKNMPNSERVDNFVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VR10</accession>
    <name>A0AAV6VR10_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_017369</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000039">
        <property type="protein sequence ID" value="KAG8198503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VR10"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000011">
        <property type="entry name" value="Prolyl alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043922006" description="procollagen-proline 4-dioxygenase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="359"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8198503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="491" mass="55146" checksum="18965867BEE0B34B" modified="2024-11-27" version="1">MIVLPFVFLCVFAVRGELYSALAGMETLLDTQRVIIHTMDEHIQSMERRLGTLKKCGRVGALKACIKFPIEQKQNFSELTTFHSVVLPDENDLDGAAKALLRVQQTYGLKTSELAEGKIFGVTRVLSLTEGDCFELGRQAYHNGFYESALSWLELAKNMSLANAEDANSMPEIQRYLKAAEMEKDRSDFMVFASNLFQLGLMSMNSLEDPNHTRTMTDVALSKNIFMGQANFFDEATYKQLCQSSMRDVAASPSSVLRCRLVSSHPYLVLQPVKEEELWAEPKIALYHGVISDREMDTMKEMARPQLKRAEVAEYTSSLGHRVSDTRVTKIAWLKRGDHPLIPELYARIESVTGLSSVSAEPFQMANYGLGGHFHLHMDVLPDTETYFGPDMGNRVATWMYYMSDVNGGGATVFPRLNITVWPKKGSALFWHNINSNGIGNILTLHGACPVVSGSKWVTNVWYHERGQEFRLKCGKHPDSALLQTNSFKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTI8</accession>
    <name>A0AAV6VTI8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000032">
        <property type="protein sequence ID" value="KAG8199066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTI8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10438" checksum="145130A055618BEF" modified="2024-11-27" version="1">MIKRTLSREEIHVLAPPQSINIRLSLRGKDYVNIPIFHDGTSVLFFTLCGAPVRQLLKHEEQPDSGAYWLHIDHAAFILLAFFILLLGEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTR0</accession>
    <name>A0AAV6VTR0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">LIM homeobox transcription factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_000286</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTR0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM domain family"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LIM/homeobox protein Lhx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD"/>
    </dbReference>
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        <property type="entry name" value="Homeobox_CS"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
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        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="124"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="126"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="184"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8199418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36979" checksum="5AB262B064463EE2" modified="2024-11-27" version="1">MRLLCPESGTSASQLETKALNTIRCLDYVFKLFAAKCAGCVQPISPTELVMRALDCVYHVACFVCVGCGRQLQKGDQFVLRSGRLYCRPDFEKEMQLMQMVTRGENGQLTGTGHNGQPRQDGRRGPKRPRTILTTAQRRAFKASFEISQKPCRKVRESLAKETGLSVRIVQVWFQNQRAKLKKLQRKQQQQLQQGQKQTDQNGGSNPDLSSPAGKDGKKSDELSHGDPGEYSPAYSRLGDSDPSQFPLAPLSYASHEGQYYSSSHPDAQYMKSDISMDSDNSLGGLEDVLIGQGGTGGPGGDGGHIFPSSVNPIDKLYSMQTSYFSSNECECLGATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VUV3</accession>
    <name>A0AAV6VUV3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 11">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 11">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 11">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_000595</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 11"/>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VUV3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000107">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054608">
        <property type="entry name" value="SYY-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22421">
        <property type="entry name" value="SYY_C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Tyrosine--tRNA ligase SYY-like C-terminal" evidence="12">
        <location>
            <begin position="394"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8200519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="464" mass="52668" checksum="28A8AEB5563FA901" modified="2024-11-27" version="1">MAFCIGKTCRPFISFNYRNWCYKQVRKSSSDLLYGLLRRGLIKQIFPNDQSINCVGTPCAYAGFDATADSLHIGNLLVLIGLVHWQRAGFDTIAVIGDTTAEVGDPSGHKTDRNVLSRNIVQKNADSIEENIFNILKNHESYILPRTKKKSKSLGKLKILRNSEWYQKTSIVDFISQAGRELRIGDMLSRTSVKLRMETGAGINFTEFSYQVFQSYDWLHLCKTYNCRFQFGGNDQLGNIMSGYNLVSGSLYHPVYGAVLPLIQSESGDKFGKSAGNAVWLSPQHTSPYELYQFFLRIQDADVNNYLKLFTFLKPEEIEDLVQRHMKSPDSRKAQKKIAEEVTLLVHGEQGLNLAETATKILFQSSIESLAKLPIKDLNQVFPLSTVSQIFFEPGISIFDLTMKIGCFKTKDDADRIINGGGVYLNFERVSSPQFQIIPEQHILFNKISLIRIGKKNYYIVQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VV68</accession>
    <name>A0AAV6VV68_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytosolic carboxypeptidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_011821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000028">
        <property type="protein sequence ID" value="KAG8199361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VV68"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF9">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosolic carboxypeptidase N-terminal" evidence="3">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8199361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="134" mass="15104" checksum="CE08DEC67B54A9BA" modified="2024-11-27" version="1">MGDFDSESSSSDGENAGEVKNVARLVMRPPGHSGKAKKGHLVFDASFEGGNLGRVDYVGELDYDLYVRPDVANLRHRVWFNFTVENVRADQKPLQCPPRPADDNHFNTILISEILIMNYLNLFILTCFVKLTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWB6</accession>
    <name>A0AAV6VWB6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_019861</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000007">
        <property type="protein sequence ID" value="KAG8201222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VWB6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20193">
        <property type="entry name" value="T-box_TBX20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000008">
        <property type="entry name" value="T-box transcription factor TBX20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002070">
        <property type="entry name" value="TF_Brachyury"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF190">
        <property type="entry name" value="T-BOX TRANSCRIPTION FACTOR TBX20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00938">
        <property type="entry name" value="BRACHYURY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="8">
        <location>
            <begin position="160"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="488"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8201222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="534" mass="59188" checksum="4401906876E6A483" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VX36</accession>
    <name>A0AAV6VX36_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_028806</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000008">
        <property type="protein sequence ID" value="KAG8201142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VX36"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000065">
        <property type="entry name" value="Glutamate-gated chloride channel, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043111055" evidence="11">
        <location>
            <begin position="29"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="43"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="261"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8201142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="419" mass="48086" checksum="53B14F62B8B35045" modified="2024-11-27" version="1">MLRFCDKRKVKVLKVLLVCLALVSEATCSTGTVNSSKLHDLDMLDEVLKNYDRRALPTGPEGTPTVVSCGIFIRSFGSINPSTMDYEVDLYLRQTWYDHRLKQPHLVKPLDLNDPKLVQRIWKPEVFFANAKHAEFQYVTVPNVLVRITPSGEILYMLRLKLRFSCMMDLYRYPMDSQVCTIELESFSKTTDELNLKWTDKEPVMLYDNLKLPQFEIERVNTSLCIEKFHIVNAFFLGEYSCLRAEFYLRRSVGYHLVQSYLPTILIVVISWVSFWLDVNAIPARITLGVTTLLTISSKGAGIQSNLPPVSYVKAMDVWMGACTTFVFAALLEFTLVNYMWRKRPETLPGRSMPIITVKSSKAVMDSEKGDGSQVSSPVQTTARFDTKLHAKRIDKMSRVVFPALFAGFNVVYWLYFMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXC2</accession>
    <name>A0AAV6VXC2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neuronal membrane glycoprotein M6-a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000005">
        <property type="protein sequence ID" value="KAG8201419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXC2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001614">
        <property type="entry name" value="Myelin_PLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683:SF12">
        <property type="entry name" value="M6, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683">
        <property type="entry name" value="MYELIN PROTEOLIPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01275">
        <property type="entry name" value="Myelin_PLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8201419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30555" checksum="EBBF549602BE31A2" modified="2024-11-27" version="1">MFRKAYSYSSVSEQTPSGCCRGPSGCLTRVPFATLIATLLCCTGVGIFLGSFYRGMSLTLRTFEQVFYFQFDWLIDLHIVFIIIGSVMGAFSLILLLVGFLATGATRERVYRGFKSRIGGRVSCAFFMCLTYILELVWLVVFVSLALITFVFSVWWGMCNNLKNEPNPENRCIDLKPLAFLFPNDTDINLLRICDSGKQKNFCKDCVEPSALLFVVSLVASFFVVLSLVHYLMCLSANYARIKDNEKFQELQELAYLQDTELGTLSKDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VYG0</accession>
    <name>A0AAV6VYG0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000004">
        <property type="protein sequence ID" value="KAG8201505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VYG0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051082">
        <property type="entry name" value="Pentapeptide-BTB/POZ_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136:SF17">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="156" mass="18468" checksum="16BF27F95A2620B6" modified="2024-11-27" version="1">MKRMICVHKIRVVFEYADSEKVVFEYADSEKVVFEYADSEKVVFEYADSEKVVFEYADSEKVVFEYADSEKVVFEYADSEKVVFEYADSEKVVFEYADSEKVVFEYADSEKVVFEYADSEKVVFEYADSEKVVFEYADSEKVVFEYADYEKVVFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W3K2</accession>
    <name>A0AAV6W3K2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W3K2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8202055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="386" mass="39320" checksum="9571FCF08B66833B" modified="2024-11-27" version="1">MENRLVTNTKPIVRNPRMEAKLKTTCHEGCCTPYSVSTPLGHEGCSTPYSVGTPLGHEGFNTPYSVCTPLGHEGCSTPYSVGTPLGHEGCSTPYSVSTPLGYEGCSTPCSVSTPQGHEGCSTPYSLSTPLGHEGCSTPHSVSTPLGYEGCNTPYSVSTPLGHEGCSTPCSVSTPLGYEGCSTPYSVGTPLGHEACSTPYSVGTPLGHEGCSTPYSVSTPLGYEGCSTPCSVSTPQGHEGCSTPYSLSTPLGHEGCSTPYSVSTPLGYEGCSTPYSVGTPLGHEACSTPYSVSTPLGHGGCNTPYSVSTPLGHEGCSTPYSVGTPLGHEGCSTPYSVSTPLGYEGCSTPCSVSTPLGYEGCSTPCSVSTPQGHEGCSTPYSLSTPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEC0</accession>
    <name>A0AAV6TEC0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulator of rDNA transcription protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006333">
        <property type="protein sequence ID" value="KAG8156089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEC0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8156089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12748" checksum="2AA829196F371EA5" modified="2024-11-27" version="1">MIGRADIEGSKSNVAMNAWLPRASYPCGNSSDTSCIKLVKSKGSIGPAFAVRIHTENQDQASFCPFALREVSVLAELALGHLRYHLTDVPPQPNNHLNLSSERIARYKEAARLGLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEL2</accession>
    <name>A0AAV6TEL2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005840">
        <property type="protein sequence ID" value="KAG8160094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEL2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8160094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="236" mass="26588" checksum="798F14F63D278C3F" modified="2024-11-27" version="1">MPRQDLNPTSPRPHSQSLSRSYGSNFPTSLTYIVLGQQRRTGHRKRRGAFTRSSVPISGRADSRDTNSYKEKDNSSRVLRRRLRVRLRYRTWSRRTYLRVRVGEILTPFPFGRQRDKHEHVFAFRQTSRFGTDFSDPLGPTDPCSTAVHMEPFSSFSPQGSHLSIWATYHQDLHRWRLQAGSRPAPSTHATGDPPTHCGVNLHEGSSAVAARYRPNAGASSISGLVASVGELLHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TEY6</accession>
    <name>A0AAV6TEY6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005865">
        <property type="protein sequence ID" value="KAG8159486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TEY6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8159486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="10707" checksum="B76A9DAECA89ABE8" modified="2024-11-27" version="1">MADQPGILFDSLCFTFQKSLSTIEGPPPSKGPCDLILPQNIAINKIRKTSHSLSADGSRLTTSRAAYCSGLGKQQGRKGRHRVELATRTAFNSPHPGAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGT4</accession>
    <name>A0AAV6TGT4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004621">
        <property type="protein sequence ID" value="KAG8170972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGT4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="226" mass="24445" checksum="583D72ACCD5B7E6A" modified="2024-11-27" version="1">MYFAHCLGPSNETSVRTCVSPRTEQDYYATTSSGQQRRTGHRKRRCAFTRTASLSPDEPIPGNTNSYKEKITLPGSSVDVSEFGCVTALGPEGPISVSGLGNINPIPFRSQRDKHEHVFAFRQTSRFGTDFSDPLGPTDPCFNCCSHGTLLQLQSSRLSLEYLLLPPRSAPVAAPGGLTPGTFNARHRDPPTHCGVNLHEGSSAVAARYRPNAGASSIFRASCFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6THS5</accession>
    <name>A0AAV6THS5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004557">
        <property type="protein sequence ID" value="KAG8171020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6THS5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9531" checksum="3C77655EA37923E6" modified="2024-11-27" version="1">MRIHSRSHSRLYAMPRELFLIEAFIHFAAKDIAGPGILKKCKRNANARQGAYSMAASAKARQEAFEKETRAAEVATDRAPNTQQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJB9</accession>
    <name>A0AAV6TJB9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003855">
        <property type="protein sequence ID" value="KAG8171545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJB9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24989" checksum="EC99C8E6FC057359" modified="2024-11-27" version="1">MHGRNLFLNGKDFINSVKLKFNALPARSRCARGRPEKDRLCRAGCHRNEDFAHILQVCKPTQGMRIKRHDAIINYAARGLEQRGYIFYHEPHYGTCQGLRKPDLVATRDGKAFVIDAQIVSDGERLSKAHRRKLDKYADLTPIISAQLGVGVVELHSVTLNWRGVWSSDSANALLASGLIRRGYISVISSRCVIGGVAIFNCFSRSTARSRNFRWNRRAGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJY1</accession>
    <name>A0AAV6TJY1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003152">
        <property type="protein sequence ID" value="KAG8172075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJY1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9726" checksum="25708C0087D64FBA" modified="2024-11-27" version="1">MVGVADLDKVVYKEQLFRRELTWAFGLEAGGTPKKKEDRPEDLCPGRPEDLCPPEDYGTPCRLGHIYPPSGSTWRSYLQDCRNIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJZ3</accession>
    <name>A0AAV6TJZ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002920">
        <property type="protein sequence ID" value="KAG8172260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJZ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="217" mass="23287" checksum="3F79E78420BEA886" modified="2024-11-27" version="1">MIAGRPGGGRILQVSPYQLSMLGYAPPNMVVTGDGESGLIPEESLRKTGYPHPGRAAGRQITHSRNGEVVDEKKRRDSLSPVIGMKYTLKPLAIINWRASKVPAAALTLAPIAGGRNESKGHGGGSGPHSGIPVSLAGGAHRENRRVPLWKWRSLSAHVGPKRWELCPDRTRQRKTLVESVAFDVQNRSSRSGSSGVRQSKLELVPSGSFLRIAGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKA7</accession>
    <name>A0AAV6TKA7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003222">
        <property type="protein sequence ID" value="KAG8172038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKA7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="114" mass="12418" checksum="0DF7BBC73A0ECA40" modified="2024-11-27" version="1">MCRITNYSKYVGDILDVLFNPEVLGNSVIRGIKGTQKSVLDPKIINDVQQHVAAKFSISIQLLASVSSTTASNSSHKDNETSLDPASTIPTLSFGATRKDFPSKCNFSMDLFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKU4</accession>
    <name>A0AAV6TKU4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002983">
        <property type="protein sequence ID" value="KAG8172199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKU4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="9009" checksum="B7C95383351BEDFD" modified="2024-11-27" version="1">MTNIIGLFSVVLITSNILDKICSHDAIFHQVFLLRRLMQGDRSHPKTILANNFRPPQSLHNRSVRTNVFNHDIGVSSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TL11</accession>
    <name>A0AAV6TL11_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002587">
        <property type="protein sequence ID" value="KAG8172564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TL11"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="12365" checksum="8956D7C712AEBF28" modified="2024-11-27" version="1" fragment="single">IDEIDKRDREREREREREREREREREREERERDERARERERERERESERERARESEREREREREIERERDRARERDRARERDRARERDLKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMH9</accession>
    <name>A0AAV6TMH9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002290">
        <property type="protein sequence ID" value="KAG8172873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMH9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12239" checksum="884A6FBC77E96304" modified="2024-11-27" version="1">MCASQWVLNKPGGEMKVQAGGGRPHSGSPFPRGRAHRRPAAFHLWKWRSLSAHVGTRKMVNYARTGRGQRKLWWRSVAVLTCKSIVRSGSSGVRLIEPSSSWFPPKFPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNW6</accession>
    <name>A0AAV6TNW6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate/glutamate/uridylate kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_006264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001661">
        <property type="protein sequence ID" value="KAG8173545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNW6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8173545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="221" mass="24039" checksum="21D2002F6F6E7D98" modified="2024-11-27" version="1">MLGMDSKFVNDTRLTDKDTMKIIEMALCGSVNKKIVQHINSVGGLAIGLCGKDGNLIKAEKITATLREDRSNNIEKILDMGFIGRPTEINPDILFFIEESDFIPVIAPIGHGKNGETYHIDADSTASAIAIAVSASKMITFSDTGEEIDKIGGRKISVKNLNASIDCGKIQGEKFIQRLMAYTKMVEECAGVVHIFDGRIPNIMLDLFTENNSSISIVGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQK2</accession>
    <name>A0AAV6TQK2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_023419</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001297">
        <property type="protein sequence ID" value="KAG8174169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQK2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="69"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8174169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="579" mass="65613" checksum="5CFE10742E494C53" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRN0</accession>
    <name>A0AAV6TRN0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_020768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001262">
        <property type="protein sequence ID" value="KAG8174281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRN0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8174281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="523" mass="59248" checksum="3BDD94A3A0B9D05A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TS05</accession>
    <name>A0AAV6TS05_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001241">
        <property type="protein sequence ID" value="KAG8174358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TS05"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8309" checksum="939B339254F21AF9" modified="2024-11-27" version="1">MYCRLEFHSVSSLKWNRLEFFRTPSGVLPCRAHPRKPSHFFSPALHEFYASAGLDILWVGAAPFSRNQDAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSG0</accession>
    <name>A0AAV6TSG0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001118">
        <property type="protein sequence ID" value="KAG8174889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSG0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="166" mass="19273" checksum="42606D2B54FEA6BB" modified="2024-11-27" version="1">MLVLSFSSSFPCNLFSAMECPSPIPALVPYTHIDYVLVVHFIEEEARVVHVMQTDANQREYVVTTTSTLMRNGLGNDGEPPAFTYCVPPSHWMQFLGQYFFPVLLGPKKWFGTHCRATYQFLHRIVPQQAVWMEFQLASHFSSHLHILTMYCRVRKDRELQHSYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUA6</accession>
    <name>A0AAV6TUA6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022621</name>
        <name evidence="1" type="ORF">JTE90_026412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004537">
        <property type="protein sequence ID" value="KAG8171044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010001048">
        <property type="protein sequence ID" value="KAG8175198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUA6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="306" mass="35556" checksum="6233EB1D29205689" modified="2024-11-27" version="1">MNSLQDLLHFILRHDNVVVFGNLGRNPQVVYKMLHADPHLQVVVQSQFYFSGSSPDNRIRMVTHGDIPPDPIDLFVVLEPEPYKLLQKPHQAVRWVVFTSHLTFKSRPETVWTHVCYFHSFNLTEMCRNTQRLLQLQDTSFQTANVNDVRVNAVNTVVVPRQKDTALSEPNTFVIVDLTQYTHPFTMSLAFWDSFDYMLKHVDFIQGWRICFPLKFGRAAFEQFIQTCLDTLFCKRFEHGNVTSLNHILTLLPYYKSGCIDQTFNVPKRRFLGAEIIAPINPDDICKAATMHNLEHWAGNVYRIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUG0</accession>
    <name>A0AAV6TUG0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000962">
        <property type="protein sequence ID" value="KAG8175695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUG0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="145" mass="15817" checksum="D035CB73C6B284BF" modified="2024-11-27" version="1">MPTSMQTILAAVSDLNVDKTAEIADRILEVTPTPTTIFSVSGTNSSFEERLSGEINKLNKRVDLINWHLAKVDLRFAGTGFEPADEVCPITGIFVGTSADLVVSAGKRNVFHHVHIRETPTAESRGGIFFAQWHFPSPVRAGPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVP5</accession>
    <name>A0AAV6TVP5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000948">
        <property type="protein sequence ID" value="KAG8175823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVP5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="57779" checksum="C95CEFE1875BA5FC" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TW05</accession>
    <name>A0AAV6TW05_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_022450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000900">
        <property type="protein sequence ID" value="KAG8176277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TW05"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043787069" evidence="2">
        <location>
            <begin position="26"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="265" mass="29092" checksum="8734622358868D7C" modified="2024-11-27" version="1">MAFVRAHLICLGLLVYVVAVINADGDHHFRITHEPVRRTFRITSAPTIHRHTQKIPGTRTKNVHRHVHEHPGSVALDGADDSYTDSGEAPPIPVPTPGPETSAPDTPAPETPTPETPAPETTAPATGAPATPAPATPAPGHNITHSYRYKIPGNRTTHHHRVKIPGSGRPKQVPSKDTPDAAPGVYYLINLIYNYFSVGGKLTGVPPVDLLLLRYYVAQGPKKFCKYQRIGTTDKLTFESFRWRSLGIDKDRFNVLFCKTKKVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWD6</accession>
    <name>A0AAV6TWD6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000939">
        <property type="protein sequence ID" value="KAG8175918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWD6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22212">
        <property type="entry name" value="CPV_RdRP_pol_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="543" mass="62995" checksum="18AD12B97C6CD4E0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2I4</accession>
    <name>A0AAV6U2I4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_024839</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000674">
        <property type="protein sequence ID" value="KAG8178717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2I4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8178717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="221" mass="23846" checksum="F47F308FF45796BF" modified="2024-11-27" version="1">MNSVMNMCDDAALDFTGEVKTGTTIMAVEFDGGVVIGADSRTTQGAFIPNRVTDKLSRLADHIYALRSGSAADTKAIGAIVAYRLNMLQMELGEPVPVKIAANDVKQIIYNYRESLSASMIVGGWDRKLGGQVYCVPMGGSITREPCCIGGSGSGYIYGFMDENYKPGMDKESCISLVVKAISQAMWRDGSSGGIIRLGIITEKGVERRMLVGDEVPKYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2U4</accession>
    <name>A0AAV6U2U4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP complex mu/sigma subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_029449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000714">
        <property type="protein sequence ID" value="KAG8178143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2U4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14834">
        <property type="entry name" value="AP3_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027155">
        <property type="entry name" value="APS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8178143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="190" mass="21794" checksum="D7F3256501BEC2AA" modified="2024-11-27" version="1">MIKAILVFNNHGKPRLSKFYQFYPEDMQQQIIRETFQLVSKRDDNVCNFLEGGSLIGGSDFKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHYILNELVMGGMVLETNMSEIITRIEEQNKLEKQEAGLSAAPARAVSAMKNMNIPQQIKDMKLPDLPSISTLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3L6</accession>
    <name>A0AAV6U3L6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000674">
        <property type="protein sequence ID" value="KAG8178709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3L6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22955:SF77">
        <property type="entry name" value="ASPARTIC PUTATIVE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22955">
        <property type="entry name" value="RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="166" mass="18764" checksum="7A2331E1DAB0F174" modified="2024-11-27" version="1">MTKIRSCLRCEMNGVMLHTDSTIALAWLKTPANRLKTFIGNRVSKVQRLTEGCQWCHVPSTLNPADIISRGLEPASLPNSYLWWNGPPFIIEGKLSSGTPELPVETDSEYSRELKPSYKRIVTLAIPSIGKKYSDYKKRQQYGTLNKSWTNTGQSHCLTLDKTVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U496</accession>
    <name>A0AAV6U496_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000649">
        <property type="protein sequence ID" value="KAG8179100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U496"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="18116" checksum="31DF9AC2CE0D3195" modified="2024-11-27" version="1">MFLMALRRFVARRGRCTTIYCDNGTNFVGAANCLRLLDWNKVIKHGAINNIHWKFNPPTAAWWGGWWERLIRVMKDLLKRVLGRALLSQEEMFTVLCDCESLMNSRPLTYISENNKDPVPLSPSMFLQDIQEWRTPDLDSVDQKSLNRRNLKVGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4E4</accession>
    <name>A0AAV6U4E4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_016513</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="JAFNEN010000664">
        <property type="protein sequence ID" value="KAG8178843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4E4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8178843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="538" mass="60135" checksum="EC34A45D675F49B3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5A3</accession>
    <name>A0AAV6U5A3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_015364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000665">
        <property type="protein sequence ID" value="KAG8178811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5A3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="8">
        <location>
            <begin position="216"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="9">
        <location>
            <begin position="434"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8178811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="502" mass="57775" checksum="194BE203FE959913" modified="2024-11-27" version="1">MSSKSPRSAKKRPSSRKSLRTKEDIVCAPIKATLESSENFEDYQPSAGLFEEEKDVGGNDVFQVTPLKPKKLLKDPVSTGKLINKLSSVTLASPKMKTPQVETPKEKQGYSLRQRMKRELANLQVSNMESDPEDSDEYNSNDEDSENDNHNIADPVTPKKSKDKSSRSFPETYFFAQKQKKAATSNRTLANLKLEQTDIEQLRNIMTSASEYHKKEKENLYKQYKSQFEKWQFLLHEGFNVLLYGVGSKQKILNSFCKECLGKALHVVIHGFFPSLTIKQVLNSITEDALEYEGKFSSIYDHAEYIKNYFQEGKEELYLIFHNIDGMPLRNVKTQTLLSVLASIPNIHFVCSVDHINSPLIWDQIMLSHFKWVWFDVTTFEPYILETSYENSIFKDQSSHLLLSSLLHVYRSLTPNGQGVFMILANHQKEEKSQTFSGITFHEWYQECREAFLVNSEITMQAQLSEFKNHKLLTSRKSIEGTEVWYIPVDGATLEQFLESCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8C7</accession>
    <name>A0AAV6U8C7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000575">
        <property type="protein sequence ID" value="KAG8180220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8C7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="171" mass="19634" checksum="528E16C85BD0B450" modified="2024-11-27" version="1">MSRKRSSIKKGSNVKEEGSMKKASHVKKKGSVKWASFFKEKRKQKETEVLHWFFRVKEKEELKSLRLVPKSTKSHGPSAFRQNRARSTRTKCLCGTEMFPIGPCPNNVKIKESDKLQSSRNVENLLFSQLPVKTSCFQSLQNGAFCFQDFQFQASLIRNPLQSFALPKFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8I3</accession>
    <name>A0AAV6U8I3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Actin-like protein 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_026641</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000561">
        <property type="protein sequence ID" value="KAG8180479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8I3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000009">
        <property type="entry name" value="Actin-like 6A, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000375">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8180479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="47541" checksum="A0D788C20AE05586" modified="2024-11-27" version="1">MSGGVYGGDEVGALVFDFGHCTIRAGYAGEDTPKADIPTMAGMIEENISDAMEVNGNNATSESSTQKKYFIDTCNIQVPRKGMEMTSFLKDGMIEDWDIFEQVLDYIYSKHIKSEPHLHPVLMSECSWNARSKREKLTELMFEKYNIPAFFLSKNAVLSAFANGRSTGIVVDSGASQTSAVPVHDGYVLSQAIVKSPLAGDFISMQCKQYLEENHVELVPSYLIGSKEVVKENTPAKWVKKSNLPEVTKSWHNYQVKEVLKDFQASVLQVYETQVEKEVVENLPMVHYEFPNGYNQDFGAERFQIPEALFDPTNIKGITGTTIGAAQVVTTSVGMCDIDVRPSLYGGVILAGGNTLIQGFTERLNRDLSAKTPPSMRLKVISSNNNAERRFGAWIGGSILASLGTFQQMWITKQEYDEGGKTQVERKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9L2</accession>
    <name>A0AAV6U9L2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000542">
        <property type="protein sequence ID" value="KAG8180899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9L2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="10828" checksum="8084AD2D453B6DDE" modified="2024-11-27" version="1">MDCHCPLSVLRGRQQCCSCASREPRSLANAHAAVRIAVAPPPPPPPFSRTRSVFSHLQRRNVKPRVVLVLKTSELANRDITKRITSTQLIFKVKDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9M0</accession>
    <name>A0AAV6U9M0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_007481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000560">
        <property type="protein sequence ID" value="KAG8180528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9M0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="352"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8180528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1088" mass="122221" checksum="838CF886FB0155DA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UA95</accession>
    <name>A0AAV6UA95_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000559">
        <property type="protein sequence ID" value="KAG8180551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UA95"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="213" mass="24816" checksum="6C11AAF90C415B40" modified="2024-11-27" version="1">MVNYPKEMKSKLRKMTGVATDPMDLIDIYEGEPSITGEEEAIIMALKGKTMFWKSTTILEDFCEQMRNSNMRLQQAQELIGSLKRILRRVIGNACLQAEELSTVLCEAESLINSRPMTYISEDVDDLKVLSPSMFLNEIEEFGVADFEEIDVKRMNSRFAYRLRLRKRFRRSFRRRSLYANLLFILLTPHHGEDGGLNFHWIFFIVNSSTLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCX8</accession>
    <name>A0AAV6UCX8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_013989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000483">
        <property type="protein sequence ID" value="KAG8182059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCX8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015889">
        <property type="term" value="P:cobalamin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002157">
        <property type="entry name" value="Cbl-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051588">
        <property type="entry name" value="Cobalamin_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559:SF18">
        <property type="entry name" value="TRANSCOBALAMIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559">
        <property type="entry name" value="TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01122">
        <property type="entry name" value="Cobalamin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043989327" evidence="8">
        <location>
            <begin position="16"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="617"/>
            <end position="618"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="398"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8182059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="676" mass="76815" checksum="A6163141662D17BF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UD43</accession>
    <name>A0AAV6UD43_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000477">
        <property type="protein sequence ID" value="KAG8182192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UD43"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="361" mass="40539" checksum="CC103C37E100839C" modified="2024-11-27" version="1">MKRKNVYPGRHLELGGFSIMHPKSSPMVGYWRLVCSNFRVVEDDDDVDDGPSNLDKLWNPLRTIAEEAPSLFSKPPDTSSCRYSTYICCYTPDCTDVNVIRLAAEFIRGRVNYPYVLKYLDTSSLVASERNHLFQHTPEGELYEKLEYGLKLVVATGTLAGSNVLDEFAGLDISTRSKSPDNSHESNEDSESKTLIPSKVFDKDYIFMPSTEEGKAKMWEKKGGKWMVFSPAGFSLDEHDAAWKALVPLCEKGILVGLKASTNVLNKANSQKVRGGFKRTSTAIYCYTADSNNMEDVLQAAVAIREVYNNNYMLFYKLNTQCKGDSFISSYMHTVSGGLYVRDDIKRYELILPKTKCGGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UD98</accession>
    <name>A0AAV6UD98_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_010113</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M67 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000466">
        <property type="protein sequence ID" value="KAG8182347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UD98"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08067">
        <property type="entry name" value="MPN_2A_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000053">
        <property type="entry name" value="MPN domain-containing protein CG4751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040843">
        <property type="entry name" value="RAMA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18755">
        <property type="entry name" value="RAMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="249"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8182347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="491" mass="54955" checksum="FF64AB212C51664A" modified="2024-11-27" version="1">MTTPGSKSDDMMEEEGSAHHSGEEEEEEEGGTGGVDSLEEMQKRRSIQSGRGVTLSMLMSDGILEAGEGFLTIDYLGAKFVGDLLPGGKIRAQETQKIFSSPSSWAIHCKKLLNPDKKSGCGWSSMRYKGKKLDTYKNLWFRKHKQQQQELEKQETIAAQAAAAAAAASSANAKGIHLEHSDDDKKCSSLKKWDLDKMQSMIPRPRPSPQKRVIVPHTVLGNKSFNHDLNTLVKCTPFSGLDRIQPFTVTIATNCLLLVDFHCHIIKNEVVGYLGGNWDIASHNLAVLQAFPCRSGLGDKDSAARVEDEIRRSLERRHLSVVGWYHSHPSFPAQPTIKDIDSQMEYQITMKGDSDSSYTPCLGLICSPYDNQRPALEADYLAYWVMPPPEHRPHEYGRPMQMIYSIAHDSFLTQDLLMEMRLISEYYRSTGEALDFNIDFTNQGSGSCWEKLQSSLRTKLPRDLMVTGAQSSAQAQAVTHFWDFLKGLIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDY2</accession>
    <name>A0AAV6UDY2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Claudin domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_017125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000477">
        <property type="protein sequence ID" value="KAG8182174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDY2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21215">
        <property type="entry name" value="LD36024P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21215:SF0">
        <property type="entry name" value="LD36024P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043708977" description="Claudin domain-containing protein 1" evidence="6">
        <location>
            <begin position="19"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8182174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29183" checksum="BC2E77E067BD2780" modified="2024-11-27" version="1">MACSAVALSVATVAAVIALTCTAIAFGTDNWYEVRVNPDGNERLASLQEFESDLRYYSRDEGIFRICFPDKRPKGVQTYMSPVQTQCLNIDYYINDNGISDSFTDQRWMRLHMARSVVALFIVSFLFSTLSAFPGLVGCWRRSHSNIIATGLLQLLAGLVVASAIGLWHAIPHYEYEKLNFPEMGFNRWPEVLQIYSRSYYGWSYVLAWLGVALTLSSSFMFLCGAQCLKKEKQKEKTQGTAYLVPIYAGPYHCPYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UE93</accession>
    <name>A0AAV6UE93_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_014258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000509">
        <property type="protein sequence ID" value="KAG8181531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UE93"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000085">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000010">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase Pin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="49"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8181531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="160" mass="17941" checksum="4E90F7294C97BEED" modified="2024-11-27" version="1">MSDEELPKGWEKRMSRSTGQAYYLNVYNKESQWDRPTQPAEPGPGCVAVDQVRCSHILVKHKDSRRPSSWREENITRSKEEALDIIEGFREQLMSGTKSFEDLASKYSDCSSAKRGGDLGLFGRGAMQKPFEDASFSLEIGKISEAVHTDSGVHLIVRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFI2</accession>
    <name>A0AAV6UFI2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000460">
        <property type="protein sequence ID" value="KAG8182523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFI2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="18150" checksum="6AB161789CE7C066" modified="2024-11-27" version="1">MVYWIAEAWDEVKSATIIKSWRIIIDTQNTEHHGNSNEGIDELLDLAMQLQLSESINEEDIRDWINADEQQEITDEMIVNKENETSDDDEDSDDKKPNMKISHTDGLKAIESAIEYIEQQEEATPAILLSLKKWRTIAAEKRQNNIKQKTIKDFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFS5</accession>
    <name>A0AAV6UFS5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000444">
        <property type="protein sequence ID" value="KAG8182864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFS5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="9979" checksum="2D0F087C934D7BE5" modified="2024-11-27" version="1">MSATQVLFQANFLDEDVTCASDEQDAKCKWKSPVNIDLKLPSEKGVKGSFILVVIIAHAPVLSQSGCDVEELMVLLENDWVIVLQGIEMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGF4</accession>
    <name>A0AAV6UGF4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_002839</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000416">
        <property type="protein sequence ID" value="KAG8183457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12790">
        <property type="entry name" value="RasGAP_plexin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11236">
        <property type="entry name" value="Sema_plexin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000027">
        <property type="entry name" value="Plexin A, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001407">
        <property type="entry name" value="Plexin A, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000005">
        <property type="entry name" value="Plexin A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000451">
        <property type="entry name" value="Plexin A4, B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000728">
        <property type="entry name" value="Plexin D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046800">
        <property type="entry name" value="Plexin_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041019">
        <property type="entry name" value="TIG1_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041362">
        <property type="entry name" value="TIG2_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF70">
        <property type="entry name" value="PLEXIN A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20170">
        <property type="entry name" value="Plexin_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24479">
        <property type="entry name" value="PSI_PlexinA-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18020">
        <property type="entry name" value="TIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17960">
        <property type="entry name" value="TIG_plexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043574427" description="Sema domain-containing protein" evidence="16">
        <location>
            <begin position="28"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1275"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1391"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="17">
        <location>
            <begin position="23"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8183457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1941" mass="216799" checksum="DEE78EB37079A156" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UH72</accession>
    <name>A0AAV6UH72_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_027481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000437">
        <property type="protein sequence ID" value="KAG8182996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UH72"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8182996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="203" mass="23118" checksum="B14BB6CE3A96BAB5" modified="2024-11-27" version="1">MNSDDTKLSKSLSWLLRHGAAKEGLTFDDGGFIDVDKILKLNQFRDYNESNILKIVAENDKKRFSVRYKNNGDRLQVRANQGHTIPVEEEGLLTLLTDANLPKVIYHGTYFSKLESIKTNGLMRMSRNHIHFVSKFPTESVTSGIRQNSEIVIAVDALQAWKDGYKFYVSENEVVLSPGKEKGAIQAKYITEVWQLNPLKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJ73</accession>
    <name>A0AAV6UJ73_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_007651</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POU transcription factor family. Class-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000383">
        <property type="protein sequence ID" value="KAG8184217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJ73"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002805">
        <property type="term" value="P:regulation of antimicrobial peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000005">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000001">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016362">
        <property type="entry name" value="TF_POU_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF89">
        <property type="entry name" value="POU DOMAIN PROTEIN 2, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002629">
        <property type="entry name" value="Transcription_factor_POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="13">
        <location>
            <begin position="143"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="233"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="235"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8184217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="337" mass="37702" checksum="F2F193EAA86E92AB" modified="2024-11-27" version="1">MKYMPPPSHHHHHNGAGGQQHHWNLPPAHHDAWAPMQDVKPQVQEMHHHRGPTHHQMWHMAGGMGGSPHHQPPSMQQHYSAALNGMMGHPAMRELHENHHPHSHHPLHHEEPPLHHHMEQHHHRGTMQDGDCGGPMGGLGVGEEAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLAKWLEEADSTTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALENHFHKQPKPAAQEIASLADSLQLEKEVVRVWFCNRRQKEKRMTPPMGMGPMDSGPMMGGMGSPMHAHSPTHLMHQSPPPPHSMAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMW1</accession>
    <name>A0AAV6UMW1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000334">
        <property type="protein sequence ID" value="KAG8185489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMW1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="134" mass="15857" checksum="FBC9FDA1D0F2E21E" modified="2024-11-27" version="1">MNKRYRYRQKLKENLRKRFRAEYLGQLKHCAWKRCPTSLQIGQNVLVGNDQTKRLSWPLAKVLELYPGKDGNIRVARLKTAHRELLRTLQRLYPMEMTPDSSDSVQQVSESSQPRSRLVITIKVPSRFQDFELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNF5</accession>
    <name>A0AAV6UNF5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000318">
        <property type="protein sequence ID" value="KAG8185977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNF5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="659" mass="68765" checksum="99EA8BF81B45EB0D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPE2</accession>
    <name>A0AAV6UPE2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_005854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000305">
        <property type="protein sequence ID" value="KAG8186322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPE2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="761"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8186322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="780" mass="87103" checksum="A650A58D11987E8E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQS5</accession>
    <name>A0AAV6UQS5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcitonin receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_020842</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000297">
        <property type="protein sequence ID" value="KAG8186539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQS5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15260">
        <property type="entry name" value="7tmB1_NPR_B4_insect-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF32">
        <property type="entry name" value="DIURETIC HORMONE 31 RECEPTOR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043619339" description="Calcitonin receptor" evidence="12">
        <location>
            <begin position="23"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="13">
        <location>
            <begin position="54"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="13">
        <location>
            <begin position="176"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="269"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8186539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="64344" checksum="9AF58CA99701735F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USE7</accession>
    <name>A0AAV6USE7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000289">
        <property type="protein sequence ID" value="KAG8186768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USE7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="791" mass="89801" checksum="2F8FBFA511B1230A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USP6</accession>
    <name>A0AAV6USP6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000272">
        <property type="protein sequence ID" value="KAG8187417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USP6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="294" mass="33376" checksum="B61AE246DADB1D62" modified="2024-11-27" version="1">MDADIGGPRRWQKNIRSLPGGLAYIYKNGLFTDCQFIVGVKTFKGHSLVLAAKCPLFARMLKMDVEPAKRPAMTCIEIRDMTEDAFEILFNYINTNQIGDMSSQELVLDVYKAAIKYDQPNLKSACEQKILKWELTCDNVISVLQMSDVPLVKNRCWNFIARNVLGVLASVGIREASSDTMATMFERGYLIKKTLTSTELLSNVVSWAEKQLLSDVLEDGKKKKDYTLVREHLMIPCGTTFKSLMSWIGFHKFTPTELGKAISDYPKLLTDEEVRILFQYSFASEGNKPELPNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UT72</accession>
    <name>A0AAV6UT72_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000269">
        <property type="protein sequence ID" value="KAG8187527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UT72"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="95" mass="10398" checksum="29EC3512E8CADEE0" modified="2024-11-27" version="1">MTSKVAISSRPPQPAGESVRAKSSNSDSQFHISLTAPFDFQEHIPTNTMHNGWMLRSSGDNTSWDLEECSVSPVGFAITISKLDKAVTDIKVVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTE8</accession>
    <name>A0AAV6UTE8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000266">
        <property type="protein sequence ID" value="KAG8187602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTE8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="326" mass="35631" checksum="3ADD75A2EA9F216E" modified="2024-11-27" version="1">MDIITNTDTTINMDMITITSMDTTMVTTMLTNMVTTMDIITTTSMVIITDIITGIIMIISMGIIMGTIMVTTMPISMVIIMVITMDTTTITDITMITSMVIIMVITMDTTMPTNTDTIMVTTTVIIMITSTVIIMVTIMDITMPTTTDITMVTTTDIITTTNTDIITVTTTDTTMPTTTDTTMVTTTDTITTTNTDTIMVTTTDTIIIMDTIMDTTTVITMDIIMVTIMDIITDTTMDTTTDTIMDTTTDITMDTTMDIITDIIMVIITAIIMVMATTEEQTSCRRVSMTSMVSLDSISADKRLKIAKSAAPCKKISIPLMGLSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWG8</accession>
    <name>A0AAV6UWG8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_023072</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000232">
        <property type="protein sequence ID" value="KAG8188727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWG8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8188727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="114" mass="13374" checksum="942552BFD16D4B9E" modified="2024-11-27" version="1">MKGFDGQFIRKWLLDNGFEPKVIPQGSKLMSVEVTPLQMRFIDSFNFLPMGLSKLPKTFGKEEITKGYLPPLFNKPENQNYVGELPDAHFYNPDFFSMSSSKRTKFYTWHNERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWJ5</accession>
    <name>A0AAV6UWJ5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000229">
        <property type="protein sequence ID" value="KAG8188850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="14305" checksum="0FDA768ACFF8177A" modified="2024-11-27" version="1">MDSFDTSPPFNNVLHAQYRKNNILPEGGLNHQKKEENSISEWARANGPRSGDFRANKRLGTARGLVWLLKKQKRRKQYSTHSGKSASVPAQRASMKENTPEDLHFSKDKGNVFRYPKSQCLRTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXI6</accession>
    <name>A0AAV6UXI6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHD finger-like domain-containing protein 5A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000219">
        <property type="protein sequence ID" value="KAG8189210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXI6"/>
    <dbReference type="SMR" id="A0AAV6UXI6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12405" checksum="90F7469DE7292BF7" modified="2024-11-27" version="1">MAKHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXR5</accession>
    <name>A0AAV6UXR5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_005981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000235">
        <property type="protein sequence ID" value="KAG8188628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXR5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01259">
        <property type="entry name" value="PH_APBB1IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16138">
        <property type="entry name" value="RA_MRL_MIG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039664">
        <property type="entry name" value="GRB/APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039665">
        <property type="entry name" value="PH_APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243">
        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243:SF23">
        <property type="entry name" value="LD06925P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="189"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="318"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="867"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8188628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="993" mass="109460" checksum="169A98D2A7EB45A5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZB4</accession>
    <name>A0AAV6UZB4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000235">
        <property type="protein sequence ID" value="KAG8188611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZB4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10281" checksum="3C5EFEF1DFC7C419" modified="2024-11-27" version="1">MPRHPQKPDVRRAWKFVARGVLISWSGFRNAPLHRPFVLRMGRLLLCHRHAPLRTNNLEIALPASFRGVMIPGGDSGRGMAGGKWVEMVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V008</accession>
    <name>A0AAV6V008_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pecanex-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_009077</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the pecanex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000199">
        <property type="protein sequence ID" value="KAG8189936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039797">
        <property type="entry name" value="Pecanex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007735">
        <property type="entry name" value="Pecanex_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372">
        <property type="entry name" value="PECANEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372:SF7">
        <property type="entry name" value="PROTEIN PECANEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05041">
        <property type="entry name" value="Pecanex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1068"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1093"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1178"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1226"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1257"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1328"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1353"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1414"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1439"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1470"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1493"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1518"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="domain" description="Pecanex C-terminal" evidence="8">
        <location>
            <begin position="1844"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="546"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="2100"/>
            <end position="2207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="561"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="660"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="816"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2118"/>
            <end position="2174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2176"/>
            <end position="2194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2196"/>
            <end position="2207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8189936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2265" mass="250684" checksum="621B3817D8071FBF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0W0</accession>
    <name>A0AAV6V0W0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000214">
        <property type="protein sequence ID" value="KAG8189491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0W0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10838" checksum="C60A68771518C55C" modified="2024-11-27" version="1">MFPASLSLRAAGKDATNRNQERPLNDYAWRQWLKRNWVHKLYRPEHSKSSHQTTFQDTREPFVNDAEFHIMCSELKSFCAIVLLLAIKKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V110</accession>
    <name>A0AAV6V110_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Solute carrier family 10 member 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_009274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000184">
        <property type="protein sequence ID" value="KAG8190437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V110"/>
    <dbReference type="Proteomes" id="UP000827092">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008508">
        <property type="term" value="F:bile acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8190437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41021" checksum="7602CA1535C9799D" modified="2024-11-27" version="1">MNVSGDSLLADAAAVMVGAEEVLNSSALNETHPVELLDMLPDPVVKLAHDILICVLLISVMFAMGCHITWEEVWSHVRRPVGVLIGMLSQFCLLPLAAFAMIVSLGMDPLYATGMLVLACSPGGVTSNIFSYFCDGDISLSVTMTTCSTIAALGMMPLNMWVYGQWLETGAVVIPYSKMSLSLASVTAPVGAGMLVRWKYPKAAPYITKAGSYAGFAIIFICQTMELIIFPDIFDGIGWQFYVALVLLPFVGLSLGYGLAFCMRQPPPVRKTIAIECSIQNIGTALTVISLSFPLEMQKKVLAFPWLYSLPLIATVTVSCCLYQLYKRTCFKDSSLAGSCEKKLNGLGVPVSVVEKCPCESNPEEMQSFISPQEKLTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V256</accession>
    <name>A0AAV6V256_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_010297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000172">
        <property type="protein sequence ID" value="KAG8190872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V256"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043574432" evidence="2">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8190872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="237" mass="27645" checksum="46203626B3A72F9B" modified="2024-11-27" version="1">MASILLVIFLMIFALTLTGKAEKYGNSGRYTVSSVDEAPSKKHFFNCDKQLEEDEYENRMAEIYECLKSFDNNDKLEEMTKKCYPRLAFPTKWQDATKWYCRKSLAIITKSIECERKFFSCMNKEEATVLKEGIKLCHLKNKERVETDCEYEVNNVQEEDSGEEKDSDEEDSDEEDSDEEDSDEEEDSSEEESDEEEDSSEEDSDEEEDSDEDRMDSDEEDGDDEEDGDEEDNEKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2M2</accession>
    <name>A0AAV6V2M2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000187">
        <property type="protein sequence ID" value="KAG8190307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2M2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8190307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9610" checksum="AEB78D2E645FACB0" modified="2024-11-27" version="1">MTQVWVSDPRLDSVHQFCSLVCEYRDWVALLAAAPPVRFKDLTISGTTSYLLAVPGVDIKKRGAGCKDGYGYYVAVGAREELDLLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3L7</accession>
    <name>A0AAV6V3L7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000169">
        <property type="protein sequence ID" value="KAG8191002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3L7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12101" checksum="2C6A12E84B1FA7F2" modified="2024-11-27" version="1">MSRNGIAHIGTAPYHPNSNGIAEQAVRTTKSALKKITEDNFAHCWQDSSSPTGAHLQQPRADPLLKTCLVDRCADLLQETGNSTKKQGPCYTSVYAGRELVWARNFGRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4V7</accession>
    <name>A0AAV6V4V7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_024861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000175">
        <property type="protein sequence ID" value="KAG8190728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4V7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8190728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25077" checksum="4C35CEC29173ADF7" modified="2024-11-27" version="1">MNDQKKTFLISSQTFLCLLTLVFLGLASTYYKVIGFFFRNLTKLSYVTCYNSARRGNLADSNYFLDERSYSFSPSDRKESLLSELTCSTQAKTEWKYKKRKTFDCRKLESEEIGSLYPSSVPVILEKASSNGTPTAQKEKYLVPRNITVADFVLMVRKNMFLHNDASLLLVAGKEILHSSFKMGEVFDECKDEDGFLYLAYNAYKSFNYSKDSYGRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4X2</accession>
    <name>A0AAV6V4X2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000151">
        <property type="protein sequence ID" value="KAG8191820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4X2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7745" checksum="BC8AB5908EBF7CFC" modified="2024-11-27" version="1">MGRKRKSTAKKSEEMRKKRQAPVVSSAVVQQEDAAENSLNRIRELNTHVPMFQLPLLYLFLQMNTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4X7</accession>
    <name>A0AAV6V4X7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_008793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000153">
        <property type="protein sequence ID" value="KAG8191729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4X7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8191729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="198" mass="22952" checksum="AE6D9767F36F9F89" modified="2024-11-27" version="1">MACILCAELWTGYQEYEKPTEQIPVELLPFLSKRPGLCIFESKPAAPSPKQQKVTVTPRPQQPPQRSQGKEKPMNPPESNQAYHCEFCPFVANSIQQFKLHLDQHKNAPPQQQNVAQCQICLQVFKSTTALRSHMLTHTNTQQHVCQYCEKKFKTAATLRNHVRMLHLGEQHVCPICDKVFNNDTYFRRHMMSHQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5C0</accession>
    <name>A0AAV6V5C0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000149">
        <property type="protein sequence ID" value="KAG8191950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5C0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="10567" checksum="199A72E6327AA597" modified="2024-11-27" version="1">MNFEPQSSALCQRRLRIHQTIALREKPVSQRTDRQERYRLVASIIPMWEFRNIVKSVKLKNLILKIDKSSFHWRLSYFYSFASNHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8L7</accession>
    <name>A0AAV6V8L7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000141">
        <property type="protein sequence ID" value="KAG8192309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8L7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="545" mass="61769" checksum="37106902702660A0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V966</accession>
    <name>A0AAV6V966_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_003777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000125">
        <property type="protein sequence ID" value="KAG8193290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V966"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000027">
        <property type="entry name" value="putative deoxyribonuclease TATDN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46363">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46363:SF1">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8193290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="894" mass="101315" checksum="EA0769CA4D382F00" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9M2</accession>
    <name>A0AAV6V9M2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000124">
        <property type="protein sequence ID" value="KAG8193332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9M2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10394" checksum="D6D3E7ADDB2B4A4E" modified="2024-11-27" version="1">MTIGTPDYNAESGPNPEYQMLINIRDRVSSVYDVNNLKLSMGMSKDFIHANSKVKKIGNLEMLCANSLIGNWIEKWKNVRHTINTLVGIQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAM9</accession>
    <name>A0AAV6VAM9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_022999</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000124">
        <property type="protein sequence ID" value="KAG8193371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAM9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="57"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="457"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8193371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="613" mass="68248" checksum="E51960773197C545" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VD50</accession>
    <name>A0AAV6VD50_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acrosin</fullName>
            <ecNumber evidence="3">3.4.21.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_000226</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.10" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000118">
        <property type="protein sequence ID" value="KAG8193591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VD50"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000015">
        <property type="entry name" value="Atrial natriuretic peptide-converting enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF8">
        <property type="entry name" value="ACROSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043439943" description="Acrosin" evidence="11">
        <location>
            <begin position="24"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="219"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8193591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="462" mass="52931" checksum="32F64110DA7A96FE" modified="2024-11-27" version="1">MDIRNGTLVFICVCLLLFTFCESRRNKRTRSRAKSENYEAIDDLNNPAYGEWGPWSKCNRQCRQFKNRRCIDFEVCENKTQRIYRACQSATCKHKMLVVVHNSNNPNRRPSKFKVLNHLTPYIYTDWSSWSPCLSTCYTRRTRTCRFPEICGANSVKEDYKACYREGDECERKYLERFQHLSKPEKNGTNPDSFKVQNVKHPLDNMTCGVSDVAPELRITGGRQAIKGSWPWQVLLLNGHLEPFCGGVLLSAEWVLTAAHCVRRRLFVRAGEHDLSHFEDTEQQERVGSIFVFPEYDPQTVDNDLALLRMRVPFELNKFVQPVCLPALGEKLPYYSRATILGWGKRRNFSSFGTDILHQAEVPVVPSDECKDSYDEYYITENMMCAGYESGRVDSCRGDSGGPLLHPRQGDGNWAVYGITSFGDGCGQKRKYGVYADVLIHLGWIRGIIQNGNIGSTEVEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDC2</accession>
    <name>A0AAV6VDC2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tubulin-folding cofactor E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_011498</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000113">
        <property type="protein sequence ID" value="KAG8193948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDC2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17044">
        <property type="entry name" value="Ubl_TBCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044079">
        <property type="entry name" value="Ubl_TBCE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="10">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8193948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="525" mass="59340" checksum="18BBAF65F0BA16D4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDC4</accession>
    <name>A0AAV6VDC4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000115">
        <property type="protein sequence ID" value="KAG8193696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDC4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9536" checksum="1BE4D3FDEAE47C30" modified="2024-11-27" version="1">MPKKNVLSTSRNRLPKTQGRPLVRIKAELGLVYSSLDDHSPAKHWVSQDGLSPSSRVSLAGTVYKQFIALLGLNYGLGCVRNNRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDL0</accession>
    <name>A0AAV6VDL0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_003043</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000109">
        <property type="protein sequence ID" value="KAG8194102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000023">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000031">
        <property type="entry name" value="Probable copper-transporting ATPase HMA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="778"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="825"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1222"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1250"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="76"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="152"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="347"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="423"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8194102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1337" mass="146341" checksum="A216EEB413A65493" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDY0</accession>
    <name>A0AAV6VDY0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000113">
        <property type="protein sequence ID" value="KAG8193871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDY0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10728" checksum="885D82A09B76B88B" modified="2024-11-27" version="1">MTARFLHPTRIQVIKGSLLKKTNIKREFLRNGAEFFVLIRSIDIYDDGFSTDHLNLYLVEPAPQQRWDRKERADTCYTFFASNKNSIVLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF87</accession>
    <name>A0AAV6VF87_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">JTE90_004528</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000105">
        <property type="protein sequence ID" value="KAG8194298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01243">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05597">
        <property type="entry name" value="STKc_DMPK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000014">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000032">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000017">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031597">
        <property type="entry name" value="KELK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014930">
        <property type="entry name" value="Myotonic_dystrophy_kinase_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF66">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GENGHIS KHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08826">
        <property type="entry name" value="DMPK_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15796">
        <property type="entry name" value="KELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="17 22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="19"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="29">
        <location>
            <begin position="294"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="26">
        <location>
            <begin position="970"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="24">
        <location>
            <begin position="1040"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="28">
        <location>
            <begin position="1114"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="27">
        <location>
            <begin position="1490"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="907"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1528"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="377"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="666"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="844"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="930"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1530"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1589"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1630"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1640"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KAG8194298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1693" mass="192779" checksum="4251399C84DEC6B7" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VH12</accession>
    <name>A0AAV6VH12_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_021404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000096">
        <property type="protein sequence ID" value="KAG8194943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VH12"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="173" mass="20169" checksum="A7043E5D5D4720A9" modified="2024-11-27" version="1">MHMLQMLEKDVRLRDAAIALQPSAKDLLNEASALLHWIKPPKHVVDGRLNYGYAIQELLRTMFGSSDQEDGSDYNKVAFWQVNAVLRDCRLDPCLAYHPDKCFRHGIYLEVCVPLVYTLIVEKWDRFRSPMVHFCTLGDLLMFINRCYFRKTVHSLQRLCTVFLSHLSIARPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHS5</accession>
    <name>A0AAV6VHS5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000072">
        <property type="protein sequence ID" value="KAG8196317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHS5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7731" checksum="C99174587457E3D7" modified="2024-11-27" version="1">MDRLEWSRGTPSWARLLKGGRVQRRLRQSNVVHTNGPVGMESMNPVVGPTPKWWKSPTAFEAAHPRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIC6</accession>
    <name>A0AAV6VIC6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_001121</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000076">
        <property type="protein sequence ID" value="KAG8195883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIC6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000001">
        <property type="entry name" value="Dynamin 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000172">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="16">
        <location>
            <begin position="22"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="15">
        <location>
            <begin position="648"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="518"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8195883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="740" mass="83142" checksum="A2B1CFF25408398B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJA7</accession>
    <name>A0AAV6VJA7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_027587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJA7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF240">
        <property type="entry name" value="GH14155P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="3">
        <location>
            <begin position="148"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8196875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="585" mass="67762" checksum="7973B9529F03D5D3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKL6</accession>
    <name>A0AAV6VKL6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_007941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000074">
        <property type="protein sequence ID" value="KAG8196216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKL6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043383784" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8196216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20573" checksum="ACA3C9F5015D1210" modified="2024-11-27" version="1">MATIPKPWVLLLLLLAALSSSTNHQLTTPLSSAFLKMPSLQRAASHTALPSGRGYDEGWKPKPEVLIVSEKKPDSQMKDITPILACLLPLICILMMLMNKNMMMPPMMPPMMPPMMMMPPMMMMPPMMPPMMPPMAARDGEGGLPLVDEKGRSFGATEGPSMADKILGMIDRMEVEYGDGRKKTWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKV9</accession>
    <name>A0AAV6VKV9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000068">
        <property type="protein sequence ID" value="KAG8196539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKV9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF2">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16830" checksum="EA4D000FA3AC1A1C" modified="2024-11-27" version="1">MSDHRPIITSLGYQLEPEEQLKRSWNFRKANWDSFTSSLDELCRNAPTHTDLDHKLQTLNKNITLAAKKNIPRGKRKKHWIPFWKEAEIDTLIKERDDAHDHMKINNTAENRAKLCELSKRVEEKIAECKRQKWSEFCSTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VL18</accession>
    <name>A0AAV6VL18_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VL18"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="165" mass="18375" checksum="674452839E459DC8" modified="2024-11-27" version="1">MYNQLKLIYTTISFTYPSNILPIMSKNQYQLQTSALQTTSACYLSTQIVMQQPQAQQSKFKIHNELLSSPGLSILCLHPPAHLFSYFCFLGEKLFEQPLFKLEGKTDGDKFAKFGMPPSSLLLGSPPCWVPPPLELVWATFAVLLVAGLHTSTLSNARGISFTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLG8</accession>
    <name>A0AAV6VLG8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_027603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000063">
        <property type="protein sequence ID" value="KAG8196895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLG8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043731176" description="Ig-like domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="39"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="123"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="220"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="315"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8196895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="568" mass="61706" checksum="98981B7F6EC75E1A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMH4</accession>
    <name>A0AAV6VMH4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">GDP-fucose protein O-fucosyltransferase 2</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Peptide-O-fucosyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_011287</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyltransferase 68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010000058">
        <property type="protein sequence ID" value="KAG8197124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMH4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11298">
        <property type="entry name" value="O-FucT-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11350:FF:000002">
        <property type="entry name" value="GDP-fucose protein O-fucosyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044000663" description="GDP-fucose protein O-fucosyltransferase 2" evidence="19">
        <location>
            <begin position="21"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8197124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="434" mass="50589" checksum="2D370172512337B8" modified="2024-11-27" version="1">MSISLKFVLCLLLFAGDTFQSEHCHLGENDDLSCQEPESKSSMYRQKRYLLYDVNPGEGFNLRRDVYMRIATLVKKLNKDSKNTLWTLVLPPWGPLYHWKSRHIGFQAQVLWSKFFDLSSLKKYVPVIEVEDFLKEHGNTIDVLYYLQHYAEGWTNNEWEERADIRDCLGKPPYHKTANGDFTGWFWDYDIISLKQFYCLSIQGYSSTLKRFLESTSAGAIMIDRAEVILHDSFGDLEYWMVRRSMVFSKKLLNIGDDFRKLYLNSTDEKDKTHLPESLTSSIERKAVGGPYVAVHLRRRDFVQARPKDVPSIEFAAQQILKHMKRLNLETLFVATDALQSEFEELQRYIPNAKRFLPNNKELKDILDGGVAVVDQWICAHSKFFIGSYESTFSFRIQEEREILGFPVDTTFNRLCGDNQTTCTQPSKWTIVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VN26</accession>
    <name>A0AAV6VN26_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dedicator of cytokinesis protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_014923</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000055">
        <property type="protein sequence ID" value="KAG8197438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13267">
        <property type="entry name" value="PH_DOCK-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF26">
        <property type="entry name" value="ZIZIMIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="163"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="4">
        <location>
            <begin position="655"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="5">
        <location>
            <begin position="1734"/>
            <end position="2163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8197438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2192" mass="251056" checksum="59D6F05A6759DF1B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VN83</accession>
    <name>A0AAV6VN83_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Disks large-associated protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000059">
        <property type="protein sequence ID" value="KAG8197021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VN83"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031616">
        <property type="term" value="C:spindle pole centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005026">
        <property type="entry name" value="SAPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353:SF1">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03359">
        <property type="entry name" value="GKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8197021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35671" checksum="48154BDF64F6EA83" modified="2024-11-27" version="1">MVSVGIVIGSAVAMEELSIQYFRDLLEKHREELKNYCQKWEENSSDKSIPDEVADEIRTTIGLTNLLLRQKLKQFGELIDDSEFKRGEKEITCIDLQGFWDMVFHEVEKIQKNFKKLEKCQSNNWVFIEEPVPKIEAKKKPTIAATAKVTVQSKAHVTAARQRLAEAKQRMMDAKKKMKEAKNDANKDFVVIESKPRENGVEEKTVDTKEQLRPALVTVEDKESLNKVSKKSTSKSSKKTAQQDMTGQQKRQKSERISKGKENLIESGKKPELLTVTAPKAPRAKRAKSPKEADVPLQCVTRSARRAMLANQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQJ0</accession>
    <name>A0AAV6VQJ0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Insulin-degrading enzyme</fullName>
            <ecNumber evidence="8">3.4.24.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Insulin protease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Insulysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_021560</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Degradation of insulin, glucagon and other polypeptides. No action on proteins.</text>
            <dbReference type="EC" id="3.4.24.56"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.56" evidence="8"/>
    <dbReference type="EMBL" id="JAFNEN010000041">
        <property type="protein sequence ID" value="KAG8198306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQJ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="13">
        <location>
            <begin position="36"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="14">
        <location>
            <begin position="199"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="15">
        <location>
            <begin position="383"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="16">
        <location>
            <begin position="771"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8198306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="996" mass="114277" checksum="70067EC5D97D6161" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRE0</accession>
    <name>A0AAV6VRE0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">General transcription factor 3C polypeptide 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_003664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000029">
        <property type="protein sequence ID" value="KAG8199237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRE0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="470"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8199237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="882" mass="100833" checksum="2C40F11B797982C8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRY7</accession>
    <name>A0AAV6VRY7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-related protein Rab-21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_001813</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000033">
        <property type="protein sequence ID" value="KAG8199018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRY7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04123">
        <property type="entry name" value="Rab21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000550">
        <property type="entry name" value="ras-related protein Rab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041833">
        <property type="entry name" value="Rab21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="179"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8199018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="215" mass="23630" checksum="43919247E0322C86" modified="2024-11-27" version="1">MASNSGSSGRSFSFKVVLLGEGCVGKTSLVLRYVENKFNEKHFSTLQASFLTKKLSIASKKVNLAIWDTAGQERFHALGPIYYRDSNGAILVYDITDEDSFSKVKNWVKELRKMLGEDVCLCIAGNKMDLEKERAVPIGEAESYAASVKAKHFLTSAKQNRGIEELFLDLTRRMIEKAEATEQGSSLGRGSNPRRNVVIVDDEPPQPKSGCCGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS29</accession>
    <name>A0AAV6VS29_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000034">
        <property type="protein sequence ID" value="KAG8198876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VS29"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="209" mass="24361" checksum="9CDD3056FCB885F1" modified="2024-11-27" version="1">MEYRRQRSLTYNDSSTSDSSTSSGSDITNEKSRQRKATRKRLRPKFQYQKVTRLVNWRRSGRRRMPTSAWKPDRTPPRRRPSTSDYGDSSRENQDDSSTSESYNDSSTSDSSTSSGSDITMKIPQRRDKKETSPQVPVPKVTRLVNWRRSGDEECNLSLEIRQDSTEKRLRPQVQVPESRLVLVNLRQSEASGDEECHPAERRERRIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSQ9</accession>
    <name>A0AAV6VSQ9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000022">
        <property type="protein sequence ID" value="KAG8199947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSQ9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8235" checksum="53E423DCAD4504CC" modified="2024-11-27" version="1">MDTVLPNHRIEVKSIAMIREEPSLRCQTGPQYIISKTSVATEYDHNGNDQMNQGKTHVQSASYESFSMSLIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSS5</accession>
    <name>A0AAV6VSS5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSS5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF135">
        <property type="entry name" value="SI:DKEY-77F5.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="132" mass="15202" checksum="6D3527EAF450F2AA" modified="2024-11-27" version="1">MVWGAFSWHGMGPLVILDATLTSQQYLQLLADHLNPFAMFQHPGGIAVYQDDNATPHRANIVRAWFDEHDGEIQRLNWPPRSPDTNPIEYIWDALDVRLRALNPSDGFQSLADSLPRRIIELRRARRGPTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT35</accession>
    <name>A0AAV6VT35_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_001777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000033">
        <property type="protein sequence ID" value="KAG8198977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT35"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="169"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8198977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="316" mass="35481" checksum="3748577087B09895" modified="2024-11-27" version="1">MRFIRKNSNLPPCFNYPIIVFFFILLSLEQSGNLIILDQMSGILPALVCFFLLLGYVCAQNFVDDQVCPSNSRCIDQGRCRSLSQNGNSRPIVCGYINNWRRRICCPPRRRGPLNPTRRPPTTTTVRNSPTRRQTVRIGVTSPSRPPFYSPGTRNTECGRTNPSLSGFIIGGEDAQQGAWPWMAAIHERDPMGALYPSCTGFLIDRRHVVSAAHCFDRRDPSFYSTRIGHVNLDQAEEYPISRILVHPGYRARAFYDDIALVTLTRAVDIPDFSPICLPWGRDFINITGMGTTVAGWGVTAVGELGRVVYGLYSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VV28</accession>
    <name>A0AAV6VV28_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_028543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000016">
        <property type="protein sequence ID" value="KAG8200362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VV28"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF24">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="319"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8200362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="512" mass="57850" checksum="1CCBE0CE1BC68C91" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVX8</accession>
    <name>A0AAV6VVX8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_009465</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVX8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000180">
        <property type="entry name" value="Member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8199631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="225" mass="24371" checksum="7AE991E6B73CCA27" modified="2024-11-27" version="1">MTPAYKDPVMANRGGAQRPNNLQQGKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQDTFSRAKTWVKELQRQASPNIVIALAGNKADLAAKRAVEHEEAQAYADENGLLFMETSAKTAMNVNDIFLAIAKKLPKNDLSSGNGGANDGRGGVNLSENSQQSGGGCCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VWD5</accession>
    <name>A0AAV6VWD5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Down syndrome cell adhesion molecule-like protein Dscam2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_002747</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000009">
        <property type="protein sequence ID" value="KAG8201074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd20956">
        <property type="entry name" value="IgI_4_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20958">
        <property type="entry name" value="IgI_5_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000017">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000104">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000324">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000719">
        <property type="entry name" value="nephrin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056754">
        <property type="entry name" value="DSCAM/DSCAML_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25059">
        <property type="entry name" value="FN3_DSCAM-DSCAML_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1229"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="37"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="147"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="239"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="330"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="428"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="520"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="608"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="726"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="814"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="914"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="1016"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="1110"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1260"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1313"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1387"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1260"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8201074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1482" mass="164812" checksum="1F9700BFD595F0D1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXN7</accession>
    <name>A0AAV6VXN7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_000572</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
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        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        <location>
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            <end position="403"/>
        </location>
    </feature>
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        <location>
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            <end position="101"/>
        </location>
    </feature>
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            <end position="150"/>
        </location>
    </feature>
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            <end position="201"/>
        </location>
    </feature>
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            <end position="510"/>
        </location>
    </feature>
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        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="438"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8200493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="510" mass="56759" checksum="43C726F960422BCA" modified="2024-11-27" version="1">MASTPEQVVCTPTFVFPTAFPVNGFQIWGKDDQKGDVLAFCNNAPWNDYRAAGHVLTGFDPRNHLANFHVAAAAASQSQPLQHTEDNSKGKGGNRGVAKNHISNQNDFSAARNLLVASAPPAFPGIPESVGLKIPNPNIDKQTQQQQQQQAQQQQQQAQQQQQQQQQTAQQQQQSQTQQQSQQQHPHQHTHEDGTGPLVDKDGRLWPCPSCKVPFKQASELQAHLSSHTKGEQRRVPCDVCGKCFASNDRVRIHVKSAHGEKSCSCEVCGSGFSYRCKLLDHMRTHSGEKPFHCEVCGKSFSQKNHLTRHSMIHTGERPYPCDFCGRQFYRKDKLTRHRRIHTGEKPFHCGMCGKSFLQKFHLVRHSMIHTGERPYPCDFCGRGFYRKDKLARHRRIHTGERVTGQPRKRGGGQFNAKMPQNAAARHNSIMAHHVGTSVQNPTVPSVASAGSSTVKMESTMNTEQPIPSTTASTVNLSFAPPTLTPTISPSHYRASPYKPEWQSPPSGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZ52</accession>
    <name>A0AAV6VZ52_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000006">
        <property type="protein sequence ID" value="KAG8201335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZ52"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7903" checksum="E0AABEEF790E8D0C" modified="2024-11-27" version="1">MAAKFRLRKLRLASLYLLTHRLCSPSMTLEWIYLDVHPIWSFRYFLEVTATLGSTTNAATTVTSEAHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W0C7</accession>
    <name>A0AAV6W0C7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_016825</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000006">
        <property type="protein sequence ID" value="KAG8201348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1770.10:FF:000001">
        <property type="entry name" value="acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="18">
        <location>
            <begin position="221"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="377"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="16">
        <location>
            <begin position="847"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="19">
        <location>
            <begin position="1664"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="20">
        <location>
            <begin position="2004"/>
            <end position="2320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8201348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2443" mass="276476" checksum="9A493FCA96E0AD35" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCZ3</accession>
    <name>A0AAV6TCZ3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH endonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006595">
        <property type="protein sequence ID" value="KAG8155788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCZ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7549" checksum="CC908C57EEB713EE" modified="2024-11-27" version="1">MSPQIRRGDKPAEFKHKISGGKETNRDNLVTAECETGRSQRESHARKAWGNVRLGRERAGDGLCSKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TET4</accession>
    <name>A0AAV6TET4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005864">
        <property type="protein sequence ID" value="KAG8159489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TET4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8159489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="185" mass="20600" checksum="4BB42B0983975009" modified="2024-11-27" version="1">MSTSKIRRDNPLNFKHINKRSEKKTKDSLVTATVKRGRSPAPNPASQRAWGKMWRLGVSRAGGRTSAASPLDRAVAQSGCPPPRPIADLGSIRMRSPWSRGLEGATLIGWTAEVGRIRDHVPSRRGRHRRPAAFHLWKWRFLRRITLGPEDGETMPGQDEAPEETLVEAVAVLKCKSIEIWVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TH49</accession>
    <name>A0AAV6TH49_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013571</name>
        <name evidence="1" type="ORF">JTE90_028299</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004346">
        <property type="protein sequence ID" value="KAG8171162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010004210">
        <property type="protein sequence ID" value="KAG8171277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TH49"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="88" mass="9843" checksum="DE3E7FD9C5962BFA" modified="2024-11-27" version="1" fragment="single">MTSVLDMDDIISNLGNGDTIIDKEIITEYLLVIQEKARLEAITPRTQEVSDKLQELQEKEANVATVTFTQLLTNLPTLAKTNPEIDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIK6</accession>
    <name>A0AAV6TIK6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003795">
        <property type="protein sequence ID" value="KAG8171577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIK6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="19037" checksum="AFBB4744D5287B5B" modified="2024-11-27" version="1">MKLRGNTLYTMKSWANGRNSYLCNCCYREHRTRGNKITDHPTLITHHKTTPNFLQGREVLYHKGCRSKPYKARYKAQTHLTDEQTSGRIAGDTQEPLRQGQKINDFLGSQSQFDTEDDNTAQYDITPFLANTNWYNFRPRPNKRNDLTLSEKSFNFATEVKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIX7</accession>
    <name>A0AAV6TIX7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003842">
        <property type="protein sequence ID" value="KAG8171558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIX7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="205" mass="24006" checksum="FD5650AAC793E98F" modified="2024-11-27" version="1">MVAETYQENVFGCCPFVIIPSINKFCQLNPELMYELEMMMTKRTAFITDEDERIFNNVLGKDEILVTDLLDLAGCLYKIAYDLKEVIYILPWMEQLDMTKRVMSIVSSMILNLFSTDSEAVRKLYRANMIDSPYDMNKALETIFKGGNHPVKEMYIDFMGGWFNVKRAESWIEKRKKVLAGLEFDARENMYRKRMSTTKTLMESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJ24</accession>
    <name>A0AAV6TJ24_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003861">
        <property type="protein sequence ID" value="KAG8171536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJ24"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="119" mass="13550" checksum="CE87D21F2C19078C" modified="2024-11-27" version="1" fragment="single">ILIGLVFSVRWNIFKKTPYVIEYPPRWSSASSKVSFSEIEEKTSIIIINRNRRRGQLLGDHIRCLFISADPFSGSDVKPYPKRHEWKEGVVIGEDSKENIGNGIDSGQEALARGFWLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJ55</accession>
    <name>A0AAV6TJ55_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">15-hydroxyprostaglandin dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="3">1.1.1.141</ecNumber>
            <ecNumber evidence="4">1.1.1.232</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eicosanoid/docosanoid dehydrogenase [NAD(+)]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prostaglandin dehydrogenase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">JTE90_009287</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78836"/>
            <dbReference type="ChEBI" id="CHEBI:90697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48641"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.232"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:23261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90866"/>
            <dbReference type="ChEBI" id="CHEBI:90867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H(+) = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:41596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78325"/>
            <dbReference type="ChEBI" id="CHEBI:78329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:41597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67026"/>
            <dbReference type="ChEBI" id="CHEBI:78311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41573"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>prostaglandin A1 + NAD(+) = 15-oxo-prostaglandin A1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41263"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57398"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:85072"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41264"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16477"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57397"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16478"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57400"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="1.1.1.141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:11877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>resolvin D1 + NAD(+) = 17-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:50129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>resolvin D1 + NAD(+) = 8-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50124"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132080"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50125"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>resolvin D2 + NAD(+) = 16-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:53589"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>resolvin D2 + NAD(+) = 7-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137497"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:53585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>resolvin E1 + NAD(+) = 18-oxo-resolvin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:91000"/>
            <dbReference type="ChEBI" id="CHEBI:91001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:49245"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.141" evidence="3"/>
    <dbReference type="EC" id="1.1.1.232" evidence="4"/>
    <dbReference type="EMBL" id="JAFNEN010003441">
        <property type="protein sequence ID" value="KAG8171874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJ55"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047034">
        <property type="term" value="F:15-hydroxyicosatetraenoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016404">
        <property type="term" value="F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG8171874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="177" mass="19354" checksum="62B6C213B9CB2F78" modified="2024-11-27" version="1" fragment="single">VCVADIQEEKGKRFVEDLQKRYGSGHAIFSTCDVTKETDFRNTFDETLKAFLKIDLLVNNAGVSFCEAKRILQVNTLGTLNGCQTAIDYMSKSSGGNGGIVINIASIVGLMPCPEAPVYAATKHFIVGLTRSYGASVHYSEHGITFSALCPSIIETEMAARAKELLQKRPKRWSAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJ82</accession>
    <name>A0AAV6TJ82_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_019972</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003612">
        <property type="protein sequence ID" value="KAG8171733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJ82"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="66"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8171733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="293" mass="33137" checksum="C6A39DA1DEBF051D" modified="2024-11-27" version="1" fragment="single">ETQTSLHFQFRMGIGTICGILMEVCTAIFSTMRADVIPTPSTEEEWREISSDFWELWNFPHCIGAMDGKHIKISPPPNSGSIFFNYKGDFSLVLLALVDAKLKFTFVDVGTNGRISDGGVWDKCALKAALSHNNLQKPNATVLPGTRVKVPSVIVADDAFPLTTTIMKPYPGRGMSHEERIFNYRLSRARRVSENAFGILANRFRLFQTTIYGTPAKVKAYVLAACCLHNFLRMRILEREGMDAIQGEQLMTETENSEWQQRALAFVPLQRGNWRGNQQAKLVRHKFTVFQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKN6</accession>
    <name>A0AAV6TKN6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002995">
        <property type="protein sequence ID" value="KAG8172188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKN6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="164" mass="18370" checksum="0003F723A9B7CC89" modified="2024-11-27" version="1" fragment="single">MRRALTLCSSVDTVSRLFIEKSLGCTKVLANLLLERLEFEGFVLPTEELGVFSVDAAQLNEYGWLNYFPVDENKENGNEVNYQNSLPAYSPTQESVVTVENAMNVDNYVPESNDNYYEARSNAKHSKPEDYGSSSAFNNNGNYSDENDSPVISDITNVESSIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TL59</accession>
    <name>A0AAV6TL59_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_017588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="JAFNEN010002652">
        <property type="protein sequence ID" value="KAG8172507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TL59"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="175"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8172507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="289" mass="34052" checksum="7152DF2474C1ACBD" modified="2024-11-27" version="1">MKLETYHSFRQAFLGANNPVAMSHIAALEKDPYLIHQTKLLLSHMRGVPWNVEHYTSQFRNAPAKQRLEETLLIFLLHSAMVVKQEIFNRTFMKPGSNDVNHVWVMLFKQCFETLTTLLYKVKWTTDNHKNLDMLVLKLIYQGQCRALRDFMKDELHIPMVTHTTQAEMYFEKLNELHISQMGSSFWRLLHWVAEAMDRPDRDEVAKQSWRTLMTYSLYRFLICGVCRMHMQTIVTELKDQLKSVTVSNRELWFNIHNKVNSIIAKPNTSYSKSELAADAEFMVQAFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TM30</accession>
    <name>A0AAV6TM30_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of rDNA transcription protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002311">
        <property type="protein sequence ID" value="KAG8172837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TM30"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14916" checksum="F0FF33487DE0B076" modified="2024-11-27" version="1">MVASHHWPLDQAHEPSVRTCGSSRTEQDYYRNDESSSKGLIGPAFAVRIHTENQDQASFCPFALREVSVLAELALGHLRYHLTDVPPQPNNPPESVLGADRALQGGSALGARSVILTGRFPLNRVSKETMKAVVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMH4</accession>
    <name>A0AAV6TMH4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_003924</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001996">
        <property type="protein sequence ID" value="KAG8173187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMH4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="21"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8173187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="292" mass="33465" checksum="80B36ABE6C6BF157" modified="2024-11-27" version="1">MHTIFVVALLDIVLSVATVGGNVMVIFAVMRYRQLHSVTNVFILALAAADLLVGLNVPYYILFYFDFRELACHRISCLLRYWFTIYAGGCSMLSLIGVAVDRYIAILHPLSYHRMVRNRYASLYVLMVWLSMGVVSSLPLIGIGETFDPSRECDLYYTHTKEYALAAVASLVLLTFIVTTSLYSVIFKAAWRHKRAVVALDFNHKIRQETKTARMMALVMGVNFLGFLPYLTVITMRYLDGMNQERIGFFKPFVVCCYFGKSAINPVIYGWKNKEFRTAFRRIASFRRNVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNT5</accession>
    <name>A0AAV6TNT5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001770">
        <property type="protein sequence ID" value="KAG8173438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNT5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009422">
        <property type="entry name" value="Gemin6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046856">
        <property type="entry name" value="Gemin6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046857">
        <property type="entry name" value="Gemin6_Sm-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14710">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14710:SF2">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06372">
        <property type="entry name" value="Gemin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20417">
        <property type="entry name" value="Gemin6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="77"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="165" mass="18789" checksum="4707D6F452B2D9EF" modified="2024-11-27" version="1">MIVDPNYTMKFSDCLYKFVSVKTLPKNQVREGWLTTIDPPTGNLVLVTFKDDCYATKQIIFIMRDAYEHVTVLKEADPSIIPVLQNLFAPENSLSDINTPERKEQLVSWLKQNRLPIREDENGTALVICESVTIRPPYIADSCSGTNGRVLMLIRDLVDKLPMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TS42</accession>
    <name>A0AAV6TS42_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_016099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001227">
        <property type="protein sequence ID" value="KAG8174403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TS42"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="497"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8174403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1158" mass="127050" checksum="DB5A749E25CA37B0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTH5</accession>
    <name>A0AAV6TTH5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001118">
        <property type="protein sequence ID" value="KAG8174873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTH5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="219" mass="25468" checksum="E9923F15ECF0CB7B" modified="2024-11-27" version="1">MILVVSLNDWKVDVHLCQFVRNASGELVPSENEIILSPFLWVSLCNSMNNPSFIDLPTTFESFSLVENELFLAAIENRYVSLQRCGIQNNYERYFIPGTLTMEDHQWGRLKYSNKLISDILTEYLIKHELKSWILKEAENHPYQTVVNKSGAEKALKTSLCGLMKTHLDRTMNTDFYSALTKLDLKQIAYEFVQENKPLLRFIGEELFDVTDFVRQLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTL2</accession>
    <name>A0AAV6TTL2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_013051</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001142">
        <property type="protein sequence ID" value="KAG8174789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTL2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015889">
        <property type="term" value="P:cobalamin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002157">
        <property type="entry name" value="Cbl-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051588">
        <property type="entry name" value="Cobalamin_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559:SF18">
        <property type="entry name" value="TRANSCOBALAMIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559">
        <property type="entry name" value="TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01122">
        <property type="entry name" value="Cobalamin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CUB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="224"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8174789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="497" mass="56390" checksum="D5C6CF5D12F56CB1" modified="2024-11-27" version="1">MLNFTYFRIEQSASCRLDSVEVLGKVSPEEDWKSMKKLCGDSLPPTITFEGRQMRIKFRSDGHNNFFFGFYADYSFNDIAPPPTTPPTIVTRSPREVLNDEVSLAKKKLVDWFMGLRRKGTQTKKWGHQLPRIAVALFLADQENFQLENRTMYEMNTELTIQLLSKLQGGGHLKRRDLSLYIPALMVTCVDPRNFHGRDLVAELRSDIESNNGTGSPFELLVLCNAGDAMSDRDVKRMSTIFDSQHRPFWADNQAMATLALACASAQPGVTVDERTLLDMAQELKKRQFRNGTVDNIKTTAIVIQALAATESLDRDFDFWAAIRALLSAQREDGFVGSFLDSYYVLPVLSRSTLLNVTANHCKRPETSESEELIELQGSRGSRVSVTYSVVIGTDVDLKRTWTLKVPVNSSLYSIMETVQKLDSRQQVEYNVIDGKPFVSSVMGIQDDVETGFYWFTFLRKHNAEDSMLVEDSPVDMKIEANQELILWYKSGQWNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUK6</accession>
    <name>A0AAV6TUK6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001007">
        <property type="protein sequence ID" value="KAG8175418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUK6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="101" mass="11326" checksum="ECCC978335638EC9" modified="2024-11-27" version="1">MIKSIDEMRMHVALSIYLQNVFSMSVEFGFSGFLFFSGVVVFSLGMLFLEKWSPPRKWVLAGEFGGKGGVTVRTQPPTFSGGKRIVQAIQGRRVQTRDVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUS2</accession>
    <name>A0AAV6TUS2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_017396</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>glycine + S-adenosyl-L-methionine = sarcosine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57433"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.20"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19938"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000966">
        <property type="protein sequence ID" value="KAG8175675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUS2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017174">
        <property type="term" value="F:glycine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006111">
        <property type="term" value="P:regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046498">
        <property type="term" value="P:S-adenosylhomocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046500">
        <property type="term" value="P:S-adenosylmethionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901052">
        <property type="term" value="P:sarcosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000113">
        <property type="entry name" value="Glycine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.46.10">
        <property type="entry name" value="Glycine N-methyltransferase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014369">
        <property type="entry name" value="Gly/Sar_N_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16458">
        <property type="entry name" value="GLYCINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16458:SF2">
        <property type="entry name" value="GLYCINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000385">
        <property type="entry name" value="Gly_N-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51600">
        <property type="entry name" value="SAM_GNMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="7 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="14">
        <location>
            <begin position="44"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000385-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8175675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="278" mass="31952" checksum="88119944499D9AEF" modified="2024-11-27" version="1">MDYQALDAAVADVWDDYVGDVHHRLAHYADFLVDFLRKHNSRHVLDAACGTGIDSIMLLERGFKVTSVDASQGMVHMVLKKRWDRRKEKAFDEWEIVEADWLTMPRNLTMAGKRFDAIICIGNSIPYLKDMEEIKLAIQNFHHFLKPGGWLIVDHRNFESNLGKGHRPNTCMYYSGTVFKVNTVEQTSEGIIRNVYIDSSSDKATSLAKYNKENSTSGKVNFKYRIFPIQRGDFTSILRAVFGEGSKHEVYGDYKSSKSEENTSFFIHFIQKETENSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TV38</accession>
    <name>A0AAV6TV38_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_009137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000994">
        <property type="protein sequence ID" value="KAG8175503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TV38"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002331">
        <property type="entry name" value="Lipase_panc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00823">
        <property type="entry name" value="PANCLIPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043361240" description="Lipase domain-containing protein" evidence="6">
        <location>
            <begin position="16"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8175503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="395" mass="43529" checksum="63C2A1BBE5E23AD0" modified="2024-11-27" version="1">MLLIVLSVLVCSSEAEQLDESNAAFTNSCISDLGCFYTGPPFYDPVERPISLPPSNRTDEVKFLLFTPESPVEAYNIKPDNESVQESVADSGLKTAILIHGFLTTMDKDDIRHHMKDAILRQGGYNVIIVDWTRLNGEPYAQAVANTRVVGALIAKLINLIMDLKGVQAESFYLIGHSLGAHVAGYAGERIKNLGRITGLDPAGPWFSATPPEVRLDPTDALFVDVIHTDASALVFTGFGIGMPIGHMDFYPNGGSHQPGCTGSSQMDNVIGTIINDTIRYTNPSCDHSRANELFLESIDDSRCRFLAVHCANYADFESGLCQPQAGEGVSEMGFHNKRIQGLKQPAKFYLKTNGQSPFCNEDSIKIAEPKKQKGVIDWFHDWVDRLKRFIHSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TV75</accession>
    <name>A0AAV6TV75_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_013405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000948">
        <property type="protein sequence ID" value="KAG8175855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TV75"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="338" mass="37295" checksum="C5B372650C978F55" modified="2024-11-27" version="1">MRGSVQLETNLGVLPPNTPVGGGEDLMYPISIRELARYKIKYTSAAGPDGVTAKVWNKVPDRVKAKLFTIWVRVEPKLDSKQCGFRPRDGIAFCISQLDQVLSDTRNEKRGLCLVSLDLCKAFDSVSHQAIFHTLESLGLDKRFISYLRYVYGNGRTRLTYGGNESAPILPGRGVRQGDPLSPLIFNVVFDNVLRSVPDHLGLRCRGEWISKLAFADDLVLCAENAVDLQHVLDTALPVVRACGLKVNEQKSVSLTWLACGKDKRRIYDHRPTIKVENRPIAALGVDGSFKYLGVKFSPCGEAVLWSEGQSGYLAEFQTETTAEDVLFGSPSSASVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TX04</accession>
    <name>A0AAV6TX04_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000892">
        <property type="protein sequence ID" value="KAG8176348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TX04"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="119" mass="13974" checksum="8C1A6D296155F955" modified="2024-11-27" version="1">MIAWLSRKLQLIPMAQGISFFNDSKTAETYFHGTINSFICKFQGNLRTETACNRQLLYEFGRTKTRFSFARSGLGNRSSDQIFRLMELAMLMAVVDWAWERNFREPKGRFSFSKRKILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXN6</accession>
    <name>A0AAV6TXN6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pleckstrin homology domain-containing family G member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_017538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000875">
        <property type="protein sequence ID" value="KAG8176481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13243">
        <property type="entry name" value="PH_PLEKHG1_G2_G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043324">
        <property type="entry name" value="PH_PLEKHG1_G2_G3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025717">
        <property type="entry name" value="SAP30_zn-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924:SF2">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13866">
        <property type="entry name" value="zf-SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="330"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="534"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="752"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="882"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="942"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="882"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1142"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8176481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1665" mass="187070" checksum="388AB5BBF9A43AB2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYB0</accession>
    <name>A0AAV6TYB0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000849">
        <property type="protein sequence ID" value="KAG8176828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYB0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8209" checksum="DC132A845DE22C57" modified="2024-11-27" version="1">MDGEQDNPPMLVPQILINDSPNPVNEMFPPNRYPVINNPFLISSIPPLSGNNHGEFFETLEVMGPYQNGQRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U007</accession>
    <name>A0AAV6U007_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="14">ETF-QO</shortName>
            <ecNumber evidence="14">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_020984</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 14">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="14"/>
    <dbReference type="EMBL" id="JAFNEN010000786">
        <property type="protein sequence ID" value="KAG8177344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U007"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000012">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="12 14" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="15">
        <location>
            <begin position="556"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8177344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="596" mass="65830" checksum="79168D2973F8760B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0R0</accession>
    <name>A0AAV6U0R0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000748">
        <property type="protein sequence ID" value="KAG8177805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0R0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="218" mass="24625" checksum="4467B2D6601AEA14" modified="2024-11-27" version="1">MTNLIPNIDDNYTFDEIQKDVIETTQEEGKATRKDSQVSLSNSEGGLSTSGSEYQPSESSSKINDESFEDKDEHQEMPEKAHSDESEVAEFLAIRNDKSKAKRKNQILCKLRNLGNNRHNCSVLKKGEGKLFVFYRPDKPVAATNYVPWVTCYGYYSKKELWKQKCPLVDGGKATKRVVAAGRNLIPAPDYIADNVKELLSSMREDKITNIIKGNRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U175</accession>
    <name>A0AAV6U175_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000757">
        <property type="protein sequence ID" value="KAG8177724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U175"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="185" mass="18989" checksum="5D5B5823F0422E9E" modified="2024-11-27" version="1">MDIAVGKVGSVVMTNAVLLDLSVVVTTVVRLCHSVVVIYAVWLDLSAVGTNAVRLDLSVVVTHAAQPDLSVALITAAQLDLSVAVANAVHLGQFAAVTHVARLVLRVVLATAVCLDLSVVVTNAVASGPIVVVTNAVRVEPLVVETNAVSPGIIVVITNAVRMYIRAVVAIVVGSGSRIFISRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1J4</accession>
    <name>A0AAV6U1J4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_023446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000775">
        <property type="protein sequence ID" value="KAG8177541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1J4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8177541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="131" mass="14351" checksum="21B8441565646C30" modified="2024-11-27" version="1">MALVDAELNLVFVDVGTNGRMSDGGVWAKCAPKAALEINDLHVPPATNLPGANVKFPYVIVADDAFPLSQNIMKPYPGKGVGDRQRIFNYPEPGGWGCFWGVGSKVSSLRETNFHFRFKCSTHRYGYLCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1U4</accession>
    <name>A0AAV6U1U4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000735">
        <property type="protein sequence ID" value="KAG8177923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1U4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="262" mass="30593" checksum="EC2DA592E7E1B825" modified="2024-11-27" version="1" fragment="single">FPEFEISNEELEEKLIAAELIDEWVVNQPVWDVQPSASSINVEPHIKKTKHIITDRQEHEAKESEEKALAKQEAKEQEERAFELEKLKLQAEASERGTAASNRQNEDVEGPRWELRKLIQSFDSKEDDMDKFEAFENLRSGVRRGPNPDYKKRNFHKQKDEAPRRENFREPFPQRRDENRRPEARRENTRFNNGHLTKRPGRTEKSYSVSLAGHTNIWENKCPRLGQRTQAATNRVDVQPIPIEEGAPHILTAKISVPVYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2B4</accession>
    <name>A0AAV6U2B4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Interferon alpha-inducible protein 27-like protein 2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_026571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000757">
        <property type="protein sequence ID" value="KAG8177729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2B4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF18">
        <property type="entry name" value="INTERFERON, ALPHA-INDUCIBLE PROTEIN 27-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8177729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="8088" checksum="E8F457C7B4301F59" modified="2024-11-27" version="1">MVVGTVLAVVGTAAAAVVGAVLFLPAAGFTTAGVASGSLAAATQSSIGSVAAGSIFATLQSAGVLGLAAGTKAAIAAAGGAVGGLLSNLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2J2</accession>
    <name>A0AAV6U2J2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000748">
        <property type="protein sequence ID" value="KAG8177804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2J2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="96" mass="9745" checksum="0F5BF89AF5E22726" modified="2024-11-27" version="1">MGARGRGNTFGRNHSKNRARGAAKPPAGTESGTGARGRGKTLGRNNSRNGREGARQNLEQGGSREMARGGAANPQSGTEPGTAARGHGNSFSRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3K9</accession>
    <name>A0AAV6U3K9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_005409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000690">
        <property type="protein sequence ID" value="KAG8178517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3K9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="145"/>
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            <end position="251"/>
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        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8178517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="570" mass="62413" checksum="655A768F57ED31BA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5K8</accession>
    <name>A0AAV6U5K8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beclin 1-associated autophagy-related key regulator</fullName>
        </recommendedName>
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    <gene>
        <name evidence="3" type="ORF">JTE90_023625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000645">
        <property type="protein sequence ID" value="KAG8179163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5K8"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:extrinsic component of phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATG14"/>
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    </dbReference>
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        <location>
            <begin position="110"/>
            <end position="179"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8179163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="53392" checksum="2D1CD25F4B8F1A10" modified="2024-11-27" version="1">MASSSDEGLDESIPEMVYQCISISDAANYRREDPCVKCPLCKKYQFNHTFHCADCVKNGNFSHSKKKCYERFADKKARKYKLEQEEQEILAKYEKTLSKRIEVEDVKLNIMLCREKIKLLEKSINAQREQISNDVKEIDDIKEKKSECIKRQQAISERISRYRSINEDKEIELNRTKKKCSYKQQELEDYKKYCVKELVTYIMPITKVPPQLSRYSSLSEDGHYADLEDAQKTTYIQGQWVLTGSPMDEIQYAVVEPCIPSSGDYSAYMSWCADHESAVSKDNLSDEDRRRFDVAYGIGAALAYTAQIVKVLSYIMDINLPKRSSYNDFCRHETARKFYHHVAKLNTNIIHLCLARQVDVTRLSAHRTISNLLLLIEPKQNERRGSLTLEQREEILNSLENSITKDLLPPDESDDDIEAEFVHISDKEDLFLDLPDTQTPTPPSSLVSSVFSSFWRAATGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6S5</accession>
    <name>A0AAV6U6S5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_007618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000634">
        <property type="protein sequence ID" value="KAG8179345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6S5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043484853" evidence="2">
        <location>
            <begin position="21"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8179345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="683" mass="60062" checksum="4283152D0BAC75BB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U779</accession>
    <name>A0AAV6U779_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000602">
        <property type="protein sequence ID" value="KAG8179800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U779"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="90" mass="11093" checksum="88665EA35484D17D" modified="2024-11-27" version="1">MRKKHLKCETRKEKKYAKSFNKRKGILLEQEILERDISLDEQNEVKAGTRYREWEEGDLKTSEREYLRSIFRHVYRKEESRLQMLIFNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8E4</accession>
    <name>A0AAV6U8E4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_016368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000567">
        <property type="protein sequence ID" value="KAG8180334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8E4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8180334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20968" checksum="399A656348BB6DB5" modified="2024-11-27" version="1">MQISSYRVFCSLNHSFENILQSKRLSKNDLTRITSEFQKASKVVKTANDCMSPIAFALIAFYAFDISYVISKLVVAPRNYFGYFRSVCHIMQFLVHFVMLVLTSSYVKAEMLKTQNMVLRANLEDPAQILLSTFLLDSCRKESVLKPMGVFKLEERFILVFIGVIVSYEVMILPYLSSTAMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8E9</accession>
    <name>A0AAV6U8E9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_012133</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000585">
        <property type="protein sequence ID" value="KAG8180118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8E9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043361249" description="Carboxylesterase type B domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="27"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8180118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="572" mass="63950" checksum="97E73CAF998F2C1D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8G4</accession>
    <name>A0AAV6U8G4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_017406</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000598">
        <property type="protein sequence ID" value="KAG8179874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8G4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000028">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000012">
        <property type="entry name" value="Potassium voltage-gated channel subfamily A member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003972">
        <property type="entry name" value="K_chnl_volt-dep_Kv1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF113">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01496">
        <property type="entry name" value="SHAKERCHANEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="16">
        <location>
            <begin position="144"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="75"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8179874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="595" mass="65923" checksum="43AD154B97D024A9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9S0</accession>
    <name>A0AAV6U9S0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000526">
        <property type="protein sequence ID" value="KAG8181242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9S0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25640" checksum="F4C8FCC078B156CA" modified="2024-11-27" version="1">MVGFQFRESFEFMVRFKEPYPSVFGVVASAVHYLFFVMPFNTFALFYVIVCHHAKQIIEILGNSMSVIKCNVNLDALLATHNRMVKMVERIDSELSAHVFFCIVFNSVAVYGFISSFIHANYQSTSRYRHLMTCFCVTSLSSFFAMTLAASFVNEALAQIATRARSMQAENIHSKMSLQIFQFCTSHQANLTVWNIVTIKRGVFINTLGVIFTYVLLIDSLDHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAD9</accession>
    <name>A0AAV6UAD9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000535">
        <property type="protein sequence ID" value="KAG8181099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAD9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="9352" checksum="F296031039138074" modified="2024-11-27" version="1">MRKGTDFHKREGRMNGESNRRAEVGGCLNEGPPTLPTLVGQHGNGRRQHRLTKMKSFVLCPKVQKEPPRLPIRWKLNFEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UB05</accession>
    <name>A0AAV6UB05_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_007761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000520">
        <property type="protein sequence ID" value="KAG8181354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UB05"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06723">
        <property type="entry name" value="PDZ1_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000002">
        <property type="entry name" value="Disks large homolog 4 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="88"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="186"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8181354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="247" mass="26553" checksum="01564ACD21677EB3" modified="2024-11-27" version="1">MESTSPLRGASYPRHFGAREMTANNESSGARVRKRDWRTGYLQRVVANSPASNDSWQANDNEQVLPNIMNLHVSNRYTNGDGEFEYEEITLERGGAGLGFSIAGGTDNPHVPEDPGIYITKLIQGGAAAADGRLQVNDIILKVNEVDLVEIPHSIAVDALKRAGNMVHLLVKRRRDPRPPDGSFEILELSKGSRGLGFSIAGGVGNQHVPGDDGIYVTKVMEGGAAHTDGRLQVGDKLIAVGAFILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBF8</accession>
    <name>A0AAV6UBF8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-latrotoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_019219</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Homotetramer in membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cationic peptide 01 (latrotoxin) family. 03 (alpha-latrotoxin) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000501">
        <property type="protein sequence ID" value="KAG8181680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBF8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="12" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="901"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="934"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="967"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="75"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="147"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="246"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="357"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="522"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="627"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="721"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="627"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="725"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="756"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8181680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1066" mass="119435" checksum="E283F96C7EBA4F31" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBR9</accession>
    <name>A0AAV6UBR9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_001456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000494">
        <property type="protein sequence ID" value="KAG8181800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBR9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="5">
        <location>
            <begin position="85"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8181800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="177" mass="19745" checksum="4E7D338D43AEE09E" modified="2024-11-27" version="1">MRAKKEKCLFGVPEVEFLWFRVNKPGIHPSKGKIEAIRAAPKPENKQQLQAFLGLVNFYHSFLPNKASIAEPLHRLLDNDAPWNWSSDHTKAFNSLKQLISSESVLTPFADSLPIVLTCDASPYGVGAVLAHVLPDGREATVAFHSRTLTSTERNYAQLDKEALAIISGVKKFHHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UC23</accession>
    <name>A0AAV6UC23_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000529">
        <property type="protein sequence ID" value="KAG8181166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UC23"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="167" mass="18694" checksum="8C7155A15DCA7135" modified="2024-11-27" version="1">MKFTNSSRKNIIVISSSLIYCIIFGIIRLNSQLFVVVRVKFGADREQPSFPFTLQYAVRNLSGPFIGFIGNKFGWRCTTVFGCLLSSVSLAACFLAKDIIYFTVLWGIAFGIGEYLLLTYGTFGTFLILSGFVLHSIPLAMLLECPETIPKIESHLEVQEKGEIFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCK1</accession>
    <name>A0AAV6UCK1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000507">
        <property type="protein sequence ID" value="KAG8181583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCK1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF9">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="189" mass="21977" checksum="012BF7EDE310EA52" modified="2024-11-27" version="1">MSTINTLLERSMIISNELKIDKLVIVMDQAIYSKDQQIRWQNDVFQKRFVLRLGEFYTTMAFLDAIGKRFRDAGFQDILIESGIVAPNSINGVINDNHYNRSIRAHKLLAESLQKFRLQTFIEEQYLAEYAVVEKAIQHINEEFPNIPATDLISPHIKDFFQNYNEYVLAKNSENQTFCGRDFAYGVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCK7</accession>
    <name>A0AAV6UCK7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000520">
        <property type="protein sequence ID" value="KAG8181346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCK7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="707" mass="79548" checksum="E9147D08F4BE9B2C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDT6</accession>
    <name>A0AAV6UDT6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DnaJ homolog subfamily C member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_026058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000490">
        <property type="protein sequence ID" value="KAG8181899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDT6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000180">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily C, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23082">
        <property type="entry name" value="Myb_DNA-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="85"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="543"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8181899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="71539" checksum="B0255743661F3507" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFZ4</accession>
    <name>A0AAV6UFZ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_017142</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="EMBL" id="JAFNEN010000477">
        <property type="protein sequence ID" value="KAG8182191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFZ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14042">
        <property type="entry name" value="PK_GC-A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000420">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="522"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="887"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8182191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1128" mass="126631" checksum="385DBF5323E74C3D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGR8</accession>
    <name>A0AAV6UGR8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000426">
        <property type="protein sequence ID" value="KAG8183239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGR8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="295" mass="33801" checksum="BBCBBA7FB8D96A71" modified="2024-11-27" version="1">MADAEVPPERLGSQELHKIILDFLDNQTYTDVEFLVQCGEDFVSFPAHRLPCAIFSPVFEDMFYGNAKGYNSPVIINDVTPNVFTVMLKFMYGSVCELTSKQRDVHFLLKLYRAATQYQIEALQCICRNKLATVTPEKHNVFHLLDAATMTNDEGIRRRCRELLETKTAEILANQQDLGDVSHAKMMTVLNLERVSFPSEFELVSWVFAWAANEHLRLKEMQENKTFRNVLDSVLGHIDLTAMNPSDFGRLLSNHPSVFSESEICKIFRNIVDPGCYDLPDWANANINRTYNYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGU8</accession>
    <name>A0AAV6UGU8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000446">
        <property type="protein sequence ID" value="KAG8182810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGU8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="193" mass="22333" checksum="E57D2789E5776D00" modified="2024-11-27" version="1">MDAEKRAKNNAKQKRYYEKKLNDPNFKEKERLRQKKIRNAKSKIMTKKEKRKQMEAARERQRKCRASKKTKDVMQCSSLNSTVAQEASPYRVPQTLGKAVKKSWNALPCSPRKQKVVVSNLAKKVGLKLQQEKEPSSSGQDIEKSDNELAELVVEFLCRTDIVYTAPGMHDEITIWEDGEKKNVFVNFILQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UI99</accession>
    <name>A0AAV6UI99_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetoacetyl-CoA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_014300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000398">
        <property type="protein sequence ID" value="KAG8183910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UI99"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="3">
        <location>
            <begin position="46"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="109"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8183910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="70364" checksum="376CF2273AAC9579" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJE3</accession>
    <name>A0AAV6UJE3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000374">
        <property type="protein sequence ID" value="KAG8184399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJE3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12280" checksum="BBE38F0EAFA3B5E9" modified="2024-11-27" version="1">MIGPELFVRSEENALKFILRNGLFSIGGSSVTTEIQSSIFHQHSEARHRTLTNRLTPESIPASTPHKEYCVPWSHRRGGDKSNVCGGFQNSILDVPYHSTRTILARSKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UK15</accession>
    <name>A0AAV6UK15_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_002304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000372">
        <property type="protein sequence ID" value="KAG8184457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UK15"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="275"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8184457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="610" mass="68373" checksum="4C4A90B4B6661646" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UM47</accession>
    <name>A0AAV6UM47_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_015476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000361">
        <property type="protein sequence ID" value="KAG8184794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UM47"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8184794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="588" mass="63474" checksum="8DC8D0961B9FA1EB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UM73</accession>
    <name>A0AAV6UM73_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">JTE90_005488</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000338">
        <property type="protein sequence ID" value="KAG8185361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UM73"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07459">
        <property type="entry name" value="CRD_TK_ROR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041775">
        <property type="entry name" value="Ror-like_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00021">
        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 18 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4 20" id="KW-0420">Kringle</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 18 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="39"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="25">
        <location>
            <begin position="172"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="26">
        <location>
            <begin position="333"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="489"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="633"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="637"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="638"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="672"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAG8185361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="869" mass="96821" checksum="2CFCCD7234DC7C6F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNB9</accession>
    <name>A0AAV6UNB9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000327">
        <property type="protein sequence ID" value="KAG8185654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNB9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13159">
        <property type="entry name" value="PTB_LDLRAP-mammal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF74">
        <property type="entry name" value="PTB DOMAIN-CONTAINING ADAPTER PROTEIN CED-6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="1">
        <location>
            <begin position="38"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="288" mass="32068" checksum="0A2C584DFF8815F3" modified="2024-11-27" version="1">MASILKAVRVSSSGLFGRLKHKKLPEEWDDSIKEPVLDGITFYVKYLGSTLVDEPNDQQTTADAIKSVILMAKSSAKKLPRVALTVSPKGILTQDLSTGEKHLDFSIYRISFCSADANYDRVVAFIGTNKNETLECHAFLCSKRKVAQAAALTISQAFNIAFELWERAKEERSKSNAEERIILTVADNKEASECNINNKNSSEPQGALIDLSIDGQSASETMKKLGFENDHNLDDSFSRLAHSRTHPMFGVGWNAADLKDIQQFVNSQRQITQKDCFLDDQLDDLMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNI1</accession>
    <name>A0AAV6UNI1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000344">
        <property type="protein sequence ID" value="KAG8185135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNI1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="84" mass="9203" checksum="73D5374D0EDEF8C6" modified="2024-11-27" version="1">MELRMQGDACSKDLERRPRDDEVSSMMSALSSQDVEDYIHVVRGGEGNCRLEEDEATLPCDHTTPFSSWGFVAVSSLGCCLMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNV5</accession>
    <name>A0AAV6UNV5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000353">
        <property type="protein sequence ID" value="KAG8184936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNV5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="10900" checksum="26F970E693F484FC" modified="2024-11-27" version="1">MSRRHLRTTAQVPDPGLQLLLGHLLVHFLLYKLGRCHLRGFLGYHFILDACCLLILMNVLLPLPLPRSVLLPVTLSRLSPSYDNFRRLLDRSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPH3</accession>
    <name>A0AAV6UPH3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000312">
        <property type="protein sequence ID" value="KAG8186089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPH3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8129" checksum="16DA8D7D47B8A857" modified="2024-11-27" version="1">MTRVKETETRNTCCLKKIPRFTVSLSLRRGSPFDHGKAQTDAPATLFCGKGADPKPTWGGPRHRFTVSPVAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPZ8</accession>
    <name>A0AAV6UPZ8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000298">
        <property type="protein sequence ID" value="KAG8186532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPZ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="159" mass="17907" checksum="3E3E0710FD81F458" modified="2024-11-27" version="1">MDYVLPTLGNIGVQYCFGSMCNIGRYRQQELRNIGQSRLIPIAQCIMDYVLPTLGNIGVQYCFGSMCNIGRYRQQELRNIGQSRLIPIAQCIMDYVLPTLGNIGVQYCFGSMCNIGRYRQQEFRNIGQSRLIPIGQCIIDCILPTLGNIGVQYWAMSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USC4</accession>
    <name>A0AAV6USC4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000309">
        <property type="protein sequence ID" value="KAG8186211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USC4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="111" mass="13055" checksum="BFEFC10502D1D09F" modified="2024-11-27" version="1">MKLLVSSVATCYLYRRKAEATFNFTLAIRMYNGQFKETDENVFDGSNYFKGYSKFLSLEELKGSDGYLDNDTLTVRCRMWKTDFDISASVKWGAHSRIKVSKFDYTWIFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UT21</accession>
    <name>A0AAV6UT21_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Solute carrier family 12 member 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_009483</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000272">
        <property type="protein sequence ID" value="KAG8187405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UT21"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="100"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="597"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8187405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="933" mass="102704" checksum="D06B65AC8F4ED1B9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTR9</accession>
    <name>A0AAV6UTR9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000277">
        <property type="protein sequence ID" value="KAG8187194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTR9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="72" mass="8348" checksum="76FCC5B0ABB0D8EB" modified="2024-11-27" version="1">MDSGERMLTSEIISNLFLFRIPIAKVCAGCERWFKSPPEVYVALNKGEFLLESKKKSHFWPGNECRRARSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTY5</accession>
    <name>A0AAV6UTY5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000277">
        <property type="protein sequence ID" value="KAG8187198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTY5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="127" mass="14587" checksum="6663EC37424BFDA1" modified="2024-11-27" version="1">MAFTNLENLHRKQYIYRKVYKIDNSRSLLLVGEEIPNLSISAPLVGWKAGNFLGLSQEIRFLRMFTGFILVTLGRKWLEKDCLLKQFKHDVCLAQTFMRVIRGKRFGAKAFCLSQPSGVSSRLGEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU07</accession>
    <name>A0AAV6UU07_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_005299</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000252">
        <property type="protein sequence ID" value="KAG8187980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU07"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000030">
        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF5">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE 89DA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="372"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8187980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="555" mass="62873" checksum="6A4AD27F3B54064B" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU71</accession>
    <name>A0AAV6UU71_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_001185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000258">
        <property type="protein sequence ID" value="KAG8187810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU71"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032839">
        <property type="term" value="C:dendrite cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098964">
        <property type="term" value="P:anterograde dendritic transport of messenger ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035418">
        <property type="term" value="P:protein localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19857">
        <property type="entry name" value="DSRM_STAU_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19859">
        <property type="entry name" value="DSRM_STAU_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19860">
        <property type="entry name" value="DSRM_STAU_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19861">
        <property type="entry name" value="DSRM_STAU_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000007">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000013">
        <property type="entry name" value="double-stranded RNA-binding protein Staufen homolog 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051740">
        <property type="entry name" value="DRBM-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032478">
        <property type="entry name" value="Staufen_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054:SF3">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16482">
        <property type="entry name" value="Staufen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="73"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="156"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="280"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="384"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="453"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="676"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8187810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="708" mass="77373" checksum="D976CFD1E39348CE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUC4</accession>
    <name>A0AAV6UUC4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat extensin-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_001229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000258">
        <property type="protein sequence ID" value="KAG8187855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUC4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043843273" description="Leucine-rich repeat extensin-like protein 3" evidence="2">
        <location>
            <begin position="25"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8187855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15616" checksum="6D2211DCD2E47A22" modified="2024-11-27" version="1">MAMSPTKLHLLFFVQISLIWTVFAVYNGPISDPTSCCCSCGCDGKIVYPNAPPEPPQVPPHPPPHKPPPPHHPPPKSLPPPPPPSPHHPSPTFLPPIFPFSTHPPPPGAPPPRGHLPMITLKGCSQHNIHVNRDKVQSSCSHSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UVU4</accession>
    <name>A0AAV6UVU4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000235">
        <property type="protein sequence ID" value="KAG8188610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UVU4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="168" mass="19702" checksum="98709051713751A6" modified="2024-11-27" version="1">MSILVFVRLMSCVYDLLEFLVRHLDRWVLRERPLLAVFLTSLLGHFPQNVIPFAFCCWNKELIYQRREVFLKILVLLCLIVFVIENLFNSRCAFHSPKRHVNLMQVPSQVLESSRITKATQPLYRSGTRSLKPASPDFGYKGLFCIKPSFFASFRTRSRPVSVFEKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWA7</accession>
    <name>A0AAV6UWA7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nodal modulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_005956</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000235">
        <property type="protein sequence ID" value="KAG8188601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWA7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055075">
        <property type="entry name" value="NOMO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055074">
        <property type="entry name" value="NOMO1-3_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055073">
        <property type="entry name" value="NOMO1-like_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056191">
        <property type="entry name" value="NOMO_12th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056189">
        <property type="entry name" value="NOMO_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056190">
        <property type="entry name" value="NOMO_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056319">
        <property type="entry name" value="NOMO_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051417">
        <property type="entry name" value="SDr/BOS_complex"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303:SF14">
        <property type="entry name" value="BOS COMPLEX SUBUNIT NOMO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303">
        <property type="entry name" value="CARBOXYPEPTIDASE REGULATORY REGION-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23141">
        <property type="entry name" value="Ig_NOMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22898">
        <property type="entry name" value="NOMO1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22904">
        <property type="entry name" value="NOMO1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22902">
        <property type="entry name" value="NOMO1-like_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23192">
        <property type="entry name" value="NOMO_12th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23193">
        <property type="entry name" value="NOMO_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23194">
        <property type="entry name" value="NOMO_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49478">
        <property type="entry name" value="Cna protein B-type domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NOMO-like N-terminal beta-sandwich" evidence="8">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO second beta-sandwich" evidence="10">
        <location>
            <begin position="120"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO third transthyretin-like" evidence="13">
        <location>
            <begin position="217"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO fifth transthyretin-like" evidence="14">
        <location>
            <begin position="400"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO seventh transthyretin-like" evidence="11">
        <location>
            <begin position="578"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO-like ninth beta-sandwich" evidence="9">
        <location>
            <begin position="741"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO C-terminal transthyretin-like" evidence="12">
        <location>
            <begin position="1001"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8188601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1170" mass="130120" checksum="426056DD59DAD31C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXL1</accession>
    <name>A0AAV6UXL1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KH homology domain-containing protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Brings lots of money 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_007175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHDC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000236">
        <property type="protein sequence ID" value="KAG8188568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXL1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22385">
        <property type="entry name" value="KH-I_KHDC4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047890">
        <property type="entry name" value="KHDC4_KH-I_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase PRP5/DDX46/KHDC4 KH" evidence="7">
        <location>
            <begin position="87"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="KHDC4/BBP-like KH-domain type I" evidence="6">
        <location>
            <begin position="226"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8188568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="630" mass="68394" checksum="42B171E2591A834E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYZ8</accession>
    <name>A0AAV6UYZ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000227">
        <property type="protein sequence ID" value="KAG8188889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYZ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="20083" checksum="C0C05AE2C4694C30" modified="2024-11-27" version="1">MNSCEYSIFHSSARLYRSPTPAKTHLDFLTYIPTTYLRLPLPPFPLKPRVSNPTPVPQYNEKIRIFDIWKTVYLFDGGRCLLGGIHALFIILCSLSWFRFSFRFVLSFFSAVFDGEFASPPTRKEWARPRLDGRLVTSQVMGGEGWVTSRRKAGVSVFFFRIHVKRVFENWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZH3</accession>
    <name>A0AAV6UZH3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxisomal multifunctional enzyme type 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_003928</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000233">
        <property type="protein sequence ID" value="KAG8188671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZH3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000013">
        <property type="entry name" value="Peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000185">
        <property type="entry name" value="peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="11">
        <location>
            <begin position="13"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8188671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1123" mass="122964" checksum="13A237F0F4836E48" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0H8</accession>
    <name>A0AAV6V0H8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proton-coupled folate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_018134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000214">
        <property type="protein sequence ID" value="KAG8189482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V0H8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8189482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59213" checksum="187FC2E47BAA24E5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1T9</accession>
    <name>A0AAV6V1T9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_024870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000175">
        <property type="protein sequence ID" value="KAG8190737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1T9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000002">
        <property type="entry name" value="Cyclic nucleotide gated channel alpha 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF4">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="196"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8190737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="398" mass="44006" checksum="4B6CB9A66411B065" modified="2024-11-27" version="1">MLLAIAINVHLDTLKRVDIFHKTESGLLCELVLRLRHVLFSPGDYICRKGEVGKEMYIVNCGRLQVVAEDGRSVLATLRAGSYFGEISILNMGSAGNRRTASVRSLGYSDLFCLCKKDMWEVLKDYPAARVRLEAIAVKRLHKYKKEPLRKIAMGRCRSTPGLVESVGKIRIEDMVVGMTTSSAFPTAAIFDDHTINDNPSSSLNERRSTDSSNNTQYGDLAGGIPLEPLNPHSDNNNRVPRRFSTGPLVGTNGLNHRLPPPGKAAAADIKQTSSFLSLHSGSTITRPVSPYQNDAILLDNNQTNLFPFTRRSETQESLLEEIRKLRTKVLDLEAENASMSLKLSQSKWEMQNRITDLELQMCNNPLAMVGAPIVVPRPTSSGSGSGEDLERNRESII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V5F0</accession>
    <name>A0AAV6V5F0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_007750</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000149">
        <property type="protein sequence ID" value="KAG8191955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V5F0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000301">
        <property type="entry name" value="Serine/threonine-protein kinase Chk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000229">
        <property type="entry name" value="Serine/threonine-protein kinase Chk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF107">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="10"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8191955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="469" mass="53551" checksum="5D9AD6DFCA444E4C" modified="2024-11-27" version="1">MKGTQFVEGWNVVQVLGEGAYGEVQLVINCSTQEAVAVKHLDTRKEATAANNIQKEVFIHRRLKHEHVIKYFGHREEGHIHYIFLEYASGGELFDRIEPDVGMPHHKAQKYFLQILKGVEYLHSAGVAHRDLKPENILLDDNDNVKISDFGLATIFRHKGKERILQNRCGTLPYIAPEVFFRKYKAEPADLWSCGILLVVMLGGELPWNEATLDCIEFALWKDSNYSVSPWTKIDNLALSLLTKLLSYSPSKRYTIKDVEHHLWCKKDFVPEGPERWTGENTSHKRLCSDLEQPCVLREDSVTKMSYSQPAPNFVYVDNNDSLPRNISGDYVGPSFSQPVDPDNMILASQFSASQMMSKSNLPIGTRLTRFCIGMDIGAVYGELIRAFEKLSYSWKHSGPGQVTITCQDRRKMHLIFKANLISMPEKVLVDFRRSRGDGIEFKRHFLKIKESLKQIIDREPFSGSLCNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6L7</accession>
    <name>A0AAV6V6L7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6L7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16169" checksum="D4A061DED36D8D8C" modified="2024-11-27" version="1">MVDRDRERDAEERCPMGEERRGGGYAIVVAQAADRKIKLFGCPSGRFEGESGSDEIWEVNGRLLESWTVREVRHFLQRCVHSRTLCLRIKPDKCREKGPKSINLISPKVVFEKCFPPEIFNSSTISNKPGGAYKVVKNIWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6Y0</accession>
    <name>A0AAV6V6Y0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000156">
        <property type="protein sequence ID" value="KAG8191623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6Y0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8643" checksum="71F88464DD017832" modified="2024-11-27" version="1">MSAVTCHAYLAIKSPDTSATPEHPRWKLWQVPKYNRKDGFERRISHKPEYYGTCAVWLNARNQFWIGSCETAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V733</accession>
    <name>A0AAV6V733_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Histone-lysine N-methyltransferase EHMT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_001738</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000147">
        <property type="protein sequence ID" value="KAG8192002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046974">
        <property type="term" value="F:histone H3K9 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20905">
        <property type="entry name" value="EHMT_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10543">
        <property type="entry name" value="SET_EHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000005">
        <property type="entry name" value="Euchromatic histone-lysine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043550">
        <property type="entry name" value="EHMT1/EHMT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047762">
        <property type="entry name" value="EHMT_CRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307">
        <property type="entry name" value="G9A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307:SF4">
        <property type="entry name" value="G9A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21533">
        <property type="entry name" value="EHMT1-2_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="12" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="13" id="KW-1053">Target membrane</keyword>
    <keyword evidence="9" id="KW-0800">Toxin</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="788"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="821"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="854"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="888"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="921"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="954"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="17">
        <location>
            <begin position="1077"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="1144"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8192002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1351" mass="149715" checksum="C4AE844F57A42F83" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V759</accession>
    <name>A0AAV6V759_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_021173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000157">
        <property type="protein sequence ID" value="KAG8191568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V759"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8191568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="192" mass="22196" checksum="4A3BCA6AB401D000" modified="2024-11-27" version="1">MKSRKRNPLISYVISNSRQHQQTSSNLSNFKTSNSKTLQKTPRIFNTHKRIEKNTPQHFFSKRNIPRITKVLQTNGENPRKNRPLSLSNSKGCYHKRSARAVHRLPLAIPPLVRMRGTACARVESGRHVMRNIQSGASTLTSRSESEIKKLYRGVFGNMWKGIAEFIAVHIGGLVWYWCNLQFNEFDAFKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V774</accession>
    <name>A0AAV6V774_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetyl-CoA hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_026819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000152">
        <property type="protein sequence ID" value="KAG8191784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V774"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432:SF20">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432">
        <property type="entry name" value="ACETYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="3">
        <location>
            <begin position="46"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="4">
        <location>
            <begin position="311"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8191784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="51621" checksum="55FC3C3D2847AAA8" modified="2024-11-27" version="1">MASRCYLSSRQILNFFKNRNSIKSSSRKFHENLREPSQPLGNKQAKWMSAEEAVKVVKSGDTVFVQGAAATPRVLVPALAEHGKKAGLKNVTVCHIHTEGAAEYNKPELEGIFRSNSFFVGANSREAINSGRGDFVPVFLSEIPLIFHKKILPVDVALVQVTPADNHGYCSLGTSVDCTRAALQHAKYVIGQVNPRLPRTFGDATIHVSHFDALVEGERELPEHKADVLTDVELAIGKQIAEKLVADGATLQMGIGSIPDAVLASLKGHKDLGIHSEMFSDGVVDLVNLGCINNKYKAVYQGKIVGSFCIGTRKLFDFMDNNPFVVMLNVDYVNHTDNIAINPKMTAINSCIEVDLTGQVCSDSIGTRIYSGVGGQIDFLRGAGMGKDGLGKPILAMPSTTSKGESKIVPFIKQGGGVVTSRSHIHYLVTEHGIASLFGQNIRQRAYHLIQVAHPKHREALEKAAFERLKCMPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7P9</accession>
    <name>A0AAV6V7P9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000154">
        <property type="protein sequence ID" value="KAG8191681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7P9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="11365" checksum="8189C7AEE3239519" modified="2024-11-27" version="1">MISAQVVSWMEWEIGVGLSSPKFVYCGRDVNFRNRRKVGGCHSNQLPLEIGKWYSLMVVFPASIAGYHINDSMFVIRSALIQHVAILNERDFSCSIKRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9W9</accession>
    <name>A0AAV6V9W9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_017961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000139">
        <property type="protein sequence ID" value="KAG8192431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9W9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="92"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8192431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="402" mass="44952" checksum="1DADDF7F3A6EF5E1" modified="2024-11-27" version="1">MRYAGQSPPEIFRRIETLCYGIWHRDYPMHSPHVSNQQQDSFDANHTDLSHCYMEEPIGVKTNLIDAFDNANTPTKSCSRGKQNTSLLSSEALICVTLWYFFSFTTLFLNKYILSYEQGDPALLGSAQLLMCCICGYMHLKFPCGLYNSIKWDRNPPRFFRNMLLVGSLRFSTLILGLVALWYVPVSFAETVKSSAPVFTVFLAWLLMSEKTSWLVCMSLLPIMGGLALCSANELSFNAAGFVAAMSTNLSECLQNVYSKKLISGEKYCYSPPELQFYTSLASVCVQIPTLILMIDVSLIRTNFTYHMLLLLVINGVSFHCQSITEYSLLSYISPVTHSVANTVKRALLIWLSVITFGNKVTFLGGLGTAIVIFGVCGYNKAKEIAPTVHLPLKGEKEVHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VA52</accession>
    <name>A0AAV6VA52_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_023726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000120">
        <property type="protein sequence ID" value="KAG8193474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VA52"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001329">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="223" mass="25291" checksum="B54323B19D63DE13" modified="2024-11-27" version="1">MAAEEFKVILVGESGVGKTSFVVRLAESKFQNVYESTVGVDCKKVRVDVEGTPVDLHIWDTAGQERFKSIINRFFRSSDGAIVMYDVTKQLTFDEVPWWLKETREHLTGIPIFLVGNKNDDASQPEVLEELAQDLAEENRLYLYQTSARDNVKVTEVFQDLAAMMLADRKKAQEEADETPNLYERSDDANLDVRKILLKTDSQKPKKSCCSYFASPDTKAHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAE9</accession>
    <name>A0AAV6VAE9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tetratricopeptide repeat protein 5 OB fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_000216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000118">
        <property type="protein sequence ID" value="KAG8193579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAE9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032076">
        <property type="entry name" value="TTC5_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038645">
        <property type="entry name" value="TTC5_OB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16669">
        <property type="entry name" value="TTC5_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 5 OB fold" evidence="2">
        <location>
            <begin position="306"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="427" mass="49017" checksum="C3FDBDDB587933EA" modified="2024-11-27" version="1">MSIQEHVDKLYLFRDHYFDNHKPESAEQKIEDLRLELSKTLNLLDDTGDASTASDKVQRELMKARALNVLPDFNPEALEILTKLVKFHPKLVQAWNELGLCFWKKGDMKAAKSCFESALREEKNAESLRNLSMILRQLGQSPEEKLSKMHESLDKAREAVNLNIQDGKSWYVLGNAYLSLYFTTDQDPNLLKQCLSSYNQAFTDDSVKCNPDLYYNWAMALKYDESYRTAIENMEKALKYDPLWTEAKEQLDSLVKHLENIQLMITKKGKIKARRIKDMLSSLKKEHDGCSIDEKFVNKEGKPVILQRCKFAELQVGLNVGKLLRGKVVCHVYYTDSPAFTFCMIDDDENCFAVNVYNMVQGKGVIIGDSVAIFQPFVQHFNFTYKEKAFSFSSVRVNNPLQLEVNKKKLGSEVMAPPRLSVTLKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEL1</accession>
    <name>A0AAV6VEL1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000091">
        <property type="protein sequence ID" value="KAG8195240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEL1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="182" mass="20371" checksum="E540B19C0B1021B9" modified="2024-11-27" version="1">MSKQSGGGGEGTIGGVSSSPAEEDKNNRRGKATHSKVDIHQHKTAQEATIHHSFLFPLSFPRDARHRGVLFEDKRAQLLSIPIQGCHLLHLADRSVVAWRKVYPPFDGPASSKVSREWFMVACLPLLISNESLSPLQKTGMFEARMNVTQLVYVYPKQPGEEESRKKMHHPVPDEEVPLRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEU0</accession>
    <name>A0AAV6VEU0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide-binding protein subunit beta-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_013270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000102">
        <property type="protein sequence ID" value="KAG8194518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEU0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="196"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8194518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36504" checksum="40A6473CC3BECD44" modified="2024-11-27" version="1">MPRQPPPPYFVLRGHKGLVSALHFTIELYHQGFQQPALISGSDVGEIFIWDLKSNRTSHRLNGHENKTIMSLHCYKYSLISQGRDGVINIWNNIQDQWTVIRRIHSTSTSVGFCASSLISVENSVHLMLPNEDKNSLKIHDISGSQVRSIKFRTEFGMCMCIKAFNMNDKTLLLAGFENGCIGMWDYETEKELCHIKCHKELVTCLDFDSNYSNMGISGSVDTSLQVWSLSEKLELIEVKTIEVVNKGINAVKIRDDRKIVITAGLDCKVRVFSWKTLQPLAVLQFHELSVHSLACCPVSVGDHRSVFASGSKDQNIALWEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF66</accession>
    <name>A0AAV6VF66_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitinyl hydrolase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000101">
        <property type="protein sequence ID" value="KAG8194638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VF66"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16565" checksum="220591DBFD3F6136" modified="2024-11-27" version="1">MQWVYAVPWLFCWVKAIHDSMSLYLPTLKKKTCDVLMRRAMKLHADTEVAEGGLAALRIFEFLNVFLDVQVIVISSKELQKISYKGSERPQKVYLWLHKGHYDLITSLKGFYGRLVMSTVVDWSKSAINLDITSKLSRSSYSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFB0</accession>
    <name>A0AAV6VFB0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000103">
        <property type="protein sequence ID" value="KAG8194401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFB0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099044">
        <property type="term" value="P:vesicle tethering to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000799">
        <property type="entry name" value="StAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051869">
        <property type="entry name" value="STARD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121:SF4">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00978">
        <property type="entry name" value="STARPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="57"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="239" mass="28115" checksum="BB325736C2AA7C3F" modified="2024-11-27" version="1">MLLFKLFDCISLLTTDDTLHRWMVQFAVHHHHTSSKKKDNFTELADKGLYESLKLIDGSGWKEESKNEKDVLYSKNIPEIGKVFKYEGIVEVDAETINDKLYYNIERSPEWNNSVDKVDVIQTVDNQTNIVRIITRNRFFVSSREFVHLRKWKKVGDSFVHSTFSIDHPEVPSDLSFTRGEHRFCTYVIQPLKEDPSKTRLVWLMQVNLKGWLPQQIIDQAVSFGMESHFEDIRTFRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VFF3</accession>
    <name>A0AAV6VFF3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ectonucleoside triphosphate diphosphohydrolase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_002626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000087">
        <property type="protein sequence ID" value="KAG8195454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VFF3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="270"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8195454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="58247" checksum="572CB4A1ABD93337" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGG9</accession>
    <name>A0AAV6VGG9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat domain phosphoinositide-interacting protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">WD repeat-containing protein 45B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_023339</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000092">
        <property type="protein sequence ID" value="KAG8195163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGG9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000083">
        <property type="entry name" value="WD repeat domain phosphoinositide-interacting protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8195163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="356" mass="39246" checksum="44256F21110264DF" modified="2024-11-27" version="1">MNLGPTNPYGNSLLFAGFNQDQGCFACGMENGFRVYNCDPLKEKEKRDFSDGGIGYVEMLFRCNYLALVGGGKKPRYPPNKVMVWDDSSEKHVIELDFTSDVKAVKLRRDRIVVVLETMIKVYTFTQNAQLLHIFETCSNPKGLCVLCPNSNNSLLAFPGCKSGHVHIVDLANTEKAPLDIAAHEAPLSCIALNLVGTIIATASEKGTLIRIFDTTSGNLLNELRRGTNQANIYCINFNFDSSLICVSSDHGTVHIFAVEDSKKNKQSSLASATFLPKYFSSVWSFSRFQVPGGSHCICAFGTESNSVIAICADGSYYKFLFNPKGECTRDIYAQFLELSDDSSSIMDIYGKNRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNB0</accession>
    <name>A0AAV6VNB0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000057">
        <property type="protein sequence ID" value="KAG8197297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNB0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF53">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="1">
        <location>
            <begin position="244"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="372" mass="42401" checksum="83CE18E702DF69C9" modified="2024-11-27" version="1">MSIIPPRPSNIFSSSNRRRQFQTGIQRQQSFSLDIPQNIYDNDKLSRGLDSFYAEEPLRSRDEDRVFLFLPRNLSYCEVCSDVIRDHVQKKVRLLSSRLCQYDDVPPTPVENKAIFSVGEESGDEDTEETLVDRPKDAFQTWCADKHGHTSVDTCFPKRPILKRKVRAVSFPAPRKEGKKIVRFADALGLELESIRFLVQKDLPKLVPSCSELDVSTKPKAKNGNQKIQLIPAFLPPSLNNSFIGHLRKLNVCLHSVSTADSTVYGIISVINKSFHKTVFVRYTANGWMSYHDELATYLDGSSDDDTDKFTFTLFCNPSDLCTRGHSLFFAVCYETPGGVQYWDNNNGKNYCIKCEKREIPVVGNHSWVHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPP4</accession>
    <name>A0AAV6VPP4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPP4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8972" checksum="3B4B038CEED90327" modified="2024-11-27" version="1">MLFRYQCTGREKRAAEQHSQLKESMKGLENQQMELQKEVEETKNVLERCDRLFKQTVQQEKLTAKKLKEKKRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQR9</accession>
    <name>A0AAV6VQR9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_001775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000033">
        <property type="protein sequence ID" value="KAG8198975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQR9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000054">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8198975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="141" mass="15583" checksum="C162166AECA09E84" modified="2024-11-27" version="1">MATLCVRMETREILLWESITGRKFIELTGGQMSRKLKQLSGIPILSNSRCNQAFTAEAVSFRSDFPRGINQGFVCAGFLEEEGRDSCGGDSGGPLMYQDGSQWYAVGVVSFGYSCARRGLPGGYTRVSEYVDWINSNRNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSY0</accession>
    <name>A0AAV6VSY0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Caspase activity and apoptosis inhibitor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000028">
        <property type="protein sequence ID" value="KAG8199348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSY0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038991">
        <property type="entry name" value="CAAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14740">
        <property type="entry name" value="CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14740:SF3">
        <property type="entry name" value="CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15335">
        <property type="entry name" value="CAAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="28014" checksum="1C70AB6E25CFD313" modified="2024-11-27" version="1">MHQVEPKKKQKEMKKSKSSSKDKRKISSSVDSSKKRAKTVEKEHEDKNPRKSRWEKKNPEDEIEKSAPFTEEAASNPEPPRRLKDMLGDKKKIIEYLFLTVTVPTLQELIPDYLKNRSIEELKNLCFAEIKEMSNEHILDLISGAESKETNENQEIECSPKQPSVASESVSSDLLELCASANDMKGLNDDSDNENSNQEDQENLEFSRVIESEADLMELEMRARAIRSLLKAKSQELPDSDESGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTZ3</accession>
    <name>A0AAV6VTZ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000024">
        <property type="protein sequence ID" value="KAG8199768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTZ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="155" mass="16684" checksum="C24FF974AA0D062E" modified="2024-11-27" version="1">MILSTLLESGSLLSKSPLSNKNCKSAPLTSLYFVHGLGHYVESWLAPRSTQRVSLPSKCPPQQQEVQPLLPAAHMHWPPPLQQVGNGGGKYIFMALGTAKGLLFAFQVPSATMSTASANRSSQKKVAGDARSGKLGKRGTSERKEKKQQCSTHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVS6</accession>
    <name>A0AAV6VVS6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="9">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_015756</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="9"/>
    <dbReference type="EMBL" id="JAFNEN010000012">
        <property type="protein sequence ID" value="KAG8200849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVS6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06615">
        <property type="entry name" value="PKc_MEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000115">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000100">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="81"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8200849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="409" mass="45025" checksum="050759E93B216F8B" modified="2024-11-27" version="1">MSKNFGKNKLNLKLPPGAIEVNNSEPPGNVDPNNDKSMLSTSFEALQKSLEGLDIDDQQRQRLENFLTQKQQVGELAAEDLQNLGELGAGNGGVVTKNLHGPSGLIMARKLIHLEVKPAIRNQIIRELKVLHECNSPHIVGFYGAFYSDGEINICMEYMDGGSLDLVLKKAGRIPEPILGKVTIAVLKGLNYLREKHQIMHRDVKPSNILVNSRGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYTVQSDIWSLGLSLVEMAIGRYPIPPPEPKELAAVFGPKYSASADQSESPSPSSKNRPSSFYLPYGDGPRIMSIFELLDYIVNEPPPSVPSSVFSPEFKDLVDRCLKKNPAERADLKFLTTHAFVKRSDTEDVDFAGWVCKTMGLDPSTPTKISPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VX69</accession>
    <name>A0AAV6VX69_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homothorax</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_002703</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/MEIS homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000009">
        <property type="protein sequence ID" value="KAG8201025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VX69"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048663">
        <property type="term" value="P:neuron fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000004">
        <property type="entry name" value="Meis2 homeobox isoform 2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032453">
        <property type="entry name" value="PKNOX/Meis_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16493">
        <property type="entry name" value="Meis_PKNOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEIS N-terminal" evidence="8">
        <location>
            <begin position="74"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="KN homeodomain" evidence="7">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8201025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="45183" checksum="0A4BF934D604963B" modified="2024-11-27" version="1">MKSEPYPVEHPLAMQYEDGMPHYGGMDGPMYDHRAMQQLSHAPHMNHTPSMHQYHGNHSGVMSNHIMGSVPDVHKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGIAGGDVCSSESFNEDIAVFAKQILAENPQYSSDDELDTLMVQAIQVLRFHLLELEKVHELCDNFCQRYISCLKGKMPIDLVIDERDSKPGDLGDNNNNSSNGGGGAGGGGNGGAGGGRGNPDATGHSSDNSSTPDQSFLPYQRPPSQSLNSYSTGPDDARSPTGSTGTPGPISQQPSSQMSTDNNSEAGDASIGDGSGTGEDDDDDRSKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNCMEILCAEPGPEKLHVLPSVIGGFERQLLHQTSDTVTDQQSLIFFLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZE9</accession>
    <name>A0AAV6VZE9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZE9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8201835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8325" checksum="9756B4C95F38E16C" modified="2024-11-27" version="1">MHDFMSQNFQGTVKQEASSFLSTAIGYIGKEIMELSVNAAITRLGKGKDVKVTLEDVQTAINSDEDLKKLMDDSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZP3</accession>
    <name>A0AAV6VZP3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_010449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000001">
        <property type="protein sequence ID" value="KAG8202087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZP3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000082">
        <property type="entry name" value="Leucine-rich repeat-containing 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043966972" description="Ig-like domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="260"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8202087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="680" mass="76853" checksum="FE9B142024777C61" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W0B0</accession>
    <name>A0AAV6W0B0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_011188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000004">
        <property type="protein sequence ID" value="KAG8201512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W0B0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03887">
        <property type="entry name" value="M20_Acy1L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="175"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8201512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="403" mass="43716" checksum="62EF92115B696DCC" modified="2024-11-27" version="1">MAESLFKVVNANVDREASLLNKVSQLIWNNPELKYEEKFAHDLLSSTLETKGFTVQKNYVLPTAFRAEFDSGKPGPVVVTICEYDALPQIGHACGHNLIAEAGLGAGLAIKAAMEAFPDIPGKVVVLGTPAEEGGGGKVVLINAGAFKDVDAALMVHPSPNDHLYPPFIAIERVIIEFFGKEAHASGYPWEGVNALDAAVNCYNGLSQLRQHIKPTCRVHAIITKGGEMPNIIPGYSKMDLYYRAATTYDMECLRKRIDAIVKASAESTGCEFKIEKGDGYGYKSLMTNKVLAEKYRKYAESLGAHFDDSNHKIIPFMASSDMGDVSHVVPSIHPTYSIGTTAANHSVDFADASATPEAQVTTLITAKSMALLALDVLRDKDFLDQTKKDFEKDVAEDAGLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6W225</accession>
    <name>A0AAV6W225_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homolog subfamily B member 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Endoplasmic reticulum DNA J domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_011230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with HSPA5/BiP; interaction is direct. Interacts with ERN1/IRE1 (via the luminal region). Interacts with DERL1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000004">
        <property type="protein sequence ID" value="KAG8201556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6W225"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="51"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8201556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="245" mass="28683" checksum="E6689E6CD930FC82" modified="2024-11-27" version="1">MTFLVKYKSKNNPPYHLYNDFQISQTLRMNLNILVPFVSCVLWTIVSCQEDFYNILGVKKNASNKDIKKAFRKLAMQYHPDKNKDPKAEEKFRQIAEAYEVLSDEEKRKEYDRFGRSGFQERHGHHGSNFDFHSFFDKFDSFSNFRSQRNGHHKAERFNFHFGGDNFFNFDDLFSDFDADESFGSFDEDDFFGSQDSFFGSHFGGNEDGRNIRSHRESFSSSSSGRCRTVTQKIGNMVSTYTQCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCP0</accession>
    <name>A0AAV6TCP0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010007527">
        <property type="protein sequence ID" value="KAG8155655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCP0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="143" mass="16495" checksum="61D72DF42691CAF5" modified="2024-11-27" version="1">MCKNFFGVSKKQDPAKNLPLVTPPSQFFRFSHINVDGWVLYPKFPWILLRFPTRGDRFSPGRKAPFPHGRPDCCDRRRNILRRFWVSRFWSFPPGASLPTRGDPSSLISAMPPDEVPGDRKKTPKKPPTTRLLTEKVEDFIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TF04</accession>
    <name>A0AAV6TF04_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005544">
        <property type="protein sequence ID" value="KAG8170398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TF04"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10393" checksum="4093EE12C2D803AC" modified="2024-11-27" version="1" fragment="single">MLVKFATQGIDQFLLVGASKTSKLALVSQWWNRPNLPSFSVRVKSGTCAPKHQLTICQCPSVLFKGEVSLVVGNMLRIYDIGKKKLLRKCENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFV1</accession>
    <name>A0AAV6TFV1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Recombination activating protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005038">
        <property type="protein sequence ID" value="KAG8170684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFV1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14143" checksum="AC730BC51532097D" modified="2024-11-27" version="1" fragment="single">MNQFRCELGIIGNKVDSYRFACVNSGLTVLQPPQCEEIEDHELAAIQGCSIFIAGVNHSYNSIHGCESRDSVNDKKYKMLEEDSLVSTAGLTVLQPPQCEEIEDHELAAIQGCSIFIAGVNHSYNSIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIM6</accession>
    <name>A0AAV6TIM6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003774">
        <property type="protein sequence ID" value="KAG8171599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIM6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="330" mass="38321" checksum="B5BBF24805BC87E8" modified="2024-11-27" version="1">MSTSSSCDKPVQDIEGLVQVITSKVFRDHPYLWASHKLVLQRVCTYASEAYQEFLFGCVPWVTDIKCIQDLELDVQEIEHLKTIRQSLSRSLEEKTLMDHIIDQLDKDGTCTITGHDCIGRMHAEICSRCRCVQVFAVDGFFWERHYTICRCLQHDDYRKLHAKAVRKMYVMNITTSPEETKQVLETIFREEWHKSQGLVCRYCREVLTNVSRIHPIFRNQQQKLNSLSDYRKPCSSQAASRGSKSPDKCMNAISNWDEISSQLLKQMDENSCESSLHVLIEMVAETYQRMCLAVVLSSLFIHQQVLSIESRVDVRVGDDDDKTYGFYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJA6</accession>
    <name>A0AAV6TJA6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003348">
        <property type="protein sequence ID" value="KAG8171949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJA6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12237" checksum="1814CDDBF6CC92EC" modified="2024-11-27" version="1">MEQVLPAAAGTLLLPSNCVRGKQQGVERTNKRVSGHAARLQLTPTPAARCYDHNMHHIPNRNNFRDGAARQRAGHTRREAETREAARLADTVIHQLNPRAKTLCPIYKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TK45</accession>
    <name>A0AAV6TK45_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003159">
        <property type="protein sequence ID" value="KAG8172071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TK45"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8172" checksum="727709B9F88B7E63" modified="2024-11-27" version="1">MRKVSESVNPDIYSPSSSQNGDSFPRTFPPSVTGHHRQFDGLTAGRNYEYQSSPPLRFYGRVLAVSGLLGELLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TK78</accession>
    <name>A0AAV6TK78_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003357">
        <property type="protein sequence ID" value="KAG8171941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TK78"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11062" checksum="E8D60FF4D7F5EACB" modified="2024-11-27" version="1">MPWSIRNIDAIYERPDSHIVVFTGQNYWIHHGNGFTSDSPMPLTSLGLPSELERLDAAFVGPKTDGRTSSVEITIGGSTRQRLRWTLDIHKVSLRGGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TLK0</accession>
    <name>A0AAV6TLK0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002408">
        <property type="protein sequence ID" value="KAG8172759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TLK0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="187" mass="20743" checksum="F952EC6F813916CC" modified="2024-11-27" version="1">MDLRVNDLGLGAPMKGYPAWPAPHLGTPKKGHKPLPLFVLLGKNNYAWSGMNISASFEENRGCCSAKKYLGWFFKGEIALQIKYFFSILGGIVRRLPGDRPPRDGGNRFPGAVRTRIGATWCTSQRPCPADVIAACDLTFLLAWRARSASKASSSPRRRPQGNWRGHAKAGSPDNGRHFKYLNFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TR76</accession>
    <name>A0AAV6TR76_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001293">
        <property type="protein sequence ID" value="KAG8174194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TR76"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="193" mass="21375" checksum="78D5F45D5AD0EBAB" modified="2024-11-27" version="1">MRLKRLESIKRSLSDHASDSFSLDFLISTVLSTLLFRVRRNLTGVASYLPASMGSAFMSLPLLLVSTIGSREGVSSCQAVTLYKPSNFASIACPAASAVLVVYHRTHGHRIKRHNAVVSCVARGLEERHFTVHQEHRFSSSRGILKPDLLAIKDGKAFILDAQVISDGEPQGRAHRRKLDKYTELYSFCLCDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TS34</accession>
    <name>A0AAV6TS34_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prolow-density lipoprotein receptor-related protein 1-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_006652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001201">
        <property type="protein sequence ID" value="KAG8174494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TS34"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032485">
        <property type="entry name" value="LRP1-like_beta_prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16472">
        <property type="entry name" value="DUF5050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Prolow-density lipoprotein receptor-related protein 1-like beta-propeller" evidence="9">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="6">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8174494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="303" mass="33436" checksum="4F05AACF0B1CDD4B" modified="2024-11-27" version="1">MVRTVLQEGGIKPFAIVLHPAEGFMFWSDHGVPKKIERCNMDGTKRKVIAKEDIDYVKSLAIDLDSQRVFWVEYSKNYLSSAKFDGNNRRKNLITQLKTSTSIDIYGQHVYFVTYETGHKAVYKASKVDGSGWTKVFDGKNTLYKLKVFHPSKQLEGYDVCGDDNGGCSHLCLPTSGHTFSCACPNDRDMSSDNFTCLNSDGSVVTSTPRLTTNAPSSRLPFTIPQTNSTSGTKENKNADATVGSSCTHGTLAVVIASVTFIAMVGMLIYNRHLLTRIVASAGNSNPVQRRNCEENMYTEAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSG7</accession>
    <name>A0AAV6TSG7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PiggyBac transposable element-derived protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_024384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001233">
        <property type="protein sequence ID" value="KAG8174380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSG7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032718">
        <property type="entry name" value="PGBD4_Znf_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13842">
        <property type="entry name" value="zf-Tnp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="3">
        <location>
            <begin position="67"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein 4 C-terminal zinc-finger" evidence="2">
        <location>
            <begin position="478"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8174380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="63045" checksum="5B84476328C8FCE3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSJ4</accession>
    <name>A0AAV6TSJ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_024898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001089">
        <property type="protein sequence ID" value="KAG8175032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSJ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043742306" description="Carboxylesterase type B domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="34"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8175032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="490" mass="53437" checksum="2BA53388D633D579" modified="2024-11-27" version="1">MALPIKAAVLIQAIFAFLCVHQSNAGLVKLGKVTLDTPVGKVRGKSLLLTDNSQYNTASSFYEFLGIPYAKPPVGKLRFKPTEQPEPWKGTYDALVMPPACPQYAENPFPWYDTLPGQSEDCLYLNVWTPKEAVLGYNDGDETKKRAVKLYIHGGGWFTGGSSRMGYYEGYGEANDFDITDNLYKEFTGLVMVTVNYRLGALGFLSSGTDDAPGNAGLQDILTALKWVHSNIASFGGDPNNIVLFGQGAGAIAASLFLTVPSALPLFNKLVISGATLYTLKALKGVTNEYGDGSDNNIKLANRLAEAVGCGGSIAKNPKDTVDCLKGVESSRLVQTLASFSPVFQQPPNVFLPQFGRDDLIPLGDPFAILDGRFNYYDKKDAFLAYTTDEGSYLLTVNNPDVFGVFGEKDTGIDDVQAKSMMTKFLENFPQPDVLAEKLLGDLDTKPTVGNRKRVYQVMGHVNTICPIVYLADDLVKDDRHTVFVEEKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSS1</accession>
    <name>A0AAV6TSS1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001136">
        <property type="protein sequence ID" value="KAG8174803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSS1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="409" mass="46782" checksum="101C96C3A0562456" modified="2024-11-27" version="1">MGKNYKVLNAWFQKKDGTGQLYSSWCKKVSEDEVLCFVCNKRIACAAKGWAALTQHETTNCHKNAISIKLSQSQLLLKPRVSIQDSSPVIKPIELCHSREEAAKAELIWALKLVKGNIATSFADDTTKVFETMFGTIPTGFSLGRTKFSYLITEALGPHFRDELLLAARKSWEDFELAQEKKAVPQHTFLKHVSSRWLTAGPACERLLEQWEAVKEYFLVFVPNRDKKIMKSTKYKRITSTLKETGILVEANFVIESFDVFGKFVVLFQSSHPLVHEEQKKIKEQKEKEKLQKEDELKKEKEMSEKLENKKQSIDKLESKVKAVALEKKEVRESALCLLKEANKSLKDAISKNDLKAVRVAQGMLEGAEKLREQEKSHEEQEAKLNKIVNKRKKSIIDAFINKKPKLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TW57</accession>
    <name>A0AAV6TW57_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000944">
        <property type="protein sequence ID" value="KAG8175878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TW57"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8175878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="8440" checksum="99D05171BBF9D8D1" modified="2024-11-27" version="1">MSGAVQRWRTFFHNFAPVIIMVPGLVIAHWVWFRLQENPAFVPRDKWESHPLKKKKDDLVAFFSRSSNKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWF3</accession>
    <name>A0AAV6TWF3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000918">
        <property type="protein sequence ID" value="KAG8176069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWF3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="13722" checksum="9D582D558AF9BD9D" modified="2024-11-27" version="1">MGRKRKSSTLKSNQMREKRAKTVEVSVCLDGSEVITSPTGEKVVERRRETLSKLPTPSKDSTIETSDEFFIIGKDKLKEIIGNCSCSTCGGNLNINFENINGFASDIVLFCLNCNFRTTTSSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWZ3</accession>
    <name>A0AAV6TWZ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000894">
        <property type="protein sequence ID" value="KAG8176333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWZ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="336" mass="35066" checksum="D149D44C531157D7" modified="2024-11-27" version="1">MKSVRCRWTIRKKWIRKSIRWKWTTRRGYGNPLDIPPGQGYGSPLGGSGPSGGSGSPLSGSGPSGGGSGNPLGGVGPSGGGSGNPLDGSGPPGLAYGNLVGGSGPPGGGYGNPLSGSGPPGGYGNPLSGSGPSGGGYGNPLSGSGLSGGGSGNPLGGVGPSEEDLEIHWWKWTTRISIWKSSRGKWTARRRIWKSLGKSGILEGDGSLDSSGGSEPLRGGGYEDPFDGTGPLGKSRKESHMVKMVHRRKRSSERKRIFGHIIKATEPPLPDRDLSFLKSLIQQLQEQSQATSTSCRWKSSYCDDCSWHIFSNTCAENYAASDLLWVERQGILEKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYN9</accession>
    <name>A0AAV6TYN9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-latrotoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_000479</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Homotetramer in membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cationic peptide 01 (latrotoxin) family. 03 (alpha-latrotoxin) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000843">
        <property type="protein sequence ID" value="KAG8176894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYN9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="12" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8176894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="242" mass="27412" checksum="581AE907920DF36B" modified="2024-11-27" version="1">MIEKNELVMYKELFKNITPQITEAHYTTTIKIYQLNFVVITFYLLCLAVVITVTCILKGRKVRILKPPDPIVCYLCKTSYKDEHFQLCKSLIEKEDYDVNYTGADMKLSPFLCACLSGNIELISFMLKRGVNVNILSCDNDSPFYLACTSITPKQSDFKVLDMLLAAGSDINERNNNGFTALHLASARGQKFLVEYLIENGADPDIPTFNAVLPHHLALTSGHIDIAEYLQKVNETRKIEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZ48</accession>
    <name>A0AAV6TZ48_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein FMC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_020994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000839">
        <property type="protein sequence ID" value="KAG8176938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZ48"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20271">
        <property type="entry name" value="Complex1_LYR_FMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037667">
        <property type="entry name" value="FMC1_homologue"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31716">
        <property type="entry name" value="PROTEIN FMC1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31716:SF1">
        <property type="entry name" value="PROTEIN FMC1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8176938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="112" mass="13073" checksum="431246C9D4457469" modified="2024-11-27" version="1">MNIARSHTLSVLRGITHELRRANPKMSPISKTYAYQYIIDEVRNHQVTEKRACKSSEELNIMAKTYLCYLQSLRQNQELLNRYHNKGERSVEETARLVGLQVPNKNPEDKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0D5</accession>
    <name>A0AAV6U0D5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000833">
        <property type="protein sequence ID" value="KAG8176975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0D5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="106" mass="11621" checksum="8CD5B3DB2ADE9526" modified="2024-11-27" version="1">MNKTNRQLNHTLPTKTNPAFRKYQNPSNNSFHTIKENQRIDIKGDPGWPPLRSTAASRVGQSVGRMRGRNCVTAGNGLPRSRPRLRSQLAGAGDVRGSWIGGVNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1A0</accession>
    <name>A0AAV6U1A0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphatidylserine decarboxylase proenzyme, mitochondrial</fullName>
            <ecNumber evidence="13">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="13">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="13">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_011739</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="13">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase alpha chain</molecule>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="13">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase beta chain</molecule>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Single-pass membrane protein</topology>
            <orientation evidence="13">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="13">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="13"/>
    <dbReference type="EMBL" id="JAFNEN010000772">
        <property type="protein sequence ID" value="KAG8177573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1A0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5043063002" description="Phosphatidylserine decarboxylase beta chain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043720021" description="Phosphatidylserine decarboxylase proenzyme, mitochondrial" evidence="14">
        <location>
            <begin position="20"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043063001" description="Phosphatidylserine decarboxylase alpha chain" evidence="13">
        <location>
            <begin position="412"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="13">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="13">
        <location>
            <begin position="120"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="13">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="13">
        <location>
            <begin position="411"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="13">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8177573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="450" mass="50996" checksum="3DA03D5A5A03FFDA" modified="2024-11-27" version="1">MKSWMLAVIVACNVQLVHKSKSSQINYHKSMFTVFSTPSFAGRMPLSTNCILSPYSEVTKRLLADSSVNCQVQNHVHKSSYTEQTWHKTKINPVLRYFRTLKWTPIPLGLGFAYIAYQQFRHVKKRENAKLTSSSNPSDLLASNVYVSMYTMLPLRAVSRFWGWMNTFEVPQPIRTPLLNLFISMYGCNIKEAIVDDVKQYRSLGEFFSRQLKKETRPVHPGKCLVSPSDGQILHFGKIENGLIEQVKGITYSLKSFLGLDSLSNSSEELSVTDEKYEKSVLKNKDNDLYHCVIYLAPGDYHKFHSPAEWSVNSRKHFHGELLSVRPGIVNWISGLFAINERVVYTGEWHHGYFSLTAVGATNVGSIKVYFDETLQTNRKKCMKGTYEDRQFSPAVSITGKGQPFGEFNLGSTIVLVFEAPKDIHFNVAAGQKIKYGELISFCNSTSSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2W9</accession>
    <name>A0AAV6U2W9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000734">
        <property type="protein sequence ID" value="KAG8177939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2W9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8177939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="113" mass="12559" checksum="2C67FD51C51518AF" modified="2024-11-27" version="1">MLAKYNGINFDFFVLLKLAEKSDVSFKIKQNLASAGIRTWAARELGEHSTTEPPMPAKNNEINFEFFVLLRLAAKAEVSIIIKQSLASAGNQTRAASVAILPLKHRCLVRKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3N4</accession>
    <name>A0AAV6U3N4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_015917</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="JAFNEN010000686">
        <property type="protein sequence ID" value="KAG8178547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3N4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000877">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001022">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="48"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="260"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8178547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="585" mass="66646" checksum="E95A5100F922B0ED" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3Z2</accession>
    <name>A0AAV6U3Z2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000688">
        <property type="protein sequence ID" value="KAG8178533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3Z2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="130" mass="14127" checksum="FBC3DE3253D82A7B" modified="2024-11-27" version="1">MGRSCSCRSPSPGVFVLRATTVANSSRLKKTKAMQVESQMFKDTTHDTLDIPAWYCFLMTVSSLITPSVTSCSVLDSISRSCSCRSSLPGAFVLRATTVANSSRLKKTNAMQVESHMFKATTYDTLGIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3Z4</accession>
    <name>A0AAV6U3Z4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_015682</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000706">
        <property type="protein sequence ID" value="KAG8178271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3Z4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000078">
        <property type="entry name" value="glutamate receptor ionotropic, NMDA 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8178271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="410" mass="46169" checksum="EB74667689E9617A" modified="2024-11-27" version="1">MKFPKFLRVAVVPRAGIFQVNRTNSGKLQVVGGDESEFLELLSKALKFDYEVIIPDRGTWGDMVNGTWTGVVGMVHRGYADIAIGKTSITYERTTVVDYSHPYDIEHLTFATNIPGHLPKTDSFLMPFDATIWSAVLVMFIVFAIAFKIILPKQPFQLTILKLLRYILYQPLDIVATKASSSVLLFTWLVLVRLIPMYYSTALLSFLTIPERGQGIEDVTDLGKRITLGTYKAVTFAGSAYVFTMKSSGNDYIRATGEAIEQNDWFVLPDKKSVSNVLKNDDTAVIAPRRFLKRNLNNVHISRDSFVLLTRAIVLKKNFCCSDILNKYLLRLCAGGIYWKILNDAMFLEKLSSRAAETFQDDPPVKNLTTEDVSGAFILILAGYVLSALVCILEVVIFKIKRRKKKFAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4L9</accession>
    <name>A0AAV6U4L9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000643">
        <property type="protein sequence ID" value="KAG8179235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4L9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="61711" checksum="68B3042F0A2A76CA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6M7</accession>
    <name>A0AAV6U6M7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000577">
        <property type="protein sequence ID" value="KAG8180207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6M7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="352" mass="40776" checksum="FAB50E028FC5B46E" modified="2024-11-27" version="1">MSQFCFICSKPLNESKIVVVDRGIKTLIDSSVERNDGLFEHLKDQKSITIHMECRKIYTRKSTIVAVKRQNEIEEASTSKSSPPRTRARVNESHFCLKKDCLFCGFEASEESEKKKALNDRRKISKVATLEFKESLLKVARARFDDVAKTVTARIEYEHDLVAAGAKYHTNCFHSFLRPNTGSKIGRRQDESINLAMAEIFTYIENSDDCQFSLEELKDVCKNPAIDNRTIKLRLKLKYGNKIIITEKPGRLTFILFIDNKLDILSTVWYENKKENEGEERFRILKAAAAIIREDIQSAVFDNNDNYYDINEEITDASLCEQFIDIQQEEEDEEEREEDIIVEKGFEDYQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7A2</accession>
    <name>A0AAV6U7A2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000623">
        <property type="protein sequence ID" value="KAG8179486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7A2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28020" checksum="223BC93B1A5CE607" modified="2024-11-27" version="1">MEGNEMNVFAQTHNCNGEKEDSTNDNISRHSKGGFRHFVEESTLRNVCLDELEELSDSGCTSSMDRVARRTPSIASSEPPVRFAIILEWHRRYFYSGEGMLRLAFLISTTASLACVSNAGSNDTDILDMSFESCIRAHIFVTVLAILVALAFFILGVTALIKTFPLYWNSIDALVHGCLCVVLLFSSAMLLHAEHLVYFGDPPMTEWAKLHLSLAAAFGILSTIIGVFITATRSCASKAPDISDEIVLQSLRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8G9</accession>
    <name>A0AAV6U8G9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Venom dipeptidyl peptidase 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_028724</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9B family. DPPIV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000583">
        <property type="protein sequence ID" value="KAG8180138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8G9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="17">
        <location>
            <begin position="134"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="16">
        <location>
            <begin position="598"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8180138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="820" mass="94431" checksum="B40B840AA52162FB" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8X2</accession>
    <name>A0AAV6U8X2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000559">
        <property type="protein sequence ID" value="KAG8180529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8X2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="222" mass="23622" checksum="DC20B528A168CF15" modified="2024-11-27" version="1" fragment="single">PHPVMKTLPGTPPPVASRTRGKTVPHDPPVTPPGAPQPPPVTMEPPSDSVPVPVTHTASSPGPKNSPSSPLLDENWSLVFSWSLSQRANYSRSETPRLPSRSIPSSETEQAQKITLPLPTLVPGSPPYPATPPALLPVCPRSPSPTPATAPGVNTSWSLAFNPPPLLRGHAGTPAERDPPQRRKGVHNTAEDPHSTTPPSPLPRMRAPEWLPTRPHLIGDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8X7</accession>
    <name>A0AAV6U8X7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cat eye syndrome critical region protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000571">
        <property type="protein sequence ID" value="KAG8180258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8X7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090537">
        <property type="term" value="C:CERF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029614">
        <property type="entry name" value="CECR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47092">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47092:SF1">
        <property type="entry name" value="CHROMATIN REMODELING REGULATOR CECR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="61750" checksum="432F8F54994A9BCE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U965</accession>
    <name>A0AAV6U965_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear receptor subfamily 2 group B member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_020960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family. NR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000591">
        <property type="protein sequence ID" value="KAG8180005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U965"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06956">
        <property type="entry name" value="NR_DBD_RXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06943">
        <property type="entry name" value="NR_LBD_RXR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000005">
        <property type="entry name" value="Retinoic acid receptor RXR-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000052">
        <property type="entry name" value="Ultraspiracle nuclear receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000003">
        <property type="entry name" value="Retinoid-X_rcpt/HNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00545">
        <property type="entry name" value="RETINOIDXR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="85"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="180"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8180005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="399" mass="45058" checksum="3281235161F50C33" modified="2024-11-27" version="1">MTDVERMADFSDDDSSEFFPESTAVNNTLSNSSLSNGGTLSSSTVSSSFATSAFSSIHGNYTQISSPQNPSSPQYPANHPLCGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACREERNCIIDKRQRNRCQYCRYQKCLSMGMKREAVQEERQRNRERSENEVESTSNIQPDISIERILEAELWMEAKKETDASNICQVSDQQLVQLIDWAKHIPHFNNLPLEDRTILLKAGWNELLIATFCHKSVGIKDGIVLPSGHIVHRNSAHSEGVGMIFDRLLSELVAKMREMKMDKTELGCLKAIILFNPDAKNLKSTTEVGNLRDKVYTALEDYCKQCYPSETGRFPKLLLRLPALRSIGLKCLEHLFFFKLIGNMPIDHFLISMLEQPSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9W8</accession>
    <name>A0AAV6U9W8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="22">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">JTE90_012965</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 22">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="22"/>
    <dbReference type="EMBL" id="JAFNEN010000549">
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    </dbReference>
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        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
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    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 22" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 22 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="950"/>
            <end position="970"/>
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        <location>
            <begin position="494"/>
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        <location>
            <begin position="844"/>
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        <location>
            <begin position="1010"/>
            <end position="1282"/>
        </location>
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        <location>
            <position position="1043"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAG8180786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1407" mass="159812" checksum="3E70A9D421A9869F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAT2</accession>
    <name>A0AAV6UAT2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000524">
        <property type="protein sequence ID" value="KAG8181264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAT2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="19699" checksum="A8B53D7E5BADE031" modified="2024-11-27" version="1">MKRTNSVISSMYHPIGNSKIKTALCMFAGGLILVCLGVCLIVTTLSVSRPSAINDNETSVLISGPTCLALGTVIVVFSGNDMCRYRRAKNNVESELNSVISSLSKQSPRNSHADVVTLPTPKVSICLSIGTVIVVFSGNDMRHYRRAKNNVESELNSVIISLSKPSPRNSHADVSHCPLQKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UB25</accession>
    <name>A0AAV6UB25_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chaoptin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_010646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000542">
        <property type="protein sequence ID" value="KAG8180898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UB25"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043338905" description="Chaoptin" evidence="4">
        <location>
            <begin position="29"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8180898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1011" mass="112668" checksum="5D426D0AA1CCCD22" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBL5</accession>
    <name>A0AAV6UBL5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_017314</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the JMJD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000507">
        <property type="protein sequence ID" value="KAG8181564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBL5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033749">
        <property type="term" value="F:histone H4R3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106140">
        <property type="term" value="F:P-TEFb complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.270:FF:000001">
        <property type="entry name" value="Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000010">
        <property type="entry name" value="bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF32">
        <property type="entry name" value="BIFUNCTIONAL ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="13">
        <location>
            <begin position="150"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="344"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8181564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="403" mass="47162" checksum="FE1CF2CA6BA3673F" modified="2024-11-27" version="1">MENDFDKFLRRAYKRIDEAKARARPELIDKDGNGWTKLNYAGTFELDLNAVKDNVERIDVNEVPPDVFIEKYEKIYKPVVISGCTEQWKARYKWTLQRLARKYRNQKFKCGEDNEGYSVKLKMKYFVHYMQHNKDDSPLYIFDSSFGEHPRRKKLLDDYSVPIYFQDDLFKYAGEEKRPPYRWFVMGSGRSGTGIHIDPLGTSAWNALVEGHKRWCLFPTHTPKELIKVRPEEGGKQGEEAITWFRYIYPRTQLPDWPSECKPLEILQKPGETVFVPGGWWHVVVNMDTTIAVTQNFCSLTNFPIVWHKTVRGRPKLSRKWYRVLQEKRPELIAIADRVDVKSKTGMASDSSSGSSSSSSSYESSCCSSSESDDSGKESISDRKRKRRWSSRDIDRDQKHYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBV5</accession>
    <name>A0AAV6UBV5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Growth arrest-specific protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000493">
        <property type="protein sequence ID" value="KAG8181852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBV5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039596">
        <property type="entry name" value="GAS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16840">
        <property type="entry name" value="GROWTH ARREST-SPECIFIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16840:SF3">
        <property type="entry name" value="GROWTH ARREST-SPECIFIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41795" checksum="0D1C657E81D264EE" modified="2024-11-27" version="1">MKERPYSCTAAVVSICLQPNDPQTPQLTFDEAYLSFSTEKIRDSKEDMFYDSLLATTTEQSRLQKLVLSLRASRHAQSLFHSTIKTTDHVDSSDMMLILLLIAAVHCGANTLPGPQDCELARAKCAYRAGCYKALHAYMVGCADVLTGRTARCPFSCQRALISLTSTEYGLALSTCDCGDNEFCRKSKERIEVCRPEVSHATADNTVVSCSVAKWICAADTLCSTALDFYHRLCRPMFHGRKCTPRCNNSLAILDRQEKAGKLRDCYCDGSEDFPCYDMKRNTDRLCYGRVDILDRHFPKTATARPGQTAGSGPSSGRPANVVVYLLKFVVVGWCQGISRSGLGGGDLREFREWCGEKLQKVINNFMKPVKKMMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBX7</accession>
    <name>A0AAV6UBX7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SS18 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_019222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000501">
        <property type="protein sequence ID" value="KAG8181684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBX7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007726">
        <property type="entry name" value="SS18_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05030">
        <property type="entry name" value="SSXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SS18 N-terminal" evidence="3">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="349"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="469"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8181684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="541" mass="56183" checksum="A30BA5818B194617" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCS1</accession>
    <name>A0AAV6UCS1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adult-specific rigid cuticular protein 15.7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_014363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the rigid cuticle of the spider.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000485">
        <property type="protein sequence ID" value="KAG8181984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCS1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044000638" description="Adult-specific rigid cuticular protein 15.7" evidence="4">
        <location>
            <begin position="18"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8181984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="19369" checksum="938CC8AB8F60F09A" modified="2024-11-27" version="1">MIAKISILFAVLAAVNASAILYGHGHLVNTGVSARSQGQDGHGNYAFGYDIKDGKGATNSRSEVGDGHGNVKGSYSLADIDGRARKVEYVADGHGFRAVVKTNEPGTAASAPAAALIASPYAAPSDNVVSHIAAAPALHGYASHGAPLVAAAPIAYGGLVGHGVGLGHGAVLGNGYGLGYGAALGHGLGLGYGLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCS4</accession>
    <name>A0AAV6UCS4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc finger RNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_004002</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000493">
        <property type="protein sequence ID" value="KAG8181855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCS4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.40:FF:000001">
        <property type="entry name" value="interleukin enhancer-binding factor 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000153">
        <property type="entry name" value="Zinc finger RNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000210">
        <property type="entry name" value="Zinc finger RNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000010">
        <property type="entry name" value="Zinc finger RNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049402">
        <property type="entry name" value="DZF_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049401">
        <property type="entry name" value="DZF_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762">
        <property type="entry name" value="ZINC FINGER RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762:SF3">
        <property type="entry name" value="ZINC-FINGER PROTEIN AT 72D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20965">
        <property type="entry name" value="DZF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07528">
        <property type="entry name" value="DZF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00572">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DZF" evidence="11">
        <location>
            <begin position="518"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="284"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="849"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="869"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8181855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="900" mass="99989" checksum="CCE7C52DB182E7D5" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGE5</accession>
    <name>A0AAV6UGE5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">P-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_006453</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000425">
        <property type="protein sequence ID" value="KAG8183257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGE5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017957">
        <property type="entry name" value="P_trefoil_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF131">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 31 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00018">
        <property type="entry name" value="PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57492">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00025">
        <property type="entry name" value="P_TREFOIL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="11">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8183257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="916" mass="103501" checksum="E04F98D25B4008D0" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHD3</accession>
    <name>A0AAV6UHD3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_005622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000412">
        <property type="protein sequence ID" value="KAG8183634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHD3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF0">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="919"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="175"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="398"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="664"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="833"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8183634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="938" mass="109308" checksum="0EEF87D919FE242B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJ58</accession>
    <name>A0AAV6UJ58_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_010222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000385">
        <property type="protein sequence ID" value="KAG8184187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJ58"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159:SF1">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="81"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8184187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="347" mass="38825" checksum="363F19B865ACD29C" modified="2024-11-27" version="1">MLLDGEKRLGELQIGDSVPTPGLNKTTSDEPKFPEWFDAKKFQRAKDVYRDHFASVNFGHLCGLLLSFYFTKNIVTLRSTGNSENRNVLFRRYLSTVQHVRGWYEGDVWDKQDAARKSLDTVRTMHARVAQRMRQRQEKARKEGADHVESNSKTEAVVDAHVDVDAVYVSQWDMAVTQWAFAGTLVLFKDKVGLGCCSAADLEALVHFWRGIGWLLGIEDAYNLCGGEMAHVEAACRAMLETEYAPRAAAPHPASTRMVVGVVDALKLLDPTLSPAAMQAYCRDLVGVSPGEELSWADWACHALTSFFMRHAMRYETPRRMLNGLTRWRLDHADTALEAPSTGVTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJK7</accession>
    <name>A0AAV6UJK7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cathepsin O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_005185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000395">
        <property type="protein sequence ID" value="KAG8183954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJK7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044000644" description="Cathepsin O" evidence="7">
        <location>
            <begin position="25"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="131"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8183954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38844" checksum="4BFD4CF0B66BA186" modified="2024-11-27" version="1">MSLLAAFHLAVGSGLLLYVFPSNGVQNNDLLPRFTDYIRRFNKSYEVGTMEFKKRETIFEQTLQRVAWLNKHRNSTYAALYGINQFSDLTPDEFKEKVHLTKSNTTAKKTSPSSYPLLRFPLLGNTKIKDLPKKVDWREKKIITPVNDQEQCGACWAFSSVETIEAMHALKKGSLEQFSVQQVIDCAAPPNKGCGGGDTCLSIEWLYESHTKVVLAKDYPFTGKTGSCKKEVKSEKSIQIAKNFTCDSFVGEEYLMLLHIAHHGPLIAAVDATGWQDYLGGIIQFNCDSERNHAVQIVGYDITGEIPYYIVRNSWGTKFGNDGYLNIIIGKNMCRIAEEVSAVDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKN7</accession>
    <name>A0AAV6UKN7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) kinase</fullName>
            <ecNumber evidence="2">2.7.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_012097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000358">
        <property type="protein sequence ID" value="KAG8184849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKN7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000003">
        <property type="entry name" value="NAD kinase b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8184849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="559" mass="62371" checksum="34E1901375963A1B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKN9</accession>
    <name>A0AAV6UKN9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000362">
        <property type="protein sequence ID" value="KAG8184782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKN9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="68" mass="7696" checksum="BF90983A77069EA8" modified="2024-11-27" version="1">MLFSTFVSPTKSYLQLFHSNTAQIVYESIRDNLESPVPLGRERLQLLVTILSDHQELQTSTKGEKGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UL29</accession>
    <name>A0AAV6UL29_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000393">
        <property type="protein sequence ID" value="KAG8183991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UL29"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053236">
        <property type="entry name" value="Cornifin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13884">
        <property type="entry name" value="DUF853 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13884:SF9">
        <property type="entry name" value="PROTEIN CBG13449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="305" mass="35554" checksum="679A6CD2378E6CA6" modified="2024-11-27" version="1">MSVDSRVFRNSRNCRDPEFAKLPRYGIRETAEIRNSQNCRDTEFAKLPRYGIRKIAEIRNSQNCRHPEFAKLPTPGIRETADTRNSRNCRHPEFAKLPTPGIRETAEIRNSRNCRDTEFAKLPRYGIRETAEIRNSRNCRDTEFAKLPTPGIRETADTRNSRNCRDTEFAKLPTPGIRETADTRNSRNCRHPEFAKLPTPGIRETAEIRNSRNCRHPEFAKLPRYGIRKTADTWNSRNCRDRNSRNCRHPEFAKLPTPGIRETAEIRNSRNCRDTEFAKLPTPGIRETADTRNSRNCRHPEMFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULC1</accession>
    <name>A0AAV6ULC1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000341">
        <property type="protein sequence ID" value="KAG8185265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULC1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="95" mass="10878" checksum="142653DEF1560B6C" modified="2024-11-27" version="1">MSHPKPAYQIPHPHPDSTTCPHLAKRHGTFPRFECLTSNYRSTYPIPGLSICSRCLMFCPLRSRHLYSCDMRLHPFQSRLLQALLFAFAVSMSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULH3</accession>
    <name>A0AAV6ULH3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000348">
        <property type="protein sequence ID" value="KAG8185082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULH3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="82" mass="9158" checksum="4A62F66E8460367C" modified="2024-11-27" version="1">MILPVPLRCLHKSLFYSPALSILGPETFALALYPALPFRHHAFTLKQSESSLFLMSGHKPSITWPRASSHLPTAGWRDRMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMT8</accession>
    <name>A0AAV6UMT8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000354">
        <property type="protein sequence ID" value="KAG8184928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMT8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="503" mass="54998" checksum="7ED7792B177ADEDF" modified="2024-11-27" version="1">MLGFKVFIVTRLFSSLITKEKMDRSLNENSDQSSIDDIEESALHESLTDDKDSANDSACSTEETLKNESEPGKDYQAFDSNDEASSADLSKGELDLIDKKVREVCKDTENYQRLTMEAKRMKYSEDNKPSSAESSTVANAGLVSFPNENIIDVPTKQASESSISTSTAISRAQTKSSEPLAIPSTSKGPSGLAPSSKSSPKRPTNFGRNVKQAIHVFHPINPKSILQKVPIPIHSGRWVYLRDSPESSDYGGSPDSLDDPFLMEALCVKTPECENEDMFTPRNEEMPPCPPPIQNPVLDFDTPVGELAISEGGLLSDPGHYKRTFGDVPSSHTKQNIEDYSHEPGSIPGIAEDKPLRGEGLPCTNDYPERAVESLLSDLASMNSADSFKQLNSESSCSSRSKGDASNKSSSNIQDIGDKELESVTMQKTSENLDPRLNDSQINVEDYPSESALTEENMSSELASELSNIESNTVIEDRLTESSLALKIHFAELSSEEMLKDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNI3</accession>
    <name>A0AAV6UNI3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000341">
        <property type="protein sequence ID" value="KAG8185263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNI3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8345" checksum="D1F3BF7876AA973D" modified="2024-11-27" version="1">MPVLSPAWSTSVPVRYASTPISIPCTTNVAVHVHIPNVWRLSRDVDVRVSTFTRSGRHLQCPRGHPWIKSERSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ98</accession>
    <name>A0AAV6UQ98_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_005861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000305">
        <property type="protein sequence ID" value="KAG8186329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ98"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12934">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03020">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="LEM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8186329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="280" mass="32172" checksum="267A039ADFC0E6CB" modified="2024-11-27" version="1">MENSSDEDLRKLLKAYGQDVGPINNSTRPYWKKALSKLTIQHVSPITSTSKKGTREKKLISENKKFVASPTKSLIYISKCTDRSFSEEDLSDSENDSVVMDSPGSTPFPAKTQRIKKSPLIKNTKTSPVETLAIYANRKNCHHSTTPSSTRNPKVKCFDGKSIEIQQKDRELRKKFKEYGKSLLRSPMNDAMIEQWRKRQNKLQCHLPEKNIYDFEDCQDEFETEYEFDAPRPSDKHIKKNMITLFTLLLKGIVCAIIIIIGIFLMLSSEDIKRIEESLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQF0</accession>
    <name>A0AAV6UQF0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000322">
        <property type="protein sequence ID" value="KAG8185861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQF0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="9124" checksum="8F9A7986A361634A" modified="2024-11-27" version="1">MELDDMKPDEMELDDMEPEEMELKDNDPEKIELKDTEPEEMKLQDNEPEETKLLVMEHERMNFEEIDSEDMEMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UR51</accession>
    <name>A0AAV6UR51_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_009799</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000292">
        <property type="protein sequence ID" value="KAG8186730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UR51"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8186730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="207" mass="23887" checksum="8093068894B838F6" modified="2024-11-27" version="1">MIHTGERPHGCSGCDRRFSNKAHLDKHALIHIKEKPYKCDRCHKAFPVDAALKRHMLTHTQEKPHPCNLCPKSFTKPSHLASHMAVHSKEKPYCCEVCDKRFRLSEDLEKHRSMHEGGAKIYSCGACDKEFTRMSTLKEHMLIHTGEKPHVCEACNKSFRRASNLKAHFLVHSGEKPHKCKICQEAFTWKEQLRTHHLSSHSEAKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UT54</accession>
    <name>A0AAV6UT54_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000283">
        <property type="protein sequence ID" value="KAG8186954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UT54"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="95" mass="10788" checksum="DFA24DEBA8C2C4B8" modified="2024-11-27" version="1">MRRTKLSVERIVAFCSQTKKEERNKENPPNSRHIRFYKNIHCFVEGSGGDCEGVTEGGVRNNCVTRSRTLTVWEALATTRECCPLPESSSWLQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUK6</accession>
    <name>A0AAV6UUK6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_020061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000277">
        <property type="protein sequence ID" value="KAG8187190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUK6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19343">
        <property type="entry name" value="Wnt_Wnt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF102">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043888132" description="Protein Wnt" evidence="10">
        <location>
            <begin position="20"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8187190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="356" mass="39225" checksum="D34620CDED160CCC" modified="2024-11-27" version="1">MVSCFLWIGVVLGIGSTGASPLPAAPLHWLGFHMNKMSVSWENPSMCVRAFKQNLLASVQKAACKRNLALMPTVVSTARKVSDVCQEAFSRHRWNCSSITLAPRFGQDLVRGTSEQAFVSSLASAGLAINIGRGCAEGRIKTCGCGRPSKEPPPSDFKWGGCFDNIGYGVTASKAFSSEPFDRRKFRADEAVRLHRHNSRVGWRAVRSSWRLQCKCHGVSGSCEVKTCWRSLPSLSEVAQKLKLKHRDAEEAHPVPVGRRKKLLPSAALFNKDDLVYTVKSPDYCVYDPNSGSAGTKGRQCNSTSTDSFSCEAMCCSRGHLTTWIETEERCGCKFKRCCYVTCDTCKLRTNVDICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUU2</accession>
    <name>A0AAV6UUU2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C19orf12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000275">
        <property type="protein sequence ID" value="KAG8187286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUU2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033369">
        <property type="entry name" value="C19orf12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31493">
        <property type="entry name" value="NAZO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31493:SF1">
        <property type="entry name" value="PROTEIN C19ORF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20721">
        <property type="entry name" value="C19orf12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="156" mass="16538" checksum="A9BCA6DD275ACEBB" modified="2024-11-27" version="1">MIRLLRSFSLGPMVNGIMPISTSDVIDLLCTVAEEERLKVTFSESLKGGLITGLGAAMGAVLLGPIGFPIGGALGGGVAALTCGTKFQPVSQVIATMPQERRENLANKIKNLMNRFEVADVILFAALVSGDCSIRSKVVGELVDYLRHEMSMALVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUV1</accession>
    <name>A0AAV6UUV1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000268">
        <property type="protein sequence ID" value="KAG8187543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUV1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="10827" checksum="EFC34F4402C90430" modified="2024-11-27" version="1">MSGLYSSISYTLLRPFSGIKKGNPSVVYPSLSPFPRQRTDAIRQTRIFLRLKLCPYYLLLVMSTSDVLPRGGITGSMLDQQVSAASQKRRSLDTGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUW4</accession>
    <name>A0AAV6UUW4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Paralemmin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000264">
        <property type="protein sequence ID" value="KAG8187638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUW4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="20795" checksum="A5599A2C15660146" modified="2024-11-27" version="1">MAIPEEENVCNGTAHVVTEESRVHPAKVRVKFIESQSVAQVTPPSPDVTLDFESMTSPASEHSPDYHRKVSHESGIDNPFRPDGELSREAEAIVSLIQAGKPITPVKGDELLEMEGVVLNGFSHDTTDNGDVMVKKEVATTESSAPPKGGANGNAPKSPGVVEVQRGVIVPPTDAPAVEQVVIKKKPKCKCCVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UV64</accession>
    <name>A0AAV6UV64_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prokineticin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_009888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000251">
        <property type="protein sequence ID" value="KAG8188014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UV64"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023569">
        <property type="entry name" value="Prokineticin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06607">
        <property type="entry name" value="Prokineticin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043473535" description="Prokineticin domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Prokineticin" evidence="5">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8188014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="103" mass="11508" checksum="3D392998D068D692" modified="2024-11-27" version="1">MKSLAGILLVSLFCVVFVKSEKQFAQKLCRTAEDCDWDQCCIDAITRLPGFKGICSPPTQKGEICNPNTNDMIEGRYRKACPCDSGLTCKHSEKEESLFVCQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWK7</accession>
    <name>A0AAV6UWK7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000231">
        <property type="protein sequence ID" value="KAG8188757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWK7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="149" mass="17021" checksum="9D9F18B421F031A5" modified="2024-11-27" version="1">MTETSQWQHVASEDNPADLVSRGLEPSRLVNNELWWHGPSFIQSEIGGTPVRLNLHSSDVEYLEQETKTVMLAKEDSDFLGDILGISNCFDKIVRVLGFIFRFVSNCRGKKQQRVLHIGPLSTQELSNAKRHVVRLVQELKFKEDLVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXP9</accession>
    <name>A0AAV6UXP9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_008048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXP9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043944442" evidence="3">
        <location>
            <begin position="21"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8188483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="185" mass="19771" checksum="B775D655F754582A" modified="2024-11-27" version="1">MRSFMVLLFTVVLLVEYSSALGYGTEGGDIVPGYDYGMVSNSRYGGSQVGKLGNSKPTPFNMEYEAADEQGNAHYRREVGDGNGKVQGSYGYMDNQGLYRSVEYMAGPEGFTAYVKTNEPGTNGKENPADVVINVQETPAGIVEKYNRRSQNGPGFSYMGNGGSGMSMDGYSQSGQGAKSGKSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZ45</accession>
    <name>A0AAV6UZ45_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_008464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000213">
        <property type="protein sequence ID" value="KAG8189502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZ45"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19723">
        <property type="entry name" value="bHLH_TS_ASCL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000029">
        <property type="entry name" value="Achaete-scute family bHLH transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="73"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8189502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="212" mass="23224" checksum="149984F10F3CE504" modified="2024-11-27" version="1">MTTLTLIGGPMDSTYLLTTSTSSTFTSTGSTTTTTPSPKIAPKRQRQESTSSSSETPQQRPPKRTRTTNGAPPAVARRNERERNRVRQVNQGFQTLRQHVPNGAKSKKMSKVETLRSAVQYIKQLQQLLCGEDMEDEEENSVPSFDEQFRHLRPQNFPSEYSGTSSAVNGFGGGLTPASSPSPSLGSDASSPYDSTLSPEDEELLDFTTWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V0G9</accession>
    <name>A0AAV6V0G9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_023051</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000195">
        <property type="protein sequence ID" value="KAG8190079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20104">
        <property type="entry name" value="MBT_PHF20L1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043449">
        <property type="entry name" value="PHF20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15856:SF51">
        <property type="entry name" value="MBD-R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15856">
        <property type="entry name" value="PHD FINGER PROTEIN 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="337"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="515"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="647"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="783"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8190079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1292" mass="145085" checksum="B131F693F038A463" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V120</accession>
    <name>A0AAV6V120_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000219">
        <property type="protein sequence ID" value="KAG8189256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V120"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8189256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="363" mass="41496" checksum="75CB3ED62806FD38" modified="2024-11-27" version="1">MKEIPKDVIEEMLSNKEIPFQNRIIDWKSFYKKWYRGKFMKRNKVSIESVQAFCANPVTCMKASGCFILTGHSNGEYYGSETLPFSHHHVISISKDSCIKIKCLLEPIVCVERDKVLNKHGDVLSSVKVFGNCFAVSCRDNTVTLWGLQIAKHMEHYLQVTLLKTIIGPQDNLLSSGFWNNKVYCVTHAGKLRVYEASINEWPEETSFKKCLASVREKRPNITAYYLFRDKIILMCSASGKLIVSIDDDNYKAYNLMETLRTLIVSVILQGTTLALGGENGRLYVFYVPTSRSLLDLDFSHPTFVFTLSEASIVSLDILYDYDSPVILASTTETLYIVKWFGKKVKIERTEATSYFENRILIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1U0</accession>
    <name>A0AAV6V1U0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000181">
        <property type="protein sequence ID" value="KAG8190529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1U0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8764" checksum="A1C511FE8D559059" modified="2024-11-27" version="1">MIISRAEIPSSLPSSITIDSSQREREEHGESIYRFPTFTRMKYLTRDDQTLAREQIFSIVIALLAERQGWHLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V390</accession>
    <name>A0AAV6V390_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_016673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000165">
        <property type="protein sequence ID" value="KAG8191160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V390"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="527"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="802"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8191160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1149" mass="128759" checksum="F79EDB8204C97F6E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3I6</accession>
    <name>A0AAV6V3I6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 9">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_003262</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 9"/>
    <dbReference type="EMBL" id="JAFNEN010000162">
        <property type="protein sequence ID" value="KAG8191250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3I6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.200.10:FF:000003">
        <property type="entry name" value="Carbonic anhydrase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043099100" description="Carbonic anhydrase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="10">
        <location>
            <begin position="61"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8191250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="345" mass="38965" checksum="8099A738B37FDC60" modified="2024-11-27" version="1">MLRTLLVGSLILLLPLGALGVSLHDLVKRDAKDHKSPWNYEDKTGVSLHDLVKRDAKDHKSPWNYEDKTGPRHWAEMYKKCGGSRQSPIDIVKEEVDLNDELDAFEFDNYEDNLSGATIENNGHTVEIKPGPKDEARLIDEGGMDDTYQFIQLHFHWGADSKRGSEHLIDGKKFPLEMHFVHMNTNYKTKEKASMKEDGLAVLGVLFKIDDEDNPALTPIIDKLDDIRNEGDKVNMDDFTLESLLPDDLMPYYRYKGSLTTPPCSEIVTWTVFTDYVPISEKQLQQFRNVKENDEGEAPESLVDNFRPVQPLNGRIIEISGDGNSARVIGPSVALVGLAALAFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V423</accession>
    <name>A0AAV6V423_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_020724</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000159">
        <property type="protein sequence ID" value="KAG8191475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V423"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23821">
        <property type="entry name" value="RWD_IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="7">
        <location>
            <begin position="13"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8191475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="296" mass="33528" checksum="CD8E2A720233F880" modified="2024-11-27" version="1">MESSTENKTLQEEEIEALSSIYGEEWVLEDYNERVYSINITSSSKKCLYFQVILPNSYPLKSPPVYRISCPWMSRQAKNRLSLILDEIYSENIGESIIYQWIIHVQDFINEQDVNGASSTFEDCSAELAENLLAVDLLDKVDKLAYSDASNGGWSDEIPLIQHGETIMDRKSVFQAHVAKVVSVKQVKQVLQNLKENKKIAIATHNIYAYRISRENQSFIQDCEDDGETKAGSVLLHLLQVLDVSNVLVMVSRWYGGIHLGADRFKHINNAARSVLLDSGFITKKETPKKSKKTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V4M1</accession>
    <name>A0AAV6V4M1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000172">
        <property type="protein sequence ID" value="KAG8190865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V4M1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="123" mass="13660" checksum="61441D7790D43756" modified="2024-11-27" version="1">MVRKVSETVTGRRPTVETVISEMWLSPEPGQKDGPAHVRADAQLLQKKLSSSKASMHTHLRRVTGISQRSSAGQKDDCHLLRVIKTTPDERWIKAEKGPQCGENLGNEFFSTSSSTAKCQQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V665</accession>
    <name>A0AAV6V665_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_025328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000146">
        <property type="protein sequence ID" value="KAG8192064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V665"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000058">
        <property type="entry name" value="CUB domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF2">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="42"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="179"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8192064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="340" mass="38744" checksum="CF6F095B68B5F720" modified="2024-11-27" version="1">MFSCYLQWILITSNSPIKVVSVCDSQHLVLSHIRAHGFPYHCGQEFSSEVSRNGTFTSPQYPEPYPKDVFCSYTFQGRGKERVQIQFTDFDLHLPHEPPRDCESVDAVMVFITIKGQKERVDNFCGNKLPAQLMSNGPSMTVEFRSHHSSPEVKGFRAIYKFVTDFGISSGKQDSASVCGFNFNSEERSNGTFTSPNFPGLYPRDTECHYFFRGRPKEKVHITFNKFDIDGIPPCTSETASDYVEFSNYQSVDRKIPRHCGFKKPKVIESDGDYFRVSFKSNDKFDGMGFEALYHFKPYIDPATVKRISSTTSNSSSSDTLFRPYSILLMLVPHVIDMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V691</accession>
    <name>A0AAV6V691_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_014084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000142">
        <property type="protein sequence ID" value="KAG8192224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V691"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF6">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="869"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="148"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="289"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="430"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="568"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="702"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8192224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="926" mass="105299" checksum="C24288AF494ED615" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6K0</accession>
    <name>A0AAV6V6K0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Calreticulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_006058</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 17">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6K0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000002">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000122">
        <property type="entry name" value="Calreticulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009169">
        <property type="entry name" value="Calreticulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF2">
        <property type="entry name" value="CALRETICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002356">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 14 17" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 14 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043087294" description="Calreticulin" evidence="17">
        <location>
            <begin position="20"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="203"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="344"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="344"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR002356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR002356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR002356-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8191306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="409" mass="47100" checksum="C6FDC24547BEC0BA" modified="2024-11-27" version="1">MKGPFILFVVQLFISLSLAKIFFKEEFTDGDKYKERWTPSQHSGKEWGDFVLTHGKFYGDAEASKGIQTSTDARFYGLSTKFEPFSNKDKPVVFQFTVKHEQNIDCGGGYAKIFDCSLDSKDMHGETPYLMMFGPDICGPGTKKVHVIFNYKGKNHLINKEIRCKDDVYTHVYTLIVKPDNTYVVKIDNEKVESGELEKDWDFLPPKKIKDPEAKKPEDWDDNPKIEDTEDKKPEDWDQPEYIPDPDAVKPEDWDDEMDGEWEPPQINNPAFKGEWKPRMLDNPNYKGPWVHPEIDNPEYVADSSIYKYDEICAIGFDLWQVKSGTIFDNILITDDEAEAEKHARDTWGAIKEAEKKMKEQQEEEERKAAESKTADTEEDNDDDDDEADELDIPGTTEDATDADAHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6Z6</accession>
    <name>A0AAV6V6Z6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000138">
        <property type="protein sequence ID" value="KAG8192525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6Z6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9492" checksum="323D93C3D9DDB7DD" modified="2024-11-27" version="1">MPSHGSRSVSPPQYRPQFQPIPARPAMSQRLVPPQNSSNFRKRQLPQVPSFSRSDLEERFLKGRNPAPGTAPGTVGFECGTLSCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V765</accession>
    <name>A0AAV6V765_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 16">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 16">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_007718</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 22">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 16">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 16"/>
    <dbReference type="EMBL" id="JAFNEN010000149">
        <property type="protein sequence ID" value="KAG8191918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V765"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14294">
        <property type="entry name" value="UBA1_UBP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000016">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000026">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF10">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 16" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 16" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="19">
        <location>
            <begin position="164"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="18">
        <location>
            <begin position="315"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="610"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="674"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="757"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="210"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8191918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="798" mass="89799" checksum="E7FD493FE947C53B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V791</accession>
    <name>A0AAV6V791_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000158">
        <property type="protein sequence ID" value="KAG8191516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V791"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8191516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="323" mass="36208" checksum="C642644A61D2CA28" modified="2024-11-27" version="1">MADEGSNSQEVAFETPWPLSPNSTEAMLDFYEVFDSDIIFVTDSCEKKEIKSLSNQEANCKFSKELLPLSSTSQQIGEDSISKKAKMKRSTDTDLSTVPTKVRHVDPNENKTVQLTLGPIDNGSPSTSHKNMTANTEIKRTLPSEKTSSPWICANAPDLSIMMKNYRESKTNQNKWSVGKWLIYSNRVRMMPQKNITYHDYAWCCIQNLVENNPSSVTGVFSAKASTAWATEYEARANCSGVICCYVIDSSDKHLAKRAADAIRKAYDCGGDMYYKTDGDTSANKYCHLGSKNVSIYKHNVANKMFERDSKCSYGWKLVCLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V7G3</accession>
    <name>A0AAV6V7G3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000139">
        <property type="protein sequence ID" value="KAG8192397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V7G3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8192397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="10935" checksum="F0574F51DF3242C4" modified="2024-11-27" version="1">MIRPFIVSQVNRLSPNDFHRFGREEVFPAKNQRREWSGVVSSFSSGWLLFLGPMMGKRGLLGNAFTAIVGVLGYFCTSNKPGDFLNRLLYGSTIDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V9F8</accession>
    <name>A0AAV6V9F8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000138">
        <property type="protein sequence ID" value="KAG8192575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V9F8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7941" checksum="527E90EE0950ED07" modified="2024-11-27" version="1">MLPFLVNSRVSIEEESSEGAIHSKNVVQMEDITSPLVKQIFDSMAYSGRELHKSIRNEAHKEKDRNNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAE3</accession>
    <name>A0AAV6VAE3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000132">
        <property type="protein sequence ID" value="KAG8193058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAE3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="75"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="242" mass="28929" checksum="60C50F7E50615671" modified="2024-11-27" version="1">MVRNTEDENLKDLDFEEDFLRQFLRQSKYDVLRSFKRLQSFVKFRRQNKNVFKNVENVSKSPDYQFCTPLPWRCRDGCTITLFEYSKWSPKGITFEDLFRLGMILNHQSLRHPLTQINGFKMIVDFKGSDFEHLKFIPPSSLFTFYKAFITCTPARNKEIHLVNESFVWRAIWAFFKHIISDKLRKRIFLHSCPEDLLNYFPKHCLPVQYGGDLEDYYMEDWMKKANDQQGISTLAGQPNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAV0</accession>
    <name>A0AAV6VAV0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_023728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000120">
        <property type="protein sequence ID" value="KAG8193476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAV0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="6">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8193476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="331" mass="38077" checksum="BE7EA853C1F5FF6F" modified="2024-11-27" version="1">MIARPLHRLTEKQQKFTWTPECDEAFDHLKSVLTSAPILAYPEPDRMFILDTDASKECIGAVLSQEVDGKERVIAYFSKSLSKPERNYCVTRKELLAIVKAVEHFHHYLYGRRFLVRTDHASLTWLLNFKFPEGQIARWNQRLQECDIKIEYRKGSSHGNADSLSRRPCPETCKHCTNAESKYGYEQPMVRLVNISSLPDPDPWSDAGMRESQLEDQDLRPILESLEKAEGRPSWQDMASHGPVTKNYWALWDSLKLRNGVLYRKCESDDGRSFRLQLVVPRSRVENVLEELHSSPSGRVWGQNIAAEISRDKISPDIISRAKISRAHNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBA1</accession>
    <name>A0AAV6VBA1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000110">
        <property type="protein sequence ID" value="KAG8194040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBA1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8194040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="105" mass="11774" checksum="D76317FF7DEA25F0" modified="2024-11-27" version="1">MTLVSVSTRGFYYLVFVFAKLLLEGYEPRFNELKRRILEVIPNATVRGAVGRQSSYEITINDVEVFSKLKVGKFPQIDVVIQSAQAADAGEEPSEITETERCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VBN5</accession>
    <name>A0AAV6VBN5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_003038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000109">
        <property type="protein sequence ID" value="KAG8194095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VBN5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000437">
        <property type="entry name" value="Beat-IIIc, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="127"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8194095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="261" mass="29159" checksum="E6F97C1D3AED6555" modified="2024-11-27" version="1">MSLRASWCRSVRVTELVVPPSVVLGDSVRLACSYELGSEELYVVKWYKDDLEFYRYEPKDSNQAVYFPQPGIDMDLSRSNSNVVFLRTVALDTAGSYKCQVSTDAPTYSCVQAVKDMNVIILPLEGPRISGGRQSYDFGDNMTLNCTSAESKPAATLSWLLNGRPIPDASTVDHGVKADSNKLQVSSKSLHLQVTERLFQKGKATLECEASFQGEAVMISREITMLEINISLPWRCQKSLLLLSLLLPMVFLKRFFDCFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCN5</accession>
    <name>A0AAV6VCN5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000122">
        <property type="protein sequence ID" value="KAG8193411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCN5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8193411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="110" mass="12817" checksum="BF5AFF30F1368C61" modified="2024-11-27" version="1">MKMEKIPKTQMLEKKNVTPLGEKEKSDDLKARTEVASDMTEMWLASVPRHKTENIRDRYIRGVLQVKRVKQRVWDDGRQRGLRIRNIWLVVIARDKAVSQDQDASCPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VCW0</accession>
    <name>A0AAV6VCW0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000104">
        <property type="protein sequence ID" value="KAG8194347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VCW0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8194347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="119" mass="14513" checksum="9E766401773CA3A6" modified="2024-11-27" version="1">MSSKNPSMRHENKTRAKAFSSIEHISIKDVFFFRKERALVLYYIEDPKKNYVEDPKKNYVEDSKKTMLKTQRRTMLKTKEELCWRPKKNYVEDPKKNYIENPKKNYVEDQRITMLKTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDX8</accession>
    <name>A0AAV6VDX8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_002392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000107">
        <property type="protein sequence ID" value="KAG8194188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDX8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8194188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="141" mass="15525" checksum="CE56D3E6C57CD9FE" modified="2024-11-27" version="1">MNYVLFVTGVTMLAGSLFIVFLCKYCMRKKNIKKHTDDKIQKVHPIRPTVSSIVDGDSKTSEYLKSLSPNPSPNFPHKNSSRISVTSIGSGDSKEILLTPKSPRFLAVPGGPRPAIFPRPIPSIYIDTGCYSNPDEDAVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDZ0</accession>
    <name>A0AAV6VDZ0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_017268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000098">
        <property type="protein sequence ID" value="KAG8194830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDZ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8194830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="516" mass="58443" checksum="B91AB7E6D85081A8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGQ8</accession>
    <name>A0AAV6VGQ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="9">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_027972</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000091">
        <property type="protein sequence ID" value="KAG8195231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGQ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="11">
        <location>
            <begin position="215"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8195231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="573" mass="64939" checksum="761162D3F06B590B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHW6</accession>
    <name>A0AAV6VHW6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_017903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000083">
        <property type="protein sequence ID" value="KAG8195605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHW6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026085">
        <property type="entry name" value="ATF7-int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056565">
        <property type="entry name" value="Fn3_ATF7IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23210">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 7 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23210:SF26">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 7-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16794">
        <property type="entry name" value="fn3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="256"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8195605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="366" mass="40891" checksum="3A657400F604D380" modified="2024-11-27" version="1">MEATVKKAGAVEIKQEPIEQDEATPAQEEPKIDKKEETQISIIPKGPNFAYLITTDEEDLADVEGPDTLIMTAEEIRNYIEKSVFEEIINNNPMDVINSNAGELLQRMKAQRDEFSKLAKLVGIIEKNQEEFLRSKLKGSFTKDVSSSVDLPPLPRSQTNGAVSKQGVVTPSPNDKIIYPSSKVKATDAPSTSGQQQVQKPMPDIECIDLTDETEAPAKPAEPVKKNQPAYSFLGMVKHPAPLPPKPFAPLDKNLPPLPPKPRLKISSEERGIVLQWDMAPNTPDNRNYAPLTTFDIFGYQEQKNITINTLLWKKIGSVKAMALPMACTLTQFIEGHKYHFAVRAMDEHNRYGFYSDPISITYQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHZ0</accession>
    <name>A0AAV6VHZ0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000071">
        <property type="protein sequence ID" value="KAG8196377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHZ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF3">
        <property type="entry name" value="AT07710P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="458" mass="50079" checksum="0D974380D577191A" modified="2024-11-27" version="1">MQRILEVEPYINATVERPFAEALAEAKEADALVASGNYTREQLALDKPLLGVPFSVKGLLKVKNLQCTSGSLLFKDHIATEDSTSVELMKKAGAIVIATTNCPEFGMDLETNNRVHGKTCNPYGVNRTPGGSSGGESALVGAAGSVIGIGNDLIGSIRVPCHFTGIYGHKPTMGLVSNGGVVPNPHPGMEMFISTGPMCRYAEDLIASMKVLSTHEETRLKFGKSVNFKKIKICYMTQIQSPLVAPVDSEILGGLKKAISYFETTYDVTSKEINVPLLYDTNRCVCSHISSPEDLKETEDLKEVMTQGKASHINVKTDLLKYLVGKSTFTRGPLVVMNFVRSSPLFNKNKTEFYKQMLNKLAKEFDHLLDEDTVLLMPTLPTSAPYHTEMMAYIPSTCYTSIFNILGLPSTQCPLGINRDGLPFGIQIVGRKYNDPLTIACAIEIRKEFGGWVQPGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIK1</accession>
    <name>A0AAV6VIK1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000076">
        <property type="protein sequence ID" value="KAG8195860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIK1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11329" checksum="8EB4A446C1B80FAB" modified="2024-11-27" version="1" fragment="single">NAVDKDVVESLERLALVDFSTDAGIKRLEQSIKFADKLMEVDTSGVEPLISTVYDRNDNLREDETNDKSYRKELMNIAPVSEEFYYVAPSGTYTKKQADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VK30</accession>
    <name>A0AAV6VK30_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000075">
        <property type="protein sequence ID" value="KAG8196006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VK30"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="159" mass="17864" checksum="8E4B06B99609F192" modified="2024-11-27" version="1">MAKKFSQDTCLSNVIDLTYEESQSLLSDGKLKSKTENCNVLEILQNDTQGLIVLNNYKSVKTLSHSLRKKMVDVLVNFCIKTYGRLTNADFEILSILIVEEFPSEDQEIYYVPPCKDGQGPKISSGKIPNKYRNLVRLLKDAEVIPSKPKTICGSCGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKE8</accession>
    <name>A0AAV6VKE8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000069">
        <property type="protein sequence ID" value="KAG8196520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKE8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10691" checksum="BD2B243C98E80DCA" modified="2024-11-27" version="1">MQKITETQLIHSTTRTHSDHPMCNAQKSDALAEYAHLFAVGQAKHILQGSKWAFTCHKRGRERRNGYYFSQLYPGLPIGDFGIHTYREKMPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKN0</accession>
    <name>A0AAV6VKN0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_011352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TSC-22/Dip/Bun family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000058">
        <property type="protein sequence ID" value="KAG8197197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKN0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.490:FF:000002">
        <property type="entry name" value="TSC22 domain family, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047862">
        <property type="entry name" value="TSC22/BUN_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46745">
        <property type="entry name" value="TSC22 DOMAIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46745:SF1">
        <property type="entry name" value="TSC22 DOMAIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01289">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8197197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="167" mass="18110" checksum="545ECDB0A5DF86A9" modified="2024-11-27" version="1">MVQVSVVDSSSQQAKVEGKLHRRNNVVGAPLPTHWDLSFSENSLLSVYCFIKNFIGSQTAPEKLPSEVGPEVDPSTGSAAPTGANTVAIDNKIEQAMDLVKSHLMFAVREEVEVLKEKITELLERISQLEHENDILRANASAETLKQLNNRKKSSAGGTTLSSPPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VNB3</accession>
    <name>A0AAV6VNB3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000058">
        <property type="protein sequence ID" value="KAG8197208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VNB3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="9219" checksum="889B9D392D4C163F" modified="2024-11-27" version="1">MTERKGLLFSSFIYEDSSSSWTYSIGAPANKDGESGCFGKSAVLRYELFSSASSVNWNRNFVRLLWKFEISYLRTTQENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQE5</accession>
    <name>A0AAV6VQE5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_001648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000052">
        <property type="protein sequence ID" value="KAG8197726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQE5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04317">
        <property type="entry name" value="EcAspRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047089">
        <property type="entry name" value="Asp-tRNA-ligase_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001750">
        <property type="entry name" value="PRK00476.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="GAD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="168"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8197726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="616" mass="70527" checksum="210D462D6419C735" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQK6</accession>
    <name>A0AAV6VQK6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_016229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000031">
        <property type="protein sequence ID" value="KAG8199092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQK6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="3">
        <location>
            <begin position="187"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8199092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="320" mass="36052" checksum="0782C18E9452F790" modified="2024-11-27" version="1">MDFLSHFNLLVDSKNRKLIDGTTLLEAKGIPSFHLDDKIPIVNAVQEPYKDILEEFLDLLQLNVVNNKVREHNVEHYIETKGPPVFAKARRLSAEKLKAAKKEFEFMLQMGLCRPSKSNWSSPLHLVAKKSGDWRPCGDYRSLNNVTIPDRYPLPFLTDCSYILAGTTVFTSLVYGIKKGSKKEVIWTEESKNAFQLLKEALSQAANLTHPSEKAEISLTTDASDTAIGAVLHQTENQKKSPMSLFSRTLTPTQRKLKPCFTLHENSEQSKTDASSTAAMDPPPTPCPNKSDELLPEGESYTTRRGRKVKFPKHLEHYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRI0</accession>
    <name>A0AAV6VRI0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_003690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000029">
        <property type="protein sequence ID" value="KAG8199267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRI0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="72"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8199267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="523" mass="58567" checksum="C8C6F9ABFDE1EB3E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT52</accession>
    <name>A0AAV6VT52_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000023">
        <property type="protein sequence ID" value="KAG8199867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT52"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="117" mass="13439" checksum="D9064E1B7B7FC6CE" modified="2024-11-27" version="1">MRENFITQNGEFPSLLAKTHLDTTVLTNEDVSQQPRTSALHVAWAFDDWLTVSAYITDKLFLESSLTNHDKLSKERLCPSSILKPLRRRWEGLLFVTLRARRGECDVTHPSPEDAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VV41</accession>
    <name>A0AAV6VV41_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="11">ATase</shortName>
            <ecNumber evidence="3 11">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_000599</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:14907"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 11"/>
    <dbReference type="EMBL" id="JAFNEN010000015">
        <property type="protein sequence ID" value="KAG8200524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VV41"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="16"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8200524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="501" mass="54725" checksum="E1BD31F23385246E" modified="2024-11-27" version="1">MSLAEDERSEELHDACGLFGCVATDAWPTNLDVAHIIYLGMIALQHRGQESCGIATTNGSPDVVAVRRNAGLVNHAFTEDDLINLKGNLGIGHTRYSTTGGTDHGNTQPFVVNTEHGKLAVAHNGELVNAAVLRREIIKQGTGLSTESDSELMVQILCKAPSDPEHEKDGPDWPARIKYLMTKTKTAYSLLIMNGDKIYAVRDPYGIRPLCVGKLIPPRGSLVATETDSECDGFIVSSESCAFPSVSGRLLREVEPGEIVEISKEGIKSICIIPRPNNDMPALCIFEYVYFARPDSIMEGQMIYSVRMECGRQLARQAPIEADLVSVVPETATPAAIGYAQESGISFTEVLNKNRYIGRTFIQPSTRLRQLAVLKKFGPLQDNFKGKRIILVDDSIVRGNTIGAIIRLLREAGASEVHIRIASPPLHFPCYMGINIPTKEELIANFSNAEQLAQQIGADSLVYLTVENLESAVRKHAKTNGKPVGHCTACLTGNYPVELQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VX34</accession>
    <name>A0AAV6VX34_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 203</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000016">
        <property type="protein sequence ID" value="KAG8200372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VX34"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22816">
        <property type="entry name" value="TMEM203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF9">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10269">
        <property type="entry name" value="Tmemb_185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8200372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15582" checksum="218C1C9A3EFE40E0" modified="2024-11-27" version="1">MIFTLRELVRWLGLTMIEILLNLVAVTVFSVMATFKLEQIVTMSWWSTFIPLFLCDGLNAYFCVIVFIRQYLEGLYKAAALRSSWSFIQLLLVFLFKLLLCLKLEGQKNLVYSEVLSPLFILLMLIMVRACQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VX80</accession>
    <name>A0AAV6VX80_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000016">
        <property type="protein sequence ID" value="KAG8200334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VX80"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="101" mass="11643" checksum="0C1E190A9D178371" modified="2024-11-27" version="1">MEHLLNPTEHLQLSPDSCLMFHDRVFPPCPLSRNHYLTSIGLDSGSARQQKILPPDIARILHRSISDLEEPCKFICLKKKIFFFFKNVTGPFYYGDFCRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TCY7</accession>
    <name>A0AAV6TCY7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006604">
        <property type="protein sequence ID" value="KAG8155784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TCY7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8155784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="14194" checksum="9E92CB4C522235FA" modified="2024-11-27" version="1">MHHLPHESRKKLLICQSSPCPGLGRFAALIKLNRNPHYWCYRGAGYLALPSNWIIAKDLECTHSNYWSQKVPYRYFFVHYHPRFRELVFGAPAACPWMVVSVSRLPFAESTPDSPVTLYVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFC1</accession>
    <name>A0AAV6TFC1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015260</name>
        <name evidence="2" type="ORF">JTE90_017575</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005477">
        <property type="protein sequence ID" value="KAG8170432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010002652">
        <property type="protein sequence ID" value="KAG8172494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFC1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="182" mass="21744" checksum="CBF63271C578521E" modified="2024-11-27" version="1">MDYVLDRQCGVPLYYHRDTCKPFDGDLIEFVRGETVCVPMPRDQFANYIGAFFLERSHPASSLHVNGQWKKGAGGGQASFSFPLWGPRDNISYILNAEDWMMELYRYDPFQMCQDMLDWTKPYRFDLVRDHYVRLRFLRPVDMTESRHWSLLTQLQKDSFKQLANRILKERDWTPTKLYFCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFI9</accession>
    <name>A0AAV6TFI9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_006520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005845">
        <property type="protein sequence ID" value="KAG8160091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFI9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF101">
        <property type="entry name" value="ZWEI IG DOMAIN PROTEIN ZIG-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="63"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8160091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="166" mass="18162" checksum="69A0ED97EA55B511" modified="2024-11-27" version="1">MLTVTNEFIDMKLIHGNEVEFSNGLLQLSPVSDNDSGIYECLASNGITPDIRSNFTITIRDIPRIQPFSFPENIVEGSMVSVTCISPTKTKPVHFSWSKNDIQITPNEDNIKISSTNDVSVLILNPVTLENSGNYSCSATNSEGSDTFSTTLNVKASPKCKSSPWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TGD0</accession>
    <name>A0AAV6TGD0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004722">
        <property type="protein sequence ID" value="KAG8170884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TGD0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="177" mass="19508" checksum="6D4B770DD158FA06" modified="2024-11-27" version="1">MNSVPISDEPFQGHELLQRKKNSSPGPRSTSPSFGCVTALGPKDYLRVRWGILTPFPFGRQRDKTRCVCVSADVLASPPPPERISRSLGPTAHVQLLSHGNPSAASVLKDSHLSIWLLPQICTGGGSRRLHARHLQRTPRDPPTHCVKTHEGKLCRSGRLCPTLERHPFSGLRCFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIA4</accession>
    <name>A0AAV6TIA4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004062">
        <property type="protein sequence ID" value="KAG8171381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIA4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="113" mass="11825" checksum="E81CB78E05B01F0B" modified="2024-11-27" version="1">MDVEGKGRGRSSNGGRGSGRSAMGGRGSGRSTMDVEGKGTGRSSNGGPGVEDPAMEGRAWKIQQWGPGQGKIHPMEAEAVEDAAGFLFLLIGKTVVAFFRPVLIAHDRQNLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKM4</accession>
    <name>A0AAV6TKM4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002647">
        <property type="protein sequence ID" value="KAG8172512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKM4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="193" mass="20628" checksum="82568172E6AABED4" modified="2024-11-27" version="1">MPRGPPKRNTTTVSKKRVRGGQAESGFAGLGPGFDPLRIQYQTPEKRPGGAPTWPRTADPVPKLLGIPVNHKTPVSKNDEWAPTRRLGASPGSPSSAPLGIQCQPPKKNTRRENLATNGLAPALECRRKIVSKKHSPSPTGQRLASVFLGFSGGFQPALRPNQPRDDKGGKTSGRSLIGSIVPDSTTGLEYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TMP9</accession>
    <name>A0AAV6TMP9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_010128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002320">
        <property type="protein sequence ID" value="KAG8172826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TMP9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13897">
        <property type="entry name" value="GOLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="2">
        <location>
            <begin position="83"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8172826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22950" checksum="9236DD500A8B9470" modified="2024-11-27" version="1">MAFPIVKAILSGAVIDKIKVFGKEGWKEELLELIDADVLPAFLGGNRTDPDENPKCNTIVNHAGYIPEHYYLTKNVGNIQKKANCQSCCLDRHKRAEVLVEVAEPGSVLHWEFETKYYDIGFGIYKNSSDSDYPVDLIPVHKVDTENKPETGMLRCKSAGTYVIVFDNSYSWFHSKVIYYRTWITKPVEEENSDDFITIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TN90</accession>
    <name>A0AAV6TN90_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_005600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002209">
        <property type="protein sequence ID" value="KAG8172951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TN90"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000017">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000104">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF14">
        <property type="entry name" value="CELL ADHESION MOLECULE DSCAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="107"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="209"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="298"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8172951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="410" mass="45341" checksum="509DCA045A66E6FB" modified="2024-11-27" version="1">MIFVKKSQASDVNLKIQSFIFPATPIIGQRVNTMCATVIATDKMEFYWSKNGSDLKKSNRVQIMAFPQFSSLIIDPLVEEDSGNYTCTVMSKGTSDTYTAALNVLTPPVWIHKPVDSEGNSGESILLNCEGLGKPRPSSKWTKLSGIDKEVKTLENTENIHIHLNGSLEIRQIDKETEGYYQCIVSNGVGTELKKDVNIKVIDTWKVQPFTFLNGSKIGQRISTTCTTTGGKNPNFEWLKDGKDLKEGPTIKFITMSGVSTIIIEPISESDTGNYTCVAKSEGISDAFTATLNVNVPPEWLTTPSDKEALSDDTVIMTCETTGKPKPITTWEKYNDMDGKYYPIVSDSAAHQNRIFFLKNGSLKITELNKGDEGIYQCVVSNDIGESLTKSATLRVIGENLSCCKNMFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNE1</accession>
    <name>A0AAV6TNE1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_016277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010001855">
        <property type="protein sequence ID" value="KAG8173350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNE1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="61"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8173350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="402" mass="45691" checksum="73648A25D58C3954" modified="2024-11-27" version="1" fragment="single">MKICHEVTAAHLGATKTKDTLFKTFYWPNCYKDVDNFVKTCDVCQRAGKSQDKKKAPLKLVLVIPEIFSKINVDACGPLPQTPSGNRYLITALCMSSKYPDAIPVENLRSKTIVDVLLQIFSRMGFPKVLQTEQGTSFMSALTTEFLRGFGIKVVRSSVYHPQSNPVERMHRTLKRILRVLCLESGPDWEKILPQALFALRTATHGSTGFSPAELVHGRNLRTSLMLLYEQLTEETQEEDSVVSYVFELMNRMKRCQELAVHNMQEAKEKQKICIFSNQPGCTDLAEHDIELESESPIIAIPYRMTPRQSDILKAEVNKMLEMKVTEPGDSDFTSPMILVEAPGKDPRPCIDYRRLNKVTRTQFFPIPNIEQLIEKVAASKYISVLDLIRGYWQIPLSKQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TP25</accession>
    <name>A0AAV6TP25_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_013417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001870">
        <property type="protein sequence ID" value="KAG8173334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TP25"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8173334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="8869" checksum="E3A5FC7271EB7ED4" modified="2024-11-27" version="1" fragment="single">LYLGRKYAVVCNDYEAVKEALSKTEAITRPVGIFSPIPLGTGFGSANVHDWSVQRRFCVKSMKDDGLGAGHEWEELLQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TP72</accession>
    <name>A0AAV6TP72_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001635">
        <property type="protein sequence ID" value="KAG8173573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TP72"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="9040" checksum="20F977FD584D0969" modified="2024-11-27" version="1">MTKQKKRNAHNSYSQQRTNGGLDWAKCLIVEHPSHGGRRYKTNKAINKQSSLILECLKPWSFSRPSMGHKPIDLVTVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQ47</accession>
    <name>A0AAV6TQ47_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001529">
        <property type="protein sequence ID" value="KAG8173709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQ47"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="107" mass="12272" checksum="7C58B69C2C40A1A0" modified="2024-11-27" version="1">MFRNTGNRSVSKQCEYSDSECYKPTTQQRQSRQINDCRRAKNTCSCQNIGRNRFGSDSRGCRTVGKIKMPGRQDQWRQAIEAENPSPLHFHIWSVADKIILPLGQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TQU6</accession>
    <name>A0AAV6TQU6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014545</name>
        <name evidence="3" type="ORF">JTE90_028673</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001495">
        <property type="protein sequence ID" value="KAG8173780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFNEN010001486">
        <property type="protein sequence ID" value="KAG8173792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TQU6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8173792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="102" mass="11729" checksum="DD1BF846C8C0FDEE" modified="2024-11-27" version="1">MKDFQHVSSEQESQLISRIQEQKKPLFRLVQIRLSTKSNAYESCEKTRGGEEQSTCVEAGPDSRQGSGLRAHETPTLYFMGCAVEILREKSKFFHLFFPETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRH9</accession>
    <name>A0AAV6TRH9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_018595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001198">
        <property type="protein sequence ID" value="KAG8174505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRH9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8174505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="174" mass="20202" checksum="73FCDC34CB5CD5E5" modified="2024-11-27" version="1">MPYTSPRSPTINRTDEESQPLIHKEDDEDGKLFQRIVMAALLITAVAMIAIGHIYLFDCNVQPYIPIFLLVGGYSSILKCQLSLVMGCCWKNNTACKIVNYWSYLMLLFMMVWFIVGSVWVYGVKKVDFEDTTSTAYCNKTLYYFSWWLLIIYWSLICNLSMQHDKRKTTSKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRT6</accession>
    <name>A0AAV6TRT6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_012177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001159">
        <property type="protein sequence ID" value="KAG8174732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRT6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="170" mass="19410" checksum="FF1B7434C8A5CE23" modified="2024-11-27" version="1">MTETSQWQHVASEDNPADLVSRGLEPSRLVNNELWWHGPSFIQSEIGGTPVRLNLHSSDVEYLEQETKTVMLVKEDSDFLGDILGISNCFDKIVRVLGFIFRFVSNCRGKKQQIVLHLGPLSTQELSNAKRHVVRLVQELKFKEDLAFTRSIRKYCFARKNEKSCKCGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTB1</accession>
    <name>A0AAV6TTB1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001048">
        <property type="protein sequence ID" value="KAG8175204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTB1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="249" mass="28911" checksum="531FA91A3B18F114" modified="2024-11-27" version="1">MAASKRVHFDETFNETISYPAEPLLTNPDLQDATDRLRIERQHPTELDKVRHLFQKCRDHDFMIVYGNLGRNPIILTYFLDLCFSAQESVGVLAPWSQYKTPYKVKTASHLDYVFVIEPYFGKHLVKFAKHVIVLTSHLSLTYPPSTPVYFLRVGRTNQAEPEQVKPKGSVFVPPAFHQNKLFHLQRWTHLDIQNAKSAHDAFMKLLTGRELIPEGPYTLDMSPRDDQIIRWHLEKTKQVFQDGNVHAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUR2</accession>
    <name>A0AAV6TUR2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_018041</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010001023">
        <property type="protein sequence ID" value="KAG8175361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUR2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8175361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="538" mass="61491" checksum="D21D570DA370CBDA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUU6</accession>
    <name>A0AAV6TUU6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_028224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000945">
        <property type="protein sequence ID" value="KAG8175872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUU6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8175872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28260" checksum="5220DC2360FE4DD7" modified="2024-11-27" version="1">MSVLVTGANSGIGLEFVRQLVQLEKYPRYVFAAYRSKGKIKELENIKKSSDRCQVILIQADVTNKEDVKSLRNSIEEIVGDKGLNMLINNAGALRIGSYGKLTEEDMLFHFKTNTVGPVTVFKEMLPLLVKGNESKPNGELFQVKVLNISSMAGSIGDLGEIPLELVESTISYRTSKAALNMAMRSIAIALKDKGILMVNMGPGYVITDKGSTSADVAESVSLTIDVPESVSAMLKTLPTLDQSRHGDFMDRHGRAIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUV1</accession>
    <name>A0AAV6TUV1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">ADP-ribosylation factor-like protein 2-binding protein</fullName>
            <shortName evidence="12">ARF-like 2-binding protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_021120</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role as an effector of the ADP-ribosylation factor-like protein 2, ARL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
            <location evidence="1 12">Cytoskeleton</location>
            <location evidence="1 12">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 12">Cytoplasm</location>
            <location evidence="3 12">Cytoskeleton</location>
            <location evidence="3 12">Microtubule organizing center</location>
            <location evidence="3 12">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the ARL2BP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001007">
        <property type="protein sequence ID" value="KAG8175423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUV1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051457">
        <property type="term" value="P:maintenance of protein location in nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1520.10">
        <property type="entry name" value="ADP-ribosylation factor-like 2-binding protein, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038849">
        <property type="entry name" value="ARL2BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023379">
        <property type="entry name" value="BART_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042541">
        <property type="entry name" value="BART_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15487">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15487:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11527">
        <property type="entry name" value="ARL2_Bind_BART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7 12" id="KW-0969">Cilium</keyword>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="BART" evidence="15">
        <location>
            <begin position="264"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF11527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8175423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="390" mass="44774" checksum="F369898C0C3D985E" modified="2024-11-27" version="1">MADDEAARRREIRQKKILESSEARLKRITSSCSKKIQDYSVCHGDNTGITEISKDRSTEKDDSLSAECSIKRRGENCSLYSGSNYLNESSSSNNQGAKPKLTENDYNRVNSSNGDRSLPDSYTFPKKVSDAETRSFGRTRTDARRNSTCTQIVMETLQFSALISLTNLRFWLVAMTAFTVKLYFLTLESLPIFQTVFFPFLMLELFIFSWSRLEPQVFSRPVSSTIISSVLLLCGLSSNVYTIFKKVMGDTEDLVCKSDDNCQFDTIIGYIEDIIIDPNFSSLQHNFMEQHYLKFEKCEENKLEYMEIFNTYTELIEKHIEESLIKRIPGFSMKEFLRDILNKQSELDGDVFDMLVSFTDFLSFKEMFLDYKAAKSGFTPDLSITCSKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TX30</accession>
    <name>A0AAV6TX30_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_026844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000863">
        <property type="protein sequence ID" value="KAG8176595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TX30"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG8176569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYN7</accession>
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        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7</fullName>
        </recommendedName>
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            <fullName evidence="14">Complex I-B14.5a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase subunit B14.5a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_026653</name>
    </gene>
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        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA7 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000882">
        <property type="protein sequence ID" value="KAG8176435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYN7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009947">
        <property type="entry name" value="NDUA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07347">
        <property type="entry name" value="CI-B14_5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8176435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="116" mass="13141" checksum="C76250F9DCA23827" modified="2024-11-27" version="1">MSKVAPRSLAPFLKWVRDFLLGREFVNSLRFQDFVATRSPPPPNLPEGPSHKLSNNYYFTRDGRHVARPPVVLLEDTKRKALIGGAKENAENKAVTGRKLGHVFPGKPYDWEQVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1R7</accession>
    <name>A0AAV6U1R7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000765">
        <property type="protein sequence ID" value="KAG8177646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1R7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26977" checksum="E9953E03E822E0CC" modified="2024-11-27" version="1">MLTNAKKDGLTYWTFGIEIYNPVLSWSLMFFGVYNFFAINTGCPCLIVLSMCLLIQQCVNILSAYERKLQGMAFGPNCFDTISDYFCAVEIVRLLNDTLSVPLFLAMIISLFDIFISISTFLLHSFEVPAILALEMALTSLTGIIILLSLTLYGSKITESLSKIKQTAGNLLVRNAKQKFELGIRNETVYLLRRIEKSEIIHLSPCGIIEIRKSFLLTAVGGLCTYGLLILNFKIKDIQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U208</accession>
    <name>A0AAV6U208_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_021160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000748">
        <property type="protein sequence ID" value="KAG8177828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U208"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001077">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF78">
        <property type="entry name" value="ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="27"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8177828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="625" mass="70002" checksum="1191E1BAB6DFC31E" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2A2</accession>
    <name>A0AAV6U2A2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_016289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000679">
        <property type="protein sequence ID" value="KAG8178627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2A2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8402" checksum="1BCC6A2E12923020" modified="2024-11-27" version="1">MIYTFAFHFSSSVAILGSLCVLWLCEFYLLLWLGSLAASVACLLYVSYQVGSFLDNFLSRFRVKSANKAVFITGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2C7</accession>
    <name>A0AAV6U2C7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_014706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000732">
        <property type="protein sequence ID" value="KAG8177963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2C7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974:SF2">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8177963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="377" mass="43134" checksum="F690E389B2F4CE60" modified="2024-11-27" version="1">MGCGSSKHASLRENPDKPQKRIVEESGDVDVGMVIPEKGAAQIKPVEITVETLQKYLDLEKGIQGFEKRHVLDNYQLKAEQMDQLEKNLKALQDSKDLQSQNLHKLQCSLDETNGSQSLKQFLFEKSQKGEPLNEDQEEYVDLLNKQEVLVRQIESTSKQKDELKEEVASLVIDGELVQKLYAQRDELLDAIFGGAYGSALENRLEKETDLLLERLNHVRQAHFKWKQAHGMVRKACAQLGTAVHKWKELANIPDNDMEQRYYHAAETRNNLVAASQNLQGAQEFLPNITFPYCDEDEVTTLNKAVTFIFTDMQTPERYEHALNCYHTTYRRSGALRQWFDQKKNNDRKAMFPWLPANVLPPVKALTVHKWALPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5Q8</accession>
    <name>A0AAV6U5Q8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000633">
        <property type="protein sequence ID" value="KAG8179359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5Q8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043552009" evidence="1">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="155" mass="18320" checksum="4D8C401218ACADF5" modified="2024-11-27" version="1">MKHMWMLFLCLTITIKLDEEFFNCDVGNTWEDGITKYEVISYGEKLYVVAACAKEEFIIDRDTSSIRCDNRTSNRVLPQCRKGEVKNLFDACATGRRSRSDDYEFENVWHHGALYVRVFCIHEGIETRSDRILCENGKMNRTPPIDFCYEPYFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U600</accession>
    <name>A0AAV6U600_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000651">
        <property type="protein sequence ID" value="KAG8179060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U600"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="563"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="610" mass="71125" checksum="6F3549DA52955C7F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U638</accession>
    <name>A0AAV6U638_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000614">
        <property type="protein sequence ID" value="KAG8179609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U638"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="12213" checksum="2FD5826ED6B60708" modified="2024-11-27" version="1">MLDDIYEGYKVHQYWFILTSMTEDPEILATDYQGMVKIRKYWPLDYRGGVKIRKYWPLDYRGRVKIRKYWPLDYRGGVKIRKYCPLDYRGRVKIRNTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6N0</accession>
    <name>A0AAV6U6N0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Histone deacetylase</fullName>
            <ecNumber evidence="2 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_025971</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 11"/>
    <dbReference type="EMBL" id="JAFNEN010000601">
        <property type="protein sequence ID" value="KAG8179804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U6N0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000003">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="16">
        <location>
            <begin position="26"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="389"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8179804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="479" mass="54484" checksum="8FD86946D71C60B5" modified="2024-11-27" version="1">MTAPIKKRVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLILNYGLYRKMEIYRPHKATQEEMTKYHSDDYVRFLRSIRPDNMGEYNKQMQRFNVGEDCPVFDGLYEFCQLSTGGSVAGAVKLNKQAAEIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTASFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPLRDGIDDDSYEQGIFQPLISKVMEMYQPSAIVLQCGADSLSGDRLGCFNLTLKGHGKCVEFVKKYNLPLLLLGGGGYTIRNVARCWTHETSVALNSEVANELPYNDYFEYFGPDFKLHISPSNMANQNTPEYLEKIRTRLFENLRMLPHAPGVQMQPIPEDAIDQESEDEDKENPDERISIRASEKRIACDEEFSDSEDEGDGRRDNRSHRPNKKKHKVVPEEEGAKKEATDIKAEREDKKPDAAAADNKGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7K1</accession>
    <name>A0AAV6U7K1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000601">
        <property type="protein sequence ID" value="KAG8179813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7K1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="210" mass="24560" checksum="3EE279AF08737A75" modified="2024-11-27" version="1">MPKSICVVPGYAVILPIISQEHEQTHDEQLKFNNDNDTVKNIENRKTPERRWKCPTCKFNRNAHYRDSGGEERAAGLSTAEQRQDPSFSDQSYQHRQRTANYANKLKDRTSSYAMRKEKNYHHREDIVHEANPYFLKIFIVPSTPNKEQPNQNLRKNKDHVKKYGKTIGSSQNNKDSRRRVMIKCEADISMGCHGNCELNQDYCEQDKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U7Z2</accession>
    <name>A0AAV6U7Z2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_023360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000581">
        <property type="protein sequence ID" value="KAG8180152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U7Z2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="552"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8180152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="805" mass="94210" checksum="552E6D57B0CFB93F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8X6</accession>
    <name>A0AAV6U8X6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Succinyl-CoA:glutarate CoA-transferase</fullName>
            <ecNumber evidence="14">2.8.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase SUGCT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Succinate--hydroxymethylglutarate CoA-transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_025364</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Coenzyme A (CoA) transferase that reversibly catalyzes the transfer of a CoA moiety from a dicarboxyl-CoA to a dicarboxylate in a metabolite recycling process. Displays preference for succinyl-CoA and glutarate-CoA as dicarboxyl-CoA donors and glutarate, succinate, adipate/hexanedioate, itaconate and 3-hydroxy-3-methylglutarate as dicarboxylate acceptors. Acts on intermediates or end products of lysine and tryptophan degradation pathway, in particular catalyzes succinyl-CoA-dependent reesterification of free glutarate into glutaryl-CoA to prevent renal excretion of glutarate. Upon inflammation, may convert macrophage-derived itaconate to itaconyl-CoA in erythroid precursors where it negatively regulates the TCA cycle and heme synthesis to limit erythroid differentiation in the context of stress erythropoiesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate</text>
            <dbReference type="Rhea" id="RHEA:81723"/>
            <dbReference type="ChEBI" id="CHEBI:17325"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:81724"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:81725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:12284"/>
            <dbReference type="ChEBI" id="CHEBI:17325"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="2.8.3.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:12285"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:12286"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>glutarate + succinyl-CoA = glutaryl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:67900"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67901"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:67902"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate</text>
            <dbReference type="Rhea" id="RHEA:81711"/>
            <dbReference type="ChEBI" id="CHEBI:17128"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:76327"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:81712"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:81713"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>itaconate + glutaryl-CoA = itaconyl-CoA + glutarate</text>
            <dbReference type="Rhea" id="RHEA:81715"/>
            <dbReference type="ChEBI" id="CHEBI:17240"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57381"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:81716"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:81717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>itaconate + succinyl-CoA = itaconyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:38283"/>
            <dbReference type="ChEBI" id="CHEBI:17240"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57381"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:38284"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:38285"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.13" evidence="14"/>
    <dbReference type="EMBL" id="JAFNEN010000558">
        <property type="protein sequence ID" value="KAG8180659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8X6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10540:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.10:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8180659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="421" mass="46347" checksum="D4A9DC3A8AC74879" modified="2024-11-27" version="1">MKLWNYQQVFHHQLRTLCSKSIETSQGPLSGIRVLDLTRILAGPYCTMLLGDLGAEIIKVESPGGGDETRKWGPPFVNGESAYFLSINRNKKSIVVDMKNSQGSNLIKELAVKSDVLVENYIPDKLKKFGLDFQSLHAVAPHLVYCSITGYGSTGPYSSRPGYDVIAASIGGLLNITGPQSGDPCKVGVAVTDLATGLYAHGAIMAALLQRSKTGRGQKIDCNLLSTQVSLLANIGSNYLNAGWEAKRWGTAHESIVPYQSFKTKDGFLTIGAGSDKQFKELCEILNVTQFLEDPKFQTNKDRVENRKELVSVLTKIFSSKTNDHWLKLFESSSIPCGPVNKMKDVFTDPQVIYNDMINNMNHPSAGHIKLAGPAVKYSESVNMARSPPPCLAQHTNEILSSVLQYKEDYIEHLRNCKVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UAJ8</accession>
    <name>A0AAV6UAJ8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleocapsid protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000559">
        <property type="protein sequence ID" value="KAG8180560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UAJ8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="88530" checksum="C2884D7671042BDD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBE8</accession>
    <name>A0AAV6UBE8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_009825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPPC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000502">
        <property type="protein sequence ID" value="KAG8181665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBE8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055428">
        <property type="entry name" value="TRAPPC13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23643">
        <property type="entry name" value="TRAPPC13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="4">
        <location>
            <begin position="173"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 C-terminal" evidence="3">
        <location>
            <begin position="315"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8181665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="48727" checksum="F083DBBF8BB7906D" modified="2024-11-27" version="1">MDTREKEHLLALKVMRLTRPSLYTTQPLATDSKYFACNILNKELKDDLGSPSNLEYCNSGKMLMLPQSFGNIYLGETFSCYMSVHNDSQQVVTAVQVQADLQIGMQKIVLSGQRGNYSSFTQLNPDESVDDVILHEVKEIGTHILACTVNYTTMHNEKLHFRKFFKFQVSKPLDVKTKFYNAEDYIVEKSDEVYLEAPLQNITFASMCLEKVSLEPSNNFTSNQLNVVQIDAETMPVFGDVSCLNPNDSMQYLFCLQPKPGTQTYSKLVKNVASIGKLDIVWRTCMGERGRLQTSQLERMAPGYGEIRLIITEIPSIVSLEKPFPVTIKIINACDRSLDLLLSLKNSFSNGILWHGISGQKFNNLEKGAFVTVSLEAIPVRPGLQGVSGLVVKELFLKRIYNFVDITQVFVTTSDIYKDNSNSLVNSKLNVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBR5</accession>
    <name>A0AAV6UBR5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Hedgehog protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_009827</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product. Once cleaved, the C-product has no signaling activity and diffuses from the cell.</text>
    </comment>
    <comment type="function">
        <molecule>Protein hedgehog N-product</molecule>
        <text evidence="18">The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.</text>
    </comment>
    <comment type="function">
        <molecule>Protein hedgehog</molecule>
        <text evidence="18">The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>glycyl-L-cysteinyl-[protein] + cholesterol + H(+) = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:59504"/>
            <dbReference type="Rhea" id="RHEA-COMP:12707"/>
            <dbReference type="Rhea" id="RHEA-COMP:15369"/>
            <dbReference type="Rhea" id="RHEA-COMP:15374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:65250"/>
            <dbReference type="ChEBI" id="CHEBI:143135"/>
            <dbReference type="ChEBI" id="CHEBI:143140"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:59505"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <molecule>Sonic hedgehog protein</molecule>
        <subcellularLocation>
            <location evidence="18">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="subcellular location">
        <molecule>Protein hedgehog N-product</molecule>
        <subcellularLocation>
            <location evidence="18">Cell membrane</location>
            <topology evidence="18">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 18">Belongs to the hedgehog family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000502">
        <property type="protein sequence ID" value="KAG8181667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBR5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016015">
        <property type="term" value="F:morphogen activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007367">
        <property type="term" value="P:segment polarity determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.16.10:FF:000001">
        <property type="entry name" value="Indian hedgehog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.10:FF:000005">
        <property type="entry name" value="Sonic hedgehog signaling molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001657">
        <property type="entry name" value="Hedgehog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001767">
        <property type="entry name" value="Hedgehog_Hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050387">
        <property type="entry name" value="Hedgehog_Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000320">
        <property type="entry name" value="Hedgehog_signalling_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Zn_M74/Hedgehog-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11889">
        <property type="entry name" value="HEDGEHOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11889:SF31">
        <property type="entry name" value="PROTEIN HEDGEHOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01085">
        <property type="entry name" value="HH_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01079">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00632">
        <property type="entry name" value="SONICHHOG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="Hedgehog/DD-peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 18" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 18" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0504">Morphogen</keyword>
    <keyword evidence="13" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4 18" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0709">Segmentation polarity protein</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hint" evidence="20">
        <location>
            <begin position="181"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Hint" evidence="19">
        <location>
            <begin position="289"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU280812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8181667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="399" mass="44999" checksum="13F738B1670E0639" modified="2024-11-27" version="1">MILELKACGPGSLYGNRRRFRRKLTPFVLKESFPDTSEFSVHASGPFLGALTVGQGKFLKLAPSYNKDIVFQDSEGNGEDHMMSLRCRDRLDILAVSVMNQFPGTRLRVLEAFDTEHIHKEKSLHYEGRAVDLSTSDRDRTKLGMLARLAVEAGFDYVYYKSKTHIHASVKVDIEDITRNGGCFPANASVDTPSGKKLMADLKIGEFVLSSTPDGTLVYSQVLLFLHREQNMNRVYNIITTEKNSKIVLTSSHLIFVTIDKSLTNISNSYVTFAKNVEVGHYLFVKNNSSGIELQKVVNITTVIENEHYAPLTEEGSIVVNDVLASCYAMIESHKIAHAVFTPIRLLLNSKKAAMHFLQLFTSEEDMSNKVEKPLGVHWYAALLYKMSYYLLSDNYMYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCA2</accession>
    <name>A0AAV6UCA2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PIF1/LRR1 pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_020132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000541">
        <property type="protein sequence ID" value="KAG8180901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCA2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057437">
        <property type="entry name" value="PIF1/LRR1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF52">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25344">
        <property type="entry name" value="PH_LRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PIF1/LRR1 pleckstrin homology" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8180901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="384" mass="43652" checksum="9BD00848E7101CE1" modified="2024-11-27" version="1">MKITCGVELVNRAHPAISARNKTKYSVATLALCHKLKQREMHSDKDVFLILCTHKNPRGAKYKIYNNVDKLFTKFINDGKATLRFKEPPHDLIISKADPLQLKGFLHGVGLTIVGQGTGRIRLSETPTKVDRPKQKLAIMQRSDLPGKKGFPESLTWLQIQSCKLKKIDLGVLKLVHLEVLDLAHNSLKELPLGLSQLKLKELILHHNELTSFPPQLATGILGQNVQVLDLSFNNIAELSPYFCLMRKVSVLSLKNNRLSKLPRNFHSLESLRMFSASHNELKVIPFGIRKLQLDTVLHQTIVEYDLPYTSHYIPSTLVDYIIEQCVCPCGKKVFQNTSSCILVLDLYKLASTVVYINNTGRFKVPLEVYFCSTKCWKKVHYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UCS6</accession>
    <name>A0AAV6UCS6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_014256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000509">
        <property type="protein sequence ID" value="KAG8181528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UCS6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8181528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8874" checksum="5D2199365DA466E2" modified="2024-11-27" version="1">MQSRLKSQRWMSPHIRERTMQNNTGLPQNSSPISTQIYPPEILRGTEQLLQSVRKGMGNYRARKTINRSEKKRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UEB4</accession>
    <name>A0AAV6UEB4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD repeat-containing protein 47</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_007306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000459">
        <property type="protein sequence ID" value="KAG8182569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UEB4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8182569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44535" checksum="5947D0C14354B155" modified="2024-11-27" version="1">MFAIPPCPYYMWPPQRIPGQWPVVASTLPAPARHCPMHDGASYKRPKDKLHRASSAPNGRKKLSGRSSSGSNEGGSGGFVAVTQLEDEQAIRCVEFHPTGKFYAVGSNTKALRICAYPSCRDVRPDQEPREPTVLQKRMKHHKGSIYCMAWNATGDLLATGSNDKTVKLLKFDPETCHMEDVSHPLTMHGGTVRDMCFMEDLSNRSNLLISGGSGDNKIYITDCETAMPFQALSGHTGQILSLYTWGGVMFVSSSQDKSIRFWDMRTRGCTHHIPAKAAGGTGPGSASATLSVDPSGRLLVSGHEDSTCMLYDMRGNRPLQTFRPHTADVRTARLSPKAFYLLTGSYDCKLMLTDLQGDLTQPLTSVRVAEHADKVIQGRWHPHDFTFLSTSADKTATLWAMPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UF92</accession>
    <name>A0AAV6UF92_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000433">
        <property type="protein sequence ID" value="KAG8183090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UF92"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043708978" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="8176" checksum="BC050ED19C9E8C94" modified="2024-11-27" version="1">MVHAVIIFVSVTISASLVHEAYDELRSEIRRSLVFSDALFTNEHLKFMICMDKDACLTVNKIVKIRRSFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGG8</accession>
    <name>A0AAV6UGG8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_019685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000454">
        <property type="protein sequence ID" value="KAG8182660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGG8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001136">
        <property type="entry name" value="Zinc finger protein 408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8182660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="241" mass="28061" checksum="7465578BBC542F6C" modified="2024-11-27" version="1">MTTHRPENKLICNVCNRQFVQKKNLISHEMIHKGERPFKCDVCEKGFTRKEDLKSHSYIHTGQTPHVCKICDKRFTRSPDLKRHMVTHAGGKKHACEVCDKQFTLLTDLNKHILVHTGESPHVCEFCHKQFTRGGDLKRHVLVHTGEKQFACKVCDMRFSRHDGLKDHFLTHTGAKPHVCAICSRQFGHMSYLRKHVLIHMRDKPCVCMLCDSKFTCDKDLQKHLLSHSTKILKEVDHEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UH35</accession>
    <name>A0AAV6UH35_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000437">
        <property type="protein sequence ID" value="KAG8182998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UH35"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="181" mass="19688" checksum="1EBEE3EDE72A7AB9" modified="2024-11-27" version="1">MTDLSLRSEHSIPTTAFVEFTRRFTLTFGSEKKNITDIHNPSIILEGSNNQPQIIYHTVLRSPYQLLFSKMTPYVVHDDDKADQVTNVPPQKPKSIMVTTNGYGNGLNGTTSNGSVANGPVVNNGQVVKGNGYANGHTNGHHGLEEEDVVESPDSLPSRSSVSGRSIIGNGKNGRSRELKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UH62</accession>
    <name>A0AAV6UH62_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">cGMP-dependent protein kinase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">JTE90_008304</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NRARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000419">
        <property type="protein sequence ID" value="KAG8183407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UH62"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000004">
        <property type="entry name" value="Phosphatase 1 regulatory subunit 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000898">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031775">
        <property type="entry name" value="PRKG1_interact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF21">
        <property type="entry name" value="MYOSIN BINDING SUBUNIT, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15898">
        <property type="entry name" value="PRKG1_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="12" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="14" id="KW-1053">Target membrane</keyword>
    <keyword evidence="9" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="cGMP-dependent protein kinase interacting" evidence="19">
        <location>
            <begin position="532"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="420"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="529"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF15898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG8183407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="653" mass="73067" checksum="E2FC06C7195F54D3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHB0</accession>
    <name>A0AAV6UHB0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein kinase DCLK2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">CaMK-like CREB regulatory kinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Doublecortin-like and CAM kinase-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Doublecortin-like and CAM kinase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Doublecortin-like kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">JTE90_002849</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000416">
        <property type="protein sequence ID" value="KAG8183467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHB0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16109">
        <property type="entry name" value="DCX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17069">
        <property type="entry name" value="DCX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14095">
        <property type="entry name" value="STKc_DCKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000066">
        <property type="entry name" value="Serine/threonine-protein kinase DCLK1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.230:FF:000001">
        <property type="entry name" value="serine/threonine-protein kinase DCLK1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.230:FF:000002">
        <property type="entry name" value="serine/threonine-protein kinase DCLK2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Doublecortin" evidence="23">
        <location>
            <begin position="70"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="23">
        <location>
            <begin position="193"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="384"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="15"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00080759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAG8183467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="691" mass="78681" checksum="521E957FBD3A6D24" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIT7</accession>
    <name>A0AAV6UIT7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JTE90_028048</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="13"/>
    <dbReference type="EMBL" id="JAFNEN010000410">
        <property type="protein sequence ID" value="KAG8183684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIT7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="15">
        <location>
            <begin position="101"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG8183684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="678" mass="75323" checksum="48DAE64F32008B77" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJ31</accession>
    <name>A0AAV6UJ31_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000384">
        <property type="protein sequence ID" value="KAG8184206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJ31"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8010" checksum="5681FE52AE44E6F3" modified="2024-11-27" version="1">MSSSMLHSLTQLGRDNLSPGGAVEQAAAPPSSSADRRISRGGDALGRLNSLMMVFVALAMTLRRQAWRDGYFGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJ99</accession>
    <name>A0AAV6UJ99_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_005307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000401">
        <property type="protein sequence ID" value="KAG8183843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJ99"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8183843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="597" mass="69311" checksum="CBFCE9E743D19318" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKD0</accession>
    <name>A0AAV6UKD0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline/ethanolamine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_017760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000354">
        <property type="protein sequence ID" value="KAG8184905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKD0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8184905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="56788" checksum="4E7C773C28A0639C" modified="2024-11-27" version="1">MSNKVDNGKVGEDVKEQAYRICQEFLGSPWQDITKSKFEISVISGGNSNAVYRCSLSEDVAVEDPKTPSSVLFRIYGCFQEDKNVVVSEAATFMLLAERGLGPKLYGIFPTGRLEEYIPSRNLNSVDFRSMSTAIAREMAKIHALEVPVRKVGDFWHKHMKNGGNSNAVYRCSLSEDVAVEDPKTPSSVLFRIYGCFQEDKNVVVSEAATFMLLAERGLGPKLYGIFPTGRLEEYIPSRNLNSADFRSLSTAIAREMAKIHALEVPVRKVGDFWHKHMKNWLNYVEINKALRPKESFECIDMYKEEIDWLSEEIKKFNSPVVYCHNDLQGGNILLRQNPSSEDAPRIILIDFEYGAYNYRGFDLANQFCEWCFEYETENFPYFTWEFEKFPSVEEQTVFIRAYLNQQVEEGIIERSAIVPEVDKILEEVQFFSLACNIMWSLWSVQMSFKVNEDFALLHMEHTKLRTKAYWQFKEKYLNSRAINGNAESSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULH0</accession>
    <name>A0AAV6ULH0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CLIP1 zinc knuckle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_017048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000349">
        <property type="protein sequence ID" value="KAG8185024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULH0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLIP1 zinc knuckle" evidence="8">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="CLIP1 zinc knuckle" evidence="8">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8185024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="382" mass="44403" checksum="3F551D6027521003" modified="2024-11-27" version="1">MSSSEIHKEFTAKIADLEAKYTQVLEEKKKIAAEEQMSREAKKNLEETKDSLLQEKMKREEIVKDREAQLQALQEEVNRMQTNFTLHKQELQKKLDVSQLELEAAQELKRQLELQHSVLEELQQELHNSEEKCKSLEEQVKTMTVLTSDNSTMSKKLEEFEKREDEKNKKIASLTEEYEDLEESLKGYQSSLNSKKEECTSLNEKLKDLKRELESKDALQKSIKSLEQENILLKFEVDKLEKAKSEKNANQPAGATTNSSDAEERETLQSQVDFLNSIIVDMKQKNENLQLEVEALKMAPVEIDLNLNSVEKKLAPRLFCDICDVFDLHETDDCPKQESFIADEEVPHLLPQGARKMEERPYCNTCEIFGHWTYDCQAEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULT4</accession>
    <name>A0AAV6ULT4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ankyrin repeat domain-containing protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_022696</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000367">
        <property type="protein sequence ID" value="KAG8184648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULT4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="11" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8184648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39080" checksum="40CBA04232352977" modified="2024-11-27" version="1">MFSNFNFNEDIETWITYYYEMYQCHDSMPKVFFYETTFQGLAGTSYTFFNNDSTNAPSPQMLHRAVLKGDVKTLKRCIDANVPVDTRDNENTTALILACRYNQYECAKLLLEHGADPSAQRMTGTNSLCYAAQGGYYSLVQLLLKYGANIEDCGIDGGTPFLLACQCNHLSVAQALLDINAEFKQAMIDSSTPMYVAAQNGHSKIVSYLISQGADINIKRPDNTTPLFIACQNGHTALVKDLVNWGANLNVNRKDGCTPLFKASQKGYLNIVKFLLSNGAYSGLLKNGESPLHAAAYCGHIKVIKALVEAGANIFLKNKSGVTPLAKAFEGGHQIATRYLQRIQTEKSGGASTSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNT4</accession>
    <name>A0AAV6UNT4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPR158/179 extracellular domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_023886</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000341">
        <property type="protein sequence ID" value="KAG8185273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNT4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054714">
        <property type="entry name" value="GPR158_179_extracellular"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF25">
        <property type="entry name" value="MIP05539P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22572">
        <property type="entry name" value="GPR158_179_EC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043496196" description="GPR158/179 extracellular domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="770"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="GPR158/179 extracellular" evidence="11">
        <location>
            <begin position="258"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="GPR158/179 extracellular" evidence="11">
        <location>
            <begin position="636"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8185273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="797" mass="92436" checksum="348AC223C2E3173A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNU5</accession>
    <name>A0AAV6UNU5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription termination factor 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_022710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000311">
        <property type="protein sequence ID" value="KAG8186120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNU5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006393">
        <property type="term" value="P:termination of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15437:SF7">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15437">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8186120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="48131" checksum="58D0D8D6B9818B10" modified="2024-11-27" version="1">MELGFRDVSGRDIFQYQTLLKKSPKDLRKESYNICYNNNLEHFAQFSQEYEFTKTNEVTLKLKKLYEVDSNLQLIKESMNTEYISYKFNCSLFRVQQLFRMYPPLKCQSILITARLLDVLHKDYQMPDSKIFQSPSILSLHNESARSLLQNMPFILGVKTLEIVKKFPLMLRQSSDRVKQVENILKSYNITDEHLLCCPRILAFSPSTVKKRLHYLCNSESFLSMKSQKKFLWLVYHNKNVIPRLDALKAIDRPFSISVFMMTNTNFEKFLKFGSCRQTHNKDTFQYLANVLNLKENEVVLKLQEFPGSQNATIKNCIQVIEYLFRAGVTKKQIFNGLGVIVYDFEVVKFYFEDLPTRSAYQPFSDWTSHYNLIQLLIYAIEVDSGYKGSKVYGPRMKSEYAEKFAACLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UP96</accession>
    <name>A0AAV6UP96_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_022369</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000335">
        <property type="protein sequence ID" value="KAG8185438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UP96"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF76">
        <property type="entry name" value="NEUROPEPTIDE SIFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043518329" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="11">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8185438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="284" mass="31912" checksum="B5D28556918E4A1E" modified="2024-11-27" version="1">MEYIFFAAWILGLISCKAVAYLQGVSVCASVTTLVAISVDRFLAICYPMTLQITTRGCRIIIAAIWIFSLSLSLPWTVYFQLVSIGKSSYGDPLYVCREVWPTEQMGTVYFLVANLVICYLLPLLVFLVCYGSIWYRLCSRVLPGEGAHNNLLAKRSKIKVIKMLFLVVTVFMISWLPLYAVFIRVKVGGNIVDNSFEEYVIQVTAPVAQWFGASNSCVNPLLYAFFNEKLRTGFRNMLFGDGIGRDNERVLRLSIRNNMTFGNSSKKTTTSSDRKKSPNACAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URH7</accession>
    <name>A0AAV6URH7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_007334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000306">
        <property type="protein sequence ID" value="KAG8186313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URH7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043316547" description="Chitin-binding type-2 domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="4">
        <location>
            <begin position="352"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="829"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="710"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="829"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8186313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1115" mass="129019" checksum="634A4FB3B985058B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTI8</accession>
    <name>A0AAV6UTI8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4200 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_000182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000262">
        <property type="protein sequence ID" value="KAG8187717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTI8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025252">
        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF3">
        <property type="entry name" value="CILIA AND FLAGELLA ASSOCIATED PROTEIN 100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13863">
        <property type="entry name" value="DUF4200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4200" evidence="3">
        <location>
            <begin position="73"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8187717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="429" mass="49470" checksum="69DC45378A8AE9E1" modified="2024-11-27" version="1">MDRKRNISDEYSNARVDTCMVTMRSLRDLAEKEANLVQGALKDLENNLIDPGYILNLSKSIHGTGSKNVADYIKRNTDILLNEHATVVRQEVIQQMKKQIKDMNAEMSKDGKKLGEDISNFFEFIQKSYEIASASFKKVIEIAKKNYGKVELINETQDKLFSLKNELQDLEQQLVECLMCSEFLMTQIPEDYERKGVLLPKEFLASFGPTYSVEEKDKIQKEVLENVLQEGQNIEPVDVSLVSAEELMAVMNRLKNSNLSLVQNCHLNSGTSQFESTELETLQQQMNKELEVWDMKIKETEEELKKAKNKQIKLKTQIKDMEQMAAEKNKGQRENELKKLSEIYQICTGSEAKVTDIVLMRAAVDYSIEDLINEINIYPRKKIRELIKTLEAEKKQSERKAEGTLRSQRANERLKKTLNPIIKVKFPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU96</accession>
    <name>A0AAV6UU96_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000251">
        <property type="protein sequence ID" value="KAG8188002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU96"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="67" mass="7754" checksum="FD2933A337234F75" modified="2024-11-27" version="1">MDLAAKLLSSEGLSPGEIRALTQNDVKCTMTLMQEQDRLLMEMFDRREKEAKRQVTVEPQFFVAKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUL5</accession>
    <name>A0AAV6UUL5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000271">
        <property type="protein sequence ID" value="KAG8187487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUL5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="38"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="155" mass="17259" checksum="D5231B3FFA45B54B" modified="2024-11-27" version="1">MPKKLSCADCIQVARICVGDFVIEVAQTPYSSTDRQLPSFLHEPPNRHEFLNSSGAVIPCTAFGNPTPIVRWIHDDGTAASDIPGLRHARLDGSLVFQPFRADQYRQDVHATVYRCTASNVFGTLSSRDVNVVAGKTFTIFLQRIIYVDVNEFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUP2</accession>
    <name>A0AAV6UUP2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Histone deacetylase</fullName>
            <ecNumber evidence="17">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">JTE90_020669</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6)-(2E)-butenoyl-L-lysyl-[protein] + H2O = (2E)-2-butenoate + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:69172"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:35899"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:69173"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:58197"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58108"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:58109"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="17"/>
    <dbReference type="EMBL" id="JAFNEN010000276">
        <property type="protein sequence ID" value="KAG8187241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUP2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF14">
        <property type="entry name" value="HISTONE DEACETYLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="12 17" id="KW-0804">Transcription</keyword>
    <keyword evidence="11 17" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="21">
        <location>
            <begin position="56"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG8187241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="426" mass="48080" checksum="7F65B84099ACB702" modified="2024-11-27" version="1">MENLSNDIQNRFCVNTDATSSNSQGQFSRLSVAYIHSLDFELHLNKHPRLLGTVSVTDNLIRAYQLLDYVTVIPPQLATFEELKTFHSEEYIEFLKKVNDLTEDDLLEEEEEEMEKYGIGYDCPFIPQIYDAASMIGGATVTAAKALLSGEFQVAVNWGGGWHHAKKDQADGFCYVNDIVLGILQLLQKYKRVLYVDIDLHHGDGVEEAFSHTSRVLCFSVHKNDVGFYPGTGLLHDIGHGKGKYYTINVPLFDGIQDSQYLELIIPLLSKAQKRFQPDVVVCQCGADTLAGDPFAAFNLTLKSPGECIKLIKSWNIPLLALVEVHKIGLWMNTISICGKNYNFSGGYNAVNTARCWTYLLSLLLDKTLEQDIPDHKFLMKYGPDYELQIFPKTMPNRNSVKHLKLITDTVLKNIDFIQPPSQEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUX1</accession>
    <name>A0AAV6UUX1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Fibroblast growth factor receptor</fullName>
            <ecNumber evidence="19">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">JTE90_011686</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Receptor for basic fibroblast growth factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="19"/>
    <dbReference type="EMBL" id="JAFNEN010000274">
        <property type="protein sequence ID" value="KAG8187316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUX1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005007">
        <property type="term" value="F:fibroblast growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000007">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000016">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000020">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000593">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016248">
        <property type="entry name" value="FGF_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF550">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000628">
        <property type="entry name" value="FGFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 19 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 25" id="KW-0732">Signal</keyword>
    <keyword evidence="3 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12 19" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043675371" description="Fibroblast growth factor receptor" evidence="25">
        <location>
            <begin position="23"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="42"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="163"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="262"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="353"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="571"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="711"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="577"/>
            <end position="583"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="653"/>
            <end position="655"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="715"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="729"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="186"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="281"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="375"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00056965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR000628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000628-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000628-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000628-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAG8187316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="872" mass="97695" checksum="55BF8FB9DB38F3A2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWY2</accession>
    <name>A0AAV6UWY2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000225">
        <property type="protein sequence ID" value="KAG8188962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWY2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="80" mass="9762" checksum="4612C1558C09AED6" modified="2024-11-27" version="1" fragment="single">CFSRELFDAARTRLIPYINKFGSAWPFRRIQWTESCIPIFTCSAAITPTTLSVFHYNYRCKHHHCILKPWDRRPWDHFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXA5</accession>
    <name>A0AAV6UXA5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein phosphatase PP2A regulatory subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_008000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000238">
        <property type="protein sequence ID" value="KAG8188433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXA5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000011">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="5">
        <location>
            <begin position="278"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="285"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="328"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="523"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8188433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="597" mass="66562" checksum="236DEDF6F220CE12" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXL0</accession>
    <name>A0AAV6UXL0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000237">
        <property type="protein sequence ID" value="KAG8188533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXL0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12581" checksum="CFA83716CF5B36BE" modified="2024-11-27" version="1">MHIPPPPHDKDVAEFQTCRLQKPLKIDGTALERRYNTQSADSKGLRQREWLLFIDEDPFLMIFINRIDADASFSTSTQLTRHRLLGITTTLKVPTLRGVRPREWLYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYD4</accession>
    <name>A0AAV6UYD4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peripheral plasma membrane protein CASK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">JTE90_021856</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAGUK family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000217">
        <property type="protein sequence ID" value="KAG8189351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYD4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019098">
        <property type="term" value="P:reproductive behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10831">
        <property type="entry name" value="PDZ_CASK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12035">
        <property type="entry name" value="SH3_MPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000146">
        <property type="entry name" value="MAGUK p55 subfamily member 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000051">
        <property type="entry name" value="Peripheral plasma membrane protein CASK isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000062">
        <property type="entry name" value="peripheral plasma membrane protein CASK isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000016">
        <property type="entry name" value="peripheral plasma membrane protein CASK isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 16" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="10"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="L27" evidence="21">
        <location>
            <begin position="338"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="L27" evidence="21">
        <location>
            <begin position="400"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="20">
        <location>
            <begin position="487"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="574"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="19">
        <location>
            <begin position="699"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG8189351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="886" mass="100175" checksum="1040BA8308FF945A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYP3</accession>
    <name>A0AAV6UYP3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000232">
        <property type="protein sequence ID" value="KAG8188728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYP3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="119" mass="13899" checksum="6E5C6BB1017E2ED9" modified="2024-11-27" version="1">MDFVPKDHLSVSRCLFHGCFLCYDANVVNPISRIKMGVLFRQTAEMTEKPRTAGYQVLEKWEHEFQKDKKSDPQLKPFLESHELQDRLNPRDAFFGGRSNAIQLFYEGNAKYSFIDFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYT3</accession>
    <name>A0AAV6UYT3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SEC14-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_021882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000217">
        <property type="protein sequence ID" value="KAG8189379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYT3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="73"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="2">
        <location>
            <begin position="279"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8189379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="56338" checksum="77588BB3BC1B786E" modified="2024-11-27" version="1">MTGDEITNEEQESIDKFRARVQEILLPIHHDDFYLRKWLIARKFDLDKAEAMLRKHMKFMRVNGLDKIDENYTPLEATDYFHMKMLGYDCEGSVVRIIHIGASDVQGLVLSTTKMDCFRAATHYLMCDSRTQKRERANDIICHKQVYIFDLNGLSWRAVLQRTVAERAFSLLKNYEDNHPESLKAVYVINAPSFFSFIYNWLKTVLPESILLKVHILTQENCREALTEKIDPSILPVSVGGDMIDGTGDPNCPTLYKKPLDATVPETLYLYNQERVLDKDPLAKRTEVDIGCAFRLETEITQPNSVLQWDFHTNNYDISLALNYKKDHSSEFSVLMPPHRVESHKFPESGNLTCHETGIYELVFDNAYSWFTRKDLVYKIRVVTPDEIKRKQDENRHKRNCVVRDSCCNLVRSSAASPFRGSICLLHCPLRLHLCSSRDVASVPFRSECGPIPRTPHQRVPSSHDLPPARVTILPASWTSTVKVFLQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZB3</accession>
    <name>A0AAV6UZB3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_028636</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000221">
        <property type="protein sequence ID" value="KAG8189092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZB3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000003">
        <property type="entry name" value="E1A binding protein p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808">
        <property type="entry name" value="CBP/P300-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808:SF1">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00551">
        <property type="entry name" value="ZnF_TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57933">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50134">
        <property type="entry name" value="ZF_TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="17">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="TAZ-type" evidence="16">
        <location>
            <begin position="63"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="TAZ-type" evidence="16">
        <location>
            <begin position="185"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TAZ-type" evidence="13">
        <location>
            <begin position="63"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TAZ-type" evidence="13">
        <location>
            <begin position="185"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="283"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8189092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="337" mass="37430" checksum="7A8A34D165DBA7AA" modified="2024-11-27" version="1">MAKTQSRQDQFVYICHNCNYNVETRWHCTVCDDFDLCVKCYTKDGHVHKMQKLGFELGNDSTVGEKKQINPKCIKLTLTLEHACQCSDANCGLLSCRKMKRMVSHAKKCKRRDSCAICKYLVALNCLHSKNCQKNTCPVLFCLSLKNKLKQRRMTQQQIPKPQSQLMGANNMPNPAGAASGPGVGPSQVMAKPECQVSDSCIKLTLTLEHACQCSDANCGLLSCRKMKRIVLHAKKCKRRDSCAICKYLVALNCLHSKNCQKITCPVLFCLSLKNKMKQRRMTQQQIPKPQSQMIGANNMPNPAGAAPGPGVGPSQVMAKPKRQVPDSCSRGAFNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V080</accession>
    <name>A0AAV6V080_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain containing 28A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_011909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000191">
        <property type="protein sequence ID" value="KAG8190185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V080"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025271">
        <property type="entry name" value="CCDC28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13400">
        <property type="entry name" value="CHEMOKINE C-C MOTIF RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13400:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 28A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13270">
        <property type="entry name" value="CCDC28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8190185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29688" checksum="3299995D0EC79FDA" modified="2024-11-27" version="1">MESSTKEEPIEPTIIPVVMQSPTNENLNTVLEISKDEDSENQELQSEEPVPKVSNEARHSVGSYIVPHRERISRISGSLGVGGGRSHRPSQSEKPLAKSQSEIQVNTTNSLSVSQNSKNSLMTYSSSGTFYDHSRKKMDVRLPPKPVQSSSGKDTTDFRQMEQGLLQLLEDFHCGKLEGFGSNCTFEKMENVREQQEKLARLHFDLNAQQEMCGYVKNVQHTDEGIQVAKGNLAQLIENLQQLSQSIEQLQSGSPTTENEKQLRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V116</accession>
    <name>A0AAV6V116_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000207">
        <property type="protein sequence ID" value="KAG8189692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V116"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9423" checksum="ACB64419A72D0B71" modified="2024-11-27" version="1">MAARAVNSERRGEDSGSIEGLIRGDAGGSDHGGGMRSGWMERVVLERGIHGVMNKLVKMSRDDTEMQLGLKRRSLGICGVRHRCDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V1M5</accession>
    <name>A0AAV6V1M5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000182">
        <property type="protein sequence ID" value="KAG8190515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V1M5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8190515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="240" mass="26964" checksum="C879CDF7DCE5743C" modified="2024-11-27" version="1">MACYCISHKEDVRSETDEPSSSMELDAALHELGMLSKITDSRTDFIQEKMLKQKKKVRYSNSLSSAPLCVVQMNSKFITKFSLSSKNFQSDSEDEKTDGPTVSDDLLVTPNFWIEPSTAKQSRLKAMSPRQRRKLARCQPYDPCYRNHRASHHVIPDVEDCASSPAVVSRQDSGGNKSNPSSPAKSQNSHPKTPSLVRSRSLDDLEIAKVDESPKEDCYCRYGRLDIETVSQRISKLNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V3T2</accession>
    <name>A0AAV6V3T2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium-activated chloride channel N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_008376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000167">
        <property type="protein sequence ID" value="KAG8191062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V3T2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013642">
        <property type="entry name" value="CLCA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08434">
        <property type="entry name" value="CLCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043697813" description="Calcium-activated chloride channel N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="910"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium-activated chloride channel N-terminal" evidence="3">
        <location>
            <begin position="28"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8191062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1150" mass="129579" checksum="4DA4BD989839E710" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V427</accession>
    <name>A0AAV6V427_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Agenet-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_024878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000175">
        <property type="protein sequence ID" value="KAG8190748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V427"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048170">
        <property type="term" value="P:positive regulation of long-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099577">
        <property type="term" value="P:regulation of translation at presynapse, modulating synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22425">
        <property type="entry name" value="KH_I_FMR1_FXR_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22426">
        <property type="entry name" value="KH_I_FMR1_FXR_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20402">
        <property type="entry name" value="Tudor_Agenet_FMRP-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008395">
        <property type="entry name" value="Agenet-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040148">
        <property type="entry name" value="FMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040472">
        <property type="entry name" value="FMRP_KH0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041560">
        <property type="entry name" value="Tudor_FRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603">
        <property type="entry name" value="FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603:SF7">
        <property type="entry name" value="FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05641">
        <property type="entry name" value="Agenet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17904">
        <property type="entry name" value="KH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18336">
        <property type="entry name" value="Tudor_FRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51641">
        <property type="entry name" value="AGENET_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Agenet-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Agenet-like" evidence="3">
        <location>
            <begin position="66"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="582"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8190748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="694" mass="80208" checksum="A155CB73D00C7936" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V452</accession>
    <name>A0AAV6V452_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CHHC U11-48K-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_028316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000173">
        <property type="protein sequence ID" value="KAG8190817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V452"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8190817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="181" mass="21523" checksum="0697BB5803406F64" modified="2024-11-27" version="1">MDVDSNKKEDRPYFPPAKKSSLAGSVEMRKIPIPPNRYAPLKENWMKIFTTVVEHLHLHIRFNLKAKLVEIRMGDKIVTCPYDICHKVKETRLKIHISKVHAKEKYLNKNLYECFYNPRHVVPLSQRLEHLMGCKDNVDRFKFELVEPDPSKNIYENEIKTYMRTPKSEMRAELNKTLDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V548</accession>
    <name>A0AAV6V548_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000168">
        <property type="protein sequence ID" value="KAG8191053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V548"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8191053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="126" mass="14528" checksum="F50B8483DD1F2511" modified="2024-11-27" version="1">MGRRWPLDASSEMITKLRKIQLCISLQYRSKLPLYESPKRLQRVEKSVVHQISESGFQKRVNTSTYPPRQMWVRCRTQALKTASKGPCRQSFYDHGQTSAFTTTSSVARPPLEIGVSRERPMTIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6U7</accession>
    <name>A0AAV6V6U7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SREBP regulating gene protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_022806</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SPRING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000151">
        <property type="protein sequence ID" value="KAG8191813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6U7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000640">
        <property type="term" value="P:positive regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019352">
        <property type="entry name" value="SPRING1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13481">
        <property type="entry name" value="SREBP REGULATING GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13481:SF0">
        <property type="entry name" value="SREBP REGULATING GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10218">
        <property type="entry name" value="SPRING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8191813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="206" mass="23378" checksum="FF96B9947175C529" modified="2024-11-27" version="1">MLSNRIFRFLKRKVVLAVLFTLSFFYCLLHWLPENEEAMSDDNMIPPLNLPSQSFKWHTSWEKTNHSNSKLSSCRNSVQGKVLIADDKGFVCSRHDVLSNGCCNMDSPTTSRYSCDSCHDNSCCSIYEYCISCCLQPEKRQLLMKILGKASETFNILFASITDHFELCLTKCRTSSQSVQHENSYTDPKSKHCYGESPPAAQLGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8D0</accession>
    <name>A0AAV6V8D0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ran-GTPase activating protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_028092</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000132">
        <property type="protein sequence ID" value="KAG8192970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8D0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.200">
        <property type="entry name" value="Ran-GTPase activating protein 1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009109">
        <property type="entry name" value="Ran_GTPase_activating_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036720">
        <property type="entry name" value="RanGAP1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07834">
        <property type="entry name" value="RanGAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69099">
        <property type="entry name" value="Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ran-GTPase activating protein 1 C-terminal" evidence="5">
        <location>
            <begin position="411"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8192970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="583" mass="64191" checksum="52DA30EFE86C1363" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8Q9</accession>
    <name>A0AAV6V8Q9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_015206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000138">
        <property type="protein sequence ID" value="KAG8192572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8Q9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8192572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="87" mass="9876" checksum="9351366AD10E9B41" modified="2024-11-27" version="1">MLRLGDPPGAGWHQRSGLTGMLRLGDPRWSWLASEMARDFGGHYASAEGFLWHLGVLRNSRQPDHVMENFSDFTRWASYGSDPIMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8R1</accession>
    <name>A0AAV6V8R1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Signal transducing adapter molecule 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_028129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000132">
        <property type="protein sequence ID" value="KAG8193009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8R1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03568">
        <property type="entry name" value="VHS_STAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="VHS" evidence="8">
        <location>
            <begin position="17"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="205"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="614"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8193009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="72976" checksum="869CC8C68ACF1175" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAZ3</accession>
    <name>A0AAV6VAZ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000114">
        <property type="protein sequence ID" value="KAG8193799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VAZ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8193799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="71" mass="7847" checksum="E7A01C9ABC7B3657" modified="2024-11-27" version="1">MKSSPYCVEACENFKLMSLPEPSHCGQSRPLEYPAASASAGLASEWGRNPISTLHSWWCDTQEVEEASEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VB92</accession>
    <name>A0AAV6VB92_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NtA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_005567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000127">
        <property type="protein sequence ID" value="KAG8193220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VB92"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004850">
        <property type="entry name" value="NtA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03146">
        <property type="entry name" value="NtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51121">
        <property type="entry name" value="NTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043484867" description="NtA domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="NtA" evidence="3">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8193220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="132" mass="14942" checksum="AF1CA82F651A60A9" modified="2024-11-27" version="1">MKTIYIFCIVLLSSTFVSSRRRRSEQCRDKLDPSASMVFTGTVERLYRSRSETYRGVVKVKRVVKGDSNFADNTVIVEGFGDPNICNSDVRERDTRIFLVRQLDSGHLRLNSSVVRVTVSNLDKVVSSSMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDT5</accession>
    <name>A0AAV6VDT5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_029552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000114">
        <property type="protein sequence ID" value="KAG8193818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VDT5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042237">
        <property type="entry name" value="PTRHD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8193818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="146" mass="16587" checksum="A9928415E084948D" modified="2024-11-27" version="1">MAGPTAASMQLVQYVIVRGDLLKTCKWPVGALIAQACHATSAVLHLYYDDIHTQVYLKDLDRMHKVILEAPDESSLWKLSNELETNDIFHKIWIEQPENFPTCIALEFSVSMFFSWQGFRAQSYSMLATGTFVLDFTSFESQISEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VEZ5</accession>
    <name>A0AAV6VEZ5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Enoyl-CoA delta isomerase 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">3,2-trans-enoyl-CoA isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JTE90_001392</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:29847"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
            <dbReference type="ChEBI" id="CHEBI:61968"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:29849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3Z)-decenoyl-CoA = (2E)-decenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:77195"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:195601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:23716"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:58543"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:46044"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:85640"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:46045"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000089">
        <property type="protein sequence ID" value="KAG8195375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VEZ5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000034">
        <property type="entry name" value="Enoyl-CoA delta isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF45">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG8195375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="288" mass="32506" checksum="823DBD26EB1FB858" modified="2024-11-27" version="1">MFNKIKPFAKILRPNNFKVISLAQASNGGSKSLVNVIEDEKKKVATVVMQRPPVNSLNFELLESITQAVKGLEEKNFRGMILSSSSPTVFSAGLDITEMYNPKEERLVKFWKALQTMWKTLYLTPLVTIAAVNGHAPAGGCLLTLTCDHSIMVKSRASIGLNETMLGIVAPKWFRDMYINAIGFRRADHALKLGKMFTPEEAVKLNLVNELVDSPSELMEKVENEMGKWLKVPAVALQMTKLSMRKPHVEELISYENQELEEIVHFVFLEETQKMLGKYFESLKAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VF50</accession>
    <name>A0AAV6VF50_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclic nucleotide phosphodiesterase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_024576</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000106">
        <property type="protein sequence ID" value="KAG8194246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VF50"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009214">
        <property type="term" value="P:cyclic nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1740.10">
        <property type="entry name" value="2',3'-cyclic nucleotide 3'-phosphodiesterase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008431">
        <property type="entry name" value="CNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047325">
        <property type="entry name" value="CNPase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10156">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10156:SF0">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05881">
        <property type="entry name" value="CNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Cyclic nucleotide phosphodiesterase catalytic" evidence="9">
        <location>
            <begin position="190"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8194246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="481" mass="55412" checksum="6E94D0468A338281" modified="2024-11-27" version="1">MASYCSDSDEEESIVSEVSNLALGDDKNSKPEHYFPLQMVTDKKTEMYVKFAKVMVIIQGPYTHLRSLASPDVSKAFPYASRVLSDDTYRKDRKTICKYEETEEFYEYFKRESRRALENCDNLLLLDSTMSNKQQNSYYCAIALRMKYVVLVVPPIVTGLHKENWPSRSQAASFRKSDTFIQAATQFQHLFCGWYLHDVDCDELRHIATLYLQDCIEDIPDFKDMFSKVNVPGGKVTKDMDDREFASAIASRYFKLDEKRQDLAYCVTKHFNNQLFSMNEYFKNEHVQKNYGKMSKLIISGFVVSPHMIAARVKLNFHQKNLWDMPDELDENGKFPLCCVSELVDKMKDELPQVDINLVSSKNNPTIVNSHTCHDPTQNILPHVKGRACHIVLGKAPGAPARNVDYDVQFALRRLRNSMKPEAQGSVANIPLSRCVVRRLGKYWLIDLNEMLSVDGFFASCIKPYPYENAMEGSNSRTWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGA4</accession>
    <name>A0AAV6VGA4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000094">
        <property type="protein sequence ID" value="KAG8195073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGA4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8195073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8648" checksum="FA8176FDE0B1FE7C" modified="2024-11-27" version="1">MALYHELGLISPRVHSNALEVRSLGIVWHSPKAKASPGRKTRASPEQRISSSECKFRCRRDKNSLEMKCLVEERAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VIB2</accession>
    <name>A0AAV6VIB2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_001375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000089">
        <property type="protein sequence ID" value="KAG8195356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VIB2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8566" checksum="D07F1F7C59C1A0F6" modified="2024-11-27" version="1">MKYYDPVFLLMMLMSAIILNCPTTTAGFLRRRQESQHKEIMAAGLVAKMLQENDHRVVHVHHIPVFIPVFHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJD6</accession>
    <name>A0AAV6VJD6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_028992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000075">
        <property type="protein sequence ID" value="KAG8196022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJD6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BESS" evidence="2">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8196022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="86" mass="9861" checksum="134E9956CF17DCAC" modified="2024-11-27" version="1">MHKSPLPKKIKVTLAQERLDLLKEMVMRKVAAPSDPDDSVEFFYRSVAATVKQFPIMDQMRMQCKVSELLADMVEKKRAVVQAKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMZ6</accession>
    <name>A0AAV6VMZ6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 4 helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_001893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000045">
        <property type="protein sequence ID" value="KAG8198060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMZ6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056549">
        <property type="entry name" value="HTH_NOL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039788">
        <property type="entry name" value="NOL4/NOL4L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449:SF22">
        <property type="entry name" value="NUCLEOLAR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23079">
        <property type="entry name" value="HTH_NOL4_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein 4 helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8198060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="528" mass="59017" checksum="941B02C847A73416" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VN02</accession>
    <name>A0AAV6VN02_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spondin-like TSP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_024259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000048">
        <property type="protein sequence ID" value="KAG8197860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000019">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF30">
        <property type="entry name" value="SPONDIN-LIKE TSP1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043361282" description="Spondin-like TSP1 domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1472"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="6">
        <location>
            <begin position="695"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="6">
        <location>
            <begin position="934"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8197860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1541" mass="172179" checksum="24B3C073F6E84D83" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VN46</accession>
    <name>A0AAV6VN46_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000058">
        <property type="protein sequence ID" value="KAG8197161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VN46"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF73">
        <property type="entry name" value="FI21235P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8197161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="635" mass="73326" checksum="952ECF5BC15E42CE" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPQ4</accession>
    <name>A0AAV6VPQ4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_026526</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Presynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000038">
        <property type="protein sequence ID" value="KAG8198629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPQ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18367">
        <property type="entry name" value="BTB_POZ_KCTD8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22204">
        <property type="entry name" value="H1_KCTD12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057093">
        <property type="entry name" value="H1_KCTD8_12_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23110">
        <property type="entry name" value="H1_KCTD8_12_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="BTB" evidence="10">
        <location>
            <begin position="43"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8198629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="268" mass="29985" checksum="A2BC8A479C671A14" modified="2024-11-27" version="1">MRVVPVEGGLRIDFLEPSGSQSIPPHPPMATMASETEDSGFPAVIELNVGGVFYTTSRATLTKVPTSLLGQWFGGPLSTGPFRDSKGKFFVDRDGVLFRYILDFLRDQRVVLPENFHERRRLRHEAEYFNLPGLIAKLDSPGPPGYIIIGYRGTFAFGRDGLADVKFRKLTRILVSGRVNLCREVFGETLNESRDPDRGSDCRYSARFFLKHNFLEQAFDMLQEAGFRCVAAAGSGTSCGGAGEPMKPGMDSEENRWNHYNEFIFTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRE1</accession>
    <name>A0AAV6VRE1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_000305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRE1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="79" mass="9349" checksum="69503999320A62DB" modified="2024-11-27" version="1">MNDPPFRAIKRPLCAHLTSSTKSPTFIAKNRPLRAVHRHLNYNSVGNFRVELPEKPLLFRTIDLSWRRRNKMARLRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRX8</accession>
    <name>A0AAV6VRX8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_000321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRX8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000178">
        <property type="entry name" value="Saccharopine dehydrogenase-like oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8199454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="430" mass="48303" checksum="586078C48F392A84" modified="2024-11-27" version="1">MASRDFDIIIFGGTGYTGQYVIEELANSSKQTGIKWAIAGRNIQKLKEALNTVQKYIGNSSDISGTTVIQADVKDEASILDMCKQGKLVLNCVGPYNLYGEIVVRACIEAGTHLVDISAEIKYSETMQAKYFMQAREKGVYIVEACGFGSVPADYGISLLKNEFAGDLNAVEYYFEIGVGSEGRKTNYGTYTSIIHSIKDQLFSVGKYKEALKKEVFKKDLAKSCFPLHKRCILSYNNEVNGWCLWYLGPDERVIHRSQQFRYEYLNERTVQCNGYFQLPSFFISLGYLFFAAVVALMSFFSCGLHILKKYPSFFTAGEISLTGPTRKQVMEGTTKFTLYGTGWSNKLEEPTDQHTTQPDKKMKLTINGPEAGYVLTSMCMVQCGLTMLEEQNKLPLEGGVLTPGVTFQNTSLRQRLEKRGMIFEFETIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VRZ2</accession>
    <name>A0AAV6VRZ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_000278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000027">
        <property type="protein sequence ID" value="KAG8199410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VRZ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8268" checksum="D613930EDFF4AECB" modified="2024-11-27" version="1">MLSRRQSTTQQITVTPPSHDHHRIRKKCLAGLPAKRGKPGTSGATSECEQPTGLHGYSACALFGYSFKTTARHFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS51</accession>
    <name>A0AAV6VS51_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000037">
        <property type="protein sequence ID" value="KAG8198662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VS51"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7646" checksum="98799846C8BB5CA0" modified="2024-11-27" version="1">MGQGTITNNHIGNIHQSIILSGDQNKKIIAHIANTFEDPDVTTSREPQSRERLSLGHRTKGLGGRPDTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSD6</accession>
    <name>A0AAV6VSD6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSD6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="128" mass="14600" checksum="6D84A5319FD4C9C0" modified="2024-11-27" version="1">MDKLLSQLEKSIPNNEAKCEIPDFHLHSKLNLKNSDLARWWQSCCISSQLAPIKPNSGFGHSSKIRDFVHGSFSRYRPSPSATDSVSLSLPTIPKLNFKKCVLVLFFKKNTVFIFDILRMETFPNNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSG3</accession>
    <name>A0AAV6VSG3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSG3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="227" mass="26380" checksum="67FFADF39103F289" modified="2024-11-27" version="1">MAVKNRMLLNFQLDIFTNLLVLFLKFLFCSSPKEICLSLKIDYPLVDKFQSKFIFKFQTRIINKYTCAQFLPQNSCFLSWKNSSQESQEKRSRSSEIDLGGGGKGRGGSKKSETREERKVPQTVSRMPERRTGLYNSRPTFAAFSKPNENFYSFSRREDSERSCVACGLREKSFACRRKCVLLILSVCSDGSVKKEEEKIPVTKRNFICERKILTNMEECWRGRCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VSP0</accession>
    <name>A0AAV6VSP0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000035">
        <property type="protein sequence ID" value="KAG8198766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VSP0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="128" mass="14563" checksum="73465A2E2513DBB3" modified="2024-11-27" version="1" fragment="single">NQNVTFPYSTHSPLQSDRSAICLREVDDPEKTRSPEKCPFDSSGGGSKHFSNISLRRRCLRFVPDRSTSCYKFKRAWHNFPTSVGSEEAFRPIEVQSFASLCKDGSKHSIPQFFGIVSFHAKRESVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VTC3</accession>
    <name>A0AAV6VTC3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SCAI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000036">
        <property type="protein sequence ID" value="KAG8198746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VTC3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022709">
        <property type="entry name" value="SCAI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21243">
        <property type="entry name" value="PROTEIN SCAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12070">
        <property type="entry name" value="SCAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8198746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="67559" checksum="615CCDE21EDE62C4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VW43</accession>
    <name>A0AAV6VW43_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_006381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000013">
        <property type="protein sequence ID" value="KAG8200800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VW43"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="73" mass="8435" checksum="D389436D15ACD197" modified="2024-11-27" version="1">MYQRLDILHGDFVVLREDLKSSNFELLTSVAIPKGGHTRIFLPFWALTCQEYSLKIKLQITSSKIDLCQPRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VX04</accession>
    <name>A0AAV6VX04_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_001252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000021">
        <property type="protein sequence ID" value="KAG8200021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VX04"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="77" mass="8588" checksum="28B1118786F2B32D" modified="2024-11-27" version="1">MTELKSISLTSLFNADLTHILSLYRFSPSLAPSPITSAPFKSPAPPTKGAQRAMKLRRLHNEGRPPIFFPFPLHLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXX5</accession>
    <name>A0AAV6VXX5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000011">
        <property type="protein sequence ID" value="KAG8200918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXX5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="109" mass="12455" checksum="E6127133756276E7" modified="2024-11-27" version="1">MGKKKVGKIRTASTAAKQTLLQTSLFSAAVHIIVELVVPRFLLSPAKWINLSCTCEGWHFEVSDSSRELRSMLINQQELINCLQIQIRKRAFSSLPSLFRFPREPLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TDR0</accession>
    <name>A0AAV6TDR0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_026913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006908">
        <property type="protein sequence ID" value="KAG8155727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TDR0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8155727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="241" mass="25930" checksum="DD577522DF02041B" modified="2024-11-27" version="1">MPAPGPKKPTKSAPRSGSRVKREAGGDGPARKLHISLGFSRANRGAPGHRKRAVLFKENSVPISGRAHFPGHENLTKEKNNSSPGPPSTFRVRFRFPKLVPPKEPIPCPGWGILKPKFPFPPVGSEGKKRALCLRFGDVSLPGKGFSDPLGRMTPCSTAVPPWKTPFPASVLKALKFSICYTTKICTVAGPGGPTPPGPSTHAKNPDPPTHGRKPPRWKLAVAARYSPTLESHPFKGSAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKC8</accession>
    <name>A0AAV6TKC8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_010260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003069">
        <property type="protein sequence ID" value="KAG8172133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKC8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8172133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="326" mass="36458" checksum="4D2557022CA08E6D" modified="2024-11-27" version="1" fragment="single">ALFPAAKDLVLQLDCDRDSIWFAVSPVGWASWHIIITVTFCGVGVFLFEGLPYFLSPTYYWDLVDRYEITHLYLYSNALGRMEKLGYAPSDKNHLSTLKACFSATTIVKPKYYDFMYTKVKKDIAFAAAYGATEIIGLCISLELTTNVYRGELPALCLGNDVQCVNEKGEPVEGEYGNLVIAKSCPNFFLGIWGDSDRSIARKNYFSKFSGKFSLGDFGIVNPFTKGFLICGRSDTTLNQGGLRFGSSEIYNVLDSIPEVRDSVCVSKYSTEMDESAVLFLQLETGCFYNESLIQRIREAISTELSPFHIPDVIIETKQIPVSITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKL4</accession>
    <name>A0AAV6TKL4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_004603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002803">
        <property type="protein sequence ID" value="KAG8172352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKL4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="279" mass="31758" checksum="E56B608E6F6F5013" modified="2024-11-27" version="1">MVLCFLRNRFLSAKRLNLHVFVRNAHQLNLNKVDNSSELTKSLFQLCMSLDVVDKEFLEKFKELSSSGTENLELSKEHNEFIQILKSTKTKLHDIEDEILPDVQLIPNFVDDLTPHEKDVILLSEPVDQELSTVSHKVVGTNMGLLTFSETSPTAYFLLGELSELEHEINTYFAMRLMPFGFAPMACPDFCKSFISEAVGSDPHSQDNCIQLQPPKDNNKESGQKNIVVGSSSFETFCAYFTNMNVNESNLPLRYFSQGRSYDARHRNVSLPTYSRLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TN65</accession>
    <name>A0AAV6TN65_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001986">
        <property type="protein sequence ID" value="KAG8173198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TN65"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="142" mass="16983" checksum="21775257549FC34A" modified="2024-11-27" version="1" fragment="single">MQEELLYEVETYLTEVEDAGEKEISILKDNISSYMREVGLSWSNKIDKSFNEMDKQPSAMETFCERVEDITSADIRDTFILDQQEVSRLWKKAFDDLLMLSAELKRYRCSYYMSKSKLERAIYWMKRNYRDNMPKHSKTQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPQ1</accession>
    <name>A0AAV6TPQ1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001470">
        <property type="protein sequence ID" value="KAG8173830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPQ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8173830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="268" mass="30582" checksum="12FBDB59B0F459C7" modified="2024-11-27" version="1">MEYPNLIRCVLANPVLANSVQEMTNQSGMLNLVDPEWENRLNSYPVHESHRNRKVAFSKGRACSHEGAHVRNVSQPAFSYKVIVLASFTSDRLKSKDLDTPPGDMSFVVRDCPPLTTIGHAMAESNDYTLYDGARLFMNTCNPNLCIHCKTQHKKFNIPCDVYKNWCVTKICLFDGQTLNHTFKKVLEKELEKMGQFWAICQVHIYSRTTFGERKYKVGGIITNLIVFQEISIQPAMDMTLLEHGQVPSIEFPTRDDEDSEAIINYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRF2</accession>
    <name>A0AAV6TRF2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TTF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001262">
        <property type="protein sequence ID" value="KAG8174284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRF2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006580">
        <property type="entry name" value="Znf_TTF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00597">
        <property type="entry name" value="ZnF_TTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTF-type" evidence="1">
        <location>
            <begin position="40"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8174284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="338" mass="38521" checksum="416EFBCE13BC9A9F" modified="2024-11-27" version="1">MDISLYKNKSLSGTEKLHVLENLWAPSSNYKFPATTHGKQERKFLYSWLQKYKWLSYSEIENRAYCTYCILFAPTEVDMRSSQKTGQLVQEGFQNWKKAIEKFESHSHLQYHKHAMIDLNSLKTVVEGKMNPIDRSLDVGKANQAKENAERLKPIIETVIFCGRQGIALRCHREYGDFNLDAMPDDNEGNFRALLRMRIEAGDEKLGDHFKSCGKNATYISWNIQNQIIDACDKVIKSHIVKDVKDTFYSVFADETTDVSTQKQFSLSVRYVSHNPKDGYKINEKFLQFVPLASTTGQVLGETLLKGLEECNLEIKDLRGQGYDGASAMSGKVKGVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TRU5</accession>
    <name>A0AAV6TRU5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001250">
        <property type="protein sequence ID" value="KAG8174341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TRU5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8174341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7789" checksum="46483243735B0C59" modified="2024-11-27" version="1">MYAFNSSRCPGPIWTRLKPSENRLINKFDFDSIMLYGERTFSKDGWGRSMKAKKKGIKIKDVMAKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUB8</accession>
    <name>A0AAV6TUB8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase</fullName>
            <ecNumber evidence="7">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_022614</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="7"/>
    <dbReference type="EMBL" id="JAFNEN010001048">
        <property type="protein sequence ID" value="KAG8175191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUB8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="10">
        <location>
            <begin position="177"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="9">
        <location>
            <begin position="473"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="942"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="942"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="954"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8175191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="964" mass="112932" checksum="D20D50D092262CC2" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TVI6</accession>
    <name>A0AAV6TVI6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transforming acidic coiled-coil-containing protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_012204</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001008">
        <property type="protein sequence ID" value="KAG8175412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TVI6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1700:FF:000001">
        <property type="entry name" value="Transforming acidic coiled-coil-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF10">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL PROTEIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="9">
        <location>
            <begin position="350"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="352"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8175412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="542" mass="61145" checksum="709E81639B83CF48" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWL1</accession>
    <name>A0AAV6TWL1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000918">
        <property type="protein sequence ID" value="KAG8176076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWL1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="198" mass="21995" checksum="F13B17578625865A" modified="2024-11-27" version="1">MPSAGFKIPDIIEESSGREEPKKESTYSTTRPLMRARQNASVNAIKKSKSASPAKTQVTASAATGYDESYNLAGPSNPKQDDNQFKRAYMDYYGYQGSYTDVPQKTVKSDKKAQVNTSSKGKKRQRTFDADESTIPVKSFKRYAPEAVAKSLGDVNFENSSDGSKVPIALRCLGFKRIPDIIEESSGPRRSRRLKNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWM7</accession>
    <name>A0AAV6TWM7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_021096</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000920">
        <property type="protein sequence ID" value="KAG8176043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWM7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="681"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="742"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="816"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="862"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="916"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="782"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="792"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8176043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="947" mass="108329" checksum="CAA16A8242C8D8FD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TXK2</accession>
    <name>A0AAV6TXK2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000918">
        <property type="protein sequence ID" value="KAG8176071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TXK2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8176071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="242" mass="28007" checksum="94E57031BA47B9F1" modified="2024-11-27" version="1">MIEGHPQVRYTTNDNVILRRQEPNYTVTRKDLKTHEETIFTVIDRSDEKMKDDMIAAFNTSSVVNGIKGISPLMNLSYVGLVSAFTIDYMHCVLLGVVKKVTHLWLDSTSHDKPYYIGKKTSDVDNRLTKIKPPTYISRRPRSIVDRAYWKANEFRSWLLHYSLPCLAGILPYVFLKHHCMLATAIFMLLQQDVSSDIIETASWYLAQYVLEFQNLYGELNMNFNLHLLLHLGKCVEKYGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZA5</accession>
    <name>A0AAV6TZA5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000849">
        <property type="protein sequence ID" value="KAG8176831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZA5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF23">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="139" mass="15508" checksum="18D0E736E0C1575D" modified="2024-11-27" version="1">MSRQVQTKIVTEVKEANYFGIIVDSTPNLTRIDQLCVVLRYVDATNEPVERFITYVPIHSHAAAHLYDTILALRSNLQLDLKYCPAQWYDNAFNISGKYAGLQARIKSVYPLTEYVPCTGHSLNLVGVNAVESCQAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZS9</accession>
    <name>A0AAV6TZS9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo repeat-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_020023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000812">
        <property type="protein sequence ID" value="KAG8177148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZS9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000061">
        <property type="entry name" value="armadillo repeat-containing protein 8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000070">
        <property type="entry name" value="armadillo repeat-containing protein 8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8177148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="730" mass="80886" checksum="BA351FDD94E45EBD" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U152</accession>
    <name>A0AAV6U152_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_015930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000783">
        <property type="protein sequence ID" value="KAG8177376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U152"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968:SF14">
        <property type="entry name" value="PROTEIN KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968">
        <property type="entry name" value="PROTEIN KINASE C, MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="3">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8177376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="138" mass="15220" checksum="E692B7D02474B4D9" modified="2024-11-27" version="1">MVRRVHEKNGHKFVATVLRQPTFCSHCKGFIWGIGKQGYQCQDCTCVVHKRCHESVITNCRSSTDATTNEAPDVGSSPHQLSVHTYMKPTFCNHCGTLLYGLIKQGMHCGGCNMNVHKRCQKNVANNCGVNPAVSNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U1K8</accession>
    <name>A0AAV6U1K8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000778">
        <property type="protein sequence ID" value="KAG8177444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U1K8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="152" mass="17122" checksum="787DAC1719073750" modified="2024-11-27" version="1">MKKQPREKAAQSIPKITSFCLAPIKTDTVSPISLTPIDATSENLKDNKADEQTKHENLKENNISKDTTSENCTDNDFNESVYENFKENIETSDTLAINLKDNSITSDCEQVLPMDSELVENFSRNFEPPDSTPLLVSARHLTAVLKYDARRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U383</accession>
    <name>A0AAV6U383_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000693">
        <property type="protein sequence ID" value="KAG8178478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U383"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8178478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="11044" checksum="F50E9146339C586B" modified="2024-11-27" version="1">MYFIKNSQGHLYHKLSPIREEKCEEIKAADIFECFISKKKRVLRNTQNQANATKICGDLFPLNEYSLPSSSDDQKLIKVLQELTLYTKYKKIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U3V0</accession>
    <name>A0AAV6U3V0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_025595</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000676">
        <property type="protein sequence ID" value="KAG8178673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U3V0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8178673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="538" mass="58283" checksum="D43594FC5B9CBF95" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U437</accession>
    <name>A0AAV6U437_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_014018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="JAFNEN010000654">
        <property type="protein sequence ID" value="KAG8179017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U437"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="39"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8179017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="469" mass="51346" checksum="C235BA60877F2B73" modified="2024-11-27" version="1">MALAENNIPHGQPQLKRQDLANLDVNNLTPLTEEVISRQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLGYANAKIYKCDHEGCPRPACYRSARSSKEDDFPCDRIGCPGRFRLLRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYQQILKFVQGTVAEGAPVVPISAQLKYNIEVICEYIVKKIPVPLRDFTSEPRLIVIRSFDVNKPGCEVEDLKGGVAGGSILRGVLKVGQEIEVRPGIVTKDDEGKLMCKPIHSRIVSLFAEQNDLMYAVPGGLIGVGTKIDPTLSRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKGAKVQKLAKTEILMVNIGSLSTGGRVLAVKADLAKISLTNPVCTEVGEKIALSRRIEKHWRLIGWGMIRRGVTIKPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5M6</accession>
    <name>A0AAV6U5M6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000641">
        <property type="protein sequence ID" value="KAG8179260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5M6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="555"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="716" mass="81982" checksum="D052E29B10D87BF3" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U5N3</accession>
    <name>A0AAV6U5N3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_015342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000646">
        <property type="protein sequence ID" value="KAG8179153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U5N3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="83" mass="9602" checksum="ED47D557707A4390" modified="2024-11-27" version="1">MESKEEVSKETVQSDDSREKPTDTECTSDRESSVESFHTNKSELSTTSESEQRPISDLIDIDDIELSDEESWLYKSPKKYHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U672</accession>
    <name>A0AAV6U672_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_024073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000602">
        <property type="protein sequence ID" value="KAG8179797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U672"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8179797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="109" mass="12502" checksum="6E6E5C2BA00BFA53" modified="2024-11-27" version="1">MPLAILRDFNFHHQEATEIGGFQFHYPPYGPAIPCGHAHNNASNFVLEGGFVYCFEVVDVSKDSLKVEKNIKVYKELEPRKRNQDSATIFFLGKTKKERETMGKTTYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U730</accession>
    <name>A0AAV6U730_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000565">
        <property type="protein sequence ID" value="KAG8180372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U730"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8180372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="8044" checksum="02D5B914ECAB3859" modified="2024-11-27" version="1">MLKSFPYVYFAVYFVPLIPKKEAEEVIRIITSSLNSRKEFSDEMSGRDPEFILETSGSSLEHLEQGMIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U782</accession>
    <name>A0AAV6U782_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000606">
        <property type="protein sequence ID" value="KAG8179728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U782"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="75" mass="8492" checksum="EB22B1CA5D29FFE5" modified="2024-11-27" version="1">MKYLSANGEETPTSLKAKQGKILTIDKALETKRKRLSSPLPLFCKYIDDSSQKQEKEEISVVSEKIDTPTQVHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U8S8</accession>
    <name>A0AAV6U8S8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000558">
        <property type="protein sequence ID" value="KAG8180660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U8S8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="10532" checksum="2060B4DFE53B6D41" modified="2024-11-27" version="1">MPGCNDFDSHSTSGSATHTIPRPKTHSACSEHPAREKFSPGKRLHEKGSTFALENKSGIVWRSLNGQPRGDVERGGAADAAQISSERFDPGGLRFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U932</accession>
    <name>A0AAV6U932_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CD109 antigen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_025423</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000565">
        <property type="protein sequence ID" value="KAG8180373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF172">
        <property type="entry name" value="LD23292P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043316542" description="CD109 antigen" evidence="4">
        <location>
            <begin position="19"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1540"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="5">
        <location>
            <begin position="476"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="6">
        <location>
            <begin position="746"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="7">
        <location>
            <begin position="1419"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="705"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8180373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1563" mass="177242" checksum="733A20DCAFEC137B" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UBU8</accession>
    <name>A0AAV6UBU8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_013953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000483">
        <property type="protein sequence ID" value="KAG8182022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UBU8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043820798" evidence="2">
        <location>
            <begin position="31"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8182022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="215" mass="24201" checksum="701C0DBE97534A7A" modified="2024-11-27" version="1">MLPKAGVLFFLVSFLAVFLGIGATLPSTLGQGSRRPGYVPGHQNPYNPGYPHRPGYPSRPGYPHQPSYPGGHDVYPEDDCKYGRPCDDEDHDLGGYDDGYGDDQSGYGQSGCSCILRVDHTVVFRRVNNRQRFQCNRYGLERCSRYCDELFQDDRLRVGSRQDACDVMGRDVFVPWYRRDQVCGLGGAYKDVPLPLDLCCKRGRPSLDCEDDYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UD84</accession>
    <name>A0AAV6UD84_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JTE90_017118</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000477">
        <property type="protein sequence ID" value="KAG8182164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UD84"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-0229">DNA integration</keyword>
    <keyword evidence="11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="12">
        <location>
            <begin position="53"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG8182164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="349" mass="40244" checksum="3A5743867E81B32B" modified="2024-11-27" version="1">MRGKWTFRSDKNERHLFQNFFWPQCYKEIEDYVRSCDRCQRVGKPFDKKKAPIKIVPVIQEVFSKINVDACGPLPVTPSGKKYLLTAMCLSSKYPDAVPVEDITSVTVVDALMQIFSRMGFPKILQLDQGSSFTSALSTTFLEKFGIKVVHSSVYHPQSNPIERFHRTVKRVLKVLCLESVSDWEQAIYPALFALRTVTHESTGFTPAELVHGKNLRTPLTLLYEKWLDVEETEGEPVTEYVFSLINRMKRCQELAISKMEECQQKNKTWYDKRAVKREFRIGDLVLIFATFKSNKLSPHWTGPGTILRKLSETNYVVQLPGEKATSKVYHVNMLEAILTTRRSELFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UDX0</accession>
    <name>A0AAV6UDX0_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_007309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000459">
        <property type="protein sequence ID" value="KAG8182572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UDX0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="161" mass="18173" checksum="7B8AB2B64AB80B8D" modified="2024-11-27" version="1">MAISWSTPKKNAERGRDGGAALVYLCQTKTGAWDLGTRSPRVYVKGRGADRGALDYDAEEGLFWSNWKEGTINSYIPSTNKQDEILTTSVRPHYLRWNWIAKNIYYTDDEGSIVSCSRDGKYCTTAIQNIAKHINSFDISPTTGLMFWSLWELVLHRGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UE74</accession>
    <name>A0AAV6UE74_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000470">
        <property type="protein sequence ID" value="KAG8182294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UE74"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="97" mass="11534" checksum="9A8625E958839C15" modified="2024-11-27" version="1">MVNSHFFIYTNNSLSLKERKSERFSSVTATLTLNKGRHGCRRSRPTVPFSINLLKLFCLRKIMELDVDDNKPKKWTGVSSVRRHVWVYRVERFQDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UG05</accession>
    <name>A0AAV6UG05_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_003332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000439">
        <property type="protein sequence ID" value="KAG8182954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UG05"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8182954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8174" checksum="B9653D3512C5AB65" modified="2024-11-27" version="1">MAWKSISRTLSVERSLGMGPGLKPTVGSWVKVGWAWVLGIVVGYRRTPPAVFRLIPLKGSTPNGLQDNILFVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGL0</accession>
    <name>A0AAV6UGL0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JTE90_000440</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMTC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6"/>
    <dbReference type="EMBL" id="JAFNEN010000445">
        <property type="protein sequence ID" value="KAG8182833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGL0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44395">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44395:SF1">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13431">
        <property type="entry name" value="TPR_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 16" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="18">
        <location>
            <begin position="255"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="560"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="594"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="665"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG8182833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="822" mass="93783" checksum="A4291F96C9381270" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGN5</accession>
    <name>A0AAV6UGN5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Activating transcription factor 7-interacting protein Fn3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000416">
        <property type="protein sequence ID" value="KAG8183462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGN5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056565">
        <property type="entry name" value="Fn3_ATF7IP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16794">
        <property type="entry name" value="fn3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activating transcription factor 7-interacting protein Fn3" evidence="1">
        <location>
            <begin position="87"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8183462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="175" mass="20086" checksum="5F2BE7D1D968D414" modified="2024-11-27" version="1">MEDTCKKAKAETQCKVEIKKEPLENQEEANPSQVFPMETQCKVEIKKEEPLENGEANSSRDQSADSLLILRQVNHLAPFPPLPPLDNIPPKPLVKAYCRDRDIVLEWDMPNCAPDNRNHAPLTGYAIYFYEGQKNIPVTGPLWKKFGRRYIPKGMNVKLVSEKEEWKRMYVGSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UH22</accession>
    <name>A0AAV6UH22_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">B-block binding subunit of TFIIIC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_003329</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000439">
        <property type="protein sequence ID" value="KAG8182951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056467">
        <property type="entry name" value="eWH_GTF3C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056428">
        <property type="entry name" value="WH_GTF3C1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24101">
        <property type="entry name" value="WHD_GTF3C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23704">
        <property type="entry name" value="WHD_GTF3C1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="General transcription factor 3C polypeptide 1 winged-helix" evidence="8">
        <location>
            <begin position="44"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="210"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="GTF3C1 extended winged-helix" evidence="9">
        <location>
            <begin position="604"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1086"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1090"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8182951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1971" mass="228437" checksum="2FBB2BF8E5B2D428" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHE2</accession>
    <name>A0AAV6UHE2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MiT/TFE transcription factors N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_005662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000427">
        <property type="protein sequence ID" value="KAG8183213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHE2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031867">
        <property type="entry name" value="MiT/TFE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF2">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15951">
        <property type="entry name" value="MITF_TFEB_C_3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MiT/TFE transcription factors N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8183213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10847" checksum="F791A444CAC5EAFC" modified="2024-11-27" version="1">MLNRTVFKQLLMRKQLQELKMKEQLEEEQLPFSFSSPPPSSPPQQPPPPRNVQVPGQVLVVHTQLENPTAYHLRETQRWQVRDYLLSQSSQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIL0</accession>
    <name>A0AAV6UIL0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Membrane metallo-endopeptidase-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_003859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000414">
        <property type="protein sequence ID" value="KAG8183508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIL0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF224">
        <property type="entry name" value="NEPRILYSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="115"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="564"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8183508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="87668" checksum="497C5B6C526B93B8" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIL5</accession>
    <name>A0AAV6UIL5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000391">
        <property type="protein sequence ID" value="KAG8184015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIL5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="98"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="263" mass="29919" checksum="40FE62E7DB2DD2ED" modified="2024-11-27" version="1">MQHSFSVVGSDGKIFRHIGVATFTYDEQNKIFDSEVYPKKISEFCNSTEDQIVIFKWVLGIPALTTKNACRHLPQSSFDLLPTIIEDFKSMFSDSLYTDLTLSVGNRVLRVHKSVLCARSPVFAKMLKSPMDEKEKDVITIPDIDLPILKTFIEFLYSGDMPDAEFETACALYYAADKYEVPSLQKECANVLLDKLDIENSCQVLALANRHSDEELKGLVLHFMQSEFDAILGTDSWMDFVKVETDLAVEVMKLRAQKFEKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKC8</accession>
    <name>A0AAV6UKC8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_001082</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000380">
        <property type="protein sequence ID" value="KAG8184263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKC8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12358">
        <property type="entry name" value="RRM1_VICKZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8184263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="13409" checksum="1F452A2A5D19C778" modified="2024-11-27" version="1">MSETETKVEMTNNKLYIGNLAPTVNEDSLRDLLKDKSGSVPTSVLVKRGGYAFVECKDPAAAEKAIESLNGFSFMGTELLVEPSVPQNKRMFNLEESKFQLFGANCDHNGKPPVLLNKRTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKF3</accession>
    <name>A0AAV6UKF3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_022672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Promotes neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes and thus regulates SCF-type complex activity. Function promotes cell proliferation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000367">
        <property type="protein sequence ID" value="KAG8184622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKF3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000030">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000002">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF12">
        <property type="entry name" value="DEFECTIVE IN CULLIN NEDDYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="5">
        <location>
            <begin position="87"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00059219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8184622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="292" mass="33898" checksum="6ACADAC9B6D55648" modified="2024-11-27" version="1">MFSVRVLRIAHCTRTHLSQLRVLSLTEGSSEQSPGAREAPLSSTAMPPQRRKRAEPTEDPKSNSKRPRMHNTSRKSFKIAEIVDSSFSQKKCIALFHEYAPPNDPETIGPEGMEKFCEDIGVEPENVVMLVLAWKMEAKQMGFFTKSEWLRGLKDMECDSIDKIRNKIDSLRSLLNDPGVFKSIYRYAYDFARDKDQRSMDIDTAKAMLQLLLGRMWLHYSSFHQFLEQSKYKVINKDQWCNVLEFSRTIKSDLSNYDEDGAWPVLLDEFVEWLSLQQNFPNLKQSFSNSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKM5</accession>
    <name>A0AAV6UKM5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_025724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000402">
        <property type="protein sequence ID" value="KAG8183841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKM5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF438">
        <property type="entry name" value="PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="149"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8183841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="472" mass="53678" checksum="D051C40F79445724" modified="2024-11-27" version="1">MKLFAANGTSIPTFGEKLLQVDLNLRRSLPWPFAIAAVSHPILGAYFLKNFGLLVDMKNNRLIDTSNGRKVSAPVIASSYGTISLLAQDSKYKDLLSEFPEIIKVSNPVKINHQVEHHIETTGPPVFSRARRLTTEKLAITKQEFQYMINQGICRPSKSSWASPLHMVPKKDGDWRPCGDYRRLNNITKPDRYPIPHNHDIAQQLEGKTIFSTIDLFRAYHQIPVREKDIQKTAVITPFGLFEFPFMSFGLCNAAQTFQRFIHSILQDLDFCTAYIDDVLVSSKDEKEHMHHLRLIFQRFQEHGIRINPSKCNFGQPEVNFLGYRITAQGTQPMEDKPITTNIQHVKGEANVVADTLSRILTIDTPSPIDYQKMAEIQKEDKELQDLLNRPEGTSLKLQPMQFQNSNLYCDTSTGWADALPTVLMGWRATYREDLTATPAQLTYGTNIKLPGELFTESKMKTDQSTYVADQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UL85</accession>
    <name>A0AAV6UL85_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sedoheptulokinase</fullName>
            <ecNumber evidence="10">2.7.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Carbohydrate kinase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_017027</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a modulator of macrophage activation through control of glucose metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>sedoheptulose + ATP = D-sedoheptulose 7-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16802"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.14" evidence="10"/>
    <dbReference type="EMBL" id="JAFNEN010000349">
        <property type="protein sequence ID" value="KAG8185001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UL85"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050277">
        <property type="term" value="F:sedoheptulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07777">
        <property type="entry name" value="ASKHA_NBD_FGGY_SHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000111">
        <property type="entry name" value="Sedoheptulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000132">
        <property type="entry name" value="Sedoheptulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF67">
        <property type="entry name" value="SEDOHEPTULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="13">
        <location>
            <begin position="10"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8185001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="466" mass="50701" checksum="630EDCA4E6D787D2" modified="2024-11-27" version="1">MADQARSALVLGIDIGTTTVKACLVAADTKKVVESASRETKASTSSDQGPLGSEQDVHKICTALQFCVSRMPKEQLVRVTHIAVSGQMHGVVMWKAGQGWRRNNFGRYETETVSCLYTWQDARCSSEFLRALPAPDSHLRVSAGHGCATLFWLARHRPALVDEYDAAGTVQDLVVSMVAGMTRPVMSAQNAAGWGYFDTETRSWNTDKLKEAGFPVHLLPDVTVAGSVVGHMPCSWYGIPEGTPVYAALGDLQCSVFSSMETEHDAVMNLSTSAQLSILLPEGFKPPPSVSTAPVEYFPYFKGRYLAVAASLNGGNVLAAFVKMLQQWTHELGLGVPESKIWERITALAQDDSSADTEMCVVPMLFGERHLDEHQRALVSNIHPHSLGLGRVARALFRGLIANIREMMPREILLEHGITRIMGSGTALTKNPVLQRELEQQYDLPVVYGTSTDAAVGVALAVLPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULQ4</accession>
    <name>A0AAV6ULQ4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000342">
        <property type="protein sequence ID" value="KAG8185224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULQ4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="448" mass="50137" checksum="D3811661104377D1" modified="2024-11-27" version="1">MASIGRWLYRQIFKCIPCLKPAKKAVETKDYTEDPNVFGDHGNHNEYPERLNPFKEDEEERKAQEYNVYPEDLNPFNDDEKGQNQQQENEYPEDLNPFSDEKEEIIQQENEYPDSLNPFAVEYVNKQQQKNDYPEDLNPFANKKETSLPPSAKTDTNTDKTLKLFVSDDDSVVEKISPNEESASGALKISGHVLLKYKVSEYDESLNPFASEDEETNANTGVTEAINGSSSLNPLPNEPKTDAYQEALKLFTSDDEEDIVDIIVQQSSLTIAYHQTSPTINISSSSYPLPNERRKGKSKKKYRAPGPPVNVCIMPNAESSPAASETLGLVPLMDKVHEYDESLNPFTSVDEGNTEDATENSPSQLKIATINSSSSLNAVLKERKKGKTIKKRRAPDPPKIETCVPNEESVSGDSRDIRPNESCESSSHPGATKSKAHIKEACPSIYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMI6</accession>
    <name>A0AAV6UMI6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_002303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000372">
        <property type="protein sequence ID" value="KAG8184456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMI6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="62"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8184456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="385" mass="43166" checksum="BDFDAEF36540CDA5" modified="2024-11-27" version="1">MVMGYKAKLFNLRYNGHSMYILDRCIAGTDVEYMNLKRDTDSRRGSHGLRLLPNGLINETDSKSEICAFTDGSKTETGVGAGIVIFKGATPLLVDRLKLRPDNSVFQAEATAILKTVEWFVSSRFHNIDIFSDSMSSVMALASLYPKSPIIKDIKDLCSDLGNREINIFWIKAHVGYFGNEFADALAGSAVEMGRGANQAKIPLSFVKRELKIILNKEWQRDWESSEKAILSRTPLGILKKANIRIRDFIRKALHLPKDCPNAYINANVDDGGLGVTSLRTKIPELRLKRLEKLKRNMPEEAIGGSAGDFLMYNIKKTVDNCVGTFGRVYWKDNLCKSVDGTPLQVSVSSQKCTLGWRHRTHLWSGVTLLTRLNYASTHYRLILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UML0</accession>
    <name>A0AAV6UML0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_018643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000336">
        <property type="protein sequence ID" value="KAG8185425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UML0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8185425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32120" checksum="0FADC47EACE814C6" modified="2024-11-27" version="1">MDGKLVSGRQHGQQGTISPASDFNAENTLLKDDIRAELGGHFEDVCIALLTPLAEYIVDCLYFAIKGDKVDENCLKEILVSLEFRDLCYVKSIFKEKYNEELVDFIESSVTSETKHLMSALLSNERQCSNDIDEQMAMDNATYLYNEGLSKSWKSEEFLINLLATHSKMQLQATILSFKKIAGYTLSEAIKSEFSGCTRDALLSMLECIENRVAFFATQLYEALKKPKTDDATIIRILVSRSEVDLADIYEWYHIKYDIDLCEAIYADTSGDYRTILLKILNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMN4</accession>
    <name>A0AAV6UMN4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-cysteine N-palmitoyltransferase Rasp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_018634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the membrane-bound acyltransferase family. HHAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000336">
        <property type="protein sequence ID" value="KAG8185414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMN4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043921974" description="Protein-cysteine N-palmitoyltransferase Rasp" evidence="7">
        <location>
            <begin position="19"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8185414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="57542" checksum="C11169CFF6E01289" modified="2024-11-27" version="1">MWIEKKIYLAVWIISISAALVSFSKSCKNHPKEFPDDFGEGWQFLERQQDQSDIEWAVLTSLFKEYWFILVVQIICTNLFFQRSKARMLFYAMYSILALTLIVGITISIVFLMYILLMFCIHLTGKKQYCYLLTIVSLFLVHHTRFFNLKEFLLIEMERDLFLFDVGLAWLLSKCLSFAVDRIDAKRNIYNVSDISMVLTYCLFLPAFFTGPLIAYESFHTEMLKNERDTLSSKNILLNTVYLLYQLSYYFVYEFLLHFMYSSSISYYPEIVANFDRWSLCGLGYALPMMFYLKYFILFGIAGSLSRFEGITLPPPPKCFTTSYLASFLYRHFDRGLYLWLLKYLYLPMLKIGLGRISAQSLCFAFVAIWHGSDAAICISSVLNWLLVASEVIAKHLSTSKIGKKIQKLPSDMHGRFCAALATPHFILLCISCDFFLSNYEIGALILNQMVIRFELIPLAFLLCIMYCGCHVSIDVKKFQEKGPLSMNFILDKGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UN74</accession>
    <name>A0AAV6UN74_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centromere protein CENP-B C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_028908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000321">
        <property type="protein sequence ID" value="KAG8185910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UN74"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17569" checksum="13D5B678AF0EE1D8" modified="2024-11-27" version="1">MHFISALWRNVTQQCILHYFEETGFTASNEPGTNKETAAVDSEEDSETVIYDFDDYIPEKLVKCEAERATAPSVADLMDFSSANEDQQEEPEAQPVPSFNIAMKSLQIVKDYFLSYGDQEKNLQSISILEDAALTLNSMTKKQSTITDYFQSKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UNQ2</accession>
    <name>A0AAV6UNQ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000321">
        <property type="protein sequence ID" value="KAG8185899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UNQ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="9713" checksum="3043780B2056A74D" modified="2024-11-27" version="1">MASKTLGAKQTIIYSPNVVTPENCSTLIEGGVSSSHLDGKWGMNLTRWHREEPFPSCLTCRHPPFSADFTCISLLFFLNRGGGVKELGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UP98</accession>
    <name>A0AAV6UP98_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000332">
        <property type="protein sequence ID" value="KAG8185544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UP98"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="496" mass="54627" checksum="1D2EF482F98AEBA3" modified="2024-11-27" version="1">MVRSGNLTDANCGAQPSMMEKLPTHKCARYLSNTILDHYSGNVEVAPNCVLACRVPPPRTYGCVLSSRAPPLLTSSWIISRSPPLDLQFCPLLQRASSLGLQLCPRLQSTSTLDLQLYPLLQRTSSFDLQLGHLLQITSPRPPVLSSPTERLLPEPPSAFITSIYSITKLSLTFWPVEILKITPLVATSCSCMKEPPASLSLQLCARLQRTSTPDLQLCPLLQSTSSFDLLLDHLQIISPGPPVLSSPTESLLPEPPVVCSPAESPPLDLQFCPLLQRASSLGLQLCPRLQSTSTLDLQLCPLVQSTSSFDLQLDHLLQITSPGLQFCPLLQRASSLGLQLCPRLQSTSTLDLQLYPLLQRTSSFDLQLGHLLQITSPRPPVLSSPTERLLPEPPSAFITSIYSITKLSLTFWPVEILKITPLVATSCSCMKLGKSSRPFKTSIIIVIGDCNPTKTPQATPRIKIPREIKDFRTFKDIATNCHLKLYKMIFDKKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQB4</accession>
    <name>A0AAV6UQB4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_000733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ZNF277 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000325">
        <property type="protein sequence ID" value="KAG8185750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQB4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040048">
        <property type="entry name" value="ZNF277"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13267">
        <property type="entry name" value="ZINC FINGER PROTEIN 277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13267:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8185750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="341" mass="40734" checksum="DF42E857C5E28D38" modified="2024-11-27" version="1">MEVEDVEERVRVLTLDAHRQHSPSAEIPCNSEQCYALLDTNSADKEKLQEERLRYVLCQLQREREDIHFSRDCIFCKKPFTGNRSVLLDHMMEQHNFLIGAPDNIVFINELLDHLEQMLKDLKCLYCEKVFRDQTILKEHMRKKQHKRINPQNKTYDRFYLINYLELGKTWKEVQEEEYGVSQEEDEKEMMDFEDEDLVFVCLFCEFKESDSDKMFLHMKNDHMFDFKQLKETHKLNFYHQIKLINYIRKKVHEKECISCDLKFNFQVDLLRHMAESGHAASLPEKGDWDQPSYYFSTFENDNLLCALDVEDSDCQECLVFPEDSALPTNFCEEMLSIHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UR24</accession>
    <name>A0AAV6UR24_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_025198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000290">
        <property type="protein sequence ID" value="KAG8186756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UR24"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="7920" checksum="817EAB831C324853" modified="2024-11-27" version="1">MLRNIYPTTTHFPTFQINPISPLQIPSKTSIPEASEGLLITYPNPGILPGSIVGHNTRAAHPHTTAANNCSDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URL9</accession>
    <name>A0AAV6URL9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cyclin-dependent kinase inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_009237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000300">
        <property type="protein sequence ID" value="KAG8186482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URL9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003175">
        <property type="entry name" value="CDI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265:SF45">
        <property type="entry name" value="DACAPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02234">
        <property type="entry name" value="CDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-dependent kinase inhibitor" evidence="7">
        <location>
            <begin position="33"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8186482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="149" mass="16929" checksum="FAFF700127328B04" modified="2024-11-27" version="1">MGDVAAVGVLRNNTSSGPGWNVGPQRSAGARRCLFGPPDPEKTREFLQSETERIADENKLKWNFDFVAEEPLDCGRFAWSKVSETDDQKDDNKVQTRITDFMRKRKLPSHHPKDEPTSSERPKKEPKSSEDESTSSEEPPTKCMRRFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6USI9</accession>
    <name>A0AAV6USI9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000289">
        <property type="protein sequence ID" value="KAG8186782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6USI9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="74" mass="8354" checksum="F9D3A6E4EACE70CE" modified="2024-11-27" version="1">MTSNSSFKNESQYLESFENEINILRVPTNDKRLQTSIDLLPTNYKNPKPPLNPASLQHTLPKKKDGPSFGGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTM5</accession>
    <name>A0AAV6UTM5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_020027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000277">
        <property type="protein sequence ID" value="KAG8187149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTM5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF291">
        <property type="entry name" value="IP11374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8187149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26391" checksum="D550CA65C78DC407" modified="2024-11-27" version="1">MSQSFKTKIISYFFTSKTTNDNDQTLTSSTSLLGKPASKSVQLGSKKQTRLEPLVSLSLPPALKDLEKGDFVKVCEEFDVSVSVLEINTRKHDVSHSFCLKLFHILVFCKIYISYDYKKTSQSPNHDRVSGGMKRQNVRTLSLIVCTFTYLLIGAAVFDALESENEQVQRSTIRYVEKLLVSKYNISAEDYRIWSTIIIKSVPHKAGIQWKFAGSFYFATTVLTTIGECNIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTX7</accession>
    <name>A0AAV6UTX7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_019182</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000275">
        <property type="protein sequence ID" value="KAG8187293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTX7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF117">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="133"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="486"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8187293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="515" mass="58420" checksum="46AB9EC04BEE3653" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU55</accession>
    <name>A0AAV6UU55_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000275">
        <property type="protein sequence ID" value="KAG8187288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU55"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043439933" description="Secreted protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8187288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11569" checksum="DA4AAE4B9442887A" modified="2024-11-27" version="1">MFTGRYIPIQLFSVWIYILRCIFRLGCVFEAPGEPPEYQPVLWHHSGTSICRFHFCAYCASLGGHELHWIKTKTHSRCQADKLLYFKPTCNHCSISNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUE4</accession>
    <name>A0AAV6UUE4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000272">
        <property type="protein sequence ID" value="KAG8187442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUE4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8187442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="96" mass="10503" checksum="E41194315F4808BA" modified="2024-11-27" version="1">MPLKSDSDRVIEACPDTGASNYFERLVPHPRRLRAALQASNPDIMPLKGVSDLVIGACHDTDDAAGVAIVFSRWLDLEKKMVDASDSSARKVIQDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UUI5</accession>
    <name>A0AAV6UUI5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine aspartase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_000389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000284">
        <property type="protein sequence ID" value="KAG8186916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UUI5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="15"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8186916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20189" checksum="D07896C488DCDA24" modified="2024-11-27" version="1" fragment="single">VTEYNSTPNNNSLLDTVGAVCVDDSGTVSAAVSSGGLLLKIPGRIGQAATFGAGCWAQNSTTTDKPSIACSVTGVGEYLIKTLFAKECYQTLYDRQDSISALPDVFRDSFLDSPYLRNAPNKQAGVVVLKHYRAEGLCELAWAHNTKTMVLGYGSTSKGKVVSILSQQPPDTEVSKYGIVGGEKCLRLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UWG2</accession>
    <name>A0AAV6UWG2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000237">
        <property type="protein sequence ID" value="KAG8188519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UWG2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8188519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="8845" checksum="36B5716C9FD924CB" modified="2024-11-27" version="1">MRTGSALAGHCGGYSKRPKAGHFGGCSNKSKAEHSGPGECWNKPMTWQECDRDVLLRSGVRVRIDNTDSLEKPEIFVVGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXK7</accession>
    <name>A0AAV6UXK7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000220">
        <property type="protein sequence ID" value="KAG8189157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXK7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8189157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="100" mass="12190" checksum="EDB787B3FB1D1774" modified="2024-11-27" version="1">MSKTRSKRKHRINRRTRRTTREIPRVEVNPVHVYVYANNVDYYCDMYLADVRKGTEKYSTKHHGKSIPTRKYKAFSEKAENRHFRKVCEDARKIERMNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXU1</accession>
    <name>A0AAV6UXU1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000248">
        <property type="protein sequence ID" value="KAG8188161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXU1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8188161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14258" checksum="82C147C0127E0C03" modified="2024-11-27" version="1">MIWLQGEGEVHQLDLITYLCGSINSESYPVSENIPVFASLRLPRNRRKLSRSIKHFVKNDYAMYLIDQLLTLDQNSRISATAFLSHQFFEAEMPCDLADMGLRFCQAMEATSGNSSSFCAYYITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UXZ0</accession>
    <name>A0AAV6UXZ0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_018462</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000220">
        <property type="protein sequence ID" value="KAG8189171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UXZ0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0558">Oxidation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8189171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41658" checksum="FCEA8F374E2AC6EF" modified="2024-11-27" version="1">MCDDDVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGNKDSYVGDEAQSKRGILSLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSAEKSYELPDGQVITIGNERFRTPEALFQPSFVGMESAGVHETTFNSIMKCDIDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPAIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UYR7</accession>
    <name>A0AAV6UYR7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_021862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000217">
        <property type="protein sequence ID" value="KAG8189359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UYR7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8189359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="210" mass="23074" checksum="E3B54141984FA07E" modified="2024-11-27" version="1">MAQLHVLQKLLPRSVNAIFTSCRHPASVFSHPVSSFYCRKFSSETMAKTTVFFDMAADNQPLGRIVMELRPDIVPKTAENFRALCTGEKGFGYEKSTFHRVIPGFMCQGGDFTAHNGTGGKSIYGSKFEDENFILKHTGPGILSMANAGKNTNGSQFFICTEKTAWLDNKHVVFGQVTDGFDVVKQIEKFGSQSGKTSKKITIAKSGQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZB8</accession>
    <name>A0AAV6UZB8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_026156</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000202">
        <property type="protein sequence ID" value="KAG8189855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZB8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="13">
        <location>
            <begin position="29"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8189855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="425" mass="48266" checksum="DC82CC095F8EA36F" modified="2024-11-27" version="1">MKFPKFLRVAVVPRAGIFQVNRTNSGKLQVVGGDESEFLELLSKALKFDYELIIPDIGAWGDMVNGTWTGVVEMVHQGYADIAIGKTSITYERTTVVDYSQPYDMEHLTFATNIPGHLPKTDSFLMPFDATIWSAVLVMFIVFAIAFKIILPKKPFQWTILQLLRYILYQPLLDIVATKASSSILLFTWIVFVRLIPMYYSTALLSYLTIPEQGQGIEDVRDLGKRIMLGTYKAVTFADSSYIFTMKSSGNDYIRATGEAIEQNDWFVLPDKKSVSNVLKNDDTAVIAPRRFLKRNLNNVHISRDVFVILTRAIVLKKNFCCSDILNNYLLRICAGGIYWKILNDAMFLEQLSSRAAETFQEDPPVKNLTMEDVSGAFILILAGYVLSALVCILEVIIFKIKRQKKVCRKVVGRFRKKKIRKIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZL9</accession>
    <name>A0AAV6UZL9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_013776</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000219">
        <property type="protein sequence ID" value="KAG8189248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZL9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF7">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043596795" description="TM2 domain-containing protein" evidence="10">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="11">
        <location>
            <begin position="210"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8189248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="276" mass="30634" checksum="E72D79C63A8DBF77" modified="2024-11-27" version="1">MSRATEVTFIFLIVLCIGGIGERSANRRTIFAPNSSHALRHSATRHMLSHVEGGDNASSFAIDYTKLFSDSLIQQTASLRSESNRTSTSSLTADPSSDGCNTNLPCSALIGNCIKCTYNYSCVYGEDTSIKCEATKFAKCQGNRTFYKTHNCRYCYQTSRDDHTCQRNTSCHVISSPRQRYVTKCTVKSHVLCLGNRNFSKHVPCNWTKGYRWGTALLLSIVFGGFGVDRFYLGMWQEGIGKLFSFGGLGVWTLVDVILIATGYLGPADHSLYIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V095</accession>
    <name>A0AAV6V095_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="3">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_009078</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000199">
        <property type="protein sequence ID" value="KAG8189937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V095"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004706">
        <property type="term" value="F:JUN kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12059">
        <property type="entry name" value="SH3_MLK1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14061">
        <property type="entry name" value="STKc_MLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000076">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000085">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035779">
        <property type="entry name" value="MLK1-3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF293">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="108"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="452"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="700"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="791"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="855"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="717"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="824"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="900"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8189937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1004" mass="112840" checksum="A25E37CDD881BCE7" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2L0</accession>
    <name>A0AAV6V2L0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_006029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="JAFNEN010000194">
        <property type="protein sequence ID" value="KAG8190089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2L0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8190089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="289" mass="33225" checksum="AD1DC1F98E25D110" modified="2024-11-27" version="1">MTDIDKWVDIAKDCKYLPENDLKKLCDIVCDLLLEESNIQPVFTPVTVCGDIHGQFYDLEELFRTGGTPPDTNYIFMGDFVDRGYYSLETFTRLLTLKAKWPDKITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCCKVFDLLTIAAIIDDQVLCVHGGLSPLIRTLDQIRTIELWSDPEDVETWSVSPRGAGWLFGAKVTHEFMHLNDLKLICRAHQLVHEGYKYMFDEKLVTVWSAPNYCYRCGNVAAVLAFTDVDTRKPKLFSAVPDSERVIPSRVTTPYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V2R4</accession>
    <name>A0AAV6V2R4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_009061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000199">
        <property type="protein sequence ID" value="KAG8189916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V2R4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019202">
        <property type="term" value="F:amino acid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050249">
        <property type="entry name" value="Pseudomonas-type_ThrB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064:SF1">
        <property type="entry name" value="HYDROXYLYSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8189916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="113" mass="12776" checksum="EDC4982FA7D5DD21" modified="2024-11-27" version="1">MHHGPYAWDLGMLLGHALLVKKMLDPLEAVGHAVAGYQSVRRLSEKELSFLKMVMECRICMMCLISTVVHKDPSNSYIAMMAALQPKIEVFKLLSNVDNESYLKIYGDYTNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V396</accession>
    <name>A0AAV6V396_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RNA cytidine acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_003260</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000162">
        <property type="protein sequence ID" value="KAG8191247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V396"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="11">
        <location>
            <begin position="8"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="10">
        <location>
            <begin position="242"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="473"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="13">
        <location>
            <begin position="694"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="920"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8191247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="945" mass="106757" checksum="16FC255C6117393C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V6M0</accession>
    <name>A0AAV6V6M0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytokine-like nuclear factor N-PAC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glyoxylate reductase 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_006103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000161">
        <property type="protein sequence ID" value="KAG8191358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V6M0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="6">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8191358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="450" mass="49615" checksum="122A2034738518FE" modified="2024-11-27" version="1">MDLRVNDLVWAKMKGYPAWPARISEPKKGHKRLHHYVYFFGTNNYAWILDEHISHHSQELVDAALQKKNVSSPLKAAVEEIVAEAKLNPPSVARQLALKYRKLKEVRSKLKAPKKKFFGVPTLQVHKKGRVRADPYEFDDESSSLPRVPHVPPTTQHIGFIGLGFMGRHIVRRLLETGHHVTVWNRFQERCDEMARRGALRAACPADVIAACDLTFCCVAGPEASKAVLFSHDGVLKGLERARKAGSPDKGYVELTTLDDATSQEIGEAVRFQGGRYLEAQMGYSTREHAQSGMLVVLAAGDPKLFKECETCFHAAVHTAYWVGSEAGPAAQLGLACSAVSGAVCAAVGECLALADRMAVKRKDLLDIAAVAGFKCALVEDKFLQPRQFLSGPSVSIRNQQKHLHLALSLAQSVSHPTHVLATANEMYKQARSQGYDRRDASAVYLATKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V744</accession>
    <name>A0AAV6V744_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_017944</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAFNEN010000139">
        <property type="protein sequence ID" value="KAG8192409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V744"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904154">
        <property type="term" value="P:positive regulation of retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000015">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF6">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8192409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="710" mass="80231" checksum="4CDEC8BAA2C0A01F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6V8N8</accession>
    <name>A0AAV6V8N8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_005391</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000145">
        <property type="protein sequence ID" value="KAG8192093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6V8N8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16450">
        <property type="entry name" value="mRING-C3HGC3_RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056527">
        <property type="entry name" value="WD40_RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23419">
        <property type="entry name" value="WD40_RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 17" id="KW-0853">WD repeat</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="152"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="348"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="120"/>
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            <end position="66"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8193620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="154" mass="17381" checksum="3D49AE4C150A9CC0" modified="2024-11-27" version="1">MKFIQHRRLGQRHYTPNERTSDTINLIYATFRSFLSSRDANISHSDSPHNCPLLPGPNEPENGPDTDRWKRRAARTTGLCPCPARQKDVCVKCRNVLWSGAFFLELVGVLGVTKGGVYYVANGRMMYGNEEVALWCLSWSILFFEAVEELGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VAF4</accession>
    <name>A0AAV6VAF4_9ARAC</name>
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                <person name="De Corte Z."/>
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                <person name="Vangestel C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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            <end position="1268"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VDU0</accession>
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            <taxon>Araneomorphae</taxon>
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            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
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            <authorList>
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                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="850" mass="95141" checksum="08E086D72D163228" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VGL9</accession>
    <name>A0AAV6VGL9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000091">
        <property type="protein sequence ID" value="KAG8195238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VGL9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="117" mass="13031" checksum="A32A66330EA8F62A" modified="2024-11-27" version="1">MIGVSIGIRCPAGRWLVWRKLKFFTDAQKLFFKGDLFFEFGKSSTREDQRSSPIFPPTISGNRMKEPSSTNLSCVTGKKQRQPEKPPSLSKNLQAPLPPSSIKPIGARQMPGKVPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHK6</accession>
    <name>A0AAV6VHK6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_017915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000083">
        <property type="protein sequence ID" value="KAG8195621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHK6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8195621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="129" mass="14764" checksum="E03C247BEE6DE18B" modified="2024-11-27" version="1">MIKLKTKFNTKHASTKQCKSKRHKQPPSDLPEGSITGAEKKASAHKHSSSRMEGRTPSWNGVWRVGILVWNTGLHGRGEDLSPASLQDGCGEDGEREEQRREEMTMVLRGWGMYDVRHRGYRIHPLRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VHN4</accession>
    <name>A0AAV6VHN4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000073">
        <property type="protein sequence ID" value="KAG8196272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VHN4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="98" mass="10952" checksum="4AC209DD1F828F5E" modified="2024-11-27" version="1">MNMTKYRETLSFECIHPTPSFTIFFSRRVSLALVPKATNDGSDDSDEEPGTASTAVSVVMIDDEMKIATRTQMEPVRLFVSQQSALPLLEIYCLLLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VII1</accession>
    <name>A0AAV6VII1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000068">
        <property type="protein sequence ID" value="KAG8196544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VII1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043876903" evidence="1">
        <location>
            <begin position="25"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="373" mass="41061" checksum="3968F24601CEBF25" modified="2024-11-27" version="1">MNIWSRRFACLLVTAVLLGTLCTSEQEGLLQSLPADILASLTEGDLLAATGGSKNGGSFLDSMSGMGKDTDIGAAMKMMQSVMTKQTQPSKPFVHDSMPSMKKGMHGGMMPIPVPLPKKMLKALPLKKKMALKATAGAIKTAAGAKLMAPKFAAGATLMAPKFKKVAALKAKPKVYSLKPIVHIVEKPVPVFHKVPYPKKVMVPKFYKVMKPIPFPKIVPVPFKVPVKKIIPKIVKIPKFIPVPKFYPVKKPIPIGIPYPVPKFYKVPIPKPVPYKKYIPIPIPKKVPKFIPVPIKKIIKVPKPFYVPIKVPHFTASYMKTPMVVKVPDIKKPPLGFPHGMKGFDHLDFIAGDDKPVFKLKDVDSDDKIHDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VJB8</accession>
    <name>A0AAV6VJB8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000065">
        <property type="protein sequence ID" value="KAG8196699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VJB8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21296" checksum="7C5AC3D70F69D537" modified="2024-11-27" version="1">MLRQLLRIPHTVISQASSIRKISATKLLQHNYEGDGKTTVTLLNRDHKHLIMVNSLSPHGFRLNNGIFAVGPMAVFPRTILQWNIKSVEDITPESLSLFLLLEPKIDILVIGTGNKGETVNPDVLKMLKARKVSTEVLGTEQACSIFNFLNVEGRCVAGAFIPPLDVTLYEEEDFHLIDFKKEDQGPYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VKS5</accession>
    <name>A0AAV6VKS5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_006565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000066">
        <property type="protein sequence ID" value="KAG8196655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VKS5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043451065" description="Chitin-binding type-2 domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="28"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="86"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8196655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="262" mass="30332" checksum="77BED9501591974C" modified="2024-11-27" version="1">MILRFNLLISLLGLLIAIHAVNAAKMDMKKCPKRNGLFPKPGSMCKSYYQCQNFVPFEWKCPKNKHFNTLINKCDWMDNFHCFEKPKVCTEANGKFLKPGTSCKYFYDCCNGKPTEKKCPSEKIFDPFKKKCEWQELSICEEDTSTDNTKTTSPTTEEIKYSTITESDESSSQETTKESDESSSQETTKVSDESSSQETSTESDESHSKEIEYSTTKVSHETSSDEVKYSTTKELQRITLKKSLLYRWNLKKHPREINFYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLB3</accession>
    <name>A0AAV6VLB3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">snRNA-activating protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_023201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000065">
        <property type="protein sequence ID" value="KAG8196689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLB3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019188">
        <property type="entry name" value="SNAPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131">
        <property type="entry name" value="SMALL NUCLEAR RNA ACTIVATING COMPLEX, POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131:SF3">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09808">
        <property type="entry name" value="SNAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8196689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="50263" checksum="A7214E4B3D961B4E" modified="2024-11-27" version="1">MSQVKYIAAGFQEDSEDLLNEFLKENSTNFTVFCTKWTERNFSLIFAGCETEELQQFTEEIFQITLGYFQHHSIIFQIGAVFLLYALYQNQKADPPVKIRITLPQWEVVRKLKALAEKNCYMHMHYIINFLYTNAFEFVYGSKYGPICSKGKAEMERPQNIPPFSLEDCKKEMRSFRNSNRLEEIAALTKEYLQCGEKYKTAFFEHEKRHLDVSKFSNFIKDLDNLLDTEPGKAKKEQRSKKPSDAKLGNRRAEIKANQFSRKARFRQLNASDSDDVDNDVDVDAIIEEQGTSSTRMRRPRRKKRVPKEQRRVGRPRKIKVEKVETDESDHGKAEKVKLKRGPKPRGLAQSYVSAYELKVPTVNKIVKDFLPDDSSETSEEDTNVQKDTNVQEDTNVQDKNVQEDMNVQEDTNVEDKEKDAKEDEELDIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VLK4</accession>
    <name>A0AAV6VLK4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_009053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zyxin/ajuba family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000070">
        <property type="protein sequence ID" value="KAG8196421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VLK4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09352">
        <property type="entry name" value="LIM1_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09355">
        <property type="entry name" value="LIM2_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09438">
        <property type="entry name" value="LIM3_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000028">
        <property type="entry name" value="LIM domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000036">
        <property type="entry name" value="LIM domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000037">
        <property type="entry name" value="LIM domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047172">
        <property type="entry name" value="Ajuba-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047245">
        <property type="entry name" value="Ajuba-like_LIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047247">
        <property type="entry name" value="Ajuba-like_LIM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047248">
        <property type="entry name" value="Ajuba-like_LIM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219:SF4">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="940"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="1005"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="1068"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="494"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="590"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="678"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="777"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="859"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="590"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="678"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="694"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="777"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8196421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1149" mass="125289" checksum="CDB91EB836154B4A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VM13</accession>
    <name>A0AAV6VM13_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_014147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000067">
        <property type="protein sequence ID" value="KAG8196586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VM13"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8196586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="233" mass="26699" checksum="924432EC318F9AB5" modified="2024-11-27" version="1">MTNHHLSKYLGNGKCSLMFLHPSPFLSSSGFPLPAEVSHSMSCFQFTRTLIIVKLEIDVKLASQERKPINVNIKNQSERETSYSKYHIHFPPSGPTKQLIENETVLFLKLLARIRTPHLTLFGWQQAGRFTSPQQQCHDNNGRDGFTTLESLYHKPKKKTSYSKYHIHFPPSGPTKQLIENETVLFLKLLARIRTPHLALFGWQQVVRFNNNATTTMAKLDLQRDCGRTHGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VMT3</accession>
    <name>A0AAV6VMT3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_029386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000046">
        <property type="protein sequence ID" value="KAG8197992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VMT3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007914">
        <property type="entry name" value="UPF0193"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28348">
        <property type="entry name" value="UPF0193 PROTEIN EVG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28348:SF1">
        <property type="entry name" value="UPF0193 PROTEIN EVG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05250">
        <property type="entry name" value="UPF0193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8197992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="206" mass="24243" checksum="8EEEF7E6AC188BB4" modified="2024-11-27" version="1">MNITRNFNTTKFERSKKPPKNNINVLQSLMKEVNLNCKLQDEILNFAESGQSLPYIPKNLIKTENVEKAHLKKVLKLPPRPMQRMKSKIESTGSYEREPYRPDYSKTRPSKEKERLQNMMAFGKDLDEDLLKQKLQSKDVAPEIDSSNLITEILTEIKEREDFLEEMSQLGLREKYLPEIECQISLRLKELEKLNKMKRTEGKQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VP20</accession>
    <name>A0AAV6VP20_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000040">
        <property type="protein sequence ID" value="KAG8198435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VP20"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="211" mass="19373" checksum="8E884FB222B5381F" modified="2024-11-27" version="1">MYGLGGLGGGIGFTGGFVPMMGGRGIGVMGGQGIGGQGLGYLGGRGIGGQGIGYLGGRGQGIGYLGGRGIGGQGLGYLGGRGIGGQGLGYLGGGGIGGQGLGYLGGRGIGGQGIGYLGAGGIGGQGIRYLGGGGIGGQGVGFSGGRGIGGQGLGYLGGRGIGMMGGRGLGYMGGYGMMGGGYGSMIGGMGYGGGIYGPMIGGQGYGGYMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPE6</accession>
    <name>A0AAV6VPE6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_020311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000047">
        <property type="protein sequence ID" value="KAG8197933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPE6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039629">
        <property type="entry name" value="R3HDM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019:SF2">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="2">
        <location>
            <begin position="178"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8197933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="264" mass="30633" checksum="281C0396AF92095E" modified="2024-11-27" version="1">MGVIKKSNIGNNTTDSIEDVLDDIESVGSEPEPEPIRPRRLRTRTTSRHPAIDDIRITAKSGKRKKRVDNSNFLLSLAEEDETQELTIIDFIPPTVSVFSQLFLHRDNIEIWHEFLNCTKNNEDWFQKNIKVESDESEHTGQESYDGRADHPAFTASKCFQKIDGDLRFMLKKKHVPLGTLTYLEQELVTFFGNRPQSIYHCQFPNSYDRLMIHALSQYMDLSSLSYNRSGARWTRVKNKLPDFFTPPILLSSFLEKRYNNKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPS5</accession>
    <name>A0AAV6VPS5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_001887</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000045">
        <property type="protein sequence ID" value="KAG8198053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPS5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043563386" evidence="4">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8198053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="311" mass="33716" checksum="6AF4FFAD78A1DCDF" modified="2024-11-27" version="1">MGLFWALTLAVAVGVVLADDGCPSPASISPCTCDREGINCRDTKSLQEVRKAFQANFKYGGIRAVYIQGTPLTSVPSDLFGKIKAQQFYLEINQITSVDMRAFSASNKTLLVFSLFGNKLQNFAFEEISKFQSLGTLNLGGNLLTTVPSGVLNSRSLYKVILSQNKISSIGMNAFSNLPNLGELELESNALTTLGPMTLAMKSHSAGLQIKLSNNPISEVSPSAFNGTDPLAVFFTRNNLKELKWLPFGGLITGIANKGGFMELSGNPFTCRGCDYSWLVLNKQTIYNFMPGFRCTDGRNLLDITNANIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VPV2</accession>
    <name>A0AAV6VPV2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaoptin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_007139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000035">
        <property type="protein sequence ID" value="KAG8198837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VPV2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043496212" description="Chaoptin" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8198837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1256" mass="142045" checksum="1CC279FDD69B46D7" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VQI6</accession>
    <name>A0AAV6VQI6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_007085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000035">
        <property type="protein sequence ID" value="KAG8198775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VQI6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8198775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="164" mass="19011" checksum="7C6C23096B74BC1B" modified="2024-11-27" version="1">MDVLANHDEDLKQMDIELCNLYFKAIYNLLDMDDQRNIDGFTRYLELLRTETNANCEFYENSKDQDDSLRDLFFDNLFYRIAYVYRNSTLYSSAVAFQFQNVLHHNPKLLKRLIHKQTIHLCSIGCGPASDVVALIKVLESACRRRGVSPDFRITVVDAIMASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS01</accession>
    <name>A0AAV6VS01_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_009332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VS01"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8199484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="242" mass="27558" checksum="77B7CA8F86039C6B" modified="2024-11-27" version="1">MEDINHPDWVPSIKLGYGKTSDSKYIRFLKNKVLKHTKTKLVQLQSFVAKSTNDDVDNIDVSITDSTHDINGYLFKNDTDGDYTNGSQWNNSIVNVPDDHQYTLHRYSDINDSQRQECSNDKVPLDKVPSDNVDNKLPFGKVPSDNVDNKLPFDNVNDKVPSGCVDDLGDCNLSSSFLNNLTKFQQTSSVSVHVQTDLKTTDLDYLNKYCEDTRKKLTEANKKIKLLNTILNLKQRELKTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VS92</accession>
    <name>A0AAV6VS92_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_009393</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VS92"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007276">
        <property type="term" value="P:gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="56"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8199552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="423" mass="47359" checksum="C06047B9242CD358" modified="2024-11-27" version="1">MSSRPRTTSIAESSKQSSQPSFPGIKTTSKDGSKVITVVATPGVVVAPERSQEISYTDTKVIGNGSFGVVYQARLFETGELIAIKKVLQDKRFKNRELQIMRRLDHCNIVKLKYFFYSSGDKKDEVYLNLVLEFIPETVYRVARQYSKSKQTIPTSFIKLYMYQLFRSLAYIHSHGICHRDIKPQNLLLDPETGVLKLCDFGSAKHLINGEPNVSYICSRYYRAPELIFGATDYTTMIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTKEQIREMNRNYTEFRFPQIKAHPWSKVFRARTPPEAVDLVSKLLEYTPSVRCTPLQACAHPFFDELREPGTRLPNSRDLPPLFNFTEHELKIQPSLNSILMPLHIRNSSQNNSVDASMAAESALSSVSLSASSSTVNVASTSTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VT81</accession>
    <name>A0AAV6VT81_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylethanolamine-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_018916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000019">
        <property type="protein sequence ID" value="KAG8200127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VT81"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006126">
        <property type="entry name" value="Staph/Strept_toxin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00277">
        <property type="entry name" value="STAPH_STREP_TOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21079" checksum="197D55066C8072CA" modified="2024-11-27" version="1">MASEGGGFSAESEIVPDVISKAPRYKVEVKYGGLTVDQGNELTPTQVKDIPTSVDWPTEEDGLYTLCMTDPDAPCRKTPKYREWHHWLVVNIPKNRISEGTVMSEYVGSGPPQGTGLHRYVFLVYKQPGVINCSEKKLTNRSGNHRGNFKIESFAKKYNLGDPIAGNYYVAQWDDYVPLLYEQLAAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VU76</accession>
    <name>A0AAV6VU76_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_009461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000026">
        <property type="protein sequence ID" value="KAG8199626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VU76"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8199626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="94" mass="10812" checksum="17C22E47F0FED720" modified="2024-11-27" version="1">MARRLELALHQPRFKNEASFKTSGLAIHFQNPSKFLTSLSPHVVPQHSKKEHYLIPHAPQQNHLSQRTDLFTKQKKVAILSSRILDFGKSYGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VVN7</accession>
    <name>A0AAV6VVN7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_021474</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000010">
        <property type="protein sequence ID" value="KAG8201012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VVN7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000376">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="34"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="136"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="231"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="326"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8201012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="428" mass="48341" checksum="93DC2AC7AA48BD17" modified="2024-11-27" version="1">MILDGKVKQFGLLFVLFGAFGNVVGNHQIVGTDPVFAEPIPNTTVTAGRNVSLPCIVDNLQNYRVAWIHTNKYTLLTLQNRVITRSSRYKVSHSSHRTWWLHISNVQERDRGEYMCQINTIPMMTQTGYLEVVVPPYLNEELTSSDMDVREGSDVSLRCMAKGSPEPEVTWRREDGQEISVGKSKVTSLKGSFLNITKVSRLHMGAYLCIASNGVAPALSKRILLGVSFTPMIWIPNQLVGAPVATDILLQCNLESHPRSVTYWIREGGIMVLTNLKYKTEVQPTVLYKVQLKLYIYNLEPEDYGSYTCVAKNSLGETEGTIRLYEIPPPTSNVNEKGDDIFNSKSEKLRNGHQKNSYKKHEEKDYSPHDPADQNSKFQPREEFSQILKSKGEHATSMCSATFQIQSLSSMMSLVLIYLYWKNISNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VW72</accession>
    <name>A0AAV6VW72_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">LDLR chaperone boca</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_006403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MESD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000013">
        <property type="protein sequence ID" value="KAG8200824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VW72"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000031">
        <property type="entry name" value="LDLR chaperone MESD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019330">
        <property type="entry name" value="MESD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17600:SF2">
        <property type="entry name" value="LRP CHAPERONE MESD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17600">
        <property type="entry name" value="MESODERM DEVELOPMENT CANDIDATE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10185">
        <property type="entry name" value="Mesd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043888154" description="LDLR chaperone boca" evidence="8">
        <location>
            <begin position="23"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8200824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="22452" checksum="78954DD5D053FE01" modified="2024-11-27" version="1">MWNLNRFIICIFLLSFVIDIHCKNPDKKEKPDWAKKDIRDFTEADLERLYDQWEEDEDPLEPDELPEHLRPPPKVDFSNIQGSNPESLLKMSKKGRTLMAFVTVSDNPTEEETEKITTIWQSSLMNNHINVDRYPIGPDRVILMFKDGSQAWEAKDFLVEQERLEVVTIENKEYYGKYSKKAKKNDKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VX51</accession>
    <name>A0AAV6VX51_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homologous-pairing protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_028565</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000016">
        <property type="protein sequence ID" value="KAG8200387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VX51"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="9">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="10">
        <location>
            <begin position="151"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="81"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8200387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="210" mass="24015" checksum="A31835A8A022BFDE" modified="2024-11-27" version="1">MSKSGNSNPSQLILTYLKDQNRPYSAIDIFNNLHKEHGKTAVVKALDLLVSESKVKEKTYGKQKIYFIDQNEFATSENTNLASMDAEINNMTHTLTEFQKQIKNSESVLGNLDKSLTTEAAMAELNALNKEIPQLKEKLHSLESNKSQVGPKEKEALYKAKMKYCKEWQKRKRLANDMIDAILEGYPKDKKHLYEEVGFETDGELKVFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VXS6</accession>
    <name>A0AAV6VXS6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_020525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000011">
        <property type="protein sequence ID" value="KAG8200885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VXS6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8200885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="91" mass="10344" checksum="0D62B4FD94F2E25B" modified="2024-11-27" version="1">MYLLNDIPRCSSVCKGFFSNKFDTSVCPACGLEEARKCVPSIFIDLGSKYFLLDWGKKKPDVPLGWNAERFYHKGVAFSSKVVGIYFVFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VY93</accession>
    <name>A0AAV6VY93_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-Maf-inducing protein PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_011258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000004">
        <property type="protein sequence ID" value="KAG8201592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VY93"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052813">
        <property type="entry name" value="CMIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056429">
        <property type="entry name" value="PH_CMIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25480:SF0">
        <property type="entry name" value="C-MAF-INDUCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25480">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23066">
        <property type="entry name" value="PH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-Maf-inducing protein PH" evidence="2">
        <location>
            <begin position="128"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8201592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="763" mass="86136" checksum="0D9D215601EAE8FC" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZ23</accession>
    <name>A0AAV6VZ23_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_016786</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="EMBL" id="JAFNEN010000006">
        <property type="protein sequence ID" value="KAG8201305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZ23"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17059">
        <property type="entry name" value="Ubl_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="10">
        <location>
            <begin position="122"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8201305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="323" mass="36532" checksum="0A7480A6F469942C" modified="2024-11-27" version="1">MASNTMLIKCKTENGSFTLKEMTPDNTVMDMKKCLQQYSNISPDEMRILCGYPPKPIREEEHDLKLCEVKIFSGDTIIVETIKRPVQEIKDKKSSEHVMGNKLGEANRQEYNLMEVEQGGIMMRHVVPSDNSCLFNSVYFALNDGEYDGQISNNMRQIIATAVQNNPDKYNSAFLGKENLEYCAWILDSNHWGGAIELSILSEHYKVQIAAVDTVSLSMHCFGEDGNYTQRIFLIYDGIHYDPLLLELGNTRQTVFGVDDRKVKEMVMELAKEAKSSRQFTDVANFIVSCLECNTKLHGEKQAMEHAKSTGHVSFGENEAVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6VZ83</accession>
    <name>A0AAV6VZ83_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein on Y chromosome</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_027460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000002">
        <property type="protein sequence ID" value="KAG8201989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6VZ83"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051242">
        <property type="entry name" value="WD-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324:SF6">
        <property type="entry name" value="EF-HAND CALCIUM BINDING DOMAIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="280"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="722"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8201989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="942" mass="107321" checksum="0C6BBA19BFA841D1" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TD92</accession>
    <name>A0AAV6TD92_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_023262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006478">
        <property type="protein sequence ID" value="KAG8155906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TD92"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8155906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="60" mass="7187" checksum="EEAE8BA01F39612A" modified="2024-11-27" version="1" fragment="single">IIKGNRLACSERAVTAVRRTARLELRSNYELFNRNNFNIRYWSKCYRGCWHLACPPIDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TE65</accession>
    <name>A0AAV6TE65_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006148">
        <property type="protein sequence ID" value="KAG8156234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TE65"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8156234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="99" mass="11069" checksum="9CCBCBB96FFE7A3A" modified="2024-11-27" version="1" fragment="single">VRYWESDQDMTSAKEVERYLDGNDLEVVVSGLTLGKEYKLRVLAFSNGGDGKMSSPVREFTIGKASALYRTSSASSFHNFLVPMHLWTIIFIACKLSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TER6</accession>
    <name>A0AAV6TER6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_022097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010006028">
        <property type="protein sequence ID" value="KAG8156629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TER6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8156629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="303" mass="32175" checksum="EC18C8BF9C0AFD10" modified="2024-11-27" version="1">MVRLVLRPRPRSDDDLHVKTPLRTSTRVFPLASSCPGIVHHLSGPNVCAQTPPLPQVERGGSPVRPAREGTGIPNAAALRRPVTFISPRAYSRPIDSRPILDPFGSVFQDGSGVSLPSNPLQGDRIRIEPSSYGPRTHFGQQPRSRGLAAESVPARSLLNATFPHALASGGFGAGLLPVHSPLLRASLSVSFPPLISMLKFSGLSRMICGRHRGADNCNRPTPSPKGVFKGFYPFLWKGGKSTRVSLSMGARCGPGHLRALQTCYALPPVRLNAPSPSKGKNAGQGKDPSVPLVGPEPPAVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TET8</accession>
    <name>A0AAV6TET8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005782">
        <property type="protein sequence ID" value="KAG8161376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TET8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8161376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8682" checksum="C9FD564BA8D7D9F1" modified="2024-11-27" version="1">MRNRSQGNGLGKISGKEDPVELTLVEFVKRHERVDKWEGLHVSEIPCFIRSLLPVNSPRKATRKDHASSPKRDCLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFB8</accession>
    <name>A0AAV6TFB8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_020211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005342">
        <property type="protein sequence ID" value="KAG8170498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFB8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8170498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="69" mass="7572" checksum="1F0F864B0E4D3DAD" modified="2024-11-27" version="1">MGQSVLRDRRNPFRSETSAETQTHARVCLAADRKEWVNIPQPGKRNRSFGTKCGNATELGDVDGGPGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TFC6</accession>
    <name>A0AAV6TFC6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_016398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010005329">
        <property type="protein sequence ID" value="KAG8170504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TFC6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="125" mass="14320" checksum="5945EC6A67FCD5B2" modified="2024-11-27" version="1">MAVANARLPPPLLLGAAGTNCSKQWKDWLQQFEWYALVAELDKKAANVQVVIFMSAIGQDAINVFNTFPEDKRVDLKLLITEFNNYFTPKVNITYERFVFNQVIQVAGQKFDDFYTEVAEQKPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TG83</accession>
    <name>A0AAV6TG83_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_008085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004793">
        <property type="protein sequence ID" value="KAG8170835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TG83"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8170835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="146" mass="15860" checksum="653500332E122AAD" modified="2024-11-27" version="1" fragment="single">ENSVPISGRADSRDTNSYKEKILFPGSSVDVSEFGCVTALGPEGPISVSGLGNINPIPFRSQRDKHEHVFAFRQTSRFGTDFSDPLGPTDPCSTAVHMEPFSSFSPQGSHLSICYYHQDLHRWRLQAGSRPAPSTHATATLLLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TI27</accession>
    <name>A0AAV6TI27_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_011158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010004104">
        <property type="protein sequence ID" value="KAG8171355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TI27"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8171355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="92" mass="10306" checksum="2F0F8E5B204385AE" modified="2024-11-27" version="1">MGHRSWVGEIPFSQAGTFCRKAKTLSRGFVSPGPPKGNGVNIPQTPEPRNRAPREPKCGKPKPNWRKSTEDPGKSYLFFVRFPVSPESVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TIW7</accession>
    <name>A0AAV6TIW7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_014267</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003747">
        <property type="protein sequence ID" value="KAG8171621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TIW7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="86"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8171621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="307" mass="35060" checksum="8CB91EB6E08B16F4" modified="2024-11-27" version="1">MRMSIPPKEMLAITLRYLASGCSLTDLFFTYRIGVSTASIIVQTTTERIWQCLAKLHFPEATQENWLNIAANFKRSANFPLCLGAIDGKHVRIQNFPNEGSMNFNYKKYHSMVLLAVADSDYKFSFVDVGGYGKDCDSNILKQTELWDLLIRKQLNIPNPAPLPPHNLKVPYVFVADEAFPMQENAMRPFGGHNLTVKQRIFNYRLSRARRFVECAFGILTNKWRIFHKPLIMSRRKAMAVIKCCTLLHNIVREMDGYRPDDLVTCTLDAVTSSTTTMMKTPRGIRTVFANCFVSEIGALPWQMSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJJ3</accession>
    <name>A0AAV6TJJ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_010129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003219">
        <property type="protein sequence ID" value="KAG8172039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJJ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="108" mass="12459" checksum="DA116C341CF16291" modified="2024-11-27" version="1">MSIQSKKTNDCDKSHKNNFFPVINETGGIFWLLELKREKRSTKVRTQPPRLENVSNGSQCLENNTSRIKGCSYSCDGDSRSLEERQIYPEKKEAPSLQEYLDICVKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJK2</accession>
    <name>A0AAV6TJK2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_022072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003452">
        <property type="protein sequence ID" value="KAG8171868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJK2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8171868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="81" mass="9047" checksum="E00F0E32C3B864A0" modified="2024-11-27" version="1">MKVQAAEVGRIRDPRFPLGRAPPWRPARFQLCGSGGVLERYNTRWDPKDGELMPGRTRPEETLVEVLVAGSDVANRSSSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJN8</accession>
    <name>A0AAV6TJN8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_028623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010003196">
        <property type="protein sequence ID" value="KAG8172054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJN8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044784">
        <property type="entry name" value="At1g01640-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47274">
        <property type="entry name" value="BTB/POZ DOMAIN CONTAINING PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47274:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="13164" checksum="AADD6032837A5620" modified="2024-11-27" version="1">MELMLDFLHSEILEEDLSTEDICKLYFAADKYQISHFKQKCTRLLLSRLSVAEVCKVLILADLHQDDFLMSCVHNFVKYHANEIFHSSQWEELSNENPILSGRIMLQVWKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TJW1</accession>
    <name>A0AAV6TJW1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1</fullName>
            <ecNumber evidence="6">2.4.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Core 1 O-glycan T-synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Core 1 beta1,3-galactosyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">JTE90_019619</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="6"/>
    <dbReference type="EMBL" id="JAFNEN010003298">
        <property type="protein sequence ID" value="KAG8171988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TJW1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000017">
        <property type="entry name" value="Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="23">
        <location>
            <begin position="79"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00059245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAG8171988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="327" mass="37433" checksum="9EFC97162A57E296" modified="2024-11-27" version="1">MAALSRNCILTLVVGMACGFCFAYVLFSMTNWSPWNVVPCDGCIEFFGNGTVEGDAELANELSQRIRVLCWVMTHPAARKRCESIKRTWGKRCNILLFMSSEEDPDLPTVRLDIEEGRLFLWGKTKQAFKYVYEHYLDKADWFMKADDDTYVVVDNLRYMLQAHSPDRPVYFGRKFTKYVEKGYMSGGSGYVLSREALKRFVEVSLPDPDKCQQNNGGDEDLEMGECLGNADVFPGSTSDCHGQGRFFPLELESHLEPGGLKPNNWFWKWADSPSFEREKDCCSDTAISFHYVAPETMDVYESFIHRFRPYGIKTHLTKAITPDAYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKA1</accession>
    <name>A0AAV6TKA1_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_021268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002761">
        <property type="protein sequence ID" value="KAG8172395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="849"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="1288" mass="138989" checksum="3517FE7907C76861" modified="2024-11-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKP0</accession>
    <name>A0AAV6TKP0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-oxoacid dehydrogenase acyltransferase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002629">
        <property type="protein sequence ID" value="KAG8172530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKP0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-oxoacid dehydrogenase acyltransferase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8172530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="177" mass="19091" checksum="127E41D6C9EB57E7" modified="2024-11-27" version="1" fragment="single">VIARRLVQSKQTIPHYYLSVDITMDRILRLRSELNEMLSKDGVKLSVNDLFVKAAALACKKVPEVNSSWMDTFIRQYHTVDVSVAVSTDAGLITPIVFNADSKGLSAISSDTKTLAGKARAGKLRPEEFQGGTFTISNLGMFGIKNFTAVINPPQSCILAVGGTENAIVPDSSTDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TKY2</accession>
    <name>A0AAV6TKY2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_011586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010002897">
        <property type="protein sequence ID" value="KAG8172278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TKY2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8172278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="123" mass="13331" checksum="7AE17C17302D0E24" modified="2024-11-27" version="1">MSSPVGTESSEVFSPAIDHDMFPRSGVAAPPLSNVNRVALPQRCLPGKPTSAFRKPVSPGPRSFFADGHVPSPREICTYMMHCKTALNLNIDIVQDQLEILDTLGPNETASKIFAYFCNVGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TNF9</accession>
    <name>A0AAV6TNF9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_002013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001788">
        <property type="protein sequence ID" value="KAG8173419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TNF9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000003">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="6">
        <location>
            <begin position="499"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8173419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="783" mass="89046" checksum="7191EBBAE54A3CCA" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TP31</accession>
    <name>A0AAV6TP31_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_012219</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010001563">
        <property type="protein sequence ID" value="KAG8173659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TP31"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF12">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8173659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="490" mass="55810" checksum="761BC6C3844DA75D" modified="2024-11-27" version="1" fragment="single">ILYADIVNSMLLAASLKVSDLVATLNDLFGRFDDSAERNKCMRIKLLGDCYYCVSGILSDSNRHADNCVATGLDMINIIRRVREERGVAVDMRIGVHSGAIFGGLLGLRKWQFDIWSRDVTIASHMEQAGVPGKVHITRATKDHLQENSYDILPGDGHLRDAYLRAEGIETYLITPKYVSGPRIYRHESRDSTDGRFQRQIQLQNHSKHNITRLNKRQSSNDNVLPMSRRGAIGFSLHQYRKLVSEVNKIIENTIDKMALSKKDQWCSRSVGIHPLFLTFREPGREWAYLAQPDPLFKHYLLCVLLIFSAITAIHLLIMSRTVLFWVTYSIVLLLILITSIVAWVGYIWSYFTNDDNDNLKNSRALKISRKVWKTTSLRIALWLAISSMVLFSSIIGLNECLDSGFFQPRFNSSLPNGNYQISSNTSLSCAFPWFYTMCASLAMTTTSVFLRIHFLLKLALNSVALAVFWYTIDVRGEEVFRQQTAQLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TPX9</accession>
    <name>A0AAV6TPX9_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_004911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001444">
        <property type="protein sequence ID" value="KAG8173887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TPX9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8173887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="173" mass="19382" checksum="7EB5E20128E4C938" modified="2024-11-27" version="1">MPRQLNVSPLRRKQGGGVFVGPRRVAAFPGLFGSGSLAEMAARVAQHPKLRANEVPPHDCPYFCPYCKHCAKIKHLLNNDLVDLPLGPEAYYDKLRKMAAKEEKQRREEVRRREEERRREEEEEEELPAEVGRDASGDLGAVVVAAQDLLDDGAAPEIINQVPDITPPPQEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TSJ2</accession>
    <name>A0AAV6TSJ2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_020607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001118">
        <property type="protein sequence ID" value="KAG8174877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TSJ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="65"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8174877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="274" mass="31569" checksum="598855F67029014D" modified="2024-11-27" version="1">MDSEEYSDSDSSVSDVFTDTDSDSDDSLDAARVWCKVDSDNLSPPPPKFPFTGTPGLKEQMYGSSPLEFFSIFMPDDIVSYIATETNRYAEDFIEKTDLTPSSRAQQWKEVGSSELRVFFAIILLQGIIRKPLQKWYWSQNPLISTPYLSSMMSEKRFSTIMRFLHFTNNNTLDLSTHPQPGLRKIYEVYEAINQKFKSAYVPEKDISVDESLMLFKGRLGFKQYLPKKRARFGIKFYQLCESSSGYIWNSIIYTGKDVPYGVRQQPIELQQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TT60</accession>
    <name>A0AAV6TT60_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_017434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001132">
        <property type="protein sequence ID" value="KAG8174839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TT60"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043966934" evidence="2">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8174839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="106" mass="11963" checksum="E2CC486EAB76314A" modified="2024-11-27" version="1">MASSFTIFVLLCLVSFTLALSVPTDGSTKDVLHYQPASRDVKIRVKRQRNRNRNRNRGPQSTIQGVSQPFCDKFGCNNRRQPNRRQCGNGFIFDSRSGGCRRVRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TTM2</accession>
    <name>A0AAV6TTM2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_026253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001022">
        <property type="protein sequence ID" value="KAG8175365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TTM2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="7670" checksum="58E5C4C2F207FDBF" modified="2024-11-27" version="1">MCNESPMHVSMATQPHWFPILATPNILTIVEECDCVCSDEGLCCCYGDASPPPPAHFEEFDGVDDILAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUA0</accession>
    <name>A0AAV6TUA0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phlebovirus glycoprotein G2 fusion domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_011657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001093">
        <property type="protein sequence ID" value="KAG8175021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUA0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.98.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009878">
        <property type="entry name" value="Phlebovirus_G2_fusion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07245">
        <property type="entry name" value="Phlebovirus_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043338897" description="Phlebovirus glycoprotein G2 fusion domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Phlebovirus glycoprotein G2 fusion" evidence="3">
        <location>
            <begin position="389"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8175021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="830" mass="92861" checksum="2518E8D3214951D9" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TUI6</accession>
    <name>A0AAV6TUI6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010001042">
        <property type="protein sequence ID" value="KAG8175266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TUI6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8175266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="93" mass="10942" checksum="BD657204F402FBA3" modified="2024-11-27" version="1">MPTMRKKFQSVCKSSHFILLLRKKSRKTTWRAEKRMPIKDTSLRTWSTRTTLGTKTELENELGTKTEWHSFFKGLQLSQSDTKPKYNTTKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWE6</accession>
    <name>A0AAV6TWE6_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JTE90_010021</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000897">
        <property type="protein sequence ID" value="KAG8176302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWE6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000078">
        <property type="entry name" value="glutamate receptor ionotropic, NMDA 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF38">
        <property type="entry name" value="IONOTROPIC RECEPTOR 100A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG8176302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="151" mass="17341" checksum="DC047F45065EF1ED" modified="2024-11-27" version="1">MFPKHLNVAFYNYTHIFEFHNDTLGHVTINGVEAQLLKILSRALGFTFNLVTPEDGHWASVRSNGQWNGLIGEIEKGRADMAIGMTWIKEDRQEVADFSVPYYFDDVTFSTRLPDLLPKTHIYVLPFDIPTWVGIVAMWICLPGVFRCLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TWT3</accession>
    <name>A0AAV6TWT3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Density-regulated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JTE90_012956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">W744_W776</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DENR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000915">
        <property type="protein sequence ID" value="KAG8176166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TWT3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000004">
        <property type="entry name" value="density-regulated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="103"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG8176166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="186" mass="21007" checksum="07CCDBF35B6BB06D" modified="2024-11-27" version="1">MAGDVPSDVAVGNALPVGPIKGHIYPLEVIYCGECSMPLEYCEFYPNYEKCKEWLQKNLPDIFEQKMKLDAEPAQGDEEKKRQKRGGKGMMKAKKKSEKEKKICLSRAPRGKKKFVTVITGLKTFDIDLKDAAKFFSHKFSCGSSVTGDDEIVIQGDVKDELFDIITEHWPEIDEDVIDLLADQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYN4</accession>
    <name>A0AAV6TYN4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_003422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000849">
        <property type="protein sequence ID" value="KAG8176794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYN4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8176794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="169" mass="19007" checksum="6179858F5D94989F" modified="2024-11-27" version="1">MFAPSTSKANQHIPGSGSSSPDSRKMSGSRSFSSDSRKMSSGGDNVSQPTNLLYRDELSTELFESPDENSILTNQEIDNIVREWQIYRVDEDIDEFCDGFIKIVDTEKNVVKYERLDSFYWAKVLKLNDKIFGAKKYDILRLIKACLSLSHGNADPERGVSVDKTIVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TYU4</accession>
    <name>A0AAV6TYU4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_026581</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAFNEN010000846">
        <property type="protein sequence ID" value="KAG8176869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TYU4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="250"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="675"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="838"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="864"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8176869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="933" mass="105086" checksum="A7963CD86D9B0088" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZB4</accession>
    <name>A0AAV6TZB4_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_025899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000816">
        <property type="protein sequence ID" value="KAG8177126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZB4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="147" mass="16952" checksum="FE82949BF2A502B1" modified="2024-11-27" version="1">MEGHRLQPDKEFLCHACYVKEKKPQLTTQEPVTQQDQRTLPQPSNCPLSSPSPSRSHSQEETNPTKGNFTTAPSIQPLEDNSSPNTLLEDFWTIQLRSLRYNGKVGVWKGAASCQIRVWYLFRNIFCLQDNCVVYYHRSYGYILDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6TZQ3</accession>
    <name>A0AAV6TZQ3_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_019649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000767">
        <property type="protein sequence ID" value="KAG8177622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6TZQ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8177622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="356" mass="39224" checksum="AAD2CC742706151E" modified="2024-11-27" version="1">MGMRNVLVGEFIAPILDQFKPPGRSGSMGKVDNMVEVRKKEIEIGKLRATVSAIQSKVTVLEEELAKEREAIRKYLEIGVALSKTVEEIEKVSDNKVANIKKTYESQLTALDLLEKERNNSCNKFLEKLVKGRADEISSTDKILAHYDVNFREQNEKIVSISSEMGEIKEAIKNSLDNLKIDLTNHSMPSSSASPTYADIIGRENNNTTTMFVDLPTDGEGGKDFKGFKNKLESLLTNENVKCNDIFETKKGAKISAPSLTDAHKMRDYLNKNETLLNLKVSIQSVSVVEENTSVKVVADTQVSSPSSSVLEDNTSVSDALDALNFDMCSVGSTIQASPSSQGDEHFLMEEDEGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U0B9</accession>
    <name>A0AAV6U0B9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipase A2</fullName>
            <ecNumber evidence="5">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphatidylcholine 2-acylhydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JTE90_028698</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phospholipase A2 family. Group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000797">
        <property type="protein sequence ID" value="KAG8177243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U0B9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04704">
        <property type="entry name" value="PLA2_bee_venom_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.90.10:FF:000002">
        <property type="entry name" value="Phospholipase A2 group III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043775803" description="Phospholipase A2" evidence="16">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="17">
        <location>
            <begin position="121"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG8177243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="284" mass="32518" checksum="586BC7D622650C64" modified="2024-11-27" version="1">MDLVLKTFLYFHVLVSVVYGSILREKMTVLQDPNDEADRKVVVVSWRNDYGDGFQCQMYTDQKLIQEVLKTSGDEPVRRPTKEEMAFIREECDSFSDMTRRRRQVEDSEGSSEAASSWNVIFPGTKWCGNGDTASNDDDLGSHADTDRCCRAHDKCDDIVLAGETKHNLTNKSPFTKLSCKCDDVFYDCLSEVNSLPSNTVGNTYFNLLRRECFKNDYPLGNKCLKHTSPLKITCLEYERDYSSPPVYQWVSAKIFKNLPVPGPLDIKLRISDEKMDMLRQILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U224</accession>
    <name>A0AAV6U224_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_010883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000729">
        <property type="protein sequence ID" value="KAG8177988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U224"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000001">
        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF360">
        <property type="entry name" value="CHITINASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8177988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="340" mass="37649" checksum="4395C84D51951FF3" modified="2024-11-27" version="1">MSAFPPNLCTHAIYGLAKLEENQIVSGQPLRDLPENLKGYQIFNDLKLRNPNLKTLIGIGGWDMGSAPFSFMASNPEKRSVFIDSVVSFIDKHGFDGIDIDWAYPGSNGGRPVDRQNLELKAALKPRGKLMTATVSATASVIEMAYDIPKISEELDQIHILSFDFYGSWNNYTGMNAPLYAPAEATMEEKEETVDFAVNMWLEGGVPKEKLVLSLPFFGRTYTLADPSKNGVGAAATGAGKPGQLNGNDEELGFNEICENLTKNRWASVWDTDSHTPYAYKENQWVSYDDQKSLNTKVEYLIRKGLAGALVRSIDTDDHKGQCYGKKYVLLRSVASKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U259</accession>
    <name>A0AAV6U259_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_012448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000763">
        <property type="protein sequence ID" value="KAG8177669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U259"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8177669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="252" mass="29438" checksum="D3EB36A6EABBA731" modified="2024-11-27" version="1">METLQDPFRSLLDDLTQDFLKLKTFCLQQEEYSRKIDAAENKRWRQILDRITGKDTLVGSAKPEPYRETLSDSISRKLGLLSTHYYDLWRRYERAQRRIAEQRVKCQHQRQLGLIEHGEADTLIASDETEPTHITNKGKEKTSQPIPIEISAEIDKHLGLKFLQSELDGVPIQRKKKSEPLRDGNRLNRCQHKNSPQSQEKSLEEVEAEEADGKMVIIALLKEIEERDNLIGMLKFQLQVKEKELFYHSQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U2I9</accession>
    <name>A0AAV6U2I9_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_006298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000713">
        <property type="protein sequence ID" value="KAG8178159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U2I9"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8178159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="124" mass="14131" checksum="8EEEB9493ED7B12E" modified="2024-11-27" version="1">MCCIWESETSFVPHVQELSKKISSHRNTAAPKTREGSSSTMEINIIAECFLTSMQTYGVKYHQVIADGDRNVYKTILGANPYDTLTVEKIECKNLLLRNFCNKLKDPTRNAKLKHINLRKEIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U374</accession>
    <name>A0AAV6U374_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_001314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000705">
        <property type="protein sequence ID" value="KAG8178278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U374"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044000633" description="Fibrinogen C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="64"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8178278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="210" mass="23949" checksum="38B8000DF4D16873" modified="2024-11-27" version="1">MLCLNIRKDLWALILGVVLAVNYVCGNVTSTCGNSSKSISYLEIAADMITKVKDNYPICSCANAVNSTRPVDCEEVLRRGQKQSGVYAVWPRSRVIGDRSLEVYCDMDTDGGGWLVLQRRGNFNRSNDYFFKDWVSYKNGFGDIDKDFWLGNDNIFALTNQRLYSIRFDLKAVSGEKRYALYDAFWIDDENNKYTLHIQDYSGDAGNFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4G2</accession>
    <name>A0AAV6U4G2_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_014130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000659">
        <property type="protein sequence ID" value="KAG8178924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4G2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8178924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="642" mass="70817" checksum="03E4554CC1C7D21C" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U4X8</accession>
    <name>A0AAV6U4X8_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_010101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000651">
        <property type="protein sequence ID" value="KAG8179072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U4X8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8179072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="456" mass="52833" checksum="37361C3E8F4970FD" modified="2024-11-27" version="1">MGRKLKKSSKEYKIERIHRNRQEIESDHLKQRSLIFRIFKQSGNDIEKEIDKQETLLATDCSTVTENKILDKPSKLSTMSNVEEQTELKIQSESSNENKDCEWNNIVIKKRKYTKRNRIKICKKDSELRRTSRKIIVRVNKDFIGTNCIKMARKKKCKESVPINLNKPDEVVVKRGRGRPRKPKPIPSPPDISKKTDDGAVWTLVPKEMIDSDYFKSRVLQVHYPQESTKPFSPPPKTLPRLKFPFTPLQNNENFGARTGFLTNGNLNEIPRQFREKQYYNSPSRRPTVVYCKEPKNFSSRLTPYLEELQDNSNRHFKPSGGSMTSKGWQIDYLSRKYNNLIEKSEIEYIFGECGQNLQKTEEFLSDVLSSGNKLLRTDNNGQLSVINNSHNQAPTFQVNENYLSASQKSQTSSNIKSSTTQDLQTPKEFPDTLFRQVIVDSIKLLYDEDSVLGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U6L5</accession>
    <name>A0AAV6U6L5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JTE90_024134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000639">
        <property type="protein sequence ID" value="KAG8179285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15261">
        <property type="entry name" value="THROMBOSPONDIN-TYPE LAMININ G DOMAIN AND EAR REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15261:SF4">
        <property type="entry name" value="THROMBOSPONDIN-TYPE LAMININ G DOMAIN AND EAR REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043742315" description="FHA domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="910"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG8179285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="2041" mass="223705" checksum="36B5873DDBB71781" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U799</accession>
    <name>A0AAV6U799_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="7">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_006277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000597">
        <property type="protein sequence ID" value="KAG8179914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U799"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000116">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000237">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8179914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="289" mass="32273" checksum="17587CF96011E500" modified="2024-11-27" version="1">MELEDRVLDVISNNPTGATNAALQAAHPGSGLAELVEVINKLVSKDKIQIFHKGKQLVYMLKDPESAKKCKGVDVEDKLIYQLIEKAGNKGIWIRDLRYASNIPQAQVNKILKSLESKKLIKSVNSVAASKKKLYMVHGIEPDRSVTGGTWYSDQEFESEFVDVLNQQCHRFLQQARTLAEKQHPDPISRKRAAFKTSQEICGFINGLKVSKVELSVTDVETILETLVFDGKVERSPEDPKSFSVVRPLLSSCGLMRVPCGVCPVHRECREGGVVSPTSCPYMKEWLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U811</accession>
    <name>A0AAV6U811_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_027861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000586">
        <property type="protein sequence ID" value="KAG8180081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U811"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="720"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="888" mass="98898" checksum="2197EE1DC4F4D92F" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9D5</accession>
    <name>A0AAV6U9D5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_005806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000554">
        <property type="protein sequence ID" value="KAG8180709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9D5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="122" mass="13940" checksum="EFC8DF23A2D04E54" modified="2024-11-27" version="1">MEVSAPCSSGKVTPYIDPGKGVTGYAPFRSWTGVQEATWPTCYRRKGISIDFEYKRICWRCPAIRKHQNDIKIKPVIPSSRDSQLPGKMRRNQEKKWDTGSLLSARSMYSPDLSSGIWERID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9D6</accession>
    <name>A0AAV6U9D6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_019547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000571">
        <property type="protein sequence ID" value="KAG8180266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9D6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8180266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8172" checksum="544F2245F9DEE7A7" modified="2024-11-27" version="1">MILSLLAYPTTGEQSISSAATRNKNKKGAKDMEGSLLWLPPEGNLIMDVHPPLLCPPPGDPLVFYRVGCGMGMVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6U9U4</accession>
    <name>A0AAV6U9U4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Intraflagellar transport protein 80 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JTE90_016488</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000575">
        <property type="protein sequence ID" value="KAG8180211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6U9U4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000007">
        <property type="entry name" value="Intraflagellar transport 80 homolog (Chlamydomonas)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000298">
        <property type="entry name" value="Intraflagellar transport 80 homolog (Chlamydomonas)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001115">
        <property type="entry name" value="Intraflagellar transport 80 homolog (Chlamydomonas)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056456">
        <property type="entry name" value="Beta-prop_IFT80_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24098">
        <property type="entry name" value="OUTER SEGMENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24098:SF0">
        <property type="entry name" value="OUTER SEGMENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23335">
        <property type="entry name" value="Beta-prop_IFT80_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="IFT80 second beta-propeller" evidence="7">
        <location>
            <begin position="303"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="8">
        <location>
            <begin position="620"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG8180211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="88019" checksum="75A20F19907FF0FF" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UC97</accession>
    <name>A0AAV6UC97_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_027909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000526">
        <property type="protein sequence ID" value="KAG8181241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UC97"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="76" mass="8705" checksum="A38AFB69AA5F0FED" modified="2024-11-27" version="1">MFPTSVPQEENHVLQKIPQEDLFVLGVDMEDCFLWPEIRSPKPYEIKSPQNQRRALNTVDIAANLGPELQKGISEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UD81</accession>
    <name>A0AAV6UD81_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_017722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000505">
        <property type="protein sequence ID" value="KAG8181601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UD81"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21615">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21615:SF2">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8181601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="188" mass="21658" checksum="F6403C367B801903" modified="2024-11-27" version="1">MNQITLRALTSIQLASKLDSHYNHLLPKQVSDILDRINKSYNKTGIFNSEIRIIRTLKYNMNVTNPSIYVGLLLSVLYNNDPSTDDHLYTASYKVLDLMYLNRAKIYDHLYESITGTSATESPENKNMTKIKADYMLLATAIIAASTYIIMKDKWNNVLEQLHQITRLFRTDIRNFSIAIVHVISVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UFY5</accession>
    <name>A0AAV6UFY5_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_008116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000450">
        <property type="protein sequence ID" value="KAG8182738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UFY5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8182738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="85" mass="9582" checksum="EE5831748CE13543" modified="2024-11-27" version="1">MPSFWSKTSRQGEEGCRQARRPRSAWAVDGISSRSIRDIPDDSHSLRGVFHLAPFAHILARFTTEKISSPDLSRPCVPTHHCHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGJ3</accession>
    <name>A0AAV6UGJ3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_004255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000442">
        <property type="protein sequence ID" value="KAG8182889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGJ3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="208"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="281"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="355"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8182889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="440" mass="50068" checksum="BBC7928092BD9CBF" modified="2024-11-27" version="1">MASNNLPGFMKPPPMSFLSSKMSEKGKLFKLHLRRRHTSGTDDRASRSKERKGALLRRHSIDPDRRRALQAAAGKSTDDHHTSLIHRGVPLQADPLKDKIDIEDLGENENLVYVKFFKCYRCYDLIPVSAKLVIFDTQLLVKKAFFALVHNGVRAAPLWDSNSRSFVGMLTITDFINILRTYYKSPFVQMEELEEHKLETWRNVLKEKSKPLVSIGPDASLLDAIKALIQNKVHRLPVIDPFANNVLYVITHKRILKFLHLYYNELPHPSYLSNTLGELNIGTYSEIATVKTSTPVITALNEFVERRVSALPVVDDNDKVVDIYAKFDVINLAAEKTYNNLDITVKKALEHRSQYFEGVLKCTLDDTFSTVLQRIVKAEVHRLVVVDNEDHVVGMISLSDILNYLVLRHTEEPKPDGSPKKTTEDQLNEEPEESAEAPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UGP0</accession>
    <name>A0AAV6UGP0_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_028749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="JAFNEN010000441">
        <property type="protein sequence ID" value="KAG8182928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UGP0"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG8182928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="438" mass="49867" checksum="7E53995A8A017759" modified="2024-11-27" version="1">MNGLFVKFHLVLLINWSRNSSSITRTVSMLAAAWIAAAAVSCAFAQDTELLLVQMIYRHGARAPIIPYPTDPNPPESWPEGFGTLTKLGKRQHYVLGTFLRSFYSGFVTSDPKELMVNSTEYDRCIRSALSNLASFYAPTEEWTIEEGLAWQPIAVYYKDSASDRYLAMGSKCPKFFEIQDQRFNSTEFMNVVESHREMIEAVMYHGGVPDWQWACLLQDTVLAEKVHGLIVPEWLDPWWEELTELTEFAFFWLFNTPQQKRIRAGPILGKFIENMDNKIAGINDQIKVHMYSAHDANLVALLEALDLYERRPPFSACLLVELHELLDGEKAIRLLYLNSSTPEDINTIHPNILKLQGCGEFCPLEDFRQLTKHLIPEDWDKECQTTNELYNNEAESLSRLFGSHEFMDNKMPTTTGGTTCGPSTGSNEMIDCSVDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UHZ1</accession>
    <name>A0AAV6UHZ1_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase-like protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_029137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000392">
        <property type="protein sequence ID" value="KAG8183997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UHZ1"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106370">
        <property type="term" value="F:protein-L-histidine N-pros-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007884">
        <property type="entry name" value="METL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890">
        <property type="entry name" value="DREV PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890:SF0">
        <property type="entry name" value="PROTEIN-L-HISTIDINE N-PROS-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05219">
        <property type="entry name" value="DREV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8183997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25837" checksum="3545C35A87A7A7EE" modified="2024-11-27" version="1">MDDIFFLKENLLLLGPQWFLGRGSMFVFSSAQFENLVLPYAHLRGRWATEGNMLDLGAGDGKVTSVMARNFRHTYVTEMSGVMGRILSSQNFRLLDVDRWTLDGPDHFELISCLNLLDRCDNPLTLLRQIRVKLDPENGILILALVLPLNQYVESGSKYHRPSETIPVQGKTFEEQVSSLVRTLFEPAGFRVERWSRLPYLCEGDLDQAFYWLNDALFVLRPCTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIB7</accession>
    <name>A0AAV6UIB7_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase subunit S1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_029029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vacuolar ATPase subunit S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000397">
        <property type="protein sequence ID" value="KAG8183925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIB7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033176">
        <property type="term" value="C:proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030641">
        <property type="term" value="P:regulation of cellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008388">
        <property type="entry name" value="Ac45_acc_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046755">
        <property type="entry name" value="VAS1_LD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471:SF7">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05827">
        <property type="entry name" value="VAS1_LD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043338913" description="V-type proton ATPase subunit S1" evidence="7">
        <location>
            <begin position="26"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1 luminal" evidence="8">
        <location>
            <begin position="233"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="9">
        <location>
            <begin position="374"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8183925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="46987" checksum="EF5A8F01CD57496D" modified="2024-11-27" version="1">MGILSLSTILFTVNVFIFNFYAVSSDEVPAVLWNIKGDAMQVKPVSALGHDDTVFSDTLKEVLQNDANILLFAVNKLSLEDFSSSEMPVSSNNTLQNLQKFLDTQSYMIMSSVMDPMKHVHEAHCGVQEIVVDQSIDENILQSIAVAFQRSCVVILHITDAGVVGMTIDPKLDDIQKVFLPSFDKTSKQIVGVFTGMKSSWGNSNKEHHTLRNLLQAEEEAAVDDNKFFKIKDCLIAYAESASIFASNKTVNLTITKDTASDSDCSNSTAKLVLSFKPSEEFSSVVVTFDFNITTGSWWAKAKVVTTGGKPKDFDEELANADMSAPLGFSFSCGKFELRSKNSTNFVKFTIERFQVQPFAVKGSRFSESFDCVTWFTIPIWMGIFVSLLFILITNCGIFALYSVKTMDRFDDPKGKTITVAAAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UIM7</accession>
    <name>A0AAV6UIM7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_013212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000382">
        <property type="protein sequence ID" value="KAG8184237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UIM7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="70" mass="8121" checksum="E2FBBF5E651929D6" modified="2024-11-27" version="1">MPRKGFVGPHLFPLHSCLLTEHCTSFDRVLTEDLDYITDEMDLLFQRNKLCGTICHQKKAARKNLIVQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UJJ2</accession>
    <name>A0AAV6UJJ2_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000372">
        <property type="protein sequence ID" value="KAG8184459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UJJ2"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8184459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="215" mass="24206" checksum="6EB5C221E05DE4CD" modified="2024-11-27" version="1">MDTFPAYLGDIWCQNNLPVAKPDDLGLYQPVFETNPPTADGQSFEDDLLSLTSEFLSSDNNLWDLINSCNADQDLFSDSNFTQKNPEPEEEQNILNKEKWNIERFSSLLSFFGIGRNQRSGTYLTLSDIDNTISPEFELSDGIGNLLNLESDINSVPTECSDIEGIEVKELPVSTRSILELLQSSLQKFDLKHLYLDRVVNPIVNVAGLPLFKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UK08</accession>
    <name>A0AAV6UK08_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enhancer of mRNA-decapping protein 4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JTE90_025167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000413">
        <property type="protein sequence ID" value="KAG8183616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UK08"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.100">
        <property type="entry name" value="conserved c-terminal region of ge- 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049404">
        <property type="entry name" value="EDC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044938">
        <property type="entry name" value="EDC4_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21289">
        <property type="entry name" value="EDC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Enhancer of mRNA-decapping protein 4 C-terminal" evidence="5">
        <location>
            <begin position="239"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG8183616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="369" mass="41626" checksum="F845A132EAC29192" modified="2024-11-27" version="1">MSEDGSRHSDRELVLLSDQISATFSNKLENTLKQELTSNVVPQINRVLDTIAQKMQLDFSQKLSSTDASLRDSITKYLKGKAFMDSLSQSLSGPLQGNVHTICKDVFQSSVVPSFEKACHNLFMQLNDQFTKGTLEYVQYLEKHASKSCSSIDNLLAQVREEIPKLVTEAQQKTQAQMTATMHNVTADMMKQQREVLLQDVRHVVQEELHKQALQQSRASTPVPHVQGQMDKEHLKQQIKQLVRQDNVEEAFRMALSAMNVQLVLFLCESVSVDRVFGPTPCPLEQHVLLSLLNQLPTDLAHKTDIKVSYIDEVIPSLDVDNPITKVHLKGVLLNLQESITNFLEPNPTHRLARKLKRISLAVDALLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UKZ7</accession>
    <name>A0AAV6UKZ7_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JTE90_001499</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">W744_W776</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000360">
        <property type="protein sequence ID" value="KAG8184802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UKZ7"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="136"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="592"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG8184802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="798" mass="90934" checksum="68B677B7D4B8CF1A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UL62</accession>
    <name>A0AAV6UL62_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JTE90_004560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000374">
        <property type="protein sequence ID" value="KAG8184388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UL62"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043731155" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="38"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="220"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG8184388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="523" mass="57457" checksum="C004E7F39905E02A" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULF4</accession>
    <name>A0AAV6ULF4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UNC93-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JTE90_020021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000352">
        <property type="protein sequence ID" value="KAG8184975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULF4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF11">
        <property type="entry name" value="UNC93-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG8184975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="77672" checksum="D3B981D43826A03D" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6ULK5</accession>
    <name>A0AAV6ULK5_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diacylglycerol kinase</fullName>
            <shortName evidence="10">DAG kinase</shortName>
            <ecNumber evidence="10">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JTE90_026363</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="10"/>
    <dbReference type="EMBL" id="JAFNEN010000373">
        <property type="protein sequence ID" value="KAG8184445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6ULK5"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20801">
        <property type="entry name" value="C1_DGKepsilon_typeIII_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000019">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000007">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF118">
        <property type="entry name" value="DIACYLGLYCEROL KINASE EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="12">
        <location>
            <begin position="66"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="12">
        <location>
            <begin position="126"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="13">
        <location>
            <begin position="213"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG8184445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="542" mass="61053" checksum="8BC191525E730F00" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UMW8</accession>
    <name>A0AAV6UMW8_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein giant-lens</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_018521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000328">
        <property type="protein sequence ID" value="KAG8185644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UMW8"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021633">
        <property type="entry name" value="Argos"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11581">
        <property type="entry name" value="Argos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043439931" description="Protein giant-lens" evidence="1">
        <location>
            <begin position="22"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8185644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28527" checksum="29416378B85ADBE2" modified="2024-11-27" version="1">MERFSWLRLLWLLAALSVVRTVMVSRFPMNFRHNHKMAFRIFYQIGDSESDLPECEEMSVCNRVDTYATPWIERQCRCPNKKVCSMSIDARDGYTVVDKNRQLKLCEPVSRLPTCRYFRDVAWTYATYPDNTTKQTMHCMCPKNSVAYIFKHETYDTPKGLSALYFLACSPQSKMRCQRKEPCRLFTVKKRPDVDEVSTNTLCQCPKNHRCPQHHSEPSVISTPAGGFTEDHIRTYSGYCTSELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UPT3</accession>
    <name>A0AAV6UPT3_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Homogentisate oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Homogentisic acid oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Homogentisicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">JTE90_023904</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">W744_W776</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>homogentisate + O2 = 4-maleylacetoacetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15449"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
            <dbReference type="ChEBI" id="CHEBI:17105"/>
            <dbReference type="EC" id="1.13.11.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="5"/>
    <dbReference type="EMBL" id="JAFNEN010000341">
        <property type="protein sequence ID" value="KAG8185296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UPT3"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000026">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="20">
        <location>
            <begin position="186"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="19">
        <location>
            <begin position="461"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG8185296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="626" mass="71327" checksum="14EBE805B1F1AFD4" modified="2024-11-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UQ94</accession>
    <name>A0AAV6UQ94_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lysosomal enzyme trafficking factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transmembrane protein 251</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JTE90_004405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LYSET family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000322">
        <property type="protein sequence ID" value="KAG8185863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UQ94"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028024">
        <property type="entry name" value="LYSET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31925:SF1">
        <property type="entry name" value="LYSOSOMAL ENZYME TRAFFICKING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31925">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15190">
        <property type="entry name" value="TMEM251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG8185863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="156" mass="18300" checksum="DADB08F3B2E68D95" modified="2024-11-27" version="1">MAATCAIILCKQTKVYGEVSYYNKQSEISLWPFLTMKFRQRLAWLLLFLYLFLSLVIVYYCFELSDQYNTMALEHSKLHHSATTQKDSTWGPWSHLPDVPFFLWIFLFAIPYLQVFFCLYVCTKPEPKEILSFVPFLMCSKKVGLKDGKMACVQDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UR80</accession>
    <name>A0AAV6UR80_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_002017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000324">
        <property type="protein sequence ID" value="KAG8185791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UR80"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8185791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8878" checksum="FB80A94BB807C264" modified="2024-11-27" version="1">METTDWNRSWLQESSLVCSITTTDGALATKKAWGSNTVFSYFDLIMDCAVETPARITLRGKTDFRSVVVHCSDDAGEPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6URX4</accession>
    <name>A0AAV6URX4_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein Njmu-R1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JTE90_024117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000287">
        <property type="protein sequence ID" value="KAG8186874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6URX4"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099041">
        <property type="term" value="P:vesicle tethering to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028280">
        <property type="entry name" value="Njmu-R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14416">
        <property type="entry name" value="PROTEIN NJMU-R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14416:SF2">
        <property type="entry name" value="PROTEIN NJMU-R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15053">
        <property type="entry name" value="Njmu-R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG8186874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="44562" checksum="A2EE9D1F9A859178" modified="2024-11-27" version="1">MSASASGSSESPEPKVKIEKSSSDIKNINSRYALYLFSNNKHAASPETMGSEKNNKNDPKSDEEPSVCLSLLEGNLNAEQETVVRCFLLKTLSAREDLSFENEGKYAALQFSSENPELFGCYYHRLSKTTEDEENSKLSTFFICLIGPANGIMESFCPELGKFCYSLIPLLDPEGLKDKDCMQNKLKSWNVHCIEYIERCIKLFGEDLSLVFLCALWGNVNVIAKDEQIKWDVEQFVDTCCLMPKDLQSKKDSVLISETDVAPTITVEDNKISINISSDYSMYCKKWFEKLKNCGQGDFLGMHNVLEAFRLKTVQDLNVLKRLVQKSQMDHYALYRAFLFLRASGYDDILLYHVQKEASMAGENDVLDVISCLRDFLKEEENLPERRLAEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UTU6</accession>
    <name>A0AAV6UTU6_9ARAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JTE90_005744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000282">
        <property type="protein sequence ID" value="KAG8186971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UTU6"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG8186971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="89" mass="10147" checksum="0DA70B1654C98D02" modified="2024-11-27" version="1">MVPHVPLNGNHPTQGTWVQLKPNQTINLALQLFICVRNRTKSFRNRMSCEGVFTGVDLPKIIPRNDDIRTFEFERNKGQGETPSSAPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UU04</accession>
    <name>A0AAV6UU04_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CLIP domain-containing serine protease</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JTE90_019166</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">W744_W776</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="JAFNEN010000275">
        <property type="protein sequence ID" value="KAG8187277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UU04"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043099098" description="CLIP domain-containing serine protease" evidence="8">
        <location>
            <begin position="22"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="11">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="172"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG8187277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000827092"/>
        </source>
    </evidence>
    <sequence length="420" mass="47057" checksum="B205D00FBAA2F660" modified="2024-11-27" version="1">MRLTKVLQILFFLACAEISLGRRRRQIVFEDDDRPSRNPNSDCSTPAREPGQCVRWTRCPILRGINNWNRLQPHVCGFAGSEPRVCCPLEDEFDERNVFTTTTRRPRRTTTRKRTTTTTTRRTSPVTRGTTSTTTTTRRPTTPSTRRPTTDETKPRFLPESCGVTVFTKTRVVGGQEAERGGWPWMAVVFVEKRNGNWSPDCGGALVTTRHVITAAHCVVSGRGSATMNPRQLRVRLGAHDLRLNSEPDAIEVGVDAVRRHEQFDPRTYKNDITVLRLSRPVRFTDKIQPVCLPYDSLRTDDLTSKTSTVTGFGTTSFNGAASDVLMEVSFDITDQEECRRAYERELNITDVYLCAGTADGSKDSCQGDSGGPLVTIGKESHYYLVGVVSFGKLCAQPGYPGVYTRVTKYLDWLRTNLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-11-27" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAV6UZ48</accession>
    <name>A0AAV6UZ48_9ARAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PHD finger protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JTE90_014531</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Oedothorax gibbosus</name>
        <dbReference type="NCBI Taxonomy" id="931172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Araneae</taxon>
            <taxon>Araneomorphae</taxon>
            <taxon>Entelegynae</taxon>
            <taxon>Araneoidea</taxon>
            <taxon>Linyphiidae</taxon>
            <taxon>Erigoninae</taxon>
            <taxon>Oedothorax</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2022" name="Nat. Ecol. Evol." volume="6" first="195" last="206">
            <title>A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.</title>
            <authorList>
                <person name="Hendrickx F."/>
                <person name="De Corte Z."/>
                <person name="Sonet G."/>
                <person name="Van Belleghem S.M."/>
                <person name="Kostlbacher S."/>
                <person name="Vangestel C."/>
            </authorList>
            <dbReference type="PubMed" id="34949821"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">W744_W776</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFNEN010000223">
        <property type="protein sequence ID" value="KAG8189017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAV6UZ48"/>
    <dbReference type="Proteomes" id="UP000827092">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15533">
        <property type="entry name" value="PHD1_PHF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042163">
        <property type="entry name" value="PHF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309:SF1">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="1012"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" descriptio